locus-tag	class	description
HLK68_00020	COG1686	Belongs to the peptidase S11 family
HLK68_00025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HLK68_00045	COG0204	Acyl-transferase
HLK68_00050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK68_00060	COG2521	methyltransferase
HLK68_00060	COG2136	Putative SAM-dependent methyltransferase
HLK68_00065	COG2211	Major facilitator Superfamily
HLK68_00070	COG0629	single-stranded DNA binding
HLK68_00080	COG0612	Peptidase, M16
HLK68_00085	COG2340	Cysteine-rich secretory protein family
HLK68_00090	COG0813	purine-nucleoside phosphorylase activity
HLK68_00095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLK68_00100	COG0628	permease
HLK68_00115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLK68_00130	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_00145	COG1368	sulfuric ester hydrolase activity
HLK68_00150	COG4485	Bacterial membrane protein, YfhO
HLK68_00170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_00190	COG1216	Glycosyl transferase, family 2
HLK68_00200	COG0297	glycogen (starch) synthase activity
HLK68_00205	COG1442	glycosyl transferase family 8
HLK68_00205	COG1216	Glycosyl transferase, family 2
HLK68_00210	COG1216	Glycosyl transferase, family 2
HLK68_00210	COG1442	glycosyl transferase family 8
HLK68_00215	COG1216	Glycosyl transferase, family 2
HLK68_00215	COG1442	glycosyl transferase family 8
HLK68_00225	COG1316	TRANSCRIPTIONal
HLK68_00245	COG0124	histidyl-tRNA synthetase
HLK68_00250	COG1490	D-aminoacyl-tRNA deacylase activity
HLK68_00255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLK68_00260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK68_00265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HLK68_00265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLK68_00270	COG2244	polysaccharide biosynthetic process
HLK68_00275	COG2323	membrane
HLK68_00285	COG1862	Preprotein translocase
HLK68_00290	COG0343	queuine tRNA-ribosyltransferase activity
HLK68_00295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLK68_00310	COG0632	four-way junction helicase activity
HLK68_00315	COG2116	formate transmembrane transporter activity
HLK68_00345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLK68_00370	COG4989	oxidoreductase activity
HLK68_00415	COG0733	neurotransmitter:sodium symporter activity
HLK68_00430	COG3621	Patatin-like phospholipase
HLK68_00465	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HLK68_00720	COG0671	phosphoesterase, PA-phosphatase related
HLK68_00740	COG0116	Belongs to the methyltransferase superfamily
HLK68_00765	COG4677	pectinesterase activity
HLK68_00775	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_00795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK68_00800	COG2188	Transcriptional regulator
HLK68_00805	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HLK68_00810	COG4608	Belongs to the ABC transporter superfamily
HLK68_00815	COG0444	Belongs to the ABC transporter superfamily
HLK68_00825	COG0601	transmembrane transport
HLK68_00830	COG0747	negative chemotaxis
HLK68_00835	COG0363	glucosamine-6-phosphate deaminase activity
HLK68_00840	COG1940	carbohydrate kinase activity
HLK68_00855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK68_00865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLK68_00870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLK68_00880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLK68_00890	COG1994	Peptidase M50
HLK68_00925	COG2003	Belongs to the UPF0758 family
HLK68_00935	COG0285	dihydrofolate synthase activity
HLK68_00960	COG1363	Peptidase, m42
HLK68_00970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLK68_00975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLK68_00985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK68_00990	COG1484	DNA-dependent DNA replication
HLK68_00995	COG3611	Membrane attachment protein
HLK68_01005	COG0237	dephospho-CoA kinase activity
HLK68_01025	COG1164	Oligoendopeptidase f
HLK68_01030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HLK68_01035	COG4509	Sortase family
HLK68_01045	COG0577	efflux transmembrane transporter activity
HLK68_01045	COG1136	(ABC) transporter
HLK68_01050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK68_01050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK68_01055	COG1408	metallophosphoesterase
HLK68_01065	COG2084	Dehydrogenase
HLK68_01085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLK68_01095	COG2190	(PTS) system
HLK68_01095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_01095	COG1263	PTS System
HLK68_01105	COG0142	geranyltranstransferase activity
HLK68_01110	COG1252	NADH dehydrogenase
HLK68_01130	COG1051	belongs to the nudix hydrolase family
HLK68_01135	COG0469	pyruvate kinase activity
HLK68_01140	COG0205	6-phosphofructokinase activity
HLK68_01145	COG0587	DNA-directed DNA polymerase activity
HLK68_01150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLK68_01155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLK68_01160	COG0827	DNA restriction-modification system
HLK68_01165	COG3874	Sporulation protein YtfJ
HLK68_01175	COG0367	asparagine synthase
HLK68_01180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLK68_01185	COG2860	membrane
HLK68_01190	COG0488	(ABC) transporter
HLK68_01195	COG1362	aminopeptidase activity
HLK68_01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK68_01270	COG1045	serine acetyltransferase
HLK68_01285	COG1098	S1 RNA binding domain
HLK68_01290	COG0492	ferredoxin-NADP+ reductase activity
HLK68_01295	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLK68_01300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLK68_01310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLK68_01315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLK68_01320	COG0647	UMP catabolic process
HLK68_01325	COG4470	Protein conserved in bacteria
HLK68_01340	COG0534	Mate efflux family protein
HLK68_01345	COG1609	Transcriptional regulator
HLK68_01355	COG1126	abc transporter atp-binding protein
HLK68_01360	COG0765	amino acid transport
HLK68_01370	COG3842	ATPase activity
HLK68_01375	COG2508	Transcriptional regulator
HLK68_01385	COG2801	Transposase and inactivated derivatives
HLK68_01395	COG0564	pseudouridine synthase activity
HLK68_01400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLK68_01405	COG2357	RelA SpoT domain protein
HLK68_01410	COG4116	CYTH
HLK68_01425	COG1393	Belongs to the ArsC family
HLK68_01430	COG4608	Belongs to the ABC transporter superfamily
HLK68_01435	COG0444	Belongs to the ABC transporter superfamily
HLK68_01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK68_01445	COG0601	transmembrane transport
HLK68_01450	COG4166	transmembrane transport
HLK68_01460	COG1132	(ABC) transporter
HLK68_01465	COG1132	(ABC) transporter
HLK68_01480	COG0561	phosphatase activity
HLK68_01485	COG0495	leucyl-tRNA aminoacylation
HLK68_01490	COG1242	4 iron, 4 sulfur cluster binding
HLK68_01495	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HLK68_01520	COG0149	triose-phosphate isomerase activity
HLK68_01525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK68_01530	COG4191	Histidine kinase
HLK68_01530	COG0784	Response regulator, receiver
HLK68_01535	COG0697	spore germination
HLK68_01560	COG0789	Transcriptional regulator
HLK68_01560	COG4978	Transcriptional regulator
HLK68_01570	COG2205	protein histidine kinase activity
HLK68_01575	COG0745	RESPONSE REGULATOR receiver
HLK68_01580	COG2267	carboxylic ester hydrolase activity
HLK68_01595	COG2205	protein histidine kinase activity
HLK68_01600	COG0745	RESPONSE REGULATOR receiver
HLK68_01615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK68_01620	COG1757	Na H antiporter
HLK68_01645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK68_01655	COG0697	spore germination
HLK68_01660	COG0038	chloride channel
HLK68_01730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK68_01800	COG1215	transferase activity, transferring glycosyl groups
HLK68_01810	COG1216	Glycosyl transferase, family 2
HLK68_01810	COG1442	glycosyl transferase family 8
HLK68_01815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLK68_01825	COG1216	Glycosyl transferase, family 2
HLK68_01825	COG1442	glycosyl transferase family 8
HLK68_01835	COG0438	transferase activity, transferring glycosyl groups
HLK68_01845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLK68_01845	COG0463	Glycosyl transferase, family 2
HLK68_01850	COG0438	transferase activity, transferring glycosyl groups
HLK68_01865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK68_01870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HLK68_01880	COG0489	protein tyrosine kinase activity
HLK68_01895	COG1408	metallophosphoesterase
HLK68_01900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK68_01905	COG1316	TRANSCRIPTIONal
HLK68_01940	COG0489	protein tyrosine kinase activity
HLK68_01950	COG1132	(ABC) transporter
HLK68_02005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK68_02010	COG0489	protein tyrosine kinase activity
HLK68_02035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK68_02065	COG1902	pentaerythritol trinitrate reductase activity
HLK68_02065	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK68_02080	COG3279	Response regulator of the LytR AlgR family
HLK68_02085	COG3706	GGDEF domain
HLK68_02105	COG1881	PFAM PEBP family protein
HLK68_02115	COG0351	phosphomethylpyrimidine kinase
HLK68_02125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HLK68_02135	COG0756	dUTP diphosphatase activity
HLK68_02140	COG0602	queuosine metabolic process
HLK68_02145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_02145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_02145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_02150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_02150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_02150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_02175	COG1328	CTP reductase activity
HLK68_02185	COG1328	CTP reductase activity
HLK68_02185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLK68_02195	COG1328	CTP reductase activity
HLK68_02195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLK68_02225	COG1121	(ABC) transporter
HLK68_02230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK68_02235	COG1121	(ABC) transporter
HLK68_02240	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLK68_02240	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK68_02255	COG1737	Transcriptional regulator
HLK68_02260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_02275	COG1454	alcohol dehydrogenase
HLK68_02280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK68_02285	COG2188	Transcriptional regulator
HLK68_02290	COG0366	Alpha amylase catalytic
HLK68_02295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_02295	COG1263	PTS System
HLK68_02315	COG2207	Transcriptional regulator
HLK68_02315	COG0662	Cupin 2, conserved barrel domain protein
HLK68_02320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLK68_02340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLK68_02350	COG1131	(ABC) transporter
HLK68_02375	COG0577	efflux transmembrane transporter activity
HLK68_02380	COG1136	(ABC) transporter
HLK68_02390	COG0561	phosphatase activity
HLK68_02395	COG1349	DNA-binding transcription factor activity
HLK68_02405	COG2972	Histidine kinase
HLK68_02410	COG2207	Transcriptional regulator
HLK68_02410	COG4753	response regulator
HLK68_02430	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_02435	COG1874	Beta-galactosidase
HLK68_02440	COG0546	phosphoglycolate phosphatase activity
HLK68_02450	COG1253	flavin adenine dinucleotide binding
HLK68_02465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLK68_02470	COG0248	Ppx GppA phosphatase
HLK68_02490	COG0656	L-ascorbic acid biosynthetic process
HLK68_02495	COG0656	L-ascorbic acid biosynthetic process
HLK68_02510	COG0402	S-adenosylhomocysteine deaminase activity
HLK68_02515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLK68_02520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLK68_02525	COG3842	ATPase activity
HLK68_02530	COG0395	ABC-type sugar transport system, permease component
HLK68_02535	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK68_02540	COG0584	glycerophosphoryl diester phosphodiesterase
HLK68_02545	COG1959	2 iron, 2 sulfur cluster binding
HLK68_02560	COG0038	chloride channel
HLK68_02575	COG1940	carbohydrate kinase activity
HLK68_02580	COG1940	carbohydrate kinase activity
HLK68_02600	COG0383	alpha-mannosidase activity
HLK68_02610	COG0395	ABC-type sugar transport system, permease component
HLK68_02615	COG4209	transmembrane transport
HLK68_02625	COG2972	Histidine kinase
HLK68_02635	COG1482	cell wall glycoprotein biosynthetic process
HLK68_02640	COG2723	6-phospho-beta-galactosidase activity
HLK68_02645	COG0577	efflux transmembrane transporter activity
HLK68_02650	COG1136	(ABC) transporter
HLK68_02655	COG0642	Histidine kinase
HLK68_02660	COG0745	RESPONSE REGULATOR receiver
HLK68_02680	COG1307	EDD domain protein, DegV family
HLK68_02685	COG0726	polysaccharide deacetylase
HLK68_02700	COG0584	glycerophosphoryl diester phosphodiesterase
HLK68_02705	COG2508	Transcriptional regulator
HLK68_02735	COG1126	abc transporter atp-binding protein
HLK68_02740	COG4215	(ABC) transporter
HLK68_02760	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_02765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK68_02775	COG1760	l-serine dehydratase
HLK68_02780	COG0556	nucleotide-excision repair
HLK68_02785	COG3409	Peptidoglycan-binding domain 1 protein
HLK68_02785	COG0793	Belongs to the peptidase S41A family
HLK68_02795	COG2177	Part of the ABC transporter FtsEX involved in
HLK68_02800	COG2884	Cell division ATP-binding protein ftsE
HLK68_02805	COG1854	S-ribosylhomocysteine lyase activity
HLK68_02810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HLK68_02820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLK68_02830	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HLK68_02835	COG1105	Belongs to the carbohydrate kinase PfkB family
HLK68_02865	COG1307	EDD domain protein, DegV family
HLK68_02870	COG1739	Uncharacterized protein family UPF0029
HLK68_02875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLK68_02880	COG1077	Cell shape determining protein MreB Mrl
HLK68_02890	COG2385	sporulation resulting in formation of a cellular spore
HLK68_02900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HLK68_02905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLK68_02910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLK68_02915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLK68_02925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLK68_02930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLK68_02935	COG0356	it plays a direct role in the translocation of protons across the membrane
HLK68_02950	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLK68_02955	COG0698	ribose 5-phosphate isomerase
HLK68_02970	COG0009	L-threonylcarbamoyladenylate synthase
HLK68_02975	COG2890	protein-(glutamine-N5) methyltransferase activity
HLK68_02980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLK68_02985	COG0305	Participates in initiation and elongation during chromosome replication
HLK68_02990	COG0359	binds to the 23S rRNA
HLK68_02995	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HLK68_03010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLK68_03015	COG0629	single-stranded DNA binding
HLK68_03025	COG3639	organic phosphonate transmembrane transporter activity
HLK68_03030	COG3639	organic phosphonate transmembrane transporter activity
HLK68_03035	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLK68_03045	COG0012	GTP binding
HLK68_03055	COG1215	transferase activity, transferring glycosyl groups
HLK68_03080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLK68_03130	COG1459	type II secretion system
HLK68_03145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK68_03160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLK68_03165	COG0084	hydrolase, TatD family'
HLK68_03170	COG4608	Belongs to the ABC transporter superfamily
HLK68_03175	COG0444	Belongs to the ABC transporter superfamily
HLK68_03180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK68_03185	COG0601	transmembrane transport
HLK68_03190	COG4166	transmembrane transport
HLK68_03210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLK68_03215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLK68_03225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_03230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLK68_03235	COG1774	PSP1 C-terminal conserved region
HLK68_03240	COG0470	DNA polymerase III
HLK68_03245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLK68_03260	COG0101	tRNA pseudouridine synthase activity
HLK68_03270	COG1122	ATPase activity
HLK68_03285	COG1132	(ABC) transporter
HLK68_03420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLK68_03425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLK68_03435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLK68_03440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HLK68_03445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLK68_03450	COG0534	Mate efflux family protein
HLK68_03460	COG0789	Transcriptional regulator
HLK68_03470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLK68_03475	COG0581	inorganic phosphate transmembrane transporter activity
HLK68_03480	COG0573	inorganic phosphate transmembrane transporter activity
HLK68_03485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLK68_03490	COG5002	protein histidine kinase activity
HLK68_03495	COG0745	RESPONSE REGULATOR receiver
HLK68_03505	COG0590	tRNA wobble adenosine to inosine editing
HLK68_03515	COG1428	Deoxynucleoside kinase
HLK68_03520	COG1428	Deoxynucleoside kinase
HLK68_03535	COG1918	ferrous iron import across plasma membrane
HLK68_03535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLK68_03550	COG1435	thymidine kinase activity
HLK68_03555	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK68_03560	COG1473	amidohydrolase
HLK68_03595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLK68_03600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLK68_03605	COG0789	Transcriptional regulator
HLK68_03610	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HLK68_03625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLK68_03640	COG0281	malic enzyme
HLK68_03650	COG0622	Phosphoesterase
HLK68_03670	COG0174	glutamine synthetase
HLK68_03680	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_03690	COG0284	orotidine-5'-phosphate decarboxylase activity
HLK68_03695	COG1733	regulation of RNA biosynthetic process
HLK68_03725	COG0543	2 iron, 2 sulfur cluster binding
HLK68_03730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLK68_03740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLK68_03745	COG0540	Belongs to the ATCase OTCase family
HLK68_03750	COG2233	PERMEase
HLK68_03755	COG1418	mRNA catabolic process
HLK68_03770	COG0706	membrane insertase activity
HLK68_03775	COG0706	membrane insertase activity
HLK68_03780	COG2116	formate transmembrane transporter activity
HLK68_03790	COG0426	domain, Protein
HLK68_03795	COG1454	alcohol dehydrogenase
HLK68_03795	COG1012	belongs to the aldehyde dehydrogenase family
HLK68_03800	COG0768	penicillin binding
HLK68_03810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLK68_03825	COG2252	PERMEase
HLK68_03840	COG1363	Peptidase, m42
HLK68_03845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLK68_03880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLK68_03890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLK68_03895	COG1592	Rubrerythrin
HLK68_03905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK68_03940	COG4464	protein tyrosine phosphatase activity
HLK68_03965	COG4607	ABC-type enterochelin transport system periplasmic component
HLK68_03970	COG4604	ABC transporter, ATP-binding protein
HLK68_03975	COG4605	iron ion homeostasis
HLK68_03980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_03985	COG4977	sequence-specific DNA binding
HLK68_03985	COG1917	Cupin 2, conserved barrel domain protein
HLK68_04005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLK68_04010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLK68_04030	COG0534	Mate efflux family protein
HLK68_04035	COG1725	Transcriptional regulator
HLK68_04040	COG1131	(ABC) transporter
HLK68_04050	COG1098	S1 RNA binding domain
HLK68_04080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLK68_04085	COG3956	TIGRFAM MazG family protein
HLK68_04090	COG2244	polysaccharide biosynthetic process
HLK68_04095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK68_04115	COG1132	(ABC) transporter
HLK68_04125	COG1846	Transcriptional regulator
HLK68_04135	COG2199	diguanylate cyclase activity
HLK68_04135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLK68_04155	COG2205	protein histidine kinase activity
HLK68_04160	COG1876	peptidase activity
HLK68_04185	COG2801	Transposase and inactivated derivatives
HLK68_04240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLK68_04245	COG0151	Belongs to the GarS family
HLK68_04250	COG0138	bifunctional purine biosynthesis protein purh
HLK68_04255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLK68_04260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLK68_04265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLK68_04270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLK68_04280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLK68_04285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLK68_04295	COG0517	IMP dehydrogenase activity
HLK68_04295	COG0516	GMP reductase activity
HLK68_04300	COG2002	toxin-antitoxin pair type II binding
HLK68_04305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLK68_04310	COG0193	aminoacyl-tRNA hydrolase activity
HLK68_04315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLK68_04320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLK68_04325	COG2088	sporulation resulting in formation of a cellular spore
HLK68_04330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLK68_04335	COG4466	Protein conserved in bacteria
HLK68_04345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLK68_04350	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLK68_04355	COG1078	dGTPase activity
HLK68_04365	COG4844	belongs to the
HLK68_04370	COG0280	phosphate acetyltransferase
HLK68_04375	COG3773	Cell wall hydrolase
HLK68_04385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLK68_04400	COG0537	adenosine 5'-monophosphoramidase activity
HLK68_04410	COG0142	geranyltranstransferase activity
HLK68_04415	COG0561	phosphatase activity
HLK68_04420	COG1592	Rubrerythrin
HLK68_04425	COG1592	Rubrerythrin
HLK68_04430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLK68_04445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK68_04450	COG2011	ABC-type metal ion transport system permease component
HLK68_04455	COG1464	Belongs to the NlpA lipoprotein family
HLK68_04460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLK68_04465	COG1115	amino acid carrier protein
HLK68_04480	COG0534	Mate efflux family protein
HLK68_04495	COG3546	catalase activity
HLK68_04500	COG0659	secondary active sulfate transmembrane transporter activity
HLK68_04505	COG0513	Belongs to the DEAD box helicase family
HLK68_04510	COG0488	(ABC) transporter
HLK68_04545	COG0393	Putative heavy-metal-binding
HLK68_04560	COG1733	regulation of RNA biosynthetic process
HLK68_04585	COG1595	DNA-templated transcription, initiation
HLK68_04590	COG0393	Putative heavy-metal-binding
HLK68_04595	COG0217	transcriptional regulatory protein
HLK68_04640	COG1397	ADP-ribosylglycohydrolase
HLK68_04645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_04655	COG1482	cell wall glycoprotein biosynthetic process
HLK68_04660	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK68_04665	COG1940	carbohydrate kinase activity
HLK68_04670	COG2723	6-phospho-beta-galactosidase activity
HLK68_04675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK68_04680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK68_04685	COG1940	carbohydrate kinase activity
HLK68_04690	COG2188	Transcriptional regulator
HLK68_04695	COG1876	peptidase activity
HLK68_04700	COG1595	DNA-templated transcription, initiation
HLK68_04725	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK68_04740	COG0745	RESPONSE REGULATOR receiver
HLK68_04745	COG1741	Belongs to the pirin family
HLK68_04750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HLK68_04765	COG0584	glycerophosphoryl diester phosphodiesterase
HLK68_04780	COG0395	ABC-type sugar transport system, permease component
HLK68_04785	COG1175	transmembrane transport
HLK68_04790	COG0737	Belongs to the 5'-nucleotidase family
HLK68_04800	COG1408	metallophosphoesterase
HLK68_04810	COG4978	Transcriptional regulator
HLK68_04810	COG0789	Transcriptional regulator
HLK68_04855	COG0588	phosphoglycerate mutase activity
HLK68_04860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLK68_04875	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HLK68_04875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLK68_04880	COG0387	Pfam Sodium calcium exchanger
HLK68_04885	COG3706	GGDEF domain
HLK68_04890	COG2824	Alkylphosphonate utilization operon protein PhnA
HLK68_04910	COG2223	nitrite transmembrane transporter activity
HLK68_04935	COG1357	PFAM Pentapeptide repeats (8 copies)
HLK68_04950	COG0786	glutamate:sodium symporter activity
HLK68_04955	COG0561	phosphatase activity
HLK68_04965	COG2814	Major facilitator Superfamily
HLK68_04990	COG3263	regulation of cellular component size
HLK68_05015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLK68_05020	COG0739	heme binding
HLK68_05025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLK68_05030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK68_05035	COG0187	DNA topoisomerase II activity
HLK68_05040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLK68_05045	COG2501	S4 domain
HLK68_05050	COG4481	Protein conserved in bacteria
HLK68_05055	COG0668	transmembrane transport
HLK68_05060	COG1475	DNA binding
HLK68_05065	COG1192	Involved in chromosome partitioning
HLK68_05070	COG1475	DNA binding
HLK68_05085	COG4152	abc transporter atp-binding protein
HLK68_05090	COG1668	transmembrane transport
HLK68_05095	COG0592	DNA-directed DNA polymerase activity
HLK68_05120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLK68_05130	COG2502	aspartate--ammonia ligase
HLK68_05135	COG0017	Asparaginyl-tRNA synthetase
HLK68_05160	COG1523	belongs to the glycosyl hydrolase 13 family
HLK68_05175	COG0018	arginyl-trna synthetase
HLK68_05205	COG0504	CTP synthase activity
HLK68_05215	COG3706	GGDEF domain
HLK68_05220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HLK68_05240	COG0745	RESPONSE REGULATOR receiver
HLK68_05245	COG2770	Histidine kinase
HLK68_05245	COG2205	protein histidine kinase activity
HLK68_05250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLK68_05255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK68_05260	COG3620	sequence-specific DNA binding
HLK68_05265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLK68_05270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLK68_05285	COG1501	Belongs to the glycosyl hydrolase 31 family
HLK68_05310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLK68_05320	COG0366	Alpha amylase catalytic
HLK68_05330	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLK68_05355	COG2202	Pas domain
HLK68_05355	COG2200	EAL domain
HLK68_05355	COG2199	diguanylate cyclase activity
HLK68_05365	COG1595	DNA-templated transcription, initiation
HLK68_05375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLK68_05380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLK68_05395	COG0475	glutathione-regulated potassium exporter activity
HLK68_05405	COG1494	fructose-1,6-bisphosphatase
HLK68_05410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLK68_05420	COG1695	Transcriptional regulator
HLK68_05435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLK68_05455	COG0251	oxidation-reduction process
HLK68_05460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLK68_05465	COG0215	cysteine-tRNA ligase activity
HLK68_05470	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HLK68_05475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK68_05485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK68_05490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLK68_05500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLK68_05505	COG0081	regulation of translation
HLK68_05510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLK68_05515	COG0222	ribosome binding
HLK68_05520	COG2813	Specifically methylates the guanine in position
HLK68_05525	COG0085	RNA polymerase activity
HLK68_05530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLK68_05535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLK68_05540	COG0049	tRNA binding
HLK68_05550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLK68_05555	COG0051	transcription antitermination factor activity, RNA binding
HLK68_05565	COG0088	Forms part of the polypeptide exit tunnel
HLK68_05570	COG0089	rRNA binding
HLK68_05575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLK68_05580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLK68_05585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLK68_05590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLK68_05595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLK68_05600	COG0255	Belongs to the universal ribosomal protein uL29 family
HLK68_05610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLK68_05625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLK68_05630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLK68_05640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HLK68_05645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLK68_05650	COG1841	ribosomal large subunit assembly
HLK68_05660	COG0201	protein transport
HLK68_05665	COG0563	adenylate kinase activity
HLK68_05670	COG0024	Methionine aminopeptidase
HLK68_05680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLK68_05690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HLK68_05695	COG0202	RNA polymerase activity
HLK68_05705	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLK68_05715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK68_05720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLK68_05725	COG1846	Transcriptional regulator
HLK68_05730	COG0534	Mate efflux family protein
HLK68_05745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HLK68_05750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK68_05765	COG4485	Bacterial membrane protein, YfhO
HLK68_05775	COG2267	carboxylic ester hydrolase activity
HLK68_05780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLK68_05790	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLK68_05795	COG0561	phosphatase activity
HLK68_05810	COG1058	Belongs to the CinA family
HLK68_05810	COG1546	Belongs to the CinA family
HLK68_05820	COG0149	triose-phosphate isomerase activity
HLK68_05830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK68_05835	COG5658	integral membrane protein
HLK68_05845	COG2188	Transcriptional regulator
HLK68_05850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK68_05870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLK68_05875	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_05885	COG3859	Proton-coupled thiamine transporter YuaJ
HLK68_05890	COG1278	Cold shock
HLK68_05920	COG0561	phosphatase activity
HLK68_05930	COG1609	Transcriptional regulator
HLK68_05935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_05935	COG1263	PTS System
HLK68_05940	COG1621	beta-fructofuranosidase activity
HLK68_05945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLK68_05950	COG2239	Acts as a magnesium transporter
HLK68_05955	COG0745	RESPONSE REGULATOR receiver
HLK68_05960	COG5002	protein histidine kinase activity
HLK68_05965	COG2183	response to ionizing radiation
HLK68_05980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLK68_05985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLK68_05995	COG1686	Belongs to the peptidase S11 family
HLK68_06005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLK68_06040	COG1309	transcriptional regulator
HLK68_06045	COG0778	Nitroreductase
HLK68_06055	COG4894	glucomannan catabolic process
HLK68_06070	COG1136	(ABC) transporter
HLK68_06070	COG0577	efflux transmembrane transporter activity
HLK68_06085	COG0745	RESPONSE REGULATOR receiver
HLK68_06090	COG2205	protein histidine kinase activity
HLK68_06095	COG1592	Rubrerythrin
HLK68_06115	COG1472	Belongs to the glycosyl hydrolase 3 family
HLK68_06130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLK68_06140	COG1737	Transcriptional regulator
HLK68_06150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLK68_06165	COG1131	(ABC) transporter
HLK68_06170	COG1428	Deoxynucleoside kinase
HLK68_06175	COG3344	reverse transcriptase
HLK68_06185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLK68_06195	COG3655	Transcriptional regulator
HLK68_06205	COG3118	belongs to the thioredoxin family
HLK68_06230	COG3620	sequence-specific DNA binding
HLK68_06240	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK68_06250	COG2207	Transcriptional regulator
HLK68_06255	COG0667	Aldo Keto reductase
HLK68_06260	COG0456	acetyltransferase
HLK68_06265	COG0745	RESPONSE REGULATOR receiver
HLK68_06270	COG0642	Histidine kinase
HLK68_06280	COG0577	efflux transmembrane transporter activity
HLK68_06280	COG1136	(ABC) transporter
HLK68_06290	COG0577	efflux transmembrane transporter activity
HLK68_06290	COG1136	(ABC) transporter
HLK68_06300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLK68_06305	COG1328	CTP reductase activity
HLK68_06315	COG0733	neurotransmitter:sodium symporter activity
HLK68_06320	COG1114	Component of the transport system for branched-chain amino acids
HLK68_06345	COG2188	Transcriptional regulator
HLK68_06350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLK68_06360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_06360	COG1263	PTS System
HLK68_06370	COG3142	Participates in the control of copper homeostasis
HLK68_06385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK68_06390	COG1288	antiporter activity
HLK68_06395	COG1473	amidohydrolase
HLK68_06400	COG0628	permease
HLK68_06410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLK68_06455	COG0511	ligase activity, forming carbon-carbon bonds
HLK68_06460	COG0439	Biotin carboxylase
HLK68_06465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLK68_06480	COG2070	2-Nitropropane dioxygenase
HLK68_06485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLK68_06490	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_06495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLK68_06500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLK68_06510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLK68_06515	COG0739	heme binding
HLK68_06585	COG0802	atpase or kinase
HLK68_06590	COG1214	PFAM Peptidase M22, glycoprotease
HLK68_06610	COG0488	(ABC) transporter
HLK68_06615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HLK68_06625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLK68_06635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLK68_06640	COG0459	protein refolding
HLK68_06645	COG0736	holo-[acyl-carrier-protein] synthase activity
HLK68_06650	COG2155	Conserved Protein
HLK68_06655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLK68_06665	COG0745	RESPONSE REGULATOR receiver
HLK68_06670	COG5002	protein histidine kinase activity
HLK68_06675	COG0436	Aminotransferase
HLK68_06685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_06690	COG2137	regulation of response to DNA damage stimulus
HLK68_06695	COG2188	Transcriptional regulator
HLK68_06710	COG0366	Alpha amylase catalytic
HLK68_06715	COG0739	heme binding
HLK68_06720	COG4536	flavin adenine dinucleotide binding
HLK68_06730	COG0463	Glycosyl transferase, family 2
HLK68_06740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLK68_06745	COG1597	lipid kinase activity
HLK68_06750	COG5263	repeat protein
HLK68_06750	COG4193	domain, Protein
HLK68_06760	COG1216	Glycosyl transferase, family 2
HLK68_06760	COG1442	glycosyl transferase family 8
HLK68_06765	COG1442	glycosyl transferase family 8
HLK68_06765	COG1216	Glycosyl transferase, family 2
HLK68_06775	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_06790	COG3955	Domain of unknown function (DUF1919)
HLK68_06795	COG1215	transferase activity, transferring glycosyl groups
HLK68_06805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK68_06855	COG2801	Transposase and inactivated derivatives
HLK68_06875	COG5263	repeat protein
HLK68_06875	COG4193	domain, Protein
HLK68_06890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLK68_06895	COG0210	DNA helicase
HLK68_06900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK68_06910	COG0784	Response regulator, receiver
HLK68_06910	COG2205	protein histidine kinase activity
HLK68_06915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLK68_06925	COG1950	PFAM Membrane protein of
HLK68_06935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLK68_06940	COG0546	phosphoglycolate phosphatase activity
HLK68_06965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLK68_06970	COG1481	regulation of sporulation
HLK68_06985	COG0148	phosphopyruvate hydratase activity
HLK68_06990	COG0628	permease
HLK68_06995	COG0530	calcium, potassium:sodium antiporter activity
HLK68_07005	COG0557	exoribonuclease II activity
HLK68_07010	COG2843	Capsule synthesis protein
HLK68_07015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLK68_07050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK68_07055	COG1116	anion transmembrane transporter activity
HLK68_07060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLK68_07065	COG3842	ATPase activity
HLK68_07070	COG1175	transmembrane transport
HLK68_07075	COG0395	ABC-type sugar transport system, permease component
HLK68_07080	COG1653	transport
HLK68_07085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLK68_07090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLK68_07105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK68_07110	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HLK68_07115	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLK68_07120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK68_07140	COG1272	protein, Hemolysin III
HLK68_07150	COG3681	Belongs to the UPF0597 family
HLK68_07155	COG2268	Band 7 protein
HLK68_07170	COG0628	permease
HLK68_07185	COG2217	Heavy metal translocating P-type atpase
HLK68_07195	COG5002	protein histidine kinase activity
HLK68_07205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_07215	COG0583	DNA-binding transcription factor activity
HLK68_07220	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLK68_07235	COG1233	COG1233 Phytoene dehydrogenase and related
HLK68_07245	COG0534	Mate efflux family protein
HLK68_07255	COG5002	protein histidine kinase activity
HLK68_07265	COG1937	Protein conserved in bacteria
HLK68_07275	COG2608	mercury ion transmembrane transporter activity
HLK68_07290	COG1136	(ABC) transporter
HLK68_07295	COG0577	efflux transmembrane transporter activity
HLK68_07305	COG1131	(ABC) transporter
HLK68_07325	COG5002	protein histidine kinase activity
HLK68_07330	COG3711	transcriptional antiterminator
HLK68_07340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_07340	COG2190	(PTS) system
HLK68_07340	COG1263	PTS System
HLK68_07345	COG2723	6-phospho-beta-galactosidase activity
HLK68_07370	COG0534	Mate efflux family protein
HLK68_07380	COG0590	tRNA wobble adenosine to inosine editing
HLK68_07400	COG1234	tRNA 3'-trailer cleavage
HLK68_07405	COG0346	lactoylglutathione lyase activity
HLK68_07425	COG0277	FAD linked oxidase domain protein
HLK68_07430	COG0534	Mate efflux family protein
HLK68_07435	COG2033	superoxide reductase activity
HLK68_07450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLK68_07465	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HLK68_07475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_07480	COG1120	ATPase activity
HLK68_07500	COG2364	Membrane
HLK68_07505	COG2207	Transcriptional regulator
HLK68_07525	COG1136	(ABC) transporter
HLK68_07545	COG3153	acetyltransferase
HLK68_07560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLK68_07580	COG0431	NADPH-dependent FMN reductase
HLK68_07580	COG3976	FMN-binding domain protein
HLK68_07580	COG1053	succinate dehydrogenase
HLK68_07595	COG0515	serine threonine protein kinase
HLK68_07595	COG2815	serine threonine protein kinase
HLK68_07605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLK68_07610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HLK68_07620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLK68_07640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLK68_07660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_07665	COG1120	ATPase activity
HLK68_07690	COG1285	pathogenesis
HLK68_07705	COG1061	Type III restriction enzyme res subunit
HLK68_07710	COG0494	nUDIX hydrolase
HLK68_07755	COG2985	domain, Protein
HLK68_07760	COG0785	Cytochrome C biogenesis protein
HLK68_07775	COG4592	Periplasmic binding protein
HLK68_07780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_07785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_07790	COG1120	ATPase activity
HLK68_07795	COG2814	Major facilitator Superfamily
HLK68_07810	COG0019	diaminopimelate decarboxylase activity
HLK68_07815	COG0527	aspartate kinase activity
HLK68_07820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLK68_07825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK68_07830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLK68_07835	COG2171	N-acyltransferase activity
HLK68_07840	COG0789	Transcriptional regulator
HLK68_07845	COG0656	L-ascorbic acid biosynthetic process
HLK68_07850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLK68_07850	COG0517	IMP dehydrogenase activity
HLK68_07860	COG2723	6-phospho-beta-galactosidase activity
HLK68_07885	COG0583	DNA-binding transcription factor activity
HLK68_07890	COG3300	MHYT domain
HLK68_07890	COG5001	Diguanylate cyclase
HLK68_07910	COG2003	Belongs to the UPF0758 family
HLK68_07915	COG4512	PFAM Accessory gene regulator B
HLK68_07940	COG2003	Belongs to the UPF0758 family
HLK68_07970	COG0577	efflux transmembrane transporter activity
HLK68_07970	COG1136	(ABC) transporter
HLK68_07995	COG2003	Belongs to the UPF0758 family
HLK68_08080	COG1401	restriction endodeoxyribonuclease activity
HLK68_08095	COG2003	Belongs to the UPF0758 family
HLK68_08125	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLK68_08140	COG2003	Belongs to the UPF0758 family
HLK68_08230	COG0583	DNA-binding transcription factor activity
HLK68_08245	COG0067	glutamate synthase
HLK68_08245	COG0069	glutamate synthase activity
HLK68_08245	COG0070	glutamate synthase
HLK68_08265	COG1533	DNA photolyase activity
HLK68_08275	COG1316	TRANSCRIPTIONal
HLK68_08280	COG0826	peptidase U32
HLK68_08285	COG2323	membrane
HLK68_08290	COG0037	tRNA processing
HLK68_08315	COG1393	Belongs to the ArsC family
HLK68_08325	COG3557	Belongs to the UPF0374 family
HLK68_08435	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_08440	COG1175	transmembrane transport
HLK68_08445	COG3833	ABC-type maltose transport systems, permease component
HLK68_08450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLK68_08460	COG3620	sequence-specific DNA binding
HLK68_08475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK68_08540	COG1192	Involved in chromosome partitioning
HLK68_08555	COG0110	maltose O-acetyltransferase activity
HLK68_08570	COG2205	protein histidine kinase activity
HLK68_08575	COG0745	RESPONSE REGULATOR receiver
HLK68_08590	COG3620	sequence-specific DNA binding
HLK68_08600	COG1131	(ABC) transporter
HLK68_08615	COG1609	Transcriptional regulator
HLK68_08620	COG1263	PTS System
HLK68_08620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_08625	COG1621	beta-fructofuranosidase activity
HLK68_08670	COG1175	transmembrane transport
HLK68_08675	COG0395	ABC-type sugar transport system, permease component
HLK68_08680	COG1486	melibiose metabolic process
HLK68_08690	COG2211	Major facilitator Superfamily
HLK68_08695	COG0297	glycogen (starch) synthase activity
HLK68_08700	COG0024	Methionine aminopeptidase
HLK68_08710	COG3250	beta-galactosidase activity
HLK68_08715	COG3250	beta-galactosidase activity
HLK68_08720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_08735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLK68_08750	COG1609	Transcriptional regulator
HLK68_08755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLK68_08760	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HLK68_08765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK68_08780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLK68_08790	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK68_08820	COG0006	proline dipeptidase activity
HLK68_08825	COG5398	heme oxygenase
HLK68_08840	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLK68_08845	COG0396	ATPase activity
HLK68_08850	COG0719	Fe-S assembly protein
HLK68_08855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLK68_08860	COG0822	iron-sulfur transferase activity
HLK68_08865	COG0719	Fe-S assembly protein
HLK68_08875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HLK68_08880	COG3377	Domain of unknown function (DUF1805)
HLK68_08890	COG1136	(ABC) transporter
HLK68_08895	COG0577	efflux transmembrane transporter activity
HLK68_08895	COG1136	(ABC) transporter
HLK68_08910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK68_08915	COG0297	glycogen (starch) synthase activity
HLK68_08920	COG0058	SHG alpha-glucan phosphorylase activity
HLK68_08945	COG1595	DNA-templated transcription, initiation
HLK68_08960	COG0641	radical SAM
HLK68_08965	COG3119	arylsulfatase activity
HLK68_08965	COG3408	Glycogen debranching enzyme
HLK68_08975	COG1061	Type III restriction enzyme res subunit
HLK68_08995	COG1653	transport
HLK68_09000	COG0613	PHP domain protein
HLK68_09010	COG1592	Rubrerythrin
HLK68_09035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLK68_09065	COG4667	esterase of the alpha-beta hydrolase superfamily
HLK68_09075	COG0242	peptide deformylase activity
HLK68_09080	COG0842	Transport permease protein
HLK68_09090	COG1131	(ABC) transporter
HLK68_09095	COG2197	response regulator
HLK68_09100	COG4585	Histidine kinase
HLK68_09125	COG0210	DNA helicase
HLK68_09145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK68_09150	COG2011	ABC-type metal ion transport system permease component
HLK68_09155	COG1464	Belongs to the NlpA lipoprotein family
HLK68_09175	COG2985	domain, Protein
HLK68_09180	COG2078	PFAM AMMECR1 domain protein
HLK68_09180	COG3885	ferrous iron binding
HLK68_09205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_09210	COG1473	amidohydrolase
HLK68_09225	COG1609	Transcriptional regulator
HLK68_09230	COG1263	PTS System
HLK68_09230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_09235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_09240	COG1621	beta-fructofuranosidase activity
HLK68_09250	COG2059	Chromate
HLK68_09255	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_09265	COG3706	GGDEF domain
HLK68_09270	COG0513	Belongs to the DEAD box helicase family
HLK68_09275	COG2364	Membrane
HLK68_09280	COG1523	belongs to the glycosyl hydrolase 13 family
HLK68_09290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK68_09295	COG3481	metal-dependent phosphohydrolase, HD sub domain
HLK68_09300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLK68_09335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLK68_09375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK68_09385	COG0302	gtp cyclohydrolase
HLK68_09390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLK68_09395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLK68_09400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLK68_09405	COG0457	Tetratricopeptide repeat
HLK68_09410	COG2738	Putative neutral zinc metallopeptidase
HLK68_09415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK68_09425	COG0617	tRNA 3'-terminal CCA addition
HLK68_09435	COG3935	DnaD domain protein
HLK68_09440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLK68_09445	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLK68_09445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK68_09465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLK68_09470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLK68_09475	COG1418	mRNA catabolic process
HLK68_09480	COG1692	metallophosphoesterase
HLK68_09485	COG2359	stage V sporulation protein S
HLK68_09490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK68_09505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLK68_09510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLK68_09515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLK68_09520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK68_09550	COG3763	UPF0154 protein
HLK68_09560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLK68_09565	COG0187	DNA topoisomerase II activity
HLK68_09570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK68_09585	COG1702	phosphate starvation-inducible protein PhoH
HLK68_09590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLK68_09595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLK68_09600	COG0295	cytidine deaminase activity
HLK68_09615	COG1381	Involved in DNA repair and RecF pathway recombination
HLK68_09620	COG0423	glycine-tRNA ligase activity
HLK68_09625	COG0358	DNA primase activity
HLK68_09630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK68_09635	COG2384	SAM-dependent methyltransferase
HLK68_09640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLK68_09645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLK68_09650	COG0072	phenylalanine-tRNA ligase activity
HLK68_09650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLK68_09655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLK68_09655	COG1605	Chorismate mutase
HLK68_09660	COG1609	Transcriptional regulator
HLK68_09670	COG1917	Cupin 2, conserved barrel domain protein
HLK68_09670	COG4977	sequence-specific DNA binding
HLK68_09685	COG0583	DNA-binding transcription factor activity
HLK68_09695	COG1956	GAF domain-containing protein
HLK68_09705	COG1104	cysteine desulfurase activity
HLK68_09710	COG0301	tRNA thio-modification
HLK68_09715	COG1012	belongs to the aldehyde dehydrogenase family
HLK68_09715	COG1454	alcohol dehydrogenase
HLK68_09720	COG1136	(ABC) transporter
HLK68_09725	COG0577	efflux transmembrane transporter activity
HLK68_09750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK68_09755	COG0779	Required for maturation of 30S ribosomal subunits
HLK68_09760	COG0195	Participates in both transcription termination and antitermination
HLK68_09765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HLK68_09770	COG1358	cellular component organization or biogenesis
HLK68_09775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLK68_09780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLK68_09790	COG0322	excinuclease ABC activity
HLK68_09795	COG2197	response regulator
HLK68_09810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLK68_09820	COG0622	Phosphoesterase
HLK68_09850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK68_09850	COG0551	DNA topoisomerase type I activity
HLK68_09860	COG0583	DNA-binding transcription factor activity
HLK68_09890	COG0569	domain protein
HLK68_09925	COG1476	TRANSCRIPTIONal
HLK68_09930	COG4086	secreted protein
HLK68_09970	COG0561	phosphatase activity
HLK68_09980	COG0242	peptide deformylase activity
HLK68_10015	COG0772	Belongs to the SEDS family
HLK68_10035	COG4471	UPF0298 protein
HLK68_10040	COG0228	four-way junction DNA binding
HLK68_10045	COG1837	Belongs to the UPF0109 family
HLK68_10080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HLK68_10085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLK68_10095	COG0181	hydroxymethylbilane synthase activity
HLK68_10105	COG0113	porphobilinogen synthase activity
HLK68_10110	COG1648	precorrin-2 dehydrogenase activity
HLK68_10110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLK68_10115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK68_10120	COG0765	amino acid transport
HLK68_10125	COG1126	abc transporter atp-binding protein
HLK68_10135	COG2222	sugar isomerase
HLK68_10145	COG2972	Histidine kinase
HLK68_10150	COG4753	response regulator
HLK68_10150	COG2207	Transcriptional regulator
HLK68_10195	COG1175	transmembrane transport
HLK68_10200	COG0395	ABC-type sugar transport system, permease component
HLK68_10205	COG5426	von Willebrand factor, type A
HLK68_10230	COG1846	Transcriptional regulator
HLK68_10235	COG0386	Belongs to the glutathione peroxidase family
HLK68_10240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK68_10245	COG1664	Polymer-forming cytoskeletal
HLK68_10245	COG1664	Polymer-forming cytoskeletal
HLK68_10250	COG1664	Polymer-forming cytoskeletal
HLK68_10260	COG0789	Transcriptional regulator
HLK68_10265	COG1132	(ABC) transporter
HLK68_10285	COG0561	phosphatase activity
HLK68_10350	COG1929	Belongs to the glycerate kinase type-1 family
HLK68_10355	COG2610	gluconate transmembrane transporter activity
HLK68_10360	COG1842	Phage shock protein A
HLK68_10370	COG4260	virion core protein, lumpy skin disease virus
HLK68_10390	COG2244	polysaccharide biosynthetic process
HLK68_10405	COG1187	pseudouridine synthase activity
HLK68_10410	COG0613	PHP domain protein
HLK68_10420	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLK68_10430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK68_10435	COG1674	ftsk spoiiie
HLK68_10440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLK68_10465	COG0489	protein tyrosine kinase activity
HLK68_10470	COG1323	Belongs to the UPF0348 family
HLK68_10475	COG1399	metal-binding, possibly nucleic acid-binding protein
HLK68_10480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLK68_10495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLK68_10500	COG0513	Belongs to the DEAD box helicase family
HLK68_10505	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HLK68_10525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLK68_10550	COG1940	carbohydrate kinase activity
HLK68_10555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK68_10565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLK68_10585	COG4970	Tfp pilus assembly protein FimT
HLK68_10590	COG4537	Required for transformation and DNA binding
HLK68_10595	COG1459	type II secretion system
HLK68_10600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLK68_10625	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HLK68_10630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLK68_10680	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK68_10690	COG0004	ammonium transporteR
HLK68_10705	COG0658	competence protein
HLK68_10705	COG2333	competence protein COMEC
HLK68_10710	COG4166	transmembrane transport
HLK68_10715	COG0488	(ABC) transporter
HLK68_10730	COG1199	ATP-dependent helicase activity
HLK68_10735	COG1846	Transcriptional regulator
HLK68_10740	COG1132	(ABC) transporter
HLK68_10745	COG1132	(ABC) transporter
HLK68_10750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK68_10755	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK68_10760	COG0681	Belongs to the peptidase S26 family
HLK68_10765	COG0564	pseudouridine synthase activity
HLK68_10805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK68_10820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK68_10850	COG2153	protein acetylation
HLK68_10865	COG0312	modulator of DNA gyrase
HLK68_10870	COG0312	modulator of DNA gyrase
HLK68_10880	COG4988	ABC transporter
HLK68_10885	COG1132	(ABC) transporter
HLK68_10895	COG2832	Protein of unknown function (DUF454)
HLK68_10930	COG0243	molybdopterin cofactor binding
HLK68_10955	COG1979	alcohol dehydrogenase
HLK68_10960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLK68_10970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLK68_10990	COG1263	PTS System
HLK68_10990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_10990	COG2190	(PTS) system
HLK68_11020	COG2205	protein histidine kinase activity
HLK68_11040	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK68_11055	COG0488	(ABC) transporter
HLK68_11065	COG0110	maltose O-acetyltransferase activity
HLK68_11080	COG1268	BioY protein
HLK68_11095	COG0494	nUDIX hydrolase
HLK68_11115	COG0303	'Molybdopterin
HLK68_11125	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLK68_11130	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLK68_11135	COG4149	molybdate abc transporter
HLK68_11145	COG0315	cyclic pyranopterin monophosphate synthase activity
HLK68_11155	COG2258	MOSC domain
HLK68_11165	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLK68_11180	COG1187	pseudouridine synthase activity
HLK68_11200	COG4807	Protein conserved in bacteria
HLK68_11210	COG1368	sulfuric ester hydrolase activity
HLK68_11250	COG0110	maltose O-acetyltransferase activity
HLK68_11270	COG0110	maltose O-acetyltransferase activity
HLK68_11275	COG0561	phosphatase activity
HLK68_11280	COG0346	lactoylglutathione lyase activity
HLK68_11300	COG0252	asparaginase activity
HLK68_11305	COG0745	RESPONSE REGULATOR receiver
HLK68_11320	COG1132	(ABC) transporter
HLK68_11325	COG2378	regulation of single-species biofilm formation
HLK68_11330	COG1473	amidohydrolase
HLK68_11375	COG0745	RESPONSE REGULATOR receiver
HLK68_11380	COG5002	protein histidine kinase activity
HLK68_11395	COG1446	asparaginase
HLK68_11425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK68_11435	COG1349	DNA-binding transcription factor activity
HLK68_11440	COG1105	Belongs to the carbohydrate kinase PfkB family
HLK68_11445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_11445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_11445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_11470	COG0038	chloride channel
HLK68_11475	COG0708	Exodeoxyribonuclease III
HLK68_11480	COG5002	protein histidine kinase activity
HLK68_11485	COG0745	RESPONSE REGULATOR receiver
HLK68_11565	COG0640	Transcriptional regulator
HLK68_11570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLK68_11575	COG0534	Mate efflux family protein
HLK68_11600	COG0720	synthase
HLK68_11605	COG0602	queuosine metabolic process
HLK68_11610	COG0302	gtp cyclohydrolase
HLK68_11620	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLK68_11625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLK68_11635	COG0561	phosphatase activity
HLK68_11640	COG1803	Methylglyoxal synthase
HLK68_11650	COG0671	phosphoesterase, PA-phosphatase related
HLK68_11675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLK68_11690	COG4166	transmembrane transport
HLK68_11695	COG0601	transmembrane transport
HLK68_11700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK68_11705	COG0444	Belongs to the ABC transporter superfamily
HLK68_11740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLK68_11745	COG1570	exodeoxyribonuclease VII activity
HLK68_11755	COG0142	geranyltranstransferase activity
HLK68_11760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLK68_11765	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HLK68_11770	COG0497	DNA recombination
HLK68_11775	COG0750	zinc metalloprotease
HLK68_11780	COG0745	RESPONSE REGULATOR receiver
HLK68_11785	COG1649	PFAM Uncharacterised BCR, COG1649
HLK68_11795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK68_11810	COG0735	belongs to the Fur family
HLK68_11815	COG4974	Belongs to the 'phage' integrase family
HLK68_11825	COG1827	regulation of RNA biosynthetic process
HLK68_11835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_11840	COG0366	Alpha amylase catalytic
HLK68_11845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_11845	COG1263	PTS System
HLK68_11845	COG2190	(PTS) system
HLK68_11880	COG0366	Alpha amylase catalytic
HLK68_11910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLK68_11915	COG3326	Membrane
HLK68_11925	COG2132	Multicopper oxidase
HLK68_11930	COG2827	Endonuclease containing a URI domain
HLK68_11940	COG1737	Transcriptional regulator
HLK68_11950	COG1175	transmembrane transport
HLK68_11955	COG0395	ABC-type sugar transport system, permease component
HLK68_11960	COG0534	Mate efflux family protein
HLK68_11970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK68_11985	COG0737	Belongs to the 5'-nucleotidase family
HLK68_12055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLK68_12060	COG1115	amino acid carrier protein
HLK68_12070	COG1307	EDD domain protein, DegV family
HLK68_12075	COG1671	Belongs to the UPF0178 family
HLK68_12080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_12085	COG4129	membrane
HLK68_12100	COG1550	Protein conserved in bacteria
HLK68_12105	COG0628	permease
HLK68_12115	COG0534	Mate efflux family protein
HLK68_12120	COG1522	sequence-specific DNA binding
HLK68_12125	COG0436	Aminotransferase
HLK68_12130	COG0534	Mate efflux family protein
HLK68_12140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK68_12150	COG4377	Putative membrane peptidase family (DUF2324)
HLK68_12155	COG0640	Transcriptional regulator
HLK68_12170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_12200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK68_12205	COG0180	Tryptophanyl-tRNA synthetase
HLK68_12220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLK68_12230	COG0473	3-isopropylmalate dehydrogenase activity
HLK68_12235	COG2226	methyltransferase
HLK68_12270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_12275	COG3715	PTS system
HLK68_12280	COG3716	PTS system mannose fructose sorbose family IID component
HLK68_12295	COG3546	catalase activity
HLK68_12300	COG3546	catalase activity
HLK68_12330	COG1132	(ABC) transporter
HLK68_12340	COG2205	protein histidine kinase activity
HLK68_12340	COG2202	Pas domain
HLK68_12345	COG1331	Highly conserved protein containing a thioredoxin domain
HLK68_12395	COG1061	Type III restriction enzyme res subunit
HLK68_12420	COG0656	L-ascorbic acid biosynthetic process
HLK68_12435	COG0667	Aldo Keto reductase
HLK68_12470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK68_12480	COG4565	transcriptional regulatory protein
HLK68_12490	COG0667	Aldo Keto reductase
HLK68_12510	COG1363	Peptidase, m42
HLK68_12515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLK68_12540	COG0534	Mate efflux family protein
HLK68_12565	COG0561	phosphatase activity
HLK68_12585	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_12590	COG0367	asparagine synthase
HLK68_12600	COG2357	RelA SpoT domain protein
HLK68_12605	COG0252	asparaginase activity
HLK68_12615	COG1122	ATPase activity
HLK68_12620	COG4120	Belongs to the binding-protein-dependent transport system permease family
HLK68_12630	COG0723	plastoquinol--plastocyanin reductase activity
HLK68_12630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK68_12655	COG0733	neurotransmitter:sodium symporter activity
HLK68_12685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLK68_12690	COG0010	Belongs to the arginase family
HLK68_12695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HLK68_12700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HLK68_12705	COG1982	Orn Lys Arg decarboxylase major
HLK68_12735	COG4974	Belongs to the 'phage' integrase family
HLK68_12755	COG1523	belongs to the glycosyl hydrolase 13 family
HLK68_12770	COG0534	Mate efflux family protein
HLK68_12775	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_12785	COG0800	Aldolase
HLK68_12805	COG2721	sulfolactate sulfo-lyase activity
HLK68_12810	COG0246	Mannitol dehydrogenase
HLK68_12815	COG1904	glucuronate isomerase
HLK68_12830	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK68_12835	COG0395	ABC-type sugar transport system, permease component
HLK68_12840	COG1175	transmembrane transport
HLK68_12875	COG4720	Psort location CytoplasmicMembrane, score
HLK68_12880	COG2081	HI0933 family
HLK68_12905	COG1177	transmembrane transport
HLK68_12910	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK68_12915	COG3842	ATPase activity
HLK68_12935	COG1466	dna polymerase III delta subunit
HLK68_12940	COG2333	competence protein COMEC
HLK68_12940	COG0658	competence protein
HLK68_12945	COG1555	photosystem II stabilization
HLK68_12945	COG1596	polysaccharide export
HLK68_12955	COG2226	methyltransferase
HLK68_12960	COG0799	negative regulation of ribosome biogenesis
HLK68_12965	COG1713	HD superfamily hydrolase involved in NAD metabolism
HLK68_12970	COG1534	Rna-binding protein
HLK68_12980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLK68_12985	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLK68_12995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK68_12995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLK68_13000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLK68_13005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLK68_13010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLK68_13015	COG0572	uridine kinase
HLK68_13030	COG4122	O-methyltransferase activity
HLK68_13035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLK68_13040	COG3906	Belongs to the UPF0473 family
HLK68_13055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLK68_13065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLK68_13070	COG0482	sulfurtransferase activity
HLK68_13090	COG1744	ABC transporter substrate-binding protein PnrA-like
HLK68_13115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK68_13120	COG0527	aspartate kinase activity
HLK68_13125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLK68_13130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK68_13135	COG0726	polysaccharide deacetylase
HLK68_13140	COG1185	polyribonucleotide nucleotidyltransferase activity
HLK68_13145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLK68_13150	COG0196	riboflavin kinase activity
HLK68_13155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLK68_13160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK68_13170	COG0481	GTPase activity
HLK68_13185	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HLK68_13195	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK68_13210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLK68_13215	COG0268	Binds directly to 16S ribosomal RNA
HLK68_13255	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_13260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLK68_13265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK68_13270	COG1610	YqeY-like protein
HLK68_13275	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLK68_13290	COG2801	Transposase and inactivated derivatives
HLK68_13300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK68_13305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLK68_13310	COG2264	protein methyltransferase activity
HLK68_13315	COG0484	heat shock protein binding
HLK68_13320	COG0443	Heat shock 70 kDa protein
HLK68_13325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLK68_13330	COG1420	regulation of RNA biosynthetic process
HLK68_13335	COG3118	belongs to the thioredoxin family
HLK68_13345	COG0765	amino acid transport
HLK68_13350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK68_13355	COG1193	negative regulation of DNA recombination
HLK68_13360	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLK68_13365	COG0457	Tetratricopeptide repeat
HLK68_13365	COG0705	Rhomboid family
HLK68_13370	COG0564	pseudouridine synthase activity
HLK68_13375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLK68_13395	COG1695	Transcriptional regulator
HLK68_13400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLK68_13405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLK68_13415	COG2302	S4 RNA-binding domain
HLK68_13420	COG0762	integral membrane protein
HLK68_13425	COG1799	cell septum assembly
HLK68_13430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLK68_13435	COG1873	PFAM PRC-barrel domain
HLK68_13440	COG1191	sigma factor activity
HLK68_13445	COG1191	sigma factor activity
HLK68_13460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLK68_13465	COG0849	cell division
HLK68_13475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLK68_13480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_13485	COG0772	Belongs to the SEDS family
HLK68_13490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLK68_13495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK68_13500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLK68_13505	COG0768	penicillin binding
HLK68_13520	COG0275	rRNA processing
HLK68_13525	COG2001	Belongs to the MraZ family
HLK68_13535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLK68_13540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLK68_13545	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLK68_13595	COG3069	C4-dicarboxylate transmembrane transporter activity
HLK68_13605	COG0210	DNA helicase
HLK68_13625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK68_13630	COG0673	inositol 2-dehydrogenase activity
HLK68_13635	COG1114	Component of the transport system for branched-chain amino acids
HLK68_13650	COG0475	glutathione-regulated potassium exporter activity
HLK68_13670	COG1227	inorganic diphosphatase activity
HLK68_13680	COG2271	Major facilitator Superfamily
HLK68_13685	COG2267	carboxylic ester hydrolase activity
HLK68_13695	COG2176	DNA-directed DNA polymerase activity
HLK68_13705	COG0750	zinc metalloprotease
HLK68_13715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLK68_13735	COG0233	cytoplasmic translational termination
HLK68_13740	COG0528	UMP kinase activity
HLK68_13745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLK68_13755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK68_13760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK68_13775	COG4974	Belongs to the 'phage' integrase family
HLK68_13785	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HLK68_13795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK68_13800	COG0726	polysaccharide deacetylase
HLK68_13805	COG0758	DNA mediated transformation
HLK68_13830	COG0335	large ribosomal subunit rRNA binding
HLK68_13840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLK68_13845	COG2878	Part of a membrane complex involved in electron transport
HLK68_13855	COG4657	Part of a membrane complex involved in electron transport
HLK68_13860	COG4660	Part of a membrane complex involved in electron transport
HLK68_13870	COG4658	electron transport chain
HLK68_13875	COG4656	Part of a membrane complex involved in electron transport
HLK68_13905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLK68_13910	COG0742	ribosomal rna small subunit methyltransferase
HLK68_13930	COG1785	Belongs to the alkaline phosphatase family
HLK68_13935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLK68_13940	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HLK68_13945	COG0552	protein localization to endoplasmic reticulum
HLK68_13950	COG1196	nuclear chromosome segregation
HLK68_13975	COG1012	belongs to the aldehyde dehydrogenase family
HLK68_14030	COG1115	amino acid carrier protein
HLK68_14075	COG0463	Glycosyl transferase, family 2
HLK68_14120	COG1595	DNA-templated transcription, initiation
HLK68_14145	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HLK68_14160	COG0419	ATPase involved in DNA repair
HLK68_14165	COG0420	3'-5' exonuclease activity
HLK68_14170	COG1609	Transcriptional regulator
HLK68_14205	COG0300	oxidoreductase activity
HLK68_14220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLK68_14225	COG1461	Dihydroxyacetone kinase
HLK68_14230	COG1302	Protein conserved in bacteria
HLK68_14235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLK68_14260	COG1564	THIamine pyrophosphokinase
HLK68_14265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK68_14270	COG1162	GTPase activity
HLK68_14275	COG0515	serine threonine protein kinase
HLK68_14275	COG2815	serine threonine protein kinase
HLK68_14280	COG0631	protein serine/threonine phosphatase activity
HLK68_14290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLK68_14290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLK68_14295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK68_14300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK68_14305	COG2996	Protein conserved in bacteria
HLK68_14320	COG0426	domain, Protein
HLK68_14325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK68_14335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLK68_14340	COG1758	RNA polymerase activity
HLK68_14345	COG0194	GDP metabolic process
HLK68_14355	COG2720	vancomycin resistance protein
HLK68_14365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK68_14380	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HLK68_14385	COG1876	peptidase activity
HLK68_14400	COG0772	Belongs to the SEDS family
HLK68_14405	COG1074	ATP-dependent DNA helicase activity
HLK68_14410	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HLK68_14420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLK68_14430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLK68_14435	COG1160	GTP binding
HLK68_14440	COG0539	negative regulation of cytoplasmic translation
HLK68_14445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLK68_14455	COG1141	Ferredoxin
HLK68_14460	COG1187	pseudouridine synthase activity
HLK68_14465	COG0700	Nucleoside recognition
HLK68_14470	COG2715	membrane protein required for spore maturation
HLK68_14475	COG1686	Belongs to the peptidase S11 family
HLK68_14485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLK68_14495	COG0697	spore germination
HLK68_14505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids