locus-tag	class	description
CBW65_00190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CBW65_00195	COG1691	(AIR) carboxylase
CBW65_00200	COG1606	tRNA processing
CBW65_00235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBW65_00240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CBW65_00250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBW65_00255	COG1193	negative regulation of DNA recombination
CBW65_00270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CBW65_00275	COG0072	phenylalanine-tRNA ligase activity
CBW65_00275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBW65_00280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CBW65_00290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBW65_00295	COG0569	domain protein
CBW65_00300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CBW65_00305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CBW65_00325	COG5002	protein histidine kinase activity
CBW65_00330	COG0745	RESPONSE REGULATOR receiver
CBW65_00350	COG0791	NLP P60 protein
CBW65_00390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CBW65_00435	COG1024	Enoyl-CoA hydratase
CBW65_00440	COG0436	Aminotransferase
CBW65_00445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBW65_00460	COG1979	alcohol dehydrogenase
CBW65_00490	COG0306	phosphate transporter
CBW65_00510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CBW65_00530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBW65_00535	COG1543	Belongs to the glycosyl hydrolase 57 family
CBW65_00550	COG0517	IMP dehydrogenase activity
CBW65_00555	COG0517	IMP dehydrogenase activity
CBW65_00575	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_00575	COG2247	cell wall binding repeat
CBW65_00590	COG0372	Belongs to the citrate synthase family
CBW65_00600	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CBW65_00625	COG0237	dephospho-CoA kinase activity
CBW65_00630	COG1971	Probably functions as a manganese efflux pump
CBW65_00635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CBW65_00640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBW65_00640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBW65_00645	COG4608	Belongs to the ABC transporter superfamily
CBW65_00650	COG0444	Belongs to the ABC transporter superfamily
CBW65_00655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBW65_00660	COG0601	transmembrane transport
CBW65_00665	COG0039	L-malate dehydrogenase activity
CBW65_00670	COG0538	isocitrate dehydrogenase activity
CBW65_00685	COG0824	Thioesterase
CBW65_00700	COG0825	malonyl-CoA metabolic process
CBW65_00705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CBW65_00715	COG0281	malic enzyme
CBW65_00720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CBW65_00725	COG0587	DNA-directed DNA polymerase activity
CBW65_00730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_00730	COG3153	acetyltransferase
CBW65_00740	COG4109	DRTGG domain
CBW65_00755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_00760	COG3679	Belongs to the UPF0342 family
CBW65_00775	COG0189	ligase activity
CBW65_00790	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_00820	COG2719	SpoVR family
CBW65_00825	COG2718	Belongs to the UPF0229 family
CBW65_00830	COG2766	serine protein kinase
CBW65_00835	COG1309	transcriptional regulator
CBW65_00840	COG1511	domain protein
CBW65_00845	COG1131	(ABC) transporter
CBW65_00860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CBW65_00865	COG2199	diguanylate cyclase activity
CBW65_00865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CBW65_00875	COG1414	Transcriptional regulator
CBW65_00880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CBW65_00885	COG0538	isocitrate dehydrogenase activity
CBW65_00895	COG1683	Conserved Protein
CBW65_00905	COG0328	RNA-DNA hybrid ribonuclease activity
CBW65_00910	COG1309	transcriptional regulator
CBW65_00920	COG0436	Aminotransferase
CBW65_00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_00960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBW65_00965	COG0737	Belongs to the 5'-nucleotidase family
CBW65_00990	COG4493	Belongs to the UPF0637 family
CBW65_01035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CBW65_01040	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CBW65_01045	COG1285	pathogenesis
CBW65_01075	COG0561	phosphatase activity
CBW65_01095	COG1122	ATPase activity
CBW65_01130	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_01160	COG1408	metallophosphoesterase
CBW65_01165	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_01175	COG0706	membrane insertase activity
CBW65_01210	COG1301	dicarboxylic acid transport
CBW65_01220	COG0438	transferase activity, transferring glycosyl groups
CBW65_01225	COG3944	biosynthesis protein
CBW65_01240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBW65_01245	COG2186	Transcriptional regulator
CBW65_01255	COG1509	lysine 2,3-aminomutase activity
CBW65_01260	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CBW65_01265	COG1126	abc transporter atp-binding protein
CBW65_01275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBW65_01280	COG0456	acetyltransferase
CBW65_01285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CBW65_01295	COG0670	Belongs to the BI1 family
CBW65_01320	COG1194	a g-specific adenine glycosylase
CBW65_01330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_01335	COG2309	aminopeptidase activity
CBW65_01350	COG1846	Transcriptional regulator
CBW65_01370	COG1595	DNA-templated transcription, initiation
CBW65_01380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBW65_01390	COG0288	reversible hydration of carbon dioxide
CBW65_01405	COG2226	methyltransferase
CBW65_01450	COG2207	Transcriptional regulator
CBW65_01450	COG3708	Transcriptional regulator
CBW65_01465	COG3708	Transcriptional regulator
CBW65_01465	COG2207	Transcriptional regulator
CBW65_01475	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBW65_01500	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBW65_01530	COG0492	ferredoxin-NADP+ reductase activity
CBW65_01540	COG0501	Belongs to the peptidase M48B family
CBW65_01545	COG0824	Thioesterase
CBW65_01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBW65_01580	COG4412	M6 family metalloprotease domain protein
CBW65_01580	COG3291	Pkd domain containing protein
CBW65_01605	COG1940	carbohydrate kinase activity
CBW65_01610	COG3842	ATPase activity
CBW65_01615	COG2508	Transcriptional regulator
CBW65_01620	COG0534	Mate efflux family protein
CBW65_01630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CBW65_01640	COG0697	spore germination
CBW65_01655	COG0360	Binds together with S18 to 16S ribosomal RNA
CBW65_01660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CBW65_01680	COG3424	synthase
CBW65_01685	COG1755	Isoprenylcysteine carboxyl methyltransferase
CBW65_01690	COG3906	Belongs to the UPF0473 family
CBW65_01700	COG0861	Integral membrane protein TerC family
CBW65_01720	COG1278	Cold shock
CBW65_01725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CBW65_01740	COG3069	C4-dicarboxylate transmembrane transporter activity
CBW65_01750	COG1131	(ABC) transporter
CBW65_01755	COG1309	transcriptional regulator
CBW65_01760	COG1732	Glycine betaine
CBW65_01765	COG1174	glycine betaine transport
CBW65_01770	COG0517	IMP dehydrogenase activity
CBW65_01770	COG1125	glycine betaine transport
CBW65_01780	COG2333	competence protein COMEC
CBW65_01780	COG0658	competence protein
CBW65_01795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CBW65_01800	COG0488	(ABC) transporter
CBW65_01820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CBW65_01825	COG5522	Integral membrane protein (intg_mem_TP0381)
CBW65_01855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_01865	COG0745	RESPONSE REGULATOR receiver
CBW65_01870	COG2205	protein histidine kinase activity
CBW65_01885	COG1733	regulation of RNA biosynthetic process
CBW65_01890	COG2259	Doxx family
CBW65_01895	COG1741	Belongs to the pirin family
CBW65_01910	COG0346	lactoylglutathione lyase activity
CBW65_01915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_01945	COG1484	DNA-dependent DNA replication
CBW65_01985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CBW65_02000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CBW65_02035	COG1484	DNA-dependent DNA replication
CBW65_02060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CBW65_02070	COG0514	ATP-dependent DNA helicase (RecQ)
CBW65_02100	COG1024	Enoyl-CoA hydratase
CBW65_02115	COG1136	(ABC) transporter
CBW65_02115	COG0577	efflux transmembrane transporter activity
CBW65_02120	COG2205	protein histidine kinase activity
CBW65_02125	COG0745	RESPONSE REGULATOR receiver
CBW65_02130	COG1279	arginine transmembrane transporter activity
CBW65_02135	COG3437	response regulator, receiver
CBW65_02170	COG3852	Histidine kinase
CBW65_02175	COG0018	arginyl-trna synthetase
CBW65_02180	COG3339	Conserved Protein
CBW65_02255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CBW65_02260	COG4191	Histidine kinase
CBW65_02265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CBW65_02280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBW65_02285	COG0765	amino acid transport
CBW65_02290	COG0765	amino acid transport
CBW65_02295	COG4191	Histidine kinase
CBW65_02300	COG0784	Response regulator, receiver
CBW65_02345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CBW65_02365	COG0667	Aldo Keto reductase
CBW65_02370	COG0640	Transcriptional regulator
CBW65_02375	COG0477	Major facilitator Superfamily
CBW65_02385	COG2346	COG2346, Truncated hemoglobins
CBW65_02405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBW65_02410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBW65_02425	COG3214	Protein conserved in bacteria
CBW65_02435	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_02485	COG0346	lactoylglutathione lyase activity
CBW65_02490	COG0640	Transcriptional regulator
CBW65_02495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBW65_02500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CBW65_02535	COG3942	CHAP domain
CBW65_02535	COG1388	LysM domain
CBW65_02600	COG5444	nuclease activity
CBW65_02670	COG0745	RESPONSE REGULATOR receiver
CBW65_02670	COG3706	GGDEF domain
CBW65_02690	COG3706	GGDEF domain
CBW65_02690	COG0745	RESPONSE REGULATOR receiver
CBW65_02730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CBW65_02730	COG0646	methionine synthase
CBW65_02735	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_02750	COG0778	Nitroreductase
CBW65_02785	COG5002	protein histidine kinase activity
CBW65_02820	COG1801	Protein of unknown function DUF72
CBW65_02830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_02855	COG5646	InterPro IPR014922
CBW65_02860	COG0288	reversible hydration of carbon dioxide
CBW65_02865	COG4326	sporulation control protein
CBW65_02875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CBW65_02885	COG1597	lipid kinase activity
CBW65_02890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CBW65_02895	COG0154	amidase activity
CBW65_02900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CBW65_02915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_02925	COG0778	Nitroreductase
CBW65_02945	COG0783	Belongs to the Dps family
CBW65_03000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_03045	COG3813	Protein conserved in bacteria
CBW65_03060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBW65_03060	COG2169	Transcriptional regulator
CBW65_03065	COG0346	lactoylglutathione lyase activity
CBW65_03085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CBW65_03100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CBW65_03105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CBW65_03110	COG2070	2-Nitropropane dioxygenase
CBW65_03115	COG0393	Putative heavy-metal-binding
CBW65_03120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBW65_03135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_03140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CBW65_03145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_03145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_03150	COG0210	DNA helicase
CBW65_03160	COG0750	zinc metalloprotease
CBW65_03180	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CBW65_03185	COG4496	protein, YerC YecD
CBW65_03195	COG1201	RNA secondary structure unwinding
CBW65_03200	COG0402	S-adenosylhomocysteine deaminase activity
CBW65_03205	COG2226	methyltransferase
CBW65_03210	COG0528	UMP kinase activity
CBW65_03230	COG3973	AAA domain
CBW65_03250	COG2258	MOSC domain
CBW65_03260	COG2814	Major facilitator Superfamily
CBW65_03270	COG1929	Belongs to the glycerate kinase type-1 family
CBW65_03280	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_03295	COG0842	Transport permease protein
CBW65_03300	COG1511	domain protein
CBW65_03300	COG0842	Transport permease protein
CBW65_03305	COG1131	(ABC) transporter
CBW65_03310	COG2197	response regulator
CBW65_03315	COG4585	Histidine kinase
CBW65_03325	COG4085	toxin activity
CBW65_03325	COG0737	Belongs to the 5'-nucleotidase family
CBW65_03325	COG1525	nuclease
CBW65_03335	COG0778	Nitroreductase
CBW65_03340	COG3647	Membrane
CBW65_03345	COG2059	Chromate
CBW65_03350	COG0405	Gamma-glutamyltransferase
CBW65_03355	COG1131	(ABC) transporter
CBW65_03360	COG4473	ABC transporter
CBW65_03375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBW65_03380	COG0165	Argininosuccinate lyase
CBW65_03385	COG0464	growth
CBW65_03390	COG0398	Pfam SNARE associated Golgi protein
CBW65_03410	COG1309	transcriptional regulator
CBW65_03420	COG4585	Histidine kinase
CBW65_03425	COG2197	response regulator
CBW65_03430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CBW65_03435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CBW65_03445	COG1132	(ABC) transporter
CBW65_03450	COG1132	(ABC) transporter
CBW65_03455	COG4533	DNA binding
CBW65_03485	COG0277	FAD linked oxidase domain protein
CBW65_03490	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CBW65_03495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBW65_03520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_03530	COG1917	Cupin 2, conserved barrel domain protein
CBW65_03530	COG1396	sequence-specific DNA binding
CBW65_03540	COG0640	Transcriptional regulator
CBW65_03545	COG1309	transcriptional regulator
CBW65_03555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_03560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBW65_03565	COG4166	transmembrane transport
CBW65_03570	COG4991	sh3 domain protein
CBW65_03590	COG1136	(ABC) transporter
CBW65_03615	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_03630	COG0300	oxidoreductase activity
CBW65_03630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBW65_03630	COG4221	oxidoreductase activity
CBW65_03630	COG3321	synthase
CBW65_03655	COG0659	secondary active sulfate transmembrane transporter activity
CBW65_03660	COG0589	response to stress
CBW65_03665	COG2197	response regulator
CBW65_03670	COG4585	Histidine kinase
CBW65_03675	COG4758	membrane
CBW65_03680	COG1842	Phage shock protein A
CBW65_03715	COG1999	signal sequence binding
CBW65_03760	COG3973	AAA domain
CBW65_03765	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CBW65_03770	COG1876	peptidase activity
CBW65_03775	COG2814	Major facilitator Superfamily
CBW65_03785	COG3973	AAA domain
CBW65_03790	COG2124	cytochrome p450
CBW65_03795	COG2814	Major facilitator Superfamily
CBW65_03800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CBW65_03805	COG2076	Multidrug Resistance protein
CBW65_03810	COG2076	Multidrug Resistance protein
CBW65_03815	COG3384	dioxygenase
CBW65_03820	COG0477	Major facilitator Superfamily
CBW65_03855	COG1741	Belongs to the pirin family
CBW65_03865	COG0672	)-iron permease
CBW65_03870	COG2837	iron assimilation
CBW65_03875	COG2822	iron ion transport
CBW65_03900	COG0640	Transcriptional regulator
CBW65_04005	COG1937	Protein conserved in bacteria
CBW65_04010	COG2210	Belongs to the sulfur carrier protein TusA family
CBW65_04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CBW65_04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_04030	COG0730	response to heat
CBW65_04040	COG0425	Belongs to the sulfur carrier protein TusA family
CBW65_04050	COG2226	methyltransferase
CBW65_04065	COG3850	Histidine kinase
CBW65_04065	COG5002	protein histidine kinase activity
CBW65_04100	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CBW65_04105	COG0492	ferredoxin-NADP+ reductase activity
CBW65_04130	COG1358	cellular component organization or biogenesis
CBW65_04145	COG0861	Integral membrane protein TerC family
CBW65_04150	COG2310	stress, protein
CBW65_04155	COG2310	stress, protein
CBW65_04160	COG2310	stress, protein
CBW65_04165	COG2310	stress, protein
CBW65_04170	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CBW65_04175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBW65_04225	COG1357	PFAM Pentapeptide repeats (8 copies)
CBW65_04235	COG0574	Belongs to the PEP-utilizing enzyme family
CBW65_04235	COG3848	Pyruvate phosphate dikinase
CBW65_04240	COG0574	Belongs to the PEP-utilizing enzyme family
CBW65_04240	COG3848	Pyruvate phosphate dikinase
CBW65_04245	COG2814	Major facilitator Superfamily
CBW65_04260	COG1595	DNA-templated transcription, initiation
CBW65_04270	COG0477	Major facilitator Superfamily
CBW65_04275	COG1064	alcohol dehydrogenase
CBW65_04280	COG2409	Drug exporters of the RND superfamily
CBW65_04290	COG3708	Transcriptional regulator
CBW65_04290	COG2207	Transcriptional regulator
CBW65_04320	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_04340	COG0166	Belongs to the GPI family
CBW65_04345	COG1032	radical SAM domain protein
CBW65_04360	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_04370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBW65_04375	COG2226	methyltransferase
CBW65_04395	COG0612	Peptidase, M16
CBW65_04400	COG1132	(ABC) transporter
CBW65_04405	COG1132	(ABC) transporter
CBW65_04440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBW65_04450	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CBW65_04460	COG5662	AntiSigma factor
CBW65_04465	COG1595	DNA-templated transcription, initiation
CBW65_04485	COG0730	response to heat
CBW65_04490	COG0175	sulfate reduction
CBW65_04495	COG0010	Belongs to the arginase family
CBW65_04500	COG4717	serine-type aminopeptidase activity
CBW65_04520	COG1083	cytidylyl-transferase
CBW65_04525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBW65_04530	COG2089	acid synthase
CBW65_04535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CBW65_04540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBW65_04560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CBW65_04565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBW65_04595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_04600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_04605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_04610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CBW65_04615	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CBW65_04625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_04630	COG4786	Flagellar basal body rod
CBW65_04630	COG1256	bacterial-type flagellum assembly
CBW65_04650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBW65_04655	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_04660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBW65_04665	COG1040	competence protein
CBW65_04670	COG1307	EDD domain protein, DegV family
CBW65_04685	COG5002	protein histidine kinase activity
CBW65_04690	COG0745	RESPONSE REGULATOR receiver
CBW65_04695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CBW65_04700	COG0704	Plays a role in the regulation of phosphate uptake
CBW65_04705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CBW65_04710	COG0581	inorganic phosphate transmembrane transporter activity
CBW65_04715	COG0573	inorganic phosphate transmembrane transporter activity
CBW65_04720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CBW65_04740	COG0697	spore germination
CBW65_04770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBW65_04790	COG1316	TRANSCRIPTIONal
CBW65_04805	COG1316	TRANSCRIPTIONal
CBW65_04850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CBW65_04880	COG3409	Peptidoglycan-binding domain 1 protein
CBW65_04880	COG0793	Belongs to the peptidase S41A family
CBW65_04885	COG3693	PFAM glycoside hydrolase, family 10
CBW65_05015	COG1739	Uncharacterized protein family UPF0029
CBW65_05030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBW65_05035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBW65_05045	COG4786	Flagellar basal body rod
CBW65_05050	COG1077	Cell shape determining protein MreB Mrl
CBW65_05055	COG1609	Transcriptional regulator
CBW65_05060	COG0739	heme binding
CBW65_05065	COG2385	sporulation resulting in formation of a cellular spore
CBW65_05070	COG0739	heme binding
CBW65_05075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CBW65_05090	COG1007	ATP synthesis coupled electron transport
CBW65_05100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CBW65_05105	COG0713	ATP synthesis coupled electron transport
CBW65_05110	COG0839	Belongs to the complex I subunit 6 family
CBW65_05115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_05120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CBW65_05130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_05135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_05140	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_05150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CBW65_05155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CBW65_05160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CBW65_05165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBW65_05170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CBW65_05175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBW65_05200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBW65_05205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CBW65_05210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CBW65_05220	COG0698	ribose 5-phosphate isomerase
CBW65_05225	COG1132	(ABC) transporter
CBW65_05230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CBW65_05255	COG0009	L-threonylcarbamoyladenylate synthase
CBW65_05275	COG2890	protein-(glutamine-N5) methyltransferase activity
CBW65_05280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CBW65_05285	COG3872	metal-dependent enzyme
CBW65_05290	COG0697	spore germination
CBW65_05310	COG1435	thymidine kinase activity
CBW65_05315	COG0254	rRNA binding
CBW65_05335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CBW65_05340	COG1494	fructose-1,6-bisphosphatase
CBW65_05365	COG1473	amidohydrolase
CBW65_05370	COG2171	N-acyltransferase activity
CBW65_05385	COG3246	L-lysine catabolic process to acetate
CBW65_05390	COG1607	acyl-coa hydrolase
CBW65_05395	COG2204	response regulator
CBW65_05405	COG0242	peptide deformylase activity
CBW65_05410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CBW65_05420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CBW65_05425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CBW65_05430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CBW65_05440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBW65_05450	COG0037	tRNA processing
CBW65_05470	COG0515	serine threonine protein kinase
CBW65_05475	COG2304	oxidoreductase activity
CBW65_05480	COG2208	phosphoserine phosphatase activity
CBW65_05485	COG2131	deaminase
CBW65_05500	COG1960	acyl-CoA dehydrogenase activity
CBW65_05505	COG1960	acyl-CoA dehydrogenase activity
CBW65_05510	COG1024	Enoyl-CoA hydratase
CBW65_05515	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_05520	COG0183	Belongs to the thiolase family
CBW65_05525	COG2181	nitrate reductase activity
CBW65_05525	COG0247	lactate metabolic process
CBW65_05535	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CBW65_05565	COG0601	transmembrane transport
CBW65_05570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBW65_05585	COG1131	(ABC) transporter
CBW65_05610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_05615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CBW65_05620	COG1193	negative regulation of DNA recombination
CBW65_05630	COG1509	lysine 2,3-aminomutase activity
CBW65_05635	COG0604	alcohol dehydrogenase
CBW65_05640	COG3829	transcription factor binding
CBW65_05655	COG3227	Zinc metalloprotease (Elastase)
CBW65_05665	COG3227	Zinc metalloprotease (Elastase)
CBW65_05675	COG3227	Zinc metalloprotease (Elastase)
CBW65_05725	COG1937	Protein conserved in bacteria
CBW65_05745	COG0010	Belongs to the arginase family
CBW65_05755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBW65_05780	COG0840	transmembrane signaling receptor activity
CBW65_05805	COG0697	spore germination
CBW65_05815	COG2363	Small membrane protein
CBW65_05820	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CBW65_05835	COG1132	(ABC) transporter
CBW65_05840	COG1132	(ABC) transporter
CBW65_05845	COG0456	acetyltransferase
CBW65_05850	COG3153	acetyltransferase
CBW65_05850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_05855	COG0656	L-ascorbic acid biosynthetic process
CBW65_05860	COG2814	Major facilitator Superfamily
CBW65_05865	COG1733	regulation of RNA biosynthetic process
CBW65_05875	COG2814	Major facilitator Superfamily
CBW65_05890	COG1598	PFAM Uncharacterised protein family UPF0150
CBW65_05895	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CBW65_05900	COG1984	allophanate hydrolase subunit 2
CBW65_05905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CBW65_05940	COG0515	serine threonine protein kinase
CBW65_05945	COG1253	flavin adenine dinucleotide binding
CBW65_05975	COG2814	Major facilitator Superfamily
CBW65_05985	COG5002	protein histidine kinase activity
CBW65_05990	COG0154	amidase activity
CBW65_05995	COG0861	Integral membrane protein TerC family
CBW65_06010	COG0813	purine-nucleoside phosphorylase activity
CBW65_06020	COG0423	glycine-tRNA ligase activity
CBW65_06030	COG1113	amino acid transport
CBW65_06045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_06055	COG0656	L-ascorbic acid biosynthetic process
CBW65_06130	COG0492	ferredoxin-NADP+ reductase activity
CBW65_06135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_06150	COG1643	Atp-dependent helicase
CBW65_06155	COG1214	PFAM Peptidase M22, glycoprotease
CBW65_06155	COG0456	acetyltransferase
CBW65_06160	COG0488	(ABC) transporter
CBW65_06165	COG4895	conserved protein (DUF2196)
CBW65_06175	COG2814	Major facilitator Superfamily
CBW65_06180	COG1187	pseudouridine synthase activity
CBW65_06195	COG0167	dihydroorotate dehydrogenase activity
CBW65_06230	COG3290	protein histidine kinase activity
CBW65_06235	COG4565	transcriptional regulatory protein
CBW65_06285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBW65_06285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBW65_06305	COG0783	Belongs to the Dps family
CBW65_06310	COG0789	Transcriptional regulator
CBW65_06315	COG1902	pentaerythritol trinitrate reductase activity
CBW65_06350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_06360	COG3832	glyoxalase III activity
CBW65_06365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CBW65_06370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CBW65_06380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CBW65_06405	COG4335	DNA alkylation repair
CBW65_06425	COG4191	Histidine kinase
CBW65_06435	COG2824	Alkylphosphonate utilization operon protein PhnA
CBW65_06440	COG2207	Transcriptional regulator
CBW65_06440	COG3708	Transcriptional regulator
CBW65_06455	COG0084	hydrolase, TatD family'
CBW65_06475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CBW65_06485	COG3655	Transcriptional regulator
CBW65_06495	COG0583	DNA-binding transcription factor activity
CBW65_06500	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_06510	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CBW65_06530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CBW65_06550	COG0217	transcriptional regulatory protein
CBW65_06555	COG2264	protein methyltransferase activity
CBW65_06580	COG1484	DNA-dependent DNA replication
CBW65_06595	COG1136	(ABC) transporter
CBW65_06600	COG0577	efflux transmembrane transporter activity
CBW65_06610	COG3655	Transcriptional regulator
CBW65_06645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CBW65_06655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_06665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CBW65_06675	COG4863	YycH protein
CBW65_06680	COG5002	protein histidine kinase activity
CBW65_06695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CBW65_06700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_06710	COG0305	Participates in initiation and elongation during chromosome replication
CBW65_06715	COG0470	DNA polymerase III
CBW65_06715	COG1067	ATP-dependent peptidase activity
CBW65_06775	COG0644	oxidoreductase
CBW65_06790	COG1131	(ABC) transporter
CBW65_06795	COG1725	Transcriptional regulator
CBW65_06800	COG0726	polysaccharide deacetylase
CBW65_06830	COG2814	Major facilitator Superfamily
CBW65_06835	COG1151	hydroxylamine reductase activity
CBW65_06845	COG0488	(ABC) transporter
CBW65_06855	COG1309	transcriptional regulator
CBW65_06860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CBW65_06870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CBW65_06875	COG1714	RDD family
CBW65_06885	COG1595	DNA-templated transcription, initiation
CBW65_06920	COG0251	oxidation-reduction process
CBW65_06925	COG2814	Major facilitator Superfamily
CBW65_06945	COG4941	Belongs to the sigma-70 factor family
CBW65_06975	COG4974	Belongs to the 'phage' integrase family
CBW65_06985	COG3436	PFAM IS66 Orf2 family protein
CBW65_06990	COG4372	Transposase
CBW65_07010	COG0629	single-stranded DNA binding
CBW65_07015	COG0360	Binds together with S18 to 16S ribosomal RNA
CBW65_07020	COG0012	GTP binding
CBW65_07045	COG0243	molybdopterin cofactor binding
CBW65_07050	COG4481	Protein conserved in bacteria
CBW65_07055	COG0668	transmembrane transport
CBW65_07095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CBW65_07100	COG1475	DNA binding
CBW65_07105	COG1192	Involved in chromosome partitioning
CBW65_07110	COG1475	DNA binding
CBW65_07115	COG0357	Ribosomal RNA small subunit methyltransferase G
CBW65_07120	COG0445	tRNA wobble uridine modification
CBW65_07125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CBW65_07130	COG1847	R3H domain protein
CBW65_07140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CBW65_07150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CBW65_07165	COG0592	DNA-directed DNA polymerase activity
CBW65_07170	COG2501	S4 domain
CBW65_07175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_07185	COG0187	DNA topoisomerase II activity
CBW65_07190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CBW65_07200	COG3220	belongs to the UPF0276 family
CBW65_07245	COG0517	IMP dehydrogenase activity
CBW65_07245	COG0516	GMP reductase activity
CBW65_07250	COG1686	Belongs to the peptidase S11 family
CBW65_07260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CBW65_07275	COG1428	Deoxynucleoside kinase
CBW65_07280	COG1428	Deoxynucleoside kinase
CBW65_07300	COG0590	tRNA wobble adenosine to inosine editing
CBW65_07315	COG3852	Histidine kinase
CBW65_07320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CBW65_07325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CBW65_07330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CBW65_07425	COG4372	Transposase
CBW65_07430	COG3436	PFAM IS66 Orf2 family protein
CBW65_07495	COG1982	Orn Lys Arg decarboxylase major
CBW65_07500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CBW65_07505	COG3870	Protein conserved in bacteria
CBW65_07510	COG1728	Protein conserved in bacteria
CBW65_07515	COG0470	DNA polymerase III
CBW65_07520	COG1774	PSP1 C-terminal conserved region
CBW65_07525	COG4467	Involved in initiation control of chromosome replication
CBW65_07565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CBW65_07570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CBW65_07575	COG2002	toxin-antitoxin pair type II binding
CBW65_07585	COG0084	hydrolase, TatD family'
CBW65_07595	COG0772	Belongs to the SEDS family
CBW65_07600	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CBW65_07605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CBW65_07610	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CBW65_07635	COG0697	spore germination
CBW65_07655	COG4466	Protein conserved in bacteria
CBW65_07675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CBW65_07685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBW65_07690	COG0251	oxidation-reduction process
CBW65_07695	COG2088	sporulation resulting in formation of a cellular spore
CBW65_07700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CBW65_07705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CBW65_07720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CBW65_07725	COG0193	aminoacyl-tRNA hydrolase activity
CBW65_07735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CBW65_07745	COG2002	toxin-antitoxin pair type II binding
CBW65_07750	COG2244	polysaccharide biosynthetic process
CBW65_07755	COG3956	TIGRFAM MazG family protein
CBW65_07765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CBW65_07785	COG1098	S1 RNA binding domain
CBW65_07795	COG3343	RNA polymerase activity
CBW65_07800	COG0504	CTP synthase activity
CBW65_07840	COG3764	Sortase (surface protein transpeptidase)
CBW65_07845	COG0737	Belongs to the 5'-nucleotidase family
CBW65_07850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBW65_07860	COG1131	(ABC) transporter
CBW65_07875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CBW65_07885	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CBW65_07890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBW65_07895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CBW65_07900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CBW65_07905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CBW65_07915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CBW65_08070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CBW65_08080	COG4555	ABC transporter
CBW65_08085	COG1668	transmembrane transport
CBW65_08150	COG1309	transcriptional regulator
CBW65_08155	COG0546	phosphoglycolate phosphatase activity
CBW65_08165	COG3880	PFAM UvrB UvrC protein
CBW65_08170	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CBW65_08175	COG0542	response to heat
CBW65_08180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CBW65_08185	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CBW65_08190	COG1183	phosphatidylcholine synthase activity
CBW65_08195	COG4956	integral membrane protein (PIN domain superfamily)
CBW65_08200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CBW65_08205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CBW65_08210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CBW65_08215	COG1045	serine acetyltransferase
CBW65_08220	COG0215	cysteine-tRNA ligase activity
CBW65_08225	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CBW65_08230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBW65_08235	COG3688	RNA-binding protein containing a PIN domain
CBW65_08245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CBW65_08250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CBW65_08255	COG0250	Participates in transcription elongation, termination and antitermination
CBW65_08260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CBW65_08265	COG0081	regulation of translation
CBW65_08280	COG2813	Specifically methylates the guanine in position
CBW65_08285	COG0085	RNA polymerase activity
CBW65_08290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CBW65_08295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CBW65_08300	COG0049	tRNA binding
CBW65_08305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBW65_08310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CBW65_08315	COG0051	transcription antitermination factor activity, RNA binding
CBW65_08320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CBW65_08325	COG0088	Forms part of the polypeptide exit tunnel
CBW65_08330	COG0089	rRNA binding
CBW65_08335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CBW65_08340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CBW65_08350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CBW65_08355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CBW65_08360	COG0255	Belongs to the universal ribosomal protein uL29 family
CBW65_08365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CBW65_08370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CBW65_08375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CBW65_08380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CBW65_08390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CBW65_08395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CBW65_08400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CBW65_08405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CBW65_08410	COG1841	ribosomal large subunit assembly
CBW65_08415	COG0200	Binds to the 23S rRNA
CBW65_08420	COG0201	protein transport
CBW65_08425	COG0563	adenylate kinase activity
CBW65_08430	COG0024	Methionine aminopeptidase
CBW65_08440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CBW65_08445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CBW65_08450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CBW65_08455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CBW65_08460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBW65_08465	COG0202	RNA polymerase activity
CBW65_08470	COG0203	ribosomal protein L17
CBW65_08475	COG0101	tRNA pseudouridine synthase activity
CBW65_08480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CBW65_08485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CBW65_08490	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_08500	COG0489	protein tyrosine kinase activity
CBW65_08515	COG0726	polysaccharide deacetylase
CBW65_08570	COG0653	protein targeting
CBW65_08575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CBW65_08805	COG2720	vancomycin resistance protein
CBW65_08820	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CBW65_08825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CBW65_08830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBW65_08835	COG1612	heme a metabolic process
CBW65_08855	COG0028	Belongs to the TPP enzyme family
CBW65_08870	COG2814	Major facilitator Superfamily
CBW65_08875	COG0488	(ABC) transporter
CBW65_08880	COG0671	phosphoesterase, PA-phosphatase related
CBW65_08945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CBW65_08950	COG3693	PFAM glycoside hydrolase, family 10
CBW65_08955	COG0745	RESPONSE REGULATOR receiver
CBW65_08955	COG3706	GGDEF domain
CBW65_08960	COG0746	molybdenum cofactor guanylyltransferase activity
CBW65_08975	COG0303	'Molybdopterin
CBW65_08980	COG1763	Mo-molybdopterin cofactor biosynthetic process
CBW65_08985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBW65_08990	COG0805	protein transport
CBW65_09000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CBW65_09005	COG0459	protein refolding
CBW65_09010	COG4942	peptidase
CBW65_09015	COG0714	Associated with various cellular activities
CBW65_09025	COG1305	Transglutaminase-like
CBW65_09030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CBW65_09030	COG0519	Catalyzes the synthesis of GMP from XMP
CBW65_09035	COG2252	PERMEase
CBW65_09050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CBW65_09055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CBW65_09060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CBW65_09065	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CBW65_09070	COG0047	phosphoribosylformylglycinamidine synthase activity
CBW65_09075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CBW65_09080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CBW65_09085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CBW65_09090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CBW65_09100	COG0151	Belongs to the GarS family
CBW65_09120	COG0861	Integral membrane protein TerC family
CBW65_09130	COG2319	Wd-40 repeat
CBW65_09135	COG2814	Major facilitator Superfamily
CBW65_09145	COG1408	metallophosphoesterase
CBW65_09160	COG0583	DNA-binding transcription factor activity
CBW65_09175	COG0681	Belongs to the peptidase S26 family
CBW65_09180	COG0681	Belongs to the peptidase S26 family
CBW65_09185	COG1595	DNA-templated transcription, initiation
CBW65_09190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CBW65_09195	COG5002	protein histidine kinase activity
CBW65_09195	COG3850	Histidine kinase
CBW65_09200	COG0745	RESPONSE REGULATOR receiver
CBW65_09210	COG1073	alpha beta
CBW65_09225	COG1595	DNA-templated transcription, initiation
CBW65_09250	COG0438	transferase activity, transferring glycosyl groups
CBW65_09265	COG0438	transferase activity, transferring glycosyl groups
CBW65_09270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CBW65_09280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CBW65_09285	COG1086	Polysaccharide biosynthesis protein
CBW65_09300	COG0166	Belongs to the GPI family
CBW65_09360	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_09390	COG1192	Involved in chromosome partitioning
CBW65_09460	COG0180	Tryptophanyl-tRNA synthetase
CBW65_09565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_09570	COG3885	ferrous iron binding
CBW65_09570	COG2078	PFAM AMMECR1 domain protein
CBW65_09630	COG0477	Major facilitator Superfamily
CBW65_09670	COG1024	Enoyl-CoA hydratase
CBW65_09685	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_09690	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_09695	COG0183	Belongs to the thiolase family
CBW65_09700	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_09740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CBW65_09770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CBW65_09775	COG1971	Probably functions as a manganese efflux pump
CBW65_09780	COG0861	Integral membrane protein TerC family
CBW65_09785	COG2267	carboxylic ester hydrolase activity
CBW65_09790	COG0316	Belongs to the HesB IscA family
CBW65_09800	COG1131	(ABC) transporter
CBW65_09815	COG1131	(ABC) transporter
CBW65_09820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CBW65_09840	COG2050	protein possibly involved in aromatic compounds catabolism
CBW65_09845	COG0736	holo-[acyl-carrier-protein] synthase activity
CBW65_09850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CBW65_09855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CBW65_09860	COG0864	Transcriptional regulator
CBW65_09865	COG2337	Toxic component of a toxin-antitoxin (TA) module
CBW65_09875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBW65_09880	COG2205	protein histidine kinase activity
CBW65_09890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CBW65_09895	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CBW65_09975	COG2814	Major facilitator Superfamily
CBW65_10040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CBW65_10055	COG4585	Histidine kinase
CBW65_10060	COG2197	response regulator
CBW65_10070	COG0735	belongs to the Fur family
CBW65_10095	COG5002	protein histidine kinase activity
CBW65_10100	COG1111	helicase
CBW65_10100	COG1205	dead DEAH box helicase
CBW65_10115	COG1846	Transcriptional regulator
CBW65_10120	COG2814	Major facilitator Superfamily
CBW65_10125	COG3273	potassium ion transport
CBW65_10125	COG0471	metal ion transport
CBW65_10155	COG3359	exonuclease
CBW65_10160	COG3706	GGDEF domain
CBW65_10165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CBW65_10170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CBW65_10175	COG1473	amidohydrolase
CBW65_10220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CBW65_10225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CBW65_10230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBW65_10235	COG0671	phosphoesterase, PA-phosphatase related
CBW65_10250	COG2183	response to ionizing radiation
CBW65_10275	COG2720	vancomycin resistance protein
CBW65_10300	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CBW65_10320	COG2808	Putative FMN-binding domain
CBW65_10330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CBW65_10335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CBW65_10340	COG0802	atpase or kinase
CBW65_10345	COG1214	PFAM Peptidase M22, glycoprotease
CBW65_10350	COG0456	acetyltransferase
CBW65_10355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CBW65_10365	COG1247	-acetyltransferase
CBW65_10370	COG0640	Transcriptional regulator
CBW65_10375	COG0346	lactoylglutathione lyase activity
CBW65_10385	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_10410	COG5001	Diguanylate cyclase
CBW65_10410	COG3300	MHYT domain
CBW65_10480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_10485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CBW65_10490	COG0137	argininosuccinate synthase activity
CBW65_10495	COG0165	Argininosuccinate lyase
CBW65_10510	COG1136	(ABC) transporter
CBW65_10515	COG0577	efflux transmembrane transporter activity
CBW65_10525	COG0803	Belongs to the bacterial solute-binding protein 9 family
CBW65_10530	COG1121	(ABC) transporter
CBW65_10535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBW65_10540	COG2884	Cell division ATP-binding protein ftsE
CBW65_10545	COG2177	Part of the ABC transporter FtsEX involved in
CBW65_10550	COG0741	lytic transglycosylase activity
CBW65_10550	COG0739	heme binding
CBW65_10550	COG1196	nuclear chromosome segregation
CBW65_10555	COG3409	Peptidoglycan-binding domain 1 protein
CBW65_10555	COG0793	Belongs to the peptidase S41A family
CBW65_10565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CBW65_10570	COG1360	Flagellar Motor Protein
CBW65_10575	COG0556	nucleotide-excision repair
CBW65_10585	COG1106	Psort location Cytoplasmic, score
CBW65_10600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CBW65_10615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CBW65_10625	COG0741	lytic transglycosylase activity
CBW65_10625	COG0739	heme binding
CBW65_10625	COG1196	nuclear chromosome segregation
CBW65_10630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBW65_10635	COG0546	phosphoglycolate phosphatase activity
CBW65_10640	COG0110	maltose O-acetyltransferase activity
CBW65_10645	COG0439	Biotin carboxylase
CBW65_10655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_10660	COG1509	lysine 2,3-aminomutase activity
CBW65_10665	COG0124	histidyl-tRNA synthetase
CBW65_10670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CBW65_10675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CBW65_10680	COG0131	Imidazoleglycerol-phosphate dehydratase
CBW65_10685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CBW65_10690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CBW65_10700	COG0140	phosphoribosyl-ATP diphosphatase activity
CBW65_10700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CBW65_10710	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_10735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CBW65_10770	COG0697	spore germination
CBW65_10780	COG0386	Belongs to the glutathione peroxidase family
CBW65_10785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBW65_10790	COG0601	transmembrane transport
CBW65_10795	COG4166	transmembrane transport
CBW65_10810	COG1592	Rubrerythrin
CBW65_10815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CBW65_10820	COG0457	Tetratricopeptide repeat
CBW65_10825	COG0492	ferredoxin-NADP+ reductase activity
CBW65_10835	COG1051	belongs to the nudix hydrolase family
CBW65_10840	COG0840	transmembrane signaling receptor activity
CBW65_10845	COG1660	Displays ATPase and GTPase activities
CBW65_10850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CBW65_10855	COG1481	regulation of sporulation
CBW65_10860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBW65_10885	COG1573	uracil-dna glycosylase
CBW65_10890	COG1368	sulfuric ester hydrolase activity
CBW65_10910	COG1368	sulfuric ester hydrolase activity
CBW65_10915	COG3300	MHYT domain
CBW65_10915	COG5001	Diguanylate cyclase
CBW65_10945	COG0351	phosphomethylpyrimidine kinase
CBW65_10950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CBW65_10955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CBW65_10960	COG2390	Transcriptional regulator
CBW65_10970	COG0126	phosphoglycerate kinase activity
CBW65_10975	COG0149	triose-phosphate isomerase activity
CBW65_10980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CBW65_10985	COG0148	phosphopyruvate hydratase activity
CBW65_10990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CBW65_11000	COG0557	exoribonuclease II activity
CBW65_11020	COG1090	epimerase
CBW65_11025	COG1842	Phage shock protein A
CBW65_11040	COG1278	Cold shock
CBW65_11050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_11060	COG2135	peptidase activity
CBW65_11075	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CBW65_11080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CBW65_11135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBW65_11145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CBW65_11150	COG0406	alpha-ribazole phosphatase activity
CBW65_11155	COG1492	cobalamin metabolic process
CBW65_11180	COG2078	PFAM AMMECR1 domain protein
CBW65_11180	COG3885	ferrous iron binding
CBW65_11190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBW65_11195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBW65_11200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBW65_11245	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CBW65_11260	COG1074	ATP-dependent DNA helicase activity
CBW65_11300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_11345	COG4372	Transposase
CBW65_11365	COG0019	diaminopimelate decarboxylase activity
CBW65_11375	COG4264	IucA IucC family
CBW65_11380	COG4264	IucA IucC family
CBW65_11390	COG2423	ornithine cyclodeaminase activity
CBW65_11400	COG4264	IucA IucC family
CBW65_11405	COG2814	Major facilitator Superfamily
CBW65_11410	COG4264	IucA IucC family
CBW65_11415	COG0019	diaminopimelate decarboxylase activity
CBW65_11425	COG1309	transcriptional regulator
CBW65_11460	COG3620	sequence-specific DNA binding
CBW65_11465	COG1476	TRANSCRIPTIONal
CBW65_11470	COG0436	Aminotransferase
CBW65_11480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_11485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CBW65_11505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CBW65_11505	COG2080	2 iron, 2 sulfur cluster binding
CBW65_11520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CBW65_11525	COG0746	molybdenum cofactor guanylyltransferase activity
CBW65_11535	COG3186	Phenylalanine-4-hydroxylase
CBW65_11550	COG0116	Belongs to the methyltransferase superfamily
CBW65_11560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CBW65_11575	COG1132	(ABC) transporter
CBW65_11580	COG1132	(ABC) transporter
CBW65_11620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBW65_11625	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBW65_11655	COG4721	ABC-type cobalt transport system, permease component
CBW65_11660	COG1122	ATPase activity
CBW65_11665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CBW65_11670	COG2205	protein histidine kinase activity
CBW65_11675	COG2205	protein histidine kinase activity
CBW65_11690	COG1309	transcriptional regulator
CBW65_11700	COG1242	4 iron, 4 sulfur cluster binding
CBW65_11705	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CBW65_11710	COG1595	DNA-templated transcription, initiation
CBW65_11730	COG1074	ATP-dependent DNA helicase activity
CBW65_11745	COG2357	RelA SpoT domain protein
CBW65_11760	COG0396	ATPase activity
CBW65_11765	COG0719	Fe-S assembly protein
CBW65_11770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CBW65_11775	COG0822	iron-sulfur transferase activity
CBW65_11780	COG0719	Fe-S assembly protein
CBW65_11785	COG0840	transmembrane signaling receptor activity
CBW65_11790	COG0840	transmembrane signaling receptor activity
CBW65_11795	COG0475	glutathione-regulated potassium exporter activity
CBW65_11810	COG1309	transcriptional regulator
CBW65_11815	COG2086	electron transfer activity
CBW65_11820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBW65_11860	COG0124	histidyl-tRNA synthetase
CBW65_11880	COG2264	protein methyltransferase activity
CBW65_11895	COG2814	Major facilitator Superfamily
CBW65_11905	COG3402	PFAM membrane-flanked domain
CBW65_11910	COG3428	Bacterial PH domain
CBW65_11915	COG0372	Belongs to the citrate synthase family
CBW65_11920	COG0583	DNA-binding transcription factor activity
CBW65_11930	COG0564	pseudouridine synthase activity
CBW65_11940	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CBW65_11945	COG0179	Fumarylacetoacetate (FAA) hydrolase
CBW65_11950	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CBW65_11955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CBW65_12020	COG0537	adenosine 5'-monophosphoramidase activity
CBW65_12060	COG4372	Transposase
CBW65_12065	COG3436	PFAM IS66 Orf2 family protein
CBW65_12110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBW65_12125	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CBW65_12135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CBW65_12150	COG3436	PFAM IS66 Orf2 family protein
CBW65_12155	COG4372	Transposase
CBW65_12180	COG1363	Peptidase, m42
CBW65_12230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CBW65_12235	COG4166	transmembrane transport
CBW65_12250	COG5002	protein histidine kinase activity
CBW65_12260	COG3842	ATPase activity
CBW65_12265	COG1098	S1 RNA binding domain
CBW65_12285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CBW65_12310	COG3584	3D domain protein
CBW65_12310	COG3583	domain protein
CBW65_12315	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_12315	COG1024	Enoyl-CoA hydratase
CBW65_12320	COG0183	Belongs to the thiolase family
CBW65_12325	COG1960	acyl-CoA dehydrogenase activity
CBW65_12330	COG1122	ATPase activity
CBW65_12335	COG1122	ATPase activity
CBW65_12340	COG1268	BioY protein
CBW65_12350	COG0671	phosphoesterase, PA-phosphatase related
CBW65_12355	COG1575	Belongs to the MenA family. Type 1 subfamily
CBW65_12365	COG1070	Carbohydrate kinase
CBW65_12375	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CBW65_12400	COG3875	lactate racemase activity
CBW65_12405	COG1703	isobutyryl-CoA mutase activity
CBW65_12405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_12405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_12430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBW65_12435	COG2222	sugar isomerase
CBW65_12440	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_12445	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_12450	COG2172	sigma factor antagonist activity
CBW65_12460	COG0531	amino acid
CBW65_12480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBW65_12485	COG0583	DNA-binding transcription factor activity
CBW65_12490	COG2340	Cysteine-rich secretory protein family
CBW65_12500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CBW65_12505	COG1252	NADH dehydrogenase
CBW65_12525	COG0612	Peptidase, M16
CBW65_12530	COG0612	Peptidase, M16
CBW65_12540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_12545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_12600	COG1337	RAMP superfamily
CBW65_12630	COG3209	COG3209 Rhs family protein
CBW65_12640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CBW65_12645	COG0602	queuosine metabolic process
CBW65_12650	COG0720	synthase
CBW65_12655	COG4974	Belongs to the 'phage' integrase family
CBW65_12665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CBW65_12675	COG1956	GAF domain-containing protein
CBW65_12690	COG1213	nucleotidyl transferase
CBW65_12700	COG0426	domain, Protein
CBW65_12705	COG0772	Belongs to the SEDS family
CBW65_12710	COG5002	protein histidine kinase activity
CBW65_12720	COG2814	Major facilitator Superfamily
CBW65_12735	COG0584	glycerophosphoryl diester phosphodiesterase
CBW65_12740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBW65_12750	COG1595	DNA-templated transcription, initiation
CBW65_12760	COG2814	Major facilitator Superfamily
CBW65_12765	COG0785	Cytochrome C biogenesis protein
CBW65_12770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_12780	COG0745	RESPONSE REGULATOR receiver
CBW65_12785	COG5002	protein histidine kinase activity
CBW65_12790	COG2132	Multicopper oxidase
CBW65_12800	COG0640	Transcriptional regulator
CBW65_12820	COG0436	Aminotransferase
CBW65_12825	COG1850	ribulose-bisphosphate carboxylase activity
CBW65_12830	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CBW65_12835	COG0235	Class ii aldolase
CBW65_12840	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CBW65_12910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CBW65_12930	COG0583	DNA-binding transcription factor activity
CBW65_12945	COG3340	Belongs to the peptidase S51 family
CBW65_12950	COG0346	lactoylglutathione lyase activity
CBW65_12960	COG1607	acyl-coa hydrolase
CBW65_12965	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CBW65_12990	COG5002	protein histidine kinase activity
CBW65_12995	COG0561	phosphatase activity
CBW65_13005	COG3290	protein histidine kinase activity
CBW65_13005	COG3829	transcription factor binding
CBW65_13045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CBW65_13050	COG1294	oxidase, subunit
CBW65_13055	COG1271	oxidase subunit
CBW65_13070	COG3546	catalase activity
CBW65_13085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CBW65_13095	COG0791	NLP P60 protein
CBW65_13100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBW65_13135	COG2270	Major facilitator Superfamily
CBW65_13145	COG1164	Oligoendopeptidase f
CBW65_13150	COG3852	Histidine kinase
CBW65_13160	COG1022	Amp-dependent synthetase and ligase
CBW65_13180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_13190	COG0006	proline dipeptidase activity
CBW65_13195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CBW65_13200	COG2357	RelA SpoT domain protein
CBW65_13215	COG1832	CoA-binding protein
CBW65_13220	COG1393	Belongs to the ArsC family
CBW65_13225	COG0612	Peptidase, M16
CBW65_13230	COG0697	spore germination
CBW65_13235	COG1368	sulfuric ester hydrolase activity
CBW65_13250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBW65_13255	COG0765	amino acid transport
CBW65_13260	COG1126	abc transporter atp-binding protein
CBW65_13290	COG2814	Major facilitator Superfamily
CBW65_13305	COG1982	Orn Lys Arg decarboxylase major
CBW65_13310	COG1388	LysM domain
CBW65_13310	COG3584	3D domain protein
CBW65_13315	COG0297	glycogen (starch) synthase activity
CBW65_13325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CBW65_13325	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBW65_13330	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBW65_13350	COG0583	DNA-binding transcription factor activity
CBW65_13355	COG2211	Major facilitator Superfamily
CBW65_13370	COG0628	permease
CBW65_13375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CBW65_13385	COG1078	dGTPase activity
CBW65_13390	COG0561	phosphatase activity
CBW65_13395	COG0840	transmembrane signaling receptor activity
CBW65_13410	COG3639	organic phosphonate transmembrane transporter activity
CBW65_13415	COG3639	organic phosphonate transmembrane transporter activity
CBW65_13430	COG0586	Pfam SNARE associated Golgi protein
CBW65_13445	COG3377	Domain of unknown function (DUF1805)
CBW65_13460	COG1396	sequence-specific DNA binding
CBW65_13470	COG1363	Peptidase, m42
CBW65_13475	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CBW65_13495	COG2843	Capsule synthesis protein
CBW65_13505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_13525	COG0494	nUDIX hydrolase
CBW65_13550	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBW65_13555	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBW65_13555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CBW65_13560	COG1725	Transcriptional regulator
CBW65_13565	COG0584	glycerophosphoryl diester phosphodiesterase
CBW65_13570	COG5577	PFAM Coat F domain
CBW65_13585	COG0513	Belongs to the DEAD box helicase family
CBW65_13595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CBW65_13610	COG1131	(ABC) transporter
CBW65_13625	COG3584	3D domain protein
CBW65_13635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CBW65_13635	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBW65_13640	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBW65_13745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CBW65_13830	COG4974	Belongs to the 'phage' integrase family
CBW65_13890	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBW65_13895	COG0189	ligase activity
CBW65_13920	COG2096	Adenosyltransferase
CBW65_13925	COG0647	UMP catabolic process
CBW65_13935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_13940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CBW65_13980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_13980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_14000	COG0640	Transcriptional regulator
CBW65_14015	COG4294	response to UV
CBW65_14020	COG1252	NADH dehydrogenase
CBW65_14025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBW65_14030	COG1466	dna polymerase III delta subunit
CBW65_14040	COG0268	Binds directly to 16S ribosomal RNA
CBW65_14055	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_14070	COG1522	sequence-specific DNA binding
CBW65_14075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_14080	COG0481	GTPase activity
CBW65_14090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_14105	COG1420	regulation of RNA biosynthetic process
CBW65_14110	COG0459	protein refolding
CBW65_14120	COG0443	Heat shock 70 kDa protein
CBW65_14130	COG2264	protein methyltransferase activity
CBW65_14135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CBW65_14140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBW65_14145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CBW65_14150	COG1283	sodium-dependent phosphate transmembrane transporter activity
CBW65_14155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CBW65_14160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CBW65_14165	COG1610	YqeY-like protein
CBW65_14170	COG1030	water channel activity
CBW65_14175	COG4864	UPF0365 protein
CBW65_14195	COG1702	phosphate starvation-inducible protein PhoH
CBW65_14200	COG1480	7TM receptor with intracellular HD hydrolase
CBW65_14205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CBW65_14210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CBW65_14220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CBW65_14230	COG1381	Involved in DNA repair and RecF pathway recombination
CBW65_14270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CBW65_14280	COG0517	IMP dehydrogenase activity
CBW65_14285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CBW65_14290	COG0574	Belongs to the PEP-utilizing enzyme family
CBW65_14290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBW65_14295	COG0358	DNA primase activity
CBW65_14300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CBW65_14310	COG1960	acyl-CoA dehydrogenase activity
CBW65_14320	COG0583	DNA-binding transcription factor activity
CBW65_14335	COG0583	DNA-binding transcription factor activity
CBW65_14340	COG2384	SAM-dependent methyltransferase
CBW65_14345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CBW65_14360	COG1272	protein, Hemolysin III
CBW65_14370	COG2169	Transcriptional regulator
CBW65_14380	COG0367	asparagine synthase
CBW65_14390	COG2329	Antibiotic biosynthesis monooxygenase
CBW65_14395	COG3291	Pkd domain containing protein
CBW65_14395	COG4412	M6 family metalloprotease domain protein
CBW65_14400	COG3291	Pkd domain containing protein
CBW65_14400	COG4412	M6 family metalloprotease domain protein
CBW65_14420	COG2268	Band 7 protein
CBW65_14425	COG1215	transferase activity, transferring glycosyl groups
CBW65_14445	COG0546	phosphoglycolate phosphatase activity
CBW65_14460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CBW65_14465	COG0561	phosphatase activity
CBW65_14475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CBW65_14480	COG1131	(ABC) transporter
CBW65_14485	COG2755	lipolytic protein G-D-S-L family
CBW65_14490	COG2323	membrane
CBW65_14495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CBW65_14500	COG0826	peptidase U32
CBW65_14510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CBW65_14510	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CBW65_14520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CBW65_14525	COG0512	Glutamine amidotransferase of anthranilate synthase
CBW65_14530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBW65_14600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CBW65_14630	COG4974	Belongs to the 'phage' integrase family
CBW65_14655	COG0582	viral genome integration into host DNA
CBW65_14695	COG3800	Transcriptional regulator
CBW65_14695	COG1396	sequence-specific DNA binding
CBW65_14745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBW65_14755	COG0745	RESPONSE REGULATOR receiver
CBW65_14775	COG3714	YhhN family
CBW65_14785	COG0583	DNA-binding transcription factor activity
CBW65_14805	COG2962	Rard protein
CBW65_14825	COG1132	(ABC) transporter
CBW65_14830	COG1132	(ABC) transporter
CBW65_14840	COG1285	pathogenesis
CBW65_14865	COG3279	Response regulator of the LytR AlgR family
CBW65_14870	COG0427	acetyl-CoA hydrolase
CBW65_14875	COG0726	polysaccharide deacetylase
CBW65_14900	COG0840	transmembrane signaling receptor activity
CBW65_14905	COG0583	DNA-binding transcription factor activity
CBW65_14910	COG0697	spore germination
CBW65_14940	COG2746	aminoglycoside 3-N-acetyltransferase activity
CBW65_14970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CBW65_15005	COG1073	alpha beta
CBW65_15010	COG0512	Glutamine amidotransferase of anthranilate synthase
CBW65_15020	COG1376	ErfK ybiS ycfS ynhG family protein
CBW65_15040	COG3442	glutamine amidotransferase
CBW65_15045	COG2814	Major facilitator Superfamily
CBW65_15050	COG2081	HI0933 family
CBW65_15085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CBW65_15105	COG0740	serine-type endopeptidase activity
CBW65_15115	COG1307	EDD domain protein, DegV family
CBW65_15130	COG0301	tRNA thio-modification
CBW65_15140	COG4224	UPF0291 protein
CBW65_15145	COG0454	-acetyltransferase
CBW65_15155	COG1011	Hydrolase
CBW65_15160	COG0515	serine threonine protein kinase
CBW65_15160	COG2815	serine threonine protein kinase
CBW65_15195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBW65_15210	COG2226	methyltransferase
CBW65_15220	COG0697	spore germination
CBW65_15225	COG0814	amino acid
CBW65_15245	COG1671	Belongs to the UPF0178 family
CBW65_15250	COG3854	ATPases associated with a variety of cellular activities
CBW65_15290	COG0511	ligase activity, forming carbon-carbon bonds
CBW65_15295	COG0439	Biotin carboxylase
CBW65_15300	COG1302	Protein conserved in bacteria
CBW65_15315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBW65_15320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CBW65_15330	COG1570	exodeoxyribonuclease VII activity
CBW65_15335	COG1722	exodeoxyribonuclease VII activity
CBW65_15345	COG2323	membrane
CBW65_15350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CBW65_15355	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CBW65_15360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CBW65_15365	COG1438	arginine binding
CBW65_15370	COG0497	DNA recombination
CBW65_15375	COG0750	zinc metalloprotease
CBW65_15415	COG1595	DNA-templated transcription, initiation
CBW65_15445	COG4166	transmembrane transport
CBW65_15455	COG4166	transmembrane transport
CBW65_15470	COG2203	Gaf domain
CBW65_15470	COG2199	diguanylate cyclase activity
CBW65_15475	COG2267	carboxylic ester hydrolase activity
CBW65_15500	COG2086	electron transfer activity
CBW65_15505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBW65_15510	COG0644	oxidoreductase
CBW65_15520	COG2153	protein acetylation
CBW65_15525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBW65_15530	COG0488	(ABC) transporter
CBW65_15535	COG0725	ABC transporter, periplasmic molybdate-binding protein
CBW65_15540	COG4149	molybdate abc transporter
CBW65_15565	COG0316	Belongs to the HesB IscA family
CBW65_15570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CBW65_15575	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_15580	COG2267	carboxylic ester hydrolase activity
CBW65_15590	COG0439	Biotin carboxylase
CBW65_15595	COG0511	ligase activity, forming carbon-carbon bonds
CBW65_15600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CBW65_15605	COG1024	Enoyl-CoA hydratase
CBW65_15610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CBW65_15615	COG4166	transmembrane transport
CBW65_15620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CBW65_15635	COG1733	regulation of RNA biosynthetic process
CBW65_15640	COG1902	pentaerythritol trinitrate reductase activity
CBW65_15645	COG2001	Belongs to the MraZ family
CBW65_15650	COG0275	rRNA processing
CBW65_15660	COG0768	penicillin binding
CBW65_15675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CBW65_15680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBW65_15685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CBW65_15690	COG0772	Belongs to the SEDS family
CBW65_15700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CBW65_15715	COG3879	Bacterial protein of unknown function (DUF881)
CBW65_15720	COG3856	small basic protein
CBW65_15725	COG0849	cell division
CBW65_15730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CBW65_15865	COG4974	Belongs to the 'phage' integrase family
CBW65_15880	COG1484	DNA-dependent DNA replication
CBW65_15940	COG0644	oxidoreductase
CBW65_15970	COG1191	sigma factor activity
CBW65_15975	COG1191	sigma factor activity
CBW65_15980	COG1873	PFAM PRC-barrel domain
CBW65_15990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CBW65_15995	COG1799	cell septum assembly
CBW65_16010	COG3599	regulation of cell shape
CBW65_16220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CBW65_16225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBW65_16230	COG0564	pseudouridine synthase activity
CBW65_16235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CBW65_16245	COG0540	Belongs to the ATCase OTCase family
CBW65_16250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CBW65_16260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_16265	COG0543	2 iron, 2 sulfur cluster binding
CBW65_16270	COG0167	dihydroorotate dehydrogenase activity
CBW65_16275	COG0284	orotidine-5'-phosphate decarboxylase activity
CBW65_16280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CBW65_16300	COG2267	carboxylic ester hydrolase activity
CBW65_16305	COG0488	(ABC) transporter
CBW65_16315	COG0840	transmembrane signaling receptor activity
CBW65_16320	COG0697	spore germination
CBW65_16340	COG0277	FAD linked oxidase domain protein
CBW65_16375	COG2382	esterase
CBW65_16385	COG0189	ligase activity
CBW65_16390	COG0297	glycogen (starch) synthase activity
CBW65_16405	COG1131	(ABC) transporter
CBW65_16430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CBW65_16440	COG1561	YicC-like family, N-terminal region
CBW65_16445	COG2052	Domain of unknown function (DUF370)
CBW65_16450	COG0194	GDP metabolic process
CBW65_16460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CBW65_16465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CBW65_16480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CBW65_16480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBW65_16485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CBW65_16490	COG0631	protein serine/threonine phosphatase activity
CBW65_16495	COG0515	serine threonine protein kinase
CBW65_16495	COG2815	serine threonine protein kinase
CBW65_16500	COG1162	GTPase activity
CBW65_16505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CBW65_16515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CBW65_16520	COG1302	Protein conserved in bacteria
CBW65_16525	COG1461	Dihydroxyacetone kinase
CBW65_16530	COG1760	l-serine dehydratase
CBW65_16535	COG1760	l-serine dehydratase
CBW65_16540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CBW65_16565	COG0742	ribosomal rna small subunit methyltransferase
CBW65_16570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CBW65_16575	COG1752	Esterase of the alpha-beta hydrolase superfamily
CBW65_16580	COG3480	Lon protease (S16) C-terminal proteolytic domain
CBW65_16595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CBW65_16605	COG0416	fatty acid biosynthetic process
CBW65_16610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBW65_16615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CBW65_16620	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_16625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBW65_16635	COG0571	ribonuclease III activity
CBW65_16645	COG1196	nuclear chromosome segregation
CBW65_16650	COG0552	protein localization to endoplasmic reticulum
CBW65_16655	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CBW65_16660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CBW65_16665	COG0228	four-way junction DNA binding
CBW65_16670	COG1837	Belongs to the UPF0109 family
CBW65_16685	COG0336	Belongs to the RNA methyltransferase TrmD family
CBW65_16740	COG1376	ErfK ybiS ycfS ynhG family protein
CBW65_16745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CBW65_16755	COG0335	large ribosomal subunit rRNA binding
CBW65_16760	COG0681	Belongs to the peptidase S26 family
CBW65_16770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBW65_16785	COG2257	FlhB HrpN YscU SpaS Family
CBW65_16790	COG0792	nuclease activity
CBW65_16825	COG0606	chelatase, subunit chli
CBW65_16850	COG2814	Major facilitator Superfamily
CBW65_16870	COG0045	succinate-CoA ligase (ADP-forming) activity
CBW65_16875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CBW65_16880	COG0758	DNA mediated transformation
CBW65_16885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CBW65_16890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CBW65_16895	COG4974	Belongs to the 'phage' integrase family
CBW65_16900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CBW65_16910	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CBW65_16915	COG1815	bacterial-type flagellum-dependent cell motility
CBW65_16920	COG1558	bacterial-type flagellum-dependent cell motility
CBW65_16935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBW65_16940	COG1317	bacterial-type flagellum organization
CBW65_16945	COG1157	protein secretion by the type III secretion system
CBW65_16965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CBW65_16975	COG4786	Flagellar basal body rod
CBW65_16990	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBW65_16995	COG1776	CheC inhibitor of MCP methylation
CBW65_16995	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBW65_17000	COG2201	protein-glutamate methylesterase activity
CBW65_17010	COG1338	Plays a role in the flagellum-specific transport system
CBW65_17015	COG1987	bacterial-type flagellum assembly
CBW65_17020	COG1684	flagellar biosynthetic protein fliR
CBW65_17025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CBW65_17030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CBW65_17035	COG1419	protein localization to endoplasmic reticulum
CBW65_17040	COG0455	bacterial-type flagellum organization
CBW65_17045	COG2201	protein-glutamate methylesterase activity
CBW65_17050	COG2198	Histidine kinase
CBW65_17050	COG0643	Histidine kinase
CBW65_17055	COG0835	chemotaxis
CBW65_17060	COG1776	CheC inhibitor of MCP methylation
CBW65_17065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CBW65_17075	COG1191	sigma factor activity
CBW65_17100	COG0052	Belongs to the universal ribosomal protein uS2 family
CBW65_17105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CBW65_17110	COG0528	UMP kinase activity
CBW65_17115	COG0233	cytoplasmic translational termination
CBW65_17120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CBW65_17125	COG4589	Belongs to the CDS family
CBW65_17140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CBW65_17145	COG0584	glycerophosphoryl diester phosphodiesterase
CBW65_17150	COG0531	amino acid
CBW65_17165	COG0442	prolyl-tRNA aminoacylation
CBW65_17170	COG0463	Glycosyl transferase, family 2
CBW65_17175	COG2176	DNA-directed DNA polymerase activity
CBW65_17180	COG0779	Required for maturation of 30S ribosomal subunits
CBW65_17185	COG0195	Participates in both transcription termination and antitermination
CBW65_17200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CBW65_17210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CBW65_17215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CBW65_17220	COG0196	riboflavin kinase activity
CBW65_17235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CBW65_17240	COG1185	polyribonucleotide nucleotidyltransferase activity
CBW65_17250	COG0726	polysaccharide deacetylase
CBW65_17255	COG0612	Peptidase, M16
CBW65_17260	COG1873	PFAM PRC-barrel domain
CBW65_17265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBW65_17270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CBW65_17275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CBW65_17280	COG0527	aspartate kinase activity
CBW65_17285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CBW65_17290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CBW65_17295	COG0740	serine-type endopeptidase activity
CBW65_17305	COG4980	gas vesicle protein
CBW65_17305	COG1674	ftsk spoiiie
CBW65_17310	COG2188	Transcriptional regulator
CBW65_17365	COG0477	Major facilitator Superfamily
CBW65_17395	COG1666	GTP binding
CBW65_17400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBW65_17405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBW65_17410	COG1058	Belongs to the CinA family
CBW65_17410	COG1546	Belongs to the CinA family
CBW65_17425	COG2137	regulation of response to DNA damage stimulus
CBW65_17430	COG1418	mRNA catabolic process
CBW65_17440	COG1692	metallophosphoesterase
CBW65_17445	COG2359	stage V sporulation protein S
CBW65_17455	COG0613	PHP domain protein
CBW65_17460	COG4869	propanediol catabolic process
CBW65_17465	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CBW65_17490	COG0531	amino acid
CBW65_17495	COG0583	DNA-binding transcription factor activity
CBW65_17515	COG0189	ligase activity
CBW65_17535	COG0189	ligase activity
CBW65_17540	COG0384	phenazine biosynthesis protein PhzF
CBW65_17545	COG0688	phosphatidylethanolamine metabolic process
CBW65_17560	COG2112	serine threonine protein kinase
CBW65_17575	COG1061	Type III restriction enzyme res subunit
CBW65_17585	COG5582	Belongs to the UPF0302 family
CBW65_17600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CBW65_17605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CBW65_17605	COG2010	Cytochrome c
CBW65_17620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBW65_17630	COG0586	Pfam SNARE associated Golgi protein
CBW65_17635	COG3949	Membrane
CBW65_17640	COG1968	undecaprenyl-diphosphatase activity
CBW65_17645	COG3314	Sporulation integral membrane protein YlbJ
CBW65_17650	COG1694	Mazg nucleotide pyrophosphohydrolase
CBW65_17655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CBW65_17660	COG1803	Methylglyoxal synthase
CBW65_17665	COG0617	tRNA 3'-terminal CCA addition
CBW65_17695	COG0784	Response regulator, receiver
CBW65_17695	COG3437	response regulator, receiver
CBW65_17715	COG0489	protein tyrosine kinase activity
CBW65_17720	COG4464	protein tyrosine phosphatase activity
CBW65_17740	COG1215	transferase activity, transferring glycosyl groups
CBW65_17745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CBW65_17750	COG1316	TRANSCRIPTIONal
CBW65_17755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_17765	COG3483	tryptophan 2,3-dioxygenase activity
CBW65_17780	COG0640	Transcriptional regulator
CBW65_17785	COG2226	methyltransferase
CBW65_17795	COG1222	aaa ATPase
CBW65_17980	COG0714	Associated with various cellular activities
CBW65_18130	COG1396	sequence-specific DNA binding
CBW65_18270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CBW65_18275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CBW65_18285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CBW65_18295	COG0135	phosphoribosylanthranilate isomerase activity
CBW65_18300	COG0133	tryptophan synthase activity
CBW65_18310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CBW65_18325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CBW65_18335	COG0586	Pfam SNARE associated Golgi protein
CBW65_18350	COG1404	Belongs to the peptidase S8 family
CBW65_18355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBW65_18370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBW65_18375	COG2136	Putative SAM-dependent methyltransferase
CBW65_18375	COG2521	methyltransferase
CBW65_18380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CBW65_18385	COG1923	regulation of RNA biosynthetic process
CBW65_18470	COG2409	Drug exporters of the RND superfamily
CBW65_18470	COG1033	growth of symbiont in host cell
CBW65_18475	COG1309	transcriptional regulator
CBW65_18480	COG0482	sulfurtransferase activity
CBW65_18505	COG5002	protein histidine kinase activity
CBW65_18635	COG0697	spore germination
CBW65_18640	COG0531	amino acid
CBW65_18715	COG4166	transmembrane transport
CBW65_18735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBW65_18740	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CBW65_18745	COG0464	growth
CBW65_18750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBW65_18775	COG0531	amino acid
CBW65_18790	COG0697	spore germination
CBW65_18810	COG3844	kynureninase activity
CBW65_18820	COG1741	Belongs to the pirin family
CBW65_18830	COG0693	protein deglycase activity
CBW65_18895	COG0493	'glutamate synthase
CBW65_18900	COG0167	dihydroorotate dehydrogenase activity
CBW65_18900	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CBW65_18915	COG1953	Uracil, thiamine, allantoin
CBW65_18935	COG5337	Spore coat protein CotH
CBW65_18940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBW65_18950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CBW65_18990	COG2986	histidine ammonia-lyase
CBW65_19000	COG1228	amidohydrolase
CBW65_19005	COG0010	Belongs to the arginase family
CBW65_19025	COG3706	GGDEF domain
CBW65_19035	COG1404	Belongs to the peptidase S8 family
CBW65_19040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_19090	COG2259	Doxx family
CBW65_19110	COG0477	Major facilitator Superfamily
CBW65_19130	COG1846	Transcriptional regulator
CBW65_19130	COG0456	acetyltransferase
CBW65_19135	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_19145	COG2738	Putative neutral zinc metallopeptidase
CBW65_19170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CBW65_19185	COG3858	chitin binding
CBW65_19185	COG1388	LysM domain
CBW65_19195	COG0363	glucosamine-6-phosphate deaminase activity
CBW65_19200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CBW65_19205	COG0395	ABC-type sugar transport system, permease component
CBW65_19210	COG1175	transmembrane transport
CBW65_19220	COG3876	Protein conserved in bacteria
CBW65_19225	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CBW65_19230	COG1472	Belongs to the glycosyl hydrolase 3 family
CBW65_19235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CBW65_19240	COG2971	BadF BadG BcrA BcrD
CBW65_19255	COG2385	sporulation resulting in formation of a cellular spore
CBW65_19255	COG2247	cell wall binding repeat
CBW65_19285	COG0559	Belongs to the binding-protein-dependent transport system permease family
CBW65_19295	COG0411	ABC transporter
CBW65_19305	COG0733	neurotransmitter:sodium symporter activity
CBW65_19310	COG0740	serine-type endopeptidase activity
CBW65_19340	COG0318	PFAM AMP-dependent synthetase and ligase
CBW65_19345	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_19350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CBW65_19355	COG0174	glutamine synthetase
CBW65_19360	COG0789	Transcriptional regulator
CBW65_19365	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CBW65_19375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CBW65_19405	COG0488	(ABC) transporter
CBW65_19415	COG3935	DnaD domain protein
CBW65_19420	COG0017	Asparaginyl-tRNA synthetase
CBW65_19425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CBW65_19430	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_19440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBW65_19455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CBW65_19465	COG0402	S-adenosylhomocysteine deaminase activity
CBW65_19470	COG0235	Class ii aldolase
CBW65_19475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CBW65_19480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CBW65_19490	COG1793	dna ligase
CBW65_19495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CBW65_19500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CBW65_19510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CBW65_19510	COG1199	ATP-dependent helicase activity
CBW65_19530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CBW65_19535	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CBW65_19600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CBW65_19600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_19605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CBW65_19610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CBW65_19615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CBW65_19620	COG0028	Belongs to the TPP enzyme family
CBW65_19620	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CBW65_19645	COG3383	formate dehydrogenase (NAD+) activity
CBW65_19650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CBW65_19660	COG1917	Cupin 2, conserved barrel domain protein
CBW65_19660	COG2207	Transcriptional regulator
CBW65_19670	COG0589	response to stress
CBW65_19710	COG2329	Antibiotic biosynthesis monooxygenase
CBW65_19715	COG2855	membrane
CBW65_19725	COG0564	pseudouridine synthase activity
CBW65_19735	COG0438	transferase activity, transferring glycosyl groups
CBW65_19780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CBW65_19790	COG0105	UTP biosynthetic process
CBW65_19800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CBW65_19810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CBW65_19820	COG2226	methyltransferase
CBW65_19840	COG2155	Conserved Protein
CBW65_19860	COG0492	ferredoxin-NADP+ reductase activity
CBW65_19880	COG3695	enzyme binding
CBW65_19885	COG0726	polysaccharide deacetylase
CBW65_19910	COG0488	(ABC) transporter
CBW65_19920	COG1484	DNA-dependent DNA replication
CBW65_20015	COG5549	protein import
CBW65_20015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_20050	COG0179	Fumarylacetoacetate (FAA) hydrolase
CBW65_20065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CBW65_20075	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBW65_20080	COG0095	Lipoate-protein ligase
CBW65_20085	COG0509	glycine decarboxylation via glycine cleavage system
CBW65_20090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CBW65_20095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBW65_20140	COG1304	FMN binding
CBW65_20155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CBW65_20175	COG2959	enzyme of heme biosynthesis
CBW65_20180	COG3409	Peptidoglycan-binding domain 1 protein
CBW65_20180	COG3773	Cell wall hydrolase
CBW65_20185	COG2339	peptidase activity
CBW65_20195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CBW65_20205	COG0626	cystathionine gamma-synthase activity
CBW65_20210	COG0626	cystathionine gamma-synthase activity
CBW65_20215	COG2814	Major facilitator Superfamily
CBW65_20240	COG1809	phosphosulfolactate synthase activity
CBW65_20245	COG2707	UPF0756 membrane protein
CBW65_20255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_20260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_20265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBW65_20270	COG1609	Transcriptional regulator
CBW65_20280	COG4637	Psort location Cytoplasmic, score
CBW65_20285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CBW65_20320	COG3858	chitin binding
CBW65_20325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CBW65_20330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CBW65_20335	COG0438	transferase activity, transferring glycosyl groups
CBW65_20340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBW65_20350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CBW65_20385	COG0210	DNA helicase
CBW65_20400	COG3091	SprT-like family
CBW65_20410	COG0840	transmembrane signaling receptor activity
CBW65_20415	COG0705	Rhomboid family
CBW65_20415	COG0457	Tetratricopeptide repeat
CBW65_20430	COG0302	gtp cyclohydrolase
CBW65_20435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBW65_20445	COG0726	polysaccharide deacetylase
CBW65_20450	COG1278	Cold shock
CBW65_20460	COG0300	oxidoreductase activity
CBW65_20465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CBW65_20470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBW65_20475	COG1388	LysM domain
CBW65_20475	COG0791	NLP P60 protein
CBW65_20490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBW65_20505	COG2814	Major facilitator Superfamily
CBW65_20515	COG0312	modulator of DNA gyrase
CBW65_20520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_20550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_20560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBW65_20590	COG0431	NADPH-dependent FMN reductase
CBW65_20595	COG0681	Belongs to the peptidase S26 family
CBW65_20635	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CBW65_20655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBW65_20660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CBW65_20665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CBW65_20690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_20705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CBW65_20710	COG2022	thiamine diphosphate biosynthetic process
CBW65_20720	COG0352	thiamine-phosphate diphosphorylase activity
CBW65_20730	COG1832	CoA-binding protein
CBW65_20740	COG5002	protein histidine kinase activity
CBW65_20745	COG0745	RESPONSE REGULATOR receiver
CBW65_20750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CBW65_20755	COG1333	cytochrome c biogenesis protein
CBW65_20760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_20770	COG1187	pseudouridine synthase activity
CBW65_20780	COG0700	Nucleoside recognition
CBW65_20785	COG2715	membrane protein required for spore maturation
CBW65_20790	COG1686	Belongs to the peptidase S11 family
CBW65_20795	COG3874	Sporulation protein YtfJ
CBW65_20805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CBW65_20810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CBW65_20815	COG1994	Peptidase M50
CBW65_20820	COG0477	Major facilitator Superfamily
CBW65_20825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CBW65_20840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBW65_20840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBW65_20845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBW65_20850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBW65_20855	COG1686	Belongs to the peptidase S11 family
CBW65_20865	COG3773	Cell wall hydrolase
CBW65_20865	COG3409	Peptidoglycan-binding domain 1 protein
CBW65_20870	COG0019	diaminopimelate decarboxylase activity
CBW65_20875	COG0697	spore germination
CBW65_20890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBW65_20900	COG1191	sigma factor activity
CBW65_20910	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_20915	COG0446	pyridine nucleotide-disulphide oxidoreductase
CBW65_20920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_20985	COG2217	Heavy metal translocating P-type atpase
CBW65_20990	COG0840	transmembrane signaling receptor activity
CBW65_21010	COG0514	ATP-dependent DNA helicase (RecQ)
CBW65_21020	COG4187	Peptidase family M20/M25/M40
CBW65_21025	COG1686	Belongs to the peptidase S11 family
CBW65_21040	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CBW65_21045	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_21050	COG4974	Belongs to the 'phage' integrase family
CBW65_21060	COG0686	Belongs to the AlaDH PNT family
CBW65_21065	COG0735	belongs to the Fur family
CBW65_21080	COG1300	Membrane
CBW65_21085	COG1379	DNA repair
CBW65_21090	COG0494	nUDIX hydrolase
CBW65_21105	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBW65_21125	COG0697	spore germination
CBW65_21130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBW65_21145	COG0840	transmembrane signaling receptor activity
CBW65_21150	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBW65_21160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CBW65_21165	COG0346	lactoylglutathione lyase activity
CBW65_21170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_21170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_21175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_21175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_21180	COG0180	Tryptophanyl-tRNA synthetase
CBW65_21195	COG0321	lipoyl(octanoyl) transferase activity
CBW65_21200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CBW65_21205	COG0508	dehydrogenase complex catalyzes the overall conversion of
CBW65_21210	COG0022	dehydrogenase e1 component
CBW65_21215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CBW65_21220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CBW65_21225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CBW65_21230	COG3829	transcription factor binding
CBW65_21230	COG3290	protein histidine kinase activity
CBW65_21245	COG3858	chitin binding
CBW65_21270	COG0521	Mo-molybdopterin cofactor biosynthetic process
CBW65_21275	COG0315	cyclic pyranopterin monophosphate synthase activity
CBW65_21280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CBW65_21285	COG0314	molybdopterin synthase activity
CBW65_21290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CBW65_21315	COG0697	spore germination
CBW65_21320	COG3361	conserved protein (COG2071)
CBW65_21330	COG0726	polysaccharide deacetylase
CBW65_21335	COG2223	nitrite transmembrane transporter activity
CBW65_21350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CBW65_21355	COG0006	proline dipeptidase activity
CBW65_21370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CBW65_21375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CBW65_21380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CBW65_21385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CBW65_21415	COG4492	Belongs to the UPF0735 family
CBW65_21420	COG0367	asparagine synthase
CBW65_21425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CBW65_21470	COG4537	Required for transformation and DNA binding
CBW65_21485	COG1408	metallophosphoesterase
CBW65_21495	COG1619	proteins homologs of microcin C7 resistance protein MccF
CBW65_21505	COG0730	response to heat
CBW65_21515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBW65_21525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CBW65_21535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CBW65_21540	COG1530	ribonuclease E activity
CBW65_21545	COG0750	zinc metalloprotease
CBW65_21555	COG2894	cell division
CBW65_21560	COG0850	regulation of cytokinetic process
CBW65_21575	COG1792	Involved in formation and maintenance of cell shape
CBW65_21580	COG1077	Cell shape determining protein MreB Mrl
CBW65_21590	COG0424	maF-like protein
CBW65_21595	COG1027	Aspartate ammonia-lyase
CBW65_21610	COG3583	domain protein
CBW65_21610	COG3584	3D domain protein
CBW65_21615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CBW65_21630	COG0525	valine-tRNA ligase activity
CBW65_21640	COG1136	(ABC) transporter
CBW65_21640	COG0577	efflux transmembrane transporter activity
CBW65_21650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBW65_21655	COG0791	NLP P60 protein
CBW65_21655	COG1388	LysM domain
CBW65_21695	COG4912	Dna alkylation repair
CBW65_21715	COG1388	LysM domain
CBW65_21725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CBW65_21755	COG0564	pseudouridine synthase activity
CBW65_21765	COG2233	PERMEase
CBW65_21770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBW65_21775	COG0113	porphobilinogen synthase activity
CBW65_21785	COG0181	hydroxymethylbilane synthase activity
CBW65_21790	COG1648	precorrin-2 dehydrogenase activity
CBW65_21790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CBW65_21795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CBW65_21800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CBW65_21805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CBW65_21815	COG1116	anion transmembrane transporter activity
CBW65_21820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CBW65_21825	COG0697	spore germination
CBW65_21835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CBW65_21845	COG1067	ATP-dependent peptidase activity
CBW65_21845	COG0470	DNA polymerase III
CBW65_21850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CBW65_21855	COG0544	peptidyl-prolyl cis-trans isomerase activity
CBW65_21885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CBW65_21890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CBW65_21900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CBW65_21905	COG1846	Transcriptional regulator
CBW65_21910	COG2814	Major facilitator Superfamily
CBW65_21915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CBW65_21945	COG2197	response regulator
CBW65_21950	COG1406	Chemotaxis phosphatase CheX
CBW65_21955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CBW65_21960	COG1053	succinate dehydrogenase
CBW65_21965	COG2009	succinate dehydrogenase
CBW65_21970	COG0460	homoserine dehydrogenase
CBW65_21975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CBW65_21990	COG0322	excinuclease ABC activity
CBW65_21995	COG3118	belongs to the thioredoxin family
CBW65_22000	COG0071	Belongs to the small heat shock protein (HSP20) family
CBW65_22005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBW65_22005	COG5322	oxidoreductase activity
CBW65_22020	COG0697	spore germination
CBW65_22030	COG1842	Phage shock protein A
CBW65_22035	COG4166	transmembrane transport
CBW65_22040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CBW65_22045	COG0454	-acetyltransferase
CBW65_22050	COG0517	IMP dehydrogenase activity
CBW65_22055	COG0123	including yeast histone deacetylase and acetoin utilization protein
CBW65_22065	COG1376	ErfK ybiS ycfS ynhG family protein
CBW65_22070	COG3278	Belongs to the heme-copper respiratory oxidase family
CBW65_22095	COG4585	Histidine kinase
CBW65_22100	COG2197	response regulator
CBW65_22115	COG4549	nuclear export factor GLE1
CBW65_22120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CBW65_22120	COG1605	Chorismate mutase
CBW65_22125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBW65_22130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CBW65_22140	COG0697	spore germination
CBW65_22165	COG0741	lytic transglycosylase activity
CBW65_22170	COG0387	Pfam Sodium calcium exchanger
CBW65_22180	COG2827	Endonuclease containing a URI domain
CBW65_22185	COG1132	(ABC) transporter
CBW65_22190	COG1132	(ABC) transporter
CBW65_22235	COG0598	Magnesium transport protein CorA
CBW65_22245	COG0814	amino acid
CBW65_22250	COG0697	spore germination
CBW65_22255	COG1253	flavin adenine dinucleotide binding
CBW65_22270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBW65_22280	COG0318	PFAM AMP-dependent synthetase and ligase
CBW65_22285	COG1024	Enoyl-CoA hydratase
CBW65_22295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CBW65_22300	COG0598	Magnesium transport protein CorA
CBW65_22305	COG0598	Magnesium transport protein CorA
CBW65_22325	COG1959	2 iron, 2 sulfur cluster binding
CBW65_22335	COG1801	Protein of unknown function DUF72
CBW65_22400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBW65_22405	COG2770	Histidine kinase
CBW65_22405	COG3437	response regulator, receiver
CBW65_22410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CBW65_22415	COG1132	(ABC) transporter
CBW65_22420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBW65_22430	COG0626	cystathionine gamma-synthase activity
CBW65_22455	COG1061	Type III restriction enzyme res subunit
CBW65_22470	COG0601	transmembrane transport
CBW65_22480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CBW65_22505	COG0523	cobalamin synthesis protein
CBW65_22520	COG3436	PFAM IS66 Orf2 family protein
CBW65_22525	COG4372	Transposase
CBW65_22565	COG1484	DNA-dependent DNA replication
CBW65_22605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBW65_22625	COG2323	membrane
CBW65_22635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_22655	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_22685	COG0077	Prephenate dehydratase
CBW65_22690	COG0077	Prephenate dehydratase
CBW65_22690	COG1605	Chorismate mutase
CBW65_22695	COG0183	Belongs to the thiolase family
CBW65_22720	COG0714	Associated with various cellular activities
CBW65_22725	COG2084	Dehydrogenase
CBW65_22730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CBW65_22735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBW65_22740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBW65_22740	COG1321	iron dependent repressor
CBW65_22745	COG1121	(ABC) transporter
CBW65_22750	COG0803	Belongs to the bacterial solute-binding protein 9 family
CBW65_22755	COG1141	Ferredoxin
CBW65_22770	COG1595	DNA-templated transcription, initiation
CBW65_22800	COG1596	polysaccharide export
CBW65_22800	COG1555	photosystem II stabilization
CBW65_22805	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CBW65_22810	COG1321	iron dependent repressor
CBW65_22815	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBW65_22825	COG0495	leucyl-tRNA aminoacylation
CBW65_22830	COG3858	chitin binding
CBW65_22830	COG1388	LysM domain
CBW65_22835	COG2226	methyltransferase
CBW65_22840	COG0799	negative regulation of ribosome biogenesis
CBW65_22845	COG1713	HD superfamily hydrolase involved in NAD metabolism
CBW65_22855	COG1534	Rna-binding protein
CBW65_22860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CBW65_22870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CBW65_22875	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CBW65_22885	COG1388	LysM domain
CBW65_22885	COG0791	NLP P60 protein
CBW65_22900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CBW65_22940	COG2814	Major facilitator Superfamily
CBW65_22955	COG1191	sigma factor activity
CBW65_22960	COG0768	penicillin binding
CBW65_22965	COG0572	uridine kinase
CBW65_22975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CBW65_22985	COG3906	Belongs to the UPF0473 family
CBW65_22990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CBW65_22995	COG4472	Bacterial protein of unknown function (DUF965)
CBW65_23000	COG0628	permease
CBW65_23020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_23025	COG0450	alkyl hydroperoxide reductase
CBW65_23060	COG1104	cysteine desulfurase activity
CBW65_23065	COG1959	2 iron, 2 sulfur cluster binding
CBW65_23070	COG2364	Membrane
CBW65_23090	COG0024	Methionine aminopeptidase
CBW65_23100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CBW65_23105	COG0124	histidyl-tRNA synthetase
CBW65_23115	COG2244	polysaccharide biosynthetic process
CBW65_23120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_23125	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_23130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CBW65_23155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBW65_23165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CBW65_23170	COG1418	mRNA catabolic process
CBW65_23180	COG0646	methionine synthase
CBW65_23180	COG1410	methionine synthase
CBW65_23215	COG1063	alcohol dehydrogenase
CBW65_23235	COG0531	amino acid
CBW65_23240	COG5002	protein histidine kinase activity
CBW65_23260	COG0427	acetyl-CoA hydrolase
CBW65_23265	COG2217	Heavy metal translocating P-type atpase
CBW65_23325	COG1794	racemase activity, acting on amino acids and derivatives
CBW65_23415	COG2311	Membrane
CBW65_23435	COG1164	Oligoendopeptidase f
CBW65_23445	COG2205	protein histidine kinase activity
CBW65_23495	COG3290	protein histidine kinase activity
CBW65_23495	COG3829	transcription factor binding
CBW65_23500	COG2610	gluconate transmembrane transporter activity
CBW65_23505	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_23510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CBW65_23515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBW65_23520	COG1794	racemase activity, acting on amino acids and derivatives
CBW65_23540	COG2807	transmembrane transport
CBW65_23545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CBW65_23550	COG0778	Nitroreductase
CBW65_23555	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CBW65_23565	COG0326	Molecular chaperone. Has ATPase activity
CBW65_23595	COG3878	Protein conserved in bacteria
CBW65_23620	COG1396	sequence-specific DNA binding
CBW65_23650	COG4372	Transposase
CBW65_23655	COG3436	PFAM IS66 Orf2 family protein
CBW65_23725	COG0697	spore germination
CBW65_23730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBW65_23735	COG2814	Major facilitator Superfamily
CBW65_23755	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CBW65_23775	COG1490	D-aminoacyl-tRNA deacylase activity
CBW65_23780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CBW65_23785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBW65_23790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBW65_23790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBW65_23795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBW65_23800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBW65_23815	COG2244	polysaccharide biosynthetic process
CBW65_23820	COG2323	membrane
CBW65_23825	COG3706	GGDEF domain
CBW65_23835	COG1862	Preprotein translocase
CBW65_23845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CBW65_23850	COG2385	sporulation resulting in formation of a cellular spore
CBW65_23865	COG1191	sigma factor activity
CBW65_23870	COG2255	four-way junction helicase activity
CBW65_23875	COG0632	four-way junction helicase activity
CBW65_23895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CBW65_23900	COG2211	Major facilitator Superfamily
CBW65_23905	COG2814	Major facilitator Superfamily
CBW65_23915	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_23935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system