locus-tag	class	description
UV8b_00044	COG0402	S-adenosylhomocysteine deaminase activity
UV8b_00046	COG5383	Protein conserved in bacteria
UV8b_00120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UV8b_00157	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UV8b_00197	COG0508	dehydrogenase complex catalyzes the overall conversion of
UV8b_00215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UV8b_00307	COG0724	RNA recognition motif
UV8b_00339	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
UV8b_00414	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UV8b_00414	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UV8b_00434	COG0316	Belongs to the HesB IscA family
UV8b_00448	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UV8b_00488	COG2217	Heavy metal translocating P-type atpase
UV8b_00489	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UV8b_00498	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UV8b_00581	COG0625	glutathione transferase activity
UV8b_00585	COG2814	Major facilitator Superfamily
UV8b_00600	COG0477	Major facilitator Superfamily
UV8b_00618	COG0288	reversible hydration of carbon dioxide
UV8b_00700	COG0183	Belongs to the thiolase family
UV8b_00725	COG0101	tRNA pseudouridine synthase activity
UV8b_00748	COG0443	Heat shock 70 kDa protein
UV8b_00804	COG2124	cytochrome p450
UV8b_00804	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UV8b_00830	COG0193	aminoacyl-tRNA hydrolase activity
UV8b_00863	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UV8b_00913	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UV8b_00928	COG0017	Asparaginyl-tRNA synthetase
UV8b_00991	COG1643	Atp-dependent helicase
UV8b_01001	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UV8b_01001	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UV8b_01051	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UV8b_01051	COG1024	Enoyl-CoA hydratase
UV8b_01080	COG0489	protein tyrosine kinase activity
UV8b_01107	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UV8b_01165	COG0563	adenylate kinase activity
UV8b_01209	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UV8b_01209	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UV8b_01210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UV8b_01232	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UV8b_01325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UV8b_01339	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UV8b_01465	COG1063	alcohol dehydrogenase
UV8b_01468	COG0604	alcohol dehydrogenase
UV8b_01482	COG2226	methyltransferase
UV8b_01573	COG2072	flavoprotein involved in K transport
UV8b_01587	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UV8b_01615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UV8b_01615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UV8b_01626	COG3118	belongs to the thioredoxin family
UV8b_01641	COG0415	Belongs to the DNA photolyase family
UV8b_01646	COG0515	serine threonine protein kinase
UV8b_01646	COG2815	serine threonine protein kinase
UV8b_01663	COG1335	isochorismatase
UV8b_01730	COG2814	Major facilitator Superfamily
UV8b_01820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UV8b_01872	COG0154	amidase activity
UV8b_01918	COG0009	L-threonylcarbamoyladenylate synthase
UV8b_01954	COG0515	serine threonine protein kinase
UV8b_01984	COG0154	amidase activity
UV8b_02043	COG0515	serine threonine protein kinase
UV8b_02071	COG0673	inositol 2-dehydrogenase activity
UV8b_02100	COG0823	Involved in the tonB-independent uptake of proteins
UV8b_02118	COG0167	dihydroorotate dehydrogenase activity
UV8b_02182	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UV8b_02193	COG0513	Belongs to the DEAD box helicase family
UV8b_02229	COG1741	Belongs to the pirin family
UV8b_02242	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UV8b_02245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UV8b_02287	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UV8b_02299	COG3830	Belongs to the UPF0237 family
UV8b_02299	COG0560	Phosphoserine phosphatase
UV8b_02300	COG0175	sulfate reduction
UV8b_02305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UV8b_02305	COG1648	precorrin-2 dehydrogenase activity
UV8b_02309	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UV8b_02316	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UV8b_02318	COG0833	amino acid
UV8b_02332	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UV8b_02385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
UV8b_02399	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UV8b_02403	COG0626	cystathionine gamma-synthase activity
UV8b_02545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UV8b_02580	COG0756	dUTP diphosphatase activity
UV8b_02617	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
UV8b_02631	COG0542	response to heat
UV8b_02717	COG0285	dihydrofolate synthase activity
UV8b_02820	COG0354	folic acid binding
UV8b_02901	COG0508	dehydrogenase complex catalyzes the overall conversion of
UV8b_02959	COG1643	Atp-dependent helicase
UV8b_03095	COG1643	Atp-dependent helicase
UV8b_03099	COG0829	nickel cation binding
UV8b_03112	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UV8b_03136	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UV8b_03145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UV8b_03182	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UV8b_03242	COG1454	alcohol dehydrogenase
UV8b_03299	COG0109	protoheme IX farnesyltransferase activity
UV8b_03344	COG1132	(ABC) transporter
UV8b_03417	COG0833	amino acid
UV8b_03430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
UV8b_03436	COG3693	PFAM glycoside hydrolase, family 10
UV8b_03473	COG3781	membrane
UV8b_03496	COG1234	tRNA 3'-trailer cleavage
UV8b_03512	COG2020	methyltransferase activity
UV8b_03548	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UV8b_03595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UV8b_03614	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UV8b_03659	COG0513	Belongs to the DEAD box helicase family
UV8b_03682	COG0363	glucosamine-6-phosphate deaminase activity
UV8b_03810	COG0493	'glutamate synthase
UV8b_03834	COG1122	ATPase activity
UV8b_03863	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UV8b_03909	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UV8b_03946	COG0513	Belongs to the DEAD box helicase family
UV8b_03948	COG0484	heat shock protein binding
UV8b_04098	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UV8b_04128	COG0417	DNA replication proofreading
UV8b_04135	COG2815	serine threonine protein kinase
UV8b_04135	COG0515	serine threonine protein kinase
UV8b_04147	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UV8b_04182	COG1196	nuclear chromosome segregation
UV8b_04196	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UV8b_04221	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
UV8b_04238	COG0572	uridine kinase
UV8b_04443	COG0513	Belongs to the DEAD box helicase family
UV8b_04531	COG2351	hydroxyisourate hydrolase activity
UV8b_04557	COG1643	Atp-dependent helicase
UV8b_04561	COG0123	including yeast histone deacetylase and acetoin utilization protein
UV8b_04586	COG0529	Catalyzes the synthesis of activated sulfate
UV8b_04649	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UV8b_04649	COG3153	acetyltransferase
UV8b_04670	COG0446	pyridine nucleotide-disulphide oxidoreductase
UV8b_04675	COG5265	(ABC) transporter
UV8b_04707	COG1028	Short-chain dehydrogenase reductase Sdr
UV8b_04729	COG0477	Major facilitator Superfamily
UV8b_04736	COG0481	GTPase activity
UV8b_04784	COG0564	pseudouridine synthase activity
UV8b_04819	COG0738	Major facilitator superfamily
UV8b_04832	COG1011	Hydrolase
UV8b_04923	COG0505	Belongs to the CarA family
UV8b_04972	COG0625	glutathione transferase activity
UV8b_05015	COG0823	Involved in the tonB-independent uptake of proteins
UV8b_05024	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UV8b_05051	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UV8b_05056	COG0626	cystathionine gamma-synthase activity
UV8b_05182	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
UV8b_05203	COG0326	Molecular chaperone. Has ATPase activity
UV8b_05276	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UV8b_05360	COG0022	dehydrogenase e1 component
UV8b_05392	COG0656	L-ascorbic acid biosynthetic process
UV8b_05453	COG0037	tRNA processing
UV8b_05586	COG1028	Short-chain dehydrogenase reductase Sdr
UV8b_05630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UV8b_05642	COG1028	Short-chain dehydrogenase reductase Sdr
UV8b_05682	COG0483	inositol monophosphate 1-phosphatase activity
UV8b_05699	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UV8b_05745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UV8b_05785	COG0484	heat shock protein binding
UV8b_05851	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UV8b_05883	COG0366	Alpha amylase catalytic
UV8b_05884	COG2814	Major facilitator Superfamily
UV8b_05925	COG0174	glutamine synthetase
UV8b_05926	COG3257	ureidoglycine aminohydrolase activity
UV8b_06029	COG2226	methyltransferase
UV8b_06189	COG0513	Belongs to the DEAD box helicase family
UV8b_06194	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UV8b_06317	COG2815	serine threonine protein kinase
UV8b_06317	COG0515	serine threonine protein kinase
UV8b_06327	COG0151	Belongs to the GarS family
UV8b_06367	COG1132	(ABC) transporter
UV8b_06500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
UV8b_06580	COG0237	dephospho-CoA kinase activity
UV8b_06594	COG1501	Belongs to the glycosyl hydrolase 31 family
UV8b_06616	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
UV8b_06634	COG2175	clavaminate synthase activity
UV8b_06726	COG4895	conserved protein (DUF2196)
UV8b_06747	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UV8b_06747	COG0512	Glutamine amidotransferase of anthranilate synthase
UV8b_06818	COG0259	pyridoxamine-phosphate oxidase activity
UV8b_06848	COG1028	Short-chain dehydrogenase reductase Sdr
UV8b_06881	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UV8b_06943	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UV8b_06980	COG2070	2-Nitropropane dioxygenase
UV8b_06982	COG1643	Atp-dependent helicase
UV8b_07088	COG0181	hydroxymethylbilane synthase activity
UV8b_07111	COG0657	acetylesterase activity
UV8b_07180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UV8b_07181	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UV8b_07190	COG0784	Response regulator, receiver
UV8b_07190	COG2205	protein histidine kinase activity
UV8b_07190	COG5002	protein histidine kinase activity
UV8b_07199	COG5265	(ABC) transporter
UV8b_07233	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UV8b_07236	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UV8b_07330	COG1012	belongs to the aldehyde dehydrogenase family
UV8b_07358	COG1418	mRNA catabolic process
UV8b_07385	COG1584	GPR1 FUN34 yaaH family protein
UV8b_07388	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UV8b_07467	COG0107	imidazoleglycerol-phosphate synthase activity
UV8b_07487	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UV8b_07497	COG0142	geranyltranstransferase activity
UV8b_07581	COG0285	dihydrofolate synthase activity
UV8b_07607	COG1643	Atp-dependent helicase
UV8b_07637	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UV8b_07648	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UV8b_07655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UV8b_07657	COG2814	Major facilitator Superfamily
UV8b_07683	COG0515	serine threonine protein kinase
UV8b_07683	COG2815	serine threonine protein kinase
UV8b_07784	COG1368	sulfuric ester hydrolase activity
UV8b_07786	COG3961	Belongs to the TPP enzyme family
UV8b_07863	COG0156	8-amino-7-oxononanoate synthase activity
UV8b_07890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UV8b_07945	COG0519	Catalyzes the synthesis of GMP from XMP
UV8b_07970	COG1131	(ABC) transporter
UV8b_08212	COG3185	4-Hydroxyphenylpyruvate dioxygenase
UV8b_08274	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UV8b_08288	COG2814	Major facilitator Superfamily