locus-tag class description ASU32_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ASU32_00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ASU32_00025 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ASU32_00035 ENOG4105C57 major facilitator superfamily ASU32_00045 ENOG4105K7N UPF0232 protein ASU32_00055 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASU32_00060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASU32_00085 ENOG4105C37 (CBS) domain ASU32_00135 ENOG4105D9P serine threonine protein kinase ASU32_00140 ENOG4107TPY serine threonine protein kinase ASU32_00145 ENOG4105CJN penicillin-binding protein ASU32_00160 ENOG4105HZM Fha domain containing protein ASU32_00165 ENOG4105TV9 FHA Domain-Containing protein ASU32_00185 ENOG4105VEQ Cold shock protein ASU32_00375 ENOG4108C33 Resolvase ASU32_00415 ENOG4105ENX hydrolase ASU32_00510 ENOG4107QRI Phosphoketolase ASU32_00540 ENOG41082YX Transcriptional regulator, arsr family ASU32_00545 ENOG4105VUN Transcriptional regulator ASU32_00565 ENOG410620I Diguanylate cyclase ASU32_00595 ENOG4105VEQ Cold shock protein ASU32_00675 ENOG4105EA8 2-Nitropropane dioxygenase ASU32_00680 ENOG4105BZU Histidine kinase ASU32_00715 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ASU32_00725 ENOG4107T8Q Glycosyl transferase (Group 1 ASU32_00760 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase ASU32_00770 ENOG4105D3Q Sugar transferase ASU32_00785 ENOG4105C5W Aldolase ASU32_00815 ENOG4105D5Q Arginine ornithine antiporter ASU32_00830 ENOG4105C26 Dehydrogenase ASU32_00850 ENOG4105DWY Agmatine deiminase ASU32_00860 ENOG4105EUZ Beta-lactamase domain protein ASU32_00890 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_00915 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr ASU32_00920 ENOG4108IG5 Transcriptional regulator ASU32_00925 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 ASU32_00960 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein ASU32_00990 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase ASU32_01020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASU32_01025 ENOG4105EB3 Histidine kinase ASU32_01030 ENOG4107B2H carbonic anhydrase ASU32_01040 ENOG4105CHH sulfate transporter ASU32_01050 ENOG4108KXV response regulator ASU32_01055 ENOG41065SU Two-component system sensor kinase ASU32_01070 ENOG4105DIM ABC transporter ASU32_01075 ENOG4105CIG ABC transporter ASU32_01085 ENOG4107S5I aldo keto reductase ASU32_01090 ENOG4105C4B ABC transporter, permease ASU32_01095 ENOG4105CBC glutamate synthase ASU32_01115 ENOG410848D S4 domain protein YaaA ASU32_01125 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASU32_01130 ENOG4105C26 Dehydrogenase ASU32_01145 ENOG4108VQR secreted hydrolase ASU32_01160 ENOG4105K64 Glycosyl transferase, family 2 ASU32_01170 ENOG4105EC2 ftsk spoIIIe ASU32_01255 ENOG4108HUF Transporter ASU32_01345 ENOG4108KGH TRANSCRIPTIONal ASU32_01355 ENOG4105C7N Xanthine uracil vitamin C permease ASU32_01365 ENOG4108RFG Tetr family transcriptional regulator ASU32_01370 ENOG4105C57 major facilitator superfamily ASU32_01400 ENOG4105CQC Prephenate dehydratase ASU32_01410 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASU32_01425 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ASU32_01445 ENOG4107B57 rieske 2fe-2S domain-containing protein ASU32_01455 ENOG410667J hydrolase ASU32_01465 ENOG4105JFG SpoIID LytB domain protein ASU32_01475 ENOG410602S Transferase ASU32_01485 ENOG4106YN8 Prenyltransferase ASU32_01490 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids ASU32_01500 ENOG4105BZU Histidine kinase ASU32_01530 ENOG4105DWY Agmatine deiminase ASU32_01535 ENOG4108M8W Monooxygenase ASU32_01550 ENOG4105D8K carboxyl transferase ASU32_01555 ENOG4105CQB FAD linked oxidase domain protein ASU32_01565 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) ASU32_01580 ENOG4108ZGC gaf domain protein ASU32_01610 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ASU32_01615 ENOG4105E98 transcriptional regulator DeoR family ASU32_01620 ENOG4105DE4 1-phosphofructokinase ASU32_01625 ENOG4105DM4 PTS System ASU32_01640 ENOG4105F9U Dehydrogenase ASU32_01650 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASU32_01655 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASU32_01690 ENOG4105KXX peptidase s58 dmpa ASU32_01700 ENOG4105K56 Transcriptional regulator ASU32_01740 ENOG4105DZ2 Transcriptional regulator ASU32_01760 ENOG4105WBV Transcriptional regulator ASU32_01765 ENOG4108QER Adenylate cyclase ASU32_01770 ENOG4105EJQ L-serine dehydratase ASU32_01785 ENOG4105T0Z Conserved Protein ASU32_01790 ENOG4105MZU cell filamentation protein ASU32_01820 ENOG4106F1P AAA ATPase, central domain protein ASU32_01830 ENOG4105EC2 ftsk spoIIIe ASU32_01910 ENOG4105CHU acetyl-coa acetyltransferase ASU32_01930 ENOG4105C9K Endothelin-converting enzyme 1 ASU32_01985 ENOG4108IJ0 Aspartate ammonia-lyase ASU32_02005 ENOG4105EJ2 Transcriptional regulator ASU32_02060 ENOG4107R13 MMPL domain protein ASU32_02070 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ASU32_02075 ENOG41064B9 (LipO)protein ASU32_02105 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) ASU32_02120 ENOG410900P UPF0336 protein ASU32_02140 ENOG4105CRK lysyL-tRNA synthetase ASU32_02150 ENOG4105CN2 monooxygenase, FAD-binding ASU32_02170 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASU32_02185 ENOG4108KPJ rna polymerase sigma factor ASU32_02195 ENOG4108M6P methyltransferase ASU32_02215 ENOG4105C3M thioredoxin reductase ASU32_02275 ENOG41073B4 coagulation factor 5 8 type domain-containing protein ASU32_02295 ENOG4105D17 glycoside hydrolase, family 3 domain protein ASU32_02300 ENOG4108W9H Tetr family transcriptional regulator ASU32_02315 ENOG4105CHR reductase ASU32_02320 ENOG4105CHU acetyl-coa acetyltransferase ASU32_02325 ENOG4105K4P CoA-binding domain protein ASU32_02350 ENOG4105CSU acyl-Coa dehydrogenase ASU32_02370 ENOG4105C57 major facilitator superfamily ASU32_02400 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_02410 ENOG4105CSV Glutaminase ASU32_02415 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASU32_02425 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) ASU32_02455 ENOG4105DHP deoxycytidine triphosphate deaminase ASU32_02485 ENOG4105DF6 Fe-S oxidoreductase ASU32_02505 ENOG4108X07 Tetr family transcriptional regulator ASU32_02510 ENOG4105F95 Monooxygenase ASU32_02535 ENOG4105CGK Exodeoxyribonuclease III ASU32_02545 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 ASU32_02585 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ASU32_02595 ENOG4105CFG Acts as a chaperone (By similarity) ASU32_02600 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ASU32_02605 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASU32_02610 ENOG4105KNI merR family transcriptional Regulator ASU32_02645 ENOG4105D74 hydrolase ASU32_02665 ENOG4105VG5 Membrane ASU32_02725 ENOG4105C5H ABC transporter ASU32_02730 ENOG4105DQR SNARE associated Golgi ASU32_02735 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN ASU32_02775 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ASU32_02790 ENOG4107QNK )-transporter ASU32_02795 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ASU32_02850 ENOG4106N3A copper homeostasis protein cutc ASU32_02855 ENOG4105E0Y RtcB Protein ASU32_02885 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASU32_02910 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ASU32_02915 ENOG4108UGV hypoxanthine phosphoribosyltransferase ASU32_02935 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ASU32_02940 ENOG4105EUJ GTP cyclohydrolase i ASU32_02945 ENOG4105EEI dihydropteroate synthase ASU32_02975 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ASU32_02980 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) ASU32_02985 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) ASU32_02995 ENOG4105DK7 lysyl-tRNA synthetase ASU32_03005 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASU32_03020 ENOG4105MXW flavin reductase domain protein, FMN-binding ASU32_03045 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) ASU32_03050 ENOG4105PDP Short chain dehydrogenase ASU32_03060 ENOG4107ZXU DSBA oxidoreductase ASU32_03065 ENOG4105CHR reductase ASU32_03075 ENOG4105CEN a g-specific adenine glycosylase ASU32_03080 ENOG4108V9Q carbonic anhydrase ASU32_03090 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) ASU32_03095 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ASU32_03110 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ASU32_03115 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ASU32_03125 ENOG4105C8N cysteinyl-tRNA synthetase ASU32_03130 ENOG4105C2N RNA methyltransferase TrmH family group 3 ASU32_03140 ENOG4105E7W lamb ycsf family protein ASU32_03145 ENOG4105CC5 ABC transporter ASU32_03150 ENOG4105FDK ABC transporter ASU32_03185 ENOG4105EUB pirin domain protein ASU32_03190 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ASU32_03195 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ASU32_03205 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASU32_03215 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ASU32_03230 ENOG4105CBP Major Facilitator ASU32_03240 ENOG41082BM Transcriptional regulator, arsr family ASU32_03255 ENOG4105CPC Aldo Keto reductase ASU32_03280 ENOG4105DKW ABC transporter ASU32_03285 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) ASU32_03290 ENOG4107RSM transcriptional regulator ASU32_03295 ENOG4105D94 Major Facilitator Superfamily ASU32_03300 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ASU32_03310 ENOG4105BZ9 Cytochrome C oxidase, subunit I ASU32_03325 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ASU32_03335 ENOG4105BZU Histidine kinase ASU32_03340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASU32_03380 ENOG4105II7 pyrroline-5-carboxylate reductase ASU32_03405 ENOG4108RXW HAD-superfamily subfamily IB hydrolase ASU32_03415 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ASU32_03420 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ASU32_03425 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ASU32_03475 ENOG41080ZE Adenylate cyclase ASU32_03480 ENOG4107R13 MMPL domain protein ASU32_03490 ENOG4105ETS cytosine purines uracil thiamine allantoin ASU32_03495 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ASU32_03500 ENOG4108UMI ABC transporter, permease ASU32_03520 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASU32_03525 ENOG4105DGI Alkaline phosphatase ASU32_03530 ENOG4105EBR Carboxylesterase ASU32_03540 ENOG41086VY Fic/DOC family ASU32_03550 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ASU32_03555 ENOG4108RH7 phosphoglycerate mutase ASU32_03560 ENOG4107QX9 Thiol disulfide interChange protein ASU32_03565 ENOG4107QIV Cytochrome c biogenesis protein ASU32_03575 ENOG4105CRE cytochrome C ASU32_03610 ENOG4105CSU acyl-Coa dehydrogenase ASU32_03685 ENOG4107TCW O-succinylbenzoate synthase ASU32_03705 ENOG4105DV0 amidase (EC 3.5.1.4 ASU32_03720 ENOG4105XTG Pfam:DUF156 ASU32_03725 ENOG4105EG6 Saccharopine dehydrogenase ASU32_03730 ENOG4108KK1 membrane protein AbrB duplication ASU32_03740 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ASU32_03755 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ASU32_03775 ENOG4108VPT UPF0234 protein ASU32_03800 ENOG410900P UPF0336 protein ASU32_03805 ENOG4108F01 MaoC domain protein ASU32_03815 ENOG410683Z Preprotein translocase SecE subunit ASU32_03825 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ASU32_03830 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ASU32_03865 ENOG4108VZM 50s ribosomal protein L10 ASU32_03880 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASU32_03885 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASU32_03950 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein ASU32_03970 ENOG4105DIA mandelate racemase muconate lactonizing ASU32_03985 ENOG4105JXH GntR family transcriptional regulator ASU32_04015 ENOG4105C0D helicase ASU32_04050 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_04060 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ASU32_04070 ENOG4105ENX hydrolase ASU32_04085 ENOG4105XDV ASU32_04105 ENOG4106BQ7 Glycosyl Transferase ASU32_04115 ENOG4105CMT Dihydroxyacetone kinase ASU32_04150 ENOG4105E39 Enoyl-CoA hydratase ASU32_04160 ENOG4105NPE arsR family transcriptional regulator ASU32_04165 ENOG4105DRP amino acid AbC transporter ASU32_04170 ENOG4105CDA abc transporter atp-binding protein ASU32_04180 ENOG4105JAB phenazine biosynthesis protein, phzf family ASU32_04185 ENOG4105CE4 GlcNAc 6-P deacetylase ASU32_04220 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ASU32_04245 ENOG4105FDP GntR family transcriptional regulator ASU32_04255 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) ASU32_04285 ENOG4107R7A Allophanate hydrolase subunit 2 ASU32_04295 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ASU32_04300 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit ASU32_04305 ENOG4105E7W lamb ycsf family protein ASU32_04350 ENOG4105CFI type iii restriction protein res subunit ASU32_04375 ENOG4105CHP RNA polymerase ASU32_04420 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASU32_04430 ENOG4105VEQ Cold shock protein ASU32_04450 ENOG4108N0W Major Facilitator superfamily ASU32_04510 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ASU32_04520 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ASU32_04530 ENOG4105EV4 Multidrug resistance protein mdtH ASU32_04540 ENOG4105EMU Dehydrogenase ASU32_04560 ENOG41081K0 peptidylprolyl cis-trans isomerase ASU32_04600 ENOG4105CV8 reductase ASU32_04635 ENOG4107RN3 metallophosphoesterase ASU32_04645 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASU32_04680 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo ASU32_04690 ENOG4105EKT )-iron permease ASU32_04695 ENOG4105DBE peroxidase ASU32_04710 ENOG4108VW9 Membrane ASU32_04725 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ASU32_04730 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase ASU32_04740 ENOG4107QP8 phosphohexose isomerase ASU32_04750 ENOG41061MV Arylsulfatase ASU32_04765 ENOG4105E6M Sulphatase-modifying factor protein ASU32_04820 ENOG4105DR5 peptidase ASU32_04845 ENOG4107QX3 carboxylase ASU32_04855 ENOG4105C1G acyl-Coa dehydrogenase ASU32_04870 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_04875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASU32_04895 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) ASU32_04910 ENOG4105CMV Succinyl-CoA synthetase subunit beta ASU32_04920 ENOG4105EQ0 Major Facilitator superfamily ASU32_04945 ENOG4105DC1 bifunctional purine biosynthesis protein purh ASU32_04955 ENOG4105MHT Transcriptional regulator, ARSR family ASU32_04970 ENOG4105EET magnesium chelatase ASU32_04975 ENOG4107KWJ von Willebrand factor, type A ASU32_04995 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ASU32_05000 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ASU32_05005 ENOG4105W0E 50S ribosomal protein L33 ASU32_05010 ENOG4105KDC 50s ribosomal protein l28 ASU32_05020 ENOG4105NRA 50s ribosomal protein l31 type b ASU32_05030 ENOG4105EN6 Membrane ASU32_05035 ENOG4105ETX regulatoR ASU32_05040 ENOG41062D9 Histidine kinase ASU32_05045 ENOG4105C0H protease ASU32_05050 ENOG4108RIR Molybdenum cofactor biosynthesis protein ASU32_05120 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase ASU32_05125 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ASU32_05135 ENOG4105D9U N-acetyltransferase ASU32_05160 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ASU32_05165 ENOG4105KVH Transcriptional regulator ASU32_05195 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) ASU32_05210 ENOG4108UMN azlc family ASU32_05215 ENOG4105EW9 transcriptional regulator AsnC family ASU32_05265 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) ASU32_05270 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ASU32_05275 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ASU32_05285 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASU32_05330 ENOG4105F8V Hydrolase, tatD family ASU32_05335 ENOG4106839 domain protein ASU32_05340 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ASU32_05345 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ASU32_05365 ENOG4105C5H ABC transporter ASU32_05385 ENOG4105N14 lysine exporter protein LysE YggA ASU32_05405 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ASU32_05415 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ASU32_05420 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ASU32_05440 ENOG4105BZU Histidine kinase ASU32_05450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASU32_05460 ENOG4105EZR dyp-type peroxidase family protein ASU32_05485 ENOG4105K89 arsenate reductase ASU32_05500 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASU32_05550 ENOG4105DXN mazG family ASU32_05570 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 ASU32_05575 ENOG4108RZE Tetr family transcriptional regulator ASU32_05585 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASU32_05600 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASU32_05605 ENOG4105DF2 NADH dehydrogenase subunit j ASU32_05610 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASU32_05615 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) ASU32_05620 ENOG4108IEH NADH dehydrogenase subunit g ASU32_05635 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASU32_05640 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ASU32_05645 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASU32_05665 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ASU32_05695 ENOG4105KPY Small multidrug resistance protein ASU32_05705 ENOG4105D8X mechanosensitive ion channel ASU32_05710 ENOG4105NAE bifunctional deaminase-reductase domain protein ASU32_05760 ENOG4107T94 Endo-14-beta-xylanase ASU32_05765 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ASU32_05780 ENOG4105T1M mycothiol conjugate amidase mca ASU32_05790 ENOG4105EDW glycosyl transferase, family 39 ASU32_05795 ENOG4105KME endoribonuclease L-psp ASU32_05810 ENOG4105C7Z Conserved Protein ASU32_05815 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASU32_05835 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ASU32_05840 ENOG4106FTQ Taurine ABC transporter, periplasmic ASU32_05845 ENOG4108IY8 ABC, transporter ASU32_05865 ENOG4105CS9 pantothenic acid kinase ASU32_05875 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASU32_05890 ENOG4108IAB Phoh family ASU32_05895 ENOG4108XET gCN5-related N-acetyltransferase ASU32_05925 ENOG4107GFK fumarate ASU32_05970 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ASU32_05980 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ASU32_05985 ENOG4107VQS DivIVA family ASU32_06000 ENOG4105C02 permease ASU32_06005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASU32_06020 ENOG4105D22 carbon starvation protein ASU32_06030 ENOG4105CNN ABC, transporter ASU32_06040 ENOG4105C3G gtp-binding protein ASU32_06110 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ASU32_06130 ENOG4105WD1 Membrane ASU32_06140 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ASU32_06240 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 ASU32_06250 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASU32_06255 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASU32_06260 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ASU32_06270 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) ASU32_06280 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) ASU32_06285 ENOG4105EM7 Selenocysteine-specific translation elongation factor ASU32_06310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASU32_06315 ENOG4105C26 Dehydrogenase ASU32_06320 ENOG4105C1G acyl-Coa dehydrogenase ASU32_06350 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ASU32_06355 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ASU32_06360 ENOG4105DKQ ROK family ASU32_06375 ENOG4106UW1 Major Facilitator superfamily ASU32_06405 ENOG4108UCS ABC, transporter ASU32_06420 ENOG4105CPC Aldo Keto reductase ASU32_06445 ENOG4107USK Extracellular solute-binding protein, family 5 ASU32_06450 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) ASU32_06460 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) ASU32_06470 ENOG4105D9N nucleoside ASU32_06475 ENOG4108Z4U Ferredoxin ASU32_06485 ENOG4105E18 UPF0276 protein ASU32_06500 ENOG4105CHU acetyl-coa acetyltransferase ASU32_06505 ENOG4108WC5 Alpha Beta Hydrolase Fold protein ASU32_06510 ENOG4107QNJ CoA-transferase subunit B ASU32_06525 ENOG4108QMY dioxygenase ASU32_06535 ENOG4106NZI LysR family Transcriptional regulator ASU32_06540 ENOG4105FUY alpha subunit ASU32_06575 ENOG4105CJW magnesium transporter ASU32_06580 ENOG4107R4C succinyl-diaminopimelate desuccinylase ASU32_06585 ENOG4108URH decarboxylase ASU32_06590 ENOG4108URH decarboxylase ASU32_06600 ENOG4105EEI dihydropteroate synthase ASU32_06605 ENOG4105C3Q Glycosyl transferase, family 2 ASU32_06610 ENOG4108Z6Z Transcriptional regulator ASU32_06635 ENOG4107QPH glycogen) synthase ASU32_06640 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASU32_06665 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase ASU32_06670 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ASU32_06695 ENOG4105EIP mannose-6-phosphate isomerase ASU32_06705 ENOG4105BZ1 (ABC) transporter ASU32_06710 ENOG4105CUB amino acid ASU32_06720 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) ASU32_06735 ENOG4105CJW magnesium transporter ASU32_06790 ENOG4105CG3 alpha amylase, catalytic region ASU32_06795 ENOG4105ETE Transcriptional regulator (LacI family ASU32_06805 ENOG4105D7N magnesium and cobalt transport protein CorA ASU32_06820 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) ASU32_06825 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ASU32_06845 ENOG4105C0D helicase ASU32_06880 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_06890 ENOG4107RDB Major Facilitator ASU32_06895 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ASU32_06905 ENOG4105BZU Histidine kinase ASU32_06935 ENOG4105C75 arginyL-tRNA synthetase ASU32_06940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ASU32_06945 ENOG4105D6E homoserine dehydrogenase ASU32_06950 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ASU32_06955 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ASU32_06970 ENOG4105VFB Binds the 23S rRNA (By similarity) ASU32_06975 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ASU32_06980 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ASU32_07050 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) ASU32_07055 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASU32_07065 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASU32_07070 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ASU32_07075 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ASU32_07080 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ASU32_07085 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ASU32_07100 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ASU32_07120 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) ASU32_07140 ENOG4105CHU acetyl-coa acetyltransferase ASU32_07170 ENOG4105DRS transport system, permease ASU32_07180 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_07190 ENOG4105DWT malate dehydrogenase (quinone) ASU32_07205 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ASU32_07210 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) ASU32_07230 ENOG4105DXI Major Facilitator superfamily ASU32_07255 ENOG4105BZW Glycerate kinase ASU32_07260 ENOG41060W2 glyoxylate carboligase ASU32_07265 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ASU32_07270 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ASU32_07275 ENOG4105C2W permease ASU32_07285 ENOG4105VT2 5-hydroxyisourate hydrolase ASU32_07315 ENOG4108RWI nicotinamidase ASU32_07320 ENOG4107RKP Nicotinate phosphoribosyltransferase ASU32_07325 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ASU32_07355 ENOG4108RQ5 Beta-lactamase domain-containing protein ASU32_07360 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ASU32_07365 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASU32_07370 ENOG4107TB5 TRANSCRIPTIONal ASU32_07420 ENOG4105F9E Shikimate 5-dehydrogenase ASU32_07430 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ASU32_07440 ENOG4105IBS Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ASU32_07445 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ASU32_07455 ENOG4105C1G acyl-Coa dehydrogenase ASU32_07470 ENOG4105DND Transcriptional regulator ASU32_07500 ENOG4105DQ4 alcohol dehydrogenase ASU32_07515 ENOG4105C1G acyl-Coa dehydrogenase ASU32_07520 ENOG410905X membrane-flanked domain protein ASU32_07545 ENOG4105CK7 Sodium proline symporter ASU32_07555 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ASU32_07560 ENOG4105CBC glutamate synthase ASU32_07575 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ASU32_07585 ENOG4105D7A ATP-binding protein ASU32_07595 ENOG4105E1F short-chain dehydrogenase reductase ASU32_07600 ENOG4105MGM doxx family ASU32_07610 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASU32_07615 ENOG4105U3E Transcriptional regulator ASU32_07640 ENOG4105D4T Citrate transporter ASU32_07645 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASU32_07650 ENOG4106YYS transcriptional regulatory protein ASU32_07670 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ASU32_07675 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit ASU32_07680 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit ASU32_07685 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit ASU32_07690 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit ASU32_07695 ENOG4105CGU Enoyl-CoA hydratase ASU32_07710 ENOG41067SE Tetr family transcriptional regulator ASU32_07715 ENOG4105DXM phenylacetic acid degradation protein ASU32_07735 ENOG4105C26 Dehydrogenase ASU32_07740 ENOG4107R3N Filamentation induced by cAMP protein fic ASU32_07750 ENOG4105CJ1 ABC, transporter ASU32_07770 ENOG4105DEN Luciferase family ASU32_07780 ENOG4105FBW Monooxygenase ASU32_07830 ENOG4107QZF nitrite reductase NADPH large subunit ASU32_07835 ENOG4107QZF nitrite reductase NADPH large subunit ASU32_07845 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASU32_07885 ENOG4105C7I Dehydrogenase ASU32_07890 ENOG4108TGP Thioesterase superfamily protein ASU32_07910 ENOG4105CG3 alpha amylase, catalytic region ASU32_07925 ENOG4105BZU Histidine kinase ASU32_07940 ENOG4109057 ASU32_07945 ENOG4105K5B UPF0225 protein ASU32_07960 ENOG4105MC2 DSBA oxidoreductase ASU32_07965 ENOG4108K0D peptidase, M48 ASU32_08000 ENOG4105CVG Homoserine O-transsuccinylase ASU32_08020 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_08030 ENOG4105JZI cytochrome P450 ASU32_08045 ENOG4105CUB amino acid ASU32_08065 ENOG4105E39 Enoyl-CoA hydratase ASU32_08085 ENOG4105C57 major facilitator superfamily ASU32_08150 ENOG4105VTR Integrase ASU32_08190 ENOG4108JCI Transcriptional regulator ASU32_08195 ENOG4105DKK Benzoate ASU32_08250 ENOG4105E0T Short-chain dehydrogenase reductase Sdr ASU32_08275 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ASU32_08285 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ASU32_08300 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ASU32_08305 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ASU32_08315 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ASU32_08320 ENOG4105C03 ribonuclease ASU32_08325 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ASU32_08330 ENOG4105K46 50S ribosomal protein l27 ASU32_08335 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ASU32_08340 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ASU32_08350 ENOG4105URP P-aminobenzoate N-oxygenase AurF ASU32_08355 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ASU32_08360 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ASU32_08380 ENOG4105D7N magnesium and cobalt transport protein CorA ASU32_08390 ENOG4105CSH Transporter ASU32_08415 ENOG4105CR4 methylisocitrate lyase ASU32_08430 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) ASU32_08440 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase ASU32_08445 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid ASU32_08450 ENOG4108RVA ribokinase ASU32_08470 ENOG4105CSH Transporter ASU32_08475 ENOG4106H78 methyltransferase ASU32_08480 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ASU32_08485 ENOG41087HT growth ASU32_08495 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ASU32_08500 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ASU32_08530 ENOG4108375 Acylphosphatase (EC 3.6.1.7) ASU32_08540 ENOG4106032 Glutathionylspermidine synthase ASU32_08545 ENOG4105P3N Membrane ASU32_08550 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ASU32_08555 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ASU32_08600 ENOG4105JN3 extra-cytoplasmic solute receptor family protein ASU32_08630 ENOG4108YZ9 Urea amidohydrolase subunit gamma ASU32_08635 ENOG4105KI2 Urea amidohydrolase subunit beta ASU32_08640 ENOG4105CQM Urea amidohydrolase subunit alpha ASU32_08645 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) ASU32_08650 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) ASU32_08655 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) ASU32_08660 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) ASU32_08665 ENOG4105D9G High-affinity ASU32_08675 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ASU32_08685 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ASU32_08730 ENOG4105E8V Alpha Beta Hydrolase Fold protein ASU32_08735 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ASU32_08745 ENOG4108IG5 Transcriptional regulator ASU32_08770 ENOG4105GRZ Ycii-related protein ASU32_08775 ENOG4105CHP RNA polymerase ASU32_08795 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ASU32_08820 ENOG4105K5M 30s ribosomal protein S16 ASU32_08830 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ASU32_08835 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ASU32_08880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ASU32_08895 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASU32_08915 ENOG41080R2 UPF0102 protein ASU32_08920 ENOG4105C0P Mg chelatase subunit ChlI ASU32_08940 ENOG4105D01 (LipO)protein ASU32_08945 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ASU32_08950 ENOG4108UMI ABC transporter, permease ASU32_08955 ENOG4105CSH Transporter ASU32_08960 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASU32_08965 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ASU32_08985 ENOG4105D0M Protease HtpX homolog ASU32_08990 ENOG4105C2C drug resistance transporter, Bcr CflA ASU32_09000 ENOG4105CFG Acts as a chaperone (By similarity) ASU32_09010 ENOG4108ETY sodium dicarboxylate symporter ASU32_09020 ENOG4105EBR Carboxylesterase ASU32_09030 ENOG4105BZG amino acid carrier protein ASU32_09035 ENOG4105CE9 30S ribosomal protein S2 ASU32_09040 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ASU32_09060 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ASU32_09065 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ASU32_09070 ENOG4105KNE Phosphatidate cytidylyltransferase ASU32_09085 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ASU32_09110 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ASU32_09115 ENOG4105DZP Membrane-associated zinc metalloprotease ASU32_09120 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ASU32_09135 ENOG4105DWY Agmatine deiminase ASU32_09160 ENOG4105CHU acetyl-coa acetyltransferase ASU32_09165 ENOG4105CJN penicillin-binding protein ASU32_09180 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ASU32_09185 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ASU32_09200 ENOG4105DWT malate dehydrogenase (quinone) ASU32_09230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ASU32_09245 ENOG4107XFJ UPF0246 protein ASU32_09250 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ASU32_09270 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) ASU32_09295 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ASU32_09300 ENOG4105SFS phosphoesterase RecJ domain protein ASU32_09305 ENOG4107QI1 Mate efflux family protein ASU32_09315 ENOG4107SCA Formamidase (EC 3.5.1.49) ASU32_09340 ENOG4108MES Periplasmic binding protein ASU32_09355 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ASU32_09385 ENOG4105CHR reductase ASU32_09390 ENOG4108IND Tetr family transcriptional regulator ASU32_09395 ENOG4107R5H iron (metal) dependent repressor, dtxr family ASU32_09405 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ASU32_09410 ENOG4105CHR reductase ASU32_09425 ENOG4105CRK lysyL-tRNA synthetase ASU32_09430 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ASU32_09435 ENOG4105C1V Peptidase, M16 ASU32_09445 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) ASU32_09450 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ASU32_09470 ENOG4105DCF alanine dehydrogenase ASU32_09475 ENOG4105F7P transcriptional regulator AsnC family ASU32_09495 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) ASU32_09505 ENOG4107R13 MMPL domain protein ASU32_09540 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ASU32_09550 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ASU32_09555 ENOG4105CN5 Metallo-Beta-Lactamase ASU32_09615 ENOG4105CEV competence damage-inducible protein ASU32_09620 ENOG4105WBV Transcriptional regulator ASU32_09645 ENOG4105J1Z Arabinosyltransferase ASU32_09660 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ASU32_09665 ENOG4105KC9 Modulates RecA activity (By similarity) ASU32_09675 ENOG4107UBR Extracellular solute-binding protein family 3 ASU32_09680 ENOG4105DRP amino acid AbC transporter ASU32_09685 ENOG4108Q1T ABC transporter ASU32_09690 ENOG4107UBR Extracellular solute-binding protein family 3 ASU32_09695 ENOG4105CDA abc transporter atp-binding protein ASU32_09700 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ASU32_09710 ENOG4105C99 atpase involved in dna repair ASU32_09720 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ASU32_09725 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ASU32_09730 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ASU32_09745 ENOG4105CC9 acyl-Coa dehydrogenase ASU32_09750 ENOG4105C1G acyl-Coa dehydrogenase ASU32_09755 ENOG4105C5Q Transcriptional regulator ASU32_09765 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ASU32_09775 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ASU32_09780 ENOG4105CQ7 ATP-dependent helicase ASU32_09785 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASU32_09795 ENOG4107QN1 sodium solute ASU32_09800 ENOG4108KPJ rna polymerase sigma factor ASU32_09825 ENOG4105C5Q Transcriptional regulator ASU32_09830 ENOG4105D3W isochorismatase ASU32_09875 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ASU32_09900 ENOG4105DGU Histone deacetylase ASU32_09915 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ASU32_09950 ENOG4105C9K Endothelin-converting enzyme 1 ASU32_09970 ENOG4105CHU acetyl-coa acetyltransferase ASU32_09975 ENOG4105CHR reductase ASU32_09985 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ASU32_09990 ENOG4105PAD Hydrolase ASU32_10015 ENOG4105D2B acyl-CoA dehydrogenase ASU32_10020 ENOG4105D2B acyl-CoA dehydrogenase ASU32_10030 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_10035 ENOG4105E5G Alpha beta hydrolase fold ASU32_10050 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_10055 ENOG4108JIK carboxylase ASU32_10075 ENOG4105IIP Membrane ASU32_10115 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ASU32_10135 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ASU32_10140 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ASU32_10155 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ASU32_10165 ENOG4107JTW chlorite dismutase ASU32_10170 ENOG4105E0X reductase ASU32_10185 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ASU32_10195 ENOG4105VPX protein, conserved in bacteria ASU32_10215 ENOG4107QX3 carboxylase ASU32_10225 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ASU32_10280 ENOG4108XIC integral membrane protein ASU32_10300 ENOG4108YUY ASU32_10305 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 ASU32_10310 ENOG4105CHR reductase ASU32_10330 ENOG4105F27 Major Facilitator ASU32_10360 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ASU32_10390 ENOG4105C22 threonyL-tRNA synthetase ASU32_10400 ENOG4108VTU Cdp-alcohol phosphatidyltransferase ASU32_10405 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase ASU32_10410 ENOG4105E2K Glycosyl transferase (Group 1 ASU32_10415 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ASU32_10435 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) ASU32_10450 ENOG4105C29 acyl-CoA thioesterase ASU32_10455 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) ASU32_10465 ENOG4105CDY transcriptional regulatory protein ASU32_10475 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ASU32_10480 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ASU32_10485 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ASU32_10490 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase ASU32_10495 ENOG4105EDW glycosyl transferase, family 39 ASU32_10510 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ASU32_10525 ENOG4105D2S major facilitator superfamily ASU32_10540 ENOG4105C9U ATP-dependent DNA helicase RecQ ASU32_10555 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASU32_10560 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ASU32_10565 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASU32_10580 ENOG4105CUT histidyl-tRNA synthetase ASU32_10595 ENOG41082BM Transcriptional regulator, arsr family ASU32_10605 ENOG4105CKI cobalamin synthesis protein ASU32_10630 ENOG4105CSH Transporter ASU32_10635 ENOG4105CPU Monooxygenase ASU32_10645 ENOG4107XZQ multidrug resistance protein ASU32_10670 ENOG4105C9M aspartyl-trna synthetase ASU32_10700 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ASU32_10705 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ASU32_10710 ENOG4105HHA aminodeoxychorismate lyase ASU32_10730 ENOG4105CPU Monooxygenase ASU32_10735 ENOG4105DEN Luciferase family ASU32_10740 ENOG4105CPU Monooxygenase ASU32_10745 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_10755 ENOG4105EAB amino acid AbC transporter ASU32_10760 ENOG4105CDA abc transporter atp-binding protein ASU32_10765 ENOG4105E5Q amino acid AbC transporter ASU32_10770 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_10775 ENOG4105BZU Histidine kinase ASU32_10815 ENOG4105DEN Luciferase family ASU32_10820 ENOG4105DYW oxidoreductase ASU32_10840 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASU32_10850 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ASU32_10855 ENOG4105SBG acid phosphatase ASU32_10860 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ASU32_10875 ENOG4108UZX fmn reductase ASU32_10900 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ASU32_10925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASU32_10960 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ASU32_10965 ENOG4105CIH Imidazole acetol-phosphate transaminase ASU32_10970 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ASU32_10985 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease ASU32_10990 ENOG410633P Hydantoin racemase ASU32_10995 ENOG4105CK2 sodium dicarboxylate symporter ASU32_11000 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) ASU32_11005 ENOG4105S0E allantoin catabolism protein ASU32_11015 ENOG4107QUY Guanine deaminase ASU32_11025 ENOG4105C7W Xanthine dehydrogenase ASU32_11035 ENOG4105C7N Xanthine uracil vitamin C permease ASU32_11040 ENOG41069M3 Transcriptional regulator ASU32_11065 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ASU32_11075 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ASU32_11080 ENOG4108MWI inositol mono-phosphatase ASU32_11085 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ASU32_11090 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ASU32_11105 ENOG4105CRQ synthase (Component I) ASU32_11115 ENOG4105DK0 Indole-3-glycerol phosphate synthase ASU32_11120 ENOG4105RD7 BadF BadG BcrA BcrD ASU32_11125 ENOG4107QNK )-transporter ASU32_11130 ENOG4105FDP GntR family transcriptional regulator ASU32_11140 ENOG4105CDA abc transporter atp-binding protein ASU32_11145 ENOG4105DRP amino acid AbC transporter ASU32_11160 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ASU32_11165 ENOG4105BZU Histidine kinase ASU32_11175 ENOG4105BZU Histidine kinase ASU32_11180 ENOG4105C5H ABC transporter ASU32_11185 ENOG4105EWI Short-chain dehydrogenase reductase Sdr ASU32_11210 ENOG4107Z3H Transcriptional regulator, TetR family ASU32_11215 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) ASU32_11220 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_11250 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ASU32_11270 ENOG4108Q5F Tetr family transcriptional regulator ASU32_11275 ENOG4107QM5 aconitate hydratase ASU32_11285 ENOG4105ZXU NLP P60 protein ASU32_11290 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ASU32_11310 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ASU32_11315 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ASU32_11405 ENOG4105CY5 solute-binding protein ASU32_11415 ENOG4105FDP GntR family transcriptional regulator ASU32_11450 ENOG4105DV0 amidase (EC 3.5.1.4 ASU32_11460 ENOG4105C7K acetolactate synthase ASU32_11470 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASU32_11480 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ASU32_11500 ENOG4105CUB amino acid ASU32_11515 ENOG4105NGS secreted protein ASU32_11525 ENOG4107PBH Toxic component of a toxin-antitoxin (TA) module. A ASU32_11560 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ASU32_11565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASU32_11580 ENOG4108NJC ASU32_11595 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ASU32_11605 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ASU32_11620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ASU32_11625 ENOG4105DND Transcriptional regulator ASU32_11630 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ASU32_11665 ENOG4105E18 UPF0276 protein ASU32_11680 ENOG4105C8N cysteinyl-tRNA synthetase ASU32_11695 ENOG4105C3R Methionine synthase ASU32_11715 ENOG4107T31 5'-nucleotidase ASU32_11720 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASU32_11740 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ASU32_11755 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) ASU32_11760 ENOG4105IDI abc transporter atp-binding protein ASU32_11765 ENOG4105E5F proteasome ASU32_11780 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) ASU32_11785 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) ASU32_11790 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) ASU32_11800 ENOG4105DTD Dehydrogenase ASU32_11805 ENOG41064MX Tetr family transcriptional regulator ASU32_11810 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) ASU32_11820 ENOG4107TMB Transcriptional regulator ASU32_11865 ENOG4108RG3 short-chain dehydrogenase reductase ASU32_11895 ENOG410905P Pyridoxamine 5-phosphate ASU32_11900 ENOG4105F27 Major Facilitator ASU32_11925 ENOG41081F0 Precorrin-8x methylmutase ASU32_11950 ENOG41080R8 Conserved Protein ASU32_11960 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ASU32_11965 ENOG41073TP transcriptional regulator ASU32_11970 ENOG4105CTK cobaltochelatase, cobn subunit ASU32_11980 ENOG4105CD3 dihydroorotase ASU32_11990 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) ASU32_11995 ENOG4105Q70 ASU32_12020 ENOG4105CT3 Monooxygenase ASU32_12035 ENOG4108Z0R Transferase ASU32_12045 ENOG4105C0A alcohol dehydrogenase ASU32_12065 ENOG4105JXH GntR family transcriptional regulator ASU32_12070 ENOG4105DJ2 Major Facilitator Superfamily ASU32_12080 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ASU32_12135 ENOG4108NIW Leucine export protein LeuE ASU32_12150 ENOG4105F95 Monooxygenase ASU32_12200 ENOG4107R7A Allophanate hydrolase subunit 2 ASU32_12205 ENOG4105CSH Transporter ASU32_12210 ENOG41073TP transcriptional regulator ASU32_12220 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASU32_12225 ENOG4105N14 lysine exporter protein LysE YggA ASU32_12245 ENOG4108IG5 Transcriptional regulator ASU32_12250 ENOG4105E9K Isocitrate dehydrogenase ASU32_12255 ENOG4105CKW Inner membrane protein yedI ASU32_12275 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ASU32_12300 ENOG4105D3Q Sugar transferase ASU32_12305 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ASU32_12325 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ASU32_12370 ENOG4105CPQ Dehydrogenase ASU32_12380 ENOG4105D01 (LipO)protein ASU32_12395 ENOG4105DMF Dehydrogenase ASU32_12420 ENOG4105DZ6 Band 7 protein ASU32_12430 ENOG4105C57 major facilitator superfamily ASU32_12460 ENOG4105C7H Helicase, RecD TraA family ASU32_12465 ENOG4107QKA exodeoxyribonuclease V beta ASU32_12490 ENOG4105PMW Domain of unknown function (DUF1990) ASU32_12500 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ASU32_12585 ENOG4105C37 (CBS) domain ASU32_12600 ENOG4105EHG Permease protein ASU32_12605 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) ASU32_12615 ENOG41064B9 (LipO)protein ASU32_12630 ENOG4105IBP Cyclic peptide transporter ASU32_12665 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASU32_12675 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ASU32_12700 ENOG4108UW8 fha domain-containing protein ASU32_12705 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ASU32_12715 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASU32_12720 ENOG4105IIU Aminopeptidase ASU32_12730 ENOG4105D74 hydrolase ASU32_12750 ENOG4108X0B nad(p)h dehydrogenase (quinone) ASU32_12760 ENOG4105D8V Glucose sorbosone dehydrogenase ASU32_12770 ENOG4105M2Z protein tyrosine serine phosphatase ASU32_12800 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ASU32_12805 ENOG4105CAT Cytidine monophosphate kinase ASU32_12820 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ASU32_12825 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) ASU32_12840 ENOG4108YZ4 nudix hydrolase ASU32_12845 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ASU32_12865 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ASU32_12880 ENOG4105DSU hydrolase ASU32_12905 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASU32_12920 ENOG4105W49 UPF0434 protein ASU32_12935 ENOG4108KEZ Dehydrogenase ASU32_12945 ENOG4108KEZ Dehydrogenase ASU32_12950 ENOG4105CJ1 ABC, transporter ASU32_12960 ENOG4108RZE Tetr family transcriptional regulator ASU32_12965 ENOG4105CH7 arginosuccinase ASU32_12970 ENOG4105CDH Citrulline--aspartate ligase ASU32_12985 ENOG4105C8Y Acetylornithine aminotransferase ASU32_12990 ENOG4105CAS nag kinase ASU32_12995 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) ASU32_13000 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ASU32_13035 ENOG4107RR1 TRANSCRIPTIONal ASU32_13040 ENOG4105CHR reductase ASU32_13045 ENOG4107RR1 TRANSCRIPTIONal ASU32_13050 ENOG4105CAY ferredoxin--nadp reductase ASU32_13065 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASU32_13070 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ASU32_13075 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ASU32_13110 ENOG4105C2W permease ASU32_13125 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ASU32_13130 ENOG41084BS 50S ribosomal protein L35 ASU32_13170 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_13180 ENOG4105C57 major facilitator superfamily ASU32_13190 ENOG4108FPN Integrase ASU32_13230 ENOG4105C5X domain protein ASU32_13250 ENOG4105CIR epoxide hydrolase ASU32_13260 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ASU32_13275 ENOG4105EEM helicase ASU32_13305 ENOG4105C0D helicase ASU32_13315 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ASU32_13330 ENOG4105DEI Mannitol dehydrogenase ASU32_13335 ENOG4105CPQ Dehydrogenase ASU32_13395 ENOG4107RRE RNA-directed DNA polymerase ASU32_13435 ENOG4106178 UPF0339 protein ASU32_13445 ENOG4108Z6Z Transcriptional regulator ASU32_13450 ENOG4105HSS phospholipase C ASU32_13460 ENOG4105C57 major facilitator superfamily ASU32_13475 ENOG4108J2P Alpha beta hydrolase fold ASU32_13485 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASU32_13490 ENOG4105CHF Glutathione S-transferase ASU32_13515 ENOG4107FQ9 ethanolamine ammonia-lyase ASU32_13520 ENOG4105CPD ethanolamine ammonia-lyase ASU32_13530 ENOG4105CUB amino acid ASU32_13535 ENOG4108IV0 ABC, transporter ASU32_13545 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ASU32_13550 ENOG4105C32 Amino acid ABC transporter (Permease) ASU32_13595 ENOG4108KHK Glyoxalase Bleomycin resistance protein (Dioxygenase ASU32_13600 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase ASU32_13700 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASU32_13730 ENOG4107ZXI Rhomboid family ASU32_13740 ENOG4105C29 acyl-CoA thioesterase ASU32_13750 ENOG4107V6M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ASU32_13775 ENOG41080RH Thioredoxin ASU32_13785 ENOG4105C1G acyl-Coa dehydrogenase ASU32_13800 ENOG4107SET aldo keto reductase ASU32_13810 ENOG4107414 GntR family transcriptional regulator ASU32_13825 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ASU32_13845 ENOG4105VG1 fes assembly suf system protein ASU32_13850 ENOG4108UNV SUF system FeS assembly protein, NifU family ASU32_13860 ENOG4105C3K feS assembly ATPase SufC ASU32_13880 ENOG4107JC6 Membrane ASU32_13885 ENOG4105CJ1 ABC, transporter ASU32_13910 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ASU32_13915 ENOG4105EJ2 Transcriptional regulator ASU32_13925 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ASU32_13935 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ASU32_13975 ENOG4105C1G acyl-Coa dehydrogenase ASU32_13985 ENOG4105MXB limonene-12-epoxide hydrolase ASU32_13990 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ASU32_14000 ENOG4105CP7 Triose-phosphate isomerase ASU32_14005 ENOG4105BZA Phosphoglycerate kinase ASU32_14010 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASU32_14015 ENOG4105CIE May be required for sporulation (By similarity) ASU32_14020 ENOG4105CHW UPF0052 protein ASU32_14035 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ASU32_14045 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASU32_14065 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ASU32_14080 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_14120 ENOG4105DUX Transporter ASU32_14140 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ASU32_14145 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ASU32_14150 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ASU32_14180 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ASU32_14185 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASU32_14195 ENOG4107R37 Glutamate dehydrogenase ASU32_14215 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 ASU32_14245 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ASU32_14255 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ASU32_14270 ENOG4107W2M Sodium hydrogen exchanger ASU32_14280 ENOG4105SKN orotidine 5''-phosphate decarboxylase ASU32_14290 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ASU32_14305 ENOG4105CXT aspartate transcarbamylase ASU32_14310 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) ASU32_14320 ENOG410803B Involved in the transcription termination process (By similarity) ASU32_14325 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASU32_14330 ENOG4105DC7 peptidase M24 ASU32_14365 ENOG4105D49 3-dehydroquinate synthase ASU32_14370 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ASU32_14375 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ASU32_14385 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ASU32_14390 ENOG4105C98 muts2 protein ASU32_14440 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ASU32_14455 ENOG4105HDK L-asparaginase ASU32_14460 ENOG4105CZN Potassium uptake protein ASU32_14490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ASU32_14525 ENOG4105ME9 cell division protein FtsQ ASU32_14530 ENOG4105DFU Cell wall formation (By similarity) ASU32_14535 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ASU32_14550 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ASU32_14555 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ASU32_14565 ENOG4105CJN penicillin-binding protein ASU32_14575 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ASU32_14580 ENOG4108V6E Cell division protein mraZ ASU32_14605 ENOG4105R14 (LipO)protein ASU32_14615 ENOG4105CT3 Monooxygenase ASU32_14645 ENOG4105CM4 permease protein ASU32_14650 ENOG4108IPW abc transporter atp-binding protein ASU32_14655 ENOG41090CE integral membrane protein ASU32_14665 ENOG4105KYH transcriptional regulatory protein ASU32_14685 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASU32_14695 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase ASU32_14710 ENOG4105DKQ ROK family ASU32_14740 ENOG4105JNK Glycosyl transferase (Group 1 ASU32_14785 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ASU32_14790 ENOG4108I0Q anthranilate phosphoribosyltransferase ASU32_14800 ENOG4105CCU oxidase (Subunit III) ASU32_14805 ENOG4107UDY cytochrome C ASU32_14830 ENOG4108ZRS Part of cytochrome c oxidase, its function is ASU32_14835 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) ASU32_14880 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) ASU32_14900 ENOG4105CM2 brancheD-chain amino acid aminotransferase ASU32_14905 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ASU32_14910 ENOG4105C2W permease ASU32_14930 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASU32_14945 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ASU32_14970 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ASU32_14985 ENOG4105C5F glutamine synthetase ASU32_15005 ENOG4108V1T peptidylprolyl cis-trans isomerase ASU32_15020 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ASU32_15025 ENOG4105C5F glutamine synthetase ASU32_15040 ENOG4105C4K Nad synthetase ASU32_15045 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ASU32_15065 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) ASU32_15100 ENOG4105CVJ phosphoglycerate mutase ASU32_15145 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ASU32_15175 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ASU32_15190 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ASU32_15290 ENOG4105DFA alanine racemase domain protein ASU32_15300 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ASU32_15305 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ASU32_15310 ENOG4105VEQ Cold shock protein ASU32_15320 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) ASU32_15345 ENOG4105VCQ rubredoxin ASU32_15350 ENOG41084UD rubredoxin ASU32_15355 ENOG4105EEF Alkane 1-monooxygenase ASU32_15360 ENOG4105K56 Transcriptional regulator ASU32_15365 ENOG4108ZHJ Organic hydroperoxide resistance protein ASU32_15380 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ASU32_15385 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) ASU32_15425 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ASU32_15445 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASU32_15450 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) ASU32_15480 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ASU32_15495 ENOG4105HHS UPF0256 protein ASU32_15500 ENOG4108IJ6 ABC transporter ASU32_15505 ENOG4105ECW sulfate abc transporter ASU32_15510 ENOG4108I5D sulfate abc transporter ASU32_15515 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ASU32_15525 ENOG4105BZP glycoside hydrolase 15-related ASU32_15560 ENOG4105DGW oligopeptidase A ASU32_15585 ENOG4105EA8 2-Nitropropane dioxygenase ASU32_15610 ENOG4105F27 Major Facilitator ASU32_15615 ENOG4105CV8 reductase ASU32_15620 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ASU32_15630 ENOG4105C94 Transporter ASU32_15635 ENOG4105C26 Dehydrogenase ASU32_15665 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ASU32_15685 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ASU32_15700 ENOG4105KQC Competence protein ASU32_15705 ENOG4105EPR degv family ASU32_15710 ENOG4108TZC ASU32_15715 ENOG4105CVJ phosphoglycerate mutase ASU32_15725 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ASU32_15750 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ASU32_15775 ENOG4105C1G acyl-Coa dehydrogenase ASU32_15780 ENOG4107QX3 carboxylase ASU32_15795 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase ASU32_15800 ENOG4108IG5 Transcriptional regulator ASU32_15805 ENOG4105CB5 ATP-dependent DNA helicase recG ASU32_15810 ENOG4105DP4 dak2 domain fusion protein ylov ASU32_15815 ENOG4105VB9 50S ribosomal protein l28 ASU32_15820 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ASU32_15835 ENOG4105CPF Cell wall formation (By similarity) ASU32_15840 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ASU32_15845 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) ASU32_15850 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ASU32_15865 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASU32_15870 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASU32_15880 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein ASU32_15885 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) ASU32_15890 ENOG4105IW1 AmiS UreI transporter ASU32_15895 ENOG4108SY4 MarR family Transcriptional regulator ASU32_15945 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ASU32_15950 ENOG4105F0H myo-inositol catabolism protein ASU32_15955 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ASU32_15965 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) ASU32_15970 ENOG4105DH8 myo-inositol catabolism ASU32_15975 ENOG4105C26 Dehydrogenase ASU32_15990 ENOG4105FDP GntR family transcriptional regulator ASU32_16010 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASU32_16025 ENOG4107QP6 Xylose isomerase domain protein TIM barrel ASU32_16035 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ASU32_16040 ENOG4105C2J ABC transporter ASU32_16045 ENOG4105CNN ABC, transporter ASU32_16055 ENOG41060NJ transcriptional regulator ASU32_16060 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ASU32_16070 ENOG4107RJ5 oxidoreductase ASU32_16075 ENOG4107QNK )-transporter ASU32_16080 ENOG4105SHT UspA domain-containing protein ASU32_16085 ENOG4105ERH Fumarylacetoacetate hydrolase ASU32_16090 ENOG4105E5T Major Facilitator Superfamily ASU32_16095 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ASU32_16110 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_16130 ENOG4105URP P-aminobenzoate N-oxygenase AurF ASU32_16145 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ASU32_16150 ENOG4108ZP8 Acetolactate synthase small subunit ASU32_16165 ENOG4105C01 Dihydroxy-acid dehydratase ASU32_16180 ENOG4105BZU Histidine kinase ASU32_16185 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ASU32_16195 ENOG4105CTQ phosphohexokinase ASU32_16200 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_16205 ENOG4108ZGX Histidine kinase ASU32_16220 ENOG4105KPV Transcriptional regulator ASU32_16225 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ASU32_16235 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ASU32_16240 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ASU32_16250 ENOG4105KVH Transcriptional regulator ASU32_16260 ENOG4105C26 Dehydrogenase ASU32_16270 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_16275 ENOG4108Z86 Glutamine amidotransferase ASU32_16300 ENOG4105CT3 Monooxygenase ASU32_16305 ENOG4105NAE bifunctional deaminase-reductase domain protein ASU32_16345 ENOG4105C85 amino acid ASU32_16355 ENOG41088SP formiminoglutamate hydrolase ASU32_16360 ENOG4105CI2 imidazolone-5-propionate hydrolase ASU32_16365 ENOG4105CGP Urocanate hydratase ASU32_16370 ENOG4105CZE histidine utilization repressor ASU32_16380 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ASU32_16420 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ASU32_16480 ENOG4107STQ Multicopper oxidase ASU32_16485 ENOG4105BZU Histidine kinase ASU32_16490 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_16495 ENOG4105CH6 catalase ASU32_16500 ENOG4105C10 Electron transfer flavoprotein ASU32_16510 ENOG4108KQJ Type 11 methyltransferase ASU32_16535 ENOG4105EVB acetyltransferase ASU32_16555 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ASU32_16575 ENOG4105C26 Dehydrogenase ASU32_16595 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ASU32_16610 ENOG4105DKW ABC transporter ASU32_16615 ENOG4108ESZ Glycogen debranching enzyme ASU32_16620 ENOG4105EAC phosphoserine phosphatase ASU32_16635 ENOG4105URP P-aminobenzoate N-oxygenase AurF ASU32_16650 ENOG4105XDF Protein of unknown function (DUF1272) ASU32_16660 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASU32_16735 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASU32_16755 ENOG4105CXN decarboxylase ASU32_16835 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ASU32_16860 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ASU32_16870 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction ASU32_16880 ENOG4105CY3 ABC transporter, permease ASU32_16935 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASU32_16950 ENOG4108YYH Nadph-dependent fmn reductase ASU32_16970 ENOG4107QRP cobalamin biosynthesis protein CobW ASU32_16975 ENOG4105C72 UPF0176 protein ASU32_16985 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ASU32_16990 ENOG4105E2Y ABC, transporter ASU32_16995 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) ASU32_17010 ENOG4105C6Y Udp-glucose 6-dehydrogenase ASU32_17025 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase ASU32_17040 ENOG4105KVH Transcriptional regulator ASU32_17045 ENOG4105MHT Transcriptional regulator, ARSR family ASU32_17075 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) ASU32_17090 ENOG4107YPT transcriptional regulator ASU32_17110 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ASU32_17115 ENOG4105C6Z Gluconate ASU32_17120 ENOG4108UHU Aldolase ASU32_17125 ENOG4105CD3 dihydroorotase ASU32_17145 ENOG4105KME endoribonuclease L-psp ASU32_17150 ENOG4105PGM cation diffusion facilitator family transporter ASU32_17175 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ASU32_17180 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) ASU32_17185 ENOG4105CAK Cell division ATP-binding protein ftsE ASU32_17200 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ASU32_17215 ENOG4107TK4 histidinol-phosphate phosphatase ASU32_17220 ENOG4105C1G acyl-Coa dehydrogenase ASU32_17225 ENOG4105C1G acyl-Coa dehydrogenase ASU32_17230 ENOG4105BZU Histidine kinase ASU32_17235 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_17240 ENOG4105EYF MMPL domain protein ASU32_17255 ENOG4105EYM Major Facilitator superfamily ASU32_17265 ENOG410635A Membrane ASU32_17275 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ASU32_17290 ENOG4105DJZ UPF0182 protein ASU32_17300 ENOG41063PX domain protein ASU32_17330 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) ASU32_17335 ENOG4105C1G acyl-Coa dehydrogenase ASU32_17340 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ASU32_17370 ENOG4105KHC sulfurtransferase ASU32_17380 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ASU32_17385 ENOG4107SVH Potassium channel protein ASU32_17405 ENOG4108YIQ Alpha beta hydrolase ASU32_17450 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASU32_17465 ENOG4105C1J atp-dependent rna helicase ASU32_17485 ENOG4107QJE Chromosome Partitioning Protein ASU32_17490 ENOG4108ZM9 phosphoglycerate mutase ASU32_17500 ENOG4107TE5 Lipid kinase ASU32_17520 ENOG4105EMN RNA polymerase sigma factor ASU32_17530 ENOG4108Z66 YbaK ebsC protein ASU32_17550 ENOG4105C26 Dehydrogenase ASU32_17565 ENOG4108RAV Conserved protein ASU32_17570 ENOG4108Z4X TRANSCRIPTIONal ASU32_17580 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ASU32_17585 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ASU32_17655 ENOG4105E9Q Acyl-transferase ASU32_17665 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASU32_17670 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea ASU32_17685 ENOG4105MJ2 Competence protein ASU32_17690 ENOG4108MKR lipoprotein lpqb ASU32_17695 ENOG4105BZU Histidine kinase ASU32_17700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASU32_17720 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ASU32_17725 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ASU32_17730 ENOG4105C0H protease ASU32_17735 ENOG4106684 ASU32_17740 ENOG4105DU6 RNA polymerase ASU32_17745 ENOG4107ZBN O-methyltransferase ASU32_17755 ENOG41090WU lipolytic protein G-D-S-L family ASU32_17775 ENOG4107TB5 TRANSCRIPTIONal ASU32_17815 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ASU32_17825 ENOG41065SU Two-component system sensor kinase ASU32_17830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASU32_17840 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ASU32_17845 ENOG4105D8K carboxyl transferase ASU32_17855 ENOG4107WR6 Maf-like protein ASU32_17860 ENOG4105RTY Catalyzes diesterification of phthiocerol and phthiodiolone with mycocerosic acids, the final step in the phthiocerol and phthiodiolone dimycocerosate esters (PDIM) synthesis ASU32_17905 ENOG4108JIK carboxylase ASU32_17925 ENOG4108YYH Nadph-dependent fmn reductase ASU32_17955 ENOG4105ENE Histidine kinase ASU32_17975 ENOG4105EBR Carboxylesterase ASU32_17980 ENOG4107QRT dEAD DEAH box helicase ASU32_17985 ENOG41069M3 Transcriptional regulator ASU32_18005 ENOG4105WKW Pfam:DUF1458 ASU32_18025 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_18040 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ASU32_18045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASU32_18050 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ASU32_18055 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASU32_18075 ENOG4105CTQ phosphohexokinase ASU32_18095 ENOG4105E98 transcriptional regulator DeoR family ASU32_18130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ASU32_18140 ENOG4107RM1 amidohydrolase ASU32_18145 ENOG4107RM1 amidohydrolase ASU32_18160 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ASU32_18190 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ASU32_18195 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_18205 ENOG4108JQ1 Dehydrogenase ASU32_18230 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ASU32_18235 ENOG4105E33 succinate dehydrogenase ASU32_18285 ENOG4105DZ1 carboxypeptidase ASU32_18290 ENOG4105D5Q Arginine ornithine antiporter ASU32_18295 ENOG4107S2Z UPF0761 membrane protein ASU32_18300 ENOG4105C31 Tryptophanyl-tRNA synthetase ASU32_18305 ENOG4105CGK Exodeoxyribonuclease III ASU32_18320 ENOG4105F27 Major Facilitator ASU32_18340 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ASU32_18350 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ASU32_18360 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) ASU32_18400 ENOG4105C0B DNA polymerase III (alpha subunit) ASU32_18435 ENOG4108IQI permease ASU32_18450 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_18470 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ASU32_18490 ENOG4107QVP Dehydrogenase ASU32_18500 ENOG4108VT4 ASU32_18525 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ASU32_18530 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASU32_18575 ENOG4105ECQ AraC Family Transcriptional Regulator ASU32_18590 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASU32_18595 ENOG41080E2 ribosomal-protein-alanine acetyltransferase ASU32_18625 ENOG4105KZX Pterin carbinolamine dehydratase ASU32_18640 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASU32_18670 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASU32_18675 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ASU32_18680 ENOG4108UJD 30S ribosomal protein S9 ASU32_18685 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ASU32_18710 ENOG4105EC2 ftsk spoIIIe ASU32_18720 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin ASU32_18725 ENOG4107Y5K Resolvase ASU32_18815 ENOG4105DJ2 Major Facilitator Superfamily ASU32_18850 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_18855 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ASU32_18875 ENOG4105E39 Enoyl-CoA hydratase ASU32_18885 ENOG4108M8W Monooxygenase ASU32_18890 ENOG4105CSH Transporter ASU32_18910 ENOG4105EW9 transcriptional regulator AsnC family ASU32_18990 ENOG4108FN7 Aldo keto reductase ASU32_19025 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ASU32_19030 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) ASU32_19040 ENOG41060BG Tetr family transcriptional regulator ASU32_19070 ENOG4105DND Transcriptional regulator ASU32_19075 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) ASU32_19080 ENOG4105CUB amino acid ASU32_19130 ENOG4108Z6Z Transcriptional regulator ASU32_19140 ENOG4106HB6 Alpha beta hydrolase ASU32_19145 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ASU32_19170 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASU32_19235 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component ASU32_19245 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase ASU32_19250 ENOG4106NZI LysR family Transcriptional regulator ASU32_19285 ENOG4105C26 Dehydrogenase ASU32_19290 ENOG4105CI0 Citrate lyase ASU32_19295 ENOG4105DJG MaoC domain protein dehydratase ASU32_19300 ENOG4105J4Q Transcriptional regulator ASU32_19330 ENOG4106JDR secreted ASU32_19335 ENOG41082VC UPF0145 protein ASU32_19340 ENOG4107TXC Transcriptional regulator ASU32_19345 ENOG4105EYF MMPL domain protein ASU32_19355 ENOG4105C57 major facilitator superfamily ASU32_19360 ENOG4108JU3 Alkyl hydroperoxide reductase ASU32_19375 ENOG4107Z6X Transcriptional regulator ASU32_19405 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) ASU32_19425 ENOG4105CHH sulfate transporter ASU32_19495 ENOG4107QRI Phosphoketolase ASU32_19585 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ASU32_19590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASU32_19605 ENOG4108ZT0 50S ribosomal protein l17 ASU32_19610 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASU32_19615 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ASU32_19620 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ASU32_19625 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ASU32_19630 ENOG41067V7 50S ribosomal protein L36 ASU32_19640 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ASU32_19645 ENOG4105PTV Nudix Hydrolase ASU32_19665 ENOG4105K6V RNA polymerase ASU32_19675 ENOG4107TXC Transcriptional regulator ASU32_19685 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ASU32_19695 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ASU32_19700 ENOG410849U 50S ribosomal protein L30 ASU32_19705 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ASU32_19710 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ASU32_19715 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ASU32_19720 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ASU32_19755 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ASU32_19760 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ASU32_19765 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ASU32_19770 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ASU32_19805 ENOG4105C1J atp-dependent rna helicase ASU32_19820 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ASU32_19825 ENOG41082SA 50s ribosomal protein l29 ASU32_19830 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ASU32_19835 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ASU32_19845 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ASU32_19850 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ASU32_19855 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ASU32_19860 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ASU32_19865 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ASU32_19930 ENOG4108QIU Dehydrogenase ASU32_19945 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASU32_19950 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASU32_19955 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ASU32_19960 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ASU32_19980 ENOG4108M15 ABC transporter ASU32_20010 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ASU32_20020 ENOG4105F95 Monooxygenase ASU32_20040 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ASU32_20080 ENOG4108KPJ rna polymerase sigma factor ASU32_20090 ENOG4105MHT Transcriptional regulator, ARSR family ASU32_20120 ENOG4108MJN Glycosyl Transferase ASU32_20125 ENOG4108IJ9 (ABC) transporter ASU32_20130 ENOG4105BZ7 extracellular solute-binding protein family 1 ASU32_20190 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASU32_20205 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ASU32_20210 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ASU32_20215 ENOG4107NHD transcriptional regulator ASU32_20225 ENOG4105KHC sulfurtransferase ASU32_20230 ENOG4105PKJ carbohydrate binding ASU32_20235 ENOG4105DWV Homoserine O-trans-acetylase ASU32_20245 ENOG4105K6V RNA polymerase ASU32_20250 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASU32_20260 ENOG4105CF1 Alkylated DNA repair protein ASU32_20275 ENOG4105C2J ABC transporter ASU32_20280 ENOG4105CNN ABC, transporter ASU32_20285 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator ASU32_20295 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands ASU32_20305 ENOG4105CIG ABC transporter ASU32_20330 ENOG4108IXY short-chain dehydrogenase reductase ASU32_20335 ENOG4108JJ8 (ABC) transporter ASU32_20340 ENOG4108JJ9 ABC, transporter ASU32_20345 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASU32_20350 ENOG4105C4M (Ubiquinol oxidase) subunit I ASU32_20360 ENOG4105C85 amino acid ASU32_20365 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ASU32_20370 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ASU32_20385 ENOG4105CXB phosphoribosylaminoimidazole synthetase ASU32_20400 ENOG4105ETE Transcriptional regulator (LacI family ASU32_20410 ENOG4105EFZ amidohydrolase ASU32_20435 ENOG4105ECP epimerase ASU32_20450 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ASU32_20480 ENOG4105BZU Histidine kinase ASU32_20485 ENOG4105C85 amino acid ASU32_20490 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii ASU32_20500 ENOG4105C11 sulfate adenylyltransferase), subunit 2 ASU32_20515 ENOG4105CHR reductase ASU32_20530 ENOG4107QJT sodium dicarboxylate symporter ASU32_20535 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASU32_20540 ENOG4108MRH transcriptional regulatory protein ASU32_20545 ENOG4105DEF Extracellular solute-binding protein, family 5 ASU32_20550 ENOG4108JQ6 ABC transporter ASU32_20555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASU32_20570 ENOG4105CTU Proline racemase ASU32_20575 ENOG4105CPQ Dehydrogenase ASU32_20595 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ASU32_20600 ENOG4105C85 amino acid ASU32_20610 ENOG4105CHR reductase ASU32_20615 ENOG4105CPQ Dehydrogenase ASU32_20620 ENOG4105DFM M18 family aminopeptidase ASU32_20625 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I ASU32_20630 ENOG410839H phosphoribosylformylglycinamidine synthase ASU32_20650 ENOG4108V06 Glutathione peroxidase ASU32_20660 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASU32_20675 ENOG4105C8V SAICAR synthetase ASU32_20685 ENOG4105C83 adenylosuccinate lyase ASU32_20710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASU32_20720 ENOG4105EUB pirin domain protein ASU32_20725 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ASU32_20740 ENOG41082A2 Alpha beta hydrolase ASU32_20770 ENOG4105E39 Enoyl-CoA hydratase ASU32_20800 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase ASU32_20820 ENOG4107R4N Cell wall formation (By similarity) ASU32_20855 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ASU32_20860 ENOG4105CIY formyltetrahydrofolate deformylase ASU32_20885 ENOG4106BRA Membrane ASU32_20890 ENOG4105CSR polyphosphate kinase 2 ASU32_20910 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ASU32_20915 ENOG4105DUM transcriptional regulator, lysR family ASU32_20920 ENOG4107QVI Methyltransferase, type 11 ASU32_20925 ENOG4105C3M thioredoxin reductase ASU32_20935 ENOG4107RPH Isocitrate lyase ASU32_20955 ENOG4105EV8 ectoine hydroxylase ASU32_20980 ENOG4105NQG DoxX ASU32_21015 ENOG4105CSR polyphosphate kinase 2 ASU32_21025 ENOG4105BZ1 (ABC) transporter ASU32_21030 ENOG4105BZ1 (ABC) transporter ASU32_21040 ENOG4105WQI isochorismatase ASU32_21045 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ASU32_21050 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ASU32_21055 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ASU32_21060 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) ASU32_21075 ENOG4105WQI isochorismatase ASU32_21125 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ASU32_21130 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASU32_21140 ENOG4105C2N RNA methyltransferase TrmH family group 3 ASU32_21150 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ASU32_21165 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme ASU32_21190 ENOG4105D65 subunit l ASU32_21195 ENOG4105MKQ Monovalent cation H antiporter subunit C ASU32_21200 ENOG4108JPZ Monovalent cation H antiporter subunit D ASU32_21215 ENOG4105KJM monovalent cation h antiporter subunit g ASU32_21245 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) ASU32_21250 ENOG4105EHG Permease protein ASU32_21255 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) ASU32_21275 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASU32_21295 ENOG4108IUW ABC transporter ASU32_21305 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ASU32_21310 ENOG4105DWF phosphomethylpyrimidine kinase ASU32_21320 ENOG4105DWF phosphomethylpyrimidine kinase ASU32_21335 ENOG4105CIG ABC transporter ASU32_21355 ENOG4105CSH Transporter ASU32_21370 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ASU32_21380 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ASU32_21400 ENOG4105CT1 (ABC) transporter ASU32_21405 ENOG4107Q25 Serine Threonine protein kinase ASU32_21410 ENOG4107STQ Multicopper oxidase ASU32_21415 ENOG4105E0A ABC, transporter ASU32_21420 ENOG4105TVJ transport system, permease ASU32_21425 ENOG4105DQ5 transport system permease protein ASU32_21435 ENOG4105F8J Adenylate Guanylate cyclase ASU32_21440 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASU32_21450 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ASU32_21460 ENOG4108IGT Dipeptidase ASU32_21465 ENOG4105BZ1 (ABC) transporter ASU32_21520 ENOG4105CHP RNA polymerase ASU32_21525 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase ASU32_21530 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ASU32_21540 ENOG4105E2X shikimate dehydrogenase ASU32_21550 ENOG4105C1B dTDP-glucose 4-6-dehydratase ASU32_21555 ENOG4108SGK Tetr family transcriptional regulator ASU32_21560 ENOG4105CY3 ABC transporter, permease ASU32_21600 ENOG4105D2B acyl-CoA dehydrogenase ASU32_21605 ENOG4105IKQ hydratase ASU32_21635 ENOG4107HP6 Transcriptional regulator ASU32_21640 ENOG4105CPQ Dehydrogenase ASU32_21665 ENOG4105X7H acyl-CoA dehydrogenase ASU32_21670 ENOG4108KC2 acyl-Coa dehydrogenase ASU32_21675 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) ASU32_21680 ENOG4105J5T Amp-dependent synthetase and ligase ASU32_21685 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) ASU32_21705 ENOG4105C26 Dehydrogenase ASU32_21710 ENOG4105DYW oxidoreductase ASU32_21735 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_21770 ENOG4105CFC Transporter ASU32_21780 ENOG4106A3M Cytochrome p-450 ASU32_21785 ENOG4105F2C Acetyl-CoA acetyltransferase ASU32_21795 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr ASU32_21805 ENOG4105E39 Enoyl-CoA hydratase ASU32_21820 ENOG4105EA8 2-Nitropropane dioxygenase ASU32_21835 ENOG4105CHU acetyl-coa acetyltransferase ASU32_21840 ENOG4108RZE Tetr family transcriptional regulator ASU32_21845 ENOG4105CHR reductase ASU32_21850 ENOG4105CC9 acyl-Coa dehydrogenase ASU32_21855 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_21865 ENOG4105CC9 acyl-Coa dehydrogenase ASU32_21875 ENOG4105D2B acyl-CoA dehydrogenase ASU32_21880 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) ASU32_21890 ENOG4105MXW flavin reductase domain protein, FMN-binding ASU32_21895 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase ASU32_21900 ENOG41088PD hydrolase ASU32_21905 ENOG4108KC1 acyl-Coa dehydrogenase ASU32_21910 ENOG4107EFR Flavocytochrome c ASU32_21920 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein ASU32_21925 ENOG4105CIJ rieske 2fe-2S domain-containing protein ASU32_21955 ENOG4105X7H acyl-CoA dehydrogenase ASU32_22010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ASU32_22015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASU32_22025 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein ASU32_22030 ENOG4107QI1 Mate efflux family protein ASU32_22050 ENOG4105G9B Transcriptional regulator ASU32_22055 ENOG4105CT3 Monooxygenase ASU32_22070 ENOG4107QRG dna polymerase iii ASU32_22080 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASU32_22095 ENOG4105VEQ Cold shock protein ASU32_22100 ENOG4108I5C dEAD DEAH box helicase ASU32_22115 ENOG4105BZ1 (ABC) transporter ASU32_22170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASU32_22175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASU32_22180 ENOG4108J59 Extracellular solute-binding protein, family 5 ASU32_22185 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASU32_22210 ENOG4108VCA G U mismatch-specific DNA glycosylase ASU32_22215 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ASU32_22220 ENOG4105CSH Transporter ASU32_22225 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASU32_22245 ENOG4105P8F nudix hydrolase ASU32_22250 ENOG4105K63 Thioredoxin ASU32_22270 ENOG4105C7F AcnD-accessory protein PrpF ASU32_22275 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ASU32_22295 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ASU32_22300 ENOG4108JQC penicillin-binding protein 1A ASU32_22305 ENOG4105CSU acyl-Coa dehydrogenase ASU32_22320 ENOG4105E39 Enoyl-CoA hydratase ASU32_22340 ENOG4107Y80 Major Facilitator superfamily ASU32_22370 ENOG4105DIN metallophosphoesterase ASU32_22385 ENOG41083TI Protein CrcB homolog ASU32_22390 ENOG4107JBM CrcB-like protein ASU32_22395 ENOG4108ZHJ Organic hydroperoxide resistance protein ASU32_22420 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_22430 ENOG4106NZI LysR family Transcriptional regulator ASU32_22440 ENOG4105CJN penicillin-binding protein ASU32_22450 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase ASU32_22465 ENOG41090A1 ferritin ASU32_22470 ENOG4107Z3H Transcriptional regulator, TetR family ASU32_22490 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ASU32_22510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASU32_22515 ENOG4105CFH Aspartokinase ASU32_22530 ENOG4105WQT MbtH domain protein ASU32_22540 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_22545 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ASU32_22555 ENOG4105T38 integral membrane protein ASU32_22560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASU32_22565 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ASU32_22585 ENOG4105DJ2 Major Facilitator Superfamily ASU32_22590 ENOG4105F04 LysR family Transcriptional regulator ASU32_22605 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ASU32_22620 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASU32_22640 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ASU32_22650 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase ASU32_22655 ENOG4105C34 Pseudouridine synthase ASU32_22670 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ASU32_22705 ENOG4105XT2 Transcriptional regulator ASU32_22720 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASU32_22750 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASU32_22785 ENOG41082YX Transcriptional regulator, arsr family ASU32_22795 ENOG4105DQE DNA ligase ASU32_22800 ENOG4105GN4 DNA ligase ASU32_22815 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ASU32_22825 ENOG4105ECQ AraC Family Transcriptional Regulator ASU32_22830 ENOG4105EYF MMPL domain protein ASU32_22855 ENOG4108Z6B deaminase ASU32_22865 ENOG4105EVN Prephenate dehydrogenase ASU32_22890 ENOG4107RR1 TRANSCRIPTIONal ASU32_22895 ENOG4105C26 Dehydrogenase ASU32_22950 ENOG4105EMN RNA polymerase sigma factor ASU32_22990 ENOG4105CIH Imidazole acetol-phosphate transaminase ASU32_23010 ENOG4105ECQ AraC Family Transcriptional Regulator ASU32_23030 ENOG410900P UPF0336 protein ASU32_23050 ENOG4105C09 Bile acid ASU32_23060 ENOG41066UM arsR family transcriptional regulator ASU32_23115 ENOG4105WH1 Two component transcriptional regulator luxr family ASU32_23120 ENOG4105D9P serine threonine protein kinase ASU32_23220 ENOG4107T65 Integrase ASU32_23230 ENOG4105CHU acetyl-coa acetyltransferase ASU32_23260 ENOG4108VC7 Protein of unknown function (DUF2587) ASU32_23275 ENOG4108MKI Glycosyl transferase, family 2 ASU32_23280 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_23290 ENOG4105MXW flavin reductase domain protein, FMN-binding ASU32_23330 ENOG4105VZ8 Transcriptional regulator ASU32_23340 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ASU32_23355 ENOG4108JPW Aminotransferase ASU32_23360 ENOG4105CH2 amidohydrolase ASU32_23370 ENOG4105C1G acyl-Coa dehydrogenase ASU32_23375 ENOG4108X07 Tetr family transcriptional regulator ASU32_23385 ENOG4108RG3 short-chain dehydrogenase reductase ASU32_23395 ENOG4105PDP Short chain dehydrogenase ASU32_23400 ENOG4108MES Periplasmic binding protein ASU32_23415 ENOG4108JJB ABC transporter ASU32_23420 ENOG4107ZYJ bioY protein ASU32_23430 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ASU32_23450 ENOG4105J1Z Arabinosyltransferase ASU32_23460 ENOG4105J1Z Arabinosyltransferase ASU32_23470 ENOG4105EBR Carboxylesterase ASU32_23475 ENOG4105C94 Transporter ASU32_23515 ENOG4105E90 ABC transporter ASU32_23520 ENOG4108IJ8 ABC transporter ASU32_23525 ENOG4105E90 ABC transporter ASU32_23530 ENOG4105EEM helicase ASU32_23555 ENOG4105EG6 Saccharopine dehydrogenase ASU32_23560 ENOG4105CEY Amp-dependent synthetase and ligase ASU32_23620 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ASU32_23635 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) ASU32_23700 ENOG4108SGK Tetr family transcriptional regulator ASU32_23715 ENOG4105CHU acetyl-coa acetyltransferase ASU32_23730 ENOG4108UKI Enoyl-CoA hydratase ASU32_23735 ENOG4105EA8 2-Nitropropane dioxygenase ASU32_23755 ENOG4105BZ4 penicillin-binding protein ASU32_23770 ENOG4105CZA synthase ASU32_23830 ENOG4105DAX Pfam:DUF2983 ASU32_23845 ENOG4105EPD Oligopeptide transporter, Opt family ASU32_23850 ENOG4105FBW Monooxygenase ASU32_23865 ENOG4105DXB Major Facilitator superfamily ASU32_23900 ENOG4105C8T Leucyl-tRNA synthetase ASU32_23915 ENOG4105DHU Bile acid ASU32_23965 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ASU32_23990 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ASU32_23995 ENOG4105C26 Dehydrogenase ASU32_24015 ENOG4105K63 Thioredoxin ASU32_24020 ENOG4108E1C hydrolase ASU32_24035 ENOG4107QJE Chromosome Partitioning Protein ASU32_24045 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ASU32_24055 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ASU32_24060 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ASU32_24065 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)