locus-tag	class	description
K5K97_00010	COG0840	transmembrane signaling receptor activity
K5K97_00015	COG2884	Cell division ATP-binding protein ftsE
K5K97_00025	COG4786	Flagellar basal body rod
K5K97_00030	COG1191	sigma factor activity
K5K97_00035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K5K97_00040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K5K97_00045	COG1684	flagellar biosynthetic protein fliR
K5K97_00055	COG1338	Plays a role in the flagellum-specific transport system
K5K97_00065	COG1580	Controls the rotational direction of flagella during chemotaxis
K5K97_00075	COG4786	Flagellar basal body rod
K5K97_00095	COG1157	protein secretion by the type III secretion system
K5K97_00105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5K97_00115	COG1677	Flagellar hook-basal body complex protein FliE
K5K97_00125	COG1815	bacterial-type flagellum-dependent cell motility
K5K97_00130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5K97_00135	COG1360	Flagellar Motor Protein
K5K97_00145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K97_00155	COG1227	inorganic diphosphatase activity
K5K97_00160	COG2076	Multidrug Resistance protein
K5K97_00165	COG2076	Multidrug Resistance protein
K5K97_00180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5K97_00185	COG1882	Formate acetyltransferase
K5K97_00190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5K97_00195	COG0187	DNA topoisomerase II activity
K5K97_00210	COG0737	Belongs to the 5'-nucleotidase family
K5K97_00235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K97_00240	COG1126	abc transporter atp-binding protein
K5K97_00245	COG0765	amino acid transport
K5K97_00265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5K97_00270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K97_00280	COG1484	DNA-dependent DNA replication
K5K97_00290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5K97_00295	COG0237	dephospho-CoA kinase activity
K5K97_00300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5K97_00305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K97_00305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K97_00310	COG0670	Belongs to the BI1 family
K5K97_00320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5K97_00350	COG0166	Belongs to the GPI family
K5K97_00355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5K97_00360	COG2081	HI0933 family
K5K97_00365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5K97_00370	COG0710	3-dehydroquinate dehydratase activity
K5K97_00375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5K97_00380	COG1368	sulfuric ester hydrolase activity
K5K97_00395	COG2030	dehydratase
K5K97_00400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5K97_00405	COG1597	lipid kinase activity
K5K97_00410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K97_00415	COG0154	amidase activity
K5K97_00420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K97_00425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5K97_00430	COG0210	DNA helicase
K5K97_00465	COG1217	gtp-binding protein TYPA
K5K97_00470	COG0483	inositol monophosphate 1-phosphatase activity
K5K97_00475	COG4476	Belongs to the UPF0223 family
K5K97_00480	COG3850	Histidine kinase
K5K97_00480	COG5002	protein histidine kinase activity
K5K97_00485	COG0745	RESPONSE REGULATOR receiver
K5K97_00540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K97_00545	COG1073	alpha beta
K5K97_00630	COG2151	metal-sulfur cluster biosynthetic enzyme
K5K97_00640	COG0825	malonyl-CoA metabolic process
K5K97_00645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5K97_00650	COG0439	Biotin carboxylase
K5K97_00655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5K97_00665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5K97_00675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5K97_00685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K97_00690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5K97_00700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K97_00705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5K97_00710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5K97_00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K97_00715	COG0072	phenylalanine-tRNA ligase activity
K5K97_00720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5K97_00725	COG1733	regulation of RNA biosynthetic process
K5K97_00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K97_00740	COG1254	Belongs to the acylphosphatase family
K5K97_00755	COG0083	homoserine kinase activity
K5K97_00765	COG0640	Transcriptional regulator
K5K97_00770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K97_00780	COG0534	Mate efflux family protein
K5K97_00785	COG0772	Belongs to the SEDS family
K5K97_00795	COG3833	ABC-type maltose transport systems, permease component
K5K97_00800	COG1175	transmembrane transport
K5K97_00805	COG2182	Extracellular solute-binding protein
K5K97_00815	COG0366	Alpha amylase catalytic
K5K97_00820	COG1609	Transcriptional regulator
K5K97_00830	COG1132	(ABC) transporter
K5K97_00835	COG1132	(ABC) transporter
K5K97_00840	COG3763	UPF0154 protein
K5K97_00845	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5K97_00850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K97_00855	COG1609	Transcriptional regulator
K5K97_00870	COG0668	transmembrane transport
K5K97_00875	COG1473	amidohydrolase
K5K97_00880	COG0517	IMP dehydrogenase activity
K5K97_00890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5K97_00900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5K97_00905	COG0456	acetyltransferase
K5K97_00915	COG1214	PFAM Peptidase M22, glycoprotease
K5K97_00920	COG0494	nUDIX hydrolase
K5K97_00925	COG1253	flavin adenine dinucleotide binding
K5K97_00930	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5K97_00935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K97_00945	COG0488	(ABC) transporter
K5K97_00960	COG4471	UPF0298 protein
K5K97_00975	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K5K97_00980	COG0772	Belongs to the SEDS family
K5K97_00985	COG4838	Belongs to the UPF0358 family
K5K97_00990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5K97_01000	COG4841	protein insertion into membrane
K5K97_01005	COG0569	domain protein
K5K97_01010	COG2197	response regulator
K5K97_01015	COG4585	Histidine kinase
K5K97_01025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5K97_01030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5K97_01035	COG2824	Alkylphosphonate utilization operon protein PhnA
K5K97_01050	COG2207	Transcriptional regulator
K5K97_01050	COG4753	response regulator
K5K97_01055	COG2972	Histidine kinase
K5K97_01065	COG1653	transport
K5K97_01070	COG0395	ABC-type sugar transport system, permease component
K5K97_01075	COG1175	transmembrane transport
K5K97_01080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K97_01085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K5K97_01085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5K97_01090	COG0726	polysaccharide deacetylase
K5K97_01095	COG0741	lytic transglycosylase activity
K5K97_01100	COG1116	anion transmembrane transporter activity
K5K97_01105	COG4521	taurine ABC transporter
K5K97_01110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K97_01115	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K97_01120	COG2391	methyltransferase activity
K5K97_01130	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K5K97_01135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K97_01140	COG1696	Membrane protein involved in D-alanine export
K5K97_01270	COG0735	belongs to the Fur family
K5K97_01275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5K97_01280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5K97_01285	COG1278	Cold shock
K5K97_01295	COG0328	RNA-DNA hybrid ribonuclease activity
K5K97_01300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5K97_01315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K97_01325	COG4608	Belongs to the ABC transporter superfamily
K5K97_01330	COG0444	Belongs to the ABC transporter superfamily
K5K97_01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K97_01340	COG0601	transmembrane transport
K5K97_01350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K97_01355	COG3442	glutamine amidotransferase
K5K97_01360	COG0686	Belongs to the AlaDH PNT family
K5K97_01365	COG1609	Transcriptional regulator
K5K97_01370	COG1482	cell wall glycoprotein biosynthetic process
K5K97_01380	COG0346	lactoylglutathione lyase activity
K5K97_01385	COG1132	(ABC) transporter
K5K97_01400	COG0492	ferredoxin-NADP+ reductase activity
K5K97_01405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5K97_01415	COG0647	UMP catabolic process
K5K97_01420	COG4470	Protein conserved in bacteria
K5K97_01425	COG0737	Belongs to the 5'-nucleotidase family
K5K97_01430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K97_01435	COG2365	Tyrosine phosphatase family
K5K97_01445	COG1131	(ABC) transporter
K5K97_01460	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K97_01480	COG3964	amidohydrolase
K5K97_01490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_01495	COG2188	Transcriptional regulator
K5K97_01500	COG3588	fructose-bisphosphate aldolase
K5K97_01505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K97_01510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5K97_01515	COG0116	Belongs to the methyltransferase superfamily
K5K97_01535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K97_01540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5K97_01555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5K97_01560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5K97_01565	COG0009	L-threonylcarbamoyladenylate synthase
K5K97_01570	COG2890	protein-(glutamine-N5) methyltransferase activity
K5K97_01575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5K97_01580	COG1435	thymidine kinase activity
K5K97_01585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5K97_01590	COG0628	permease
K5K97_01600	COG2706	6-phosphogluconolactonase activity
K5K97_01605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K97_01620	COG2855	membrane
K5K97_01625	COG1335	isochorismatase
K5K97_01630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K97_01645	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K5K97_01650	COG3853	Toxic anion resistance protein (TelA)
K5K97_01665	COG1074	ATP-dependent DNA helicase activity
K5K97_01670	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K5K97_01690	COG1396	sequence-specific DNA binding
K5K97_01695	COG2807	transmembrane transport
K5K97_01710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_01725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K97_01740	COG1363	Peptidase, m42
K5K97_01745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5K97_01750	COG3425	synthase
K5K97_01765	COG1136	(ABC) transporter
K5K97_01765	COG0577	efflux transmembrane transporter activity
K5K97_01770	COG0577	efflux transmembrane transporter activity
K5K97_01770	COG1136	(ABC) transporter
K5K97_01780	COG3328	transposase activity
K5K97_01785	COG0681	Belongs to the peptidase S26 family
K5K97_01795	COG1522	sequence-specific DNA binding
K5K97_01800	COG1335	isochorismatase
K5K97_01825	COG0504	CTP synthase activity
K5K97_01860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K97_01865	COG0351	phosphomethylpyrimidine kinase
K5K97_01870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K97_01875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5K97_01880	COG0427	acetyl-CoA hydrolase
K5K97_01885	COG1024	Enoyl-CoA hydratase
K5K97_01890	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K97_01895	COG1960	acyl-CoA dehydrogenase activity
K5K97_01900	COG0183	Belongs to the thiolase family
K5K97_01905	COG0583	DNA-binding transcription factor activity
K5K97_01910	COG1960	acyl-CoA dehydrogenase activity
K5K97_01915	COG0366	Alpha amylase catalytic
K5K97_01920	COG0395	ABC-type sugar transport system, permease component
K5K97_01925	COG1175	transmembrane transport
K5K97_01930	COG1653	transport
K5K97_01955	COG1428	Deoxynucleoside kinase
K5K97_01965	COG0590	tRNA wobble adenosine to inosine editing
K5K97_01970	COG2508	Transcriptional regulator
K5K97_01975	COG2738	Putative neutral zinc metallopeptidase
K5K97_01985	COG2199	diguanylate cyclase activity
K5K97_01995	COG0716	FMN binding
K5K97_02000	COG0509	glycine decarboxylation via glycine cleavage system
K5K97_02005	COG1393	Belongs to the ArsC family
K5K97_02020	COG0772	Belongs to the SEDS family
K5K97_02030	COG0300	oxidoreductase activity
K5K97_02045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K97_02050	COG1121	(ABC) transporter
K5K97_02055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5K97_02070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K97_02075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5K97_02080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5K97_02095	COG1304	FMN binding
K5K97_02100	COG3655	Transcriptional regulator
K5K97_02120	COG1323	Belongs to the UPF0348 family
K5K97_02125	COG2226	methyltransferase
K5K97_02130	COG0799	negative regulation of ribosome biogenesis
K5K97_02140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5K97_02145	COG1534	Rna-binding protein
K5K97_02150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K97_02165	COG0138	bifunctional purine biosynthesis protein purh
K5K97_02170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5K97_02175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5K97_02185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K97_02195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K97_02200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5K97_02210	COG4808	Protein conserved in bacteria
K5K97_02215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5K97_02220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K97_02225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5K97_02230	COG1070	Carbohydrate kinase
K5K97_02255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5K97_02260	COG1228	amidohydrolase
K5K97_02265	COG1597	lipid kinase activity
K5K97_02270	COG0456	acetyltransferase
K5K97_02275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K97_02280	COG0124	histidyl-tRNA synthetase
K5K97_02290	COG0531	amino acid
K5K97_02300	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K5K97_02305	COG3404	Formiminotransferase-cyclodeaminase
K5K97_02320	COG1609	Transcriptional regulator
K5K97_02325	COG1486	melibiose metabolic process
K5K97_02335	COG1464	Belongs to the NlpA lipoprotein family
K5K97_02340	COG2011	ABC-type metal ion transport system permease component
K5K97_02345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K97_02355	COG1268	BioY protein
K5K97_02365	COG0765	amino acid transport
K5K97_02370	COG0765	amino acid transport
K5K97_02375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K97_02380	COG1126	abc transporter atp-binding protein
K5K97_02390	COG4946	Tricorn protease homolog
K5K97_02390	COG1506	peptidase
K5K97_02390	COG0823	Involved in the tonB-independent uptake of proteins
K5K97_02400	COG0488	(ABC) transporter
K5K97_02405	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K5K97_02425	COG0367	asparagine synthase
K5K97_02435	COG0745	RESPONSE REGULATOR receiver
K5K97_02480	COG0246	Mannitol dehydrogenase
K5K97_02485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K97_02490	COG2213	PTS system mannitol-specific
K5K97_02495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K97_02500	COG3711	transcriptional antiterminator
K5K97_02505	COG2213	PTS system mannitol-specific
K5K97_02510	COG3711	transcriptional antiterminator
K5K97_02515	COG1263	PTS System
K5K97_02515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_02515	COG2190	(PTS) system
K5K97_02550	COG4975	Glucose uptake
K5K97_02555	COG1869	D-ribose catabolic process
K5K97_02565	COG1609	Transcriptional regulator
K5K97_02575	COG1305	Transglutaminase-like
K5K97_02600	COG1053	succinate dehydrogenase
K5K97_02600	COG3976	FMN-binding domain protein
K5K97_02600	COG0431	NADPH-dependent FMN reductase
K5K97_02620	COG0105	UTP biosynthetic process
K5K97_02625	COG0513	Belongs to the DEAD box helicase family
K5K97_02640	COG0159	tryptophan synthase activity
K5K97_02655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K97_02660	COG1695	Transcriptional regulator
K5K97_02670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K5K97_02675	COG3639	organic phosphonate transmembrane transporter activity
K5K97_02705	COG0662	Cupin 2, conserved barrel domain protein
K5K97_02710	COG0531	amino acid
K5K97_02715	COG0351	phosphomethylpyrimidine kinase
K5K97_02720	COG0352	thiamine-phosphate diphosphorylase activity
K5K97_02725	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K5K97_02735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5K97_02765	COG0022	dehydrogenase e1 component
K5K97_02770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K97_02795	COG3730	PTS system glucitol sorbitol-specific
K5K97_02800	COG3732	PTS system glucitol sorbitol-specific
K5K97_02810	COG1063	alcohol dehydrogenase
K5K97_02820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5K97_02825	COG0698	ribose 5-phosphate isomerase
K5K97_02835	COG3775	system Galactitol-specific IIC component
K5K97_02840	COG3414	Phosphotransferase system galactitol-specific IIB component
K5K97_02855	COG1349	DNA-binding transcription factor activity
K5K97_02860	COG0280	phosphate acetyltransferase
K5K97_02865	COG1012	belongs to the aldehyde dehydrogenase family
K5K97_02875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5K97_02885	COG1454	alcohol dehydrogenase
K5K97_02895	COG1288	antiporter activity
K5K97_02905	COG0698	ribose 5-phosphate isomerase
K5K97_02915	COG2169	Transcriptional regulator
K5K97_02935	COG0604	alcohol dehydrogenase
K5K97_02960	COG3732	PTS system glucitol sorbitol-specific
K5K97_02965	COG3730	PTS system glucitol sorbitol-specific
K5K97_02985	COG4684	Psort location CytoplasmicMembrane, score
K5K97_02990	COG0564	pseudouridine synthase activity
K5K97_03000	COG1175	transmembrane transport
K5K97_03005	COG0395	ABC-type sugar transport system, permease component
K5K97_03025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5K97_03055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5K97_03065	COG1132	(ABC) transporter
K5K97_03070	COG1132	(ABC) transporter
K5K97_03080	COG0217	transcriptional regulatory protein
K5K97_03085	COG1187	pseudouridine synthase activity
K5K97_03100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K5K97_03105	COG0745	RESPONSE REGULATOR receiver
K5K97_03120	COG1132	(ABC) transporter
K5K97_03130	COG2814	Major facilitator Superfamily
K5K97_03135	COG1846	Transcriptional regulator
K5K97_03140	COG0667	Aldo Keto reductase
K5K97_03145	COG0789	Transcriptional regulator
K5K97_03160	COG2723	6-phospho-beta-galactosidase activity
K5K97_03165	COG2188	Transcriptional regulator
K5K97_03170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_03175	COG1940	carbohydrate kinase activity
K5K97_03180	COG2723	6-phospho-beta-galactosidase activity
K5K97_03185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_03190	COG1737	Transcriptional regulator
K5K97_03200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K97_03210	COG0673	inositol 2-dehydrogenase activity
K5K97_03220	COG4166	transmembrane transport
K5K97_03225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K97_03230	COG1737	Transcriptional regulator
K5K97_03250	COG0395	ABC-type sugar transport system, permease component
K5K97_03255	COG1175	transmembrane transport
K5K97_03260	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5K97_03275	COG4166	transmembrane transport
K5K97_03280	COG4166	transmembrane transport
K5K97_03315	COG1573	uracil-dna glycosylase
K5K97_03335	COG1070	Carbohydrate kinase
K5K97_03340	COG1028	Short-chain dehydrogenase reductase Sdr
K5K97_03345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K5K97_03355	COG0277	FAD linked oxidase domain protein
K5K97_03365	COG2271	Major facilitator Superfamily
K5K97_03375	COG1174	glycine betaine transport
K5K97_03385	COG1174	glycine betaine transport
K5K97_03390	COG0542	response to heat
K5K97_03435	COG0556	nucleotide-excision repair
K5K97_03480	COG1401	restriction endodeoxyribonuclease activity
K5K97_03500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5K97_03505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5K97_03515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5K97_03530	COG5002	protein histidine kinase activity
K5K97_03535	COG0745	RESPONSE REGULATOR receiver
K5K97_03555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5K97_03560	COG1780	Probably involved in ribonucleotide reductase function
K5K97_03565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K97_03570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K97_03580	COG4862	establishment of competence for transformation
K5K97_03585	COG1393	Belongs to the ArsC family
K5K97_03590	COG0180	Tryptophanyl-tRNA synthetase
K5K97_03595	COG0740	serine-type endopeptidase activity
K5K97_03600	COG0095	Lipoate-protein ligase
K5K97_03605	COG1234	tRNA 3'-trailer cleavage
K5K97_03610	COG0577	efflux transmembrane transporter activity
K5K97_03625	COG1363	Peptidase, m42
K5K97_03630	COG0577	efflux transmembrane transporter activity
K5K97_03635	COG1136	(ABC) transporter
K5K97_03645	COG0642	Histidine kinase
K5K97_03680	COG2011	ABC-type metal ion transport system permease component
K5K97_03685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K97_03695	COG0028	Belongs to the TPP enzyme family
K5K97_03705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5K97_03710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5K97_03715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5K97_03740	COG2376	Dihydroxyacetone kinase
K5K97_03745	COG0371	Dehydrogenase
K5K97_03750	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K5K97_03755	COG1461	Dihydroxyacetone kinase
K5K97_03760	COG2376	Dihydroxyacetone kinase
K5K97_03765	COG1309	transcriptional regulator
K5K97_03785	COG1649	PFAM Uncharacterised BCR, COG1649
K5K97_03795	COG1940	carbohydrate kinase activity
K5K97_03805	COG1609	Transcriptional regulator
K5K97_03815	COG0383	alpha-mannosidase activity
K5K97_03825	COG3328	transposase activity
K5K97_03835	COG1185	polyribonucleotide nucleotidyltransferase activity
K5K97_03840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5K97_03845	COG0242	peptide deformylase activity
K5K97_03850	COG0561	phosphatase activity
K5K97_03855	COG2116	formate transmembrane transporter activity
K5K97_03860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5K97_03870	COG1668	transmembrane transport
K5K97_03875	COG4152	abc transporter atp-binding protein
K5K97_03900	COG0322	excinuclease ABC activity
K5K97_03905	COG3118	belongs to the thioredoxin family
K5K97_03910	COG1193	negative regulation of DNA recombination
K5K97_03925	COG3328	transposase activity
K5K97_03930	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K97_03935	COG3906	Belongs to the UPF0473 family
K5K97_03945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5K97_03950	COG4472	Bacterial protein of unknown function (DUF965)
K5K97_03955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K97_03965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K97_03970	COG1363	Peptidase, m42
K5K97_03980	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K97_03990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5K97_03995	COG0510	thiamine kinase activity
K5K97_04000	COG4473	ABC transporter
K5K97_04005	COG1131	(ABC) transporter
K5K97_04010	COG0537	adenosine 5'-monophosphoramidase activity
K5K97_04015	COG4980	gas vesicle protein
K5K97_04020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5K97_04035	COG1054	Belongs to the UPF0176 family
K5K97_04085	COG0363	glucosamine-6-phosphate deaminase activity
K5K97_04090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K97_04120	COG0798	PFAM Bile acid sodium symporter
K5K97_04175	COG1442	glycosyl transferase family 8
K5K97_04210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K97_04220	COG1609	Transcriptional regulator
K5K97_04235	COG0488	(ABC) transporter
K5K97_04245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5K97_04255	COG0628	permease
K5K97_04270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5K97_04275	COG1426	Protein conserved in bacteria
K5K97_04280	COG0300	oxidoreductase activity
K5K97_04285	COG0612	Peptidase, M16
K5K97_04290	COG0612	Peptidase, M16
K5K97_04295	COG1970	mechanosensitive ion channel activity
K5K97_04300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5K97_04310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K97_04315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K97_04320	COG1121	(ABC) transporter
K5K97_04325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5K97_04335	COG1177	transmembrane transport
K5K97_04340	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5K97_04345	COG3842	ATPase activity
K5K97_04355	COG0604	alcohol dehydrogenase
K5K97_04415	COG1473	amidohydrolase
K5K97_04420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5K97_04425	COG0038	chloride channel
K5K97_04435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K97_04440	COG4565	transcriptional regulatory protein
K5K97_04445	COG3290	protein histidine kinase activity
K5K97_04450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5K97_04455	COG0708	Exodeoxyribonuclease III
K5K97_04475	COG0802	atpase or kinase
K5K97_04485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K97_04495	COG1263	PTS System
K5K97_04495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_04495	COG2190	(PTS) system
K5K97_04505	COG1609	Transcriptional regulator
K5K97_04515	COG0280	phosphate acetyltransferase
K5K97_04525	COG0561	phosphatase activity
K5K97_04535	COG0025	NhaP-type Na H and K H
K5K97_04540	COG1278	Cold shock
K5K97_04560	COG0745	RESPONSE REGULATOR receiver
K5K97_04565	COG5002	protein histidine kinase activity
K5K97_04570	COG2433	Pfam Transposase IS66
K5K97_04595	COG1131	(ABC) transporter
K5K97_04635	COG1215	transferase activity, transferring glycosyl groups
K5K97_04645	COG2188	Transcriptional regulator
K5K97_04670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5K97_04695	COG2217	Heavy metal translocating P-type atpase
K5K97_04700	COG1285	pathogenesis
K5K97_04705	COG0251	oxidation-reduction process
K5K97_04725	COG2390	Transcriptional regulator
K5K97_04730	COG0583	DNA-binding transcription factor activity
K5K97_04735	COG4166	transmembrane transport
K5K97_04740	COG0402	S-adenosylhomocysteine deaminase activity
K5K97_04745	COG0402	S-adenosylhomocysteine deaminase activity
K5K97_04750	COG4335	DNA alkylation repair
K5K97_04775	COG3448	diguanylate cyclase activity
K5K97_04775	COG4175	Glycine betaine
K5K97_04830	COG1132	(ABC) transporter
K5K97_04835	COG1132	(ABC) transporter
K5K97_04840	COG0765	amino acid transport
K5K97_04845	COG1126	abc transporter atp-binding protein
K5K97_04850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K97_04860	COG0435	Glutathione S-transferase
K5K97_04870	COG3022	response to hydroperoxide
K5K97_04875	COG2252	PERMEase
K5K97_04895	COG5504	Zn-dependent protease
K5K97_04900	COG2723	6-phospho-beta-galactosidase activity
K5K97_04905	COG1940	carbohydrate kinase activity
K5K97_04915	COG3973	AAA domain
K5K97_04935	COG0531	amino acid
K5K97_04945	COG1757	Na H antiporter
K5K97_04965	COG4166	transmembrane transport
K5K97_04980	COG1136	(ABC) transporter
K5K97_04985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5K97_04985	COG0519	Catalyzes the synthesis of GMP from XMP
K5K97_04990	COG1072	(Pantothenic acid kinase))
K5K97_04995	COG2755	lipolytic protein G-D-S-L family
K5K97_05000	COG2813	Specifically methylates the guanine in position
K5K97_05005	COG0085	RNA polymerase activity
K5K97_05010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5K97_05025	COG3711	transcriptional antiterminator
K5K97_05030	COG2190	(PTS) system
K5K97_05030	COG1263	PTS System
K5K97_05030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_05035	COG2723	6-phospho-beta-galactosidase activity
K5K97_05055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5K97_05060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5K97_05070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5K97_05080	COG3158	transport of potassium into the cell
K5K97_05085	COG0756	dUTP diphosphatase activity
K5K97_05095	COG4956	integral membrane protein (PIN domain superfamily)
K5K97_05100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5K97_05105	COG1045	serine acetyltransferase
K5K97_05110	COG0215	cysteine-tRNA ligase activity
K5K97_05115	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K5K97_05120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K97_05125	COG3688	RNA-binding protein containing a PIN domain
K5K97_05135	COG4466	Protein conserved in bacteria
K5K97_05150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5K97_05155	COG4988	ABC transporter
K5K97_05160	COG1294	oxidase, subunit
K5K97_05165	COG1271	oxidase subunit
K5K97_05170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K97_05175	COG0826	peptidase U32
K5K97_05185	COG0542	response to heat
K5K97_05190	COG4463	regulation of RNA biosynthetic process
K5K97_05390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5K97_05395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K97_05400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5K97_05405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5K97_05410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5K97_05415	COG0037	tRNA processing
K5K97_05420	COG1098	S1 RNA binding domain
K5K97_05430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5K97_05435	COG2244	polysaccharide biosynthetic process
K5K97_05440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5K97_05445	COG0193	aminoacyl-tRNA hydrolase activity
K5K97_05450	COG0039	L-malate dehydrogenase activity
K5K97_05460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K97_05470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5K97_05525	COG3328	transposase activity
K5K97_05540	COG1733	regulation of RNA biosynthetic process
K5K97_05565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5K97_05570	COG3328	transposase activity
K5K97_05575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5K97_05585	COG1394	ATPase activity, coupled to movement of substances
K5K97_05590	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K5K97_05595	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5K97_05600	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
K5K97_05605	COG1527	subunit (C
K5K97_05615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K97_05620	COG1269	ATP hydrolysis coupled proton transport
K5K97_05630	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K97_05635	COG0659	secondary active sulfate transmembrane transporter activity
K5K97_05660	COG3328	transposase activity
K5K97_05670	COG1461	Dihydroxyacetone kinase
K5K97_05685	COG3328	transposase activity
K5K97_05700	COG1764	response to oxidative stress
K5K97_05705	COG0686	Belongs to the AlaDH PNT family
K5K97_05715	COG1278	Cold shock
K5K97_05725	COG1733	regulation of RNA biosynthetic process
K5K97_05760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K97_05775	COG1396	sequence-specific DNA binding
K5K97_05825	COG5294	Protein conserved in bacteria
K5K97_05845	COG3842	ATPase activity
K5K97_05850	COG0395	ABC-type sugar transport system, permease component
K5K97_05855	COG1175	transmembrane transport
K5K97_05860	COG1653	transport
K5K97_05870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5K97_05885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5K97_05895	COG0765	amino acid transport
K5K97_05900	COG1126	abc transporter atp-binding protein
K5K97_05920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K97_05925	COG1187	pseudouridine synthase activity
K5K97_05930	COG2244	polysaccharide biosynthetic process
K5K97_05935	COG0495	leucyl-tRNA aminoacylation
K5K97_05940	COG1388	LysM domain
K5K97_05940	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K97_05955	COG0671	phosphoesterase, PA-phosphatase related
K5K97_05960	COG1242	4 iron, 4 sulfur cluster binding
K5K97_05965	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K5K97_05970	COG1686	Belongs to the peptidase S11 family
K5K97_05985	COG0477	Major facilitator Superfamily
K5K97_05990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5K97_06010	COG0813	purine-nucleoside phosphorylase activity
K5K97_06020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5K97_06025	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5K97_06030	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5K97_06035	COG3845	ABC transporter
K5K97_06040	COG1744	ABC transporter substrate-binding protein PnrA-like
K5K97_06050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5K97_06055	COG1609	Transcriptional regulator
K5K97_06070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5K97_06090	COG4939	FMN-binding domain protein
K5K97_06105	COG0142	geranyltranstransferase activity
K5K97_06120	COG0488	(ABC) transporter
K5K97_06135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5K97_06140	COG0305	Participates in initiation and elongation during chromosome replication
K5K97_06145	COG0359	binds to the 23S rRNA
K5K97_06150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5K97_06155	COG0629	single-stranded DNA binding
K5K97_06160	COG0360	Binds together with S18 to 16S ribosomal RNA
K5K97_06170	COG0187	DNA topoisomerase II activity
K5K97_06175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5K97_06185	COG0592	DNA-directed DNA polymerase activity
K5K97_06190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5K97_06195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5K97_06200	COG0594	ribonuclease P activity
K5K97_06205	COG0706	membrane insertase activity
K5K97_06215	COG1438	arginine binding
K5K97_06220	COG2235	arginine
K5K97_06225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5K97_06230	COG0549	Belongs to the carbamate kinase family
K5K97_06240	COG1288	antiporter activity
K5K97_06245	COG0018	arginyl-trna synthetase
K5K97_06250	COG2153	protein acetylation
K5K97_06265	COG1438	arginine binding
K5K97_06275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5K97_06280	COG0445	tRNA wobble uridine modification
K5K97_06295	COG0357	Ribosomal RNA small subunit methyltransferase G
K5K97_06300	COG1192	Involved in chromosome partitioning
K5K97_06305	COG1475	DNA binding
K5K97_06310	COG4481	Protein conserved in bacteria
K5K97_06315	COG0012	GTP binding
K5K97_06325	COG0516	GMP reductase activity
K5K97_06325	COG0517	IMP dehydrogenase activity
K5K97_06335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5K97_06500	COG1114	Component of the transport system for branched-chain amino acids
K5K97_06505	COG0588	phosphoglycerate mutase activity
K5K97_06510	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5K97_06515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5K97_06520	COG0049	tRNA binding
K5K97_06525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5K97_06530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5K97_06540	COG0051	transcription antitermination factor activity, RNA binding
K5K97_06545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5K97_06550	COG0088	Forms part of the polypeptide exit tunnel
K5K97_06555	COG0089	rRNA binding
K5K97_06560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5K97_06565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5K97_06570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5K97_06575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5K97_06580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5K97_06585	COG0255	Belongs to the universal ribosomal protein uL29 family
K5K97_06590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5K97_06595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5K97_06600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5K97_06605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5K97_06610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K97_06615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5K97_06620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5K97_06630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5K97_06635	COG1841	ribosomal large subunit assembly
K5K97_06640	COG0200	Binds to the 23S rRNA
K5K97_06650	COG0563	adenylate kinase activity
K5K97_06655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5K97_06660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5K97_06665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5K97_06670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5K97_06675	COG0202	RNA polymerase activity
K5K97_06680	COG0203	ribosomal protein L17
K5K97_06685	COG1122	ATPase activity
K5K97_06690	COG1122	ATPase activity
K5K97_06705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5K97_06710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5K97_06750	COG1002	Type II restriction enzyme, methylase subunits
K5K97_06755	COG1061	Type III restriction enzyme res subunit
K5K97_06760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K97_06765	COG0346	lactoylglutathione lyase activity
K5K97_06775	COG1309	transcriptional regulator
K5K97_06815	COG1846	Transcriptional regulator
K5K97_06820	COG0778	Nitroreductase
K5K97_06825	COG3759	membrane
K5K97_06855	COG0475	glutathione-regulated potassium exporter activity
K5K97_06865	COG0494	nUDIX hydrolase
K5K97_06880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K97_06885	COG0656	L-ascorbic acid biosynthetic process
K5K97_06895	COG0604	alcohol dehydrogenase
K5K97_06900	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K97_06910	COG1054	Belongs to the UPF0176 family
K5K97_06925	COG1380	Effector of murein hydrolase LrgA
K5K97_06930	COG1346	cytolysis
K5K97_06935	COG1304	FMN binding
K5K97_06950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K97_06955	COG0346	lactoylglutathione lyase activity
K5K97_06965	COG0583	DNA-binding transcription factor activity
K5K97_06970	COG0183	Belongs to the thiolase family
K5K97_06975	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K97_06980	COG1024	Enoyl-CoA hydratase
K5K97_06985	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K5K97_06990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5K97_07020	COG1846	Transcriptional regulator
K5K97_07025	COG0346	lactoylglutathione lyase activity
K5K97_07030	COG0346	lactoylglutathione lyase activity
K5K97_07035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5K97_07040	COG0400	carboxylic ester hydrolase activity
K5K97_07060	COG1737	Transcriptional regulator
K5K97_07065	COG2723	6-phospho-beta-galactosidase activity
K5K97_07075	COG2323	membrane
K5K97_07085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K97_07090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K97_07105	COG1960	acyl-CoA dehydrogenase activity
K5K97_07110	COG0583	DNA-binding transcription factor activity
K5K97_07115	COG0183	Belongs to the thiolase family
K5K97_07120	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K97_07125	COG1024	Enoyl-CoA hydratase
K5K97_07130	COG0427	acetyl-CoA hydrolase
K5K97_07140	COG0110	maltose O-acetyltransferase activity
K5K97_07145	COG0561	phosphatase activity
K5K97_07155	COG1247	-acetyltransferase
K5K97_07160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5K97_07165	COG4166	transmembrane transport
K5K97_07175	COG3279	Response regulator of the LytR AlgR family
K5K97_07205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K97_07230	COG3414	Phosphotransferase system galactitol-specific IIB component
K5K97_07235	COG3775	system Galactitol-specific IIC component
K5K97_07245	COG3711	transcriptional antiterminator
K5K97_07250	COG2814	Major facilitator Superfamily
K5K97_07270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K97_07280	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K97_07285	COG1438	arginine binding
K5K97_07300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K97_07320	COG0564	pseudouridine synthase activity
K5K97_07325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K97_07330	COG3679	Belongs to the UPF0342 family
K5K97_07340	COG4717	serine-type aminopeptidase activity
K5K97_07345	COG3481	metal-dependent phosphohydrolase, HD sub domain
K5K97_07350	COG3764	Sortase (surface protein transpeptidase)
K5K97_07360	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K97_07365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K97_07375	COG0736	holo-[acyl-carrier-protein] synthase activity
K5K97_07395	COG1561	YicC-like family, N-terminal region
K5K97_07400	COG0194	GDP metabolic process
K5K97_07410	COG0384	phenazine biosynthesis protein PhzF
K5K97_07425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5K97_07430	COG0242	peptide deformylase activity
K5K97_07435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5K97_07440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K97_07440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5K97_07450	COG0515	serine threonine protein kinase
K5K97_07450	COG2815	serine threonine protein kinase
K5K97_07455	COG1162	GTPase activity
K5K97_07460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5K97_07465	COG1564	THIamine pyrophosphokinase
K5K97_07470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5K97_07480	COG1461	Dihydroxyacetone kinase
K5K97_07485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5K97_07490	COG0416	fatty acid biosynthetic process
K5K97_07495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K97_07505	COG4608	Belongs to the ABC transporter superfamily
K5K97_07510	COG0601	transmembrane transport
K5K97_07515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K97_07525	COG0571	ribonuclease III activity
K5K97_07530	COG1196	nuclear chromosome segregation
K5K97_07535	COG0561	phosphatase activity
K5K97_07540	COG0552	protein localization to endoplasmic reticulum
K5K97_07545	COG1349	DNA-binding transcription factor activity
K5K97_07550	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K97_07555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K97_07555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K97_07555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K97_07560	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K97_07560	COG2918	glutathione biosynthetic process
K5K97_07565	COG2723	6-phospho-beta-galactosidase activity
K5K97_07570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_07575	COG2188	Transcriptional regulator
K5K97_07590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5K97_07595	COG5506	Protein of unknown function (DUF1694)
K5K97_07600	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5K97_07605	COG4605	iron ion homeostasis
K5K97_07610	COG4604	ABC transporter, ATP-binding protein
K5K97_07615	COG4607	ABC-type enterochelin transport system periplasmic component
K5K97_07620	COG1053	succinate dehydrogenase
K5K97_07620	COG3976	FMN-binding domain protein
K5K97_07630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_07645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K5K97_07665	COG1737	Transcriptional regulator
K5K97_07670	COG0415	Belongs to the DNA photolyase family
K5K97_07675	COG2188	Transcriptional regulator
K5K97_07680	COG1263	PTS System
K5K97_07680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_07685	COG0366	Alpha amylase catalytic
K5K97_07690	COG1418	mRNA catabolic process
K5K97_07695	COG0456	acetyltransferase
K5K97_07700	COG2207	Transcriptional regulator
K5K97_07700	COG3708	Transcriptional regulator
K5K97_07710	COG1914	H( )-stimulated, divalent metal cation uptake system
K5K97_07720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K97_07720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K97_07725	COG0084	hydrolase, TatD family'
K5K97_07730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K5K97_07735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5K97_07745	COG3842	ATPase activity
K5K97_07750	COG1803	Methylglyoxal synthase
K5K97_07760	COG4221	oxidoreductase activity
K5K97_07765	COG0789	Transcriptional regulator
K5K97_07770	COG1011	Hydrolase
K5K97_07785	COG1132	(ABC) transporter
K5K97_07790	COG1132	(ABC) transporter
K5K97_07800	COG3584	3D domain protein
K5K97_07800	COG1388	LysM domain
K5K97_07815	COG1309	transcriptional regulator
K5K97_07825	COG3859	Proton-coupled thiamine transporter YuaJ
K5K97_07845	COG4684	Psort location CytoplasmicMembrane, score
K5K97_07850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5K97_07865	COG1692	metallophosphoesterase
K5K97_07875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K97_07880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5K97_07885	COG0424	maF-like protein
K5K97_07895	COG0632	four-way junction helicase activity
K5K97_07900	COG2255	four-way junction helicase activity
K5K97_07905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5K97_07910	COG0343	queuine tRNA-ribosyltransferase activity
K5K97_07925	COG1454	alcohol dehydrogenase
K5K97_07925	COG1012	belongs to the aldehyde dehydrogenase family
K5K97_07930	COG1792	Involved in formation and maintenance of cell shape
K5K97_07960	COG0217	transcriptional regulatory protein
K5K97_07970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5K97_07980	COG4537	Required for transformation and DNA binding
K5K97_08010	COG0827	DNA restriction-modification system
K5K97_08015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5K97_08035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5K97_08045	COG2264	protein methyltransferase activity
K5K97_08050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5K97_08060	COG3878	Protein conserved in bacteria
K5K97_08070	COG0640	Transcriptional regulator
K5K97_08075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5K97_08085	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K97_08105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K97_08125	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5K97_08130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5K97_08135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K97_08140	COG2226	methyltransferase
K5K97_08150	COG2827	Endonuclease containing a URI domain
K5K97_08155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5K97_08160	COG0204	Acyl-transferase
K5K97_08165	COG1131	(ABC) transporter
K5K97_08175	COG1309	transcriptional regulator
K5K97_08180	COG0420	3'-5' exonuclease activity
K5K97_08185	COG0419	ATPase involved in DNA repair
K5K97_08190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5K97_08195	COG1132	(ABC) transporter
K5K97_08200	COG4720	Psort location CytoplasmicMembrane, score
K5K97_08205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5K97_08210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K97_08220	COG2814	Major facilitator Superfamily
K5K97_08225	COG4109	DRTGG domain
K5K97_08230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5K97_08245	COG0583	DNA-binding transcription factor activity
K5K97_08250	COG4670	ketone body catabolic process
K5K97_08255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K97_08265	COG0583	DNA-binding transcription factor activity
K5K97_08270	COG1028	Short-chain dehydrogenase reductase Sdr
K5K97_08275	COG0183	Belongs to the thiolase family
K5K97_08295	COG1012	belongs to the aldehyde dehydrogenase family
K5K97_08295	COG1454	alcohol dehydrogenase
K5K97_08330	COG0783	Belongs to the Dps family
K5K97_08340	COG0459	protein refolding
K5K97_08355	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K97_08360	COG0488	(ABC) transporter
K5K97_08365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5K97_08375	COG1164	Oligoendopeptidase f
K5K97_08385	COG4116	CYTH
K5K97_08390	COG2357	RelA SpoT domain protein
K5K97_08395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5K97_08400	COG0564	pseudouridine synthase activity
K5K97_08405	COG2239	Acts as a magnesium transporter
K5K97_08410	COG0456	acetyltransferase
K5K97_08420	COG1131	(ABC) transporter
K5K97_08425	COG0842	Transport permease protein
K5K97_08430	COG0251	oxidation-reduction process
K5K97_08435	COG0626	cystathionine gamma-synthase activity
K5K97_08440	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5K97_08440	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K97_08445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K97_08450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K97_08455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K97_08480	COG3142	Participates in the control of copper homeostasis
K5K97_08485	COG0500	methyltransferase
K5K97_08490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5K97_08495	COG0406	alpha-ribazole phosphatase activity
K5K97_08500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5K97_08520	COG1597	lipid kinase activity
K5K97_08525	COG0431	NADPH-dependent FMN reductase
K5K97_08530	COG0456	acetyltransferase
K5K97_08545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K97_08555	COG0250	Participates in transcription elongation, termination and antitermination
K5K97_08565	COG1757	Na H antiporter
K5K97_08580	COG1760	l-serine dehydratase
K5K97_08585	COG1760	l-serine dehydratase
K5K97_08590	COG1058	Belongs to the CinA family
K5K97_08590	COG1546	Belongs to the CinA family
K5K97_08595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5K97_08600	COG1418	mRNA catabolic process
K5K97_08605	COG1917	Cupin 2, conserved barrel domain protein
K5K97_08605	COG2207	Transcriptional regulator
K5K97_08610	COG0673	inositol 2-dehydrogenase activity
K5K97_08630	COG0673	inositol 2-dehydrogenase activity
K5K97_08635	COG2217	Heavy metal translocating P-type atpase
K5K97_08645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5K97_08650	COG0081	regulation of translation
K5K97_08655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5K97_08660	COG0222	ribosome binding
K5K97_08665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K5K97_08670	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K5K97_08675	COG4122	O-methyltransferase activity
K5K97_08690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5K97_08695	COG2868	ribosomal protein
K5K97_08700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5K97_08705	COG0006	proline dipeptidase activity
K5K97_08710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K97_08715	COG1302	Protein conserved in bacteria
K5K97_08720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K97_08725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5K97_08730	COG1570	exodeoxyribonuclease VII activity
K5K97_08735	COG1722	exodeoxyribonuclease VII activity
K5K97_08745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K5K97_08750	COG1438	arginine binding
K5K97_08755	COG0497	DNA recombination
K5K97_08770	COG2001	Belongs to the MraZ family
K5K97_08775	COG0275	rRNA processing
K5K97_08785	COG0768	penicillin binding
K5K97_08790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K97_08795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5K97_08800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5K97_08805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5K97_08810	COG0849	cell division
K5K97_08815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5K97_08820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5K97_08825	COG1799	cell septum assembly
K5K97_08835	COG2302	S4 RNA-binding domain
K5K97_08840	COG3599	regulation of cell shape
K5K97_08845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5K97_08855	COG1174	glycine betaine transport
K5K97_08870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5K97_08880	COG0436	Aminotransferase
K5K97_08895	COG0006	proline dipeptidase activity
K5K97_08940	COG2268	Band 7 protein
K5K97_08955	COG0789	Transcriptional regulator
K5K97_08965	COG0384	phenazine biosynthesis protein PhzF
K5K97_08980	COG4129	membrane
K5K97_08990	COG1876	peptidase activity
K5K97_08995	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K97_09005	COG0681	Belongs to the peptidase S26 family
K5K97_09020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5K97_09030	COG2183	response to ionizing radiation
K5K97_09035	COG3091	SprT-like family
K5K97_09055	COG3594	Acyltransferase
K5K97_09070	COG0561	phosphatase activity
K5K97_09085	COG0527	aspartate kinase activity
K5K97_09090	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K5K97_09095	COG1104	cysteine desulfurase activity
K5K97_09100	COG0301	tRNA thio-modification
K5K97_09105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K97_09115	COG0525	valine-tRNA ligase activity
K5K97_09120	COG0285	dihydrofolate synthase activity
K5K97_09125	COG0546	phosphoglycolate phosphatase activity
K5K97_09130	COG2003	Belongs to the UPF0758 family
K5K97_09135	COG1278	Cold shock
K5K97_09145	COG5503	Protein of unknown function (DUF1447)
K5K97_09150	COG2388	GCN5-related N-acetyl-transferase
K5K97_09165	COG1132	(ABC) transporter
K5K97_09190	COG0513	Belongs to the DEAD box helicase family
K5K97_09195	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K97_09195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K97_09205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_09225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_09230	COG1447	Phosphotransferase system cellobiose-specific component IIA
K5K97_09250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K97_09335	COG0629	single-stranded DNA binding
K5K97_09495	COG5263	repeat protein
K5K97_09495	COG5632	N-Acetylmuramoyl-L-alanine amidase
K5K97_09505	COG1316	TRANSCRIPTIONal
K5K97_09510	COG0745	RESPONSE REGULATOR receiver
K5K97_09520	COG0726	polysaccharide deacetylase
K5K97_09525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K97_09530	COG2309	aminopeptidase activity
K5K97_09540	COG0716	FMN binding
K5K97_09545	COG0024	Methionine aminopeptidase
K5K97_09550	COG1295	ribonuclease BN
K5K97_09560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K97_09565	COG1316	TRANSCRIPTIONal
K5K97_09570	COG1134	teichoic acid transport
K5K97_09575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K97_09580	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K5K97_09585	COG1682	transport, permease protein
K5K97_09590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K97_09595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K97_09605	COG0489	protein tyrosine kinase activity
K5K97_09610	COG4464	protein tyrosine phosphatase activity
K5K97_09620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5K97_09630	COG0438	transferase activity, transferring glycosyl groups
K5K97_09635	COG0438	transferase activity, transferring glycosyl groups
K5K97_09655	COG0463	Glycosyl transferase, family 2
K5K97_09665	COG1086	Polysaccharide biosynthesis protein
K5K97_09690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K97_09695	COG1316	TRANSCRIPTIONal
K5K97_09700	COG0589	response to stress
K5K97_09730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5K97_09735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5K97_09740	COG2137	regulation of response to DNA damage stimulus
K5K97_09745	COG1194	a g-specific adenine glycosylase
K5K97_09750	COG3557	Belongs to the UPF0374 family
K5K97_09765	COG2153	protein acetylation
K5K97_09770	COG0628	permease
K5K97_09775	COG1253	flavin adenine dinucleotide binding
K5K97_09780	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K97_09800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5K97_09810	COG0542	response to heat
K5K97_09825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K97_09830	COG0438	transferase activity, transferring glycosyl groups
K5K97_09835	COG0438	transferase activity, transferring glycosyl groups
K5K97_09845	COG2084	Dehydrogenase
K5K97_09850	COG4703	Protein of unknown function (DUF1797)
K5K97_09860	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5K97_09865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5K97_09875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K97_09880	COG0745	RESPONSE REGULATOR receiver
K5K97_09885	COG5002	protein histidine kinase activity
K5K97_09895	COG2217	Heavy metal translocating P-type atpase
K5K97_09910	COG2514	catechol 2,3-dioxygenase activity
K5K97_09915	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K97_09920	COG0584	glycerophosphoryl diester phosphodiesterase
K5K97_09925	COG3942	CHAP domain
K5K97_09925	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K97_09930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5K97_09935	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K5K97_09945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5K97_09950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K5K97_09960	COG0436	Aminotransferase
K5K97_09965	COG1126	abc transporter atp-binding protein
K5K97_09970	COG0765	amino acid transport
K5K97_09975	COG0371	Dehydrogenase
K5K97_09980	COG2723	6-phospho-beta-galactosidase activity
K5K97_09995	COG4948	Mandelate Racemase Muconate Lactonizing
K5K97_10005	COG4166	transmembrane transport
K5K97_10010	COG4166	transmembrane transport
K5K97_10015	COG4166	transmembrane transport
K5K97_10020	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K97_10035	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K97_10035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K97_10040	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K97_10040	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_10050	COG3715	PTS system
K5K97_10055	COG3716	PTS system mannose fructose sorbose family IID component
K5K97_10065	COG4166	transmembrane transport
K5K97_10075	COG0601	transmembrane transport
K5K97_10080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K97_10085	COG0444	Belongs to the ABC transporter superfamily
K5K97_10090	COG4608	Belongs to the ABC transporter superfamily
K5K97_10110	COG1446	asparaginase
K5K97_10115	COG2188	Transcriptional regulator
K5K97_10120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K97_10130	COG0390	transport system, permease component
K5K97_10135	COG4619	ABC transporter
K5K97_10140	COG0572	uridine kinase
K5K97_10145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K97_10150	COG1098	S1 RNA binding domain
K5K97_10200	COG2246	polysaccharide biosynthetic process
K5K97_10210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5K97_10210	COG1199	ATP-dependent helicase activity
K5K97_10220	COG0436	Aminotransferase
K5K97_10230	COG3711	transcriptional antiterminator
K5K97_10235	COG2190	(PTS) system
K5K97_10235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_10235	COG1263	PTS System
K5K97_10240	COG2723	6-phospho-beta-galactosidase activity
K5K97_10245	COG2608	mercury ion transmembrane transporter activity
K5K97_10250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5K97_10260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5K97_10265	COG1316	TRANSCRIPTIONal
K5K97_10270	COG3579	cysteine-type endopeptidase activity
K5K97_10275	COG0556	nucleotide-excision repair
K5K97_10280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5K97_10290	COG1131	(ABC) transporter
K5K97_10295	COG2186	Transcriptional regulator
K5K97_10300	COG1660	Displays ATPase and GTPase activities
K5K97_10310	COG1481	regulation of sporulation
K5K97_10315	COG3284	Transcriptional regulator
K5K97_10320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K97_10325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K97_10330	COG0022	dehydrogenase e1 component
K5K97_10335	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K97_10360	COG0740	serine-type endopeptidase activity
K5K97_10370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5K97_10375	COG2390	Transcriptional regulator
K5K97_10385	COG0126	phosphoglycerate kinase activity
K5K97_10390	COG0149	triose-phosphate isomerase activity
K5K97_10395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5K97_10405	COG4974	Belongs to the 'phage' integrase family
K5K97_10425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5K97_10480	COG0024	Methionine aminopeptidase
K5K97_10490	COG1609	Transcriptional regulator
K5K97_10500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K97_10505	COG1288	antiporter activity
K5K97_10515	COG4988	ABC transporter
K5K97_10520	COG1132	(ABC) transporter
K5K97_10530	COG2508	Transcriptional regulator
K5K97_10535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5K97_10540	COG1304	FMN binding
K5K97_10545	COG0666	response to abiotic stimulus
K5K97_10550	COG1953	Uracil, thiamine, allantoin
K5K97_10555	COG0590	tRNA wobble adenosine to inosine editing
K5K97_10575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K97_10585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K97_10600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K5K97_10620	COG0716	FMN binding
K5K97_10635	COG2378	regulation of single-species biofilm formation
K5K97_10675	COG1942	4-Oxalocrotonate Tautomerase
K5K97_10680	COG3397	chitin binding
K5K97_10695	COG0557	exoribonuclease II activity
K5K97_10700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5K97_10705	COG0356	it plays a direct role in the translocation of protons across the membrane
K5K97_10710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K97_10715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5K97_10720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K97_10725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5K97_10730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5K97_10735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5K97_10740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5K97_10755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K97_10765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5K97_10775	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5K97_10785	COG0411	ABC transporter
K5K97_10795	COG0517	IMP dehydrogenase activity
K5K97_10830	COG1309	transcriptional regulator
K5K97_10840	COG2188	Transcriptional regulator
K5K97_10845	COG1739	Uncharacterized protein family UPF0029
K5K97_10855	COG2267	carboxylic ester hydrolase activity
K5K97_10860	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K5K97_10865	COG1040	competence protein
K5K97_10875	COG0653	protein targeting
K5K97_10885	COG2884	Cell division ATP-binding protein ftsE
K5K97_10890	COG2177	Part of the ABC transporter FtsEX involved in
K5K97_10905	COG0573	inorganic phosphate transmembrane transporter activity
K5K97_10910	COG0581	inorganic phosphate transmembrane transporter activity
K5K97_10915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K97_10920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K97_10925	COG0704	Plays a role in the regulation of phosphate uptake
K5K97_10930	COG1196	nuclear chromosome segregation
K5K97_10930	COG0741	lytic transglycosylase activity
K5K97_10930	COG0739	heme binding
K5K97_10945	COG1950	PFAM Membrane protein of
K5K97_10955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5K97_10960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5K97_10965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5K97_10975	COG1073	alpha beta
K5K97_10980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5K97_10985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5K97_10990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5K97_10995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5K97_11000	COG3870	Protein conserved in bacteria
K5K97_11005	COG0470	DNA polymerase III
K5K97_11010	COG1774	PSP1 C-terminal conserved region
K5K97_11015	COG4467	Involved in initiation control of chromosome replication
K5K97_11035	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K97_11035	COG3942	CHAP domain
K5K97_11040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K97_11045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K97_11055	COG4989	oxidoreductase activity
K5K97_11060	COG1131	(ABC) transporter
K5K97_11070	COG0516	GMP reductase activity
K5K97_11075	COG2962	Rard protein
K5K97_11080	COG0561	phosphatase activity
K5K97_11085	COG1078	dGTPase activity
K5K97_11090	COG0095	Lipoate-protein ligase
K5K97_11100	COG3343	RNA polymerase activity
K5K97_11110	COG1012	belongs to the aldehyde dehydrogenase family
K5K97_11120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K97_11125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5K97_11130	COG0254	rRNA binding
K5K97_11135	COG1660	Displays ATPase and GTPase activities
K5K97_11140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5K97_11145	COG1368	sulfuric ester hydrolase activity
K5K97_11150	COG1476	TRANSCRIPTIONal
K5K97_11165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K97_11180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K97_11185	COG0488	(ABC) transporter
K5K97_11210	COG1131	(ABC) transporter
K5K97_11220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K97_11220	COG0574	Belongs to the PEP-utilizing enzyme family
K5K97_11225	COG0517	IMP dehydrogenase activity
K5K97_11230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K97_11240	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K5K97_11245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5K97_11260	COG0488	(ABC) transporter
K5K97_11265	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K97_11270	COG1937	Protein conserved in bacteria
K5K97_11280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K97_11285	COG2011	ABC-type metal ion transport system permease component
K5K97_11290	COG1464	Belongs to the NlpA lipoprotein family
K5K97_11300	COG0719	Fe-S assembly protein
K5K97_11305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5K97_11310	COG0822	iron-sulfur transferase activity
K5K97_11315	COG0719	Fe-S assembly protein
K5K97_11345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K97_11350	COG1609	Transcriptional regulator
K5K97_11350	COG2207	Transcriptional regulator
K5K97_11355	COG3250	beta-galactosidase activity
K5K97_11360	COG0789	Transcriptional regulator
K5K97_11360	COG4978	Transcriptional regulator
K5K97_11380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K5K97_11395	COG1882	Formate acetyltransferase
K5K97_11400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5K97_11450	COG1454	alcohol dehydrogenase
K5K97_11450	COG1012	belongs to the aldehyde dehydrogenase family
K5K97_11455	COG4869	propanediol catabolic process
K5K97_11465	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K97_11525	COG4565	transcriptional regulatory protein
K5K97_11530	COG3290	protein histidine kinase activity
K5K97_11535	COG3493	citrate carrier protein
K5K97_11575	COG0673	inositol 2-dehydrogenase activity
K5K97_11580	COG2182	Extracellular solute-binding protein
K5K97_11585	COG1175	transmembrane transport
K5K97_11590	COG0395	ABC-type sugar transport system, permease component
K5K97_11605	COG0673	inositol 2-dehydrogenase activity
K5K97_11635	COG0673	inositol 2-dehydrogenase activity
K5K97_11660	COG2223	nitrite transmembrane transporter activity
K5K97_11665	COG1671	Belongs to the UPF0178 family
K5K97_11670	COG4807	Protein conserved in bacteria
K5K97_11675	COG0386	Belongs to the glutathione peroxidase family
K5K97_11680	COG0280	phosphate acetyltransferase
K5K97_11685	COG3426	butyrate kinase activity
K5K97_11690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K97_11695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K97_11700	COG0022	dehydrogenase e1 component
K5K97_11705	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K97_11715	COG0583	DNA-binding transcription factor activity
K5K97_11720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K97_11735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K97_11750	COG2860	membrane
K5K97_11755	COG0514	ATP-dependent DNA helicase (RecQ)
K5K97_11765	COG1979	alcohol dehydrogenase
K5K97_11775	COG0583	DNA-binding transcription factor activity
K5K97_11800	COG1953	Uracil, thiamine, allantoin
K5K97_11805	COG0737	Belongs to the 5'-nucleotidase family
K5K97_11820	COG1129	ABC transporter
K5K97_11840	COG0656	L-ascorbic acid biosynthetic process
K5K97_11845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K97_11850	COG1104	cysteine desulfurase activity
K5K97_11860	COG2184	nucleotidyltransferase activity
K5K97_11875	COG2814	Major facilitator Superfamily
K5K97_11890	COG0482	sulfurtransferase activity
K5K97_11900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K97_11915	COG1012	belongs to the aldehyde dehydrogenase family
K5K97_11920	COG1674	ftsk spoiiie
K5K97_11920	COG1280	lysine exporter protein (LysE YggA)
K5K97_11940	COG0025	NhaP-type Na H and K H
K5K97_11945	COG1136	(ABC) transporter
K5K97_11950	COG0577	efflux transmembrane transporter activity
K5K97_11960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5K97_11965	COG1131	(ABC) transporter
K5K97_11975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K97_11980	COG0768	penicillin binding
K5K97_11985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K97_12010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5K97_12015	COG0705	Rhomboid family
K5K97_12015	COG0457	Tetratricopeptide repeat
K5K97_12025	COG1940	carbohydrate kinase activity
K5K97_12030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5K97_12040	COG0584	glycerophosphoryl diester phosphodiesterase
K5K97_12045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5K97_12050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5K97_12055	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K5K97_12060	COG0789	Transcriptional regulator
K5K97_12070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K97_12085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K97_12090	COG0742	ribosomal rna small subunit methyltransferase
K5K97_12095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5K97_12100	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5K97_12105	COG1555	photosystem II stabilization
K5K97_12110	COG2131	deaminase
K5K97_12115	COG2333	competence protein COMEC
K5K97_12115	COG0658	competence protein
K5K97_12120	COG1466	dna polymerase III delta subunit
K5K97_12130	COG1307	EDD domain protein, DegV family
K5K97_12140	COG1307	EDD domain protein, DegV family
K5K97_12145	COG2217	Heavy metal translocating P-type atpase
K5K97_12150	COG1968	undecaprenyl-diphosphatase activity
K5K97_12160	COG0789	Transcriptional regulator
K5K97_12175	COG0588	phosphoglycerate mutase activity
K5K97_12180	COG0052	Belongs to the universal ribosomal protein uS2 family
K5K97_12185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5K97_12190	COG0528	UMP kinase activity
K5K97_12195	COG0233	cytoplasmic translational termination
K5K97_12200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5K97_12205	COG4589	Belongs to the CDS family
K5K97_12210	COG0750	zinc metalloprotease
K5K97_12215	COG0442	prolyl-tRNA aminoacylation
K5K97_12225	COG1408	metallophosphoesterase
K5K97_12230	COG0779	Required for maturation of 30S ribosomal subunits
K5K97_12235	COG0195	Participates in both transcription termination and antitermination
K5K97_12240	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K5K97_12255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5K97_12260	COG0673	inositol 2-dehydrogenase activity
K5K97_12265	COG1363	Peptidase, m42
K5K97_12270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5K97_12275	COG0196	riboflavin kinase activity
K5K97_12280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5K97_12285	COG1420	regulation of RNA biosynthetic process
K5K97_12290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5K97_12295	COG0443	Heat shock 70 kDa protein
K5K97_12300	COG0484	heat shock protein binding
K5K97_12305	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K97_12315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5K97_12320	COG1132	(ABC) transporter
K5K97_12325	COG1132	(ABC) transporter
K5K97_12330	COG0745	RESPONSE REGULATOR receiver
K5K97_12335	COG5002	protein histidine kinase activity
K5K97_12340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K5K97_12345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5K97_12365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K5K97_12370	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K5K97_12375	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K5K97_12385	COG0745	RESPONSE REGULATOR receiver
K5K97_12400	COG1131	(ABC) transporter
K5K97_12415	COG1837	Belongs to the UPF0109 family
K5K97_12425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5K97_12430	COG0336	Belongs to the RNA methyltransferase TrmD family
K5K97_12435	COG0335	large ribosomal subunit rRNA binding
K5K97_12440	COG1764	response to oxidative stress
K5K97_12445	COG2190	(PTS) system
K5K97_12445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_12445	COG1263	PTS System
K5K97_12450	COG2723	6-phospho-beta-galactosidase activity
K5K97_12460	COG1193	negative regulation of DNA recombination
K5K97_12470	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K5K97_12490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K97_12495	COG1522	sequence-specific DNA binding
K5K97_12500	COG0436	Aminotransferase
K5K97_12510	COG3711	transcriptional antiterminator
K5K97_12515	COG2190	(PTS) system
K5K97_12515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K97_12515	COG1263	PTS System
K5K97_12520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K97_12525	COG0577	efflux transmembrane transporter activity
K5K97_12530	COG1136	(ABC) transporter
K5K97_12540	COG0745	RESPONSE REGULATOR receiver
K5K97_12550	COG1609	Transcriptional regulator
K5K97_12560	COG0772	Belongs to the SEDS family
K5K97_12580	COG4753	response regulator
K5K97_12580	COG2207	Transcriptional regulator
K5K97_12590	COG1027	Aspartate ammonia-lyase
K5K97_12595	COG0281	malic enzyme
K5K97_12600	COG0114	fumarate hydratase activity
K5K97_12610	COG0745	RESPONSE REGULATOR receiver
K5K97_12615	COG5002	protein histidine kinase activity
K5K97_12630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5K97_12635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5K97_12640	COG4166	transmembrane transport
K5K97_12645	COG0477	Major facilitator Superfamily
K5K97_12650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5K97_12655	COG0509	glycine decarboxylation via glycine cleavage system
K5K97_12660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K97_12665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K97_12695	COG0406	alpha-ribazole phosphatase activity
K5K97_12705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5K97_12710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5K97_12715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K5K97_12720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5K97_12725	COG0287	Prephenate dehydrogenase
K5K97_12735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5K97_12740	COG0077	Prephenate dehydratase
K5K97_12750	COG1307	EDD domain protein, DegV family
K5K97_12755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5K97_12765	COG0513	Belongs to the DEAD box helicase family
K5K97_12770	COG1959	2 iron, 2 sulfur cluster binding
K5K97_12775	COG2910	NAD(P)H-binding
K5K97_12780	COG2153	protein acetylation
K5K97_12785	COG2267	carboxylic ester hydrolase activity
K5K97_12790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5K97_12795	COG1136	(ABC) transporter
K5K97_12800	COG0577	efflux transmembrane transporter activity
K5K97_12840	COG3646	Phage regulatory protein
K5K97_12840	COG3645	SOS response
K5K97_12915	COG0629	single-stranded DNA binding
K5K97_12990	COG3728	DNA packaging
K5K97_12990	COG5484	DNA packaging
K5K97_13095	COG3594	Acyltransferase
K5K97_13145	COG1131	(ABC) transporter
K5K97_13150	COG1725	Transcriptional regulator
K5K97_13165	COG2814	Major facilitator Superfamily
K5K97_13175	COG0587	DNA-directed DNA polymerase activity
K5K97_13180	COG0205	6-phosphofructokinase activity
K5K97_13190	COG2814	Major facilitator Superfamily
K5K97_13205	COG2996	Protein conserved in bacteria
K5K97_13210	COG0735	belongs to the Fur family
K5K97_13215	COG0519	Catalyzes the synthesis of GMP from XMP
K5K97_13225	COG4974	Belongs to the 'phage' integrase family
K5K97_13230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5K97_13235	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5K97_13240	COG1187	pseudouridine synthase activity
K5K97_13245	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5K97_13250	COG2755	lipolytic protein G-D-S-L family
K5K97_13250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5K97_13265	COG0514	ATP-dependent DNA helicase (RecQ)
K5K97_13270	COG1388	LysM domain
K5K97_13270	COG1134	teichoic acid transport
K5K97_13275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5K97_13280	COG0539	negative regulation of cytoplasmic translation
K5K97_13285	COG1160	GTP binding
K5K97_13310	COG5582	Belongs to the UPF0302 family
K5K97_13320	COG0583	DNA-binding transcription factor activity
K5K97_13350	COG0280	phosphate acetyltransferase
K5K97_13355	COG3426	butyrate kinase activity
K5K97_13365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K97_13370	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K97_13375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5K97_13380	COG0617	tRNA 3'-terminal CCA addition
K5K97_13395	COG0488	(ABC) transporter
K5K97_13400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5K97_13415	COG1272	protein, Hemolysin III
K5K97_13420	COG1307	EDD domain protein, DegV family
K5K97_13425	COG2755	lipolytic protein G-D-S-L family
K5K97_13440	COG4479	Belongs to the UPF0346 family
K5K97_13445	COG3409	Peptidoglycan-binding domain 1 protein
K5K97_13445	COG0793	Belongs to the peptidase S41A family
K5K97_13455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K97_13460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K97_13465	COG0758	DNA mediated transformation
K5K97_13470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5K97_13475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K5K97_13480	COG4974	Belongs to the 'phage' integrase family
K5K97_13485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5K97_13490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5K97_13495	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K5K97_13505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K97_13510	COG0735	belongs to the Fur family
K5K97_13520	COG1702	phosphate starvation-inducible protein PhoH
K5K97_13530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5K97_13535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5K97_13540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5K97_13545	COG1381	Involved in DNA repair and RecF pathway recombination
K5K97_13550	COG0752	glycyl-tRNA synthetase alpha subunit
K5K97_13555	COG0751	glycine-tRNA ligase activity
K5K97_13560	COG0577	efflux transmembrane transporter activity
K5K97_13565	COG1136	(ABC) transporter
K5K97_13570	COG0515	serine threonine protein kinase
K5K97_13575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K97_13580	COG0358	DNA primase activity
K5K97_13585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5K97_13590	COG2384	SAM-dependent methyltransferase
K5K97_13595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5K97_13600	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K97_13610	COG0463	Glycosyl transferase, family 2
K5K97_13615	COG0456	acetyltransferase
K5K97_13620	COG0542	response to heat
K5K97_13635	COG0481	GTPase activity
K5K97_13695	COG4895	conserved protein (DUF2196)
K5K97_13710	COG1472	Belongs to the glycosyl hydrolase 3 family
K5K97_13715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5K97_13720	COG0768	penicillin binding
K5K97_13735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K97_13740	COG1136	(ABC) transporter
K5K97_13740	COG0577	efflux transmembrane transporter activity
K5K97_13740	COG0577	efflux transmembrane transporter activity
K5K97_13740	COG1136	(ABC) transporter
K5K97_13770	COG3328	transposase activity
K5K97_13810	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5K97_13815	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5K97_13835	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K5K97_13845	COG0531	amino acid
K5K97_13850	COG1278	Cold shock
K5K97_13880	COG0284	orotidine-5'-phosphate decarboxylase activity
K5K97_13885	COG0167	dihydroorotate dehydrogenase activity
K5K97_13890	COG0543	2 iron, 2 sulfur cluster binding
K5K97_13895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5K97_13900	COG0505	Belongs to the CarA family
K5K97_13905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5K97_13910	COG0540	Belongs to the ATCase OTCase family
K5K97_13915	COG2233	PERMEase
K5K97_13925	COG0564	pseudouridine synthase activity
K5K97_13930	COG4990	cell redox homeostasis
K5K97_13935	COG1516	flagellar protein fliS
K5K97_13945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K5K97_13970	COG1256	bacterial-type flagellum assembly
K5K97_13970	COG4786	Flagellar basal body rod
K5K97_13985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5K97_13985	COG1776	CheC inhibitor of MCP methylation
K5K97_13990	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5K97_13995	COG0835	chemotaxis
K5K97_14000	COG2201	protein-glutamate methylesterase activity
K5K97_14005	COG1776	CheC inhibitor of MCP methylation
K5K97_14010	COG0643	Histidine kinase
K5K97_14010	COG2198	Histidine kinase
K5K97_14015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K5K97_14020	COG2201	protein-glutamate methylesterase activity
K5K97_14040	COG0577	efflux transmembrane transporter activity
K5K97_14040	COG1136	(ABC) transporter