locus-tag class description CIG75_00010 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) CIG75_00015 ENOG4105MA4 psp1 domain protein CIG75_00020 ENOG4105FA2 dna polymerase iii CIG75_00025 ENOG4105XVJ Protein of unknown function (DUF327) CIG75_00030 ENOG4105X0R protein from nitrogen regulatory protein P-II CIG75_00035 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CIG75_00040 ENOG4105CXN decarboxylase CIG75_00055 ENOG41067KS pro-sigma K processing CIG75_00065 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CIG75_00070 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CIG75_00075 ENOG4105C6E dna polymerase iii CIG75_00080 ENOG4105BZU Histidine kinase CIG75_00095 ENOG4108Z6B deaminase CIG75_00125 ENOG4105ZMH deoxynucleoside kinase CIG75_00135 ENOG4107YGS glycoside hydrolase 15-related CIG75_00140 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CIG75_00145 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CIG75_00150 ENOG4105DZ1 carboxypeptidase CIG75_00155 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CIG75_00190 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CIG75_00195 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CIG75_00205 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CIG75_00210 ENOG410848D S4 domain protein YaaA CIG75_00215 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CIG75_00220 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CIG75_00230 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CIG75_00235 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CIG75_00240 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CIG75_00245 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein CIG75_00250 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CIG75_00255 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CIG75_00260 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CIG75_00270 ENOG4107QJE Chromosome Partitioning Protein CIG75_00275 ENOG4105FA0 parb-like partition protein CIG75_00315 ENOG4108ZDA Sporulation protein YyaC CIG75_00330 ENOG4105D8X mechanosensitive ion channel CIG75_00335 ENOG4105VDK protein, conserved in bacteria CIG75_00340 ENOG4108J2R molybdopterin oxidoreductase CIG75_00360 ENOG4105C3G gtp-binding protein CIG75_00365 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CIG75_00370 ENOG4108UUM single-stranded DNA-binding protein CIG75_00400 ENOG4105CHP RNA polymerase CIG75_00410 ENOG4105CZ9 Domain of unknown function (DU1801) CIG75_00425 ENOG4105BZU Histidine kinase CIG75_00430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CIG75_00450 ENOG4105DEN Luciferase family CIG75_00455 ENOG4105C5H ABC transporter CIG75_00465 ENOG4105C28 cystathionine CIG75_00470 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CIG75_00490 ENOG4108ZJ4 polysaccharide deacetylase CIG75_00505 ENOG4108IUQ atp-dependent protease CIG75_00510 ENOG4105CDU Replicative dna helicase CIG75_00520 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CIG75_00535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CIG75_00540 ENOG4105BZU Histidine kinase CIG75_00555 ENOG4105Q2H domain protein CIG75_00565 ENOG4105C0H protease CIG75_00645 ENOG4105VMP Transcriptional regulator CIG75_00655 ENOG410847I Transcriptional regulator, BadM Rrf2 family CIG75_00665 ENOG4105BZ1 (ABC) transporter CIG75_00670 ENOG4105BZ1 (ABC) transporter CIG75_00680 ENOG4105BZU Histidine kinase CIG75_00690 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CIG75_00695 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) CIG75_00715 ENOG4105M4P Tetr family transcriptional regulator CIG75_00725 ENOG41080TC multidrug resistance protein CIG75_00745 ENOG4105CHR reductase CIG75_00760 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CIG75_00775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CIG75_00790 ENOG4105CV8 reductase CIG75_00810 ENOG4105VMP Transcriptional regulator CIG75_00830 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CIG75_00845 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CIG75_00850 ENOG4105E66 phosphoriboisomerase A CIG75_00865 ENOG4105BZA Phosphoglycerate kinase CIG75_00870 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CIG75_00875 ENOG4105DJV ribulose-phosphate 3-epimerase CIG75_00920 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CIG75_00930 ENOG410874W AraC family transcriptional regulator CIG75_00950 ENOG4105NIV Esterase CIG75_00990 ENOG4105DEN Luciferase family CIG75_01000 ENOG4105DAP Nicotinate phosphoribosyltransferase CIG75_01005 ENOG4105CMR udp-glucose 4-epimerase CIG75_01020 ENOG4107Y03 Nitroreductase CIG75_01025 ENOG4105DHS permease protein CIG75_01030 ENOG4105CM4 permease protein CIG75_01035 ENOG4108IPW abc transporter atp-binding protein CIG75_01045 ENOG4108JJB ABC transporter CIG75_01050 ENOG4108V4M Cobalt abc transporter CIG75_01060 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CIG75_01095 ENOG4108SHJ s-layer protein CIG75_01100 ENOG4107TXC Transcriptional regulator CIG75_01115 ENOG4105FE9 pseudouridine synthase CIG75_01120 ENOG4105VCH membrane CIG75_01125 ENOG4105C1J atp-dependent rna helicase CIG75_01135 ENOG4105C5H ABC transporter CIG75_01155 ENOG4105CQ7 ATP-dependent helicase CIG75_01215 ENOG4107TVC Glycosyl transferase, family 2 CIG75_01225 ENOG4106WTF Glycosyl transferase, family 2 CIG75_01235 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CIG75_01250 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CIG75_01265 ENOG4108ZCF integral membrane protein CIG75_01270 ENOG4105BZU Histidine kinase CIG75_01275 ENOG4105C72 UPF0176 protein CIG75_01280 ENOG410605W Major Facilitator CIG75_01290 ENOG4105C37 (CBS) domain CIG75_01295 ENOG4105G0J serine threonine protein kinase CIG75_01305 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CIG75_01330 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CIG75_01335 ENOG4105CZM Major Facilitator CIG75_01340 ENOG4107ZXU DSBA oxidoreductase CIG75_01345 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CIG75_01355 ENOG4105BZ1 (ABC) transporter CIG75_01360 ENOG4105BZ1 (ABC) transporter CIG75_01370 ENOG4105KHC sulfurtransferase CIG75_01385 ENOG4105E1K spore germination protein CIG75_01390 ENOG4108Q5U germination protein, ger(x)c family CIG75_01430 ENOG4105BZ4 penicillin-binding protein CIG75_01435 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CIG75_01440 ENOG4105CYW agmatinase CIG75_01475 ENOG41087NI Sulfite exporter TauE/SafE CIG75_01480 ENOG4107TPS domain protein CIG75_01485 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CIG75_01490 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CIG75_01495 ENOG4105XTG Pfam:DUF156 CIG75_01530 ENOG4108JUB Transcriptional regulator CIG75_01535 ENOG4105FRY Dehydrogenase CIG75_01540 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CIG75_01550 ENOG4105C98 muts2 protein CIG75_01555 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit CIG75_01560 ENOG4107CHF 5,6-aminomutase beta subunit CIG75_01580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CIG75_01600 ENOG4105DF6 Fe-S oxidoreductase CIG75_01610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CIG75_01615 ENOG4105E39 Enoyl-CoA hydratase CIG75_01620 ENOG4105C1G acyl-Coa dehydrogenase CIG75_01625 ENOG4105C1G acyl-Coa dehydrogenase CIG75_01640 ENOG4108UK2 deaminase CIG75_01670 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CIG75_01675 ENOG4108UGV hypoxanthine phosphoribosyltransferase CIG75_01680 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CIG75_01690 ENOG4105CKU formyltetrahydrofolate synthetase CIG75_01695 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CIG75_01700 ENOG4108IYU L-aspartate oxidase CIG75_01705 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CIG75_01710 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CIG75_01715 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CIG75_01720 ENOG410812K response regulator receiver protein CIG75_01725 ENOG4108UYI beta-alanyl-CoA ammonia lyase CIG75_01730 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme CIG75_01740 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CIG75_01745 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CIG75_01750 ENOG4105CH2 amidohydrolase CIG75_01765 ENOG4105CBT Fructose-1,6-bisphosphatase CIG75_01770 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CIG75_01790 ENOG41082DI 50s ribosomal protein l31 CIG75_01795 ENOG4107104 thymidine kinase CIG75_01810 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CIG75_01815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CIG75_01820 ENOG4108ZXQ stage ii sporulation protein r CIG75_01830 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CIG75_01860 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CIG75_01870 ENOG4105BZ1 (ABC) transporter CIG75_01875 ENOG4108YZG isomerase CIG75_01880 ENOG4108UIC UPF0340 protein CIG75_01885 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CIG75_01890 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CIG75_01895 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CIG75_01905 ENOG4105CHU acetyl-coa acetyltransferase CIG75_01915 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CIG75_01920 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CIG75_01925 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CIG75_01930 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CIG75_01935 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CIG75_01940 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CIG75_01945 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CIG75_01950 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CIG75_01955 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CIG75_01960 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CIG75_01965 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CIG75_01970 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CIG75_01975 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CIG75_01980 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CIG75_01985 ENOG4107YX3 NADH dehydrogenase subunit j CIG75_01990 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CIG75_01995 ENOG4105D65 subunit l CIG75_02000 ENOG4105C8S subunit m CIG75_02005 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CIG75_02020 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CIG75_02035 ENOG4105FRN stage II sporulation protein CIG75_02040 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CIG75_02045 ENOG4105DFF Rod shape-determining protein mreb CIG75_02055 ENOG4105CGA flagellar basal-body rod protein FlgG CIG75_02065 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CIG75_02070 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_02080 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CIG75_02095 ENOG4107T8Q Glycosyl transferase (Group 1 CIG75_02120 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) CIG75_02125 ENOG4105CN1 protease CIG75_02150 ENOG4106YN8 Prenyltransferase CIG75_02180 ENOG4108KGH TRANSCRIPTIONal CIG75_02195 ENOG4108KGH TRANSCRIPTIONal CIG75_02205 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CIG75_02210 ENOG4108JYZ YitT family CIG75_02235 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_02240 ENOG4105BZU Histidine kinase CIG75_02245 ENOG4105CVA phosphate CIG75_02250 ENOG4105C8U phosphate abc transporter CIG75_02255 ENOG4105E2Z phosphate ABC transporter (Permease CIG75_02260 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CIG75_02265 ENOG4108UTW Plays a role in the regulation of phosphate uptake CIG75_02270 ENOG4105C7H Helicase, RecD TraA family CIG75_02275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CIG75_02280 ENOG4105BZU Histidine kinase CIG75_02300 ENOG4108IMY Transcriptional regulator CIG75_02330 ENOG4105MJ2 Competence protein CIG75_02350 ENOG4105E1Q flagellar hook-associated protein CIG75_02355 ENOG4105DTJ flagellar hook-associated protein CIG75_02365 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) CIG75_02370 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CIG75_02375 ENOG4105I03 Flagellin CIG75_02380 ENOG4105I03 Flagellin CIG75_02390 ENOG4107RT6 flagellar hook-associated CIG75_02415 ENOG4108IAJ Nad-dependent epimerase dehydratase CIG75_02420 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CIG75_02425 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase CIG75_02430 ENOG4105C3I Nad-dependent epimerase dehydratase CIG75_02435 ENOG4107YEI lmbE family CIG75_02440 ENOG4105D2T synthase CIG75_02445 ENOG4108S0S Nucleotidyl transferase CIG75_02450 ENOG4105F0R Cytidylyltransferase CIG75_02470 ENOG4106D4I domain protein CIG75_02475 ENOG41066UZ arginase EC 3.5.3.1 CIG75_02480 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CIG75_02485 ENOG4107TSN permease CIG75_02490 ENOG4107RIQ Sulfate adenylate transferase CIG75_02495 ENOG4105EMN RNA polymerase sigma factor CIG75_02510 ENOG4105C8B TIGR00159 family CIG75_02520 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CIG75_02525 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CIG75_02540 ENOG41086D8 Transcriptional regulator CIG75_02545 ENOG4105EHG Permease protein CIG75_02550 ENOG4105E0A ABC, transporter CIG75_02560 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CIG75_02580 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CIG75_02610 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CIG75_02615 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CIG75_02620 ENOG4107QYV phosphohexose isomerase CIG75_02635 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CIG75_02640 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CIG75_02680 ENOG4107Y80 Major Facilitator superfamily CIG75_02725 ENOG4105K7K Transcriptional regulator CIG75_02790 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CIG75_02795 ENOG4107SQU synthase CIG75_02800 ENOG4105C0W non-ribosomal peptide synthetase CIG75_02805 ENOG4105C0W non-ribosomal peptide synthetase CIG75_02830 ENOG4105N14 lysine exporter protein LysE YggA CIG75_02845 ENOG41081VB Hydrolase CIG75_02850 ENOG4107SFI Major Facilitator superfamily CIG75_02855 ENOG4105DJU Siderophore biosynthesis protein CIG75_02860 ENOG4105C6X Major Facilitator CIG75_02865 ENOG4105DUU IucA IucC family protein CIG75_02875 ENOG41067FT ParB-like nuclease domain CIG75_02885 ENOG4107GBW cellulosome anchoring protein cohesin CIG75_02910 ENOG4108N0M stress protein CIG75_02915 ENOG4106FN3 tellurium resistance protein CIG75_02920 ENOG4106FN3 tellurium resistance protein CIG75_02925 ENOG4106FN3 tellurium resistance protein CIG75_02930 ENOG4107TS3 membrane protein, TerC CIG75_02945 ENOG4105DAX Pfam:DUF2983 CIG75_02975 ENOG4105BZU Histidine kinase CIG75_02980 ENOG4105EYF MMPL domain protein CIG75_03000 ENOG4108IJ6 ABC transporter CIG75_03005 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CIG75_03010 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CIG75_03015 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CIG75_03020 ENOG4105C0X amino acid CIG75_03035 ENOG4105C0R drug resistance transporter emrb qaca subfamily CIG75_03040 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CIG75_03045 ENOG410839T multidrug resistance protein CIG75_03050 ENOG41080TC multidrug resistance protein CIG75_03060 ENOG4105CZM Major Facilitator CIG75_03065 ENOG4105EEM helicase CIG75_03075 ENOG4108VXD carboxy-peptidase CIG75_03080 ENOG4105EEM helicase CIG75_03085 ENOG4105DQ6 Transposase CIG75_03140 ENOG4105X7F CIG75_03155 ENOG4108T86 baseplate J family protein CIG75_03195 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CIG75_03245 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CIG75_03265 ENOG41087YS Phage shock protein A CIG75_03275 ENOG4105ENE Histidine kinase CIG75_03280 ENOG4105WH1 Two component transcriptional regulator luxr family CIG75_03290 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein CIG75_03305 ENOG4105CPF Cell wall formation (By similarity) CIG75_03310 ENOG4107Z3H Transcriptional regulator, TetR family CIG75_03315 ENOG41082BM Transcriptional regulator, arsr family CIG75_03335 ENOG4107YT1 Glutamate mutase subunit sigma CIG75_03360 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CIG75_03365 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CIG75_03370 ENOG4105CQB FAD linked oxidase domain protein CIG75_03375 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CIG75_03385 ENOG4105BZ1 (ABC) transporter CIG75_03395 ENOG4107RQ2 Cytochrome c oxidase, subunit I CIG75_03400 ENOG4105NAA Cytochrome C oxidase, subunit II CIG75_03405 ENOG4105WH1 Two component transcriptional regulator luxr family CIG75_03410 ENOG4105BZU Histidine kinase CIG75_03420 ENOG41080BT SNARE associated Golgi CIG75_03425 ENOG4106F1P AAA ATPase, central domain protein CIG75_03430 ENOG4105CH7 arginosuccinase CIG75_03435 ENOG410880H cysteine synthase CIG75_03465 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CIG75_03470 ENOG4108JQ7 (ABC) transporter CIG75_03485 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CIG75_03490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CIG75_03500 ENOG4105FGV Chromate CIG75_03505 ENOG4108DBC nitroreductase CIG75_03525 ENOG4105BZU Histidine kinase CIG75_03530 ENOG4105WH1 Two component transcriptional regulator luxr family CIG75_03535 ENOG4105CJ1 ABC, transporter CIG75_03540 ENOG41090VJ ABC-2 type transporter CIG75_03545 ENOG41090VJ ABC-2 type transporter CIG75_03550 ENOG4108KYE ABC-2 type transporter CIG75_03560 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CIG75_03570 ENOG4105BZW Glycerate kinase CIG75_03575 ENOG4107SFI Major Facilitator superfamily CIG75_03585 ENOG4108RPX mosc domain containing protein CIG75_03605 ENOG4105EEM helicase CIG75_03625 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CIG75_03630 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CIG75_03635 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CIG75_03640 ENOG4107QRT dEAD DEAH box helicase CIG75_03645 ENOG4105KGF protein, YerC YecD CIG75_03650 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CIG75_03670 ENOG4105DZP Membrane-associated zinc metalloprotease CIG75_03680 ENOG4105C4R Atp-dependent dna helicase CIG75_03685 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CIG75_03690 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CIG75_03695 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CIG75_03705 ENOG4105VBH UPF0297 protein CIG75_03710 ENOG4105ESV Glycosyl transferase, family 4 CIG75_03715 ENOG4105K8R UPF0145 protein CIG75_03725 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CIG75_03735 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_03740 ENOG4105BZU Histidine kinase CIG75_03745 ENOG4105CNG UPF0061 protein CIG75_03765 ENOG4105E0X reductase CIG75_03805 ENOG4107X2D transcriptional regulator, merr family CIG75_03810 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase CIG75_03815 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CIG75_03825 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CIG75_03830 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CIG75_03835 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CIG75_03840 ENOG4105CBD Diacylglycerol kinase CIG75_03850 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CIG75_03910 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CIG75_03920 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CIG75_03925 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CIG75_03965 ENOG4105F0F Oxalate decarboxylase CIG75_03985 ENOG4105DQ6 Transposase CIG75_04005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CIG75_04015 ENOG4105D03 DNA-3-methyladenine glycosylase II CIG75_04025 ENOG4105D9U N-acetyltransferase CIG75_04030 ENOG4105I3N Conserved Protein CIG75_04050 ENOG41068WN CIG75_04065 ENOG4105WH1 Two component transcriptional regulator luxr family CIG75_04070 ENOG4105ENE Histidine kinase CIG75_04085 ENOG4105C26 Dehydrogenase CIG75_04100 ENOG4105FBW Monooxygenase CIG75_04105 ENOG4105BZU Histidine kinase CIG75_04150 ENOG4105VRS hydrolase family 18 CIG75_04170 ENOG4108UXE Protein tyrosine phosphatase CIG75_04175 ENOG4107R5R arsenical pump membrane protein CIG75_04180 ENOG41082YX Transcriptional regulator, arsr family CIG75_04185 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CIG75_04240 ENOG4105T0Z Conserved Protein CIG75_04255 ENOG410890F Dynamin family CIG75_04260 ENOG410890F Dynamin family CIG75_04280 ENOG4108Z18 K06886 hemoglobin CIG75_04285 ENOG410834F Transcriptional regulator CIG75_04290 ENOG4105C0R drug resistance transporter emrb qaca subfamily CIG75_04295 ENOG41082BM Transcriptional regulator, arsr family CIG75_04300 ENOG4105CPC Aldo Keto reductase CIG75_04320 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CIG75_04360 ENOG4105DFU Cell wall formation (By similarity) CIG75_04365 ENOG4105I6B RNA polymerase CIG75_04385 ENOG4105C75 arginyL-tRNA synthetase CIG75_04390 ENOG4105BZU Histidine kinase CIG75_04415 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CIG75_04425 ENOG4105EB3 Histidine kinase CIG75_04430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CIG75_04445 ENOG4105E39 Enoyl-CoA hydratase CIG75_04460 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_04475 ENOG4105C9U ATP-dependent DNA helicase RecQ CIG75_04485 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CIG75_04500 ENOG4105DQ6 Transposase CIG75_04520 ENOG4105D9U N-acetyltransferase CIG75_04535 ENOG4105D9U N-acetyltransferase CIG75_04560 ENOG4105II7 pyrroline-5-carboxylate reductase CIG75_04570 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CIG75_04575 ENOG4105C5H ABC transporter CIG75_04580 ENOG4105ETU transcriptional activator (TenA CIG75_04595 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CIG75_04615 ENOG4105CTD carboxy-peptidase CIG75_04620 ENOG4105VEQ Cold shock protein CIG75_04630 ENOG4108ZCF integral membrane protein CIG75_04650 ENOG41065KQ synthase CIG75_04660 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CIG75_04665 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CIG75_04685 ENOG4105G9B Transcriptional regulator CIG75_04695 ENOG4105DKQ ROK family CIG75_04715 ENOG4107G87 m6 family metalloprotease domain protein CIG75_04720 ENOG4105D7K pfkb domain protein CIG75_04745 ENOG4108TGP Thioesterase superfamily protein CIG75_04750 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CIG75_04760 ENOG4105HIR S-layer domain protein CIG75_04775 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CIG75_04805 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CIG75_04875 ENOG4105D9U N-acetyltransferase CIG75_04890 ENOG4108V2W Carbonate dehydratase CIG75_04900 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CIG75_04910 ENOG4105EMN RNA polymerase sigma factor CIG75_04935 ENOG41082F9 transcriptional regulator CIG75_04945 ENOG4105C88 aminopeptidase CIG75_04950 ENOG4105CEN a g-specific adenine glycosylase CIG75_04975 ENOG4106I4J membrane CIG75_04995 ENOG4105JXH GntR family transcriptional regulator CIG75_05000 ENOG4108JYZ YitT family CIG75_05015 ENOG4105HTX biosynthesis protein CIG75_05020 ENOG4108PQP glycosyl transferase group 1 CIG75_05030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CIG75_05035 ENOG4105BZU Histidine kinase CIG75_05080 ENOG4105C26 Dehydrogenase CIG75_05115 ENOG4105CAN Short-chain dehydrogenase reductase Sdr CIG75_05150 ENOG4108SHJ s-layer protein CIG75_05155 ENOG4108VCI transcription factor, rsfa family CIG75_05160 ENOG4108KP7 hydrolase CIG75_05185 ENOG4105CNA YD repeat protein CIG75_05200 ENOG4105KT7 mgtC SapB transporter CIG75_05230 ENOG4105C5I Dehydrogenase CIG75_05255 ENOG4107R8B 5'-nucleotidase CIG75_05260 ENOG4105CSM endonuclease III CIG75_05280 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase CIG75_05285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CIG75_05300 ENOG4105CHM Aminotransferase CIG75_05310 ENOG4108IG5 Transcriptional regulator CIG75_05315 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CIG75_05320 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CIG75_05325 ENOG4105EWC Purine nucleoside phosphorylase CIG75_05335 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CIG75_05340 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CIG75_05345 ENOG4107258 Transcriptional regulator CIG75_05355 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CIG75_05360 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CIG75_05375 ENOG4105DA5 (ABC) transporter CIG75_05380 ENOG4105ECB domain protein CIG75_05390 ENOG4105CYN Serine protein kinase CIG75_05400 ENOG4105ED1 spovr family CIG75_05430 ENOG4108W8W CRISPR-associated RAMP protein, Csm3 family CIG75_05475 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CIG75_05485 ENOG4106MP8 UPF0754 membrane protein CIG75_05490 ENOG41084CE UPF0342 protein CIG75_05495 ENOG4105E8R UPF0173 metal-dependent hydrolase CIG75_05500 ENOG4105XZV Protein of unknown function (DUF3243) CIG75_05520 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CIG75_05525 ENOG4105C0B DNA polymerase III (alpha subunit) CIG75_05535 ENOG4105C6K Malic enzyme CIG75_05545 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CIG75_05550 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CIG75_05555 ENOG4105CTQ phosphohexokinase CIG75_05570 ENOG4105FS0 cytoplasmic membrane protein CIG75_05580 ENOG4108HMX isocitrate dehydrogenase (NADP) CIG75_05585 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CIG75_05590 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CIG75_05595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CIG75_05605 ENOG4108JQ7 (ABC) transporter CIG75_05610 ENOG4105C2M dna polymerase I CIG75_05615 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CIG75_05625 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CIG75_05640 ENOG4108UGV hypoxanthine phosphoribosyltransferase CIG75_05650 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CIG75_05660 ENOG4105BZN citrate synthase CIG75_05690 ENOG41080XP Cbs domain CIG75_05695 ENOG41080XP Cbs domain CIG75_05710 ENOG4107RFW hydrolase family 57 CIG75_05740 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) CIG75_05750 ENOG4105FAA peptidase M23 CIG75_05760 ENOG4105CJ3 phosphate transporter CIG75_05785 ENOG4107QW4 alcohol dehydrogenase CIG75_05790 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CIG75_05795 ENOG4105CHM Aminotransferase CIG75_05800 ENOG41060WC Enoyl-CoA hydratase CIG75_05815 ENOG4105VDT -acetyltransferase CIG75_05845 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CIG75_05950 ENOG4105K4H Nlp p60 protein CIG75_05955 ENOG4105C2J ABC transporter CIG75_05970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CIG75_05975 ENOG4105BZU Histidine kinase CIG75_05990 ENOG4105VJV 50s ribosomal protein L35 CIG75_05995 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CIG75_06000 ENOG4107ZYR domain protein CIG75_06005 ENOG4108RWN rrna methyltransferase CIG75_06015 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CIG75_06020 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CIG75_06025 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CIG75_06040 ENOG4105C98 muts2 protein CIG75_06045 ENOG4105BZ4 penicillin-binding protein CIG75_06050 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CIG75_06100 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase CIG75_06105 ENOG4105C8M UPF0272 protein CIG75_06225 ENOG4105CPF Cell wall formation (By similarity) CIG75_06255 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CIG75_06260 ENOG4108UMI ABC transporter, permease CIG75_06265 ENOG4105D01 (LipO)protein CIG75_06285 ENOG4105C6X Major Facilitator CIG75_06290 ENOG4106K7D Major facilitator family transporter CIG75_06295 ENOG4107RU9 Transcriptional regulator, Crp Fnr family CIG75_06310 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CIG75_06315 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CIG75_06320 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CIG75_06325 ENOG4108WZW RNA polymerase sigma CIG75_06330 ENOG41086IN PA14 CIG75_06335 ENOG4105CPI Metal Dependent Phosphohydrolase CIG75_06340 ENOG4105JFG SpoIID LytB domain protein CIG75_06350 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CIG75_06355 ENOG4105VIE preprotein translocase, subunit YajC CIG75_06365 ENOG4105BZU Histidine kinase CIG75_06370 ENOG4108QG2 Membrane CIG75_06375 ENOG4105CKP Polysaccharide Biosynthesis Protein CIG75_06390 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CIG75_06395 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CIG75_06400 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CIG75_06405 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CIG75_06410 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CIG75_06415 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CIG75_06440 ENOG4105C2C drug resistance transporter, Bcr CflA CIG75_06490 ENOG41067V3 Antibiotic biosynthesis monooxygenase CIG75_06495 ENOG4105DJ2 Major Facilitator Superfamily CIG75_06525 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CIG75_06530 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CIG75_06535 ENOG4105DTD Dehydrogenase CIG75_06585 ENOG4105DPN Oligoendopeptidase f CIG75_06750 ENOG4105EU9 CIG75_06755 ENOG4105CYC Transferase CIG75_06770 ENOG4105BZU Histidine kinase CIG75_06785 ENOG4105C3R Methionine synthase CIG75_06790 ENOG4108YTE sporulation protein YunB CIG75_06800 ENOG41083MR nifu domain-containing protein CIG75_06805 ENOG4105K63 Thioredoxin CIG75_06810 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CIG75_06835 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) CIG75_06840 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CIG75_06845 ENOG4105D4P Coproporphyrinogen iii oxidase CIG75_06860 ENOG4105CUT histidyl-tRNA synthetase CIG75_06865 ENOG4105C9M aspartyl-trna synthetase CIG75_06875 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CIG75_06905 ENOG4105C3J Cysteine desulfurase CIG75_06930 ENOG4105D3R alkyl hydroperoxide reductase CIG75_06935 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CIG75_06960 ENOG4105VBH UPF0297 protein CIG75_06965 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CIG75_06970 ENOG41085AS UPF0473 protein CIG75_06980 ENOG4105HHA aminodeoxychorismate lyase CIG75_06985 ENOG4108VQJ O-methyltransferase CIG75_06990 ENOG4105DBI uridine monophosphokinase CIG75_06995 ENOG4107XRG penicillin-binding protein CIG75_07000 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_07030 ENOG4105K4H Nlp p60 protein CIG75_07035 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CIG75_07040 ENOG4105CQW ribosome biogenesis GTPase YqeH CIG75_07050 ENOG4105E2X shikimate dehydrogenase CIG75_07055 ENOG410812S Rna-binding protein CIG75_07065 ENOG4108WF2 Metal Dependent Phosphohydrolase CIG75_07075 ENOG4105DXX methyltransferase CIG75_07080 ENOG4105VRS hydrolase family 18 CIG75_07085 ENOG4105C8T Leucyl-tRNA synthetase CIG75_07095 ENOG4105CPF Cell wall formation (By similarity) CIG75_07100 ENOG4105KST dependent repressor CIG75_07105 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CIG75_07110 ENOG4105KQC Competence protein CIG75_07140 ENOG410904A RNA polymerase CIG75_07160 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CIG75_07165 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CIG75_07170 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CIG75_07190 ENOG4105CHU acetyl-coa acetyltransferase CIG75_07220 ENOG4105C26 Dehydrogenase CIG75_07230 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CIG75_07235 ENOG4105C1Q protoporphyrinogen oxidase CIG75_07240 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CIG75_07245 ENOG4108QY0 Membrane CIG75_07250 ENOG4105K4T epimerase CIG75_07325 ENOG4105CKI cobalamin synthesis protein CIG75_07340 ENOG4107ZE5 PPIases accelerate the folding of proteins CIG75_07345 ENOG4108SHJ s-layer protein CIG75_07365 ENOG4105C28 cystathionine CIG75_07375 ENOG4105BZ1 (ABC) transporter CIG75_07395 ENOG4108JPW Aminotransferase CIG75_07400 ENOG4105I3N Conserved Protein CIG75_07420 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CIG75_07430 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CIG75_07440 ENOG4105E39 Enoyl-CoA hydratase CIG75_07445 ENOG4105CEY Amp-dependent synthetase and ligase CIG75_07455 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CIG75_07465 ENOG4105F0N pyrophosphate phospho-hydrolase CIG75_07475 ENOG4105D7N magnesium and cobalt transport protein CorA CIG75_07480 ENOG41069HH 4-oxalocrotonate tautomerase CIG75_07495 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CIG75_07525 ENOG4105BZ1 (ABC) transporter CIG75_07530 ENOG4105BZ1 (ABC) transporter CIG75_07535 ENOG4105VC4 domain protein CIG75_07545 ENOG4105UPD Calcium Proton CIG75_07550 ENOG4105E4C Lytic transglycosylase catalytic CIG75_07560 ENOG4105DFD Na H antiporter CIG75_07565 ENOG4105G5W regulator Fur family CIG75_07580 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CIG75_07585 ENOG4105C7B Threonine dehydratase CIG75_07590 ENOG4105CIH Imidazole acetol-phosphate transaminase CIG75_07595 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CIG75_07615 ENOG4105WH1 Two component transcriptional regulator luxr family CIG75_07645 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i CIG75_07650 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CIG75_07655 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CIG75_07660 ENOG4105DGU Histone deacetylase CIG75_07665 ENOG4105W87 Cbs domain CIG75_07670 ENOG4105F1V Acetoin utilization protein CIG75_07695 ENOG4105C8Y Acetylornithine aminotransferase CIG75_07710 ENOG4105K63 Thioredoxin CIG75_07715 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CIG75_07730 ENOG4105DWV Homoserine O-trans-acetylase CIG75_07735 ENOG4105D6E homoserine dehydrogenase CIG75_07740 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CIG75_07750 ENOG4105E33 succinate dehydrogenase CIG75_07755 ENOG4108W5Z CheC domain protein CIG75_07760 ENOG4105PFC Transcriptional regulator CIG75_07790 ENOG41067TZ transcriptional regulator, MarR family CIG75_07805 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CIG75_07810 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CIG75_07835 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CIG75_07840 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CIG75_07845 ENOG4108IUQ atp-dependent protease CIG75_07855 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CIG75_07870 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CIG75_07880 ENOG4105D2X ABC transporter substrate-binding protein CIG75_07885 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CIG75_07895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CIG75_07900 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CIG75_07910 ENOG4105D52 delta-aminolevulinic acid dehydratase CIG75_07915 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CIG75_07935 ENOG4108YBP pseudouridine synthase CIG75_07960 ENOG4108KS4 Spore coat protein CIG75_07965 ENOG4108TJN glycosyl transferase group 1 CIG75_07970 ENOG41068KH stage VI sporulation protein D CIG75_07985 ENOG4105CUV Homoserine Kinase CIG75_07995 ENOG4107SN7 NLP P60 protein CIG75_08000 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CIG75_08010 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CIG75_08020 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CIG75_08030 ENOG4105CZX twitching motility protein CIG75_08035 ENOG4106A3R peptidase CIG75_08040 ENOG41069ER domain protein CIG75_08055 ENOG4108IJ0 Aspartate ammonia-lyase CIG75_08060 ENOG4108Z03 MAF-like protein CIG75_08065 ENOG4105W5Q DNA repair protein (RadC CIG75_08070 ENOG4105DFF Rod shape-determining protein mreb CIG75_08075 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CIG75_08085 ENOG4107RF6 penicillin-binding protein CIG75_08090 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CIG75_08095 ENOG4107QMS site-determining protein CIG75_08110 ENOG4105C03 ribonuclease CIG75_08115 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CIG75_08125 ENOG4105K46 50S ribosomal protein l27 CIG75_08135 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CIG75_08160 ENOG4107RGJ metallophosphoesterase CIG75_08165 ENOG4107QHF type ii secretion system protein e CIG75_08170 ENOG4105D7Q type ii secretion system CIG75_08210 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CIG75_08215 ENOG4105CAQ asparagine synthetase CIG75_08220 ENOG41090I5 UPF0735 ACT domain-containing protein CIG75_08225 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CIG75_08250 ENOG4105C0D helicase CIG75_08255 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CIG75_08260 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CIG75_08265 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CIG75_08275 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CIG75_08280 ENOG4105DC7 peptidase M24 CIG75_08285 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CIG75_08300 ENOG4105EU0 Major facilitator Superfamily CIG75_08305 ENOG4108ZJ4 polysaccharide deacetylase CIG75_08315 ENOG4108UZ3 Transporter CIG75_08340 ENOG4105D06 uba thif-type nad fad binding protein CIG75_08345 ENOG4108ZAF Molybdopterin CIG75_08350 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CIG75_08355 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CIG75_08360 ENOG4108RIR Molybdenum cofactor biosynthesis protein CIG75_08375 ENOG4105C3Q Glycosyl transferase, family 2 CIG75_08385 ENOG4105VRS hydrolase family 18 CIG75_08400 ENOG4108JUB Transcriptional regulator CIG75_08405 ENOG4107RDP Dehydrogenase CIG75_08420 ENOG4105CPP Dehydrogenase, E1 component CIG75_08425 ENOG4105C7S Dehydrogenase CIG75_08430 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CIG75_08435 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CIG75_08450 ENOG4105C31 Tryptophanyl-tRNA synthetase CIG75_08455 ENOG4105D5P Methylmalonyl-coA mutase CIG75_08460 ENOG4105D5P Methylmalonyl-coA mutase CIG75_08465 ENOG4108ZVT methylmalonyl-coA epimerase CIG75_08470 ENOG4108HNZ carboxyl transferase CIG75_08480 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CIG75_08485 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_08500 ENOG4108Z7R Chaperone CsaA CIG75_08520 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CIG75_08535 ENOG4108YZ4 nudix hydrolase CIG75_08545 ENOG4105MZ9 stage II sporulation protein m CIG75_08555 ENOG4105I3K Ferric uptake regulator, Fur family CIG75_08560 ENOG4105DCF alanine dehydrogenase CIG75_08570 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CIG75_08575 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CIG75_08590 ENOG4105DZ1 carboxypeptidase CIG75_08595 ENOG4105C9U ATP-dependent DNA helicase RecQ CIG75_08615 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_08620 ENOG4105C59 p-type ATPase CIG75_08685 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CIG75_08690 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CIG75_08695 ENOG41082AN stage II sporulation protein CIG75_08700 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CIG75_08705 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_08710 ENOG41090VF Stage v sporulation protein ac CIG75_08715 ENOG4105CZ3 stage V sporulation protein ad CIG75_08725 ENOG4105G6R Stage v sporulation protein ae CIG75_08745 ENOG4107RZC phospholipase d CIG75_08750 ENOG4105DZ1 carboxypeptidase CIG75_08755 ENOG4105CZN Potassium uptake protein CIG75_08760 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CIG75_08765 ENOG4108R6K riboflavin synthase, subunit alpha CIG75_08770 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CIG75_08775 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CIG75_08785 ENOG4105C0R drug resistance transporter emrb qaca subfamily CIG75_08790 ENOG4108Z4T Peptidase M50 CIG75_08795 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CIG75_08800 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CIG75_08810 ENOG4105KBJ sporulation protein ytfj CIG75_08815 ENOG4105DZ1 carboxypeptidase CIG75_08820 ENOG4108JIC nucleoside recognition domain protein CIG75_08835 ENOG4105FE9 pseudouridine synthase CIG75_08845 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CIG75_08850 ENOG4107TWT Cytochrome c biogenesis protein CIG75_08855 ENOG4105CRE cytochrome C CIG75_08860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CIG75_08865 ENOG4105BZU Histidine kinase CIG75_08875 ENOG4105K4P CoA-binding domain protein CIG75_08885 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CIG75_08890 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CIG75_08895 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CIG75_08900 ENOG4107RVV histidinol phosphate phosphatase, hisj family CIG75_08915 ENOG4105C5X domain protein CIG75_08925 ENOG4105S2F CIG75_08930 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CIG75_08935 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CIG75_08940 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CIG75_08960 ENOG4105D03 DNA-3-methyladenine glycosylase II CIG75_08995 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CIG75_09010 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CIG75_09035 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CIG75_09045 ENOG4105C0H protease CIG75_09050 ENOG4105D1U peptidase U62 modulator of DNA gyrase CIG75_09060 ENOG410605W Major Facilitator CIG75_09075 ENOG4105CSM endonuclease III CIG75_09095 ENOG4105C6T cysteine synthase CIG75_09100 ENOG41085GJ domain protein CIG75_09105 ENOG4108IXY short-chain dehydrogenase reductase CIG75_09115 ENOG4105VEQ Cold shock protein CIG75_09130 ENOG4105BZ4 penicillin-binding protein CIG75_09135 ENOG4105EUJ GTP cyclohydrolase i CIG75_09140 ENOG4105EA8 2-Nitropropane dioxygenase CIG75_09150 ENOG4107ZXI Rhomboid family CIG75_09155 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_09165 ENOG410906U SprT-like CIG75_09180 ENOG4105ENA helicase CIG75_09215 ENOG4105C6Y Udp-glucose 6-dehydrogenase CIG75_09220 ENOG4107V9E glucose-1-phosphate thymidylyltransferase CIG75_09225 ENOG4108IAJ Nad-dependent epimerase dehydratase CIG75_09230 ENOG4107SBE Glycosyl transferase (Group 1 CIG75_09235 ENOG4108KS4 Spore coat protein CIG75_09260 ENOG4105ETE Transcriptional regulator (LacI family CIG75_09265 ENOG4105C5I Dehydrogenase CIG75_09270 ENOG4107QSE Dipeptidase CIG75_09275 ENOG4108S6Z Negative regulator of genetic competence CIG75_09280 ENOG4108VMM UPF0756 membrane protein CIG75_09290 ENOG4107RCC Major Facilitator Superfamily CIG75_09295 ENOG4105C28 cystathionine CIG75_09300 ENOG4105C28 cystathionine CIG75_09325 ENOG4105MSI germination protein ypeb CIG75_09330 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CIG75_09345 ENOG4105CAT Cytidine monophosphate kinase CIG75_09360 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CIG75_09370 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CIG75_09380 ENOG4105S2F CIG75_09385 ENOG41065D1 CIG75_09400 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CIG75_09405 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CIG75_09410 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CIG75_09415 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CIG75_09420 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CIG75_09425 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CIG75_09435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CIG75_09455 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CIG75_09570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CIG75_09590 ENOG4105MUA Resistance protein CIG75_09595 ENOG4108ZJ4 polysaccharide deacetylase CIG75_09600 ENOG41080UX Methyltransferase CIG75_09605 ENOG4105CH6 catalase CIG75_09615 ENOG4105WG9 Conserved Protein CIG75_09635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CIG75_09640 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CIG75_09645 ENOG4105DVY radical SAM domain protein CIG75_09655 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) CIG75_09665 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CIG75_09675 ENOG4105BZU Histidine kinase CIG75_09685 ENOG4105BZU Histidine kinase CIG75_09725 ENOG4105CPK Glycosyl transferase (Group 1 CIG75_09735 ENOG4105C34 Pseudouridine synthase CIG75_09745 ENOG4108XET gCN5-related N-acetyltransferase CIG75_09750 ENOG4105HMI Membrane CIG75_09765 ENOG4105KAC Antibiotic biosynthesis monooxygenase CIG75_09780 ENOG41085GJ domain protein CIG75_09810 ENOG4108YM7 Gcn5-related n-acetyltransferase CIG75_09825 ENOG4107YZX Universal stress protein CIG75_09830 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CIG75_09835 ENOG4108IEG Formate dehydrogenase Alpha subunit CIG75_09855 ENOG4105DTI Phosphonopyruvate decarboxylase CIG75_09860 ENOG4105CAS nag kinase CIG75_09865 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CIG75_09870 ENOG4105E2X shikimate dehydrogenase CIG75_09885 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CIG75_09895 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CIG75_09900 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CIG75_09920 ENOG4105DVT helicase CIG75_09925 ENOG4105QIV RNA polymerase CIG75_09930 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CIG75_09935 ENOG4105FDF Could be involved in DNA repair (By similarity) CIG75_09940 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) CIG75_09945 ENOG4105DQE DNA ligase CIG75_09950 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CIG75_09955 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CIG75_09960 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CIG75_09965 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CIG75_09975 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CIG75_09990 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CIG75_10000 ENOG4105C5S asparaginyl-tRNA synthetase CIG75_10015 ENOG4105C5H ABC transporter CIG75_10035 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CIG75_10045 ENOG4107YBY Hydrolase CIG75_10050 ENOG4105DA5 (ABC) transporter CIG75_10065 ENOG4105EMN RNA polymerase sigma factor CIG75_10075 ENOG4108IJ6 ABC transporter CIG75_10080 ENOG4105CXI aluminum resistance protein CIG75_10085 ENOG4105KV4 Transcriptional regulator CIG75_10090 ENOG4105C5F glutamine synthetase CIG75_10095 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CIG75_10100 ENOG4105CHR reductase CIG75_10105 ENOG4105CEY Amp-dependent synthetase and ligase CIG75_10115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CIG75_10130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CIG75_10140 ENOG4105C0Z ABC transporter CIG75_10145 ENOG4108IV0 ABC, transporter CIG75_10150 ENOG4105C32 Amino acid ABC transporter (Permease) CIG75_10155 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CIG75_10180 ENOG4105JFG SpoIID LytB domain protein CIG75_10190 ENOG4105FDP GntR family transcriptional regulator CIG75_10195 ENOG4105RD7 BadF BadG BcrA BcrD CIG75_10200 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CIG75_10205 ENOG4105D17 glycoside hydrolase, family 3 domain protein CIG75_10210 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CIG75_10215 ENOG4105EHZ conserved protein UCP016719 CIG75_10220 ENOG4105BZ7 extracellular solute-binding protein family 1 CIG75_10225 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CIG75_10230 ENOG4105DRS transport system, permease CIG75_10235 ENOG4107S1E Beta-lactamase CIG75_10240 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CIG75_10245 ENOG4105CE4 GlcNAc 6-P deacetylase CIG75_10260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CIG75_10265 ENOG4105DFU Cell wall formation (By similarity) CIG75_10295 ENOG4105CRN Aminoglycoside phosphotransferase CIG75_10300 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CIG75_10395 ENOG4107T8T UPF0173 metal-dependent hydrolase CIG75_10400 ENOG4105BZU Histidine kinase CIG75_10420 ENOG4108903 Formimidoylglutamase CIG75_10425 ENOG4105CI2 imidazolone-5-propionate hydrolase CIG75_10435 ENOG4105C84 Histidine ammonia-lyase CIG75_10450 ENOG4107SJI Dehydrogenase CIG75_10455 ENOG4105BZ8 glutamate synthase CIG75_10535 ENOG4105C0W non-ribosomal peptide synthetase CIG75_10550 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CIG75_10555 ENOG4105BZ1 (ABC) transporter CIG75_10560 ENOG4106F1P AAA ATPase, central domain protein CIG75_10600 ENOG4106F1P AAA ATPase, central domain protein CIG75_10660 ENOG4105EA8 2-Nitropropane dioxygenase CIG75_10670 ENOG4105C0R drug resistance transporter emrb qaca subfamily CIG75_10680 ENOG4108NVR Methyl-accepting chemotaxis CIG75_10720 ENOG4107XZC Restriction modification system DNA (Specificity CIG75_10730 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CIG75_10735 ENOG41067SE Tetr family transcriptional regulator CIG75_10740 ENOG4105EYF MMPL domain protein CIG75_10825 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CIG75_10830 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CIG75_10835 ENOG4107YX5 Pfam:DUF548 CIG75_10840 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CIG75_10845 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CIG75_10855 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CIG75_10865 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CIG75_10875 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CIG75_10885 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CIG75_10890 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CIG75_10895 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CIG75_10900 ENOG4105DK0 Indole-3-glycerol phosphate synthase CIG75_10905 ENOG4108I0Q anthranilate phosphoribosyltransferase CIG75_10910 ENOG4105KHN chorismate mutase CIG75_10915 ENOG4105D49 3-dehydroquinate synthase CIG75_10920 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CIG75_10925 ENOG4105CN9 Peptidase m42 family protein CIG75_10930 ENOG4105CN9 Peptidase m42 family protein CIG75_10935 ENOG4105CN9 Peptidase m42 family protein CIG75_11090 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CIG75_11160 ENOG4105EB3 Histidine kinase CIG75_11270 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) CIG75_11275 ENOG4108I5D sulfate abc transporter CIG75_11285 ENOG4108IJ6 ABC transporter CIG75_11300 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CIG75_11320 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CIG75_11340 ENOG4105EWK phytoene CIG75_11350 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CIG75_11355 ENOG4108Z5K methylglyoxal synthase CIG75_11360 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CIG75_11365 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CIG75_11370 ENOG4105H20 Sporulation integral membrane protein YlbJ CIG75_11375 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CIG75_11380 ENOG4108K88 Membrane CIG75_11385 ENOG4107ZTW SNARE associated Golgi CIG75_11395 ENOG4108JYZ YitT family CIG75_11415 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CIG75_11420 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CIG75_11440 ENOG4105CFI type iii restriction protein res subunit CIG75_11465 ENOG4105DJ4 phosphatidylserine decarboxylase CIG75_11470 ENOG4105JAB phenazine biosynthesis protein, phzf family CIG75_11475 ENOG410839P CIG75_11480 ENOG410839P CIG75_11505 ENOG4105CKI cobalamin synthesis protein CIG75_11515 ENOG4107V2S Transcriptional regulator CIG75_11520 ENOG4105DVH amino acid CIG75_11545 ENOG4105DB7 PHP domain protein CIG75_11550 ENOG4108IGT Dipeptidase CIG75_11555 ENOG4105MCT stage V sporulation protein S CIG75_11560 ENOG4105D48 metallophosphoesterase CIG75_11570 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CIG75_11590 ENOG4105CEV competence damage-inducible protein CIG75_11595 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CIG75_11600 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) CIG75_11605 ENOG4108VPT UPF0234 protein CIG75_11665 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CIG75_11675 ENOG4105UIB (ABC) transporter CIG75_11680 ENOG4108JQ9 ABC transporter CIG75_11685 ENOG4105DIH basic membrane CIG75_11690 ENOG4105FDP GntR family transcriptional regulator CIG75_11695 ENOG4105CNU cell division protein FtsK CIG75_11705 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CIG75_11710 ENOG4105CN5 Metallo-Beta-Lactamase CIG75_11715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CIG75_11725 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CIG75_11730 ENOG4108S0H Dipicolinic acid synthetase, b subunit CIG75_11735 ENOG4105E35 Dipicolinate synthase subunit A CIG75_11745 ENOG4105C1V Peptidase, M16 CIG75_11760 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CIG75_11765 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CIG75_11780 ENOG4105DTN riboflavin biosynthesis protein ribF CIG75_11785 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CIG75_11790 ENOG4105SFS phosphoesterase RecJ domain protein CIG75_11800 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CIG75_11815 ENOG4105CHV Transcription elongation factor NusA CIG75_11820 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CIG75_11825 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CIG75_11830 ENOG4105CKK Glycosyl transferase, family 2 CIG75_11835 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CIG75_11845 ENOG4105CUB amino acid CIG75_11850 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CIG75_11855 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CIG75_11870 ENOG4105KNE Phosphatidate cytidylyltransferase CIG75_11875 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CIG75_11880 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CIG75_11885 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CIG75_11890 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CIG75_11895 ENOG4105CE9 30S ribosomal protein S2 CIG75_11920 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_11930 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) CIG75_11940 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CIG75_11945 ENOG4105CBS Chea signal transduction histidine kinase CIG75_11950 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CIG75_11960 ENOG4105FZW flagellar biosynthesis regulator FlhF CIG75_11965 ENOG4105D7B Flagellar biosynthesis protein flha CIG75_11970 ENOG4105D00 flagellar biosynthetic protein flhB CIG75_11975 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CIG75_11980 ENOG4105VS8 Flagellar biosynthetic protein fliq CIG75_11985 ENOG4105CN7 Flagellar biosynthetic protein FliP CIG75_11995 ENOG4107YTP response regulator receiver protein CIG75_12000 ENOG4105DD5 Flagellar motor switch protein CIG75_12005 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CIG75_12020 ENOG4108JQA flagellar CIG75_12030 ENOG410822I Flagellar hook capping protein CIG75_12055 ENOG4105W2B Flagellar assembly protein CIG75_12060 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CIG75_12065 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CIG75_12075 ENOG4108ZC9 flagellar basal-body rod protein flgc CIG75_12080 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CIG75_12085 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) CIG75_12090 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CIG75_12095 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CIG75_12100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CIG75_12105 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CIG75_12110 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CIG75_12115 ENOG4105C79 DNA protecting protein DprA CIG75_12120 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CIG75_12145 ENOG4105C6X Major Facilitator CIG75_12195 ENOG4105VFF UPF0102 protein CIG75_12200 ENOG4105VM1 flagellar CIG75_12210 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CIG75_12215 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CIG75_12225 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CIG75_12230 ENOG41068JE domain protein CIG75_12235 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CIG75_12240 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CIG75_12295 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CIG75_12310 ENOG4105VB6 UPF0109 protein CIG75_12315 ENOG4105K5M 30s ribosomal protein S16 CIG75_12325 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CIG75_12330 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CIG75_12335 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CIG75_12345 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CIG75_12350 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CIG75_12355 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CIG75_12360 ENOG4105CHR reductase CIG75_12365 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CIG75_12375 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CIG75_12380 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CIG75_12385 ENOG41067VY 50S ribosomal protein L32 CIG75_12395 ENOG4105CDE UPF0348 protein CIG75_12400 ENOG41063PX domain protein CIG75_12405 ENOG4105D78 K07001 NTE family protein CIG75_12410 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CIG75_12415 ENOG4106H78 methyltransferase CIG75_12425 ENOG4108SHJ s-layer protein CIG75_12440 ENOG4105CB5 ATP-dependent DNA helicase recG CIG75_12445 ENOG4105EJQ L-serine dehydratase CIG75_12455 ENOG4105DP4 dak2 domain fusion protein ylov CIG75_12460 ENOG4108ZAA Alkaline-shock protein CIG75_12465 ENOG4105VB9 50S ribosomal protein l28 CIG75_12475 ENOG4105DJV ribulose-phosphate 3-epimerase CIG75_12480 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CIG75_12485 ENOG4105D9P serine threonine protein kinase CIG75_12490 ENOG4108ZF3 Phosphatase CIG75_12495 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CIG75_12500 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CIG75_12505 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CIG75_12510 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CIG75_12515 ENOG4105C25 Primosomal protein n' CIG75_12520 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CIG75_12525 ENOG41084KE Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CIG75_12535 ENOG4105KC4 UPF0296 protein CIG75_12540 ENOG4105DSJ YicC domain protein CIG75_12545 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CIG75_12565 ENOG4105F23 Fibronectin-binding protein CIG75_12570 ENOG4105CJ1 ABC, transporter CIG75_12585 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CIG75_12590 ENOG410839P CIG75_12620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CIG75_12625 ENOG4105CQB FAD linked oxidase domain protein CIG75_12630 ENOG4105E8V Alpha Beta Hydrolase Fold protein CIG75_12880 ENOG4105QBX endodeoxyribonuclease RusA CIG75_12900 ENOG4105CDU Replicative dna helicase CIG75_12905 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CIG75_12915 ENOG4105C4R Atp-dependent dna helicase CIG75_12975 ENOG4108IMY Transcriptional regulator CIG75_13005 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CIG75_13010 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CIG75_13015 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CIG75_13020 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CIG75_13025 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CIG75_13035 ENOG4105CD3 dihydroorotase CIG75_13040 ENOG4105CXT aspartate transcarbamylase CIG75_13050 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CIG75_13055 ENOG4105C34 Pseudouridine synthase CIG75_13060 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CIG75_13065 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CIG75_13190 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CIG75_13195 ENOG4105DFA alanine racemase domain protein CIG75_13205 ENOG4105WR5 sporulation protein, YlmC YmxH family CIG75_13215 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_13220 ENOG4108AWX Sporulation factor SpoIIGA CIG75_13240 ENOG4105DQ6 Transposase CIG75_13265 ENOG4105W5Z CIG75_13270 ENOG4107YHX fad dependent oxidoreductase CIG75_13290 ENOG4105C0R drug resistance transporter emrb qaca subfamily CIG75_13295 ENOG4105WQT MbtH domain protein CIG75_13300 ENOG4105CEY Amp-dependent synthetase and ligase CIG75_13305 ENOG4105WQI isochorismatase CIG75_13310 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CIG75_13315 ENOG4105E4F Isochorismate synthase CIG75_13320 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CIG75_13450 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CIG75_13455 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CIG75_13460 ENOG4105K67 small basic protein CIG75_13480 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CIG75_13485 ENOG4105D4A Cell wall formation (By similarity) CIG75_13490 ENOG4105CNI cell division protein FtsW CIG75_13495 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CIG75_13500 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CIG75_13505 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CIG75_13510 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CIG75_13515 ENOG4105CJN penicillin-binding protein CIG75_13520 ENOG4105CJN penicillin-binding protein CIG75_13530 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CIG75_13535 ENOG4108V6E Cell division protein mraZ CIG75_13540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CIG75_13545 ENOG4105KVH Transcriptional regulator CIG75_13560 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CIG75_13565 ENOG4108J59 Extracellular solute-binding protein, family 5 CIG75_13570 ENOG4107QX3 carboxylase CIG75_13575 ENOG4105E39 Enoyl-CoA hydratase CIG75_13580 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CIG75_13585 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CIG75_13590 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CIG75_13605 ENOG4105CHR reductase CIG75_13610 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CIG75_13615 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CIG75_13635 ENOG4105CI3 gtp-binding protein typa CIG75_13640 ENOG4105E0C molybdate abc transporter CIG75_13645 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CIG75_13650 ENOG4105C5H ABC transporter CIG75_13655 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CIG75_13670 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase CIG75_13675 ENOG4105C10 Electron transfer flavoprotein CIG75_13680 ENOG4105BZJ Electron transfer flavoprotein CIG75_13710 ENOG4105BZU Histidine kinase CIG75_13760 ENOG4105C5H ABC transporter CIG75_13830 ENOG4105S1Z Stage IV sporulation protein B CIG75_13835 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CIG75_13840 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CIG75_13845 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CIG75_13850 ENOG4105DX0 Hemolysin A CIG75_13855 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CIG75_13870 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CIG75_13880 ENOG4105CAY ferredoxin--nadp reductase CIG75_13885 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CIG75_13890 ENOG4105M7K Involved in the transcription termination process (By similarity) CIG75_13905 ENOG4108ZSR alkaline shock protein CIG75_13910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CIG75_13930 ENOG410644B Stage III sporulation protein af CIG75_13940 ENOG4105KQ4 Stage iii sporulation protein ad CIG75_13955 ENOG4105CD2 stage iii sporulation protein aa CIG75_13960 ENOG4107XJU UPF0178 protein CIG75_13985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CIG75_14005 ENOG4105M6F mutator MutT protein CIG75_14020 ENOG4105D9P serine threonine protein kinase CIG75_14030 ENOG4108YG3 N-acetyltransferase CIG75_14035 ENOG4105VPS UPF0291 protein CIG75_14040 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CIG75_14055 ENOG4105EPR degv family CIG75_14065 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CIG75_14070 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) CIG75_14115 ENOG4105CBX hi0933 family CIG75_14120 ENOG4105F22 Major Facilitator Superfamily CIG75_14125 ENOG4105F1K Glutamine amidotransferase CIG75_14145 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CIG75_14150 ENOG4105CRQ synthase (Component I) CIG75_14155 ENOG4105DDQ anthranilate synthase CIG75_14160 ENOG4107XM9 (LipO)protein CIG75_14190 ENOG4107QJE Chromosome Partitioning Protein CIG75_14230 ENOG4106YBV Methyl-accepting chemotaxis CIG75_14240 ENOG4105CYC Transferase CIG75_14245 ENOG4105DY9 regulatoR CIG75_14255 ENOG4105KT7 mgtC SapB transporter CIG75_14265 ENOG4105BZ1 (ABC) transporter CIG75_14285 ENOG4107FS9 Membrane CIG75_14310 ENOG4106P55 Transcriptional regulator CIG75_14330 ENOG4105KBH arsR family transcriptional regulator CIG75_14340 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CIG75_14345 ENOG4108ZJ4 polysaccharide deacetylase CIG75_14365 ENOG4105E1K spore germination protein CIG75_14370 ENOG4108B31 Spore germination protein CIG75_14415 ENOG4105D6N CoA-transferase, subunit a CIG75_14485 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CIG75_14490 ENOG4105DDQ anthranilate synthase CIG75_14495 ENOG4105CRQ synthase (Component I) CIG75_14500 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CIG75_14510 ENOG4105CFP Peptidase U32 CIG75_14515 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CIG75_14520 ENOG41090WU lipolytic protein G-D-S-L family CIG75_14525 ENOG4105CJ1 ABC, transporter CIG75_14530 ENOG4108TU7 Inherit from COG: (ABC) transporter CIG75_14535 ENOG410667J hydrolase CIG75_14540 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CIG75_14550 ENOG4105CND Glycosyl transferase, family 2 CIG75_14555 ENOG4105DZ6 Band 7 protein CIG75_14570 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CIG75_14575 ENOG4107G87 m6 family metalloprotease domain protein CIG75_14590 ENOG4105CAQ asparagine synthetase CIG75_14605 ENOG4105DQ6 Transposase CIG75_14615 ENOG4108UT2 hemolysin iii CIG75_14630 ENOG4105EGD dinuclear metal center protein, YbgI family CIG75_14640 ENOG4105C1G acyl-Coa dehydrogenase CIG75_14650 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_14655 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CIG75_14660 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CIG75_14665 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CIG75_14685 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CIG75_14700 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) CIG75_14710 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CIG75_14720 ENOG41080IJ Diacylglycerol kinase CIG75_14725 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CIG75_14730 ENOG4105CTJ Metal Dependent Phosphohydrolase CIG75_14735 ENOG4105C9A Phoh family CIG75_14745 ENOG41068P3 sporulation protein YqfC CIG75_14755 ENOG4105DI5 UPF0365 protein CIG75_14760 ENOG4105F7J membrane-bound serine protease CIG75_14765 ENOG4105KTH gatB Yqey CIG75_14770 ENOG4105VCC 30S ribosomal protein S21 CIG75_14785 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CIG75_14790 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CIG75_14795 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CIG75_14800 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CIG75_14810 ENOG4105CFG Acts as a chaperone (By similarity) CIG75_14820 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CIG75_14825 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CIG75_14840 ENOG4105CSA Coproporphyrinogen iii oxidase CIG75_14850 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CIG75_14870 ENOG4108ZRV stage ii sporulation protein p CIG75_14885 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CIG75_14895 ENOG4105TQK DNA polymerase iii, delta' subunit CIG75_14900 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CIG75_14910 ENOG4105E5J UV damage endonuclease CIG75_14915 ENOG4105PGM cation diffusion facilitator family transporter CIG75_14920 ENOG41082BM Transcriptional regulator, arsr family CIG75_14935 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CIG75_14950 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CIG75_14955 ENOG4105D4U had-superfamily hydrolase, subfamily iia CIG75_14960 ENOG4108WBT adenosyltransferase CIG75_14965 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CIG75_15085 ENOG4105DQU oxidoreductase, subunit beta CIG75_15090 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CIG75_15095 ENOG4105C28 cystathionine CIG75_15100 ENOG41069ER domain protein CIG75_15120 ENOG4105CJ1 ABC, transporter CIG75_15150 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CIG75_15155 ENOG41080HI glycine oxidase CIG75_15165 ENOG4105C1J atp-dependent rna helicase CIG75_15185 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CIG75_15190 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CIG75_15195 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CIG75_15200 ENOG4105DQU oxidoreductase, subunit beta CIG75_15220 ENOG4105C3M thioredoxin reductase CIG75_15225 ENOG4106210 phosphatase activity CIG75_15235 ENOG4108HK0 -acetyltransferase CIG75_15265 ENOG4105CN9 Peptidase m42 family protein CIG75_15280 ENOG4105KZD Domain of unknown function (DUF1805) CIG75_15295 ENOG4107T5V SNARE associated Golgi CIG75_15300 ENOG4105DP8 Major facilitator superfamily MFS_1 CIG75_15320 ENOG4105D5T phosphonate abc transporter CIG75_15330 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_15335 ENOG410667J hydrolase CIG75_15340 ENOG4105DCI Phosphohydrolase CIG75_15350 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CIG75_15355 ENOG4108REF Sporulation integral membrane protein ytvi CIG75_15360 ENOG4108REF Sporulation integral membrane protein ytvi CIG75_15370 ENOG4105E5W Transporter CIG75_15375 ENOG4105DUM transcriptional regulator, lysR family CIG75_15390 ENOG4105DQU oxidoreductase, subunit beta CIG75_15395 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CIG75_15405 ENOG4107QPH glycogen) synthase CIG75_15410 ENOG41069ER domain protein CIG75_15415 ENOG4105CXN decarboxylase CIG75_15420 ENOG4108XFG YwhD family CIG75_15435 ENOG4105C6X Major Facilitator CIG75_15440 ENOG4105CDA abc transporter atp-binding protein CIG75_15445 ENOG4105E5Q amino acid AbC transporter CIG75_15450 ENOG4108HW3 (ABC) transporter CIG75_15460 ENOG4105E0M Sulfatase CIG75_15465 ENOG4108IPJ Membrane CIG75_15475 ENOG41080E8 Transcriptional regulator, Spx MgsR family CIG75_15480 ENOG4105K4P CoA-binding domain protein CIG75_15500 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CIG75_15505 ENOG4105DC7 peptidase M24 CIG75_15515 ENOG41069FQ Metallo-beta-lactamase superfamily CIG75_15550 ENOG4105DPN Oligoendopeptidase f CIG75_15565 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CIG75_15570 ENOG4105K4H Nlp p60 protein CIG75_15605 ENOG4105WEF catalase CIG75_15615 ENOG4105K63 Thioredoxin CIG75_15620 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CIG75_15650 ENOG4105C0F tryptophanase EC 4.1.99.1 CIG75_15655 ENOG4108JUB Transcriptional regulator CIG75_15665 ENOG4108X4Q Hydrolase CIG75_15670 ENOG4105BZU Histidine kinase CIG75_15695 ENOG4105EFZ amidohydrolase CIG75_15700 ENOG4108S4H thioesterase Superfamily protein CIG75_15715 ENOG4105EC3 peptidase S51, dipeptidase E CIG75_15735 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_15755 ENOG4105DWT malate dehydrogenase (quinone) CIG75_15765 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CIG75_15770 ENOG4105CR5 Class II aldolase adducin family protein CIG75_15775 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CIG75_15780 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate CIG75_15800 ENOG4107YCR Transcriptional regulator, ARSR family CIG75_15815 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CIG75_15820 ENOG4107QIV Cytochrome c biogenesis protein CIG75_15835 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CIG75_15840 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CIG75_15850 ENOG4107ZTW SNARE associated Golgi CIG75_15865 ENOG4105BZU Histidine kinase CIG75_15870 ENOG4105CNI cell division protein FtsW CIG75_15885 ENOG4107Z36 nucleotidyl transferase CIG75_15905 ENOG4105CUZ uba thif-type nad fad binding protein CIG75_15920 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CIG75_15925 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CIG75_15930 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CIG75_15975 ENOG4105CSA Coproporphyrinogen iii oxidase CIG75_15980 ENOG4105CSA Coproporphyrinogen iii oxidase CIG75_16025 ENOG4105K4I Scp-like extracellular CIG75_16030 ENOG4105DUM transcriptional regulator, lysR family CIG75_16035 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CIG75_16050 ENOG41086CI Bifunctional phosphoglucose phosphomannose isomerase CIG75_16055 ENOG4108Y5D Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CIG75_16065 ENOG4105CPI Metal Dependent Phosphohydrolase CIG75_16080 ENOG4105D5P Methylmalonyl-coA mutase CIG75_16085 ENOG4107Z3H Transcriptional regulator, TetR family CIG75_16115 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CIG75_16120 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CIG75_16140 ENOG4108JJB ABC transporter CIG75_16145 ENOG4105C1G acyl-Coa dehydrogenase CIG75_16150 ENOG4105CHU acetyl-coa acetyltransferase CIG75_16160 ENOG41069ER domain protein CIG75_16180 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CIG75_16200 ENOG41060GV RNA binding s1 domain protein CIG75_16205 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CIG75_16215 ENOG4105BZU Histidine kinase CIG75_16230 ENOG4108J59 Extracellular solute-binding protein, family 5 CIG75_16235 ENOG4107YRI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CIG75_16260 ENOG4105DER m42 family CIG75_16280 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CIG75_16300 ENOG4108KGH TRANSCRIPTIONal CIG75_16305 ENOG4107YU2 histidine triad (hIT) protein CIG75_16315 ENOG4105VV2 CIG75_16360 ENOG4107XWI flavin reductase domain protein, FMN-binding CIG75_16370 ENOG4105ERH Fumarylacetoacetate hydrolase CIG75_16375 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CIG75_16385 ENOG4108YBP pseudouridine synthase CIG75_16400 ENOG4105BZN citrate synthase CIG75_16410 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CIG75_16420 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CIG75_16430 ENOG4105CUT histidyl-tRNA synthetase CIG75_16470 ENOG4105C10 Electron transfer flavoprotein CIG75_16475 ENOG4105BZJ Electron transfer flavoprotein CIG75_16480 ENOG4107Z3H Transcriptional regulator, TetR family CIG75_16495 ENOG4107RWR Sodium hydrogen exchanger CIG75_16510 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_16515 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_16535 ENOG4105C88 aminopeptidase CIG75_16540 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CIG75_16550 ENOG4105NAA Cytochrome C oxidase, subunit II CIG75_16570 ENOG4105N5T Radical SAM Protein CIG75_16575 ENOG4105EWK phytoene CIG75_16580 ENOG4108XG4 DNA-binding transcriptional regulator CIG75_16590 ENOG4105ECY inositol monophosphatase CIG75_16595 ENOG4108HGU Histidine kinase CIG75_16600 ENOG4108W7F transporter, permease CIG75_16605 ENOG4108JJB ABC transporter CIG75_16610 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CIG75_16635 ENOG4105CE1 Ferrous iron transport protein b CIG75_16640 ENOG4105CE1 Ferrous iron transport protein b CIG75_16655 ENOG4105CV8 reductase CIG75_16665 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CIG75_16680 ENOG4105BZ1 (ABC) transporter CIG75_16685 ENOG4105BZ1 (ABC) transporter CIG75_16695 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CIG75_16715 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CIG75_16730 ENOG4105MIR Phenylalanine 4-monooxygenase CIG75_16735 ENOG4107JTW chlorite dismutase CIG75_16745 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CIG75_16750 ENOG4105D9U N-acetyltransferase CIG75_16755 ENOG4105CHM Aminotransferase CIG75_16760 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR CIG75_16765 ENOG41067QW Transcriptional regulator CIG75_16770 ENOG4108S4H thioesterase Superfamily protein CIG75_16790 ENOG4105CIF Ornithine Cyclodeaminase CIG75_16795 ENOG4105DBM Siderophore biosynthesis protein CIG75_16800 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CIG75_16830 ENOG4105CIG ABC transporter CIG75_16835 ENOG4105CIG ABC transporter CIG75_16845 ENOG4108MES Periplasmic binding protein CIG75_16850 ENOG4105DQ5 transport system permease protein CIG75_16855 ENOG4108IHU transport system permease protein CIG75_16860 ENOG4105E0A ABC, transporter CIG75_16865 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CIG75_16870 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CIG75_16880 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CIG75_16885 ENOG4108TGR phosphatase CIG75_16890 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CIG75_16895 ENOG4108YZT Adenosylcobinamide kinase CIG75_16900 ENOG4107QZB decarboxylase CIG75_16905 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CIG75_16910 ENOG4108P62 biosynthesis protein (CbiG) CIG75_16915 ENOG4105CIA precorrin-4 C(11)-methyltransferase CIG75_16925 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase CIG75_16930 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CIG75_16935 ENOG41081F0 Precorrin-8x methylmutase CIG75_16940 ENOG4108JTQ reductase CIG75_16945 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CIG75_16950 ENOG4105E4R Precorrin-3B C17-methyltransferase CIG75_16955 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CIG75_16960 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CIG75_16970 ENOG4108RAV Conserved protein CIG75_16980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CIG75_16990 ENOG4105VEQ Cold shock protein CIG75_16995 ENOG4108Z66 YbaK ebsC protein CIG75_17040 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CIG75_17045 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CIG75_17055 ENOG4105XZU Preprotein translocase, subunit SecG CIG75_17060 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CIG75_17070 ENOG4105CP7 Triose-phosphate isomerase CIG75_17075 ENOG4105BZA Phosphoglycerate kinase CIG75_17090 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CIG75_17105 ENOG4105DWF phosphomethylpyrimidine kinase CIG75_17130 ENOG4105E0M Sulfatase CIG75_17135 ENOG4105E50 uracil-dna glycosylase CIG75_17160 ENOG4105KRI phosphocarrier protein (HPr CIG75_17165 ENOG4105CIE May be required for sporulation (By similarity) CIG75_17170 ENOG4105CHW UPF0052 protein CIG75_17175 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CIG75_17180 ENOG4105C8Q Methyl-accepting chemotaxis CIG75_17185 ENOG4105EM7 Selenocysteine-specific translation elongation factor CIG75_17190 ENOG4105C3M thioredoxin reductase CIG75_17200 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CIG75_17205 ENOG4108RAC Rubrerythrin CIG75_17220 ENOG4108V06 Glutathione peroxidase CIG75_17245 ENOG4105CJ1 ABC, transporter CIG75_17260 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CIG75_17280 ENOG4105WH1 Two component transcriptional regulator luxr family CIG75_17300 ENOG4105D9P serine threonine protein kinase CIG75_17310 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CIG75_17315 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CIG75_17320 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CIG75_17340 ENOG4108S4C acetyltransferase CIG75_17350 ENOG4105HKU nucleoside recognition domain-containing protein CIG75_17355 ENOG4105E4C Lytic transglycosylase catalytic CIG75_17365 ENOG4105CMR udp-glucose 4-epimerase CIG75_17380 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CIG75_17385 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CIG75_17390 ENOG4105ER2 Ompa motb domain protein CIG75_17395 ENOG4105E14 MotA TolQ exbB proton channel CIG75_17410 ENOG4105E4C Lytic transglycosylase catalytic CIG75_17415 ENOG4105CRP Part of the ABC transporter FtsEX involved in CIG75_17420 ENOG4105CAK Cell division ATP-binding protein ftsE CIG75_17430 ENOG4105DIK (ABC) transporter CIG75_17435 ENOG4105DSE periplasmic solute binding protein CIG75_17505 ENOG4105EYF MMPL domain protein CIG75_17530 ENOG4105DQX Zinc finger domain CIG75_17560 ENOG4105D06 uba thif-type nad fad binding protein CIG75_17570 ENOG4107RBB ABC transporter, permease CIG75_17575 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CIG75_17580 ENOG4105DJY efflux transporter, rnd family, mfp subunit CIG75_17590 ENOG4105CH7 arginosuccinase CIG75_17595 ENOG4105CDH Citrulline--aspartate ligase CIG75_17600 ENOG4105DBV ornithine carbamoyltransferase CIG75_17605 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CIG75_17660 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CIG75_17665 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CIG75_17670 ENOG410801F ribosomal-protein-alanine acetyltransferase CIG75_17675 ENOG41072GX Peptidase M22 Glycoprotease CIG75_17680 ENOG4105K8N protein family UPF0079, ATPase CIG75_17685 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CIG75_17690 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CIG75_17705 ENOG4107XMU Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CIG75_17725 ENOG410841Q phosphoesterase PA-phosphatase related protein CIG75_17740 ENOG4107P6T Protein CrcB homolog CIG75_17755 ENOG4108UM1 dedA family CIG75_17780 ENOG4108Z86 Glutamine amidotransferase CIG75_17785 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CIG75_17790 ENOG4105BZU Histidine kinase CIG75_17795 ENOG4107X2U Inherit from COG: Exonuclease-like protein CIG75_17840 ENOG4105DQ6 Transposase CIG75_17865 ENOG4108I5C dEAD DEAH box helicase CIG75_17875 ENOG4105N80 Ferric uptake regulator, Fur family CIG75_17885 ENOG4105WH1 Two component transcriptional regulator luxr family CIG75_17890 ENOG4105ENE Histidine kinase CIG75_17905 ENOG4105E63 Pfam:DUF178 CIG75_17910 ENOG4108UIH futalosine nucleosidase CIG75_17925 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CIG75_17935 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CIG75_17945 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CIG75_17950 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CIG75_17955 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CIG75_17960 ENOG4105KA0 thioesterase Superfamily protein CIG75_17975 ENOG4108TU7 Inherit from COG: (ABC) transporter CIG75_17980 ENOG4105CJ1 ABC, transporter CIG75_17995 ENOG4105CJ1 ABC, transporter CIG75_18015 ENOG4108MUZ hydrolase CIG75_18025 ENOG4108ZCF integral membrane protein CIG75_18035 ENOG4107SDU Methyl-accepting chemotaxis CIG75_18050 ENOG4105CDY transcriptional regulatory protein CIG75_18055 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CIG75_18070 ENOG4105C7S Dehydrogenase CIG75_18095 ENOG4105CHU acetyl-coa acetyltransferase CIG75_18100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CIG75_18105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CIG75_18120 ENOG4108UKI Enoyl-CoA hydratase CIG75_18160 ENOG4108ISG Major Facilitator CIG75_18285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CIG75_18300 ENOG4105DQ6 Transposase CIG75_18365 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CIG75_18370 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CIG75_18385 ENOG4108QG2 Membrane CIG75_18390 ENOG41090VF Stage v sporulation protein ac CIG75_18395 ENOG4105CZ3 stage V sporulation protein ad CIG75_18460 ENOG4107QYV phosphohexose isomerase CIG75_18480 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CIG75_18490 ENOG4105D3Q Sugar transferase CIG75_18495 ENOG4108PQP glycosyl transferase group 1 CIG75_18510 ENOG4107T8Q Glycosyl transferase (Group 1 CIG75_18540 ENOG4105F6J Alpha beta hydrolase fold CIG75_18550 ENOG4105BZU Histidine kinase CIG75_18560 ENOG4105GZI Transcriptional regulator CIG75_18575 ENOG4105EYF MMPL domain protein CIG75_18600 ENOG4107Y80 Major Facilitator superfamily CIG75_18610 ENOG4108ZCF integral membrane protein CIG75_18620 ENOG4105C8Y Acetylornithine aminotransferase CIG75_18640 ENOG4105CIG ABC transporter CIG75_18645 ENOG4107QNG Phosphoribosylglycinamide synthetase CIG75_18650 ENOG4105DC1 bifunctional purine biosynthesis protein purh CIG75_18655 ENOG4108V3E phosphoribosylglycinamide formyltransferase CIG75_18660 ENOG4105CXB phosphoribosylaminoimidazole synthetase CIG75_18670 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CIG75_18675 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CIG75_18680 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CIG75_18685 ENOG4105C8V SAICAR synthetase CIG75_18690 ENOG4105C83 adenylosuccinate lyase CIG75_18695 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CIG75_18710 ENOG4105C7N Xanthine uracil vitamin C permease CIG75_18715 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CIG75_18730 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CIG75_18745 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CIG75_18755 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CIG75_18760 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CIG75_18770 ENOG4105CVM Molybdenum cofactor synthesis domain protein CIG75_18790 ENOG4105BZU Histidine kinase CIG75_18795 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CIG75_18800 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CIG75_18805 ENOG4105C5H ABC transporter CIG75_18810 ENOG4107Y80 Major Facilitator superfamily CIG75_18815 ENOG4105RHY Pfam:UPF0157 CIG75_18845 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) CIG75_18850 ENOG4105C8Y Acetylornithine aminotransferase CIG75_18855 ENOG4105CAS nag kinase CIG75_18860 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CIG75_18890 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CIG75_18895 ENOG4105XSJ toxin secretion phage lysis holin CIG75_18920 ENOG41066EA baseplate J family protein CIG75_18970 ENOG4105PQS phage protein CIG75_19205 ENOG4105CDU Replicative dna helicase CIG75_19280 ENOG4108WRK Transcriptional regulator CIG75_19285 ENOG4105VTR Integrase CIG75_19295 ENOG41073R8 VanW family CIG75_19495 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CIG75_19500 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CIG75_19530 ENOG4105BZU Histidine kinase CIG75_19540 ENOG4108NMV polysaccharide deacetylase CIG75_19555 ENOG4105D1F ATP-binding protein CIG75_19570 ENOG4108UJD 30S ribosomal protein S9 CIG75_19575 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CIG75_19580 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CIG75_19585 ENOG4108ZT0 50S ribosomal protein l17 CIG75_19590 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CIG75_19595 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CIG75_19600 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CIG75_19605 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CIG75_19610 ENOG41067V7 50S ribosomal protein L36 CIG75_19615 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CIG75_19625 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CIG75_19630 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CIG75_19635 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CIG75_19640 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CIG75_19645 ENOG4105VPB 50S ribosomal protein L30 CIG75_19650 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CIG75_19655 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CIG75_19660 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CIG75_19665 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CIG75_19670 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CIG75_19675 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CIG75_19680 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CIG75_19685 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CIG75_19690 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CIG75_19695 ENOG41082SA 50s ribosomal protein l29 CIG75_19700 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CIG75_19705 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CIG75_19710 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CIG75_19715 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CIG75_19720 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CIG75_19725 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CIG75_19730 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CIG75_19735 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CIG75_19740 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CIG75_19745 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CIG75_19750 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CIG75_19755 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CIG75_19760 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CIG75_19765 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CIG75_19770 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CIG75_19775 ENOG4107Y49 methyltransferase CIG75_19780 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CIG75_19785 ENOG4108VZM 50s ribosomal protein L10 CIG75_19790 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CIG75_19795 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CIG75_19800 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CIG75_19805 ENOG410683Z Preprotein translocase SecE subunit CIG75_19810 ENOG4105WDJ 50S ribosomal protein L33 CIG75_19815 ENOG4105QIV RNA polymerase CIG75_19820 ENOG4105M0M Tetracycline resistance protein CIG75_19825 ENOG4105C2N RNA methyltransferase TrmH family group 3 CIG75_19830 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CIG75_19835 ENOG4105C8N cysteinyl-tRNA synthetase CIG75_19840 ENOG4105D7W serine acetyltransferase CIG75_19845 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CIG75_19850 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CIG75_19855 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CIG75_19860 ENOG4105CTP PilT protein domain protein CIG75_19865 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CIG75_19870 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CIG75_19875 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CIG75_19885 ENOG41066A3 ATP guanido phosphotransferase CIG75_19890 ENOG4108Z0C Uvrb UvrC protein CIG75_19900 ENOG4107XGZ Hydrolase CIG75_19905 ENOG4108IG5 Transcriptional regulator CIG75_19945 ENOG4108SDH ABC, transporter CIG75_19950 ENOG4108IUW ABC transporter CIG75_19960 ENOG4105CZV ABC transporter CIG75_20070 ENOG4105CRK lysyL-tRNA synthetase CIG75_20075 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CIG75_20085 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CIG75_20095 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CIG75_20100 ENOG4105KRF dihydroneopterin aldolase CIG75_20105 ENOG4105EEI dihydropteroate synthase CIG75_20110 ENOG4105C6T cysteine synthase CIG75_20115 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CIG75_20125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CIG75_20155 ENOG4105C22 threonyL-tRNA synthetase CIG75_20160 ENOG4105CGH 5'-nucleotidase CIG75_20190 ENOG4108IMY Transcriptional regulator CIG75_20195 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CIG75_20200 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) CIG75_20210 ENOG41060GV RNA binding s1 domain protein CIG75_20225 ENOG4105VYY sporulation protein yabp CIG75_20230 ENOG41082I2 s4 domain protein CIG75_20240 ENOG4108IY2 MazG family CIG75_20250 ENOG4108M14 stage v sporulation protein t CIG75_20270 ENOG4108JA2 transcriptioN-repair coupling factor CIG75_20280 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CIG75_20285 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CIG75_20290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CIG75_20295 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CIG75_20300 ENOG4105K4W Could be involved in septation (By similarity) CIG75_20305 ENOG4105KME endoribonuclease L-psp CIG75_20310 ENOG4105DFT pur operon repressor CIG75_20320 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CIG75_20325 ENOG4108DIG cyanophycin synthetase CIG75_20330 ENOG4105DDG Cyanophycinase CIG75_20340 ENOG4105W42 Veg protein CIG75_20345 ENOG4105XFA sporulation peptidase YabG CIG75_20355 ENOG4105DQ6 Transposase CIG75_20370 ENOG4108IPJ Membrane CIG75_20375 ENOG4105C19 ABC transporter CIG75_20425 ENOG4108XRC Protein of unknown function (DUF458) CIG75_20430 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CIG75_20435 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CIG75_20440 ENOG4105CNI cell division protein FtsW CIG75_20445 ENOG4105F8V Hydrolase, tatD family CIG75_20455 ENOG4105KRN Transcriptional regulator, abrb family CIG75_20460 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CIG75_20465 ENOG41060K3 Methyltransferase