locus-tag	class	description
K5L00_00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5L00_00080	COG0516	GMP reductase activity
K5L00_00080	COG0517	IMP dehydrogenase activity
K5L00_00090	COG0012	GTP binding
K5L00_00095	COG4481	Protein conserved in bacteria
K5L00_00100	COG1475	DNA binding
K5L00_00105	COG1192	Involved in chromosome partitioning
K5L00_00110	COG0357	Ribosomal RNA small subunit methyltransferase G
K5L00_00125	COG0445	tRNA wobble uridine modification
K5L00_00130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5L00_00140	COG1438	arginine binding
K5L00_00155	COG2153	protein acetylation
K5L00_00160	COG0018	arginyl-trna synthetase
K5L00_00165	COG1288	antiporter activity
K5L00_00175	COG0549	Belongs to the carbamate kinase family
K5L00_00180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5L00_00185	COG2235	arginine
K5L00_00190	COG1438	arginine binding
K5L00_00200	COG0706	membrane insertase activity
K5L00_00205	COG0594	ribonuclease P activity
K5L00_00210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5L00_00215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5L00_00220	COG0592	DNA-directed DNA polymerase activity
K5L00_00230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5L00_00235	COG0187	DNA topoisomerase II activity
K5L00_00245	COG0360	Binds together with S18 to 16S ribosomal RNA
K5L00_00250	COG0629	single-stranded DNA binding
K5L00_00255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5L00_00260	COG0359	binds to the 23S rRNA
K5L00_00265	COG0305	Participates in initiation and elongation during chromosome replication
K5L00_00270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5L00_00290	COG0488	(ABC) transporter
K5L00_00300	COG0142	geranyltranstransferase activity
K5L00_00315	COG4939	FMN-binding domain protein
K5L00_00335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5L00_00350	COG1609	Transcriptional regulator
K5L00_00355	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5L00_00365	COG1744	ABC transporter substrate-binding protein PnrA-like
K5L00_00370	COG3845	ABC transporter
K5L00_00375	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5L00_00380	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5L00_00385	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5L00_00395	COG0813	purine-nucleoside phosphorylase activity
K5L00_00415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5L00_00420	COG0477	Major facilitator Superfamily
K5L00_00435	COG1686	Belongs to the peptidase S11 family
K5L00_00440	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K5L00_00445	COG1242	4 iron, 4 sulfur cluster binding
K5L00_00450	COG0671	phosphoesterase, PA-phosphatase related
K5L00_00465	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5L00_00465	COG1388	LysM domain
K5L00_00470	COG0495	leucyl-tRNA aminoacylation
K5L00_00475	COG2244	polysaccharide biosynthetic process
K5L00_00480	COG1187	pseudouridine synthase activity
K5L00_00485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5L00_00510	COG1126	abc transporter atp-binding protein
K5L00_00515	COG0765	amino acid transport
K5L00_00525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5L00_00540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5L00_00550	COG1653	transport
K5L00_00555	COG1175	transmembrane transport
K5L00_00560	COG0395	ABC-type sugar transport system, permease component
K5L00_00565	COG3842	ATPase activity
K5L00_00585	COG5294	Protein conserved in bacteria
K5L00_00630	COG1396	sequence-specific DNA binding
K5L00_00635	COG3620	sequence-specific DNA binding
K5L00_00645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5L00_00650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5L00_00675	COG4808	Protein conserved in bacteria
K5L00_00680	COG1733	regulation of RNA biosynthetic process
K5L00_00690	COG1278	Cold shock
K5L00_00700	COG0686	Belongs to the AlaDH PNT family
K5L00_00705	COG1764	response to oxidative stress
K5L00_00730	COG1461	Dihydroxyacetone kinase
K5L00_00765	COG0659	secondary active sulfate transmembrane transporter activity
K5L00_00770	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5L00_00780	COG1269	ATP hydrolysis coupled proton transport
K5L00_00785	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5L00_00795	COG1527	subunit (C
K5L00_00800	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
K5L00_00805	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5L00_00810	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K5L00_00815	COG1394	ATPase activity, coupled to movement of substances
K5L00_00825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5L00_00830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5L00_00855	COG1733	regulation of RNA biosynthetic process
K5L00_00920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5L00_00930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5L00_00940	COG0039	L-malate dehydrogenase activity
K5L00_00945	COG0193	aminoacyl-tRNA hydrolase activity
K5L00_00950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5L00_00955	COG2244	polysaccharide biosynthetic process
K5L00_00960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5L00_00970	COG1098	S1 RNA binding domain
K5L00_00975	COG0037	tRNA processing
K5L00_00980	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5L00_00985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5L00_00990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5L00_00995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5L00_01000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5L00_01180	COG4463	regulation of RNA biosynthetic process
K5L00_01185	COG0542	response to heat
K5L00_01195	COG0826	peptidase U32
K5L00_01200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5L00_01205	COG1271	oxidase subunit
K5L00_01210	COG1294	oxidase, subunit
K5L00_01215	COG4988	ABC transporter
K5L00_01220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5L00_01235	COG1054	Belongs to the UPF0176 family
K5L00_01285	COG0363	glucosamine-6-phosphate deaminase activity
K5L00_01290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5L00_01320	COG0798	PFAM Bile acid sodium symporter
K5L00_01375	COG1442	glycosyl transferase family 8
K5L00_01400	COG0640	Transcriptional regulator
K5L00_01405	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5L00_01435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5L00_01445	COG1609	Transcriptional regulator
K5L00_01455	COG0488	(ABC) transporter
K5L00_01465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5L00_01475	COG0628	permease
K5L00_01490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5L00_01495	COG1426	Protein conserved in bacteria
K5L00_01500	COG0300	oxidoreductase activity
K5L00_01505	COG0612	Peptidase, M16
K5L00_01510	COG0612	Peptidase, M16
K5L00_01515	COG1970	mechanosensitive ion channel activity
K5L00_01520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5L00_01530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5L00_01535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5L00_01540	COG1121	(ABC) transporter
K5L00_01545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5L00_01555	COG1177	transmembrane transport
K5L00_01560	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5L00_01565	COG3842	ATPase activity
K5L00_01575	COG0604	alcohol dehydrogenase
K5L00_01630	COG1473	amidohydrolase
K5L00_01635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5L00_01640	COG0038	chloride channel
K5L00_01650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5L00_01660	COG3290	protein histidine kinase activity
K5L00_01665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5L00_01670	COG0708	Exodeoxyribonuclease III
K5L00_01690	COG0802	atpase or kinase
K5L00_01700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5L00_01710	COG2190	(PTS) system
K5L00_01710	COG1263	PTS System
K5L00_01710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_01720	COG1609	Transcriptional regulator
K5L00_01730	COG0280	phosphate acetyltransferase
K5L00_01740	COG0561	phosphatase activity
K5L00_01750	COG0025	NhaP-type Na H and K H
K5L00_01755	COG1278	Cold shock
K5L00_01775	COG0745	RESPONSE REGULATOR receiver
K5L00_01780	COG5002	protein histidine kinase activity
K5L00_01785	COG2433	Pfam Transposase IS66
K5L00_01810	COG1131	(ABC) transporter
K5L00_01855	COG1215	transferase activity, transferring glycosyl groups
K5L00_01865	COG2188	Transcriptional regulator
K5L00_01890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5L00_01915	COG2217	Heavy metal translocating P-type atpase
K5L00_01920	COG1285	pathogenesis
K5L00_01925	COG0251	oxidation-reduction process
K5L00_01945	COG2390	Transcriptional regulator
K5L00_01950	COG0583	DNA-binding transcription factor activity
K5L00_01955	COG4166	transmembrane transport
K5L00_01960	COG0402	S-adenosylhomocysteine deaminase activity
K5L00_01965	COG0402	S-adenosylhomocysteine deaminase activity
K5L00_01990	COG4869	propanediol catabolic process
K5L00_02000	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
K5L00_02010	COG1129	ABC transporter
K5L00_02015	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5L00_02025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5L00_02030	COG1349	DNA-binding transcription factor activity
K5L00_02035	COG0235	Class ii aldolase
K5L00_02050	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K5L00_02060	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5L00_02070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5L00_02080	COG4335	DNA alkylation repair
K5L00_02110	COG3448	diguanylate cyclase activity
K5L00_02110	COG4175	Glycine betaine
K5L00_02145	COG1132	(ABC) transporter
K5L00_02150	COG1132	(ABC) transporter
K5L00_02155	COG0765	amino acid transport
K5L00_02160	COG1126	abc transporter atp-binding protein
K5L00_02165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5L00_02175	COG0435	Glutathione S-transferase
K5L00_02185	COG3022	response to hydroperoxide
K5L00_02190	COG2252	PERMEase
K5L00_02210	COG5504	Zn-dependent protease
K5L00_02215	COG2723	6-phospho-beta-galactosidase activity
K5L00_02220	COG1940	carbohydrate kinase activity
K5L00_02230	COG3973	AAA domain
K5L00_02250	COG0531	amino acid
K5L00_02260	COG1757	Na H antiporter
K5L00_02280	COG4166	transmembrane transport
K5L00_02295	COG1136	(ABC) transporter
K5L00_02325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5L00_02335	COG3037	sugar-specific permease SgaT UlaA
K5L00_02340	COG4821	SIS domain
K5L00_02365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5L00_02370	COG1061	Type III restriction enzyme res subunit
K5L00_02375	COG1002	Type II restriction enzyme, methylase subunits
K5L00_02385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5L00_02385	COG0519	Catalyzes the synthesis of GMP from XMP
K5L00_02390	COG1072	(Pantothenic acid kinase))
K5L00_02395	COG2755	lipolytic protein G-D-S-L family
K5L00_02400	COG2813	Specifically methylates the guanine in position
K5L00_02405	COG0085	RNA polymerase activity
K5L00_02410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5L00_02425	COG3711	transcriptional antiterminator
K5L00_02430	COG2190	(PTS) system
K5L00_02430	COG1263	PTS System
K5L00_02430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_02435	COG2723	6-phospho-beta-galactosidase activity
K5L00_02450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5L00_02455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5L00_02465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5L00_02480	COG3158	transport of potassium into the cell
K5L00_02485	COG0756	dUTP diphosphatase activity
K5L00_02495	COG4956	integral membrane protein (PIN domain superfamily)
K5L00_02500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5L00_02505	COG1045	serine acetyltransferase
K5L00_02510	COG0215	cysteine-tRNA ligase activity
K5L00_02515	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K5L00_02520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5L00_02525	COG3688	RNA-binding protein containing a PIN domain
K5L00_02535	COG4466	Protein conserved in bacteria
K5L00_02540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5L00_02545	COG4980	gas vesicle protein
K5L00_02550	COG0537	adenosine 5'-monophosphoramidase activity
K5L00_02555	COG1131	(ABC) transporter
K5L00_02560	COG4473	ABC transporter
K5L00_02565	COG0510	thiamine kinase activity
K5L00_02570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5L00_02575	COG1611	Belongs to the LOG family
K5L00_02580	COG1694	Mazg nucleotide pyrophosphohydrolase
K5L00_02590	COG1363	Peptidase, m42
K5L00_02595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5L00_02605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5L00_02610	COG4472	Bacterial protein of unknown function (DUF965)
K5L00_02615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5L00_02630	COG3906	Belongs to the UPF0473 family
K5L00_02635	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5L00_02650	COG1193	negative regulation of DNA recombination
K5L00_02655	COG3118	belongs to the thioredoxin family
K5L00_02660	COG0322	excinuclease ABC activity
K5L00_02685	COG4152	abc transporter atp-binding protein
K5L00_02690	COG1668	transmembrane transport
K5L00_02715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5L00_02720	COG2116	formate transmembrane transporter activity
K5L00_02725	COG0561	phosphatase activity
K5L00_02730	COG0242	peptide deformylase activity
K5L00_02735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5L00_02740	COG1185	polyribonucleotide nucleotidyltransferase activity
K5L00_02755	COG0383	alpha-mannosidase activity
K5L00_02765	COG1609	Transcriptional regulator
K5L00_02775	COG1940	carbohydrate kinase activity
K5L00_02785	COG1649	PFAM Uncharacterised BCR, COG1649
K5L00_02805	COG1309	transcriptional regulator
K5L00_02810	COG2376	Dihydroxyacetone kinase
K5L00_02815	COG1461	Dihydroxyacetone kinase
K5L00_02820	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K5L00_02825	COG0371	Dehydrogenase
K5L00_02830	COG2376	Dihydroxyacetone kinase
K5L00_02855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5L00_02860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5L00_02865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5L00_02870	COG0028	Belongs to the TPP enzyme family
K5L00_02880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5L00_02885	COG2011	ABC-type metal ion transport system permease component
K5L00_02920	COG0642	Histidine kinase
K5L00_02930	COG1136	(ABC) transporter
K5L00_02935	COG0577	efflux transmembrane transporter activity
K5L00_02940	COG1363	Peptidase, m42
K5L00_02955	COG0577	efflux transmembrane transporter activity
K5L00_02960	COG1234	tRNA 3'-trailer cleavage
K5L00_02965	COG0095	Lipoate-protein ligase
K5L00_02970	COG0740	serine-type endopeptidase activity
K5L00_02975	COG0180	Tryptophanyl-tRNA synthetase
K5L00_02980	COG1393	Belongs to the ArsC family
K5L00_02985	COG4862	establishment of competence for transformation
K5L00_02995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5L00_03000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5L00_03005	COG1780	Probably involved in ribonucleotide reductase function
K5L00_03010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5L00_03030	COG0745	RESPONSE REGULATOR receiver
K5L00_03035	COG5002	protein histidine kinase activity
K5L00_03050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5L00_03055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5L00_03060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5L00_03065	COG1160	GTP binding
K5L00_03110	COG2267	carboxylic ester hydrolase activity
K5L00_03120	COG1573	uracil-dna glycosylase
K5L00_03135	COG1131	(ABC) transporter
K5L00_03155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K5L00_03160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5L00_03165	COG2169	Transcriptional regulator
K5L00_03170	COG4166	transmembrane transport
K5L00_03185	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5L00_03190	COG1175	transmembrane transport
K5L00_03195	COG0395	ABC-type sugar transport system, permease component
K5L00_03215	COG1737	Transcriptional regulator
K5L00_03220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5L00_03225	COG4166	transmembrane transport
K5L00_03235	COG0673	inositol 2-dehydrogenase activity
K5L00_03245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5L00_03255	COG1737	Transcriptional regulator
K5L00_03260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_03265	COG2723	6-phospho-beta-galactosidase activity
K5L00_03270	COG1940	carbohydrate kinase activity
K5L00_03275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_03280	COG2188	Transcriptional regulator
K5L00_03285	COG2723	6-phospho-beta-galactosidase activity
K5L00_03300	COG0789	Transcriptional regulator
K5L00_03305	COG0667	Aldo Keto reductase
K5L00_03310	COG1846	Transcriptional regulator
K5L00_03315	COG2814	Major facilitator Superfamily
K5L00_03320	COG1132	(ABC) transporter
K5L00_03335	COG0745	RESPONSE REGULATOR receiver
K5L00_03340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K5L00_03350	COG5002	protein histidine kinase activity
K5L00_03355	COG0745	RESPONSE REGULATOR receiver
K5L00_03360	COG0577	efflux transmembrane transporter activity
K5L00_03365	COG1136	(ABC) transporter
K5L00_03370	COG1187	pseudouridine synthase activity
K5L00_03375	COG0217	transcriptional regulatory protein
K5L00_03385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_03400	COG1132	(ABC) transporter
K5L00_03405	COG1132	(ABC) transporter
K5L00_03415	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5L00_03450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5L00_03470	COG0395	ABC-type sugar transport system, permease component
K5L00_03475	COG1175	transmembrane transport
K5L00_03485	COG0564	pseudouridine synthase activity
K5L00_03490	COG4684	Psort location CytoplasmicMembrane, score
K5L00_03510	COG3730	PTS system glucitol sorbitol-specific
K5L00_03515	COG3732	PTS system glucitol sorbitol-specific
K5L00_03530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5L00_03540	COG0604	alcohol dehydrogenase
K5L00_03560	COG2169	Transcriptional regulator
K5L00_03570	COG0698	ribose 5-phosphate isomerase
K5L00_03585	COG3775	system Galactitol-specific IIC component
K5L00_03590	COG0235	Class ii aldolase
K5L00_03595	COG3414	Phosphotransferase system galactitol-specific IIB component
K5L00_03600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5L00_03605	COG0022	dehydrogenase e1 component
K5L00_03635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5L00_03645	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K5L00_03650	COG0352	thiamine-phosphate diphosphorylase activity
K5L00_03655	COG0351	phosphomethylpyrimidine kinase
K5L00_03660	COG0531	amino acid
K5L00_03665	COG0662	Cupin 2, conserved barrel domain protein
K5L00_03695	COG3639	organic phosphonate transmembrane transporter activity
K5L00_03700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K5L00_03720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5L00_03735	COG0159	tryptophan synthase activity
K5L00_03750	COG0513	Belongs to the DEAD box helicase family
K5L00_03755	COG0105	UTP biosynthetic process
K5L00_03775	COG3976	FMN-binding domain protein
K5L00_03775	COG0431	NADPH-dependent FMN reductase
K5L00_03775	COG1053	succinate dehydrogenase
K5L00_03800	COG1305	Transglutaminase-like
K5L00_03810	COG1609	Transcriptional regulator
K5L00_03820	COG1869	D-ribose catabolic process
K5L00_03825	COG4975	Glucose uptake
K5L00_03860	COG1263	PTS System
K5L00_03860	COG2190	(PTS) system
K5L00_03860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_03865	COG3711	transcriptional antiterminator
K5L00_03870	COG2213	PTS system mannitol-specific
K5L00_03875	COG3711	transcriptional antiterminator
K5L00_03880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5L00_03885	COG2213	PTS system mannitol-specific
K5L00_03890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5L00_03895	COG0246	Mannitol dehydrogenase
K5L00_03940	COG0745	RESPONSE REGULATOR receiver
K5L00_03950	COG0367	asparagine synthase
K5L00_03970	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K5L00_03980	COG4946	Tricorn protease homolog
K5L00_03980	COG1506	peptidase
K5L00_03980	COG0823	Involved in the tonB-independent uptake of proteins
K5L00_03990	COG1126	abc transporter atp-binding protein
K5L00_03995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5L00_04000	COG0765	amino acid transport
K5L00_04005	COG0765	amino acid transport
K5L00_04015	COG1268	BioY protein
K5L00_04030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5L00_04035	COG2011	ABC-type metal ion transport system permease component
K5L00_04040	COG1464	Belongs to the NlpA lipoprotein family
K5L00_04050	COG1486	melibiose metabolic process
K5L00_04055	COG1609	Transcriptional regulator
K5L00_04070	COG3404	Formiminotransferase-cyclodeaminase
K5L00_04075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K5L00_04085	COG0531	amino acid
K5L00_04095	COG0124	histidyl-tRNA synthetase
K5L00_04100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5L00_04105	COG0456	acetyltransferase
K5L00_04110	COG1597	lipid kinase activity
K5L00_04115	COG1228	amidohydrolase
K5L00_04120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5L00_04145	COG1070	Carbohydrate kinase
K5L00_04150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5L00_04155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5L00_04160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5L00_04175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5L00_04180	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5L00_04190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5L00_04200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5L00_04205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5L00_04210	COG0138	bifunctional purine biosynthesis protein purh
K5L00_04225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5L00_04230	COG1534	Rna-binding protein
K5L00_04235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5L00_04245	COG0799	negative regulation of ribosome biogenesis
K5L00_04250	COG2226	methyltransferase
K5L00_04255	COG1323	Belongs to the UPF0348 family
K5L00_04275	COG3655	Transcriptional regulator
K5L00_04285	COG1304	FMN binding
K5L00_04300	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5L00_04305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5L00_04310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5L00_04325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5L00_04330	COG1121	(ABC) transporter
K5L00_04335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5L00_04350	COG0300	oxidoreductase activity
K5L00_04360	COG0772	Belongs to the SEDS family
K5L00_04370	COG1393	Belongs to the ArsC family
K5L00_04375	COG0509	glycine decarboxylation via glycine cleavage system
K5L00_04380	COG0716	FMN binding
K5L00_04390	COG3706	GGDEF domain
K5L00_04400	COG2738	Putative neutral zinc metallopeptidase
K5L00_04405	COG2508	Transcriptional regulator
K5L00_04410	COG0590	tRNA wobble adenosine to inosine editing
K5L00_04420	COG1428	Deoxynucleoside kinase
K5L00_04445	COG1653	transport
K5L00_04450	COG1175	transmembrane transport
K5L00_04455	COG0395	ABC-type sugar transport system, permease component
K5L00_04460	COG0366	Alpha amylase catalytic
K5L00_04465	COG1960	acyl-CoA dehydrogenase activity
K5L00_04470	COG0583	DNA-binding transcription factor activity
K5L00_04475	COG0183	Belongs to the thiolase family
K5L00_04480	COG1960	acyl-CoA dehydrogenase activity
K5L00_04485	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5L00_04490	COG1024	Enoyl-CoA hydratase
K5L00_04495	COG0427	acetyl-CoA hydrolase
K5L00_04500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5L00_04505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5L00_04510	COG0351	phosphomethylpyrimidine kinase
K5L00_04515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5L00_04550	COG0504	CTP synthase activity
K5L00_04570	COG0577	efflux transmembrane transporter activity
K5L00_04570	COG1136	(ABC) transporter
K5L00_04575	COG0577	efflux transmembrane transporter activity
K5L00_04575	COG1136	(ABC) transporter
K5L00_04590	COG3425	synthase
K5L00_04595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5L00_04600	COG1363	Peptidase, m42
K5L00_04615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5L00_04630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_04645	COG2807	transmembrane transport
K5L00_04650	COG2807	transmembrane transport
K5L00_04655	COG1396	sequence-specific DNA binding
K5L00_04675	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K5L00_04680	COG1074	ATP-dependent DNA helicase activity
K5L00_04695	COG3853	Toxic anion resistance protein (TelA)
K5L00_04700	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K5L00_04715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5L00_04720	COG1335	isochorismatase
K5L00_04725	COG2855	membrane
K5L00_04740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5L00_04745	COG2706	6-phosphogluconolactonase activity
K5L00_04760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5L00_04765	COG1435	thymidine kinase activity
K5L00_04770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5L00_04775	COG2890	protein-(glutamine-N5) methyltransferase activity
K5L00_04780	COG0009	L-threonylcarbamoyladenylate synthase
K5L00_04785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5L00_04790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5L00_04805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5L00_04810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5L00_04830	COG0116	Belongs to the methyltransferase superfamily
K5L00_04835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5L00_04840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5L00_04845	COG3588	fructose-bisphosphate aldolase
K5L00_04850	COG2188	Transcriptional regulator
K5L00_04855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_04870	COG3964	amidohydrolase
K5L00_04890	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5L00_04905	COG1131	(ABC) transporter
K5L00_04915	COG2365	Tyrosine phosphatase family
K5L00_04920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5L00_04925	COG0737	Belongs to the 5'-nucleotidase family
K5L00_04930	COG4470	Protein conserved in bacteria
K5L00_04935	COG0647	UMP catabolic process
K5L00_04945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5L00_04950	COG0492	ferredoxin-NADP+ reductase activity
K5L00_04965	COG1132	(ABC) transporter
K5L00_04980	COG1482	cell wall glycoprotein biosynthetic process
K5L00_04985	COG1609	Transcriptional regulator
K5L00_04990	COG0686	Belongs to the AlaDH PNT family
K5L00_04995	COG3442	glutamine amidotransferase
K5L00_05000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5L00_05010	COG0601	transmembrane transport
K5L00_05015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5L00_05020	COG0444	Belongs to the ABC transporter superfamily
K5L00_05025	COG4608	Belongs to the ABC transporter superfamily
K5L00_05035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5L00_05050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5L00_05055	COG0328	RNA-DNA hybrid ribonuclease activity
K5L00_05065	COG1278	Cold shock
K5L00_05070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5L00_05075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5L00_05080	COG0735	belongs to the Fur family
K5L00_05205	COG1696	Membrane protein involved in D-alanine export
K5L00_05210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5L00_05215	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K5L00_05225	COG2391	methyltransferase activity
K5L00_05230	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5L00_05235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5L00_05240	COG4521	taurine ABC transporter
K5L00_05245	COG1116	anion transmembrane transporter activity
K5L00_05250	COG0741	lytic transglycosylase activity
K5L00_05255	COG0726	polysaccharide deacetylase
K5L00_05260	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K5L00_05260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5L00_05265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5L00_05270	COG1175	transmembrane transport
K5L00_05275	COG0395	ABC-type sugar transport system, permease component
K5L00_05280	COG1653	transport
K5L00_05290	COG2972	Histidine kinase
K5L00_05295	COG2207	Transcriptional regulator
K5L00_05295	COG4753	response regulator
K5L00_05310	COG2824	Alkylphosphonate utilization operon protein PhnA
K5L00_05315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5L00_05320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5L00_05330	COG4585	Histidine kinase
K5L00_05335	COG2197	response regulator
K5L00_05340	COG0569	domain protein
K5L00_05345	COG4841	protein insertion into membrane
K5L00_05355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5L00_05360	COG4838	Belongs to the UPF0358 family
K5L00_05365	COG0772	Belongs to the SEDS family
K5L00_05370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K5L00_05380	COG3679	Belongs to the UPF0342 family
K5L00_05385	COG4471	UPF0298 protein
K5L00_05395	COG0488	(ABC) transporter
K5L00_05405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5L00_05410	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5L00_05415	COG1253	flavin adenine dinucleotide binding
K5L00_05420	COG0494	nUDIX hydrolase
K5L00_05425	COG1214	PFAM Peptidase M22, glycoprotease
K5L00_05435	COG0456	acetyltransferase
K5L00_05440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5L00_05450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5L00_05460	COG0517	IMP dehydrogenase activity
K5L00_05470	COG0668	transmembrane transport
K5L00_05485	COG1609	Transcriptional regulator
K5L00_05490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5L00_05495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5L00_05500	COG3763	UPF0154 protein
K5L00_05505	COG1132	(ABC) transporter
K5L00_05510	COG1132	(ABC) transporter
K5L00_05520	COG1609	Transcriptional regulator
K5L00_05525	COG0366	Alpha amylase catalytic
K5L00_05535	COG2182	Extracellular solute-binding protein
K5L00_05540	COG1175	transmembrane transport
K5L00_05545	COG3833	ABC-type maltose transport systems, permease component
K5L00_05555	COG0772	Belongs to the SEDS family
K5L00_05560	COG0534	Mate efflux family protein
K5L00_05570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5L00_05575	COG0640	Transcriptional regulator
K5L00_05585	COG0083	homoserine kinase activity
K5L00_05595	COG1254	Belongs to the acylphosphatase family
K5L00_05600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5L00_05610	COG1733	regulation of RNA biosynthetic process
K5L00_05615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5L00_05620	COG0072	phenylalanine-tRNA ligase activity
K5L00_05620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5L00_05625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5L00_05630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5L00_05635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5L00_05645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5L00_05650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5L00_05660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5L00_05670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5L00_05680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5L00_05685	COG0439	Biotin carboxylase
K5L00_05690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5L00_05695	COG0825	malonyl-CoA metabolic process
K5L00_05705	COG2151	metal-sulfur cluster biosynthetic enzyme
K5L00_05745	COG1523	belongs to the glycosyl hydrolase 13 family
K5L00_05765	COG0737	Belongs to the 5'-nucleotidase family
K5L00_05770	COG0737	Belongs to the 5'-nucleotidase family
K5L00_05810	COG5566	PFAM Mor transcription activator
K5L00_05815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5L00_05820	COG1073	alpha beta
K5L00_05825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5L00_05880	COG0745	RESPONSE REGULATOR receiver
K5L00_05885	COG3850	Histidine kinase
K5L00_05885	COG5002	protein histidine kinase activity
K5L00_05890	COG4476	Belongs to the UPF0223 family
K5L00_05895	COG0483	inositol monophosphate 1-phosphatase activity
K5L00_05900	COG1217	gtp-binding protein TYPA
K5L00_05915	COG0210	DNA helicase
K5L00_05920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5L00_05925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5L00_05930	COG0154	amidase activity
K5L00_05935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5L00_05940	COG1597	lipid kinase activity
K5L00_05945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5L00_05980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5L00_05995	COG2608	mercury ion transmembrane transporter activity
K5L00_06035	COG2030	dehydratase
K5L00_06050	COG1368	sulfuric ester hydrolase activity
K5L00_06055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5L00_06060	COG0710	3-dehydroquinate dehydratase activity
K5L00_06065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5L00_06070	COG2081	HI0933 family
K5L00_06075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5L00_06080	COG0166	Belongs to the GPI family
K5L00_06105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5L00_06115	COG0670	Belongs to the BI1 family
K5L00_06120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5L00_06120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5L00_06125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5L00_06130	COG0237	dephospho-CoA kinase activity
K5L00_06135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5L00_06145	COG1484	DNA-dependent DNA replication
K5L00_06155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5L00_06160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5L00_06180	COG0765	amino acid transport
K5L00_06185	COG1126	abc transporter atp-binding protein
K5L00_06190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5L00_06215	COG0737	Belongs to the 5'-nucleotidase family
K5L00_06235	COG0187	DNA topoisomerase II activity
K5L00_06240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5L00_06245	COG1882	Formate acetyltransferase
K5L00_06250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5L00_06265	COG2076	Multidrug Resistance protein
K5L00_06270	COG2076	Multidrug Resistance protein
K5L00_06275	COG1227	inorganic diphosphatase activity
K5L00_06285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5L00_06295	COG0564	pseudouridine synthase activity
K5L00_06305	COG2233	PERMEase
K5L00_06310	COG0540	Belongs to the ATCase OTCase family
K5L00_06315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5L00_06320	COG0505	Belongs to the CarA family
K5L00_06325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5L00_06330	COG0543	2 iron, 2 sulfur cluster binding
K5L00_06335	COG0167	dihydroorotate dehydrogenase activity
K5L00_06340	COG0284	orotidine-5'-phosphate decarboxylase activity
K5L00_06370	COG1278	Cold shock
K5L00_06375	COG0531	amino acid
K5L00_06385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K5L00_06405	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5L00_06410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5L00_06440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5L00_06470	COG0577	efflux transmembrane transporter activity
K5L00_06470	COG1136	(ABC) transporter
K5L00_06470	COG0577	efflux transmembrane transporter activity
K5L00_06470	COG1136	(ABC) transporter
K5L00_06475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5L00_06495	COG0768	penicillin binding
K5L00_06500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5L00_06505	COG1472	Belongs to the glycosyl hydrolase 3 family
K5L00_06520	COG4895	conserved protein (DUF2196)
K5L00_06540	COG3328	transposase activity
K5L00_06595	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5L00_06595	COG1388	LysM domain
K5L00_06805	COG3935	DnaD domain protein
K5L00_06820	COG3723	Recombinational DNA repair protein, rece pathway
K5L00_06825	COG5377	YqaJ viral recombinase family
K5L00_06880	COG1396	sequence-specific DNA binding
K5L00_06910	COG4974	Belongs to the 'phage' integrase family
K5L00_06915	COG0481	GTPase activity
K5L00_06925	COG0542	response to heat
K5L00_06930	COG0456	acetyltransferase
K5L00_06935	COG0463	Glycosyl transferase, family 2
K5L00_06945	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5L00_06950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5L00_06955	COG2384	SAM-dependent methyltransferase
K5L00_06960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5L00_06965	COG0358	DNA primase activity
K5L00_06970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5L00_06975	COG0515	serine threonine protein kinase
K5L00_06980	COG1136	(ABC) transporter
K5L00_06985	COG0577	efflux transmembrane transporter activity
K5L00_06990	COG0751	glycine-tRNA ligase activity
K5L00_06995	COG0752	glycyl-tRNA synthetase alpha subunit
K5L00_07000	COG1381	Involved in DNA repair and RecF pathway recombination
K5L00_07005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5L00_07010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5L00_07015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5L00_07025	COG1702	phosphate starvation-inducible protein PhoH
K5L00_07035	COG0735	belongs to the Fur family
K5L00_07040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5L00_07055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5L00_07060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5L00_07065	COG4974	Belongs to the 'phage' integrase family
K5L00_07070	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K5L00_07075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5L00_07080	COG0758	DNA mediated transformation
K5L00_07085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5L00_07090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5L00_07100	COG0793	Belongs to the peptidase S41A family
K5L00_07100	COG3409	Peptidoglycan-binding domain 1 protein
K5L00_07105	COG4479	Belongs to the UPF0346 family
K5L00_07120	COG2755	lipolytic protein G-D-S-L family
K5L00_07125	COG1307	EDD domain protein, DegV family
K5L00_07130	COG1272	protein, Hemolysin III
K5L00_07145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5L00_07150	COG0488	(ABC) transporter
K5L00_07165	COG0617	tRNA 3'-terminal CCA addition
K5L00_07170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5L00_07175	COG1694	Mazg nucleotide pyrophosphohydrolase
K5L00_07180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5L00_07195	COG3426	butyrate kinase activity
K5L00_07200	COG0280	phosphate acetyltransferase
K5L00_07230	COG0583	DNA-binding transcription factor activity
K5L00_07240	COG5582	Belongs to the UPF0302 family
K5L00_07265	COG1160	GTP binding
K5L00_07270	COG0539	negative regulation of cytoplasmic translation
K5L00_07275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5L00_07280	COG1134	teichoic acid transport
K5L00_07280	COG1388	LysM domain
K5L00_07285	COG0514	ATP-dependent DNA helicase (RecQ)
K5L00_07300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5L00_07300	COG2755	lipolytic protein G-D-S-L family
K5L00_07310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5L00_07315	COG1187	pseudouridine synthase activity
K5L00_07320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5L00_07325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5L00_07330	COG4974	Belongs to the 'phage' integrase family
K5L00_07345	COG0735	belongs to the Fur family
K5L00_07350	COG2996	Protein conserved in bacteria
K5L00_07365	COG2814	Major facilitator Superfamily
K5L00_07375	COG0205	6-phosphofructokinase activity
K5L00_07380	COG0587	DNA-directed DNA polymerase activity
K5L00_07390	COG2814	Major facilitator Superfamily
K5L00_07400	COG2252	PERMEase
K5L00_07405	COG1725	Transcriptional regulator
K5L00_07410	COG1131	(ABC) transporter
K5L00_07435	COG0577	efflux transmembrane transporter activity
K5L00_07445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5L00_07450	COG2267	carboxylic ester hydrolase activity
K5L00_07455	COG2153	protein acetylation
K5L00_07460	COG2910	NAD(P)H-binding
K5L00_07465	COG1959	2 iron, 2 sulfur cluster binding
K5L00_07470	COG0513	Belongs to the DEAD box helicase family
K5L00_07480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5L00_07490	COG1307	EDD domain protein, DegV family
K5L00_07500	COG0077	Prephenate dehydratase
K5L00_07505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5L00_07515	COG0287	Prephenate dehydrogenase
K5L00_07520	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5L00_07530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5L00_07535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5L00_07545	COG0588	phosphoglycerate mutase activity
K5L00_07575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5L00_07580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5L00_07585	COG0509	glycine decarboxylation via glycine cleavage system
K5L00_07590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5L00_07595	COG0477	Major facilitator Superfamily
K5L00_07600	COG4166	transmembrane transport
K5L00_07605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5L00_07610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5L00_07625	COG5002	protein histidine kinase activity
K5L00_07630	COG0745	RESPONSE REGULATOR receiver
K5L00_07635	COG0114	fumarate hydratase activity
K5L00_07640	COG0281	malic enzyme
K5L00_07645	COG1027	Aspartate ammonia-lyase
K5L00_07655	COG4753	response regulator
K5L00_07655	COG2207	Transcriptional regulator
K5L00_07675	COG0772	Belongs to the SEDS family
K5L00_07685	COG1609	Transcriptional regulator
K5L00_07695	COG0745	RESPONSE REGULATOR receiver
K5L00_07705	COG1136	(ABC) transporter
K5L00_07710	COG0577	efflux transmembrane transporter activity
K5L00_07715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5L00_07720	COG1263	PTS System
K5L00_07720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_07720	COG2190	(PTS) system
K5L00_07725	COG3711	transcriptional antiterminator
K5L00_07735	COG0436	Aminotransferase
K5L00_07740	COG1522	sequence-specific DNA binding
K5L00_07745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5L00_07765	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K5L00_07775	COG3711	transcriptional antiterminator
K5L00_07780	COG2723	6-phospho-beta-galactosidase activity
K5L00_07785	COG1263	PTS System
K5L00_07785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_07785	COG2190	(PTS) system
K5L00_07790	COG1764	response to oxidative stress
K5L00_07795	COG0335	large ribosomal subunit rRNA binding
K5L00_07800	COG0336	Belongs to the RNA methyltransferase TrmD family
K5L00_07805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5L00_07815	COG1837	Belongs to the UPF0109 family
K5L00_07825	COG1131	(ABC) transporter
K5L00_07840	COG0745	RESPONSE REGULATOR receiver
K5L00_07845	COG2205	protein histidine kinase activity
K5L00_07860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5L00_07865	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K5L00_07870	COG5002	protein histidine kinase activity
K5L00_07875	COG0745	RESPONSE REGULATOR receiver
K5L00_07880	COG1132	(ABC) transporter
K5L00_07885	COG1132	(ABC) transporter
K5L00_07890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5L00_07900	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5L00_07905	COG0484	heat shock protein binding
K5L00_07910	COG0443	Heat shock 70 kDa protein
K5L00_07915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5L00_07920	COG1420	regulation of RNA biosynthetic process
K5L00_07925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5L00_07930	COG0196	riboflavin kinase activity
K5L00_07935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5L00_07940	COG1363	Peptidase, m42
K5L00_07945	COG0673	inositol 2-dehydrogenase activity
K5L00_07955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5L00_07970	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K5L00_07975	COG0195	Participates in both transcription termination and antitermination
K5L00_07980	COG0779	Required for maturation of 30S ribosomal subunits
K5L00_07985	COG1408	metallophosphoesterase
K5L00_07995	COG0442	prolyl-tRNA aminoacylation
K5L00_08000	COG0750	zinc metalloprotease
K5L00_08005	COG4589	Belongs to the CDS family
K5L00_08010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5L00_08015	COG0233	cytoplasmic translational termination
K5L00_08020	COG0528	UMP kinase activity
K5L00_08025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5L00_08030	COG0052	Belongs to the universal ribosomal protein uS2 family
K5L00_08035	COG0588	phosphoglycerate mutase activity
K5L00_08050	COG0789	Transcriptional regulator
K5L00_08060	COG1968	undecaprenyl-diphosphatase activity
K5L00_08065	COG2217	Heavy metal translocating P-type atpase
K5L00_08080	COG1307	EDD domain protein, DegV family
K5L00_08090	COG1466	dna polymerase III delta subunit
K5L00_08095	COG0658	competence protein
K5L00_08095	COG2333	competence protein COMEC
K5L00_08100	COG2131	deaminase
K5L00_08105	COG1555	photosystem II stabilization
K5L00_08110	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5L00_08115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5L00_08120	COG0742	ribosomal rna small subunit methyltransferase
K5L00_08125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5L00_08140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5L00_08150	COG0789	Transcriptional regulator
K5L00_08155	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K5L00_08160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5L00_08165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5L00_08170	COG0584	glycerophosphoryl diester phosphodiesterase
K5L00_08180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5L00_08185	COG1940	carbohydrate kinase activity
K5L00_08195	COG0457	Tetratricopeptide repeat
K5L00_08195	COG0705	Rhomboid family
K5L00_08200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5L00_08310	COG0740	serine-type endopeptidase activity
K5L00_08425	COG1196	nuclear chromosome segregation
K5L00_08475	COG3561	AntA/AntB antirepressor
K5L00_08490	COG1396	sequence-specific DNA binding
K5L00_08510	COG0582	viral genome integration into host DNA
K5L00_08515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5L00_08520	COG0768	penicillin binding
K5L00_08525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5L00_08535	COG1131	(ABC) transporter
K5L00_08540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5L00_08550	COG0577	efflux transmembrane transporter activity
K5L00_08555	COG1136	(ABC) transporter
K5L00_08560	COG0025	NhaP-type Na H and K H
K5L00_08565	COG1280	lysine exporter protein (LysE YggA)
K5L00_08565	COG1674	ftsk spoiiie
K5L00_08570	COG1012	belongs to the aldehyde dehydrogenase family
K5L00_08585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5L00_08595	COG0482	sulfurtransferase activity
K5L00_08600	COG2814	Major facilitator Superfamily
K5L00_08620	COG0732	type I restriction modification DNA specificity domain
K5L00_08635	COG1104	cysteine desulfurase activity
K5L00_08640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5L00_08645	COG0656	L-ascorbic acid biosynthetic process
K5L00_08665	COG1129	ABC transporter
K5L00_08680	COG0737	Belongs to the 5'-nucleotidase family
K5L00_08705	COG0583	DNA-binding transcription factor activity
K5L00_08715	COG1979	alcohol dehydrogenase
K5L00_08725	COG2610	gluconate transmembrane transporter activity
K5L00_08730	COG1012	belongs to the aldehyde dehydrogenase family
K5L00_08740	COG3829	transcription factor binding
K5L00_08740	COG3290	protein histidine kinase activity
K5L00_08745	COG0514	ATP-dependent DNA helicase (RecQ)
K5L00_08750	COG2860	membrane
K5L00_08765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5L00_08775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5L00_08780	COG0583	DNA-binding transcription factor activity
K5L00_08790	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5L00_08795	COG0022	dehydrogenase e1 component
K5L00_08800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5L00_08805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5L00_08810	COG3426	butyrate kinase activity
K5L00_08815	COG0280	phosphate acetyltransferase
K5L00_08820	COG0386	Belongs to the glutathione peroxidase family
K5L00_08825	COG4807	Protein conserved in bacteria
K5L00_08830	COG1671	Belongs to the UPF0178 family
K5L00_08835	COG2223	nitrite transmembrane transporter activity
K5L00_08860	COG0673	inositol 2-dehydrogenase activity
K5L00_08865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5L00_08865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5L00_08890	COG0673	inositol 2-dehydrogenase activity
K5L00_08905	COG0395	ABC-type sugar transport system, permease component
K5L00_08910	COG1175	transmembrane transport
K5L00_08915	COG2182	Extracellular solute-binding protein
K5L00_08920	COG0673	inositol 2-dehydrogenase activity
K5L00_08955	COG3493	citrate carrier protein
K5L00_08960	COG3290	protein histidine kinase activity
K5L00_08965	COG4565	transcriptional regulatory protein
K5L00_09035	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5L00_09045	COG4869	propanediol catabolic process
K5L00_09050	COG1012	belongs to the aldehyde dehydrogenase family
K5L00_09050	COG1454	alcohol dehydrogenase
K5L00_09100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5L00_09105	COG1882	Formate acetyltransferase
K5L00_09120	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K5L00_09140	COG0789	Transcriptional regulator
K5L00_09140	COG4978	Transcriptional regulator
K5L00_09150	COG1609	Transcriptional regulator
K5L00_09150	COG2207	Transcriptional regulator
K5L00_09155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5L00_09205	COG0719	Fe-S assembly protein
K5L00_09215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5L00_09220	COG0719	Fe-S assembly protein
K5L00_09230	COG1464	Belongs to the NlpA lipoprotein family
K5L00_09235	COG2011	ABC-type metal ion transport system permease component
K5L00_09240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5L00_09250	COG1937	Protein conserved in bacteria
K5L00_09255	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5L00_09260	COG0488	(ABC) transporter
K5L00_09275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5L00_09280	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K5L00_09290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5L00_09295	COG0517	IMP dehydrogenase activity
K5L00_09300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5L00_09300	COG0574	Belongs to the PEP-utilizing enzyme family
K5L00_09310	COG1131	(ABC) transporter
K5L00_09330	COG0488	(ABC) transporter
K5L00_09335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5L00_09340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5L00_09355	COG1476	TRANSCRIPTIONal
K5L00_09360	COG1368	sulfuric ester hydrolase activity
K5L00_09365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5L00_09370	COG1660	Displays ATPase and GTPase activities
K5L00_09375	COG0254	rRNA binding
K5L00_09380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5L00_09385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5L00_09395	COG1012	belongs to the aldehyde dehydrogenase family
K5L00_09405	COG3343	RNA polymerase activity
K5L00_09415	COG0095	Lipoate-protein ligase
K5L00_09420	COG1078	dGTPase activity
K5L00_09425	COG0561	phosphatase activity
K5L00_09430	COG2962	Rard protein
K5L00_09435	COG0516	GMP reductase activity
K5L00_09445	COG1131	(ABC) transporter
K5L00_09450	COG4989	oxidoreductase activity
K5L00_09460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5L00_09465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5L00_09470	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5L00_09470	COG3942	CHAP domain
K5L00_09495	COG4467	Involved in initiation control of chromosome replication
K5L00_09500	COG1774	PSP1 C-terminal conserved region
K5L00_09505	COG0470	DNA polymerase III
K5L00_09510	COG3870	Protein conserved in bacteria
K5L00_09515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5L00_09520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5L00_09525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5L00_09530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5L00_09535	COG1073	alpha beta
K5L00_09545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5L00_09550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5L00_09555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5L00_09565	COG1950	PFAM Membrane protein of
K5L00_09580	COG0739	heme binding
K5L00_09580	COG0741	lytic transglycosylase activity
K5L00_09580	COG1196	nuclear chromosome segregation
K5L00_09585	COG0704	Plays a role in the regulation of phosphate uptake
K5L00_09590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5L00_09595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5L00_09600	COG0581	inorganic phosphate transmembrane transporter activity
K5L00_09605	COG0573	inorganic phosphate transmembrane transporter activity
K5L00_09620	COG2177	Part of the ABC transporter FtsEX involved in
K5L00_09625	COG2884	Cell division ATP-binding protein ftsE
K5L00_09635	COG0653	protein targeting
K5L00_09645	COG1040	competence protein
K5L00_09650	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K5L00_09655	COG2267	carboxylic ester hydrolase activity
K5L00_09665	COG1739	Uncharacterized protein family UPF0029
K5L00_09670	COG2188	Transcriptional regulator
K5L00_09680	COG1309	transcriptional regulator
K5L00_09715	COG0517	IMP dehydrogenase activity
K5L00_09725	COG0411	ABC transporter
K5L00_09735	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5L00_09745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5L00_09755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5L00_09765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5L00_09770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5L00_09775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5L00_09780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5L00_09785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5L00_09790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5L00_09795	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5L00_09800	COG0356	it plays a direct role in the translocation of protons across the membrane
K5L00_09805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5L00_09810	COG0557	exoribonuclease II activity
K5L00_09825	COG3397	chitin binding
K5L00_09830	COG1942	4-Oxalocrotonate Tautomerase
K5L00_09875	COG2378	regulation of single-species biofilm formation
K5L00_09890	COG0716	FMN binding
K5L00_09910	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K5L00_09920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5L00_09940	COG0590	tRNA wobble adenosine to inosine editing
K5L00_09945	COG1953	Uracil, thiamine, allantoin
K5L00_09955	COG2508	Transcriptional regulator
K5L00_09965	COG1132	(ABC) transporter
K5L00_09970	COG4988	ABC transporter
K5L00_09980	COG1288	antiporter activity
K5L00_09985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5L00_09995	COG1609	Transcriptional regulator
K5L00_10015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5L00_10020	COG0732	type I restriction modification DNA specificity domain
K5L00_10025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5L00_10035	COG4974	Belongs to the 'phage' integrase family
K5L00_10045	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5L00_10050	COG0149	triose-phosphate isomerase activity
K5L00_10055	COG0126	phosphoglycerate kinase activity
K5L00_10065	COG2390	Transcriptional regulator
K5L00_10070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5L00_10080	COG0740	serine-type endopeptidase activity
K5L00_10105	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5L00_10110	COG0022	dehydrogenase e1 component
K5L00_10115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5L00_10120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5L00_10125	COG3284	Transcriptional regulator
K5L00_10130	COG1481	regulation of sporulation
K5L00_10140	COG1660	Displays ATPase and GTPase activities
K5L00_10145	COG2186	Transcriptional regulator
K5L00_10150	COG1131	(ABC) transporter
K5L00_10165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5L00_10170	COG0556	nucleotide-excision repair
K5L00_10175	COG3579	cysteine-type endopeptidase activity
K5L00_10180	COG1316	TRANSCRIPTIONal
K5L00_10185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5L00_10195	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5L00_10200	COG2304	oxidoreductase activity
K5L00_10210	COG0714	Associated with various cellular activities
K5L00_10215	COG4716	Myosin-crossreactive antigen
K5L00_10230	COG2608	mercury ion transmembrane transporter activity
K5L00_10235	COG2723	6-phospho-beta-galactosidase activity
K5L00_10240	COG2190	(PTS) system
K5L00_10240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_10240	COG1263	PTS System
K5L00_10245	COG3711	transcriptional antiterminator
K5L00_10255	COG0436	Aminotransferase
K5L00_10265	COG1199	ATP-dependent helicase activity
K5L00_10265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5L00_10275	COG2246	polysaccharide biosynthetic process
K5L00_10325	COG1098	S1 RNA binding domain
K5L00_10330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5L00_10335	COG0572	uridine kinase
K5L00_10340	COG4619	ABC transporter
K5L00_10345	COG0390	transport system, permease component
K5L00_10355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5L00_10360	COG2188	Transcriptional regulator
K5L00_10365	COG1446	asparaginase
K5L00_10385	COG4608	Belongs to the ABC transporter superfamily
K5L00_10390	COG0444	Belongs to the ABC transporter superfamily
K5L00_10395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5L00_10400	COG0601	transmembrane transport
K5L00_10410	COG4166	transmembrane transport
K5L00_10420	COG3716	PTS system mannose fructose sorbose family IID component
K5L00_10425	COG3715	PTS system
K5L00_10435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5L00_10435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_10440	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5L00_10440	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5L00_10455	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5L00_10460	COG4166	transmembrane transport
K5L00_10465	COG4166	transmembrane transport
K5L00_10470	COG4166	transmembrane transport
K5L00_10480	COG4948	Mandelate Racemase Muconate Lactonizing
K5L00_10495	COG2723	6-phospho-beta-galactosidase activity
K5L00_10500	COG0371	Dehydrogenase
K5L00_10505	COG0765	amino acid transport
K5L00_10510	COG1126	abc transporter atp-binding protein
K5L00_10515	COG0436	Aminotransferase
K5L00_10525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K5L00_10530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5L00_10540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K5L00_10545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5L00_10550	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5L00_10550	COG3942	CHAP domain
K5L00_10560	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5L00_10565	COG2514	catechol 2,3-dioxygenase activity
K5L00_10580	COG2217	Heavy metal translocating P-type atpase
K5L00_10590	COG5002	protein histidine kinase activity
K5L00_10595	COG0745	RESPONSE REGULATOR receiver
K5L00_10600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5L00_10605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5L00_10610	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5L00_10620	COG4703	Protein of unknown function (DUF1797)
K5L00_10625	COG2084	Dehydrogenase
K5L00_10635	COG0438	transferase activity, transferring glycosyl groups
K5L00_10640	COG0438	transferase activity, transferring glycosyl groups
K5L00_10645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5L00_10660	COG0542	response to heat
K5L00_10675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5L00_10685	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5L00_10705	COG0463	Glycosyl transferase, family 2
K5L00_10730	COG1253	flavin adenine dinucleotide binding
K5L00_10735	COG0628	permease
K5L00_10740	COG2153	protein acetylation
K5L00_10750	COG3557	Belongs to the UPF0374 family
K5L00_10755	COG1194	a g-specific adenine glycosylase
K5L00_10760	COG2137	regulation of response to DNA damage stimulus
K5L00_10765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5L00_10770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5L00_10800	COG0589	response to stress
K5L00_10805	COG1316	TRANSCRIPTIONal
K5L00_10820	COG3955	Domain of unknown function (DUF1919)
K5L00_10825	COG5039	Polysaccharide pyruvyl transferase
K5L00_10830	COG1216	Glycosyl transferase, family 2
K5L00_10830	COG1442	glycosyl transferase family 8
K5L00_10855	COG1086	Polysaccharide biosynthesis protein
K5L00_10865	COG1215	transferase activity, transferring glycosyl groups
K5L00_10875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5L00_10885	COG4464	protein tyrosine phosphatase activity
K5L00_10890	COG0489	protein tyrosine kinase activity
K5L00_10900	COG4372	Transposase
K5L00_10920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5L00_10925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5L00_10930	COG1682	transport, permease protein
K5L00_10935	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K5L00_10940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5L00_10945	COG1134	teichoic acid transport
K5L00_10950	COG1316	TRANSCRIPTIONal
K5L00_10955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5L00_10965	COG1295	ribonuclease BN
K5L00_10970	COG0024	Methionine aminopeptidase
K5L00_10975	COG0716	FMN binding
K5L00_10985	COG2309	aminopeptidase activity
K5L00_10990	COG0726	polysaccharide deacetylase
K5L00_11000	COG3850	Histidine kinase
K5L00_11000	COG5002	protein histidine kinase activity
K5L00_11005	COG0745	RESPONSE REGULATOR receiver
K5L00_11015	COG1316	TRANSCRIPTIONal
K5L00_11280	COG0582	viral genome integration into host DNA
K5L00_11320	COG1396	sequence-specific DNA binding
K5L00_11350	COG1447	Phosphotransferase system cellobiose-specific component IIA
K5L00_11355	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_11375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_11385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5L00_11385	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5L00_11390	COG0513	Belongs to the DEAD box helicase family
K5L00_11400	COG2890	protein-(glutamine-N5) methyltransferase activity
K5L00_11415	COG1132	(ABC) transporter
K5L00_11430	COG2388	GCN5-related N-acetyl-transferase
K5L00_11435	COG5503	Protein of unknown function (DUF1447)
K5L00_11445	COG1278	Cold shock
K5L00_11450	COG2003	Belongs to the UPF0758 family
K5L00_11455	COG0546	phosphoglycolate phosphatase activity
K5L00_11460	COG0285	dihydrofolate synthase activity
K5L00_11465	COG0525	valine-tRNA ligase activity
K5L00_11475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5L00_11480	COG0301	tRNA thio-modification
K5L00_11485	COG1104	cysteine desulfurase activity
K5L00_11490	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K5L00_11495	COG0527	aspartate kinase activity
K5L00_11510	COG0561	phosphatase activity
K5L00_11525	COG3594	Acyltransferase
K5L00_11545	COG3091	SprT-like family
K5L00_11550	COG2183	response to ionizing radiation
K5L00_11560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5L00_11575	COG0681	Belongs to the peptidase S26 family
K5L00_11585	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5L00_11590	COG1876	peptidase activity
K5L00_11600	COG4129	membrane
K5L00_11615	COG0384	phenazine biosynthesis protein PhzF
K5L00_11625	COG0789	Transcriptional regulator
K5L00_11640	COG2268	Band 7 protein
K5L00_11700	COG0436	Aminotransferase
K5L00_11710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5L00_11725	COG1174	glycine betaine transport
K5L00_11735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5L00_11740	COG3599	regulation of cell shape
K5L00_11745	COG2302	S4 RNA-binding domain
K5L00_11755	COG1799	cell septum assembly
K5L00_11760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5L00_11765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5L00_11770	COG0849	cell division
K5L00_11775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5L00_11780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5L00_11785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5L00_11790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5L00_11795	COG0768	penicillin binding
K5L00_11805	COG0275	rRNA processing
K5L00_11810	COG2001	Belongs to the MraZ family
K5L00_11825	COG0497	DNA recombination
K5L00_11830	COG1438	arginine binding
K5L00_11835	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K5L00_11845	COG1722	exodeoxyribonuclease VII activity
K5L00_11850	COG1570	exodeoxyribonuclease VII activity
K5L00_11855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5L00_11860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5L00_11865	COG1302	Protein conserved in bacteria
K5L00_11870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5L00_11875	COG0006	proline dipeptidase activity
K5L00_11880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5L00_11885	COG2868	ribosomal protein
K5L00_11890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5L00_11905	COG4122	O-methyltransferase activity
K5L00_11910	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K5L00_11915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K5L00_11920	COG0222	ribosome binding
K5L00_11925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5L00_11930	COG0081	regulation of translation
K5L00_11935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5L00_11950	COG2217	Heavy metal translocating P-type atpase
K5L00_11955	COG0673	inositol 2-dehydrogenase activity
K5L00_11975	COG0673	inositol 2-dehydrogenase activity
K5L00_11985	COG1418	mRNA catabolic process
K5L00_11990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5L00_11995	COG1058	Belongs to the CinA family
K5L00_11995	COG1546	Belongs to the CinA family
K5L00_12000	COG1760	l-serine dehydratase
K5L00_12005	COG1760	l-serine dehydratase
K5L00_12020	COG1757	Na H antiporter
K5L00_12030	COG0250	Participates in transcription elongation, termination and antitermination
K5L00_12040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5L00_12055	COG0456	acetyltransferase
K5L00_12060	COG0431	NADPH-dependent FMN reductase
K5L00_12065	COG1597	lipid kinase activity
K5L00_12080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5L00_12085	COG0406	alpha-ribazole phosphatase activity
K5L00_12090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5L00_12095	COG0500	methyltransferase
K5L00_12100	COG3142	Participates in the control of copper homeostasis
K5L00_12120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5L00_12125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5L00_12130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5L00_12135	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5L00_12135	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5L00_12140	COG0626	cystathionine gamma-synthase activity
K5L00_12145	COG0251	oxidation-reduction process
K5L00_12150	COG0842	Transport permease protein
K5L00_12155	COG1131	(ABC) transporter
K5L00_12165	COG0456	acetyltransferase
K5L00_12170	COG2239	Acts as a magnesium transporter
K5L00_12175	COG0564	pseudouridine synthase activity
K5L00_12180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5L00_12185	COG2357	RelA SpoT domain protein
K5L00_12190	COG4116	CYTH
K5L00_12195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5L00_12200	COG1164	Oligoendopeptidase f
K5L00_12210	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5L00_12215	COG0488	(ABC) transporter
K5L00_12220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5L00_12235	COG0459	protein refolding
K5L00_12245	COG0783	Belongs to the Dps family
K5L00_12250	COG0693	protein deglycase activity
K5L00_12275	COG1454	alcohol dehydrogenase
K5L00_12275	COG1012	belongs to the aldehyde dehydrogenase family
K5L00_12280	COG2610	gluconate transmembrane transporter activity
K5L00_12285	COG1028	Short-chain dehydrogenase reductase Sdr
K5L00_12290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5L00_12295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K5L00_12305	COG0583	DNA-binding transcription factor activity
K5L00_12310	COG2030	dehydratase
K5L00_12315	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5L00_12320	COG4670	ketone body catabolic process
K5L00_12325	COG0583	DNA-binding transcription factor activity
K5L00_12345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5L00_12350	COG4109	DRTGG domain
K5L00_12355	COG2814	Major facilitator Superfamily
K5L00_12365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5L00_12370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5L00_12375	COG4720	Psort location CytoplasmicMembrane, score
K5L00_12380	COG1132	(ABC) transporter
K5L00_12385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5L00_12390	COG0419	ATPase involved in DNA repair
K5L00_12395	COG0420	3'-5' exonuclease activity
K5L00_12400	COG1309	transcriptional regulator
K5L00_12410	COG1131	(ABC) transporter
K5L00_12415	COG0204	Acyl-transferase
K5L00_12420	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5L00_12425	COG2827	Endonuclease containing a URI domain
K5L00_12430	COG2226	methyltransferase
K5L00_12435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5L00_12440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5L00_12445	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5L00_12455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5L00_12475	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5L00_12485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5L00_12490	COG0640	Transcriptional regulator
K5L00_12500	COG3878	Protein conserved in bacteria
K5L00_12510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5L00_12515	COG2264	protein methyltransferase activity
K5L00_12525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5L00_12545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5L00_12550	COG0827	DNA restriction-modification system
K5L00_12580	COG4537	Required for transformation and DNA binding
K5L00_12590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5L00_12600	COG0217	transcriptional regulatory protein
K5L00_12630	COG1792	Involved in formation and maintenance of cell shape
K5L00_12635	COG1454	alcohol dehydrogenase
K5L00_12635	COG1012	belongs to the aldehyde dehydrogenase family
K5L00_12650	COG0343	queuine tRNA-ribosyltransferase activity
K5L00_12655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5L00_12660	COG2255	four-way junction helicase activity
K5L00_12675	COG0424	maF-like protein
K5L00_12680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5L00_12685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5L00_12695	COG1692	metallophosphoesterase
K5L00_12710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5L00_12715	COG4684	Psort location CytoplasmicMembrane, score
K5L00_12735	COG3859	Proton-coupled thiamine transporter YuaJ
K5L00_12745	COG1309	transcriptional regulator
K5L00_12760	COG1388	LysM domain
K5L00_12760	COG3584	3D domain protein
K5L00_12770	COG1132	(ABC) transporter
K5L00_12775	COG1132	(ABC) transporter
K5L00_12795	COG1011	Hydrolase
K5L00_12800	COG0789	Transcriptional regulator
K5L00_12815	COG1803	Methylglyoxal synthase
K5L00_12820	COG3842	ATPase activity
K5L00_12835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5L00_12840	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K5L00_12845	COG0084	hydrolase, TatD family'
K5L00_12850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5L00_12850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5L00_12860	COG1914	H( )-stimulated, divalent metal cation uptake system
K5L00_12870	COG2207	Transcriptional regulator
K5L00_12870	COG3708	Transcriptional regulator
K5L00_12875	COG0456	acetyltransferase
K5L00_12880	COG1418	mRNA catabolic process
K5L00_12885	COG0366	Alpha amylase catalytic
K5L00_12890	COG1263	PTS System
K5L00_12890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_12895	COG2188	Transcriptional regulator
K5L00_12900	COG0415	Belongs to the DNA photolyase family
K5L00_12905	COG1737	Transcriptional regulator
K5L00_12925	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K5L00_12930	COG2723	6-phospho-beta-galactosidase activity
K5L00_12940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_12950	COG1053	succinate dehydrogenase
K5L00_12950	COG3976	FMN-binding domain protein
K5L00_12955	COG4607	ABC-type enterochelin transport system periplasmic component
K5L00_12960	COG4604	ABC transporter, ATP-binding protein
K5L00_12965	COG4605	iron ion homeostasis
K5L00_12970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5L00_12975	COG5506	Protein of unknown function (DUF1694)
K5L00_12980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5L00_13020	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5L00_13020	COG2918	glutathione biosynthetic process
K5L00_13025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5L00_13025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5L00_13025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5L00_13030	COG1105	Belongs to the carbohydrate kinase PfkB family
K5L00_13035	COG1349	DNA-binding transcription factor activity
K5L00_13040	COG0552	protein localization to endoplasmic reticulum
K5L00_13045	COG0561	phosphatase activity
K5L00_13050	COG1196	nuclear chromosome segregation
K5L00_13055	COG0571	ribonuclease III activity
K5L00_13060	COG0747	negative chemotaxis
K5L00_13065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5L00_13070	COG0601	transmembrane transport
K5L00_13085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5L00_13090	COG0416	fatty acid biosynthetic process
K5L00_13095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5L00_13110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5L00_13115	COG1564	THIamine pyrophosphokinase
K5L00_13120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5L00_13125	COG1162	GTPase activity
K5L00_13130	COG0515	serine threonine protein kinase
K5L00_13130	COG2815	serine threonine protein kinase
K5L00_13140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5L00_13140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5L00_13145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5L00_13150	COG0242	peptide deformylase activity
K5L00_13155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5L00_13170	COG0384	phenazine biosynthesis protein PhzF
K5L00_13180	COG0194	GDP metabolic process
K5L00_13185	COG1561	YicC-like family, N-terminal region
K5L00_13205	COG0736	holo-[acyl-carrier-protein] synthase activity
K5L00_13215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5L00_13220	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5L00_13230	COG3764	Sortase (surface protein transpeptidase)
K5L00_13235	COG3481	metal-dependent phosphohydrolase, HD sub domain
K5L00_13240	COG4717	serine-type aminopeptidase activity
K5L00_13250	COG3679	Belongs to the UPF0342 family
K5L00_13255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5L00_13260	COG0564	pseudouridine synthase activity
K5L00_13285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5L00_13300	COG1438	arginine binding
K5L00_13305	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5L00_13315	COG2207	Transcriptional regulator
K5L00_13320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5L00_13340	COG2814	Major facilitator Superfamily
K5L00_13350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5L00_13365	COG0456	acetyltransferase
K5L00_13365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K5L00_13375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5L00_13400	COG3279	Response regulator of the LytR AlgR family
K5L00_13410	COG4166	transmembrane transport
K5L00_13420	COG1247	-acetyltransferase
K5L00_13430	COG0110	maltose O-acetyltransferase activity
K5L00_13440	COG0427	acetyl-CoA hydrolase
K5L00_13445	COG1024	Enoyl-CoA hydratase
K5L00_13450	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5L00_13455	COG0183	Belongs to the thiolase family
K5L00_13460	COG0583	DNA-binding transcription factor activity
K5L00_13465	COG1960	acyl-CoA dehydrogenase activity
K5L00_13480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5L00_13485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5L00_13495	COG2323	membrane
K5L00_13505	COG2723	6-phospho-beta-galactosidase activity
K5L00_13510	COG1737	Transcriptional regulator
K5L00_13520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5L00_13525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5L00_13580	COG0400	carboxylic ester hydrolase activity
K5L00_13585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5L00_13590	COG0346	lactoylglutathione lyase activity
K5L00_13595	COG0346	lactoylglutathione lyase activity
K5L00_13600	COG1846	Transcriptional regulator
K5L00_13630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5L00_13635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K5L00_13640	COG1024	Enoyl-CoA hydratase
K5L00_13645	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5L00_13650	COG0183	Belongs to the thiolase family
K5L00_13655	COG0583	DNA-binding transcription factor activity
K5L00_13665	COG0346	lactoylglutathione lyase activity
K5L00_13670	COG2190	(PTS) system
K5L00_13670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_13670	COG1263	PTS System
K5L00_13675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5L00_13680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5L00_13685	COG1486	melibiose metabolic process
K5L00_13690	COG1263	PTS System
K5L00_13690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5L00_13705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5L00_13720	COG1304	FMN binding
K5L00_13725	COG1346	cytolysis
K5L00_13730	COG1380	Effector of murein hydrolase LrgA
K5L00_13745	COG1054	Belongs to the UPF0176 family
K5L00_13755	COG0604	alcohol dehydrogenase
K5L00_13765	COG0656	L-ascorbic acid biosynthetic process
K5L00_13770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5L00_13795	COG0494	nUDIX hydrolase
K5L00_13810	COG0475	glutathione-regulated potassium exporter activity
K5L00_13845	COG3759	membrane
K5L00_13850	COG0778	Nitroreductase
K5L00_13855	COG1846	Transcriptional regulator
K5L00_13865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5L00_13870	COG3959	Transketolase, thiamine diphosphate binding domain
K5L00_13885	COG3711	transcriptional antiterminator
K5L00_13890	COG1011	Hydrolase
K5L00_13895	COG0402	S-adenosylhomocysteine deaminase activity
K5L00_13900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5L00_13925	COG1309	transcriptional regulator
K5L00_13935	COG0346	lactoylglutathione lyase activity
K5L00_13960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5L00_13965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5L00_13980	COG1122	ATPase activity
K5L00_13985	COG1122	ATPase activity
K5L00_13990	COG0203	ribosomal protein L17
K5L00_13995	COG0202	RNA polymerase activity
K5L00_14000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5L00_14005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5L00_14010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5L00_14015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5L00_14020	COG0563	adenylate kinase activity
K5L00_14030	COG0200	Binds to the 23S rRNA
K5L00_14035	COG1841	ribosomal large subunit assembly
K5L00_14040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5L00_14050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5L00_14055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5L00_14060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5L00_14065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5L00_14070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5L00_14075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5L00_14080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5L00_14085	COG0255	Belongs to the universal ribosomal protein uL29 family
K5L00_14090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5L00_14095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5L00_14100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5L00_14105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5L00_14110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5L00_14115	COG0089	rRNA binding
K5L00_14120	COG0088	Forms part of the polypeptide exit tunnel
K5L00_14125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5L00_14130	COG0051	transcription antitermination factor activity, RNA binding
K5L00_14140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5L00_14145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5L00_14150	COG0049	tRNA binding
K5L00_14155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5L00_14160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5L00_14165	COG0588	phosphoglycerate mutase activity
K5L00_14175	COG1114	Component of the transport system for branched-chain amino acids
K5L00_14420	COG4373	Mu-like prophage FluMu protein gp28
K5L00_14470	COG0210	DNA helicase
K5L00_14615	COG0492	ferredoxin-NADP+ reductase activity
K5L00_14620	COG2337	Toxic component of a toxin-antitoxin (TA) module
K5L00_14800	COG0328	RNA-DNA hybrid ribonuclease activity
K5L00_14810	COG2176	DNA-directed DNA polymerase activity
K5L00_14920	COG0587	DNA-directed DNA polymerase activity
K5L00_15005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5L00_15065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5L00_15070	COG1780	Probably involved in ribonucleotide reductase function
K5L00_15075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5L00_15080	COG1328	CTP reductase activity
K5L00_15110	COG0582	viral genome integration into host DNA