locus-tag	class	description
CIG75_00010	COG4467	Involved in initiation control of chromosome replication
CIG75_00015	COG1774	PSP1 C-terminal conserved region
CIG75_00020	COG0470	DNA polymerase III
CIG75_00025	COG1728	Protein conserved in bacteria
CIG75_00030	COG3870	Protein conserved in bacteria
CIG75_00035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIG75_00040	COG1982	Orn Lys Arg decarboxylase major
CIG75_00065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CIG75_00075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CIG75_00080	COG3852	Histidine kinase
CIG75_00095	COG0590	tRNA wobble adenosine to inosine editing
CIG75_00120	COG1428	Deoxynucleoside kinase
CIG75_00125	COG1428	Deoxynucleoside kinase
CIG75_00135	COG3387	PFAM Glycoside hydrolase 15-related
CIG75_00140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CIG75_00150	COG1686	Belongs to the peptidase S11 family
CIG75_00155	COG0516	GMP reductase activity
CIG75_00155	COG0517	IMP dehydrogenase activity
CIG75_00190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CIG75_00195	COG0187	DNA topoisomerase II activity
CIG75_00205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIG75_00210	COG2501	S4 domain
CIG75_00215	COG0592	DNA-directed DNA polymerase activity
CIG75_00225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CIG75_00235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CIG75_00245	COG1847	R3H domain protein
CIG75_00250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CIG75_00255	COG0445	tRNA wobble uridine modification
CIG75_00260	COG0357	Ribosomal RNA small subunit methyltransferase G
CIG75_00265	COG1475	DNA binding
CIG75_00270	COG1192	Involved in chromosome partitioning
CIG75_00275	COG1475	DNA binding
CIG75_00285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CIG75_00330	COG0668	transmembrane transport
CIG75_00335	COG4481	Protein conserved in bacteria
CIG75_00340	COG0243	molybdopterin cofactor binding
CIG75_00360	COG0012	GTP binding
CIG75_00365	COG0360	Binds together with S18 to 16S ribosomal RNA
CIG75_00370	COG0629	single-stranded DNA binding
CIG75_00400	COG4941	Belongs to the sigma-70 factor family
CIG75_00410	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CIG75_00425	COG5002	protein histidine kinase activity
CIG75_00430	COG0745	RESPONSE REGULATOR receiver
CIG75_00450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIG75_00455	COG0488	(ABC) transporter
CIG75_00465	COG0626	cystathionine gamma-synthase activity
CIG75_00470	COG0484	heat shock protein binding
CIG75_00490	COG0726	polysaccharide deacetylase
CIG75_00505	COG1067	ATP-dependent peptidase activity
CIG75_00505	COG0470	DNA polymerase III
CIG75_00510	COG0305	Participates in initiation and elongation during chromosome replication
CIG75_00520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CIG75_00535	COG0745	RESPONSE REGULATOR receiver
CIG75_00540	COG5002	protein histidine kinase activity
CIG75_00545	COG4863	YycH protein
CIG75_00555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CIG75_00565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIG75_00575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CIG75_00645	COG3655	Transcriptional regulator
CIG75_00655	COG1959	2 iron, 2 sulfur cluster binding
CIG75_00665	COG1132	(ABC) transporter
CIG75_00670	COG1132	(ABC) transporter
CIG75_00690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIG75_00695	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CIG75_00715	COG1309	transcriptional regulator
CIG75_00720	COG2076	Multidrug Resistance protein
CIG75_00725	COG2076	Multidrug Resistance protein
CIG75_00745	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_00760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIG75_00790	COG0656	L-ascorbic acid biosynthetic process
CIG75_00810	COG3655	Transcriptional regulator
CIG75_00830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIG75_00845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CIG75_00850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CIG75_00865	COG0126	phosphoglycerate kinase activity
CIG75_00870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIG75_00875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CIG75_00920	COG2824	Alkylphosphonate utilization operon protein PhnA
CIG75_00930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_00930	COG2207	Transcriptional regulator
CIG75_00935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_00940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_00945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_00950	COG2819	hydrolase of the alpha beta superfamily
CIG75_00990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIG75_01000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CIG75_01005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIG75_01010	COG3832	glyoxalase III activity
CIG75_01020	COG0778	Nitroreductase
CIG75_01025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_01030	COG4605	iron ion homeostasis
CIG75_01035	COG4604	ABC transporter, ATP-binding protein
CIG75_01040	COG4607	ABC-type enterochelin transport system periplasmic component
CIG75_01045	COG1122	ATPase activity
CIG75_01050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CIG75_01060	COG0310	cobalt ion transport
CIG75_01065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_01100	COG0789	Transcriptional regulator
CIG75_01115	COG1187	pseudouridine synthase activity
CIG75_01120	COG2814	Major facilitator Superfamily
CIG75_01130	COG4895	conserved protein (DUF2196)
CIG75_01135	COG0488	(ABC) transporter
CIG75_01140	COG1214	PFAM Peptidase M22, glycoprotease
CIG75_01140	COG0456	acetyltransferase
CIG75_01155	COG1643	Atp-dependent helicase
CIG75_01190	COG0656	L-ascorbic acid biosynthetic process
CIG75_01215	COG0457	Tetratricopeptide repeat
CIG75_01215	COG0463	Glycosyl transferase, family 2
CIG75_01225	COG0463	Glycosyl transferase, family 2
CIG75_01235	COG0423	glycine-tRNA ligase activity
CIG75_01250	COG0813	purine-nucleoside phosphorylase activity
CIG75_01265	COG0861	Integral membrane protein TerC family
CIG75_01270	COG5002	protein histidine kinase activity
CIG75_01280	COG2814	Major facilitator Superfamily
CIG75_01290	COG1253	flavin adenine dinucleotide binding
CIG75_01295	COG0515	serine threonine protein kinase
CIG75_01305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIG75_01330	COG1970	mechanosensitive ion channel activity
CIG75_01335	COG2814	Major facilitator Superfamily
CIG75_01340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CIG75_01345	COG3153	acetyltransferase
CIG75_01345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIG75_01355	COG1132	(ABC) transporter
CIG75_01360	COG1132	(ABC) transporter
CIG75_01375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CIG75_01380	COG2363	Small membrane protein
CIG75_01385	COG0697	spore germination
CIG75_01400	COG0814	amino acid
CIG75_01430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIG75_01435	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIG75_01440	COG0010	Belongs to the arginase family
CIG75_01475	COG0730	response to heat
CIG75_01480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_01480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_01485	COG0425	Belongs to the sulfur carrier protein TusA family
CIG75_01490	COG2210	Belongs to the sulfur carrier protein TusA family
CIG75_01495	COG1937	Protein conserved in bacteria
CIG75_01530	COG3829	transcription factor binding
CIG75_01535	COG0604	alcohol dehydrogenase
CIG75_01540	COG1509	lysine 2,3-aminomutase activity
CIG75_01550	COG1193	negative regulation of DNA recombination
CIG75_01555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CIG75_01560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_01580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIG75_01600	COG2181	nitrate reductase activity
CIG75_01600	COG0247	lactate metabolic process
CIG75_01610	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_01615	COG1024	Enoyl-CoA hydratase
CIG75_01620	COG1960	acyl-CoA dehydrogenase activity
CIG75_01625	COG1960	acyl-CoA dehydrogenase activity
CIG75_01640	COG2131	deaminase
CIG75_01645	COG2208	phosphoserine phosphatase activity
CIG75_01650	COG2304	oxidoreductase activity
CIG75_01655	COG0515	serine threonine protein kinase
CIG75_01670	COG0037	tRNA processing
CIG75_01690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CIG75_01695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CIG75_01700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CIG75_01710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CIG75_01715	COG0242	peptide deformylase activity
CIG75_01720	COG2204	response regulator
CIG75_01725	COG1607	acyl-coa hydrolase
CIG75_01730	COG3246	L-lysine catabolic process to acetate
CIG75_01745	COG2171	N-acyltransferase activity
CIG75_01750	COG1473	amidohydrolase
CIG75_01765	COG1494	fructose-1,6-bisphosphatase
CIG75_01770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIG75_01790	COG0254	rRNA binding
CIG75_01810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CIG75_01815	COG2890	protein-(glutamine-N5) methyltransferase activity
CIG75_01830	COG0009	L-threonylcarbamoyladenylate synthase
CIG75_01860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIG75_01870	COG1132	(ABC) transporter
CIG75_01875	COG0698	ribose 5-phosphate isomerase
CIG75_01880	COG4475	Protein of unknown function (DUF436)
CIG75_01885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CIG75_01890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CIG75_01895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CIG75_01920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIG75_01925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CIG75_01930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIG75_01935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CIG75_01940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CIG75_01945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CIG75_01950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CIG75_01955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_01960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_01965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_01975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CIG75_01980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_01985	COG0839	Belongs to the complex I subunit 6 family
CIG75_01990	COG0713	ATP synthesis coupled electron transport
CIG75_01995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CIG75_02005	COG1007	ATP synthesis coupled electron transport
CIG75_02020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIG75_02030	COG2385	sporulation resulting in formation of a cellular spore
CIG75_02035	COG0739	heme binding
CIG75_02040	COG1609	Transcriptional regulator
CIG75_02045	COG1077	Cell shape determining protein MreB Mrl
CIG75_02050	COG4786	Flagellar basal body rod
CIG75_02065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIG75_02080	COG1739	Uncharacterized protein family UPF0029
CIG75_02100	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_02120	COG3693	PFAM glycoside hydrolase, family 10
CIG75_02125	COG0793	Belongs to the peptidase S41A family
CIG75_02150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CIG75_02180	COG1316	TRANSCRIPTIONal
CIG75_02195	COG1316	TRANSCRIPTIONal
CIG75_02205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CIG75_02210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIG75_02235	COG0840	transmembrane signaling receptor activity
CIG75_02245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CIG75_02250	COG0573	inorganic phosphate transmembrane transporter activity
CIG75_02255	COG0581	inorganic phosphate transmembrane transporter activity
CIG75_02260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CIG75_02265	COG0704	Plays a role in the regulation of phosphate uptake
CIG75_02270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CIG75_02275	COG0745	RESPONSE REGULATOR receiver
CIG75_02280	COG5002	protein histidine kinase activity
CIG75_02300	COG1396	sequence-specific DNA binding
CIG75_02325	COG1307	EDD domain protein, DegV family
CIG75_02330	COG1040	competence protein
CIG75_02350	COG1256	bacterial-type flagellum assembly
CIG75_02350	COG4786	Flagellar basal body rod
CIG75_02355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIG75_02365	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CIG75_02370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CIG75_02375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIG75_02380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIG75_02390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CIG75_02415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_02420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CIG75_02425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CIG75_02430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CIG75_02430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_02435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CIG75_02440	COG2089	acid synthase
CIG75_02445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIG75_02450	COG1083	cytidylyl-transferase
CIG75_02470	COG4717	serine-type aminopeptidase activity
CIG75_02475	COG0010	Belongs to the arginase family
CIG75_02485	COG0730	response to heat
CIG75_02490	COG2046	Belongs to the sulfate adenylyltransferase family
CIG75_02495	COG1595	DNA-templated transcription, initiation
CIG75_02500	COG5662	AntiSigma factor
CIG75_02510	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CIG75_02520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_02525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIG75_02540	COG2207	Transcriptional regulator
CIG75_02540	COG3708	Transcriptional regulator
CIG75_02545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_02550	COG1120	ATPase activity
CIG75_02560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_02580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CIG75_02585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIG75_02610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIG75_02615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CIG75_02620	COG0166	Belongs to the GPI family
CIG75_02625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_02635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CIG75_02640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIG75_02680	COG2814	Major facilitator Superfamily
CIG75_02720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIG75_02725	COG1695	Transcriptional regulator
CIG75_02740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_02770	COG1011	Hydrolase
CIG75_02790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIG75_02795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIG75_02795	COG4221	oxidoreductase activity
CIG75_02795	COG0300	oxidoreductase activity
CIG75_02795	COG3321	synthase
CIG75_02800	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_02800	COG0300	oxidoreductase activity
CIG75_02800	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_02800	COG3321	synthase
CIG75_02800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_02805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_02810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_02830	COG1280	lysine exporter protein (LysE YggA)
CIG75_02845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CIG75_02850	COG2814	Major facilitator Superfamily
CIG75_02855	COG4264	IucA IucC family
CIG75_02860	COG2814	Major facilitator Superfamily
CIG75_02865	COG4264	IucA IucC family
CIG75_02875	COG1475	DNA binding
CIG75_02910	COG2310	stress, protein
CIG75_02915	COG2310	stress, protein
CIG75_02920	COG2310	stress, protein
CIG75_02925	COG2310	stress, protein
CIG75_02930	COG0861	Integral membrane protein TerC family
CIG75_02945	COG1358	cellular component organization or biogenesis
CIG75_02975	COG3850	Histidine kinase
CIG75_02975	COG5002	protein histidine kinase activity
CIG75_02990	COG1840	ABC-type Fe3 transport system, periplasmic component
CIG75_03000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIG75_03010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIG75_03015	COG5609	conserved protein (DUF2294)
CIG75_03020	COG0531	amino acid
CIG75_03035	COG0477	Major facilitator Superfamily
CIG75_03040	COG3384	dioxygenase
CIG75_03045	COG2076	Multidrug Resistance protein
CIG75_03050	COG2076	Multidrug Resistance protein
CIG75_03060	COG2814	Major facilitator Superfamily
CIG75_03065	COG3973	AAA domain
CIG75_03070	COG2814	Major facilitator Superfamily
CIG75_03075	COG1876	peptidase activity
CIG75_03080	COG3973	AAA domain
CIG75_03085	COG2801	Transposase and inactivated derivatives
CIG75_03140	COG4193	domain, Protein
CIG75_03155	COG3299	homolog of phage Mu protein gp47
CIG75_03195	COG5632	N-Acetylmuramoyl-L-alanine amidase
CIG75_03250	COG1999	signal sequence binding
CIG75_03265	COG1842	Phage shock protein A
CIG75_03270	COG4758	membrane
CIG75_03275	COG4585	Histidine kinase
CIG75_03280	COG2197	response regulator
CIG75_03290	COG4991	sh3 domain protein
CIG75_03305	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIG75_03310	COG1309	transcriptional regulator
CIG75_03315	COG0640	Transcriptional regulator
CIG75_03360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIG75_03365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CIG75_03370	COG0277	FAD linked oxidase domain protein
CIG75_03375	COG4533	DNA binding
CIG75_03385	COG1132	(ABC) transporter
CIG75_03390	COG1132	(ABC) transporter
CIG75_03395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIG75_03400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CIG75_03405	COG2197	response regulator
CIG75_03410	COG4585	Histidine kinase
CIG75_03420	COG0398	Pfam SNARE associated Golgi protein
CIG75_03425	COG0464	growth
CIG75_03430	COG0165	Argininosuccinate lyase
CIG75_03435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_03455	COG4473	ABC transporter
CIG75_03460	COG1131	(ABC) transporter
CIG75_03465	COG0405	Gamma-glutamyltransferase
CIG75_03470	COG4608	Belongs to the ABC transporter superfamily
CIG75_03475	COG0444	Belongs to the ABC transporter superfamily
CIG75_03495	COG1522	sequence-specific DNA binding
CIG75_03500	COG2059	Chromate
CIG75_03505	COG0778	Nitroreductase
CIG75_03525	COG4585	Histidine kinase
CIG75_03530	COG2197	response regulator
CIG75_03535	COG1131	(ABC) transporter
CIG75_03540	COG1511	domain protein
CIG75_03540	COG0842	Transport permease protein
CIG75_03545	COG0842	Transport permease protein
CIG75_03545	COG1511	domain protein
CIG75_03550	COG0842	Transport permease protein
CIG75_03560	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_03570	COG1929	Belongs to the glycerate kinase type-1 family
CIG75_03575	COG2814	Major facilitator Superfamily
CIG75_03585	COG2258	MOSC domain
CIG75_03605	COG3973	AAA domain
CIG75_03625	COG0528	UMP kinase activity
CIG75_03630	COG2226	methyltransferase
CIG75_03635	COG0402	S-adenosylhomocysteine deaminase activity
CIG75_03640	COG1201	RNA secondary structure unwinding
CIG75_03645	COG4496	protein, YerC YecD
CIG75_03650	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CIG75_03670	COG0750	zinc metalloprotease
CIG75_03680	COG0210	DNA helicase
CIG75_03685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_03685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_03690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CIG75_03695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_03705	COG4472	Bacterial protein of unknown function (DUF965)
CIG75_03710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIG75_03715	COG0393	Putative heavy-metal-binding
CIG75_03725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIG75_03730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CIG75_03735	COG0840	transmembrane signaling receptor activity
CIG75_03745	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CIG75_03765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIG75_03765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIG75_03810	COG0778	Nitroreductase
CIG75_03825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIG75_03830	COG0154	amidase activity
CIG75_03835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIG75_03840	COG1597	lipid kinase activity
CIG75_03850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIG75_03910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIG75_03920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CIG75_03925	COG0596	Alpha beta hydrolase
CIG75_03960	COG2169	Transcriptional regulator
CIG75_03965	COG2140	Oxalate decarboxylase
CIG75_03985	COG2801	Transposase and inactivated derivatives
CIG75_04005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CIG75_04010	COG2169	Transcriptional regulator
CIG75_04015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CIG75_04025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_04030	COG1801	Protein of unknown function DUF72
CIG75_04045	COG1051	belongs to the nudix hydrolase family
CIG75_04050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_04065	COG2197	response regulator
CIG75_04070	COG4585	Histidine kinase
CIG75_04075	COG0778	Nitroreductase
CIG75_04085	COG1012	belongs to the aldehyde dehydrogenase family
CIG75_04095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CIG75_04095	COG0646	methionine synthase
CIG75_04105	COG0745	RESPONSE REGULATOR receiver
CIG75_04105	COG3706	GGDEF domain
CIG75_04150	COG1388	LysM domain
CIG75_04150	COG3858	chitin binding
CIG75_04170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CIG75_04175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CIG75_04180	COG0640	Transcriptional regulator
CIG75_04185	COG0346	lactoylglutathione lyase activity
CIG75_04240	COG3214	Protein conserved in bacteria
CIG75_04255	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIG75_04260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIG75_04280	COG2346	COG2346, Truncated hemoglobins
CIG75_04285	COG1846	Transcriptional regulator
CIG75_04290	COG0477	Major facilitator Superfamily
CIG75_04295	COG0640	Transcriptional regulator
CIG75_04300	COG0667	Aldo Keto reductase
CIG75_04320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CIG75_04355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CIG75_04360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIG75_04380	COG3339	Conserved Protein
CIG75_04385	COG0018	arginyl-trna synthetase
CIG75_04390	COG3852	Histidine kinase
CIG75_04425	COG2205	protein histidine kinase activity
CIG75_04430	COG1136	(ABC) transporter
CIG75_04445	COG1024	Enoyl-CoA hydratase
CIG75_04475	COG0514	ATP-dependent DNA helicase (RecQ)
CIG75_04485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIG75_04500	COG2801	Transposase and inactivated derivatives
CIG75_04520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_04535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_04555	COG5522	Integral membrane protein (intg_mem_TP0381)
CIG75_04560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CIG75_04570	COG5298	Protein conserved in bacteria
CIG75_04575	COG0488	(ABC) transporter
CIG75_04580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CIG75_04595	COG2333	competence protein COMEC
CIG75_04595	COG0658	competence protein
CIG75_04600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_04615	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CIG75_04620	COG1278	Cold shock
CIG75_04625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIG75_04630	COG0861	Integral membrane protein TerC family
CIG75_04645	COG1755	Isoprenylcysteine carboxyl methyltransferase
CIG75_04650	COG3424	synthase
CIG75_04660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CIG75_04665	COG0360	Binds together with S18 to 16S ribosomal RNA
CIG75_04685	COG2508	Transcriptional regulator
CIG75_04690	COG3842	ATPase activity
CIG75_04695	COG1940	carbohydrate kinase activity
CIG75_04715	COG4412	M6 family metalloprotease domain protein
CIG75_04715	COG3291	Pkd domain containing protein
CIG75_04720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIG75_04745	COG0824	Thioesterase
CIG75_04750	COG0501	Belongs to the peptidase M48B family
CIG75_04775	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIG75_04805	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIG75_04825	COG3708	Transcriptional regulator
CIG75_04825	COG2207	Transcriptional regulator
CIG75_04875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_04890	COG0288	reversible hydration of carbon dioxide
CIG75_04900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CIG75_04910	COG1595	DNA-templated transcription, initiation
CIG75_04935	COG1846	Transcriptional regulator
CIG75_04945	COG2309	aminopeptidase activity
CIG75_04950	COG1194	a g-specific adenine glycosylase
CIG75_04975	COG0670	Belongs to the BI1 family
CIG75_04985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIG75_04995	COG2186	Transcriptional regulator
CIG75_05000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIG75_05015	COG3944	biosynthesis protein
CIG75_05020	COG0438	transferase activity, transferring glycosyl groups
CIG75_05030	COG0745	RESPONSE REGULATOR receiver
CIG75_05035	COG3850	Histidine kinase
CIG75_05035	COG5002	protein histidine kinase activity
CIG75_05080	COG1012	belongs to the aldehyde dehydrogenase family
CIG75_05085	COG1408	metallophosphoesterase
CIG75_05115	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_05160	COG0561	phosphatase activity
CIG75_05185	COG3209	COG3209 Rhs family protein
CIG75_05200	COG1285	pathogenesis
CIG75_05235	COG4493	Belongs to the UPF0637 family
CIG75_05255	COG0737	Belongs to the 5'-nucleotidase family
CIG75_05260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIG75_05280	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_05285	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_05300	COG0436	Aminotransferase
CIG75_05310	COG1309	transcriptional regulator
CIG75_05315	COG0328	RNA-DNA hybrid ribonuclease activity
CIG75_05325	COG1683	Conserved Protein
CIG75_05335	COG0473	3-isopropylmalate dehydrogenase activity
CIG75_05340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CIG75_05345	COG1414	Transcriptional regulator
CIG75_05355	COG2199	diguanylate cyclase activity
CIG75_05355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CIG75_05360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CIG75_05375	COG1131	(ABC) transporter
CIG75_05380	COG1511	domain protein
CIG75_05385	COG1309	transcriptional regulator
CIG75_05390	COG2766	serine protein kinase
CIG75_05395	COG2718	Belongs to the UPF0229 family
CIG75_05400	COG2719	SpoVR family
CIG75_05430	COG1337	RAMP superfamily
CIG75_05475	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_05480	COG0189	ligase activity
CIG75_05485	COG4399	Belongs to the UPF0754 family
CIG75_05490	COG3679	Belongs to the UPF0342 family
CIG75_05495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CIG75_05510	COG4109	DRTGG domain
CIG75_05520	COG3153	acetyltransferase
CIG75_05520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIG75_05525	COG0587	DNA-directed DNA polymerase activity
CIG75_05530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CIG75_05535	COG0281	malic enzyme
CIG75_05545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CIG75_05550	COG0825	malonyl-CoA metabolic process
CIG75_05555	COG0205	6-phosphofructokinase activity
CIG75_05565	COG0824	Thioesterase
CIG75_05570	COG3030	protein affecting phage T7 exclusion by the F plasmid
CIG75_05580	COG0538	isocitrate dehydrogenase activity
CIG75_05585	COG0039	L-malate dehydrogenase activity
CIG75_05590	COG0601	transmembrane transport
CIG75_05595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIG75_05600	COG0444	Belongs to the ABC transporter superfamily
CIG75_05605	COG4608	Belongs to the ABC transporter superfamily
CIG75_05610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIG75_05610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIG75_05615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CIG75_05620	COG1971	Probably functions as a manganese efflux pump
CIG75_05625	COG0237	dephospho-CoA kinase activity
CIG75_05650	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CIG75_05660	COG0372	Belongs to the citrate synthase family
CIG75_05690	COG0517	IMP dehydrogenase activity
CIG75_05695	COG0517	IMP dehydrogenase activity
CIG75_05710	COG1543	Belongs to the glycosyl hydrolase 57 family
CIG75_05720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIG75_05740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CIG75_05750	COG0739	heme binding
CIG75_05760	COG0306	phosphate transporter
CIG75_05785	COG1979	alcohol dehydrogenase
CIG75_05790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIG75_05795	COG0436	Aminotransferase
CIG75_05800	COG1024	Enoyl-CoA hydratase
CIG75_05815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_05845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIG75_05950	COG0791	NLP P60 protein
CIG75_05955	COG1129	ABC transporter
CIG75_05970	COG0745	RESPONSE REGULATOR receiver
CIG75_05975	COG5002	protein histidine kinase activity
CIG75_05990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CIG75_05995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CIG75_06000	COG0569	domain protein
CIG75_06005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIG75_06015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CIG75_06020	COG0072	phenylalanine-tRNA ligase activity
CIG75_06020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIG75_06025	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CIG75_06040	COG1193	negative regulation of DNA recombination
CIG75_06045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIG75_06050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CIG75_06095	COG1606	tRNA processing
CIG75_06100	COG1691	(AIR) carboxylase
CIG75_06105	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CIG75_06225	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIG75_06255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CIG75_06265	COG1464	Belongs to the NlpA lipoprotein family
CIG75_06290	COG0477	Major facilitator Superfamily
CIG75_06290	COG2814	Major facilitator Superfamily
CIG75_06310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CIG75_06315	COG0632	four-way junction helicase activity
CIG75_06320	COG2255	four-way junction helicase activity
CIG75_06325	COG1191	sigma factor activity
CIG75_06340	COG2385	sporulation resulting in formation of a cellular spore
CIG75_06350	COG0343	queuine tRNA-ribosyltransferase activity
CIG75_06355	COG1862	Preprotein translocase
CIG75_06365	COG3706	GGDEF domain
CIG75_06370	COG2323	membrane
CIG75_06375	COG2244	polysaccharide biosynthetic process
CIG75_06390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIG75_06395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIG75_06400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CIG75_06400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CIG75_06405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIG75_06410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIG75_06415	COG1490	D-aminoacyl-tRNA deacylase activity
CIG75_06440	COG2814	Major facilitator Superfamily
CIG75_06490	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CIG75_06495	COG2807	transmembrane transport
CIG75_06520	COG1794	racemase activity, acting on amino acids and derivatives
CIG75_06525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIG75_06530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIG75_06535	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_06575	COG1073	alpha beta
CIG75_06585	COG1164	Oligoendopeptidase f
CIG75_06595	COG2311	Membrane
CIG75_06740	COG2814	Major facilitator Superfamily
CIG75_06750	COG2217	Heavy metal translocating P-type atpase
CIG75_06755	COG0427	acetyl-CoA hydrolase
CIG75_06770	COG5002	protein histidine kinase activity
CIG75_06785	COG0646	methionine synthase
CIG75_06785	COG1410	methionine synthase
CIG75_06795	COG1418	mRNA catabolic process
CIG75_06800	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CIG75_06810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIG75_06835	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CIG75_06840	COG3103	Sh3 type 3 domain protein
CIG75_06840	COG4991	sh3 domain protein
CIG75_06840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_06845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_06850	COG2244	polysaccharide biosynthetic process
CIG75_06860	COG0124	histidyl-tRNA synthetase
CIG75_06865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CIG75_06875	COG0024	Methionine aminopeptidase
CIG75_06895	COG2364	Membrane
CIG75_06900	COG1959	2 iron, 2 sulfur cluster binding
CIG75_06905	COG1104	cysteine desulfurase activity
CIG75_06930	COG0450	alkyl hydroperoxide reductase
CIG75_06935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_06955	COG0628	permease
CIG75_06960	COG4472	Bacterial protein of unknown function (DUF965)
CIG75_06965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CIG75_06970	COG3906	Belongs to the UPF0473 family
CIG75_06980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CIG75_06990	COG0572	uridine kinase
CIG75_06995	COG0768	penicillin binding
CIG75_07000	COG1191	sigma factor activity
CIG75_07020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CIG75_07030	COG1388	LysM domain
CIG75_07030	COG0791	NLP P60 protein
CIG75_07035	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CIG75_07040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CIG75_07050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIG75_07055	COG1534	Rna-binding protein
CIG75_07065	COG1713	HD superfamily hydrolase involved in NAD metabolism
CIG75_07070	COG0799	negative regulation of ribosome biogenesis
CIG75_07075	COG2226	methyltransferase
CIG75_07080	COG3858	chitin binding
CIG75_07080	COG1388	LysM domain
CIG75_07085	COG0495	leucyl-tRNA aminoacylation
CIG75_07095	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIG75_07100	COG1321	iron dependent repressor
CIG75_07105	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CIG75_07110	COG1555	photosystem II stabilization
CIG75_07110	COG1596	polysaccharide export
CIG75_07140	COG1595	DNA-templated transcription, initiation
CIG75_07155	COG1141	Ferredoxin
CIG75_07160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CIG75_07165	COG2084	Dehydrogenase
CIG75_07170	COG0714	Associated with various cellular activities
CIG75_07190	COG0183	Belongs to the thiolase family
CIG75_07220	COG1012	belongs to the aldehyde dehydrogenase family
CIG75_07240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIG75_07245	COG2323	membrane
CIG75_07250	COG0702	epimerase
CIG75_07325	COG0523	cobalamin synthesis protein
CIG75_07340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIG75_07365	COG0626	cystathionine gamma-synthase activity
CIG75_07375	COG1132	(ABC) transporter
CIG75_07380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CIG75_07395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CIG75_07400	COG1801	Protein of unknown function DUF72
CIG75_07410	COG1959	2 iron, 2 sulfur cluster binding
CIG75_07430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIG75_07440	COG1024	Enoyl-CoA hydratase
CIG75_07445	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_07455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_07465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CIG75_07475	COG0598	Magnesium transport protein CorA
CIG75_07525	COG1132	(ABC) transporter
CIG75_07530	COG1132	(ABC) transporter
CIG75_07535	COG2827	Endonuclease containing a URI domain
CIG75_07545	COG0387	Pfam Sodium calcium exchanger
CIG75_07550	COG0741	lytic transglycosylase activity
CIG75_07585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CIG75_07590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIG75_07595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CIG75_07595	COG1605	Chorismate mutase
CIG75_07615	COG2197	response regulator
CIG75_07645	COG3278	Belongs to the heme-copper respiratory oxidase family
CIG75_07650	COG1376	ErfK ybiS ycfS ynhG family protein
CIG75_07655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CIG75_07655	COG2199	diguanylate cyclase activity
CIG75_07660	COG0123	including yeast histone deacetylase and acetoin utilization protein
CIG75_07665	COG0517	IMP dehydrogenase activity
CIG75_07670	COG0454	-acetyltransferase
CIG75_07675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIG75_07680	COG1842	Phage shock protein A
CIG75_07690	COG0697	spore germination
CIG75_07705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIG75_07705	COG5322	oxidoreductase activity
CIG75_07710	COG3118	belongs to the thioredoxin family
CIG75_07715	COG0322	excinuclease ABC activity
CIG75_07730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIG75_07735	COG0460	homoserine dehydrogenase
CIG75_07740	COG2009	succinate dehydrogenase
CIG75_07745	COG1053	succinate dehydrogenase
CIG75_07750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CIG75_07755	COG1406	Chemotaxis phosphatase CheX
CIG75_07760	COG2197	response regulator
CIG75_07785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIG75_07790	COG1846	Transcriptional regulator
CIG75_07805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CIG75_07810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIG75_07835	COG0544	peptidyl-prolyl cis-trans isomerase activity
CIG75_07840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CIG75_07845	COG1067	ATP-dependent peptidase activity
CIG75_07845	COG0470	DNA polymerase III
CIG75_07855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CIG75_07870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIG75_07875	COG1116	anion transmembrane transporter activity
CIG75_07880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIG75_07885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CIG75_07890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIG75_07895	COG1648	precorrin-2 dehydrogenase activity
CIG75_07895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CIG75_07900	COG0181	hydroxymethylbilane synthase activity
CIG75_07910	COG0113	porphobilinogen synthase activity
CIG75_07915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIG75_07920	COG2233	PERMEase
CIG75_07925	COG2233	PERMEase
CIG75_07935	COG0564	pseudouridine synthase activity
CIG75_07960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_07970	COG1388	LysM domain
CIG75_07985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_07995	COG0791	NLP P60 protein
CIG75_08000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_08010	COG1136	(ABC) transporter
CIG75_08020	COG0525	valine-tRNA ligase activity
CIG75_08035	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CIG75_08040	COG3583	domain protein
CIG75_08040	COG3584	3D domain protein
CIG75_08055	COG1027	Aspartate ammonia-lyase
CIG75_08060	COG0424	maF-like protein
CIG75_08065	COG2003	Belongs to the UPF0758 family
CIG75_08070	COG1077	Cell shape determining protein MreB Mrl
CIG75_08075	COG1792	Involved in formation and maintenance of cell shape
CIG75_08090	COG0850	regulation of cytokinetic process
CIG75_08095	COG2894	cell division
CIG75_08110	COG1530	ribonuclease E activity
CIG75_08115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CIG75_08125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CIG75_08135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIG75_08145	COG0730	response to heat
CIG75_08155	COG1619	proteins homologs of microcin C7 resistance protein MccF
CIG75_08160	COG1408	metallophosphoesterase
CIG75_08170	COG1459	type II secretion system
CIG75_08175	COG4537	Required for transformation and DNA binding
CIG75_08210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIG75_08215	COG0367	asparagine synthase
CIG75_08220	COG4492	Belongs to the UPF0735 family
CIG75_08250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CIG75_08255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CIG75_08260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIG75_08265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIG75_08280	COG0006	proline dipeptidase activity
CIG75_08285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIG75_08300	COG2223	nitrite transmembrane transporter activity
CIG75_08305	COG0726	polysaccharide deacetylase
CIG75_08315	COG0697	spore germination
CIG75_08340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIG75_08345	COG0314	molybdopterin synthase activity
CIG75_08350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CIG75_08355	COG0315	cyclic pyranopterin monophosphate synthase activity
CIG75_08360	COG0521	Mo-molybdopterin cofactor biosynthetic process
CIG75_08375	COG0463	Glycosyl transferase, family 2
CIG75_08385	COG3858	chitin binding
CIG75_08400	COG3290	protein histidine kinase activity
CIG75_08400	COG3829	transcription factor binding
CIG75_08405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CIG75_08410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIG75_08415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIG75_08420	COG0022	dehydrogenase e1 component
CIG75_08425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIG75_08430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CIG75_08435	COG0321	lipoyl(octanoyl) transferase activity
CIG75_08450	COG0180	Tryptophanyl-tRNA synthetase
CIG75_08455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_08455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_08460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_08460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_08465	COG0346	lactoylglutathione lyase activity
CIG75_08470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIG75_08480	COG2195	Cleaves the N-terminal amino acid of tripeptides
CIG75_08485	COG0840	transmembrane signaling receptor activity
CIG75_08500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIG75_08505	COG0697	spore germination
CIG75_08520	COG2195	Cleaves the N-terminal amino acid of tripeptides
CIG75_08535	COG0494	nUDIX hydrolase
CIG75_08540	COG1379	DNA repair
CIG75_08545	COG1300	Membrane
CIG75_08555	COG0735	belongs to the Fur family
CIG75_08560	COG0686	Belongs to the AlaDH PNT family
CIG75_08570	COG4974	Belongs to the 'phage' integrase family
CIG75_08575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CIG75_08590	COG1686	Belongs to the peptidase S11 family
CIG75_08595	COG0514	ATP-dependent DNA helicase (RecQ)
CIG75_08615	COG0840	transmembrane signaling receptor activity
CIG75_08620	COG2217	Heavy metal translocating P-type atpase
CIG75_08685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_08690	COG0446	pyridine nucleotide-disulphide oxidoreductase
CIG75_08700	COG2172	sigma factor antagonist activity
CIG75_08705	COG1191	sigma factor activity
CIG75_08715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIG75_08730	COG0697	spore germination
CIG75_08740	COG3773	Cell wall hydrolase
CIG75_08740	COG3409	Peptidoglycan-binding domain 1 protein
CIG75_08745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIG75_08750	COG1686	Belongs to the peptidase S11 family
CIG75_08755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CIG75_08760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIG75_08760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIG75_08770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_08770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_08775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CIG75_08785	COG0477	Major facilitator Superfamily
CIG75_08790	COG1994	Peptidase M50
CIG75_08795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CIG75_08800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CIG75_08810	COG3874	Sporulation protein YtfJ
CIG75_08815	COG1686	Belongs to the peptidase S11 family
CIG75_08820	COG2715	membrane protein required for spore maturation
CIG75_08825	COG0700	Nucleoside recognition
CIG75_08835	COG1187	pseudouridine synthase activity
CIG75_08845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_08850	COG1333	cytochrome c biogenesis protein
CIG75_08855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIG75_08860	COG0745	RESPONSE REGULATOR receiver
CIG75_08865	COG5002	protein histidine kinase activity
CIG75_08875	COG1832	CoA-binding protein
CIG75_08885	COG0352	thiamine-phosphate diphosphorylase activity
CIG75_08895	COG2022	thiamine diphosphate biosynthetic process
CIG75_08900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CIG75_08915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_08930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIG75_08935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CIG75_08940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIG75_08960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CIG75_08995	COG0326	Molecular chaperone. Has ATPase activity
CIG75_09000	COG0681	Belongs to the peptidase S26 family
CIG75_09005	COG0431	NADPH-dependent FMN reductase
CIG75_09035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIG75_09045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIG75_09050	COG0312	modulator of DNA gyrase
CIG75_09060	COG2814	Major facilitator Superfamily
CIG75_09075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIG75_09090	COG0791	NLP P60 protein
CIG75_09090	COG1388	LysM domain
CIG75_09095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_09100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_09105	COG0300	oxidoreductase activity
CIG75_09115	COG1278	Cold shock
CIG75_09120	COG0726	polysaccharide deacetylase
CIG75_09130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIG75_09135	COG0302	gtp cyclohydrolase
CIG75_09150	COG0705	Rhomboid family
CIG75_09150	COG0457	Tetratricopeptide repeat
CIG75_09155	COG0840	transmembrane signaling receptor activity
CIG75_09165	COG3091	SprT-like family
CIG75_09180	COG0210	DNA helicase
CIG75_09215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CIG75_09225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_09230	COG0438	transferase activity, transferring glycosyl groups
CIG75_09235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_09245	COG3858	chitin binding
CIG75_09255	COG4637	Psort location Cytoplasmic, score
CIG75_09260	COG1609	Transcriptional regulator
CIG75_09265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIG75_09270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIG75_09280	COG2707	UPF0756 membrane protein
CIG75_09285	COG1809	phosphosulfolactate synthase activity
CIG75_09290	COG2814	Major facilitator Superfamily
CIG75_09295	COG0626	cystathionine gamma-synthase activity
CIG75_09300	COG0626	cystathionine gamma-synthase activity
CIG75_09305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CIG75_09315	COG2339	peptidase activity
CIG75_09320	COG3773	Cell wall hydrolase
CIG75_09320	COG3409	Peptidoglycan-binding domain 1 protein
CIG75_09325	COG2959	enzyme of heme biosynthesis
CIG75_09330	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_09345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CIG75_09360	COG1304	FMN binding
CIG75_09400	COG1160	GTP binding
CIG75_09405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIG75_09410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CIG75_09415	COG0509	glycine decarboxylation via glycine cleavage system
CIG75_09420	COG0095	Lipoate-protein ligase
CIG75_09425	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIG75_09435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIG75_09455	COG4974	Belongs to the 'phage' integrase family
CIG75_09570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_09590	COG2304	oxidoreductase activity
CIG75_09595	COG0726	polysaccharide deacetylase
CIG75_09600	COG3695	enzyme binding
CIG75_09605	COG0753	catalase activity
CIG75_09615	COG2155	Conserved Protein
CIG75_09635	COG2226	methyltransferase
CIG75_09640	COG0163	prenyltransferase activity
CIG75_09645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CIG75_09655	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CIG75_09665	COG0105	UTP biosynthetic process
CIG75_09675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIG75_09685	COG3706	GGDEF domain
CIG75_09685	COG0745	RESPONSE REGULATOR receiver
CIG75_09725	COG0438	transferase activity, transferring glycosyl groups
CIG75_09735	COG0564	pseudouridine synthase activity
CIG75_09745	COG0456	acetyltransferase
CIG75_09750	COG2855	membrane
CIG75_09765	COG2329	Antibiotic biosynthesis monooxygenase
CIG75_09780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_09810	COG0456	acetyltransferase
CIG75_09825	COG0589	response to stress
CIG75_09830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CIG75_09835	COG3383	formate dehydrogenase (NAD+) activity
CIG75_09840	COG2427	Protein of unknown function (DUF1641)
CIG75_09855	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CIG75_09855	COG0028	Belongs to the TPP enzyme family
CIG75_09860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIG75_09865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIG75_09870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIG75_09885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIG75_09895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CIG75_09900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CIG75_09920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIG75_09920	COG1199	ATP-dependent helicase activity
CIG75_09930	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CIG75_09935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CIG75_09940	COG1793	dna ligase
CIG75_09945	COG3285	dna ligase
CIG75_09945	COG1793	dna ligase
CIG75_09950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CIG75_09955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CIG75_09960	COG0235	Class ii aldolase
CIG75_09965	COG0402	S-adenosylhomocysteine deaminase activity
CIG75_09975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CIG75_09990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIG75_10000	COG0017	Asparaginyl-tRNA synthetase
CIG75_10005	COG3935	DnaD domain protein
CIG75_10015	COG0488	(ABC) transporter
CIG75_10035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CIG75_10045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIG75_10050	COG1131	(ABC) transporter
CIG75_10065	COG1595	DNA-templated transcription, initiation
CIG75_10075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIG75_10080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CIG75_10085	COG0789	Transcriptional regulator
CIG75_10090	COG0174	glutamine synthetase
CIG75_10095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIG75_10100	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_10105	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_10115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIG75_10130	COG0740	serine-type endopeptidase activity
CIG75_10140	COG0411	ABC transporter
CIG75_10150	COG0559	Belongs to the binding-protein-dependent transport system permease family
CIG75_10180	COG2247	cell wall binding repeat
CIG75_10180	COG2385	sporulation resulting in formation of a cellular spore
CIG75_10195	COG2971	BadF BadG BcrA BcrD
CIG75_10200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CIG75_10205	COG1472	Belongs to the glycosyl hydrolase 3 family
CIG75_10210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CIG75_10215	COG3876	Protein conserved in bacteria
CIG75_10220	COG1653	transport
CIG75_10225	COG1175	transmembrane transport
CIG75_10230	COG0395	ABC-type sugar transport system, permease component
CIG75_10235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIG75_10240	COG0363	glucosamine-6-phosphate deaminase activity
CIG75_10260	COG4974	Belongs to the 'phage' integrase family
CIG75_10265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIG75_10295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_10300	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_10360	COG3483	tryptophan 2,3-dioxygenase activity
CIG75_10370	COG2259	Doxx family
CIG75_10395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CIG75_10400	COG3706	GGDEF domain
CIG75_10420	COG0010	Belongs to the arginase family
CIG75_10425	COG1228	amidohydrolase
CIG75_10435	COG2986	histidine ammonia-lyase
CIG75_10450	COG0167	dihydroorotate dehydrogenase activity
CIG75_10450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CIG75_10455	COG0493	'glutamate synthase
CIG75_10505	COG1741	Belongs to the pirin family
CIG75_10535	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_10535	COG0300	oxidoreductase activity
CIG75_10535	COG3321	synthase
CIG75_10535	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_10535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_10550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIG75_10555	COG1132	(ABC) transporter
CIG75_10560	COG0464	growth
CIG75_10600	COG0464	growth
CIG75_10660	COG2070	2-Nitropropane dioxygenase
CIG75_10670	COG0477	Major facilitator Superfamily
CIG75_10730	COG0482	sulfurtransferase activity
CIG75_10735	COG1309	transcriptional regulator
CIG75_10740	COG1033	growth of symbiont in host cell
CIG75_10740	COG2409	Drug exporters of the RND superfamily
CIG75_10825	COG1923	regulation of RNA biosynthetic process
CIG75_10830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CIG75_10835	COG2136	Putative SAM-dependent methyltransferase
CIG75_10835	COG2521	methyltransferase
CIG75_10840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CIG75_10855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIG75_10865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIG75_10875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CIG75_10880	COG0287	Prephenate dehydrogenase
CIG75_10885	COG0159	tryptophan synthase activity
CIG75_10890	COG0133	tryptophan synthase activity
CIG75_10895	COG0135	phosphoribosylanthranilate isomerase activity
CIG75_10900	COG0134	indole-3-glycerol-phosphate synthase activity
CIG75_10915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CIG75_10920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CIG75_10925	COG1363	Peptidase, m42
CIG75_10930	COG1363	Peptidase, m42
CIG75_11090	COG0714	Associated with various cellular activities
CIG75_11160	COG2205	protein histidine kinase activity
CIG75_11270	COG1222	aaa ATPase
CIG75_11280	COG4208	sulfate ABC transporter
CIG75_11285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIG75_11290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CIG75_11300	COG2226	methyltransferase
CIG75_11320	COG0784	Response regulator, receiver
CIG75_11320	COG3437	response regulator, receiver
CIG75_11340	COG1233	COG1233 Phytoene dehydrogenase and related
CIG75_11350	COG0617	tRNA 3'-terminal CCA addition
CIG75_11355	COG1803	Methylglyoxal synthase
CIG75_11360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CIG75_11365	COG1694	Mazg nucleotide pyrophosphohydrolase
CIG75_11370	COG3314	Sporulation integral membrane protein YlbJ
CIG75_11375	COG1968	undecaprenyl-diphosphatase activity
CIG75_11380	COG3949	Membrane
CIG75_11385	COG0586	Pfam SNARE associated Golgi protein
CIG75_11395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIG75_11410	COG2010	Cytochrome c
CIG75_11410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIG75_11415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIG75_11430	COG5582	Belongs to the UPF0302 family
CIG75_11440	COG1061	Type III restriction enzyme res subunit
CIG75_11450	COG2112	serine threonine protein kinase
CIG75_11465	COG0688	phosphatidylethanolamine metabolic process
CIG75_11470	COG0384	phenazine biosynthesis protein PhzF
CIG75_11475	COG0189	ligase activity
CIG75_11480	COG0189	ligase activity
CIG75_11505	COG0523	cobalamin synthesis protein
CIG75_11515	COG0583	DNA-binding transcription factor activity
CIG75_11520	COG0531	amino acid
CIG75_11545	COG0613	PHP domain protein
CIG75_11555	COG2359	stage V sporulation protein S
CIG75_11560	COG1692	metallophosphoesterase
CIG75_11570	COG1418	mRNA catabolic process
CIG75_11590	COG1546	Belongs to the CinA family
CIG75_11590	COG1058	Belongs to the CinA family
CIG75_11595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIG75_11600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIG75_11605	COG1666	GTP binding
CIG75_11620	COG1426	Protein conserved in bacteria
CIG75_11635	COG0477	Major facilitator Superfamily
CIG75_11690	COG2188	Transcriptional regulator
CIG75_11695	COG4980	gas vesicle protein
CIG75_11695	COG1674	ftsk spoiiie
CIG75_11705	COG0740	serine-type endopeptidase activity
CIG75_11710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CIG75_11715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIG75_11720	COG0527	aspartate kinase activity
CIG75_11725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CIG75_11730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIG75_11735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIG75_11740	COG1873	PFAM PRC-barrel domain
CIG75_11745	COG0612	Peptidase, M16
CIG75_11750	COG0726	polysaccharide deacetylase
CIG75_11760	COG1185	polyribonucleotide nucleotidyltransferase activity
CIG75_11765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CIG75_11780	COG0196	riboflavin kinase activity
CIG75_11785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CIG75_11790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CIG75_11800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CIG75_11815	COG0195	Participates in both transcription termination and antitermination
CIG75_11820	COG0779	Required for maturation of 30S ribosomal subunits
CIG75_11825	COG2176	DNA-directed DNA polymerase activity
CIG75_11830	COG0463	Glycosyl transferase, family 2
CIG75_11835	COG0442	prolyl-tRNA aminoacylation
CIG75_11845	COG0531	amino acid
CIG75_11850	COG0584	glycerophosphoryl diester phosphodiesterase
CIG75_11855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CIG75_11870	COG4589	Belongs to the CDS family
CIG75_11875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CIG75_11880	COG0233	cytoplasmic translational termination
CIG75_11885	COG0528	UMP kinase activity
CIG75_11895	COG0052	Belongs to the universal ribosomal protein uS2 family
CIG75_11920	COG1191	sigma factor activity
CIG75_11930	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CIG75_11935	COG1776	CheC inhibitor of MCP methylation
CIG75_11940	COG0835	chemotaxis
CIG75_11945	COG0643	Histidine kinase
CIG75_11945	COG2198	Histidine kinase
CIG75_11950	COG2201	protein-glutamate methylesterase activity
CIG75_11955	COG0455	bacterial-type flagellum organization
CIG75_11960	COG1419	protein localization to endoplasmic reticulum
CIG75_11965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIG75_11970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIG75_11975	COG1684	flagellar biosynthetic protein fliR
CIG75_11980	COG1987	bacterial-type flagellum assembly
CIG75_11985	COG1338	Plays a role in the flagellum-specific transport system
CIG75_11995	COG2201	protein-glutamate methylesterase activity
CIG75_12000	COG1776	CheC inhibitor of MCP methylation
CIG75_12000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIG75_12005	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIG75_12020	COG4786	Flagellar basal body rod
CIG75_12030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CIG75_12050	COG1157	protein secretion by the type III secretion system
CIG75_12055	COG1317	bacterial-type flagellum organization
CIG75_12060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIG75_12075	COG1558	bacterial-type flagellum-dependent cell motility
CIG75_12080	COG1815	bacterial-type flagellum-dependent cell motility
CIG75_12085	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CIG75_12090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CIG75_12095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CIG75_12100	COG4974	Belongs to the 'phage' integrase family
CIG75_12105	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CIG75_12110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_12115	COG0758	DNA mediated transformation
CIG75_12120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CIG75_12145	COG2814	Major facilitator Superfamily
CIG75_12195	COG0792	nuclease activity
CIG75_12200	COG2257	FlhB HrpN YscU SpaS Family
CIG75_12210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIG75_12220	COG0681	Belongs to the peptidase S26 family
CIG75_12225	COG0335	large ribosomal subunit rRNA binding
CIG75_12235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CIG75_12240	COG1376	ErfK ybiS ycfS ynhG family protein
CIG75_12295	COG0336	Belongs to the RNA methyltransferase TrmD family
CIG75_12310	COG1837	Belongs to the UPF0109 family
CIG75_12315	COG0228	four-way junction DNA binding
CIG75_12320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CIG75_12330	COG0552	protein localization to endoplasmic reticulum
CIG75_12335	COG1196	nuclear chromosome segregation
CIG75_12345	COG0571	ribonuclease III activity
CIG75_12350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CIG75_12355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIG75_12360	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_12365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIG75_12375	COG0416	fatty acid biosynthetic process
CIG75_12385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CIG75_12400	COG3480	Lon protease (S16) C-terminal proteolytic domain
CIG75_12405	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIG75_12415	COG0742	ribosomal rna small subunit methyltransferase
CIG75_12440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CIG75_12445	COG1760	l-serine dehydratase
CIG75_12450	COG1760	l-serine dehydratase
CIG75_12455	COG1461	Dihydroxyacetone kinase
CIG75_12460	COG1302	Protein conserved in bacteria
CIG75_12465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CIG75_12475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CIG75_12480	COG1162	GTPase activity
CIG75_12485	COG0515	serine threonine protein kinase
CIG75_12485	COG2815	serine threonine protein kinase
CIG75_12490	COG0631	protein serine/threonine phosphatase activity
CIG75_12495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CIG75_12500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIG75_12500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIG75_12515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIG75_12520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIG75_12535	COG2052	Domain of unknown function (DUF370)
CIG75_12540	COG1561	YicC-like family, N-terminal region
CIG75_12550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CIG75_12570	COG1131	(ABC) transporter
CIG75_12585	COG0438	transferase activity, transferring glycosyl groups
CIG75_12590	COG0189	ligase activity
CIG75_12600	COG2382	esterase
CIG75_12620	COG0247	lactate metabolic process
CIG75_12625	COG0277	FAD linked oxidase domain protein
CIG75_12630	COG2267	carboxylic ester hydrolase activity
CIG75_12880	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CIG75_12900	COG0305	Participates in initiation and elongation during chromosome replication
CIG75_12905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CIG75_12915	COG0210	DNA helicase
CIG75_12975	COG1396	sequence-specific DNA binding
CIG75_13005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIG75_13010	COG0284	orotidine-5'-phosphate decarboxylase activity
CIG75_13015	COG0167	dihydroorotate dehydrogenase activity
CIG75_13020	COG0543	2 iron, 2 sulfur cluster binding
CIG75_13025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIG75_13035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIG75_13040	COG0540	Belongs to the ATCase OTCase family
CIG75_13050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CIG75_13055	COG0564	pseudouridine synthase activity
CIG75_13060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIG75_13065	COG1404	Belongs to the peptidase S8 family
CIG75_13175	COG3599	regulation of cell shape
CIG75_13190	COG1799	cell septum assembly
CIG75_13195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CIG75_13205	COG1873	PFAM PRC-barrel domain
CIG75_13210	COG1191	sigma factor activity
CIG75_13215	COG1191	sigma factor activity
CIG75_13240	COG2801	Transposase and inactivated derivatives
CIG75_13270	COG0644	oxidoreductase
CIG75_13290	COG0477	Major facilitator Superfamily
CIG75_13295	COG3251	PFAM MbtH domain protein
CIG75_13300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_13305	COG3433	isochorismatase activity
CIG75_13305	COG1535	isochorismatase
CIG75_13310	COG1021	2,3-dihydroxybenzoate-AMP ligase
CIG75_13315	COG1169	isochorismate synthase
CIG75_13320	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_13450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CIG75_13455	COG0849	cell division
CIG75_13460	COG3856	small basic protein
CIG75_13465	COG3879	Bacterial protein of unknown function (DUF881)
CIG75_13480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIG75_13485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CIG75_13490	COG0772	Belongs to the SEDS family
CIG75_13495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CIG75_13500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIG75_13505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CIG75_13510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIG75_13515	COG0768	penicillin binding
CIG75_13520	COG0768	penicillin binding
CIG75_13530	COG0275	rRNA processing
CIG75_13535	COG2001	Belongs to the MraZ family
CIG75_13540	COG1902	pentaerythritol trinitrate reductase activity
CIG75_13545	COG1733	regulation of RNA biosynthetic process
CIG75_13565	COG4166	transmembrane transport
CIG75_13570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIG75_13575	COG1024	Enoyl-CoA hydratase
CIG75_13580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIG75_13585	COG0511	ligase activity, forming carbon-carbon bonds
CIG75_13590	COG0439	Biotin carboxylase
CIG75_13600	COG2267	carboxylic ester hydrolase activity
CIG75_13605	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_13610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CIG75_13615	COG0316	Belongs to the HesB IscA family
CIG75_13640	COG4149	molybdate abc transporter
CIG75_13645	COG0725	ABC transporter, periplasmic molybdate-binding protein
CIG75_13650	COG0488	(ABC) transporter
CIG75_13655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIG75_13660	COG2153	protein acetylation
CIG75_13670	COG0644	oxidoreductase
CIG75_13675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CIG75_13680	COG2086	electron transfer activity
CIG75_13710	COG2203	Gaf domain
CIG75_13710	COG2199	diguanylate cyclase activity
CIG75_13720	COG4166	transmembrane transport
CIG75_13730	COG4166	transmembrane transport
CIG75_13760	COG0488	(ABC) transporter
CIG75_13830	COG0750	zinc metalloprotease
CIG75_13835	COG0497	DNA recombination
CIG75_13840	COG1438	arginine binding
CIG75_13845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CIG75_13850	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CIG75_13855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CIG75_13870	COG1722	exodeoxyribonuclease VII activity
CIG75_13880	COG0492	ferredoxin-NADP+ reductase activity
CIG75_13890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIG75_13905	COG1302	Protein conserved in bacteria
CIG75_13910	COG0439	Biotin carboxylase
CIG75_13915	COG0511	ligase activity, forming carbon-carbon bonds
CIG75_13955	COG3854	ATPases associated with a variety of cellular activities
CIG75_13960	COG1671	Belongs to the UPF0178 family
CIG75_13980	COG2226	methyltransferase
CIG75_13985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CIG75_14005	COG0494	nUDIX hydrolase
CIG75_14020	COG0515	serine threonine protein kinase
CIG75_14020	COG2815	serine threonine protein kinase
CIG75_14030	COG0454	-acetyltransferase
CIG75_14035	COG4224	UPF0291 protein
CIG75_14040	COG0301	tRNA thio-modification
CIG75_14055	COG1307	EDD domain protein, DegV family
CIG75_14065	COG0740	serine-type endopeptidase activity
CIG75_14070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_14115	COG2081	HI0933 family
CIG75_14120	COG2814	Major facilitator Superfamily
CIG75_14125	COG3442	glutamine amidotransferase
CIG75_14145	COG1376	ErfK ybiS ycfS ynhG family protein
CIG75_14155	COG0512	Glutamine amidotransferase of anthranilate synthase
CIG75_14160	COG1073	alpha beta
CIG75_14190	COG1192	Involved in chromosome partitioning
CIG75_14230	COG0840	transmembrane signaling receptor activity
CIG75_14240	COG0427	acetyl-CoA hydrolase
CIG75_14245	COG3279	Response regulator of the LytR AlgR family
CIG75_14255	COG1285	pathogenesis
CIG75_14265	COG1132	(ABC) transporter
CIG75_14285	COG3714	YhhN family
CIG75_14305	COG2233	PERMEase
CIG75_14310	COG0583	DNA-binding transcription factor activity
CIG75_14330	COG0640	Transcriptional regulator
CIG75_14345	COG0726	polysaccharide deacetylase
CIG75_14365	COG0697	spore germination
CIG75_14415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CIG75_14485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIG75_14490	COG0512	Glutamine amidotransferase of anthranilate synthase
CIG75_14495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIG75_14500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIG75_14500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CIG75_14510	COG0826	peptidase U32
CIG75_14515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CIG75_14520	COG2755	lipolytic protein G-D-S-L family
CIG75_14525	COG1131	(ABC) transporter
CIG75_14530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIG75_14535	COG0561	phosphatase activity
CIG75_14540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CIG75_14550	COG1215	transferase activity, transferring glycosyl groups
CIG75_14555	COG2268	Band 7 protein
CIG75_14570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CIG75_14575	COG4412	M6 family metalloprotease domain protein
CIG75_14575	COG3291	Pkd domain containing protein
CIG75_14590	COG0367	asparagine synthase
CIG75_14605	COG2801	Transposase and inactivated derivatives
CIG75_14615	COG1272	protein, Hemolysin III
CIG75_14630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CIG75_14635	COG2384	SAM-dependent methyltransferase
CIG75_14640	COG1960	acyl-CoA dehydrogenase activity
CIG75_14650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIG75_14655	COG0358	DNA primase activity
CIG75_14660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIG75_14660	COG0574	Belongs to the PEP-utilizing enzyme family
CIG75_14665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CIG75_14670	COG0517	IMP dehydrogenase activity
CIG75_14685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIG75_14700	COG1381	Involved in DNA repair and RecF pathway recombination
CIG75_14710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CIG75_14720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CIG75_14725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CIG75_14730	COG1480	7TM receptor with intracellular HD hydrolase
CIG75_14735	COG1702	phosphate starvation-inducible protein PhoH
CIG75_14755	COG4864	UPF0365 protein
CIG75_14760	COG1030	water channel activity
CIG75_14765	COG1610	YqeY-like protein
CIG75_14770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CIG75_14780	COG1283	sodium-dependent phosphate transmembrane transporter activity
CIG75_14785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CIG75_14790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIG75_14795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CIG75_14800	COG2264	protein methyltransferase activity
CIG75_14810	COG0443	Heat shock 70 kDa protein
CIG75_14820	COG0459	protein refolding
CIG75_14825	COG1420	regulation of RNA biosynthetic process
CIG75_14840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_14850	COG0481	GTPase activity
CIG75_14870	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_14885	COG0268	Binds directly to 16S ribosomal RNA
CIG75_14895	COG1466	dna polymerase III delta subunit
CIG75_14900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_14905	COG1252	NADH dehydrogenase
CIG75_14910	COG4294	response to UV
CIG75_14920	COG0640	Transcriptional regulator
CIG75_14925	COG5658	integral membrane protein
CIG75_14935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_14935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_14950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIG75_14955	COG0647	UMP catabolic process
CIG75_14960	COG2096	Adenosyltransferase
CIG75_15085	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIG75_15090	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIG75_15090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIG75_15095	COG0626	cystathionine gamma-synthase activity
CIG75_15100	COG3584	3D domain protein
CIG75_15120	COG1131	(ABC) transporter
CIG75_15130	COG2843	Capsule synthesis protein
CIG75_15155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIG75_15165	COG0513	Belongs to the DEAD box helicase family
CIG75_15180	COG5577	PFAM Coat F domain
CIG75_15185	COG0584	glycerophosphoryl diester phosphodiesterase
CIG75_15190	COG1725	Transcriptional regulator
CIG75_15195	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIG75_15195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIG75_15200	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIG75_15220	COG0492	ferredoxin-NADP+ reductase activity
CIG75_15225	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CIG75_15235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_15260	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CIG75_15265	COG1363	Peptidase, m42
CIG75_15280	COG3377	Domain of unknown function (DUF1805)
CIG75_15295	COG0586	Pfam SNARE associated Golgi protein
CIG75_15310	COG3639	organic phosphonate transmembrane transporter activity
CIG75_15315	COG3639	organic phosphonate transmembrane transporter activity
CIG75_15320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CIG75_15330	COG0840	transmembrane signaling receptor activity
CIG75_15335	COG0561	phosphatase activity
CIG75_15340	COG1078	dGTPase activity
CIG75_15350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CIG75_15355	COG0628	permease
CIG75_15370	COG2211	Major facilitator Superfamily
CIG75_15390	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIG75_15395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIG75_15395	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIG75_15405	COG0297	glycogen (starch) synthase activity
CIG75_15410	COG1388	LysM domain
CIG75_15410	COG3584	3D domain protein
CIG75_15415	COG1982	Orn Lys Arg decarboxylase major
CIG75_15435	COG2814	Major facilitator Superfamily
CIG75_15440	COG1126	abc transporter atp-binding protein
CIG75_15445	COG0765	amino acid transport
CIG75_15450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIG75_15460	COG1368	sulfuric ester hydrolase activity
CIG75_15465	COG0697	spore germination
CIG75_15470	COG0612	Peptidase, M16
CIG75_15475	COG1393	Belongs to the ArsC family
CIG75_15480	COG1832	CoA-binding protein
CIG75_15495	COG2357	RelA SpoT domain protein
CIG75_15500	COG2267	carboxylic ester hydrolase activity
CIG75_15505	COG0006	proline dipeptidase activity
CIG75_15515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_15550	COG1164	Oligoendopeptidase f
CIG75_15565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIG75_15570	COG0791	NLP P60 protein
CIG75_15605	COG3546	catalase activity
CIG75_15615	COG3118	belongs to the thioredoxin family
CIG75_15620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CIG75_15650	COG3033	Beta-eliminating lyase
CIG75_15655	COG3829	transcription factor binding
CIG75_15655	COG3290	protein histidine kinase activity
CIG75_15665	COG0561	phosphatase activity
CIG75_15670	COG5002	protein histidine kinase activity
CIG75_15695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CIG75_15700	COG1607	acyl-coa hydrolase
CIG75_15705	COG0346	lactoylglutathione lyase activity
CIG75_15715	COG3340	Belongs to the peptidase S51 family
CIG75_15720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_15735	COG3290	protein histidine kinase activity
CIG75_15735	COG0840	transmembrane signaling receptor activity
CIG75_15755	COG0579	oxidoreductase
CIG75_15765	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CIG75_15770	COG0235	Class ii aldolase
CIG75_15775	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CIG75_15780	COG1850	ribulose-bisphosphate carboxylase activity
CIG75_15785	COG0436	Aminotransferase
CIG75_15800	COG0640	Transcriptional regulator
CIG75_15815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_15820	COG0785	Cytochrome C biogenesis protein
CIG75_15835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIG75_15840	COG0584	glycerophosphoryl diester phosphodiesterase
CIG75_15850	COG0586	Pfam SNARE associated Golgi protein
CIG75_15865	COG5002	protein histidine kinase activity
CIG75_15870	COG0772	Belongs to the SEDS family
CIG75_15885	COG1213	nucleotidyl transferase
CIG75_15900	COG1956	GAF domain-containing protein
CIG75_15905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CIG75_15920	COG0720	synthase
CIG75_15925	COG0602	queuosine metabolic process
CIG75_15930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CIG75_15975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_15980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_15990	COG0612	Peptidase, M16
CIG75_15995	COG0612	Peptidase, M16
CIG75_16015	COG1252	NADH dehydrogenase
CIG75_16025	COG2340	Cysteine-rich secretory protein family
CIG75_16030	COG0583	DNA-binding transcription factor activity
CIG75_16035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIG75_16050	COG2222	sugar isomerase
CIG75_16055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIG75_16055	COG1213	nucleotidyl transferase
CIG75_16080	COG1703	isobutyryl-CoA mutase activity
CIG75_16080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_16080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_16085	COG1309	transcriptional regulator
CIG75_16115	COG1575	Belongs to the MenA family. Type 1 subfamily
CIG75_16120	COG0671	phosphoesterase, PA-phosphatase related
CIG75_16135	COG1122	ATPase activity
CIG75_16140	COG1122	ATPase activity
CIG75_16145	COG1960	acyl-CoA dehydrogenase activity
CIG75_16150	COG0183	Belongs to the thiolase family
CIG75_16155	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_16155	COG1024	Enoyl-CoA hydratase
CIG75_16160	COG3584	3D domain protein
CIG75_16160	COG1388	LysM domain
CIG75_16180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIG75_16200	COG1098	S1 RNA binding domain
CIG75_16205	COG3842	ATPase activity
CIG75_16215	COG5002	protein histidine kinase activity
CIG75_16230	COG4166	transmembrane transport
CIG75_16235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIG75_16260	COG1363	Peptidase, m42
CIG75_16280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIG75_16305	COG0537	adenosine 5'-monophosphoramidase activity
CIG75_16360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CIG75_16370	COG0179	Fumarylacetoacetate (FAA) hydrolase
CIG75_16375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CIG75_16385	COG0564	pseudouridine synthase activity
CIG75_16395	COG0583	DNA-binding transcription factor activity
CIG75_16400	COG0372	Belongs to the citrate synthase family
CIG75_16415	COG2211	Major facilitator Superfamily
CIG75_16420	COG2264	protein methyltransferase activity
CIG75_16430	COG0124	histidyl-tRNA synthetase
CIG75_16470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CIG75_16475	COG2086	electron transfer activity
CIG75_16480	COG1309	transcriptional regulator
CIG75_16495	COG0475	glutathione-regulated potassium exporter activity
CIG75_16510	COG0840	transmembrane signaling receptor activity
CIG75_16515	COG0840	transmembrane signaling receptor activity
CIG75_16525	COG2357	RelA SpoT domain protein
CIG75_16535	COG2309	aminopeptidase activity
CIG75_16540	COG1074	ATP-dependent DNA helicase activity
CIG75_16550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CIG75_16560	COG1595	DNA-templated transcription, initiation
CIG75_16565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CIG75_16570	COG1242	4 iron, 4 sulfur cluster binding
CIG75_16575	COG1233	COG1233 Phytoene dehydrogenase and related
CIG75_16580	COG1309	transcriptional regulator
CIG75_16595	COG2205	protein histidine kinase activity
CIG75_16600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CIG75_16605	COG1122	ATPase activity
CIG75_16610	COG4721	ABC-type cobalt transport system, permease component
CIG75_16635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIG75_16640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIG75_16655	COG0656	L-ascorbic acid biosynthetic process
CIG75_16665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIG75_16680	COG1132	(ABC) transporter
CIG75_16685	COG1132	(ABC) transporter
CIG75_16700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIG75_16715	COG0116	Belongs to the methyltransferase superfamily
CIG75_16730	COG3186	Phenylalanine-4-hydroxylase
CIG75_16745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIG75_16750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_16755	COG0436	Aminotransferase
CIG75_16760	COG1476	TRANSCRIPTIONal
CIG75_16765	COG3620	sequence-specific DNA binding
CIG75_16770	COG1607	acyl-coa hydrolase
CIG75_16790	COG2423	ornithine cyclodeaminase activity
CIG75_16795	COG4264	IucA IucC family
CIG75_16800	COG0019	diaminopimelate decarboxylase activity
CIG75_16830	COG1131	(ABC) transporter
CIG75_16835	COG1131	(ABC) transporter
CIG75_16845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_16885	COG0406	alpha-ribazole phosphatase activity
CIG75_16890	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CIG75_16955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CIG75_16960	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CIG75_16970	COG2135	peptidase activity
CIG75_16980	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_16990	COG1278	Cold shock
CIG75_16995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CIG75_17040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CIG75_17045	COG0557	exoribonuclease II activity
CIG75_17055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIG75_17060	COG0148	phosphopyruvate hydratase activity
CIG75_17070	COG0149	triose-phosphate isomerase activity
CIG75_17075	COG0126	phosphoglycerate kinase activity
CIG75_17090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CIG75_17100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CIG75_17105	COG0351	phosphomethylpyrimidine kinase
CIG75_17130	COG1368	sulfuric ester hydrolase activity
CIG75_17135	COG1573	uracil-dna glycosylase
CIG75_17160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIG75_17165	COG1481	regulation of sporulation
CIG75_17170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CIG75_17175	COG1660	Displays ATPase and GTPase activities
CIG75_17180	COG0840	transmembrane signaling receptor activity
CIG75_17190	COG0492	ferredoxin-NADP+ reductase activity
CIG75_17200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIG75_17205	COG1592	Rubrerythrin
CIG75_17220	COG0386	Belongs to the glutathione peroxidase family
CIG75_17225	COG0697	spore germination
CIG75_17245	COG1131	(ABC) transporter
CIG75_17260	COG0456	acetyltransferase
CIG75_17280	COG2197	response regulator
CIG75_17300	COG0515	serine threonine protein kinase
CIG75_17300	COG2815	serine threonine protein kinase
CIG75_17310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CIG75_17315	COG1509	lysine 2,3-aminomutase activity
CIG75_17320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIG75_17340	COG0110	maltose O-acetyltransferase activity
CIG75_17350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIG75_17355	COG1196	nuclear chromosome segregation
CIG75_17355	COG0741	lytic transglycosylase activity
CIG75_17355	COG0739	heme binding
CIG75_17365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIG75_17380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CIG75_17385	COG0556	nucleotide-excision repair
CIG75_17390	COG1360	Flagellar Motor Protein
CIG75_17395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CIG75_17405	COG0793	Belongs to the peptidase S41A family
CIG75_17405	COG3409	Peptidoglycan-binding domain 1 protein
CIG75_17410	COG1196	nuclear chromosome segregation
CIG75_17410	COG0741	lytic transglycosylase activity
CIG75_17410	COG0739	heme binding
CIG75_17415	COG2177	Part of the ABC transporter FtsEX involved in
CIG75_17420	COG2884	Cell division ATP-binding protein ftsE
CIG75_17425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CIG75_17430	COG1121	(ABC) transporter
CIG75_17435	COG0803	Belongs to the bacterial solute-binding protein 9 family
CIG75_17505	COG2409	Drug exporters of the RND superfamily
CIG75_17530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIG75_17560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIG75_17565	COG2814	Major facilitator Superfamily
CIG75_17570	COG0577	efflux transmembrane transporter activity
CIG75_17575	COG0577	efflux transmembrane transporter activity
CIG75_17575	COG1136	(ABC) transporter
CIG75_17580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIG75_17590	COG0165	Argininosuccinate lyase
CIG75_17595	COG0137	argininosuccinate synthase activity
CIG75_17600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CIG75_17605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIG75_17660	COG2247	cell wall binding repeat
CIG75_17660	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_17665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CIG75_17670	COG0456	acetyltransferase
CIG75_17675	COG1214	PFAM Peptidase M22, glycoprotease
CIG75_17680	COG0802	atpase or kinase
CIG75_17685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CIG75_17690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CIG75_17700	COG2808	Putative FMN-binding domain
CIG75_17705	COG0588	phosphoglycerate mutase activity
CIG75_17720	COG2183	response to ionizing radiation
CIG75_17725	COG0671	phosphoesterase, PA-phosphatase related
CIG75_17730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIG75_17740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIG75_17775	COG1473	amidohydrolase
CIG75_17780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CIG75_17785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CIG75_17790	COG0745	RESPONSE REGULATOR receiver
CIG75_17790	COG3706	GGDEF domain
CIG75_17795	COG3359	exonuclease
CIG75_17840	COG2801	Transposase and inactivated derivatives
CIG75_17865	COG1205	dead DEAH box helicase
CIG75_17865	COG1111	helicase
CIG75_17875	COG0735	belongs to the Fur family
CIG75_17885	COG2197	response regulator
CIG75_17890	COG4585	Histidine kinase
CIG75_17905	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CIG75_17910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CIG75_17925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIG75_17935	COG2337	Toxic component of a toxin-antitoxin (TA) module
CIG75_17940	COG0864	Transcriptional regulator
CIG75_17945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIG75_17950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CIG75_17960	COG2050	protein possibly involved in aromatic compounds catabolism
CIG75_17975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIG75_17980	COG1131	(ABC) transporter
CIG75_17995	COG1131	(ABC) transporter
CIG75_18015	COG2267	carboxylic ester hydrolase activity
CIG75_18025	COG0861	Integral membrane protein TerC family
CIG75_18050	COG0217	transcriptional regulatory protein
CIG75_18055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CIG75_18060	COG2814	Major facilitator Superfamily
CIG75_18100	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_18105	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_18120	COG1024	Enoyl-CoA hydratase
CIG75_18160	COG0477	Major facilitator Superfamily
CIG75_18285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_18300	COG2801	Transposase and inactivated derivatives
CIG75_18365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_18370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_18385	COG2323	membrane
CIG75_18395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIG75_18460	COG0166	Belongs to the GPI family
CIG75_18480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CIG75_18490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CIG75_18495	COG0438	transferase activity, transferring glycosyl groups
CIG75_18510	COG0438	transferase activity, transferring glycosyl groups
CIG75_18540	COG1073	alpha beta
CIG75_18550	COG3850	Histidine kinase
CIG75_18550	COG5002	protein histidine kinase activity
CIG75_18555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIG75_18560	COG0583	DNA-binding transcription factor activity
CIG75_18600	COG2814	Major facilitator Superfamily
CIG75_18610	COG0861	Integral membrane protein TerC family
CIG75_18620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIG75_18645	COG0151	Belongs to the GarS family
CIG75_18650	COG0138	bifunctional purine biosynthesis protein purh
CIG75_18655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CIG75_18660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CIG75_18665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CIG75_18670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIG75_18675	COG0047	phosphoribosylformylglycinamidine synthase activity
CIG75_18680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIG75_18685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CIG75_18690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CIG75_18695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CIG75_18710	COG2252	PERMEase
CIG75_18715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIG75_18715	COG0519	Catalyzes the synthesis of GMP from XMP
CIG75_18720	COG1305	Transglutaminase-like
CIG75_18730	COG0714	Associated with various cellular activities
CIG75_18745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CIG75_18755	COG0805	protein transport
CIG75_18760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIG75_18770	COG0303	'Molybdopterin
CIG75_18790	COG0745	RESPONSE REGULATOR receiver
CIG75_18790	COG3706	GGDEF domain
CIG75_18795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CIG75_18800	COG0671	phosphoesterase, PA-phosphatase related
CIG75_18805	COG0488	(ABC) transporter
CIG75_18810	COG2814	Major facilitator Superfamily
CIG75_18815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CIG75_18825	COG0028	Belongs to the TPP enzyme family
CIG75_18845	COG1612	heme a metabolic process
CIG75_18850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIG75_18855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIG75_18860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CIG75_18895	COG4824	toxin secretion phage lysis holin
CIG75_18920	COG3299	homolog of phage Mu protein gp47
CIG75_19205	COG0305	Participates in initiation and elongation during chromosome replication
CIG75_19280	COG1396	sequence-specific DNA binding
CIG75_19285	COG0582	viral genome integration into host DNA
CIG75_19295	COG2720	vancomycin resistance protein
CIG75_19495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CIG75_19500	COG0653	protein targeting
CIG75_19540	COG0726	polysaccharide deacetylase
CIG75_19555	COG0489	protein tyrosine kinase activity
CIG75_19565	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_19570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CIG75_19575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CIG75_19580	COG0101	tRNA pseudouridine synthase activity
CIG75_19585	COG0203	ribosomal protein L17
CIG75_19590	COG0202	RNA polymerase activity
CIG75_19595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CIG75_19600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CIG75_19605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CIG75_19610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CIG75_19615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CIG75_19625	COG0024	Methionine aminopeptidase
CIG75_19630	COG0563	adenylate kinase activity
CIG75_19635	COG0201	protein transport
CIG75_19640	COG0200	Binds to the 23S rRNA
CIG75_19645	COG1841	ribosomal large subunit assembly
CIG75_19650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CIG75_19655	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CIG75_19660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CIG75_19665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CIG75_19675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CIG75_19680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CIG75_19685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CIG75_19690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CIG75_19695	COG0255	Belongs to the universal ribosomal protein uL29 family
CIG75_19700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CIG75_19705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CIG75_19715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CIG75_19720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CIG75_19725	COG0089	rRNA binding
CIG75_19730	COG0088	Forms part of the polypeptide exit tunnel
CIG75_19735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CIG75_19740	COG0051	transcription antitermination factor activity, RNA binding
CIG75_19745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIG75_19750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CIG75_19755	COG0049	tRNA binding
CIG75_19760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CIG75_19765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIG75_19770	COG0085	RNA polymerase activity
CIG75_19775	COG2813	Specifically methylates the guanine in position
CIG75_19780	COG0222	ribosome binding
CIG75_19785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CIG75_19790	COG0081	regulation of translation
CIG75_19795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CIG75_19800	COG0250	Participates in transcription elongation, termination and antitermination
CIG75_19805	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIG75_19810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CIG75_19820	COG3688	RNA-binding protein containing a PIN domain
CIG75_19825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIG75_19830	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CIG75_19835	COG0215	cysteine-tRNA ligase activity
CIG75_19840	COG1045	serine acetyltransferase
CIG75_19845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIG75_19850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CIG75_19855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CIG75_19860	COG4956	integral membrane protein (PIN domain superfamily)
CIG75_19865	COG1183	phosphatidylcholine synthase activity
CIG75_19870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CIG75_19875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CIG75_19880	COG0542	response to heat
CIG75_19885	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CIG75_19890	COG3880	PFAM UvrB UvrC protein
CIG75_19900	COG0546	phosphoglycolate phosphatase activity
CIG75_19905	COG1309	transcriptional regulator
CIG75_19945	COG1668	transmembrane transport
CIG75_19950	COG4555	ABC transporter
CIG75_19960	COG1131	(ABC) transporter
CIG75_20070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CIG75_20075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIG75_20085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIG75_20095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CIG75_20100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CIG75_20105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CIG75_20110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_20115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CIG75_20135	COG1595	DNA-templated transcription, initiation
CIG75_20145	COG1131	(ABC) transporter
CIG75_20155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIG75_20160	COG0737	Belongs to the 5'-nucleotidase family
CIG75_20190	COG1396	sequence-specific DNA binding
CIG75_20195	COG0504	CTP synthase activity
CIG75_20200	COG3343	RNA polymerase activity
CIG75_20210	COG1098	S1 RNA binding domain
CIG75_20230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CIG75_20240	COG3956	TIGRFAM MazG family protein
CIG75_20245	COG2244	polysaccharide biosynthetic process
CIG75_20250	COG2002	toxin-antitoxin pair type II binding
CIG75_20270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CIG75_20280	COG0193	aminoacyl-tRNA hydrolase activity
CIG75_20285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CIG75_20290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIG75_20295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CIG75_20300	COG2088	sporulation resulting in formation of a cellular spore
CIG75_20305	COG0251	oxidation-reduction process
CIG75_20310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIG75_20320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CIG75_20325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIG75_20325	COG0189	ligase activity
CIG75_20340	COG4466	Protein conserved in bacteria
CIG75_20355	COG2801	Transposase and inactivated derivatives
CIG75_20370	COG0697	spore germination
CIG75_20375	COG1136	(ABC) transporter
CIG75_20425	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CIG75_20430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CIG75_20435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CIG75_20440	COG0772	Belongs to the SEDS family
CIG75_20445	COG0084	hydrolase, TatD family'
CIG75_20455	COG2002	toxin-antitoxin pair type II binding
CIG75_20460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CIG75_20465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)