locus-tag	class	description
K5K98_00005	COG0366	Alpha amylase catalytic
K5K98_00010	COG1960	acyl-CoA dehydrogenase activity
K5K98_00015	COG0583	DNA-binding transcription factor activity
K5K98_00020	COG0183	Belongs to the thiolase family
K5K98_00025	COG1960	acyl-CoA dehydrogenase activity
K5K98_00030	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K98_00035	COG1024	Enoyl-CoA hydratase
K5K98_00040	COG0427	acetyl-CoA hydrolase
K5K98_00045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5K98_00050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K98_00055	COG0351	phosphomethylpyrimidine kinase
K5K98_00060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K98_00095	COG0504	CTP synthase activity
K5K98_00115	COG1136	(ABC) transporter
K5K98_00115	COG0577	efflux transmembrane transporter activity
K5K98_00120	COG0577	efflux transmembrane transporter activity
K5K98_00120	COG1136	(ABC) transporter
K5K98_00135	COG3425	synthase
K5K98_00140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5K98_00145	COG1363	Peptidase, m42
K5K98_00160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K98_00175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_00190	COG2807	transmembrane transport
K5K98_00195	COG2807	transmembrane transport
K5K98_00200	COG1396	sequence-specific DNA binding
K5K98_00220	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K5K98_00225	COG1074	ATP-dependent DNA helicase activity
K5K98_00240	COG3853	Toxic anion resistance protein (TelA)
K5K98_00245	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K5K98_00260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K98_00265	COG1335	isochorismatase
K5K98_00270	COG2855	membrane
K5K98_00285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K98_00290	COG2706	6-phosphogluconolactonase activity
K5K98_00305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5K98_00310	COG1435	thymidine kinase activity
K5K98_00315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5K98_00320	COG2890	protein-(glutamine-N5) methyltransferase activity
K5K98_00325	COG0009	L-threonylcarbamoyladenylate synthase
K5K98_00330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5K98_00335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5K98_00350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5K98_00355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K98_00375	COG0116	Belongs to the methyltransferase superfamily
K5K98_00380	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5K98_00385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K98_00390	COG3588	fructose-bisphosphate aldolase
K5K98_00395	COG2188	Transcriptional regulator
K5K98_00400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_00410	COG3964	amidohydrolase
K5K98_00430	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K98_00445	COG1131	(ABC) transporter
K5K98_00455	COG2365	Tyrosine phosphatase family
K5K98_00460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K98_00465	COG0737	Belongs to the 5'-nucleotidase family
K5K98_00470	COG4470	Protein conserved in bacteria
K5K98_00475	COG0647	UMP catabolic process
K5K98_00485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5K98_00490	COG0492	ferredoxin-NADP+ reductase activity
K5K98_00505	COG1132	(ABC) transporter
K5K98_00520	COG1482	cell wall glycoprotein biosynthetic process
K5K98_00525	COG1609	Transcriptional regulator
K5K98_00530	COG0686	Belongs to the AlaDH PNT family
K5K98_00535	COG3442	glutamine amidotransferase
K5K98_00540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K98_00550	COG0601	transmembrane transport
K5K98_00555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K98_00560	COG0444	Belongs to the ABC transporter superfamily
K5K98_00565	COG4608	Belongs to the ABC transporter superfamily
K5K98_00575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K98_00590	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5K98_00595	COG0328	RNA-DNA hybrid ribonuclease activity
K5K98_00605	COG1278	Cold shock
K5K98_00610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5K98_00615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5K98_00620	COG0735	belongs to the Fur family
K5K98_00745	COG1696	Membrane protein involved in D-alanine export
K5K98_00750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K98_00755	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K5K98_00765	COG2391	methyltransferase activity
K5K98_00770	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K98_00775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K98_00780	COG4521	taurine ABC transporter
K5K98_00785	COG1116	anion transmembrane transporter activity
K5K98_00790	COG0741	lytic transglycosylase activity
K5K98_00795	COG0726	polysaccharide deacetylase
K5K98_00800	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K5K98_00800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5K98_00805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K98_00810	COG1175	transmembrane transport
K5K98_00815	COG0395	ABC-type sugar transport system, permease component
K5K98_00820	COG1653	transport
K5K98_00830	COG2972	Histidine kinase
K5K98_00835	COG4753	response regulator
K5K98_00835	COG2207	Transcriptional regulator
K5K98_00850	COG2824	Alkylphosphonate utilization operon protein PhnA
K5K98_00855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5K98_00860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5K98_00870	COG4585	Histidine kinase
K5K98_00875	COG2197	response regulator
K5K98_00880	COG0569	domain protein
K5K98_00885	COG4841	protein insertion into membrane
K5K98_00895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5K98_00900	COG4838	Belongs to the UPF0358 family
K5K98_00905	COG0772	Belongs to the SEDS family
K5K98_00910	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K5K98_00920	COG3679	Belongs to the UPF0342 family
K5K98_00925	COG4471	UPF0298 protein
K5K98_00935	COG0488	(ABC) transporter
K5K98_00945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K98_00950	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5K98_00955	COG1253	flavin adenine dinucleotide binding
K5K98_00960	COG0494	nUDIX hydrolase
K5K98_00965	COG1214	PFAM Peptidase M22, glycoprotease
K5K98_00975	COG0456	acetyltransferase
K5K98_00980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5K98_00990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5K98_01000	COG0517	IMP dehydrogenase activity
K5K98_01010	COG0668	transmembrane transport
K5K98_01025	COG1609	Transcriptional regulator
K5K98_01030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K98_01035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5K98_01040	COG3763	UPF0154 protein
K5K98_01045	COG1132	(ABC) transporter
K5K98_01050	COG1132	(ABC) transporter
K5K98_01060	COG1609	Transcriptional regulator
K5K98_01065	COG0366	Alpha amylase catalytic
K5K98_01075	COG2182	Extracellular solute-binding protein
K5K98_01080	COG1175	transmembrane transport
K5K98_01085	COG3833	ABC-type maltose transport systems, permease component
K5K98_01095	COG0772	Belongs to the SEDS family
K5K98_01100	COG0534	Mate efflux family protein
K5K98_01110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K98_01115	COG0640	Transcriptional regulator
K5K98_01125	COG0083	homoserine kinase activity
K5K98_01135	COG1254	Belongs to the acylphosphatase family
K5K98_01140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K98_01150	COG1733	regulation of RNA biosynthetic process
K5K98_01155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5K98_01160	COG0072	phenylalanine-tRNA ligase activity
K5K98_01160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K98_01165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5K98_01170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5K98_01175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K98_01185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5K98_01190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K98_01200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5K98_01210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5K98_01220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5K98_01225	COG0439	Biotin carboxylase
K5K98_01230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5K98_01235	COG0825	malonyl-CoA metabolic process
K5K98_01245	COG2151	metal-sulfur cluster biosynthetic enzyme
K5K98_01285	COG1523	belongs to the glycosyl hydrolase 13 family
K5K98_01305	COG0737	Belongs to the 5'-nucleotidase family
K5K98_01310	COG0737	Belongs to the 5'-nucleotidase family
K5K98_01350	COG5566	PFAM Mor transcription activator
K5K98_01355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K98_01360	COG1073	alpha beta
K5K98_01365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K98_01420	COG0745	RESPONSE REGULATOR receiver
K5K98_01425	COG3850	Histidine kinase
K5K98_01425	COG5002	protein histidine kinase activity
K5K98_01430	COG4476	Belongs to the UPF0223 family
K5K98_01435	COG0483	inositol monophosphate 1-phosphatase activity
K5K98_01440	COG1217	gtp-binding protein TYPA
K5K98_01455	COG0210	DNA helicase
K5K98_01460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5K98_01465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K98_01470	COG0154	amidase activity
K5K98_01475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K98_01480	COG1597	lipid kinase activity
K5K98_01485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5K98_01520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K98_01535	COG2608	mercury ion transmembrane transporter activity
K5K98_01575	COG2030	dehydratase
K5K98_01590	COG1368	sulfuric ester hydrolase activity
K5K98_01595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5K98_01600	COG0710	3-dehydroquinate dehydratase activity
K5K98_01605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5K98_01610	COG2081	HI0933 family
K5K98_01615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5K98_01620	COG0166	Belongs to the GPI family
K5K98_01645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5K98_01655	COG0670	Belongs to the BI1 family
K5K98_01660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K98_01660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K98_01665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5K98_01670	COG0237	dephospho-CoA kinase activity
K5K98_01675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5K98_01685	COG1484	DNA-dependent DNA replication
K5K98_01695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K98_01700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5K98_01720	COG0765	amino acid transport
K5K98_01725	COG1126	abc transporter atp-binding protein
K5K98_01730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K98_01755	COG0737	Belongs to the 5'-nucleotidase family
K5K98_01775	COG0187	DNA topoisomerase II activity
K5K98_01780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5K98_01785	COG1882	Formate acetyltransferase
K5K98_01790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5K98_01805	COG2076	Multidrug Resistance protein
K5K98_01810	COG2076	Multidrug Resistance protein
K5K98_01815	COG1227	inorganic diphosphatase activity
K5K98_01825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K98_01835	COG0564	pseudouridine synthase activity
K5K98_01845	COG2233	PERMEase
K5K98_01850	COG0540	Belongs to the ATCase OTCase family
K5K98_01855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5K98_01860	COG0505	Belongs to the CarA family
K5K98_01865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5K98_01870	COG0543	2 iron, 2 sulfur cluster binding
K5K98_01875	COG0167	dihydroorotate dehydrogenase activity
K5K98_01880	COG0284	orotidine-5'-phosphate decarboxylase activity
K5K98_01910	COG1278	Cold shock
K5K98_01915	COG0531	amino acid
K5K98_01925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K5K98_01945	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5K98_01950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5K98_01980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K98_02010	COG0577	efflux transmembrane transporter activity
K5K98_02010	COG1136	(ABC) transporter
K5K98_02010	COG0577	efflux transmembrane transporter activity
K5K98_02010	COG1136	(ABC) transporter
K5K98_02015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K98_02035	COG0768	penicillin binding
K5K98_02040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5K98_02045	COG1472	Belongs to the glycosyl hydrolase 3 family
K5K98_02060	COG4895	conserved protein (DUF2196)
K5K98_02080	COG3328	transposase activity
K5K98_02135	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5K98_02135	COG1388	LysM domain
K5K98_02345	COG3935	DnaD domain protein
K5K98_02360	COG3723	Recombinational DNA repair protein, rece pathway
K5K98_02365	COG5377	YqaJ viral recombinase family
K5K98_02420	COG1396	sequence-specific DNA binding
K5K98_02450	COG4974	Belongs to the 'phage' integrase family
K5K98_02455	COG0481	GTPase activity
K5K98_02465	COG0542	response to heat
K5K98_02470	COG0456	acetyltransferase
K5K98_02475	COG0463	Glycosyl transferase, family 2
K5K98_02485	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K98_02490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5K98_02495	COG2384	SAM-dependent methyltransferase
K5K98_02500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5K98_02505	COG0358	DNA primase activity
K5K98_02510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K98_02515	COG0515	serine threonine protein kinase
K5K98_02520	COG1136	(ABC) transporter
K5K98_02525	COG0577	efflux transmembrane transporter activity
K5K98_02530	COG0751	glycine-tRNA ligase activity
K5K98_02535	COG0752	glycyl-tRNA synthetase alpha subunit
K5K98_02540	COG1381	Involved in DNA repair and RecF pathway recombination
K5K98_02545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5K98_02550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5K98_02555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5K98_02565	COG1702	phosphate starvation-inducible protein PhoH
K5K98_02575	COG0735	belongs to the Fur family
K5K98_02580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K98_02595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5K98_02600	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5K98_02605	COG4974	Belongs to the 'phage' integrase family
K5K98_02610	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K5K98_02615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5K98_02620	COG0758	DNA mediated transformation
K5K98_02625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K98_02630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K98_02640	COG0793	Belongs to the peptidase S41A family
K5K98_02640	COG3409	Peptidoglycan-binding domain 1 protein
K5K98_02645	COG4479	Belongs to the UPF0346 family
K5K98_02660	COG2755	lipolytic protein G-D-S-L family
K5K98_02665	COG1307	EDD domain protein, DegV family
K5K98_02670	COG1272	protein, Hemolysin III
K5K98_02685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5K98_02690	COG0488	(ABC) transporter
K5K98_02705	COG0617	tRNA 3'-terminal CCA addition
K5K98_02710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5K98_02715	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K98_02720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K98_02735	COG3426	butyrate kinase activity
K5K98_02740	COG0280	phosphate acetyltransferase
K5K98_02770	COG0583	DNA-binding transcription factor activity
K5K98_02780	COG5582	Belongs to the UPF0302 family
K5K98_02805	COG1160	GTP binding
K5K98_02810	COG0539	negative regulation of cytoplasmic translation
K5K98_02815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5K98_02820	COG1134	teichoic acid transport
K5K98_02820	COG1388	LysM domain
K5K98_02825	COG0514	ATP-dependent DNA helicase (RecQ)
K5K98_02840	COG2755	lipolytic protein G-D-S-L family
K5K98_02840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5K98_02850	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5K98_02855	COG1187	pseudouridine synthase activity
K5K98_02860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5K98_02865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5K98_02870	COG4974	Belongs to the 'phage' integrase family
K5K98_02885	COG0735	belongs to the Fur family
K5K98_02890	COG2996	Protein conserved in bacteria
K5K98_02905	COG2814	Major facilitator Superfamily
K5K98_02915	COG0205	6-phosphofructokinase activity
K5K98_02920	COG0587	DNA-directed DNA polymerase activity
K5K98_02930	COG2814	Major facilitator Superfamily
K5K98_02940	COG2252	PERMEase
K5K98_02945	COG1725	Transcriptional regulator
K5K98_02950	COG1131	(ABC) transporter
K5K98_02975	COG0577	efflux transmembrane transporter activity
K5K98_02985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5K98_02990	COG2267	carboxylic ester hydrolase activity
K5K98_02995	COG2153	protein acetylation
K5K98_03000	COG2910	NAD(P)H-binding
K5K98_03005	COG1959	2 iron, 2 sulfur cluster binding
K5K98_03010	COG0513	Belongs to the DEAD box helicase family
K5K98_03020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5K98_03030	COG1307	EDD domain protein, DegV family
K5K98_03040	COG0077	Prephenate dehydratase
K5K98_03045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5K98_03055	COG0287	Prephenate dehydrogenase
K5K98_03060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5K98_03070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5K98_03075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5K98_03085	COG0588	phosphoglycerate mutase activity
K5K98_03115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K98_03120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K98_03125	COG0509	glycine decarboxylation via glycine cleavage system
K5K98_03130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5K98_03135	COG0477	Major facilitator Superfamily
K5K98_03140	COG4166	transmembrane transport
K5K98_03145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5K98_03150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5K98_03165	COG5002	protein histidine kinase activity
K5K98_03170	COG0745	RESPONSE REGULATOR receiver
K5K98_03175	COG0114	fumarate hydratase activity
K5K98_03180	COG0281	malic enzyme
K5K98_03185	COG1027	Aspartate ammonia-lyase
K5K98_03195	COG4753	response regulator
K5K98_03195	COG2207	Transcriptional regulator
K5K98_03215	COG0772	Belongs to the SEDS family
K5K98_03225	COG1609	Transcriptional regulator
K5K98_03235	COG0745	RESPONSE REGULATOR receiver
K5K98_03245	COG1136	(ABC) transporter
K5K98_03250	COG0577	efflux transmembrane transporter activity
K5K98_03255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K98_03260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_03260	COG2190	(PTS) system
K5K98_03260	COG1263	PTS System
K5K98_03265	COG3711	transcriptional antiterminator
K5K98_03275	COG0436	Aminotransferase
K5K98_03280	COG1522	sequence-specific DNA binding
K5K98_03285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K98_03305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K5K98_03315	COG3711	transcriptional antiterminator
K5K98_03320	COG2723	6-phospho-beta-galactosidase activity
K5K98_03325	COG1263	PTS System
K5K98_03325	COG2190	(PTS) system
K5K98_03325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_03330	COG1764	response to oxidative stress
K5K98_03335	COG0335	large ribosomal subunit rRNA binding
K5K98_03340	COG0336	Belongs to the RNA methyltransferase TrmD family
K5K98_03345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5K98_03355	COG1837	Belongs to the UPF0109 family
K5K98_03365	COG1131	(ABC) transporter
K5K98_03380	COG0745	RESPONSE REGULATOR receiver
K5K98_03385	COG2205	protein histidine kinase activity
K5K98_03400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5K98_03405	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K5K98_03410	COG5002	protein histidine kinase activity
K5K98_03415	COG0745	RESPONSE REGULATOR receiver
K5K98_03420	COG1132	(ABC) transporter
K5K98_03425	COG1132	(ABC) transporter
K5K98_03430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5K98_03440	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K98_03445	COG0484	heat shock protein binding
K5K98_03450	COG0443	Heat shock 70 kDa protein
K5K98_03455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5K98_03460	COG1420	regulation of RNA biosynthetic process
K5K98_03465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5K98_03470	COG0196	riboflavin kinase activity
K5K98_03475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5K98_03480	COG1363	Peptidase, m42
K5K98_03485	COG0673	inositol 2-dehydrogenase activity
K5K98_03495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5K98_03510	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K5K98_03515	COG0195	Participates in both transcription termination and antitermination
K5K98_03520	COG0779	Required for maturation of 30S ribosomal subunits
K5K98_03525	COG1408	metallophosphoesterase
K5K98_03535	COG0442	prolyl-tRNA aminoacylation
K5K98_03540	COG0750	zinc metalloprotease
K5K98_03545	COG4589	Belongs to the CDS family
K5K98_03550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5K98_03555	COG0233	cytoplasmic translational termination
K5K98_03560	COG0528	UMP kinase activity
K5K98_03565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5K98_03570	COG0052	Belongs to the universal ribosomal protein uS2 family
K5K98_03575	COG0588	phosphoglycerate mutase activity
K5K98_03590	COG0789	Transcriptional regulator
K5K98_03600	COG1968	undecaprenyl-diphosphatase activity
K5K98_03605	COG2217	Heavy metal translocating P-type atpase
K5K98_03620	COG1307	EDD domain protein, DegV family
K5K98_03630	COG1466	dna polymerase III delta subunit
K5K98_03635	COG0658	competence protein
K5K98_03635	COG2333	competence protein COMEC
K5K98_03640	COG2131	deaminase
K5K98_03645	COG1555	photosystem II stabilization
K5K98_03650	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5K98_03655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5K98_03660	COG0742	ribosomal rna small subunit methyltransferase
K5K98_03665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K98_03680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K98_03690	COG0789	Transcriptional regulator
K5K98_03695	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K5K98_03700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5K98_03705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5K98_03710	COG0584	glycerophosphoryl diester phosphodiesterase
K5K98_03720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5K98_03725	COG1940	carbohydrate kinase activity
K5K98_03735	COG0457	Tetratricopeptide repeat
K5K98_03735	COG0705	Rhomboid family
K5K98_03740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5K98_03855	COG0740	serine-type endopeptidase activity
K5K98_03970	COG1196	nuclear chromosome segregation
K5K98_04020	COG3561	AntA/AntB antirepressor
K5K98_04035	COG1396	sequence-specific DNA binding
K5K98_04055	COG0582	viral genome integration into host DNA
K5K98_04060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K98_04065	COG0768	penicillin binding
K5K98_04070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K98_04080	COG1131	(ABC) transporter
K5K98_04085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5K98_04095	COG0577	efflux transmembrane transporter activity
K5K98_04100	COG1136	(ABC) transporter
K5K98_04105	COG0025	NhaP-type Na H and K H
K5K98_04110	COG1674	ftsk spoiiie
K5K98_04110	COG1280	lysine exporter protein (LysE YggA)
K5K98_04115	COG1012	belongs to the aldehyde dehydrogenase family
K5K98_04130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K98_04140	COG0482	sulfurtransferase activity
K5K98_04145	COG2814	Major facilitator Superfamily
K5K98_04165	COG0732	type I restriction modification DNA specificity domain
K5K98_04180	COG1104	cysteine desulfurase activity
K5K98_04185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K98_04190	COG0656	L-ascorbic acid biosynthetic process
K5K98_04210	COG1129	ABC transporter
K5K98_04225	COG0737	Belongs to the 5'-nucleotidase family
K5K98_04250	COG0583	DNA-binding transcription factor activity
K5K98_04260	COG1979	alcohol dehydrogenase
K5K98_04270	COG2610	gluconate transmembrane transporter activity
K5K98_04275	COG1012	belongs to the aldehyde dehydrogenase family
K5K98_04285	COG3290	protein histidine kinase activity
K5K98_04285	COG3829	transcription factor binding
K5K98_04290	COG0514	ATP-dependent DNA helicase (RecQ)
K5K98_04295	COG2860	membrane
K5K98_04310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K98_04320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K98_04325	COG0583	DNA-binding transcription factor activity
K5K98_04335	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K98_04340	COG0022	dehydrogenase e1 component
K5K98_04345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K98_04350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K98_04355	COG3426	butyrate kinase activity
K5K98_04360	COG0280	phosphate acetyltransferase
K5K98_04365	COG0386	Belongs to the glutathione peroxidase family
K5K98_04370	COG4807	Protein conserved in bacteria
K5K98_04375	COG1671	Belongs to the UPF0178 family
K5K98_04380	COG2223	nitrite transmembrane transporter activity
K5K98_04405	COG0673	inositol 2-dehydrogenase activity
K5K98_04410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K98_04410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K98_04435	COG0673	inositol 2-dehydrogenase activity
K5K98_04450	COG0395	ABC-type sugar transport system, permease component
K5K98_04455	COG1175	transmembrane transport
K5K98_04460	COG2182	Extracellular solute-binding protein
K5K98_04465	COG0673	inositol 2-dehydrogenase activity
K5K98_04500	COG3493	citrate carrier protein
K5K98_04505	COG3290	protein histidine kinase activity
K5K98_04510	COG4565	transcriptional regulatory protein
K5K98_04580	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K98_04590	COG4869	propanediol catabolic process
K5K98_04595	COG1012	belongs to the aldehyde dehydrogenase family
K5K98_04595	COG1454	alcohol dehydrogenase
K5K98_04645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5K98_04650	COG1882	Formate acetyltransferase
K5K98_04665	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K5K98_04685	COG0789	Transcriptional regulator
K5K98_04685	COG4978	Transcriptional regulator
K5K98_04695	COG1609	Transcriptional regulator
K5K98_04695	COG2207	Transcriptional regulator
K5K98_04700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K98_04745	COG0719	Fe-S assembly protein
K5K98_04755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5K98_04760	COG0719	Fe-S assembly protein
K5K98_04770	COG1464	Belongs to the NlpA lipoprotein family
K5K98_04775	COG2011	ABC-type metal ion transport system permease component
K5K98_04780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K98_04790	COG1937	Protein conserved in bacteria
K5K98_04795	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K98_04800	COG0488	(ABC) transporter
K5K98_04815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5K98_04820	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K5K98_04830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K98_04835	COG0517	IMP dehydrogenase activity
K5K98_04840	COG0574	Belongs to the PEP-utilizing enzyme family
K5K98_04840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K98_04850	COG1131	(ABC) transporter
K5K98_04870	COG0488	(ABC) transporter
K5K98_04875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K98_04880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K98_04895	COG1476	TRANSCRIPTIONal
K5K98_04900	COG1368	sulfuric ester hydrolase activity
K5K98_04905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5K98_04910	COG1660	Displays ATPase and GTPase activities
K5K98_04915	COG0254	rRNA binding
K5K98_04920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5K98_04925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K98_04935	COG1012	belongs to the aldehyde dehydrogenase family
K5K98_04945	COG3343	RNA polymerase activity
K5K98_04955	COG0095	Lipoate-protein ligase
K5K98_04960	COG1078	dGTPase activity
K5K98_04965	COG0561	phosphatase activity
K5K98_04970	COG2962	Rard protein
K5K98_04975	COG0516	GMP reductase activity
K5K98_04985	COG1131	(ABC) transporter
K5K98_04990	COG4989	oxidoreductase activity
K5K98_05000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K98_05005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K98_05010	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K98_05010	COG3942	CHAP domain
K5K98_05035	COG4467	Involved in initiation control of chromosome replication
K5K98_05040	COG1774	PSP1 C-terminal conserved region
K5K98_05045	COG0470	DNA polymerase III
K5K98_05050	COG3870	Protein conserved in bacteria
K5K98_05055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5K98_05060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5K98_05065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5K98_05070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5K98_05075	COG1073	alpha beta
K5K98_05085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5K98_05090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5K98_05095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5K98_05105	COG1950	PFAM Membrane protein of
K5K98_05120	COG1196	nuclear chromosome segregation
K5K98_05120	COG0739	heme binding
K5K98_05120	COG0741	lytic transglycosylase activity
K5K98_05125	COG0704	Plays a role in the regulation of phosphate uptake
K5K98_05130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K98_05135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K98_05140	COG0581	inorganic phosphate transmembrane transporter activity
K5K98_05145	COG0573	inorganic phosphate transmembrane transporter activity
K5K98_05160	COG2177	Part of the ABC transporter FtsEX involved in
K5K98_05165	COG2884	Cell division ATP-binding protein ftsE
K5K98_05175	COG0653	protein targeting
K5K98_05185	COG1040	competence protein
K5K98_05190	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K5K98_05195	COG2267	carboxylic ester hydrolase activity
K5K98_05205	COG1739	Uncharacterized protein family UPF0029
K5K98_05210	COG2188	Transcriptional regulator
K5K98_05220	COG1309	transcriptional regulator
K5K98_05255	COG0517	IMP dehydrogenase activity
K5K98_05265	COG0411	ABC transporter
K5K98_05275	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5K98_05285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5K98_05295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K98_05305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5K98_05310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5K98_05315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5K98_05320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5K98_05325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K98_05330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5K98_05335	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K98_05340	COG0356	it plays a direct role in the translocation of protons across the membrane
K5K98_05345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5K98_05350	COG0557	exoribonuclease II activity
K5K98_05365	COG3397	chitin binding
K5K98_05370	COG1942	4-Oxalocrotonate Tautomerase
K5K98_05415	COG2378	regulation of single-species biofilm formation
K5K98_05430	COG0716	FMN binding
K5K98_05450	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K5K98_05460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K98_05480	COG0590	tRNA wobble adenosine to inosine editing
K5K98_05485	COG1953	Uracil, thiamine, allantoin
K5K98_05495	COG2508	Transcriptional regulator
K5K98_05505	COG1132	(ABC) transporter
K5K98_05510	COG4988	ABC transporter
K5K98_05520	COG1288	antiporter activity
K5K98_05525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K98_05535	COG1609	Transcriptional regulator
K5K98_05555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5K98_05560	COG0732	type I restriction modification DNA specificity domain
K5K98_05565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5K98_05575	COG4974	Belongs to the 'phage' integrase family
K5K98_05585	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5K98_05590	COG0149	triose-phosphate isomerase activity
K5K98_05595	COG0126	phosphoglycerate kinase activity
K5K98_05605	COG2390	Transcriptional regulator
K5K98_05610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5K98_05620	COG0740	serine-type endopeptidase activity
K5K98_05645	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K98_05650	COG0022	dehydrogenase e1 component
K5K98_05655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K98_05660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K98_05665	COG3284	Transcriptional regulator
K5K98_05670	COG1481	regulation of sporulation
K5K98_05680	COG1660	Displays ATPase and GTPase activities
K5K98_05685	COG2186	Transcriptional regulator
K5K98_05690	COG1131	(ABC) transporter
K5K98_05705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5K98_05710	COG0556	nucleotide-excision repair
K5K98_05715	COG3579	cysteine-type endopeptidase activity
K5K98_05720	COG1316	TRANSCRIPTIONal
K5K98_05725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5K98_05735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5K98_05740	COG2304	oxidoreductase activity
K5K98_05750	COG0714	Associated with various cellular activities
K5K98_05755	COG4716	Myosin-crossreactive antigen
K5K98_05770	COG2608	mercury ion transmembrane transporter activity
K5K98_05775	COG2723	6-phospho-beta-galactosidase activity
K5K98_05780	COG1263	PTS System
K5K98_05780	COG2190	(PTS) system
K5K98_05780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_05785	COG3711	transcriptional antiterminator
K5K98_05795	COG0436	Aminotransferase
K5K98_05805	COG1199	ATP-dependent helicase activity
K5K98_05805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5K98_05815	COG2246	polysaccharide biosynthetic process
K5K98_05865	COG1098	S1 RNA binding domain
K5K98_05870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K98_05875	COG0572	uridine kinase
K5K98_05880	COG4619	ABC transporter
K5K98_05885	COG0390	transport system, permease component
K5K98_05895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K98_05900	COG2188	Transcriptional regulator
K5K98_05905	COG1446	asparaginase
K5K98_05925	COG4608	Belongs to the ABC transporter superfamily
K5K98_05930	COG0444	Belongs to the ABC transporter superfamily
K5K98_05935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K98_05940	COG0601	transmembrane transport
K5K98_05950	COG4166	transmembrane transport
K5K98_05960	COG3716	PTS system mannose fructose sorbose family IID component
K5K98_05965	COG3715	PTS system
K5K98_05975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_05975	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K98_05980	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K98_05980	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K98_05995	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K98_06000	COG4166	transmembrane transport
K5K98_06005	COG4166	transmembrane transport
K5K98_06010	COG4166	transmembrane transport
K5K98_06020	COG4948	Mandelate Racemase Muconate Lactonizing
K5K98_06035	COG2723	6-phospho-beta-galactosidase activity
K5K98_06040	COG0371	Dehydrogenase
K5K98_06045	COG0765	amino acid transport
K5K98_06050	COG1126	abc transporter atp-binding protein
K5K98_06055	COG0436	Aminotransferase
K5K98_06065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K5K98_06070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5K98_06080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K5K98_06085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5K98_06090	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K98_06090	COG3942	CHAP domain
K5K98_06100	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K98_06105	COG2514	catechol 2,3-dioxygenase activity
K5K98_06120	COG2217	Heavy metal translocating P-type atpase
K5K98_06130	COG5002	protein histidine kinase activity
K5K98_06135	COG0745	RESPONSE REGULATOR receiver
K5K98_06140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K98_06145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5K98_06150	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5K98_06160	COG4703	Protein of unknown function (DUF1797)
K5K98_06165	COG2084	Dehydrogenase
K5K98_06175	COG0438	transferase activity, transferring glycosyl groups
K5K98_06180	COG0438	transferase activity, transferring glycosyl groups
K5K98_06185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K98_06200	COG0542	response to heat
K5K98_06215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K98_06225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5K98_06245	COG0463	Glycosyl transferase, family 2
K5K98_06250	COG3328	transposase activity
K5K98_06270	COG1253	flavin adenine dinucleotide binding
K5K98_06275	COG0628	permease
K5K98_06280	COG2153	protein acetylation
K5K98_06290	COG3557	Belongs to the UPF0374 family
K5K98_06295	COG1194	a g-specific adenine glycosylase
K5K98_06300	COG2137	regulation of response to DNA damage stimulus
K5K98_06305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5K98_06310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5K98_06340	COG0589	response to stress
K5K98_06345	COG1316	TRANSCRIPTIONal
K5K98_06360	COG3955	Domain of unknown function (DUF1919)
K5K98_06365	COG5039	Polysaccharide pyruvyl transferase
K5K98_06370	COG1216	Glycosyl transferase, family 2
K5K98_06370	COG1442	glycosyl transferase family 8
K5K98_06395	COG1086	Polysaccharide biosynthesis protein
K5K98_06405	COG1215	transferase activity, transferring glycosyl groups
K5K98_06415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5K98_06425	COG4464	protein tyrosine phosphatase activity
K5K98_06430	COG0489	protein tyrosine kinase activity
K5K98_06440	COG4372	Transposase
K5K98_06455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K98_06460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K98_06465	COG1682	transport, permease protein
K5K98_06470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K5K98_06475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K98_06480	COG1134	teichoic acid transport
K5K98_06485	COG1316	TRANSCRIPTIONal
K5K98_06490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K98_06500	COG1295	ribonuclease BN
K5K98_06505	COG0024	Methionine aminopeptidase
K5K98_06510	COG0716	FMN binding
K5K98_06520	COG2309	aminopeptidase activity
K5K98_06525	COG0726	polysaccharide deacetylase
K5K98_06535	COG5002	protein histidine kinase activity
K5K98_06535	COG3850	Histidine kinase
K5K98_06540	COG0745	RESPONSE REGULATOR receiver
K5K98_06550	COG1316	TRANSCRIPTIONal
K5K98_06815	COG0582	viral genome integration into host DNA
K5K98_06855	COG1396	sequence-specific DNA binding
K5K98_06885	COG1447	Phosphotransferase system cellobiose-specific component IIA
K5K98_06890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_06910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_06920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K98_06920	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K98_06925	COG0513	Belongs to the DEAD box helicase family
K5K98_06935	COG2890	protein-(glutamine-N5) methyltransferase activity
K5K98_06950	COG1132	(ABC) transporter
K5K98_06965	COG2388	GCN5-related N-acetyl-transferase
K5K98_06970	COG5503	Protein of unknown function (DUF1447)
K5K98_06980	COG1278	Cold shock
K5K98_06985	COG2003	Belongs to the UPF0758 family
K5K98_06990	COG0546	phosphoglycolate phosphatase activity
K5K98_06995	COG0285	dihydrofolate synthase activity
K5K98_07000	COG0525	valine-tRNA ligase activity
K5K98_07010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K98_07015	COG0301	tRNA thio-modification
K5K98_07020	COG1104	cysteine desulfurase activity
K5K98_07025	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K5K98_07030	COG0527	aspartate kinase activity
K5K98_07045	COG0561	phosphatase activity
K5K98_07060	COG3594	Acyltransferase
K5K98_07080	COG3091	SprT-like family
K5K98_07085	COG2183	response to ionizing radiation
K5K98_07095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5K98_07110	COG0681	Belongs to the peptidase S26 family
K5K98_07120	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K98_07125	COG1876	peptidase activity
K5K98_07135	COG4129	membrane
K5K98_07150	COG0384	phenazine biosynthesis protein PhzF
K5K98_07160	COG0789	Transcriptional regulator
K5K98_07175	COG2268	Band 7 protein
K5K98_07235	COG0436	Aminotransferase
K5K98_07245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5K98_07260	COG1174	glycine betaine transport
K5K98_07270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5K98_07275	COG3599	regulation of cell shape
K5K98_07280	COG2302	S4 RNA-binding domain
K5K98_07290	COG1799	cell septum assembly
K5K98_07295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5K98_07300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5K98_07305	COG0849	cell division
K5K98_07310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5K98_07315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5K98_07320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5K98_07325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K98_07330	COG0768	penicillin binding
K5K98_07340	COG0275	rRNA processing
K5K98_07345	COG2001	Belongs to the MraZ family
K5K98_07360	COG0497	DNA recombination
K5K98_07365	COG1438	arginine binding
K5K98_07370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K5K98_07380	COG1722	exodeoxyribonuclease VII activity
K5K98_07385	COG1570	exodeoxyribonuclease VII activity
K5K98_07390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5K98_07395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K98_07400	COG1302	Protein conserved in bacteria
K5K98_07405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K98_07410	COG0006	proline dipeptidase activity
K5K98_07415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5K98_07420	COG2868	ribosomal protein
K5K98_07425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5K98_07440	COG4122	O-methyltransferase activity
K5K98_07445	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K5K98_07450	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K5K98_07455	COG0222	ribosome binding
K5K98_07460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5K98_07465	COG0081	regulation of translation
K5K98_07470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5K98_07485	COG2217	Heavy metal translocating P-type atpase
K5K98_07490	COG0673	inositol 2-dehydrogenase activity
K5K98_07510	COG0673	inositol 2-dehydrogenase activity
K5K98_07520	COG1418	mRNA catabolic process
K5K98_07525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5K98_07530	COG1058	Belongs to the CinA family
K5K98_07530	COG1546	Belongs to the CinA family
K5K98_07535	COG1760	l-serine dehydratase
K5K98_07540	COG1760	l-serine dehydratase
K5K98_07555	COG1757	Na H antiporter
K5K98_07565	COG0250	Participates in transcription elongation, termination and antitermination
K5K98_07575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K98_07590	COG0456	acetyltransferase
K5K98_07595	COG0431	NADPH-dependent FMN reductase
K5K98_07600	COG1597	lipid kinase activity
K5K98_07615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5K98_07620	COG0406	alpha-ribazole phosphatase activity
K5K98_07625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5K98_07630	COG0500	methyltransferase
K5K98_07635	COG3142	Participates in the control of copper homeostasis
K5K98_07655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K98_07660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K98_07665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K98_07670	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K98_07670	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5K98_07675	COG0626	cystathionine gamma-synthase activity
K5K98_07680	COG0251	oxidation-reduction process
K5K98_07685	COG0842	Transport permease protein
K5K98_07690	COG1131	(ABC) transporter
K5K98_07700	COG0456	acetyltransferase
K5K98_07705	COG2239	Acts as a magnesium transporter
K5K98_07710	COG0564	pseudouridine synthase activity
K5K98_07715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5K98_07720	COG2357	RelA SpoT domain protein
K5K98_07725	COG4116	CYTH
K5K98_07730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5K98_07735	COG1164	Oligoendopeptidase f
K5K98_07745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5K98_07750	COG0488	(ABC) transporter
K5K98_07755	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K98_07770	COG0459	protein refolding
K5K98_07780	COG0783	Belongs to the Dps family
K5K98_07785	COG0693	protein deglycase activity
K5K98_07810	COG1454	alcohol dehydrogenase
K5K98_07810	COG1012	belongs to the aldehyde dehydrogenase family
K5K98_07815	COG2610	gluconate transmembrane transporter activity
K5K98_07820	COG1028	Short-chain dehydrogenase reductase Sdr
K5K98_07825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5K98_07830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K5K98_07840	COG0583	DNA-binding transcription factor activity
K5K98_07845	COG2030	dehydratase
K5K98_07850	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K98_07855	COG4670	ketone body catabolic process
K5K98_07860	COG0583	DNA-binding transcription factor activity
K5K98_07880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5K98_07885	COG4109	DRTGG domain
K5K98_07890	COG2814	Major facilitator Superfamily
K5K98_07900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K98_07905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5K98_07910	COG4720	Psort location CytoplasmicMembrane, score
K5K98_07915	COG1132	(ABC) transporter
K5K98_07920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5K98_07925	COG0419	ATPase involved in DNA repair
K5K98_07930	COG0420	3'-5' exonuclease activity
K5K98_07935	COG1309	transcriptional regulator
K5K98_07945	COG1131	(ABC) transporter
K5K98_07950	COG0204	Acyl-transferase
K5K98_07955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5K98_07960	COG2827	Endonuclease containing a URI domain
K5K98_07965	COG2226	methyltransferase
K5K98_07970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K98_07975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5K98_07980	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5K98_07990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K98_08010	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K98_08020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5K98_08025	COG0640	Transcriptional regulator
K5K98_08035	COG3878	Protein conserved in bacteria
K5K98_08045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5K98_08050	COG2264	protein methyltransferase activity
K5K98_08060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5K98_08080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5K98_08085	COG0827	DNA restriction-modification system
K5K98_08115	COG4537	Required for transformation and DNA binding
K5K98_08125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5K98_08135	COG0217	transcriptional regulatory protein
K5K98_08165	COG1792	Involved in formation and maintenance of cell shape
K5K98_08170	COG1012	belongs to the aldehyde dehydrogenase family
K5K98_08170	COG1454	alcohol dehydrogenase
K5K98_08185	COG0343	queuine tRNA-ribosyltransferase activity
K5K98_08190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5K98_08195	COG2255	four-way junction helicase activity
K5K98_08210	COG0424	maF-like protein
K5K98_08215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5K98_08220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K98_08230	COG1692	metallophosphoesterase
K5K98_08245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5K98_08250	COG4684	Psort location CytoplasmicMembrane, score
K5K98_08270	COG3859	Proton-coupled thiamine transporter YuaJ
K5K98_08280	COG1309	transcriptional regulator
K5K98_08295	COG1388	LysM domain
K5K98_08295	COG3584	3D domain protein
K5K98_08305	COG1132	(ABC) transporter
K5K98_08310	COG1132	(ABC) transporter
K5K98_08330	COG1011	Hydrolase
K5K98_08335	COG0789	Transcriptional regulator
K5K98_08350	COG1803	Methylglyoxal synthase
K5K98_08355	COG3842	ATPase activity
K5K98_08370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5K98_08375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K5K98_08380	COG0084	hydrolase, TatD family'
K5K98_08385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K98_08385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K98_08395	COG1914	H( )-stimulated, divalent metal cation uptake system
K5K98_08405	COG2207	Transcriptional regulator
K5K98_08405	COG3708	Transcriptional regulator
K5K98_08410	COG0456	acetyltransferase
K5K98_08415	COG1418	mRNA catabolic process
K5K98_08420	COG0366	Alpha amylase catalytic
K5K98_08425	COG1263	PTS System
K5K98_08425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_08430	COG2188	Transcriptional regulator
K5K98_08435	COG0415	Belongs to the DNA photolyase family
K5K98_08440	COG1737	Transcriptional regulator
K5K98_08460	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K5K98_08465	COG2723	6-phospho-beta-galactosidase activity
K5K98_08475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_08485	COG1053	succinate dehydrogenase
K5K98_08485	COG3976	FMN-binding domain protein
K5K98_08490	COG4607	ABC-type enterochelin transport system periplasmic component
K5K98_08495	COG4604	ABC transporter, ATP-binding protein
K5K98_08500	COG4605	iron ion homeostasis
K5K98_08505	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5K98_08510	COG5506	Protein of unknown function (DUF1694)
K5K98_08515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5K98_08555	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K98_08555	COG2918	glutathione biosynthetic process
K5K98_08560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K98_08560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K98_08560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K98_08565	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K98_08570	COG1349	DNA-binding transcription factor activity
K5K98_08575	COG0552	protein localization to endoplasmic reticulum
K5K98_08580	COG0561	phosphatase activity
K5K98_08585	COG1196	nuclear chromosome segregation
K5K98_08590	COG0571	ribonuclease III activity
K5K98_08595	COG0747	negative chemotaxis
K5K98_08600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K98_08610	COG4608	Belongs to the ABC transporter superfamily
K5K98_08620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K98_08625	COG0416	fatty acid biosynthetic process
K5K98_08630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5K98_08635	COG1461	Dihydroxyacetone kinase
K5K98_08645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5K98_08650	COG1564	THIamine pyrophosphokinase
K5K98_08655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5K98_08660	COG1162	GTPase activity
K5K98_08665	COG2815	serine threonine protein kinase
K5K98_08665	COG0515	serine threonine protein kinase
K5K98_08675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5K98_08675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K98_08680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5K98_08685	COG0242	peptide deformylase activity
K5K98_08690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5K98_08705	COG0384	phenazine biosynthesis protein PhzF
K5K98_08715	COG0194	GDP metabolic process
K5K98_08720	COG1561	YicC-like family, N-terminal region
K5K98_08740	COG0736	holo-[acyl-carrier-protein] synthase activity
K5K98_08750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K98_08755	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K98_08765	COG3764	Sortase (surface protein transpeptidase)
K5K98_08770	COG3481	metal-dependent phosphohydrolase, HD sub domain
K5K98_08775	COG4717	serine-type aminopeptidase activity
K5K98_08785	COG3679	Belongs to the UPF0342 family
K5K98_08790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K98_08795	COG0564	pseudouridine synthase activity
K5K98_08820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K98_08835	COG1438	arginine binding
K5K98_08840	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K98_08850	COG2207	Transcriptional regulator
K5K98_08855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K98_08875	COG2814	Major facilitator Superfamily
K5K98_08885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K98_08900	COG0456	acetyltransferase
K5K98_08900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K5K98_08910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K98_08935	COG3279	Response regulator of the LytR AlgR family
K5K98_08945	COG4166	transmembrane transport
K5K98_08955	COG1247	-acetyltransferase
K5K98_08965	COG0110	maltose O-acetyltransferase activity
K5K98_08975	COG0427	acetyl-CoA hydrolase
K5K98_08980	COG1024	Enoyl-CoA hydratase
K5K98_08985	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K98_08990	COG0183	Belongs to the thiolase family
K5K98_08995	COG0583	DNA-binding transcription factor activity
K5K98_09000	COG1960	acyl-CoA dehydrogenase activity
K5K98_09015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K98_09020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K98_09030	COG2323	membrane
K5K98_09040	COG2723	6-phospho-beta-galactosidase activity
K5K98_09045	COG1737	Transcriptional regulator
K5K98_09055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_09060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K98_09115	COG0400	carboxylic ester hydrolase activity
K5K98_09120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5K98_09125	COG0346	lactoylglutathione lyase activity
K5K98_09130	COG0346	lactoylglutathione lyase activity
K5K98_09135	COG1846	Transcriptional regulator
K5K98_09165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5K98_09170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K5K98_09175	COG1024	Enoyl-CoA hydratase
K5K98_09180	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K98_09185	COG0183	Belongs to the thiolase family
K5K98_09190	COG0583	DNA-binding transcription factor activity
K5K98_09200	COG0346	lactoylglutathione lyase activity
K5K98_09205	COG1263	PTS System
K5K98_09205	COG2190	(PTS) system
K5K98_09205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_09210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5K98_09215	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5K98_09220	COG1486	melibiose metabolic process
K5K98_09225	COG1263	PTS System
K5K98_09225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_09240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K98_09255	COG1304	FMN binding
K5K98_09260	COG1346	cytolysis
K5K98_09265	COG1380	Effector of murein hydrolase LrgA
K5K98_09280	COG1054	Belongs to the UPF0176 family
K5K98_09290	COG0604	alcohol dehydrogenase
K5K98_09300	COG0656	L-ascorbic acid biosynthetic process
K5K98_09305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K98_09330	COG0494	nUDIX hydrolase
K5K98_09345	COG0475	glutathione-regulated potassium exporter activity
K5K98_09380	COG3759	membrane
K5K98_09385	COG0778	Nitroreductase
K5K98_09390	COG1846	Transcriptional regulator
K5K98_09400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5K98_09405	COG3959	Transketolase, thiamine diphosphate binding domain
K5K98_09420	COG3711	transcriptional antiterminator
K5K98_09425	COG1011	Hydrolase
K5K98_09430	COG0402	S-adenosylhomocysteine deaminase activity
K5K98_09435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5K98_09460	COG1309	transcriptional regulator
K5K98_09470	COG0346	lactoylglutathione lyase activity
K5K98_09495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5K98_09500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5K98_09515	COG1122	ATPase activity
K5K98_09520	COG1122	ATPase activity
K5K98_09525	COG0203	ribosomal protein L17
K5K98_09530	COG0202	RNA polymerase activity
K5K98_09535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5K98_09540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5K98_09545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5K98_09550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5K98_09555	COG0563	adenylate kinase activity
K5K98_09565	COG0200	Binds to the 23S rRNA
K5K98_09570	COG1841	ribosomal large subunit assembly
K5K98_09575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5K98_09585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5K98_09590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5K98_09595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K98_09600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5K98_09605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5K98_09610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5K98_09615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5K98_09620	COG0255	Belongs to the universal ribosomal protein uL29 family
K5K98_09625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5K98_09630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5K98_09635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5K98_09640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5K98_09645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5K98_09650	COG0089	rRNA binding
K5K98_09655	COG0088	Forms part of the polypeptide exit tunnel
K5K98_09660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5K98_09665	COG0051	transcription antitermination factor activity, RNA binding
K5K98_09675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5K98_09680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5K98_09685	COG0049	tRNA binding
K5K98_09690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5K98_09695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5K98_09700	COG0588	phosphoglycerate mutase activity
K5K98_09710	COG1114	Component of the transport system for branched-chain amino acids
K5K98_09875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5K98_09885	COG0516	GMP reductase activity
K5K98_09885	COG0517	IMP dehydrogenase activity
K5K98_09895	COG0012	GTP binding
K5K98_09900	COG4481	Protein conserved in bacteria
K5K98_09905	COG1475	DNA binding
K5K98_09910	COG1192	Involved in chromosome partitioning
K5K98_09915	COG0357	Ribosomal RNA small subunit methyltransferase G
K5K98_09930	COG0445	tRNA wobble uridine modification
K5K98_09935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5K98_09945	COG1438	arginine binding
K5K98_09960	COG2153	protein acetylation
K5K98_09965	COG0018	arginyl-trna synthetase
K5K98_09970	COG1288	antiporter activity
K5K98_09980	COG0549	Belongs to the carbamate kinase family
K5K98_09985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5K98_09990	COG2235	arginine
K5K98_09995	COG1438	arginine binding
K5K98_10005	COG0706	membrane insertase activity
K5K98_10010	COG0594	ribonuclease P activity
K5K98_10015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5K98_10020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5K98_10025	COG0592	DNA-directed DNA polymerase activity
K5K98_10035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5K98_10040	COG0187	DNA topoisomerase II activity
K5K98_10050	COG0360	Binds together with S18 to 16S ribosomal RNA
K5K98_10055	COG0629	single-stranded DNA binding
K5K98_10060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5K98_10065	COG0359	binds to the 23S rRNA
K5K98_10070	COG0305	Participates in initiation and elongation during chromosome replication
K5K98_10075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5K98_10095	COG0488	(ABC) transporter
K5K98_10105	COG0142	geranyltranstransferase activity
K5K98_10120	COG4939	FMN-binding domain protein
K5K98_10140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5K98_10155	COG1609	Transcriptional regulator
K5K98_10160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5K98_10170	COG1744	ABC transporter substrate-binding protein PnrA-like
K5K98_10175	COG3845	ABC transporter
K5K98_10180	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5K98_10185	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5K98_10190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5K98_10200	COG0813	purine-nucleoside phosphorylase activity
K5K98_10220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5K98_10225	COG0477	Major facilitator Superfamily
K5K98_10240	COG1686	Belongs to the peptidase S11 family
K5K98_10245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K5K98_10250	COG1242	4 iron, 4 sulfur cluster binding
K5K98_10255	COG0671	phosphoesterase, PA-phosphatase related
K5K98_10270	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K98_10270	COG1388	LysM domain
K5K98_10275	COG0495	leucyl-tRNA aminoacylation
K5K98_10280	COG2244	polysaccharide biosynthetic process
K5K98_10285	COG1187	pseudouridine synthase activity
K5K98_10290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K98_10315	COG1126	abc transporter atp-binding protein
K5K98_10320	COG0765	amino acid transport
K5K98_10330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5K98_10345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5K98_10355	COG1653	transport
K5K98_10360	COG1175	transmembrane transport
K5K98_10365	COG0395	ABC-type sugar transport system, permease component
K5K98_10370	COG3842	ATPase activity
K5K98_10390	COG5294	Protein conserved in bacteria
K5K98_10435	COG1396	sequence-specific DNA binding
K5K98_10440	COG3620	sequence-specific DNA binding
K5K98_10450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K98_10455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K98_10480	COG4808	Protein conserved in bacteria
K5K98_10485	COG1733	regulation of RNA biosynthetic process
K5K98_10495	COG1278	Cold shock
K5K98_10505	COG0686	Belongs to the AlaDH PNT family
K5K98_10510	COG1764	response to oxidative stress
K5K98_10535	COG1461	Dihydroxyacetone kinase
K5K98_10545	COG3328	transposase activity
K5K98_10570	COG0659	secondary active sulfate transmembrane transporter activity
K5K98_10575	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K98_10585	COG1269	ATP hydrolysis coupled proton transport
K5K98_10590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K98_10600	COG1527	subunit (C
K5K98_10605	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
K5K98_10610	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5K98_10615	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K5K98_10620	COG1394	ATPase activity, coupled to movement of substances
K5K98_10630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5K98_10635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5K98_10660	COG1733	regulation of RNA biosynthetic process
K5K98_10720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5K98_10730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K98_10740	COG0039	L-malate dehydrogenase activity
K5K98_10745	COG0193	aminoacyl-tRNA hydrolase activity
K5K98_10750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5K98_10755	COG2244	polysaccharide biosynthetic process
K5K98_10760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5K98_10770	COG1098	S1 RNA binding domain
K5K98_10775	COG0037	tRNA processing
K5K98_10780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5K98_10785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5K98_10790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5K98_10795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K98_10800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5K98_10980	COG4463	regulation of RNA biosynthetic process
K5K98_10985	COG0542	response to heat
K5K98_10995	COG0826	peptidase U32
K5K98_11000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K98_11005	COG1271	oxidase subunit
K5K98_11010	COG1294	oxidase, subunit
K5K98_11015	COG4988	ABC transporter
K5K98_11020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5K98_11035	COG1054	Belongs to the UPF0176 family
K5K98_11085	COG0363	glucosamine-6-phosphate deaminase activity
K5K98_11090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K98_11120	COG0798	PFAM Bile acid sodium symporter
K5K98_11175	COG1442	glycosyl transferase family 8
K5K98_11200	COG0640	Transcriptional regulator
K5K98_11205	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K98_11235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K98_11245	COG1609	Transcriptional regulator
K5K98_11255	COG0488	(ABC) transporter
K5K98_11265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5K98_11275	COG0628	permease
K5K98_11290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5K98_11295	COG1426	Protein conserved in bacteria
K5K98_11300	COG0300	oxidoreductase activity
K5K98_11305	COG0612	Peptidase, M16
K5K98_11310	COG0612	Peptidase, M16
K5K98_11315	COG1970	mechanosensitive ion channel activity
K5K98_11320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5K98_11330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K98_11335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K98_11340	COG1121	(ABC) transporter
K5K98_11345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5K98_11355	COG1177	transmembrane transport
K5K98_11360	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5K98_11365	COG3842	ATPase activity
K5K98_11375	COG0604	alcohol dehydrogenase
K5K98_11430	COG1473	amidohydrolase
K5K98_11435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5K98_11440	COG0038	chloride channel
K5K98_11450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K98_11460	COG3290	protein histidine kinase activity
K5K98_11465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5K98_11470	COG0708	Exodeoxyribonuclease III
K5K98_11490	COG0802	atpase or kinase
K5K98_11500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K98_11510	COG1263	PTS System
K5K98_11510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_11510	COG2190	(PTS) system
K5K98_11520	COG1609	Transcriptional regulator
K5K98_11530	COG0280	phosphate acetyltransferase
K5K98_11540	COG0561	phosphatase activity
K5K98_11550	COG0025	NhaP-type Na H and K H
K5K98_11555	COG1278	Cold shock
K5K98_11575	COG0745	RESPONSE REGULATOR receiver
K5K98_11580	COG5002	protein histidine kinase activity
K5K98_11585	COG2433	Pfam Transposase IS66
K5K98_11610	COG1131	(ABC) transporter
K5K98_11655	COG1215	transferase activity, transferring glycosyl groups
K5K98_11665	COG2188	Transcriptional regulator
K5K98_11690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5K98_11715	COG2217	Heavy metal translocating P-type atpase
K5K98_11720	COG1285	pathogenesis
K5K98_11725	COG0251	oxidation-reduction process
K5K98_11745	COG2390	Transcriptional regulator
K5K98_11750	COG0583	DNA-binding transcription factor activity
K5K98_11755	COG4166	transmembrane transport
K5K98_11760	COG0402	S-adenosylhomocysteine deaminase activity
K5K98_11765	COG0402	S-adenosylhomocysteine deaminase activity
K5K98_11790	COG4869	propanediol catabolic process
K5K98_11800	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
K5K98_11810	COG1129	ABC transporter
K5K98_11815	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5K98_11825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5K98_11830	COG1349	DNA-binding transcription factor activity
K5K98_11835	COG0235	Class ii aldolase
K5K98_11850	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K5K98_11860	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K98_11870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5K98_11880	COG4335	DNA alkylation repair
K5K98_11910	COG3448	diguanylate cyclase activity
K5K98_11910	COG4175	Glycine betaine
K5K98_11945	COG1132	(ABC) transporter
K5K98_11950	COG1132	(ABC) transporter
K5K98_11955	COG0765	amino acid transport
K5K98_11960	COG1126	abc transporter atp-binding protein
K5K98_11965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5K98_11975	COG0435	Glutathione S-transferase
K5K98_11985	COG3022	response to hydroperoxide
K5K98_11990	COG2252	PERMEase
K5K98_12010	COG5504	Zn-dependent protease
K5K98_12015	COG2723	6-phospho-beta-galactosidase activity
K5K98_12020	COG1940	carbohydrate kinase activity
K5K98_12030	COG3973	AAA domain
K5K98_12050	COG0531	amino acid
K5K98_12060	COG1757	Na H antiporter
K5K98_12080	COG4166	transmembrane transport
K5K98_12095	COG1136	(ABC) transporter
K5K98_12110	COG4372	Transposase
K5K98_12120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K98_12130	COG3037	sugar-specific permease SgaT UlaA
K5K98_12135	COG4821	SIS domain
K5K98_12160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K98_12165	COG1061	Type III restriction enzyme res subunit
K5K98_12170	COG1002	Type II restriction enzyme, methylase subunits
K5K98_12180	COG0519	Catalyzes the synthesis of GMP from XMP
K5K98_12180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5K98_12185	COG1072	(Pantothenic acid kinase))
K5K98_12190	COG2755	lipolytic protein G-D-S-L family
K5K98_12195	COG2813	Specifically methylates the guanine in position
K5K98_12200	COG0085	RNA polymerase activity
K5K98_12205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5K98_12220	COG3711	transcriptional antiterminator
K5K98_12225	COG1263	PTS System
K5K98_12225	COG2190	(PTS) system
K5K98_12225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_12230	COG2723	6-phospho-beta-galactosidase activity
K5K98_12245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5K98_12250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5K98_12260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5K98_12270	COG3328	transposase activity
K5K98_12275	COG3158	transport of potassium into the cell
K5K98_12280	COG0756	dUTP diphosphatase activity
K5K98_12290	COG4956	integral membrane protein (PIN domain superfamily)
K5K98_12295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5K98_12300	COG1045	serine acetyltransferase
K5K98_12305	COG0215	cysteine-tRNA ligase activity
K5K98_12310	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K5K98_12315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K98_12320	COG3688	RNA-binding protein containing a PIN domain
K5K98_12330	COG4466	Protein conserved in bacteria
K5K98_12335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5K98_12340	COG4980	gas vesicle protein
K5K98_12345	COG0537	adenosine 5'-monophosphoramidase activity
K5K98_12350	COG1131	(ABC) transporter
K5K98_12355	COG4473	ABC transporter
K5K98_12360	COG0510	thiamine kinase activity
K5K98_12365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5K98_12370	COG1611	Belongs to the LOG family
K5K98_12375	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K98_12385	COG1363	Peptidase, m42
K5K98_12390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K98_12400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K98_12405	COG4472	Bacterial protein of unknown function (DUF965)
K5K98_12410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5K98_12425	COG3906	Belongs to the UPF0473 family
K5K98_12430	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K98_12445	COG1193	negative regulation of DNA recombination
K5K98_12450	COG3118	belongs to the thioredoxin family
K5K98_12455	COG0322	excinuclease ABC activity
K5K98_12480	COG4152	abc transporter atp-binding protein
K5K98_12485	COG1668	transmembrane transport
K5K98_12510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5K98_12515	COG2116	formate transmembrane transporter activity
K5K98_12520	COG0561	phosphatase activity
K5K98_12525	COG0242	peptide deformylase activity
K5K98_12530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5K98_12535	COG1185	polyribonucleotide nucleotidyltransferase activity
K5K98_12550	COG0383	alpha-mannosidase activity
K5K98_12560	COG1609	Transcriptional regulator
K5K98_12570	COG1940	carbohydrate kinase activity
K5K98_12580	COG1649	PFAM Uncharacterised BCR, COG1649
K5K98_12600	COG1309	transcriptional regulator
K5K98_12605	COG2376	Dihydroxyacetone kinase
K5K98_12610	COG1461	Dihydroxyacetone kinase
K5K98_12615	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K5K98_12620	COG0371	Dehydrogenase
K5K98_12625	COG2376	Dihydroxyacetone kinase
K5K98_12650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5K98_12655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5K98_12660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5K98_12665	COG0028	Belongs to the TPP enzyme family
K5K98_12675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K98_12680	COG2011	ABC-type metal ion transport system permease component
K5K98_12715	COG0642	Histidine kinase
K5K98_12725	COG1136	(ABC) transporter
K5K98_12730	COG0577	efflux transmembrane transporter activity
K5K98_12735	COG1363	Peptidase, m42
K5K98_12750	COG0577	efflux transmembrane transporter activity
K5K98_12755	COG1234	tRNA 3'-trailer cleavage
K5K98_12760	COG0095	Lipoate-protein ligase
K5K98_12765	COG0740	serine-type endopeptidase activity
K5K98_12770	COG0180	Tryptophanyl-tRNA synthetase
K5K98_12775	COG1393	Belongs to the ArsC family
K5K98_12780	COG4862	establishment of competence for transformation
K5K98_12790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K98_12795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K98_12800	COG1780	Probably involved in ribonucleotide reductase function
K5K98_12805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5K98_12825	COG0745	RESPONSE REGULATOR receiver
K5K98_12830	COG5002	protein histidine kinase activity
K5K98_12845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5K98_12850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5K98_12855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5K98_12860	COG1160	GTP binding
K5K98_12905	COG2267	carboxylic ester hydrolase activity
K5K98_12915	COG1573	uracil-dna glycosylase
K5K98_12930	COG1131	(ABC) transporter
K5K98_12950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K5K98_12955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K98_12960	COG2169	Transcriptional regulator
K5K98_12965	COG4166	transmembrane transport
K5K98_12980	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5K98_12985	COG1175	transmembrane transport
K5K98_12990	COG0395	ABC-type sugar transport system, permease component
K5K98_13010	COG1737	Transcriptional regulator
K5K98_13015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K98_13020	COG4166	transmembrane transport
K5K98_13030	COG0673	inositol 2-dehydrogenase activity
K5K98_13040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K98_13050	COG1737	Transcriptional regulator
K5K98_13055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_13060	COG2723	6-phospho-beta-galactosidase activity
K5K98_13065	COG1940	carbohydrate kinase activity
K5K98_13070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_13075	COG2188	Transcriptional regulator
K5K98_13080	COG2723	6-phospho-beta-galactosidase activity
K5K98_13095	COG0789	Transcriptional regulator
K5K98_13100	COG0667	Aldo Keto reductase
K5K98_13105	COG1846	Transcriptional regulator
K5K98_13110	COG2814	Major facilitator Superfamily
K5K98_13115	COG1132	(ABC) transporter
K5K98_13130	COG0745	RESPONSE REGULATOR receiver
K5K98_13135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K5K98_13145	COG5002	protein histidine kinase activity
K5K98_13150	COG0745	RESPONSE REGULATOR receiver
K5K98_13155	COG0577	efflux transmembrane transporter activity
K5K98_13160	COG1136	(ABC) transporter
K5K98_13165	COG1187	pseudouridine synthase activity
K5K98_13170	COG0217	transcriptional regulatory protein
K5K98_13180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K98_13195	COG1132	(ABC) transporter
K5K98_13200	COG1132	(ABC) transporter
K5K98_13210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5K98_13245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5K98_13265	COG0395	ABC-type sugar transport system, permease component
K5K98_13270	COG1175	transmembrane transport
K5K98_13280	COG0564	pseudouridine synthase activity
K5K98_13285	COG4684	Psort location CytoplasmicMembrane, score
K5K98_13305	COG3730	PTS system glucitol sorbitol-specific
K5K98_13310	COG3732	PTS system glucitol sorbitol-specific
K5K98_13325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K98_13335	COG0604	alcohol dehydrogenase
K5K98_13355	COG2169	Transcriptional regulator
K5K98_13365	COG0698	ribose 5-phosphate isomerase
K5K98_13380	COG3775	system Galactitol-specific IIC component
K5K98_13385	COG0235	Class ii aldolase
K5K98_13390	COG3414	Phosphotransferase system galactitol-specific IIB component
K5K98_13395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K98_13400	COG0022	dehydrogenase e1 component
K5K98_13430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5K98_13440	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K5K98_13445	COG0352	thiamine-phosphate diphosphorylase activity
K5K98_13450	COG0351	phosphomethylpyrimidine kinase
K5K98_13455	COG0531	amino acid
K5K98_13460	COG0662	Cupin 2, conserved barrel domain protein
K5K98_13490	COG3639	organic phosphonate transmembrane transporter activity
K5K98_13495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K5K98_13515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K98_13530	COG0159	tryptophan synthase activity
K5K98_13545	COG0513	Belongs to the DEAD box helicase family
K5K98_13550	COG0105	UTP biosynthetic process
K5K98_13570	COG0431	NADPH-dependent FMN reductase
K5K98_13570	COG3976	FMN-binding domain protein
K5K98_13570	COG1053	succinate dehydrogenase
K5K98_13595	COG1305	Transglutaminase-like
K5K98_13605	COG1609	Transcriptional regulator
K5K98_13615	COG1869	D-ribose catabolic process
K5K98_13620	COG4975	Glucose uptake
K5K98_13655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_13655	COG1263	PTS System
K5K98_13655	COG2190	(PTS) system
K5K98_13660	COG3711	transcriptional antiterminator
K5K98_13665	COG2213	PTS system mannitol-specific
K5K98_13670	COG3711	transcriptional antiterminator
K5K98_13675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K98_13680	COG2213	PTS system mannitol-specific
K5K98_13685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K98_13690	COG0246	Mannitol dehydrogenase
K5K98_13735	COG0745	RESPONSE REGULATOR receiver
K5K98_13745	COG0367	asparagine synthase
K5K98_13765	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K5K98_13775	COG1506	peptidase
K5K98_13775	COG4946	Tricorn protease homolog
K5K98_13775	COG0823	Involved in the tonB-independent uptake of proteins
K5K98_13785	COG1126	abc transporter atp-binding protein
K5K98_13790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K98_13795	COG0765	amino acid transport
K5K98_13800	COG0765	amino acid transport
K5K98_13810	COG1268	BioY protein
K5K98_13825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K98_13830	COG2011	ABC-type metal ion transport system permease component
K5K98_13835	COG1464	Belongs to the NlpA lipoprotein family
K5K98_13845	COG1486	melibiose metabolic process
K5K98_13850	COG1609	Transcriptional regulator
K5K98_13865	COG3404	Formiminotransferase-cyclodeaminase
K5K98_13870	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K5K98_13880	COG0531	amino acid
K5K98_13890	COG0124	histidyl-tRNA synthetase
K5K98_13895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K98_13900	COG0456	acetyltransferase
K5K98_13905	COG1597	lipid kinase activity
K5K98_13910	COG1228	amidohydrolase
K5K98_13915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5K98_13940	COG1070	Carbohydrate kinase
K5K98_13945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5K98_13950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K98_13955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5K98_13970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5K98_13975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K98_13985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K98_13995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5K98_14000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5K98_14005	COG0138	bifunctional purine biosynthesis protein purh
K5K98_14020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K98_14025	COG1534	Rna-binding protein
K5K98_14030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5K98_14040	COG0799	negative regulation of ribosome biogenesis
K5K98_14045	COG2226	methyltransferase
K5K98_14050	COG1323	Belongs to the UPF0348 family
K5K98_14070	COG3655	Transcriptional regulator
K5K98_14080	COG1304	FMN binding
K5K98_14095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5K98_14100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5K98_14105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K98_14120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5K98_14125	COG1121	(ABC) transporter
K5K98_14130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K98_14145	COG0300	oxidoreductase activity
K5K98_14155	COG0772	Belongs to the SEDS family
K5K98_14165	COG1393	Belongs to the ArsC family
K5K98_14170	COG0509	glycine decarboxylation via glycine cleavage system
K5K98_14175	COG0716	FMN binding
K5K98_14185	COG3706	GGDEF domain
K5K98_14195	COG2738	Putative neutral zinc metallopeptidase
K5K98_14200	COG2508	Transcriptional regulator
K5K98_14205	COG0590	tRNA wobble adenosine to inosine editing
K5K98_14215	COG1428	Deoxynucleoside kinase
K5K98_14240	COG1653	transport
K5K98_14245	COG1175	transmembrane transport
K5K98_14250	COG0395	ABC-type sugar transport system, permease component
K5K98_14255	COG0587	DNA-directed DNA polymerase activity
K5K98_14340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5K98_14400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5K98_14405	COG1780	Probably involved in ribonucleotide reductase function
K5K98_14410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K98_14415	COG1328	CTP reductase activity
K5K98_14425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K98_14445	COG0582	viral genome integration into host DNA
K5K98_14625	COG4373	Mu-like prophage FluMu protein gp28
K5K98_14675	COG0210	DNA helicase
K5K98_14820	COG0492	ferredoxin-NADP+ reductase activity
K5K98_14825	COG2337	Toxic component of a toxin-antitoxin (TA) module
K5K98_15005	COG0328	RNA-DNA hybrid ribonuclease activity
K5K98_15015	COG2176	DNA-directed DNA polymerase activity
K5K98_15125	COG1192	Involved in chromosome partitioning
K5K98_15170	COG2190	(PTS) system
K5K98_15170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K98_15170	COG1263	PTS System
K5K98_15175	COG1737	Transcriptional regulator
K5K98_15180	COG1486	melibiose metabolic process
K5K98_15185	COG1263	PTS System
K5K98_15185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity