locus-tag class description Turpa_0001 ENOG4108KQ5 Integrase catalytic subunit Turpa_0004 ENOG41083X2 DNA polymerase III, epsilon subunit Turpa_0008 ENOG4107QJE Chromosome Partitioning Protein Turpa_0009 ENOG4105FA0 parb-like partition protein Turpa_0013 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) Turpa_0014 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) Turpa_0015 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) Turpa_0017 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Turpa_0019 ENOG4105CA0 peroxidase Turpa_0025 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Turpa_0026 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Turpa_0027 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Turpa_0028 ENOG4108Z03 MAF-like protein Turpa_0030 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Turpa_0033 ENOG4105CGK Exodeoxyribonuclease III Turpa_0037 ENOG4108ZQS transposase Turpa_0038 ENOG4108MVM Transposase Turpa_0042 ENOG4108J1Q Turpa_0053 ENOG4105DZR Type I site-specific deoxyribonuclease Turpa_0053 ENOG4105DZR Type I site-specific deoxyribonuclease Turpa_0055 ENOG4107QTH restriction modification system DNA specificity domain Turpa_0059 ENOG4105F9F transposase Turpa_0061 ENOG41082BE ankyrin repeat-containing protein Turpa_0066 ENOG4108J1Q Turpa_0067 ENOG4105FA0 parb-like partition protein Turpa_0084 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Turpa_0091 ENOG4106WTF Glycosyl transferase, family 2 Turpa_0092 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Turpa_0093 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Turpa_0097 ENOG4105C28 cystathionine Turpa_0099 ENOG4105BZU Histidine kinase Turpa_0100 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Turpa_0104 ENOG4105CSR polyphosphate kinase 2 Turpa_0107 ENOG4108IQE Amp-dependent synthetase and ligase Turpa_0108 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Turpa_0110 ENOG41063C6 UPF0235 protein Turpa_0115 ENOG4108YZG isomerase Turpa_0122 ENOG4105C9X ppx gppa phosphatase Turpa_0129 ENOG4107YU2 histidine triad (hIT) protein Turpa_0132 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) Turpa_0133 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Turpa_0139 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Turpa_0142 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Turpa_0144 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Turpa_0146 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Turpa_0148 ENOG4105CHR reductase Turpa_0156 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Turpa_0160 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Turpa_0162 ENOG4107QKA exodeoxyribonuclease V beta Turpa_0163 ENOG4107QYX exodeoxyribonuclease v alpha Turpa_0167 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Turpa_0171 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Turpa_0174 ENOG4107MKT Stringent starvation protein a Turpa_0175 ENOG4105JFG SpoIID LytB domain protein Turpa_0176 ENOG4108ZAI phosphatidylglycerophosphatase a Turpa_0179 ENOG4105D1S lipid A biosynthesis Turpa_0184 ENOG4105DA4 cytochrome c-type biogenesis protein Turpa_0185 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Turpa_0188 ENOG4105CPC Aldo Keto reductase Turpa_0189 ENOG4108VGI doxx family Turpa_0193 ENOG4105WN5 stage II sporulation protein Turpa_0197 ENOG4105DF6 Fe-S oxidoreductase Turpa_0198 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) Turpa_0199 ENOG4105CEY Amp-dependent synthetase and ligase Turpa_0202 ENOG4105CS2 ec 3.2.1.21 Turpa_0203 ENOG4107QWW Cell wall formation (By similarity) Turpa_0204 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Turpa_0208 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Turpa_0213 ENOG4105CNU cell division protein FtsK Turpa_0218 ENOG4105E02 MotA TolQ exbB proton channel Turpa_0219 ENOG4105M8F Biopolymer transport protein exbD tolR Turpa_0225 ENOG4105CVA phosphate Turpa_0229 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Turpa_0230 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase Turpa_0232 ENOG4108I5C dEAD DEAH box helicase Turpa_0235 ENOG4107UIY sua5 ycio yrdc ywlc family protein Turpa_0236 ENOG4105EMU Dehydrogenase Turpa_0238 ENOG4105C8T Leucyl-tRNA synthetase Turpa_0241 ENOG4108UUM single-stranded DNA-binding protein Turpa_0247 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Turpa_0248 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) Turpa_0251 ENOG4105C37 (CBS) domain Turpa_0252 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Turpa_0255 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Turpa_0258 ENOG4105CVP deoxyribo-dipyrimidine photolyase Turpa_0259 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Turpa_0262 ENOG4105CFH Aspartokinase Turpa_0263 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Turpa_0265 ENOG4105I03 Flagellin Turpa_0270 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Turpa_0276 ENOG4107R72 Ceramidase Turpa_0278 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) Turpa_0280 ENOG4105RFZ Methylmalonyl-coA mutase Turpa_0282 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Turpa_0284 ENOG4108NVM synthesis repressor PhaR Turpa_0285 ENOG4105F9F transposase Turpa_0287 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Turpa_0290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Turpa_0297 ENOG4105C1G acyl-Coa dehydrogenase Turpa_0300 ENOG4105C1B dTDP-glucose 4-6-dehydratase Turpa_0304 ENOG4105C6Y Udp-glucose 6-dehydrogenase Turpa_0308 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Turpa_0309 ENOG4107QQG Dehydrogenase Turpa_0311 ENOG4105J5G Transferase hexapeptide repeat containing protein Turpa_0312 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Turpa_0314 ENOG4105EY8 ABC transporter Turpa_0317 ENOG4105CAQ asparagine synthetase Turpa_0318 ENOG4105CMR udp-glucose 4-epimerase Turpa_0319 ENOG4105C1B dTDP-glucose 4-6-dehydratase Turpa_0323 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Turpa_0324 ENOG4105CAQ asparagine synthetase Turpa_0328 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Turpa_0331 ENOG4105F9F transposase Turpa_0334 ENOG4105CT4 transporter Turpa_0343 ENOG4105E18 UPF0276 protein Turpa_0348 ENOG4105C08 Histidine kinase Turpa_0350 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Turpa_0353 ENOG4105CUT histidyl-tRNA synthetase Turpa_0355 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Turpa_0360 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Turpa_0361 ENOG4105E0M Sulfatase Turpa_0370 ENOG4107IFA Lipase (EC 3.1.1.3) Turpa_0373 ENOG4105CY3 ABC transporter, permease Turpa_0375 ENOG4105D7W serine acetyltransferase Turpa_0378 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Turpa_0379 ENOG4105CQB FAD linked oxidase domain protein Turpa_0381 ENOG4105DXN mazG family Turpa_0389 ENOG4105BZP glycoside hydrolase 15-related Turpa_0390 ENOG4107R0U MotA TolQ exbB proton channel Turpa_0391 ENOG4107XSU flagellar motor protein motb Turpa_0394 ENOG4106MP8 UPF0754 membrane protein Turpa_0395 ENOG4107QYG anthranilate phosphoribosyltransferase Turpa_0399 ENOG4108HMX isocitrate dehydrogenase (NADP) Turpa_0400 ENOG4105CGU Enoyl-CoA hydratase Turpa_0402 ENOG4105C1G acyl-Coa dehydrogenase Turpa_0412 ENOG4105BZU Histidine kinase Turpa_0414 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Turpa_0418 ENOG4105CTQ phosphohexokinase Turpa_0419 ENOG4105E39 Enoyl-CoA hydratase Turpa_0420 ENOG4108N3W hemolysin secretion protein Turpa_0421 ENOG4105KME endoribonuclease L-psp Turpa_0422 ENOG4107QM5 aconitate hydratase Turpa_0424 ENOG4107SGM protein serine threonine phosphatase Turpa_0428 ENOG4105CI3 gtp-binding protein typa Turpa_0433 ENOG4105IJJ transcriptional regulator, crp fnr family Turpa_0435 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Turpa_0438 ENOG4108K5P (LipO)protein Turpa_0439 ENOG4105D2T synthase Turpa_0440 ENOG4105KRI phosphocarrier protein (HPr Turpa_0441 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Turpa_0446 ENOG4105BZU Histidine kinase Turpa_0448 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Turpa_0449 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Turpa_0450 ENOG4105BZU Histidine kinase Turpa_0452 ENOG4105EWT decarboxylase family Turpa_0455 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Turpa_0456 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Turpa_0460 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) Turpa_0461 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Turpa_0463 ENOG4105CE9 30S ribosomal protein S2 Turpa_0464 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Turpa_0466 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Turpa_0467 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Turpa_0469 ENOG4105DK0 Indole-3-glycerol phosphate synthase Turpa_0470 ENOG4105CJW magnesium transporter Turpa_0471 ENOG4105WD1 Membrane Turpa_0472 ENOG41084GC stage II sporulation protein Turpa_0477 ENOG4108S01 response regulator Turpa_0491 ENOG4105F9F transposase Turpa_0494 ENOG4105CN7 Flagellar biosynthetic protein FliP Turpa_0496 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Turpa_0502 ENOG4105WN5 stage II sporulation protein Turpa_0510 ENOG4105C26 Dehydrogenase Turpa_0512 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Turpa_0519 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Turpa_0527 ENOG41090HT Inherit from COG: transposase Turpa_0538 ENOG4105XDF Protein of unknown function (DUF1272) Turpa_0542 ENOG4108KPJ rna polymerase sigma factor Turpa_0551 ENOG4108J1Q Turpa_0556 ENOG4106H6R UPF0380 protein Turpa_0569 ENOG4107R3N Filamentation induced by cAMP protein fic Turpa_0570 ENOG4108F3G Type I restriction-modification system, R subunit Turpa_0573 ENOG4108J1Q Turpa_0580 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Turpa_0581 ENOG4108JQC penicillin-binding protein 1A Turpa_0582 ENOG4105CS7 Catalyzes the conversion of dihydroorotate to orotate Turpa_0586 ENOG4107RN3 metallophosphoesterase Turpa_0588 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Turpa_0590 ENOG4105DZP Membrane-associated zinc metalloprotease Turpa_0596 ENOG4105CA0 peroxidase Turpa_0603 ENOG4108HU6 Metal dependent phosphohydrolase Turpa_0606 ENOG4105VFU Rna-binding protein Turpa_0607 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Turpa_0609 ENOG4108ZVA radical SAM domain protein Turpa_0611 ENOG4105BZ4 penicillin-binding protein Turpa_0613 ENOG4105EDV vault protein Turpa_0614 ENOG41073R8 VanW family Turpa_0615 ENOG4107S52 alpha-2-macroglobulin domain protein Turpa_0619 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) Turpa_0621 ENOG4105WH1 Two component transcriptional regulator luxr family Turpa_0622 ENOG4105BZU Histidine kinase Turpa_0624 ENOG4105C2N RNA methyltransferase TrmH family group 3 Turpa_0625 ENOG4105C8N cysteinyl-tRNA synthetase Turpa_0626 ENOG4105EUJ GTP cyclohydrolase i Turpa_0629 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Turpa_0637 ENOG4105C59 p-type ATPase Turpa_0644 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Turpa_0645 ENOG4107RE7 phosphate butyryltransferase Turpa_0648 ENOG4105EIE fructose-bisphosphate aldolase Turpa_0651 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Turpa_0652 ENOG4105K63 Thioredoxin Turpa_0654 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Turpa_0658 ENOG4105C83 adenylosuccinate lyase Turpa_0659 ENOG41082AN stage II sporulation protein Turpa_0663 ENOG4105DWV Homoserine O-trans-acetylase Turpa_0671 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Turpa_0672 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Turpa_0673 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Turpa_0676 ENOG4105CEY Amp-dependent synthetase and ligase Turpa_0678 ENOG4105KVH Transcriptional regulator Turpa_0683 ENOG4105F95 Monooxygenase Turpa_0685 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Turpa_0690 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Turpa_0698 ENOG4105BZU Histidine kinase Turpa_0699 ENOG4105C22 threonyL-tRNA synthetase Turpa_0707 ENOG4105EHZ conserved protein UCP016719 Turpa_0708 ENOG4105CE1 Ferrous iron transport protein b Turpa_0717 ENOG4108IJ9 (ABC) transporter Turpa_0721 ENOG4105DRS transport system, permease Turpa_0725 ENOG4108IUM Glycogen debranching enzyme Turpa_0728 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Turpa_0729 ENOG4108ESZ Glycogen debranching enzyme Turpa_0730 ENOG4105DGW oligopeptidase A Turpa_0731 ENOG4105NAE bifunctional deaminase-reductase domain protein Turpa_0735 ENOG4107S1W 4-alpha-glucanotransferase Turpa_0736 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Turpa_0742 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Turpa_0743 ENOG4108RZE Tetr family transcriptional regulator Turpa_0750 ENOG4105BZU Histidine kinase Turpa_0751 ENOG4105K89 arsenate reductase Turpa_0752 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Turpa_0759 ENOG4105W87 Cbs domain Turpa_0763 ENOG4105EAH synthase Turpa_0766 ENOG4105D06 uba thif-type nad fad binding protein Turpa_0768 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Turpa_0772 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Turpa_0792 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Turpa_0793 ENOG4105CBS Chea signal transduction histidine kinase Turpa_0807 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Turpa_0815 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Turpa_0826 ENOG4105D6J arsenicaL-resistance protein Turpa_0827 ENOG4108UXE Protein tyrosine phosphatase Turpa_0829 ENOG4105BZU Histidine kinase Turpa_0831 ENOG4105VCQ rubredoxin Turpa_0834 ENOG4108IAJ Nad-dependent epimerase dehydratase Turpa_0837 ENOG4105CHH sulfate transporter Turpa_0839 ENOG4105F8J Adenylate Guanylate cyclase Turpa_0847 ENOG41071TK Uncharacterised protein family (UPF0150) Turpa_0860 ENOG41069HH 4-oxalocrotonate tautomerase Turpa_0865 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein Turpa_0866 ENOG4105CHR reductase Turpa_0869 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Turpa_0872 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Turpa_0879 ENOG4105K6V RNA polymerase Turpa_0883 ENOG4108A04 Beta-lactamase Turpa_0889 ENOG4107RWR Sodium hydrogen exchanger Turpa_0893 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Turpa_0901 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Turpa_0909 ENOG4105FZW flagellar biosynthesis regulator FlhF Turpa_0910 ENOG4105D7B Flagellar biosynthesis protein flha Turpa_0911 ENOG4105D00 flagellar biosynthetic protein flhB Turpa_0912 ENOG4107QI1 Mate efflux family protein Turpa_0934 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Turpa_0938 ENOG4105EB3 Histidine kinase Turpa_0943 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Turpa_0944 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) Turpa_0945 ENOG4105CFP Peptidase U32 Turpa_0947 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Turpa_0951 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Turpa_0963 ENOG4105EUB pirin domain protein Turpa_0964 ENOG4105BZU Histidine kinase Turpa_0967 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Turpa_0968 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Turpa_0970 ENOG4105VCH membrane Turpa_0971 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Turpa_0979 ENOG4105DEN Luciferase family Turpa_0981 ENOG4105HDK L-asparaginase Turpa_0983 ENOG4105D1H recombination factor protein RarA Turpa_0984 ENOG4105BZ1 (ABC) transporter Turpa_0990 ENOG4105CTQ phosphohexokinase Turpa_0999 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Turpa_1003 ENOG4105F8J Adenylate Guanylate cyclase Turpa_1020 ENOG4108X0B nad(p)h dehydrogenase (quinone) Turpa_1021 ENOG4105U3E Transcriptional regulator Turpa_1030 ENOG4105EHZ conserved protein UCP016719 Turpa_1034 ENOG4105EE1 crotonyl-CoA reductase Turpa_1036 ENOG4107RJ1 sodium solute Turpa_1042 ENOG4105DC1 bifunctional purine biosynthesis protein purh Turpa_1043 ENOG4105U0R haloacid dehalogenase-like hydrolase Turpa_1053 ENOG4105E0X reductase Turpa_1060 ENOG4105F9F transposase Turpa_1076 ENOG4108UT2 hemolysin iii Turpa_1078 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Turpa_1082 ENOG4108ZX6 Electron transport protein SCO1 SenC Turpa_1084 ENOG4105DSF transport protein Turpa_1101 ENOG4106MP8 UPF0754 membrane protein Turpa_1109 ENOG4105CUJ penicillin amidase Turpa_1110 ENOG4105BZU Histidine kinase Turpa_1111 ENOG4105CGS Alpha-glucosidase Turpa_1116 ENOG4108JQC penicillin-binding protein 1A Turpa_1120 ENOG4105C2N RNA methyltransferase TrmH family group 3 Turpa_1124 ENOG4105C9U ATP-dependent DNA helicase RecQ Turpa_1126 ENOG4105EYW Ion transport protein Turpa_1128 ENOG4108K8S endonuclease I Turpa_1130 ENOG4105CG3 alpha amylase, catalytic region Turpa_1131 ENOG4105CBS Chea signal transduction histidine kinase Turpa_1132 ENOG4108T5G Adenylate Turpa_1138 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Turpa_1143 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Turpa_1144 ENOG4105BZU Histidine kinase Turpa_1145 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Turpa_1148 ENOG4105F9F transposase Turpa_1149 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Turpa_1150 ENOG4105BZU Histidine kinase Turpa_1152 ENOG4105CQ7 ATP-dependent helicase Turpa_1156 ENOG4105ECP epimerase Turpa_1159 ENOG4105C26 Dehydrogenase Turpa_1162 ENOG4107QN2 dihydrolipoyl dehydrogenase Turpa_1167 ENOG4107YTP response regulator receiver protein Turpa_1169 ENOG4108YYC ycei family Turpa_1170 ENOG4108T5G Adenylate Turpa_1171 ENOG4105CBS Chea signal transduction histidine kinase Turpa_1175 ENOG4105C1G acyl-Coa dehydrogenase Turpa_1179 ENOG4105CA0 peroxidase Turpa_1183 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Turpa_1187 ENOG4105BZU Histidine kinase Turpa_1188 ENOG4105BZU Histidine kinase Turpa_1191 ENOG41084GC stage II sporulation protein Turpa_1192 ENOG4105CPF Cell wall formation (By similarity) Turpa_1196 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Turpa_1197 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Turpa_1198 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Turpa_1202 ENOG4105EYW Ion transport protein Turpa_1205 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Turpa_1208 ENOG4105K4T epimerase Turpa_1209 ENOG4105KIR Thiol-disulfide oxidoreductase dcc Turpa_1210 ENOG4105E8V Alpha Beta Hydrolase Fold protein Turpa_1214 ENOG4105E9K Isocitrate dehydrogenase Turpa_1222 ENOG4107QX8 SPFH domain, Band 7 family protein Turpa_1240 ENOG4108594 Permease of the drug metabolite transporter Turpa_1244 ENOG4105CKD glutathione-regulated potassium-efflux system protein Turpa_1245 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Turpa_1248 ENOG4105FDK ABC transporter Turpa_1249 ENOG4105DJT lAO AO transport system ATPase Turpa_1256 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Turpa_1263 ENOG4108RS6 transposase Turpa_1265 ENOG4107SGM protein serine threonine phosphatase Turpa_1267 ENOG4108V1T peptidylprolyl cis-trans isomerase Turpa_1274 ENOG4108JUA Transcriptional regulator Turpa_1280 ENOG4105CXB phosphoribosylaminoimidazole synthetase Turpa_1281 ENOG4108V1T peptidylprolyl cis-trans isomerase Turpa_1285 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Turpa_1286 ENOG4105C7W Xanthine dehydrogenase Turpa_1287 ENOG4107YV9 domain protein Turpa_1293 ENOG4105CGZ zinc metallopeptidase Turpa_1297 ENOG4105EG6 Saccharopine dehydrogenase Turpa_1301 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Turpa_1306 ENOG4105F9F transposase Turpa_1307 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) Turpa_1318 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Turpa_1319 ENOG4105WH1 Two component transcriptional regulator luxr family Turpa_1320 ENOG4105BZU Histidine kinase Turpa_1322 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Turpa_1324 ENOG4107QP3 malate synthase g Turpa_1349 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Turpa_1353 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Turpa_1355 ENOG4105DNZ Alpha Beta Hydrolase Turpa_1356 ENOG4108MVM Transposase Turpa_1357 ENOG4108ZQS transposase Turpa_1359 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Turpa_1360 ENOG41060WC Enoyl-CoA hydratase Turpa_1361 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Turpa_1365 ENOG4105DX0 Hemolysin A Turpa_1366 ENOG4105CTB Polyprenyl synthetase Turpa_1371 ENOG4105CMV Succinyl-CoA synthetase subunit beta Turpa_1378 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Turpa_1384 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Turpa_1389 ENOG4105VV6 START domain-containing protein Turpa_1394 ENOG4105BZE flagellar hook protein, FlgE Turpa_1395 ENOG410822I Flagellar hook capping protein Turpa_1397 ENOG4105C34 Pseudouridine synthase Turpa_1400 ENOG4105CPP Dehydrogenase, E1 component Turpa_1401 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Turpa_1402 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Turpa_1404 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Turpa_1405 ENOG4107V9E glucose-1-phosphate thymidylyltransferase Turpa_1406 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Turpa_1407 ENOG4105KB8 (LipO)protein Turpa_1409 ENOG4105D1F ATP-binding protein Turpa_1410 ENOG4108RWP Major Facilitator Superfamily protein Turpa_1412 ENOG4105C1G acyl-Coa dehydrogenase Turpa_1415 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Turpa_1416 ENOG4108V3W Chemotaxis protein, CheW Turpa_1420 ENOG4108UJD 30S ribosomal protein S9 Turpa_1421 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Turpa_1422 ENOG4105EYW Ion transport protein Turpa_1428 ENOG4105VN1 Heat shock protein Turpa_1434 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Turpa_1435 ENOG4108Z7G MaoC domain protein dehydratase Turpa_1437 ENOG4108UYB regulatoR Turpa_1438 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Turpa_1447 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Turpa_1449 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Turpa_1450 ENOG4105BZU Histidine kinase Turpa_1454 ENOG41061CK Antibiotic biosynthesis monooxygenase Turpa_1455 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Turpa_1459 ENOG4105XMH SpoVT AbrB domain protein Turpa_1460 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A Turpa_1461 ENOG4107XM9 (LipO)protein Turpa_1462 ENOG4108YBP pseudouridine synthase Turpa_1475 ENOG4105EMU Dehydrogenase Turpa_1485 ENOG4105IJJ transcriptional regulator, crp fnr family Turpa_1487 ENOG4107R7I amino acid Turpa_1488 ENOG4105KPY Small multidrug resistance protein Turpa_1496 ENOG4108J1Q Turpa_1500 ENOG4105C0D helicase Turpa_1506 ENOG4108ZQS transposase Turpa_1507 ENOG4108MVM Transposase Turpa_1518 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Turpa_1519 ENOG4108U78 Glutathione S-transferase Turpa_1520 ENOG4105CKD glutathione-regulated potassium-efflux system protein Turpa_1522 ENOG4105EYW Ion transport protein Turpa_1523 ENOG4108VD1 dedA family Turpa_1527 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Turpa_1529 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Turpa_1531 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Turpa_1532 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Turpa_1534 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Turpa_1535 ENOG4105C8V SAICAR synthetase Turpa_1537 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Turpa_1540 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Turpa_1542 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Turpa_1548 ENOG4105CEY Amp-dependent synthetase and ligase Turpa_1550 ENOG4105CY0 Metallo-Beta-Lactamase Turpa_1552 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Turpa_1554 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Turpa_1557 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Turpa_1565 ENOG4105C0B DNA polymerase III (alpha subunit) Turpa_1567 ENOG4105WH1 Two component transcriptional regulator luxr family Turpa_1577 ENOG4105DWF phosphomethylpyrimidine kinase Turpa_1584 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) Turpa_1585 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) Turpa_1586 ENOG4108Z6B deaminase Turpa_1590 ENOG4105CS2 ec 3.2.1.21 Turpa_1597 ENOG4105NPE arsR family transcriptional regulator Turpa_1600 ENOG4105DF2 NADH dehydrogenase subunit j Turpa_1601 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Turpa_1602 ENOG4105D65 subunit l Turpa_1604 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Turpa_1605 ENOG4105C0H protease Turpa_1606 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Turpa_1609 ENOG4107YTP response regulator receiver protein Turpa_1618 ENOG4105CKK Glycosyl transferase, family 2 Turpa_1627 ENOG4105F8V Hydrolase, tatD family Turpa_1628 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Turpa_1631 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Turpa_1634 ENOG4105CYP glycoside hydrolase, family Turpa_1639 ENOG4105DR4 Methyltransferase Turpa_1640 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Turpa_1643 ENOG4105F8J Adenylate Guanylate cyclase Turpa_1645 ENOG4105EXC Acyl-transferase Turpa_1666 ENOG4105EXC Acyl-transferase Turpa_1669 ENOG4108V06 Glutathione peroxidase Turpa_1670 ENOG4105CGU Enoyl-CoA hydratase Turpa_1688 ENOG4105CHR reductase Turpa_1689 ENOG4105BZU Histidine kinase Turpa_1697 ENOG4105C4R Atp-dependent dna helicase Turpa_1698 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Turpa_1699 ENOG4105BZU Histidine kinase Turpa_1701 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Turpa_1707 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Turpa_1713 ENOG4105F9F transposase Turpa_1717 ENOG4108ZQS transposase Turpa_1718 ENOG4108MVM Transposase Turpa_1724 ENOG4105EUB pirin domain protein Turpa_1727 ENOG4105BZU Histidine kinase Turpa_1730 ENOG4105CNG UPF0061 protein Turpa_1739 ENOG4105F1N DNA alkylation repair Turpa_1756 ENOG4105VXP Protein of unknown function DUF86 Turpa_1759 ENOG4105EEF Alkane 1-monooxygenase Turpa_1760 ENOG4105CEY Amp-dependent synthetase and ligase Turpa_1761 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Turpa_1777 ENOG4108Z4K mutator MutT protein Turpa_1779 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Turpa_1783 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) Turpa_1784 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Turpa_1791 ENOG4105GR3 Histidine kinase Turpa_1792 ENOG4105CUJ penicillin amidase Turpa_1796 ENOG4105DFU Cell wall formation (By similarity) Turpa_1797 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Turpa_1798 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Turpa_1801 ENOG4105WN5 stage II sporulation protein Turpa_1803 ENOG4105BZU Histidine kinase Turpa_1805 ENOG4105J7D transcriptional regulator Turpa_1808 ENOG4108JQC penicillin-binding protein 1A Turpa_1809 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Turpa_1812 ENOG4107YDW inorganic pyrophosphatase EC 3.6.1.1 Turpa_1813 ENOG4105C5H ABC transporter Turpa_1815 ENOG4105C5H ABC transporter Turpa_1817 ENOG41090R7 Ferric uptake Turpa_1824 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Turpa_1828 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Turpa_1829 ENOG4105CTP PilT protein domain protein Turpa_1830 ENOG4108VJ1 Transcriptional regulator (CarD family Turpa_1833 ENOG4105D3Q Sugar transferase Turpa_1835 ENOG4105C1J atp-dependent rna helicase Turpa_1836 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Turpa_1838 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Turpa_1840 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Turpa_1841 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Turpa_1842 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Turpa_1843 ENOG4107SBE Glycosyl transferase (Group 1 Turpa_1849 ENOG4105D82 Glutamate dehydrogenase Turpa_1850 ENOG4105DFF Rod shape-determining protein mreb Turpa_1853 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Turpa_1857 ENOG41076UM multiple antibiotic resistance (MarC)-related protein Turpa_1858 ENOG4105D8V Glucose sorbosone dehydrogenase Turpa_1863 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Turpa_1873 ENOG4105EEX Two component transcriptional regulator (Winged helix family Turpa_1880 ENOG4105CGA flagellar basal-body rod protein FlgG Turpa_1883 ENOG4105BZU Histidine kinase Turpa_1885 ENOG4107S01 Repressor protein MetJ Turpa_1890 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Turpa_1897 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Turpa_1901 ENOG4108I7Y domain protein Turpa_1904 ENOG4107TE5 Lipid kinase Turpa_1907 ENOG4108HU6 Metal dependent phosphohydrolase Turpa_1912 ENOG4105K46 50S ribosomal protein l27 Turpa_1913 ENOG4108IG5 Transcriptional regulator Turpa_1918 ENOG4105BZU Histidine kinase Turpa_1921 ENOG4108MVM Transposase Turpa_1922 ENOG4108ZQS transposase Turpa_1923 ENOG4105BZU Histidine kinase Turpa_1924 ENOG4105WH1 Two component transcriptional regulator luxr family Turpa_1927 ENOG4107QJE Chromosome Partitioning Protein Turpa_1929 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Turpa_1932 ENOG41082AN stage II sporulation protein Turpa_1934 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Turpa_1936 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Turpa_1937 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Turpa_1938 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Turpa_1939 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Turpa_1941 ENOG4108UH6 UPF0754 membrane protein Turpa_1943 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Turpa_1945 ENOG4105JVQ RNA Polymerase Turpa_1948 ENOG4107RN6 Monooxygenase Turpa_1949 ENOG4105CHU acetyl-coa acetyltransferase Turpa_1952 ENOG4108W6C Dehydrogenase Turpa_1954 ENOG4105CNI cell division protein FtsW Turpa_1955 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Turpa_1956 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Turpa_1960 ENOG4108IQE Amp-dependent synthetase and ligase Turpa_1971 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Turpa_1972 ENOG4105CPF Cell wall formation (By similarity) Turpa_1975 ENOG4107QHQ amino acid Turpa_1977 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Turpa_1979 ENOG4105CKU formyltetrahydrofolate synthetase Turpa_1982 ENOG4107R4J Chloride channel Turpa_1987 ENOG4105DV0 amidase (EC 3.5.1.4 Turpa_1989 ENOG4105DTD Dehydrogenase Turpa_1995 ENOG4108VPT UPF0234 protein Turpa_1996 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Turpa_1998 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Turpa_1999 ENOG4105C1V Peptidase, M16 Turpa_2001 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Turpa_2006 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Turpa_2008 ENOG4105HHA aminodeoxychorismate lyase Turpa_2009 ENOG4107SC1 transglycosylase Turpa_2013 ENOG4108ESY Metal dependent phosphohydrolase Turpa_2021 ENOG4108YYQ gCN5-related N-acetyltransferase Turpa_2027 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Turpa_2032 ENOG4105F9F transposase Turpa_2034 ENOG4107R3A FAD linked oxidase domain protein Turpa_2035 ENOG4105BZU Histidine kinase Turpa_2036 ENOG4105DKP glycosyl transferase, family 9 Turpa_2037 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Turpa_2039 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Turpa_2043 ENOG4105CDY transcriptional regulatory protein Turpa_2046 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Turpa_2049 ENOG4105F8J Adenylate Guanylate cyclase Turpa_2050 ENOG4105E7A Glutamine amidotransferase Turpa_2051 ENOG4105F8J Adenylate Guanylate cyclase Turpa_2052 ENOG4105NWN ApaG protein Turpa_2055 ENOG4105CJN penicillin-binding protein Turpa_2056 ENOG4105CNI cell division protein FtsW Turpa_2062 ENOG4105UQX Mate efflux family protein Turpa_2064 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Turpa_2065 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Turpa_2068 ENOG4105XJC Two component transcriptional regulator (Winged helix family Turpa_2069 ENOG4105C5H ABC transporter Turpa_2071 ENOG4105CTJ Metal Dependent Phosphohydrolase Turpa_2073 ENOG4108HU6 Metal dependent phosphohydrolase Turpa_2076 ENOG4105D5P Methylmalonyl-coA mutase Turpa_2077 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Turpa_2086 ENOG4105EYW Ion transport protein Turpa_2087 ENOG4105XJC Two component transcriptional regulator (Winged helix family Turpa_2091 ENOG4108VWS Yaeq family Turpa_2102 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) Turpa_2109 ENOG4107RQ2 Cytochrome c oxidase, subunit I Turpa_2113 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Turpa_2115 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Turpa_2116 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Turpa_2118 ENOG4105K5M 30s ribosomal protein S16 Turpa_2123 ENOG4105D74 hydrolase Turpa_2125 ENOG4105CA0 peroxidase Turpa_2126 ENOG4105C3R Methionine synthase Turpa_2128 ENOG4105Y3E Modulates RecA activity (By similarity) Turpa_2136 ENOG4107PBH Toxic component of a toxin-antitoxin (TA) module. A Turpa_2138 ENOG4105DJG MaoC domain protein dehydratase Turpa_2144 ENOG4106YT9 Enoyl-CoA hydratase Turpa_2149 ENOG4105C8P )-transporter Turpa_2152 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Turpa_2154 ENOG4105E02 MotA TolQ exbB proton channel Turpa_2155 ENOG4105SG9 biopolymer transport protein, ExbD Turpa_2161 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Turpa_2166 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Turpa_2169 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Turpa_2172 ENOG41060IM Heme exporter protein Turpa_2173 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Turpa_2174 ENOG4105CRK lysyL-tRNA synthetase Turpa_2179 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Turpa_2180 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Turpa_2183 ENOG4105CMG Carbohydrate kinase Turpa_2184 ENOG4105CVK Glutamate decarboxylase Turpa_2195 ENOG4105CUJ penicillin amidase Turpa_2197 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Turpa_2198 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Turpa_2201 ENOG4107104 thymidine kinase Turpa_2202 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Turpa_2204 ENOG4105KNE Phosphatidate cytidylyltransferase Turpa_2208 ENOG4105F5W AtP-binding protein Turpa_2209 ENOG4105C1G acyl-Coa dehydrogenase Turpa_2210 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Turpa_2211 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Turpa_2212 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Turpa_2230 ENOG4105CP7 Triose-phosphate isomerase Turpa_2231 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Turpa_2241 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Turpa_2244 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Turpa_2247 ENOG4105DSJ YicC domain protein Turpa_2248 ENOG4105KC4 UPF0296 protein Turpa_2250 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Turpa_2252 ENOG4107XMU Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Turpa_2256 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Turpa_2260 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Turpa_2261 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Turpa_2263 ENOG4107RN3 metallophosphoesterase Turpa_2264 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Turpa_2265 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Turpa_2266 ENOG41082AN stage II sporulation protein Turpa_2269 ENOG4108IUZ ABC transporter Turpa_2270 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Turpa_2271 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Turpa_2272 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Turpa_2276 ENOG4105CHR reductase Turpa_2278 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Turpa_2279 ENOG4105CHP RNA polymerase Turpa_2280 ENOG4105GRZ Ycii-related protein Turpa_2283 ENOG4105E4C Lytic transglycosylase catalytic Turpa_2284 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Turpa_2293 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Turpa_2296 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Turpa_2308 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein Turpa_2309 ENOG4105BZU Histidine kinase Turpa_2310 ENOG4105C3J Cysteine desulfurase Turpa_2315 ENOG4107YU2 histidine triad (hIT) protein Turpa_2321 ENOG4105SYT Methylenetetrahydrofolate reductase Turpa_2323 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Turpa_2328 ENOG4105KZX Pterin carbinolamine dehydratase Turpa_2330 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Turpa_2331 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Turpa_2332 ENOG4105DEF Extracellular solute-binding protein, family 5 Turpa_2336 ENOG4105E0M Sulfatase Turpa_2339 ENOG4105DTI Phosphonopyruvate decarboxylase Turpa_2343 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase Turpa_2346 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Turpa_2347 ENOG4105DQU oxidoreductase, subunit beta Turpa_2349 ENOG4105EKE dihydroorotase Turpa_2350 ENOG4105C2N RNA methyltransferase TrmH family group 3 Turpa_2353 ENOG41084GC stage II sporulation protein Turpa_2363 ENOG4105I03 Flagellin Turpa_2364 ENOG4105I03 Flagellin Turpa_2395 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Turpa_2397 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Turpa_2398 ENOG4105CDU Replicative dna helicase Turpa_2400 ENOG4105DR5 peptidase Turpa_2401 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Turpa_2405 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate Turpa_2408 ENOG4107YTP response regulator receiver protein Turpa_2411 ENOG41090BQ Glutaredoxin Turpa_2421 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Turpa_2424 ENOG4105CKB glycosidase Turpa_2428 ENOG4105C0A alcohol dehydrogenase Turpa_2434 ENOG4105C5E polysaccharide biosynthesis protein Turpa_2437 ENOG4105BZU Histidine kinase Turpa_2439 ENOG4105EWK phytoene Turpa_2440 ENOG4107QN2 dihydrolipoyl dehydrogenase Turpa_2447 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) Turpa_2448 ENOG410842R atp synthase Turpa_2453 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Turpa_2454 ENOG41082MC Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Turpa_2455 ENOG4105EJ2 Transcriptional regulator Turpa_2456 ENOG4105DQR SNARE associated Golgi Turpa_2459 ENOG4105S2T inner membrane protein YbcI Turpa_2462 ENOG4108ZB6 transcriptional regulator AsnC family Turpa_2465 ENOG4108Z6B deaminase Turpa_2466 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Turpa_2469 ENOG4108A04 Beta-lactamase Turpa_2474 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Turpa_2477 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Turpa_2480 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Turpa_2483 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Turpa_2487 ENOG4108ZAF Molybdopterin Turpa_2489 ENOG4105D06 uba thif-type nad fad binding protein Turpa_2494 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Turpa_2504 ENOG41090HT Inherit from COG: transposase Turpa_2507 ENOG4105C1G acyl-Coa dehydrogenase Turpa_2510 ENOG4107QN2 dihydrolipoyl dehydrogenase Turpa_2512 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Turpa_2514 ENOG4105DGU Histone deacetylase Turpa_2516 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Turpa_2517 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Turpa_2520 ENOG4107QXV Phosphate transporter Turpa_2522 ENOG4105C1J atp-dependent rna helicase Turpa_2525 ENOG4105CHU acetyl-coa acetyltransferase Turpa_2526 ENOG4105C10 Electron transfer flavoprotein Turpa_2527 ENOG4105BZJ Electron transfer flavoprotein Turpa_2528 ENOG41082BM Transcriptional regulator, arsr family Turpa_2529 ENOG4105F9F transposase Turpa_2533 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Turpa_2540 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Turpa_2543 ENOG4105CGA flagellar basal-body rod protein FlgG Turpa_2545 ENOG4107RN6 Monooxygenase Turpa_2547 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Turpa_2549 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Turpa_2550 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Turpa_2551 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Turpa_2553 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Turpa_2555 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Turpa_2556 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Turpa_2557 ENOG41082SA 50s ribosomal protein l29 Turpa_2558 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Turpa_2560 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Turpa_2561 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Turpa_2562 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Turpa_2563 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Turpa_2565 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Turpa_2566 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Turpa_2567 ENOG4105VPB 50S ribosomal protein L30 Turpa_2568 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Turpa_2569 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Turpa_2572 ENOG41067V7 50S ribosomal protein L36 Turpa_2573 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Turpa_2574 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Turpa_2575 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Turpa_2577 ENOG4108ZT0 50S ribosomal protein l17 Turpa_2579 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Turpa_2580 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Turpa_2582 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Turpa_2588 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Turpa_2589 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Turpa_2594 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Turpa_2595 ENOG4105M7K Involved in the transcription termination process (By similarity) Turpa_2597 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Turpa_2600 ENOG4105EVH UPF0753 protein Turpa_2601 ENOG4105D65 subunit l Turpa_2607 ENOG4105C28 cystathionine Turpa_2608 ENOG4108UKZ OsmC family Turpa_2610 ENOG4105CBT Fructose-1,6-bisphosphatase Turpa_2613 ENOG4105GAV receptor Turpa_2618 ENOG4105E27 serine threonine protein kinase Turpa_2620 ENOG4107FW0 short-chain dehydrogenase reductase Turpa_2621 ENOG41082QS Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Turpa_2622 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Turpa_2623 ENOG4105CHV Transcription elongation factor NusA Turpa_2627 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Turpa_2628 ENOG4105DXI Major Facilitator superfamily Turpa_2631 ENOG4105F2W methyltransferase Turpa_2634 ENOG4105KAC Antibiotic biosynthesis monooxygenase Turpa_2636 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Turpa_2640 ENOG4105CJR Integral membrane protein (MviN Turpa_2641 ENOG4105DDQ anthranilate synthase Turpa_2642 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Turpa_2647 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Turpa_2648 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Turpa_2650 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Turpa_2651 ENOG41086CX Inherit from COG: 40-residue yvtn family beta-propeller repeat protein Turpa_2654 ENOG4105DD5 Flagellar motor switch protein Turpa_2657 ENOG4105C2M dna polymerase I Turpa_2658 ENOG4108MVM Transposase Turpa_2659 ENOG4108ZQS transposase Turpa_2670 ENOG4105CVR type I restriction-modification system Turpa_2671 ENOG4105EKX Restriction modification system DNA (Specificity Turpa_2675 ENOG4108J1Q Turpa_2677 ENOG4105DZR Type I site-specific deoxyribonuclease Turpa_2681 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Turpa_2686 ENOG4105CEN a g-specific adenine glycosylase Turpa_2687 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Turpa_2688 ENOG4105DHJ ABC, transporter Turpa_2693 ENOG4105EMU Dehydrogenase Turpa_2698 ENOG4105DBI uridine monophosphokinase Turpa_2700 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Turpa_2704 ENOG4105E4C Lytic transglycosylase catalytic Turpa_2706 ENOG4107QKZ Ompa motb domain protein Turpa_2708 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Turpa_2709 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Turpa_2710 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Turpa_2711 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Turpa_2714 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Turpa_2719 ENOG4105DFH Transport of potassium into the cell (By similarity) Turpa_2720 ENOG4105DFH Transport of potassium into the cell (By similarity) Turpa_2721 ENOG4107QX3 carboxylase Turpa_2722 ENOG4108UKI Enoyl-CoA hydratase Turpa_2729 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Turpa_2740 ENOG4105CBC glutamate synthase Turpa_2741 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Turpa_2742 ENOG4105D52 delta-aminolevulinic acid dehydratase Turpa_2743 ENOG4105DR5 peptidase Turpa_2744 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Turpa_2746 ENOG4107QIZ NADH dehydrogenase Turpa_2747 ENOG4107QHI -hydrogenase Turpa_2751 ENOG4105QNF Outer membrane lipoprotein Turpa_2753 ENOG4108T5G Adenylate Turpa_2754 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Turpa_2755 ENOG4105CHR reductase Turpa_2757 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase Turpa_2761 ENOG4105C1G acyl-Coa dehydrogenase Turpa_2767 ENOG4105CHU acetyl-coa acetyltransferase Turpa_2770 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Turpa_2772 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Turpa_2773 ENOG4105E0X reductase Turpa_2774 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Turpa_2779 ENOG4105PDP Short chain dehydrogenase Turpa_2781 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Turpa_2782 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Turpa_2784 ENOG4105IPI Membrane Turpa_2786 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Turpa_2790 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit Turpa_2796 ENOG4105DR5 peptidase Turpa_2798 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Turpa_2807 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Turpa_2809 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Turpa_2811 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Turpa_2812 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Turpa_2820 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Turpa_2821 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Turpa_2822 ENOG4105EUB pirin domain protein Turpa_2824 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Turpa_2825 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Turpa_2827 ENOG4108UJU UPF0301 protein Turpa_2833 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Turpa_2841 ENOG4105CHR reductase Turpa_2843 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Turpa_2845 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Turpa_2851 ENOG4107QRG dna polymerase iii Turpa_2852 ENOG4105CM2 brancheD-chain amino acid aminotransferase Turpa_2853 ENOG4105C3M thioredoxin reductase Turpa_2857 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Turpa_2862 ENOG4105DMF Dehydrogenase Turpa_2863 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) Turpa_2864 ENOG4105EYW Ion transport protein Turpa_2866 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Turpa_2867 ENOG4105NBK UPF0345 protein Turpa_2869 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Turpa_2874 ENOG4105CY0 Metallo-Beta-Lactamase Turpa_2875 ENOG4105DVT helicase Turpa_2876 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Turpa_2877 ENOG4105C3U ABC transporter Turpa_2879 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Turpa_2882 ENOG4108VZM 50s ribosomal protein L10 Turpa_2883 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Turpa_2887 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Turpa_2888 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Turpa_2891 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Turpa_2894 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Turpa_2897 ENOG4105BZU Histidine kinase Turpa_2899 ENOG4105C12 Phosphoribosylglycinamide synthetase Turpa_2901 ENOG4105F8J Adenylate Guanylate cyclase Turpa_2905 ENOG4105K8N protein family UPF0079, ATPase Turpa_2907 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Turpa_2912 ENOG4105E63 Pfam:DUF178 Turpa_2914 ENOG4105DJV ribulose-phosphate 3-epimerase Turpa_2918 ENOG4108JQC penicillin-binding protein 1A Turpa_2919 ENOG4105C6E dna polymerase iii Turpa_2922 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Turpa_2923 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Turpa_2925 ENOG4108YBP pseudouridine synthase Turpa_2926 ENOG4108JEZ rRNA small subunit methyltransferase G Turpa_2928 ENOG4105C26 Dehydrogenase Turpa_2930 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) Turpa_2933 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Turpa_2934 ENOG4105E39 Enoyl-CoA hydratase Turpa_2935 ENOG4106H78 methyltransferase Turpa_2938 ENOG4105E2X shikimate dehydrogenase Turpa_2944 ENOG41077A9 carbonic anhydrase Turpa_2947 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Turpa_2948 ENOG4108Z5K methylglyoxal synthase Turpa_2950 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) Turpa_2958 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Turpa_2959 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Turpa_2960 ENOG4105F9F transposase Turpa_2962 ENOG4105IU3 Glutathione S-transferase Turpa_2964 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Turpa_2969 ENOG41080B9 Binds together with S18 to 16S ribosomal RNA (By similarity) Turpa_2970 ENOG4108UUM single-stranded DNA-binding protein Turpa_2973 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Turpa_2974 ENOG4105C25 Primosomal protein n' Turpa_2978 ENOG4105CN1 protease Turpa_2979 ENOG41082AN stage II sporulation protein Turpa_2981 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Turpa_2984 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Turpa_2985 ENOG4105PNM synthesis protein Turpa_2990 ENOG4105C09 Bile acid Turpa_2991 ENOG4105C72 UPF0176 protein Turpa_2994 ENOG4108Z0R Transferase Turpa_2996 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Turpa_3004 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) Turpa_3005 ENOG4105CGY Dna recombination protein Turpa_3006 ENOG4105BZU Histidine kinase Turpa_3008 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Turpa_3009 ENOG4105E33 succinate dehydrogenase Turpa_3010 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) Turpa_3011 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Turpa_3016 ENOG4108JA2 transcriptioN-repair coupling factor Turpa_3017 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Turpa_3020 ENOG4107UP5 Phosphatidylserine decarboxylase Turpa_3024 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Turpa_3031 ENOG4105I03 Flagellin Turpa_3047 ENOG4105K4H Nlp p60 protein Turpa_3050 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Turpa_3051 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Turpa_3057 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Turpa_3059 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Turpa_3064 ENOG4105JEU Glycosyl transferase, family 2 Turpa_3068 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Turpa_3071 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Turpa_3074 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Turpa_3077 ENOG4105FGM Fructosamine kinase Turpa_3078 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Turpa_3079 ENOG4105C89 phosphohexose isomerase Turpa_3080 ENOG4105EV9 Alpha Beta Hydrolase Turpa_3081 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Turpa_3082 ENOG4105EAC phosphoserine phosphatase Turpa_3086 ENOG4105DWT malate dehydrogenase (quinone) Turpa_3088 ENOG4105C8J )-transporter Turpa_3094 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Turpa_3095 ENOG4105C0P Mg chelatase subunit ChlI Turpa_3096 ENOG4105C7F AcnD-accessory protein PrpF Turpa_3097 ENOG4105F9F transposase Turpa_3103 ENOG4108I0Z Aconitate hydratase Turpa_3106 ENOG4105C01 Dihydroxy-acid dehydratase Turpa_3108 ENOG4108WBT adenosyltransferase Turpa_3117 ENOG41080V3 Major Facilitator superfamily Turpa_3119 ENOG4105CH7 arginosuccinase Turpa_3121 ENOG4105C2X Arabinose 5-phosphate isomerase Turpa_3124 ENOG4105K64 Glycosyl transferase, family 2 Turpa_3126 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Turpa_3127 ENOG4107RGD Major Facilitator superfamily Turpa_3129 ENOG4105C4K Nad synthetase Turpa_3132 ENOG4105W3H MtN3 and saliva related transmembrane protein Turpa_3135 ENOG4105D17 glycoside hydrolase, family 3 domain protein Turpa_3138 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Turpa_3139 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Turpa_3140 ENOG4105DUM transcriptional regulator, lysR family Turpa_3141 ENOG4105SCY DNAK suppressor Turpa_3144 ENOG4105VFU Rna-binding protein Turpa_3149 ENOG4105SG9 biopolymer transport protein, ExbD Turpa_3150 ENOG4105E02 MotA TolQ exbB proton channel Turpa_3153 ENOG4105W0E 50S ribosomal protein L33 Turpa_3162 ENOG4105CHM Aminotransferase Turpa_3163 ENOG4105BZA Phosphoglycerate kinase Turpa_3171 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Turpa_3172 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Turpa_3174 ENOG4107S85 alpha-2-macroglobulin domain protein Turpa_3181 ENOG4108M8H domain protein Turpa_3183 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Turpa_3184 ENOG4108UGV hypoxanthine phosphoribosyltransferase Turpa_3192 ENOG4105C3F Signal peptidase i Turpa_3195 ENOG4105DFU Cell wall formation (By similarity) Turpa_3196 ENOG4108T5G Adenylate Turpa_3197 ENOG4105C79 DNA protecting protein DprA Turpa_3200 ENOG4108R6K riboflavin synthase, subunit alpha Turpa_3205 ENOG4107SFQ iron-sulfur binding Turpa_3210 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase Turpa_3213 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Turpa_3214 ENOG4108UQY Iron-storage protein Turpa_3221 ENOG41088T4 Helicase IV Turpa_3222 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) Turpa_3224 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) Turpa_3234 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Turpa_3239 ENOG4105C8B TIGR00159 family Turpa_3241 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Turpa_3242 ENOG4107RRM 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Turpa_3244 ENOG4105E09 nadh pyrophosphatase Turpa_3245 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Turpa_3247 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Turpa_3251 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Turpa_3254 ENOG4108K8S endonuclease I Turpa_3260 ENOG4105FYV Amp nucleosidase Turpa_3261 ENOG4105BZU Histidine kinase Turpa_3263 ENOG4108JU5 Magnesium and cobalt efflux protein Turpa_3267 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Turpa_3270 ENOG4105CY3 ABC transporter, permease Turpa_3271 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Turpa_3279 ENOG4107XM9 (LipO)protein Turpa_3281 ENOG4105C7K acetolactate synthase Turpa_3284 ENOG4105F9F transposase Turpa_3287 ENOG4108V3E phosphoribosylglycinamide formyltransferase Turpa_3291 ENOG4108JYK Dehydrogenase Turpa_3292 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Turpa_3297 ENOG4105C1G acyl-Coa dehydrogenase Turpa_3299 ENOG4108IG5 Transcriptional regulator Turpa_3307 ENOG4108R4U Hnh endonuclease Turpa_3312 ENOG4105I03 Flagellin Turpa_3329 ENOG41080ET plasmid maintenance system killer protein Turpa_3330 ENOG4105VDM plasmid maintenance system antidote protein, xre family Turpa_3345 ENOG4108MVM Transposase Turpa_3346 ENOG4108ZQS transposase Turpa_3355 ENOG4106H3A restriction Turpa_3372 ENOG4105D06 uba thif-type nad fad binding protein Turpa_3374 ENOG41089UC methyltransferase, type 11 Turpa_3399 ENOG4108ZQS transposase Turpa_3405 ENOG4108MVM Transposase Turpa_3406 ENOG4108ZQS transposase Turpa_3413 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation Turpa_3435 ENOG4108MVM Transposase Turpa_3436 ENOG4108ZQS transposase Turpa_3440 ENOG4105CUC YeeE YedE family protein Turpa_3441 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Turpa_3442 ENOG4105WZW rhodanese family Turpa_3447 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Turpa_3471 ENOG4108J1Q Turpa_3472 ENOG4107RRE RNA-directed DNA polymerase Turpa_3500 ENOG4108MVM Transposase Turpa_3501 ENOG4108ZQS transposase Turpa_3522 ENOG4105VTW prevent-host-death family Turpa_3523 ENOG4105KRQ Addiction module toxin, Txe YoeB family Turpa_3526 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system Turpa_3528 ENOG4108MVM Transposase Turpa_3529 ENOG4108ZQS transposase Turpa_3534 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) Turpa_3535 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit Turpa_3536 ENOG4108WBK V-type ATP synthase subunit D Turpa_3540 ENOG4108T5G Adenylate Turpa_3566 ENOG4105C0D helicase Turpa_3571 ENOG4108J1Q Turpa_3579 ENOG4105D1H recombination factor protein RarA Turpa_3603 ENOG4105C0D helicase Turpa_3611 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Turpa_3622 ENOG4107KIA Virulence factor Mce family protein Turpa_3626 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Turpa_3633 ENOG4105DJ0 Poly(A) Polymerase Turpa_3636 ENOG4108QBX (LipO)protein Turpa_3637 ENOG4105BZU Histidine kinase Turpa_3641 ENOG4105DR5 peptidase Turpa_3642 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Turpa_3646 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Turpa_3649 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Turpa_3651 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Turpa_3652 ENOG4105VS8 Flagellar biosynthetic protein fliq Turpa_3653 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Turpa_3655 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Turpa_3657 ENOG4105SFS phosphoesterase RecJ domain protein Turpa_3660 ENOG4105MQ3 flagellar protein FliS Turpa_3662 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Turpa_3663 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Turpa_3665 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Turpa_3669 ENOG4105DG6 mannose-6-phosphate isomerase Turpa_3672 ENOG4105CJ1 ABC, transporter Turpa_3681 ENOG4108VAU general secretion pathway protein G Turpa_3683 ENOG4105F8J Adenylate Guanylate cyclase Turpa_3684 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Turpa_3692 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) Turpa_3696 ENOG4105C3J Cysteine desulfurase Turpa_3698 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Turpa_3699 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Turpa_3700 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Turpa_3702 ENOG4108IQE Amp-dependent synthetase and ligase Turpa_3704 ENOG4108M8H domain protein Turpa_3705 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Turpa_3707 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Turpa_3708 ENOG4108W9H Tetr family transcriptional regulator Turpa_3715 ENOG4105C5H ABC transporter Turpa_3723 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Turpa_3727 ENOG4107TY6 Acylneuraminate cytidylyltransferase Turpa_3728 ENOG4108T5G Adenylate Turpa_3730 ENOG4108IJ6 ABC transporter Turpa_3731 ENOG4105ECW sulfate abc transporter Turpa_3732 ENOG4108I5D sulfate abc transporter Turpa_3733 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Turpa_3734 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Turpa_3736 ENOG4108JCI Transcriptional regulator Turpa_3742 ENOG4108Z86 Glutamine amidotransferase Turpa_3743 ENOG4108ME1 Peptidase M55 D-aminopeptidase Turpa_3747 ENOG4105C5F glutamine synthetase Turpa_3751 ENOG4105KAF membrAne Turpa_3753 ENOG4108IYU L-aspartate oxidase Turpa_3754 ENOG4105EQI Metal Dependent Phosphohydrolase Turpa_3756 ENOG4105E39 Enoyl-CoA hydratase Turpa_3758 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Turpa_3760 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Turpa_3767 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Turpa_3768 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Turpa_3769 ENOG4105CKK Glycosyl transferase, family 2 Turpa_3771 ENOG4105DR5 peptidase Turpa_3782 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Turpa_3783 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Turpa_3785 ENOG4105DFA alanine racemase domain protein Turpa_3787 ENOG4105VIE preprotein translocase, subunit YajC Turpa_3789 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Turpa_3790 ENOG4108JIS Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Turpa_3791 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Turpa_3792 ENOG4105W8H transhydrogenase (subunit alpha Turpa_3793 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Turpa_3794 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Turpa_3795 ENOG4108UUM single-stranded DNA-binding protein Turpa_3799 ENOG4105D7Z glutathione synthase Turpa_3800 ENOG4105DA5 (ABC) transporter Turpa_3801 ENOG4105E3A (ABC) transporter Turpa_3802 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Turpa_3804 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Turpa_3806 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) Turpa_3807 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Turpa_3808 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Turpa_3809 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Turpa_3815 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Turpa_3820 ENOG4105CDV Ompa motb domain protein Turpa_3827 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid Turpa_3831 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase Turpa_3833 ENOG4107VNU Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Turpa_3838 ENOG4105C31 Tryptophanyl-tRNA synthetase Turpa_3839 ENOG4107QII Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Turpa_3840 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Turpa_3841 ENOG4105CQC Prephenate dehydratase Turpa_3843 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Turpa_3845 ENOG4105CJQ hydrolase, family 31 Turpa_3850 ENOG4108T5G Adenylate Turpa_3852 ENOG4108VYJ response regulator receiver protein Turpa_3854 ENOG4108VYJ response regulator receiver protein Turpa_3855 ENOG4108VYJ response regulator receiver protein Turpa_3856 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Turpa_3857 ENOG4105BZU Histidine kinase Turpa_3858 ENOG4105BZU Histidine kinase Turpa_3859 ENOG4105BZU Histidine kinase Turpa_3860 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Turpa_3861 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Turpa_3862 ENOG4108V3W Chemotaxis protein, CheW Turpa_3863 ENOG4105CBS Chea signal transduction histidine kinase Turpa_3865 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Turpa_3866 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Turpa_3867 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Turpa_3868 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Turpa_3884 ENOG4105C8Y Acetylornithine aminotransferase Turpa_3885 ENOG4105D49 3-dehydroquinate synthase Turpa_3886 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Turpa_3888 ENOG4107X2U Inherit from COG: Exonuclease-like protein Turpa_3890 ENOG4105C0D helicase Turpa_3892 ENOG4105CHR reductase Turpa_3897 ENOG4108JQC penicillin-binding protein 1A Turpa_3901 ENOG4108YZA Nitrogen regulatory protein pii Turpa_3902 ENOG4105BZU Histidine kinase Turpa_3903 ENOG4108YZA Nitrogen regulatory protein pii Turpa_3906 ENOG4105DTN riboflavin biosynthesis protein ribF Turpa_3908 ENOG4105K63 Thioredoxin Turpa_3909 ENOG4105DR5 peptidase Turpa_3915 ENOG4107QZ7 Cellulose synthase catalytic subunit Turpa_3922 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Turpa_3925 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Turpa_3926 ENOG4105F9F transposase Turpa_3929 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Turpa_3933 ENOG4105C1G acyl-Coa dehydrogenase Turpa_3941 ENOG4105BZU Histidine kinase Turpa_3944 ENOG4107RAQ aminopeptidase Turpa_3945 ENOG4105CKK Glycosyl transferase, family 2 Turpa_3950 ENOG4105BZ1 (ABC) transporter Turpa_3951 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Turpa_3953 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Turpa_3955 ENOG4105KJF protein tyrosine phosphatase Turpa_3962 ENOG4105CEV competence damage-inducible protein Turpa_3963 ENOG4105ED9 Protein of unknown function (DUF455) Turpa_3965 ENOG4105E6M Sulphatase-modifying factor protein Turpa_3969 ENOG41085YX 50S ribosomal protein L32 Turpa_3970 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Turpa_3973 ENOG4105DA5 (ABC) transporter Turpa_3975 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Turpa_3980 ENOG4105C1G acyl-Coa dehydrogenase Turpa_3986 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Turpa_3988 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Turpa_3989 ENOG4105C5F glutamine synthetase Turpa_3990 ENOG4105EMU Dehydrogenase Turpa_3992 ENOG4105D7N magnesium and cobalt transport protein CorA Turpa_3993 ENOG4105CIH Imidazole acetol-phosphate transaminase Turpa_3994 ENOG4105FA0 parb-like partition protein Turpa_3995 ENOG4107QJE Chromosome Partitioning Protein Turpa_3996 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Turpa_4000 ENOG4107QP7 CoA-transferase subunit A Turpa_4005 ENOG4105CCT upf0313 protein Turpa_4007 ENOG4105EE1 crotonyl-CoA reductase Turpa_4008 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Turpa_4009 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Turpa_4010 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Turpa_4013 ENOG4105DBV ornithine carbamoyltransferase Turpa_4015 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Turpa_4016 ENOG4108IQE Amp-dependent synthetase and ligase Turpa_4018 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) Turpa_4019 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Turpa_4021 ENOG4105D4P Coproporphyrinogen iii oxidase Turpa_4027 ENOG4105W2B Flagellar assembly protein Turpa_4028 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Turpa_4029 ENOG4107U2N Flagellar M-ring protein Turpa_4031 ENOG41069WH flagellar hook-basal body complex Turpa_4032 ENOG4108ZC9 flagellar basal-body rod protein flgc Turpa_4033 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Turpa_4041 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Turpa_4044 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Turpa_4045 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Turpa_4048 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Turpa_4049 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Turpa_4050 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Turpa_4054 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) Turpa_4056 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Turpa_4059 ENOG4105K4W Could be involved in septation (By similarity) Turpa_4064 ENOG4105MXB limonene-12-epoxide hydrolase Turpa_4065 ENOG4105CR4 methylisocitrate lyase Turpa_4067 ENOG41082BM Transcriptional regulator, arsr family Turpa_4068 ENOG4105CVA phosphate Turpa_4069 ENOG4105C8U phosphate abc transporter Turpa_4070 ENOG4105E2Z phosphate ABC transporter (Permease Turpa_4071 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Turpa_4072 ENOG4108UTW Plays a role in the regulation of phosphate uptake Turpa_4075 ENOG4105BZF Glycosyl transferase (Group 1 Turpa_4079 ENOG4105H63 Glycosyl transferase, family 2 Turpa_4091 ENOG4108RS6 transposase Turpa_4097 ENOG4107QRT dEAD DEAH box helicase Turpa_4100 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Turpa_4101 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Turpa_4110 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Turpa_4113 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Turpa_4115 ENOG4105CHM Aminotransferase Turpa_4119 ENOG4105CJN penicillin-binding protein Turpa_4121 ENOG4105GVR general secretion pathway protein D Turpa_4122 ENOG4107QHF type ii secretion system protein e Turpa_4124 ENOG4105M5K heptosyltransferase Turpa_4125 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Turpa_4126 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Turpa_4127 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Turpa_4129 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Turpa_4130 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Turpa_4132 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Turpa_4133 ENOG4105DC1 bifunctional purine biosynthesis protein purh Turpa_4134 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Turpa_4137 ENOG4108YZY peptidylprolyl cis-trans isomerase Turpa_4139 ENOG4107TS3 membrane protein, TerC Turpa_4141 ENOG4105C3G gtp-binding protein Turpa_4151 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Turpa_4152 ENOG4105E39 Enoyl-CoA hydratase Turpa_4154 ENOG4105C4K Nad synthetase Turpa_4157 ENOG4105BZN citrate synthase Turpa_4158 ENOG41080R2 UPF0102 protein Turpa_4162 ENOG4105JRK feS assembly protein SufD Turpa_4163 ENOG4105VG1 fes assembly suf system protein Turpa_4168 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Turpa_R0043 ENOG4105F9F transposase