locus-tag	class	description
K5K99_00060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5K99_00105	COG0582	viral genome integration into host DNA
K5K99_00110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K99_00125	COG0456	acetyltransferase
K5K99_00130	COG0431	NADPH-dependent FMN reductase
K5K99_00135	COG1597	lipid kinase activity
K5K99_00140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5K99_00145	COG0406	alpha-ribazole phosphatase activity
K5K99_00150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5K99_00155	COG0500	methyltransferase
K5K99_00160	COG3142	Participates in the control of copper homeostasis
K5K99_00180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K99_00185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K99_00190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K99_00195	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K99_00195	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5K99_00200	COG0626	cystathionine gamma-synthase activity
K5K99_00205	COG0251	oxidation-reduction process
K5K99_00210	COG0842	Transport permease protein
K5K99_00215	COG1131	(ABC) transporter
K5K99_00235	COG2239	Acts as a magnesium transporter
K5K99_00240	COG0564	pseudouridine synthase activity
K5K99_00245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5K99_00250	COG2357	RelA SpoT domain protein
K5K99_00255	COG4116	CYTH
K5K99_00260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5K99_00265	COG1164	Oligoendopeptidase f
K5K99_00275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5K99_00280	COG0488	(ABC) transporter
K5K99_00285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K99_00300	COG0459	protein refolding
K5K99_00310	COG0783	Belongs to the Dps family
K5K99_00315	COG0693	protein deglycase activity
K5K99_00335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5K99_00350	COG0183	Belongs to the thiolase family
K5K99_00355	COG1028	Short-chain dehydrogenase reductase Sdr
K5K99_00360	COG0583	DNA-binding transcription factor activity
K5K99_00370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K99_00375	COG4670	ketone body catabolic process
K5K99_00380	COG0583	DNA-binding transcription factor activity
K5K99_00395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5K99_00400	COG4109	DRTGG domain
K5K99_00405	COG2814	Major facilitator Superfamily
K5K99_00415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K99_00420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5K99_00425	COG4720	Psort location CytoplasmicMembrane, score
K5K99_00430	COG1132	(ABC) transporter
K5K99_00435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5K99_00440	COG0419	ATPase involved in DNA repair
K5K99_00445	COG0420	3'-5' exonuclease activity
K5K99_00450	COG1309	transcriptional regulator
K5K99_00460	COG1131	(ABC) transporter
K5K99_00465	COG0204	Acyl-transferase
K5K99_00470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5K99_00475	COG2827	Endonuclease containing a URI domain
K5K99_00485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_00490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5K99_00495	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5K99_00510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K99_00530	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_00540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5K99_00545	COG0640	Transcriptional regulator
K5K99_00555	COG3878	Protein conserved in bacteria
K5K99_00560	COG2357	RelA SpoT domain protein
K5K99_00565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5K99_00570	COG2264	protein methyltransferase activity
K5K99_00580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5K99_00600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5K99_00605	COG0827	DNA restriction-modification system
K5K99_00635	COG4537	Required for transformation and DNA binding
K5K99_00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5K99_00655	COG0217	transcriptional regulatory protein
K5K99_00685	COG1792	Involved in formation and maintenance of cell shape
K5K99_00690	COG1012	belongs to the aldehyde dehydrogenase family
K5K99_00690	COG1454	alcohol dehydrogenase
K5K99_00705	COG0343	queuine tRNA-ribosyltransferase activity
K5K99_00710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5K99_00715	COG2255	four-way junction helicase activity
K5K99_00730	COG0424	maF-like protein
K5K99_00735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5K99_00740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K99_00750	COG1692	metallophosphoesterase
K5K99_00765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5K99_00770	COG4684	Psort location CytoplasmicMembrane, score
K5K99_00795	COG3859	Proton-coupled thiamine transporter YuaJ
K5K99_00805	COG1309	transcriptional regulator
K5K99_00820	COG1388	LysM domain
K5K99_00820	COG3584	3D domain protein
K5K99_00830	COG1132	(ABC) transporter
K5K99_00835	COG1132	(ABC) transporter
K5K99_00850	COG1011	Hydrolase
K5K99_00855	COG0789	Transcriptional regulator
K5K99_00860	COG4221	oxidoreductase activity
K5K99_00870	COG1803	Methylglyoxal synthase
K5K99_00875	COG3842	ATPase activity
K5K99_00885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5K99_00890	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K5K99_00895	COG0084	hydrolase, TatD family'
K5K99_00900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_00900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_00910	COG1914	H( )-stimulated, divalent metal cation uptake system
K5K99_00920	COG2207	Transcriptional regulator
K5K99_00920	COG3708	Transcriptional regulator
K5K99_00925	COG0456	acetyltransferase
K5K99_00930	COG1418	mRNA catabolic process
K5K99_00935	COG0366	Alpha amylase catalytic
K5K99_00940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_00940	COG1263	PTS System
K5K99_00945	COG2188	Transcriptional regulator
K5K99_00950	COG0415	Belongs to the DNA photolyase family
K5K99_00955	COG1737	Transcriptional regulator
K5K99_00975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K5K99_00990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_01000	COG1053	succinate dehydrogenase
K5K99_01000	COG3976	FMN-binding domain protein
K5K99_01005	COG4607	ABC-type enterochelin transport system periplasmic component
K5K99_01010	COG4604	ABC transporter, ATP-binding protein
K5K99_01015	COG4605	iron ion homeostasis
K5K99_01020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5K99_01025	COG5506	Protein of unknown function (DUF1694)
K5K99_01030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5K99_01045	COG2188	Transcriptional regulator
K5K99_01050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_01055	COG2723	6-phospho-beta-galactosidase activity
K5K99_01060	COG2918	glutathione biosynthetic process
K5K99_01060	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K99_01065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_01065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_01065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_01070	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K99_01075	COG1349	DNA-binding transcription factor activity
K5K99_01080	COG0552	protein localization to endoplasmic reticulum
K5K99_01085	COG0561	phosphatase activity
K5K99_01090	COG1196	nuclear chromosome segregation
K5K99_01095	COG0571	ribonuclease III activity
K5K99_01100	COG0747	negative chemotaxis
K5K99_01105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K99_01110	COG0601	transmembrane transport
K5K99_01115	COG4608	Belongs to the ABC transporter superfamily
K5K99_01125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K99_01130	COG0416	fatty acid biosynthetic process
K5K99_01135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5K99_01140	COG1461	Dihydroxyacetone kinase
K5K99_01150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5K99_01155	COG1564	THIamine pyrophosphokinase
K5K99_01160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5K99_01165	COG1162	GTPase activity
K5K99_01170	COG0515	serine threonine protein kinase
K5K99_01170	COG2815	serine threonine protein kinase
K5K99_01180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K99_01180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5K99_01185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5K99_01190	COG0242	peptide deformylase activity
K5K99_01195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5K99_01210	COG0384	phenazine biosynthesis protein PhzF
K5K99_01220	COG0194	GDP metabolic process
K5K99_01225	COG1561	YicC-like family, N-terminal region
K5K99_01245	COG0736	holo-[acyl-carrier-protein] synthase activity
K5K99_01255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K99_01260	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K99_01270	COG3764	Sortase (surface protein transpeptidase)
K5K99_01275	COG3481	metal-dependent phosphohydrolase, HD sub domain
K5K99_01280	COG4717	serine-type aminopeptidase activity
K5K99_01290	COG3679	Belongs to the UPF0342 family
K5K99_01295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K99_01300	COG0564	pseudouridine synthase activity
K5K99_01320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K99_01335	COG1438	arginine binding
K5K99_01340	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K99_01350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K99_01370	COG2814	Major facilitator Superfamily
K5K99_01380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K99_01405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K99_01425	COG3279	Response regulator of the LytR AlgR family
K5K99_01435	COG4166	transmembrane transport
K5K99_01445	COG1247	-acetyltransferase
K5K99_01455	COG0110	maltose O-acetyltransferase activity
K5K99_01465	COG0427	acetyl-CoA hydrolase
K5K99_01470	COG1024	Enoyl-CoA hydratase
K5K99_01475	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K99_01480	COG0183	Belongs to the thiolase family
K5K99_01485	COG0583	DNA-binding transcription factor activity
K5K99_01490	COG1960	acyl-CoA dehydrogenase activity
K5K99_01505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K99_01510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K99_01520	COG2323	membrane
K5K99_01530	COG2723	6-phospho-beta-galactosidase activity
K5K99_01535	COG1737	Transcriptional regulator
K5K99_01545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_01550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K99_01615	COG0400	carboxylic ester hydrolase activity
K5K99_01620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5K99_01625	COG0346	lactoylglutathione lyase activity
K5K99_01630	COG0346	lactoylglutathione lyase activity
K5K99_01635	COG1846	Transcriptional regulator
K5K99_01655	COG2070	2-Nitropropane dioxygenase
K5K99_01665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5K99_01670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K5K99_01675	COG1024	Enoyl-CoA hydratase
K5K99_01680	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K99_01685	COG0183	Belongs to the thiolase family
K5K99_01690	COG0583	DNA-binding transcription factor activity
K5K99_01700	COG0346	lactoylglutathione lyase activity
K5K99_01710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K99_01725	COG1304	FMN binding
K5K99_01730	COG1346	cytolysis
K5K99_01735	COG1380	Effector of murein hydrolase LrgA
K5K99_01750	COG1054	Belongs to the UPF0176 family
K5K99_01760	COG0604	alcohol dehydrogenase
K5K99_01770	COG0656	L-ascorbic acid biosynthetic process
K5K99_01775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_01820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5K99_01845	COG0475	glutathione-regulated potassium exporter activity
K5K99_01875	COG3759	membrane
K5K99_01880	COG0778	Nitroreductase
K5K99_01885	COG1846	Transcriptional regulator
K5K99_01900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5K99_01925	COG1309	transcriptional regulator
K5K99_01930	COG2723	6-phospho-beta-galactosidase activity
K5K99_01935	COG2190	(PTS) system
K5K99_01935	COG1263	PTS System
K5K99_01935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_01940	COG3711	transcriptional antiterminator
K5K99_02025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5K99_02030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5K99_02045	COG1122	ATPase activity
K5K99_02050	COG1122	ATPase activity
K5K99_02055	COG0203	ribosomal protein L17
K5K99_02060	COG0202	RNA polymerase activity
K5K99_02065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5K99_02070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5K99_02075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5K99_02080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5K99_02085	COG0563	adenylate kinase activity
K5K99_02095	COG0200	Binds to the 23S rRNA
K5K99_02100	COG1841	ribosomal large subunit assembly
K5K99_02105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5K99_02115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5K99_02120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5K99_02125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K99_02130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5K99_02135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5K99_02140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5K99_02145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5K99_02150	COG0255	Belongs to the universal ribosomal protein uL29 family
K5K99_02155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5K99_02160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5K99_02165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5K99_02170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5K99_02175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5K99_02180	COG0089	rRNA binding
K5K99_02185	COG0088	Forms part of the polypeptide exit tunnel
K5K99_02190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5K99_02195	COG0051	transcription antitermination factor activity, RNA binding
K5K99_02205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5K99_02210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5K99_02215	COG0049	tRNA binding
K5K99_02220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5K99_02225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5K99_02230	COG0588	phosphoglycerate mutase activity
K5K99_02250	COG1114	Component of the transport system for branched-chain amino acids
K5K99_02415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5K99_02425	COG0516	GMP reductase activity
K5K99_02425	COG0517	IMP dehydrogenase activity
K5K99_02435	COG0012	GTP binding
K5K99_02440	COG4481	Protein conserved in bacteria
K5K99_02445	COG1475	DNA binding
K5K99_02450	COG1192	Involved in chromosome partitioning
K5K99_02455	COG0357	Ribosomal RNA small subunit methyltransferase G
K5K99_02470	COG0445	tRNA wobble uridine modification
K5K99_02475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5K99_02480	COG2153	protein acetylation
K5K99_02485	COG0018	arginyl-trna synthetase
K5K99_02495	COG0706	membrane insertase activity
K5K99_02500	COG0594	ribonuclease P activity
K5K99_02505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5K99_02510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5K99_02515	COG0592	DNA-directed DNA polymerase activity
K5K99_02525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5K99_02530	COG0187	DNA topoisomerase II activity
K5K99_02540	COG0360	Binds together with S18 to 16S ribosomal RNA
K5K99_02545	COG0629	single-stranded DNA binding
K5K99_02550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5K99_02555	COG0359	binds to the 23S rRNA
K5K99_02560	COG0305	Participates in initiation and elongation during chromosome replication
K5K99_02565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5K99_02585	COG0488	(ABC) transporter
K5K99_02600	COG0142	geranyltranstransferase activity
K5K99_02615	COG4939	FMN-binding domain protein
K5K99_02635	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5K99_02650	COG1609	Transcriptional regulator
K5K99_02655	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5K99_02665	COG1744	ABC transporter substrate-binding protein PnrA-like
K5K99_02670	COG3845	ABC transporter
K5K99_02675	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5K99_02680	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5K99_02685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5K99_02695	COG0813	purine-nucleoside phosphorylase activity
K5K99_02715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5K99_02720	COG0477	Major facilitator Superfamily
K5K99_02735	COG1686	Belongs to the peptidase S11 family
K5K99_02740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K5K99_02745	COG1242	4 iron, 4 sulfur cluster binding
K5K99_02750	COG0671	phosphoesterase, PA-phosphatase related
K5K99_02765	COG1388	LysM domain
K5K99_02765	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_02770	COG0495	leucyl-tRNA aminoacylation
K5K99_02775	COG2244	polysaccharide biosynthetic process
K5K99_02780	COG1187	pseudouridine synthase activity
K5K99_02785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_02805	COG1126	abc transporter atp-binding protein
K5K99_02810	COG0765	amino acid transport
K5K99_02820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5K99_02830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5K99_02850	COG0395	ABC-type sugar transport system, permease component
K5K99_02860	COG1554	hydrolase, family 65, central catalytic
K5K99_02865	COG1609	Transcriptional regulator
K5K99_02875	COG0366	Alpha amylase catalytic
K5K99_02880	COG1653	transport
K5K99_02885	COG1175	transmembrane transport
K5K99_02890	COG0395	ABC-type sugar transport system, permease component
K5K99_02895	COG3842	ATPase activity
K5K99_02915	COG5294	Protein conserved in bacteria
K5K99_02955	COG1396	sequence-specific DNA binding
K5K99_02960	COG3620	sequence-specific DNA binding
K5K99_02965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K99_03000	COG3328	transposase activity
K5K99_03015	COG3328	transposase activity
K5K99_03020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K5K99_03040	COG0659	secondary active sulfate transmembrane transporter activity
K5K99_03045	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_03055	COG1269	ATP hydrolysis coupled proton transport
K5K99_03060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K99_03070	COG1527	subunit (C
K5K99_03075	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
K5K99_03080	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5K99_03085	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K5K99_03090	COG1394	ATPase activity, coupled to movement of substances
K5K99_03100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5K99_03105	COG3328	transposase activity
K5K99_03120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K99_03130	COG0039	L-malate dehydrogenase activity
K5K99_03135	COG0193	aminoacyl-tRNA hydrolase activity
K5K99_03140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5K99_03145	COG2244	polysaccharide biosynthetic process
K5K99_03150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5K99_03160	COG1098	S1 RNA binding domain
K5K99_03165	COG0037	tRNA processing
K5K99_03170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5K99_03175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5K99_03180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5K99_03185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K99_03190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5K99_03265	COG3620	sequence-specific DNA binding
K5K99_03370	COG4463	regulation of RNA biosynthetic process
K5K99_03375	COG0542	response to heat
K5K99_03385	COG0826	peptidase U32
K5K99_03390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K99_03395	COG1271	oxidase subunit
K5K99_03400	COG1294	oxidase, subunit
K5K99_03405	COG4988	ABC transporter
K5K99_03410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5K99_03425	COG1054	Belongs to the UPF0176 family
K5K99_03475	COG0363	glucosamine-6-phosphate deaminase activity
K5K99_03480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K99_03510	COG0798	PFAM Bile acid sodium symporter
K5K99_03570	COG1442	glycosyl transferase family 8
K5K99_03590	COG0640	Transcriptional regulator
K5K99_03595	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K99_03625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K99_03635	COG1609	Transcriptional regulator
K5K99_03650	COG0488	(ABC) transporter
K5K99_03655	COG0488	(ABC) transporter
K5K99_03660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5K99_03675	COG0628	permease
K5K99_03690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5K99_03695	COG1426	Protein conserved in bacteria
K5K99_03700	COG0300	oxidoreductase activity
K5K99_03705	COG0612	Peptidase, M16
K5K99_03710	COG0612	Peptidase, M16
K5K99_03715	COG1970	mechanosensitive ion channel activity
K5K99_03720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5K99_03730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_03735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K99_03740	COG1121	(ABC) transporter
K5K99_03745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5K99_03755	COG1177	transmembrane transport
K5K99_03760	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5K99_03765	COG3842	ATPase activity
K5K99_03775	COG0604	alcohol dehydrogenase
K5K99_03835	COG1473	amidohydrolase
K5K99_03840	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5K99_03845	COG0038	chloride channel
K5K99_03855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K99_03860	COG4565	transcriptional regulatory protein
K5K99_03865	COG3290	protein histidine kinase activity
K5K99_03870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5K99_03875	COG0708	Exodeoxyribonuclease III
K5K99_03895	COG0802	atpase or kinase
K5K99_03905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K99_03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_03915	COG1263	PTS System
K5K99_03915	COG2190	(PTS) system
K5K99_03925	COG1609	Transcriptional regulator
K5K99_03935	COG0280	phosphate acetyltransferase
K5K99_03945	COG0561	phosphatase activity
K5K99_03955	COG0025	NhaP-type Na H and K H
K5K99_03960	COG1278	Cold shock
K5K99_03980	COG0745	RESPONSE REGULATOR receiver
K5K99_03985	COG5002	protein histidine kinase activity
K5K99_03990	COG2433	Pfam Transposase IS66
K5K99_04015	COG1131	(ABC) transporter
K5K99_04060	COG1215	transferase activity, transferring glycosyl groups
K5K99_04070	COG2188	Transcriptional regulator
K5K99_04095	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5K99_04125	COG1285	pathogenesis
K5K99_04130	COG0251	oxidation-reduction process
K5K99_04150	COG2390	Transcriptional regulator
K5K99_04155	COG0583	DNA-binding transcription factor activity
K5K99_04160	COG4166	transmembrane transport
K5K99_04165	COG0402	S-adenosylhomocysteine deaminase activity
K5K99_04170	COG0402	S-adenosylhomocysteine deaminase activity
K5K99_04175	COG4335	DNA alkylation repair
K5K99_04200	COG3448	diguanylate cyclase activity
K5K99_04200	COG4175	Glycine betaine
K5K99_04225	COG1175	transmembrane transport
K5K99_04230	COG0395	ABC-type sugar transport system, permease component
K5K99_04235	COG3250	beta-galactosidase activity
K5K99_04250	COG1609	Transcriptional regulator
K5K99_04260	COG1132	(ABC) transporter
K5K99_04265	COG1132	(ABC) transporter
K5K99_04270	COG0765	amino acid transport
K5K99_04275	COG1126	abc transporter atp-binding protein
K5K99_04280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5K99_04290	COG0435	Glutathione S-transferase
K5K99_04300	COG3022	response to hydroperoxide
K5K99_04305	COG2252	PERMEase
K5K99_04325	COG5504	Zn-dependent protease
K5K99_04330	COG2723	6-phospho-beta-galactosidase activity
K5K99_04335	COG1940	carbohydrate kinase activity
K5K99_04345	COG3973	AAA domain
K5K99_04365	COG0531	amino acid
K5K99_04375	COG1757	Na H antiporter
K5K99_04395	COG4166	transmembrane transport
K5K99_04410	COG1136	(ABC) transporter
K5K99_04415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5K99_04415	COG0519	Catalyzes the synthesis of GMP from XMP
K5K99_04420	COG1072	(Pantothenic acid kinase))
K5K99_04425	COG2755	lipolytic protein G-D-S-L family
K5K99_04430	COG2813	Specifically methylates the guanine in position
K5K99_04435	COG0085	RNA polymerase activity
K5K99_04440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5K99_04455	COG3711	transcriptional antiterminator
K5K99_04460	COG1263	PTS System
K5K99_04460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_04460	COG2190	(PTS) system
K5K99_04465	COG2723	6-phospho-beta-galactosidase activity
K5K99_04480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5K99_04485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5K99_04495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5K99_04505	COG3158	transport of potassium into the cell
K5K99_04510	COG0756	dUTP diphosphatase activity
K5K99_04520	COG4956	integral membrane protein (PIN domain superfamily)
K5K99_04525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5K99_04530	COG1045	serine acetyltransferase
K5K99_04535	COG0215	cysteine-tRNA ligase activity
K5K99_04540	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K5K99_04545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K99_04550	COG3688	RNA-binding protein containing a PIN domain
K5K99_04560	COG4466	Protein conserved in bacteria
K5K99_04565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5K99_04570	COG4980	gas vesicle protein
K5K99_04575	COG0537	adenosine 5'-monophosphoramidase activity
K5K99_04580	COG1131	(ABC) transporter
K5K99_04585	COG4473	ABC transporter
K5K99_04590	COG0510	thiamine kinase activity
K5K99_04595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5K99_04600	COG1611	Belongs to the LOG family
K5K99_04605	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K99_04620	COG1363	Peptidase, m42
K5K99_04625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K99_04635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_04640	COG4472	Bacterial protein of unknown function (DUF965)
K5K99_04645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5K99_04660	COG3906	Belongs to the UPF0473 family
K5K99_04665	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K99_04680	COG1193	negative regulation of DNA recombination
K5K99_04685	COG3118	belongs to the thioredoxin family
K5K99_04690	COG0322	excinuclease ABC activity
K5K99_04715	COG4152	abc transporter atp-binding protein
K5K99_04720	COG1668	transmembrane transport
K5K99_04730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5K99_04735	COG2116	formate transmembrane transporter activity
K5K99_04740	COG0561	phosphatase activity
K5K99_04745	COG0242	peptide deformylase activity
K5K99_04750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5K99_04755	COG1185	polyribonucleotide nucleotidyltransferase activity
K5K99_04770	COG0383	alpha-mannosidase activity
K5K99_04780	COG1609	Transcriptional regulator
K5K99_04790	COG1940	carbohydrate kinase activity
K5K99_04800	COG1649	PFAM Uncharacterised BCR, COG1649
K5K99_04815	COG1309	transcriptional regulator
K5K99_04820	COG2376	Dihydroxyacetone kinase
K5K99_04825	COG1461	Dihydroxyacetone kinase
K5K99_04830	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K5K99_04835	COG0371	Dehydrogenase
K5K99_04840	COG2376	Dihydroxyacetone kinase
K5K99_04880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5K99_04885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5K99_04890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5K99_04895	COG0028	Belongs to the TPP enzyme family
K5K99_04905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K99_04910	COG2011	ABC-type metal ion transport system permease component
K5K99_04945	COG0642	Histidine kinase
K5K99_04955	COG1136	(ABC) transporter
K5K99_04960	COG0577	efflux transmembrane transporter activity
K5K99_04965	COG1363	Peptidase, m42
K5K99_04980	COG0577	efflux transmembrane transporter activity
K5K99_04985	COG1234	tRNA 3'-trailer cleavage
K5K99_04990	COG0095	Lipoate-protein ligase
K5K99_04995	COG0740	serine-type endopeptidase activity
K5K99_05000	COG0180	Tryptophanyl-tRNA synthetase
K5K99_05005	COG1393	Belongs to the ArsC family
K5K99_05010	COG4862	establishment of competence for transformation
K5K99_05020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K99_05025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K99_05030	COG1780	Probably involved in ribonucleotide reductase function
K5K99_05035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5K99_05055	COG0582	viral genome integration into host DNA
K5K99_05080	COG1396	sequence-specific DNA binding
K5K99_05320	COG3953	SLT domain
K5K99_05320	COG5412	phage tail tape measure protein
K5K99_05370	COG0745	RESPONSE REGULATOR receiver
K5K99_05375	COG5002	protein histidine kinase activity
K5K99_05390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5K99_05395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5K99_05400	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5K99_05405	COG0582	viral genome integration into host DNA
K5K99_05415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K99_05420	COG1396	sequence-specific DNA binding
K5K99_05715	COG2003	Belongs to the UPF0758 family
K5K99_05770	COG1573	uracil-dna glycosylase
K5K99_05795	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K5K99_05800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K99_05805	COG2169	Transcriptional regulator
K5K99_05810	COG4166	transmembrane transport
K5K99_05825	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5K99_05830	COG1175	transmembrane transport
K5K99_05835	COG0395	ABC-type sugar transport system, permease component
K5K99_05855	COG1737	Transcriptional regulator
K5K99_05860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K99_05865	COG4166	transmembrane transport
K5K99_05875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5K99_05880	COG0626	cystathionine gamma-synthase activity
K5K99_05905	COG0673	inositol 2-dehydrogenase activity
K5K99_05915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_05920	COG1609	Transcriptional regulator
K5K99_05930	COG1175	transmembrane transport
K5K99_05935	COG0395	ABC-type sugar transport system, permease component
K5K99_05940	COG1621	beta-fructofuranosidase activity
K5K99_05945	COG1940	carbohydrate kinase activity
K5K99_05955	COG1737	Transcriptional regulator
K5K99_05960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_05965	COG2723	6-phospho-beta-galactosidase activity
K5K99_05970	COG1940	carbohydrate kinase activity
K5K99_05975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_05980	COG2188	Transcriptional regulator
K5K99_05985	COG2723	6-phospho-beta-galactosidase activity
K5K99_06000	COG0789	Transcriptional regulator
K5K99_06005	COG0667	Aldo Keto reductase
K5K99_06010	COG1846	Transcriptional regulator
K5K99_06015	COG2814	Major facilitator Superfamily
K5K99_06020	COG1132	(ABC) transporter
K5K99_06035	COG0745	RESPONSE REGULATOR receiver
K5K99_06040	COG1414	Transcriptional regulator
K5K99_06045	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K5K99_06050	COG1028	Short-chain dehydrogenase reductase Sdr
K5K99_06060	COG0800	Aldolase
K5K99_06075	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K99_06075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K99_06080	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K5K99_06085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_06090	COG3715	PTS system
K5K99_06120	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K99_06125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_06125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_06125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_06130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_06130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_06130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_06135	COG3684	Belongs to the aldolase LacD family
K5K99_06145	COG3716	PTS system mannose fructose sorbose family IID component
K5K99_06150	COG2188	Transcriptional regulator
K5K99_06155	COG2222	sugar isomerase
K5K99_06160	COG3684	Belongs to the aldolase LacD family
K5K99_06165	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K99_06170	COG1187	pseudouridine synthase activity
K5K99_06175	COG0217	transcriptional regulatory protein
K5K99_06185	COG1132	(ABC) transporter
K5K99_06190	COG1132	(ABC) transporter
K5K99_06200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5K99_06220	COG0641	radical SAM
K5K99_06230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5K99_06250	COG0395	ABC-type sugar transport system, permease component
K5K99_06255	COG1175	transmembrane transport
K5K99_06265	COG0564	pseudouridine synthase activity
K5K99_06270	COG4684	Psort location CytoplasmicMembrane, score
K5K99_06290	COG3730	PTS system glucitol sorbitol-specific
K5K99_06295	COG3732	PTS system glucitol sorbitol-specific
K5K99_06310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K99_06320	COG0604	alcohol dehydrogenase
K5K99_06340	COG2169	Transcriptional regulator
K5K99_06350	COG0698	ribose 5-phosphate isomerase
K5K99_06365	COG3775	system Galactitol-specific IIC component
K5K99_06370	COG0235	Class ii aldolase
K5K99_06375	COG3414	Phosphotransferase system galactitol-specific IIB component
K5K99_06380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K99_06385	COG0022	dehydrogenase e1 component
K5K99_06415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5K99_06425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K5K99_06430	COG0352	thiamine-phosphate diphosphorylase activity
K5K99_06435	COG0351	phosphomethylpyrimidine kinase
K5K99_06440	COG0531	amino acid
K5K99_06445	COG0662	Cupin 2, conserved barrel domain protein
K5K99_06475	COG3639	organic phosphonate transmembrane transporter activity
K5K99_06480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K5K99_06490	COG1695	Transcriptional regulator
K5K99_06495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_06510	COG0159	tryptophan synthase activity
K5K99_06535	COG0513	Belongs to the DEAD box helicase family
K5K99_06540	COG0105	UTP biosynthetic process
K5K99_06550	COG5002	protein histidine kinase activity
K5K99_06570	COG0431	NADPH-dependent FMN reductase
K5K99_06570	COG3976	FMN-binding domain protein
K5K99_06570	COG1053	succinate dehydrogenase
K5K99_06580	COG0714	Associated with various cellular activities
K5K99_06590	COG1305	Transglutaminase-like
K5K99_06600	COG1609	Transcriptional regulator
K5K99_06610	COG1869	D-ribose catabolic process
K5K99_06615	COG4975	Glucose uptake
K5K99_06650	COG2190	(PTS) system
K5K99_06650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_06650	COG1263	PTS System
K5K99_06655	COG3711	transcriptional antiterminator
K5K99_06660	COG2213	PTS system mannitol-specific
K5K99_06665	COG3711	transcriptional antiterminator
K5K99_06670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_06675	COG2213	PTS system mannitol-specific
K5K99_06680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_06685	COG0246	Mannitol dehydrogenase
K5K99_06750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K5K99_06755	COG1609	Transcriptional regulator
K5K99_06760	COG2017	converts alpha-aldose to the beta-anomer
K5K99_06765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5K99_06770	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5K99_06775	COG1609	Transcriptional regulator
K5K99_06795	COG0745	RESPONSE REGULATOR receiver
K5K99_06805	COG0367	asparagine synthase
K5K99_06825	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K5K99_06835	COG0823	Involved in the tonB-independent uptake of proteins
K5K99_06835	COG4946	Tricorn protease homolog
K5K99_06835	COG1506	peptidase
K5K99_06845	COG1126	abc transporter atp-binding protein
K5K99_06850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K99_06855	COG0765	amino acid transport
K5K99_06860	COG0765	amino acid transport
K5K99_06870	COG1268	BioY protein
K5K99_06880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K99_06885	COG2011	ABC-type metal ion transport system permease component
K5K99_06890	COG1464	Belongs to the NlpA lipoprotein family
K5K99_06900	COG1486	melibiose metabolic process
K5K99_06905	COG1609	Transcriptional regulator
K5K99_06920	COG3404	Formiminotransferase-cyclodeaminase
K5K99_06925	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K5K99_06935	COG0531	amino acid
K5K99_06945	COG0124	histidyl-tRNA synthetase
K5K99_06950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_06955	COG0456	acetyltransferase
K5K99_06960	COG1597	lipid kinase activity
K5K99_06965	COG1228	amidohydrolase
K5K99_06970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5K99_06995	COG1070	Carbohydrate kinase
K5K99_07000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5K99_07005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K99_07010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5K99_07025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5K99_07030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K99_07040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K99_07050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5K99_07055	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5K99_07060	COG0138	bifunctional purine biosynthesis protein purh
K5K99_07075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K99_07080	COG1534	Rna-binding protein
K5K99_07085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5K99_07095	COG0799	negative regulation of ribosome biogenesis
K5K99_07100	COG2226	methyltransferase
K5K99_07105	COG1323	Belongs to the UPF0348 family
K5K99_07125	COG3655	Transcriptional regulator
K5K99_07130	COG1304	FMN binding
K5K99_07145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5K99_07150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5K99_07155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K99_07170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5K99_07175	COG1121	(ABC) transporter
K5K99_07180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K99_07195	COG0300	oxidoreductase activity
K5K99_07205	COG0772	Belongs to the SEDS family
K5K99_07215	COG1393	Belongs to the ArsC family
K5K99_07220	COG0509	glycine decarboxylation via glycine cleavage system
K5K99_07225	COG0716	FMN binding
K5K99_07235	COG3706	GGDEF domain
K5K99_07245	COG2738	Putative neutral zinc metallopeptidase
K5K99_07250	COG2508	Transcriptional regulator
K5K99_07255	COG0590	tRNA wobble adenosine to inosine editing
K5K99_07265	COG1428	Deoxynucleoside kinase
K5K99_07290	COG1653	transport
K5K99_07295	COG1175	transmembrane transport
K5K99_07300	COG0395	ABC-type sugar transport system, permease component
K5K99_07305	COG0366	Alpha amylase catalytic
K5K99_07310	COG1960	acyl-CoA dehydrogenase activity
K5K99_07315	COG0583	DNA-binding transcription factor activity
K5K99_07320	COG0183	Belongs to the thiolase family
K5K99_07325	COG1960	acyl-CoA dehydrogenase activity
K5K99_07330	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K99_07335	COG1024	Enoyl-CoA hydratase
K5K99_07340	COG0427	acetyl-CoA hydrolase
K5K99_07345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5K99_07350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K99_07355	COG0351	phosphomethylpyrimidine kinase
K5K99_07360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_07395	COG0504	CTP synthase activity
K5K99_07420	COG1335	isochorismatase
K5K99_07425	COG1522	sequence-specific DNA binding
K5K99_07435	COG0681	Belongs to the peptidase S26 family
K5K99_07445	COG1136	(ABC) transporter
K5K99_07445	COG0577	efflux transmembrane transporter activity
K5K99_07450	COG0577	efflux transmembrane transporter activity
K5K99_07450	COG1136	(ABC) transporter
K5K99_07465	COG3425	synthase
K5K99_07470	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5K99_07475	COG1363	Peptidase, m42
K5K99_07490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K99_07505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_07520	COG2807	transmembrane transport
K5K99_07525	COG1396	sequence-specific DNA binding
K5K99_07545	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K5K99_07550	COG1074	ATP-dependent DNA helicase activity
K5K99_07565	COG3853	Toxic anion resistance protein (TelA)
K5K99_07570	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K5K99_07585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K99_07590	COG1335	isochorismatase
K5K99_07595	COG2855	membrane
K5K99_07610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K99_07615	COG2706	6-phosphogluconolactonase activity
K5K99_07625	COG0628	permease
K5K99_07630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5K99_07635	COG1435	thymidine kinase activity
K5K99_07640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5K99_07645	COG2890	protein-(glutamine-N5) methyltransferase activity
K5K99_07650	COG0009	L-threonylcarbamoyladenylate synthase
K5K99_07655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5K99_07660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5K99_07675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5K99_07680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K99_07700	COG0116	Belongs to the methyltransferase superfamily
K5K99_07705	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5K99_07710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K99_07715	COG3588	fructose-bisphosphate aldolase
K5K99_07720	COG2188	Transcriptional regulator
K5K99_07725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_07740	COG3964	amidohydrolase
K5K99_07760	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K99_07775	COG1131	(ABC) transporter
K5K99_07785	COG2365	Tyrosine phosphatase family
K5K99_07790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K99_07795	COG0737	Belongs to the 5'-nucleotidase family
K5K99_07800	COG4470	Protein conserved in bacteria
K5K99_07805	COG0647	UMP catabolic process
K5K99_07820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5K99_07825	COG0492	ferredoxin-NADP+ reductase activity
K5K99_07840	COG1132	(ABC) transporter
K5K99_07855	COG1482	cell wall glycoprotein biosynthetic process
K5K99_07860	COG1609	Transcriptional regulator
K5K99_07865	COG0686	Belongs to the AlaDH PNT family
K5K99_07870	COG3442	glutamine amidotransferase
K5K99_07875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K99_07885	COG0601	transmembrane transport
K5K99_07890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K99_07895	COG0444	Belongs to the ABC transporter superfamily
K5K99_07900	COG4608	Belongs to the ABC transporter superfamily
K5K99_07910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K99_07925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5K99_07930	COG0328	RNA-DNA hybrid ribonuclease activity
K5K99_07940	COG1278	Cold shock
K5K99_07945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5K99_07950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5K99_07955	COG0735	belongs to the Fur family
K5K99_08080	COG1696	Membrane protein involved in D-alanine export
K5K99_08085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K99_08090	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K5K99_08105	COG2391	methyltransferase activity
K5K99_08110	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_08115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K99_08120	COG4521	taurine ABC transporter
K5K99_08125	COG1116	anion transmembrane transporter activity
K5K99_08130	COG0741	lytic transglycosylase activity
K5K99_08135	COG0726	polysaccharide deacetylase
K5K99_08140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K5K99_08140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5K99_08145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_08150	COG1175	transmembrane transport
K5K99_08155	COG0395	ABC-type sugar transport system, permease component
K5K99_08160	COG1653	transport
K5K99_08170	COG2972	Histidine kinase
K5K99_08175	COG4753	response regulator
K5K99_08175	COG2207	Transcriptional regulator
K5K99_08190	COG2824	Alkylphosphonate utilization operon protein PhnA
K5K99_08195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5K99_08200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5K99_08210	COG4585	Histidine kinase
K5K99_08215	COG2197	response regulator
K5K99_08220	COG0569	domain protein
K5K99_08225	COG4841	protein insertion into membrane
K5K99_08235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5K99_08240	COG4838	Belongs to the UPF0358 family
K5K99_08245	COG0772	Belongs to the SEDS family
K5K99_08250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K5K99_08265	COG4471	UPF0298 protein
K5K99_08275	COG0488	(ABC) transporter
K5K99_08285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K99_08290	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5K99_08295	COG1253	flavin adenine dinucleotide binding
K5K99_08300	COG0494	nUDIX hydrolase
K5K99_08305	COG1214	PFAM Peptidase M22, glycoprotease
K5K99_08315	COG0456	acetyltransferase
K5K99_08320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5K99_08335	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5K99_08350	COG1473	amidohydrolase
K5K99_08355	COG0668	transmembrane transport
K5K99_08370	COG1609	Transcriptional regulator
K5K99_08375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K99_08380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5K99_08385	COG3763	UPF0154 protein
K5K99_08390	COG1132	(ABC) transporter
K5K99_08395	COG1132	(ABC) transporter
K5K99_08405	COG1609	Transcriptional regulator
K5K99_08410	COG0366	Alpha amylase catalytic
K5K99_08420	COG2182	Extracellular solute-binding protein
K5K99_08425	COG1175	transmembrane transport
K5K99_08430	COG3833	ABC-type maltose transport systems, permease component
K5K99_08445	COG0534	Mate efflux family protein
K5K99_08455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K99_08460	COG0640	Transcriptional regulator
K5K99_08470	COG0083	homoserine kinase activity
K5K99_08485	COG1254	Belongs to the acylphosphatase family
K5K99_08490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K99_08500	COG1733	regulation of RNA biosynthetic process
K5K99_08505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5K99_08510	COG0072	phenylalanine-tRNA ligase activity
K5K99_08510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_08515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5K99_08520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5K99_08525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_08535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5K99_08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K99_08550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5K99_08560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5K99_08570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5K99_08575	COG0439	Biotin carboxylase
K5K99_08580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5K99_08585	COG0825	malonyl-CoA metabolic process
K5K99_08595	COG2151	metal-sulfur cluster biosynthetic enzyme
K5K99_08635	COG1523	belongs to the glycosyl hydrolase 13 family
K5K99_08640	COG2267	carboxylic ester hydrolase activity
K5K99_08660	COG3328	transposase activity
K5K99_08695	COG5566	PFAM Mor transcription activator
K5K99_08700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K99_08705	COG1073	alpha beta
K5K99_08710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K99_08770	COG0745	RESPONSE REGULATOR receiver
K5K99_08775	COG3850	Histidine kinase
K5K99_08775	COG5002	protein histidine kinase activity
K5K99_08780	COG4476	Belongs to the UPF0223 family
K5K99_08785	COG0483	inositol monophosphate 1-phosphatase activity
K5K99_08790	COG1217	gtp-binding protein TYPA
K5K99_08805	COG0210	DNA helicase
K5K99_08810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5K99_08815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K99_08820	COG0154	amidase activity
K5K99_08825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K99_08830	COG1597	lipid kinase activity
K5K99_08835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5K99_08865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K99_08880	COG2608	mercury ion transmembrane transporter activity
K5K99_08900	COG3328	transposase activity
K5K99_08910	COG3328	transposase activity
K5K99_08920	COG1136	(ABC) transporter
K5K99_08935	COG5002	protein histidine kinase activity
K5K99_08990	COG2030	dehydratase
K5K99_09005	COG1368	sulfuric ester hydrolase activity
K5K99_09010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5K99_09015	COG0710	3-dehydroquinate dehydratase activity
K5K99_09020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5K99_09025	COG2081	HI0933 family
K5K99_09030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5K99_09035	COG0166	Belongs to the GPI family
K5K99_09060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5K99_09070	COG0670	Belongs to the BI1 family
K5K99_09075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K99_09075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K99_09080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5K99_09085	COG0237	dephospho-CoA kinase activity
K5K99_09090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5K99_09100	COG1484	DNA-dependent DNA replication
K5K99_09110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K99_09115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5K99_09135	COG0765	amino acid transport
K5K99_09140	COG1126	abc transporter atp-binding protein
K5K99_09145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K99_09170	COG0737	Belongs to the 5'-nucleotidase family
K5K99_09190	COG0187	DNA topoisomerase II activity
K5K99_09195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5K99_09200	COG1882	Formate acetyltransferase
K5K99_09205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5K99_09220	COG2076	Multidrug Resistance protein
K5K99_09225	COG2076	Multidrug Resistance protein
K5K99_09230	COG1227	inorganic diphosphatase activity
K5K99_09240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K99_09250	COG0564	pseudouridine synthase activity
K5K99_09260	COG2233	PERMEase
K5K99_09265	COG0540	Belongs to the ATCase OTCase family
K5K99_09270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5K99_09275	COG0505	Belongs to the CarA family
K5K99_09280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5K99_09285	COG0543	2 iron, 2 sulfur cluster binding
K5K99_09290	COG0167	dihydroorotate dehydrogenase activity
K5K99_09295	COG0284	orotidine-5'-phosphate decarboxylase activity
K5K99_09330	COG1278	Cold shock
K5K99_09335	COG0531	amino acid
K5K99_09345	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K5K99_09365	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5K99_09370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5K99_09400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_09410	COG3328	transposase activity
K5K99_09435	COG0577	efflux transmembrane transporter activity
K5K99_09435	COG1136	(ABC) transporter
K5K99_09435	COG0577	efflux transmembrane transporter activity
K5K99_09435	COG1136	(ABC) transporter
K5K99_09440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K99_09455	COG0768	penicillin binding
K5K99_09460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5K99_09465	COG1472	Belongs to the glycosyl hydrolase 3 family
K5K99_09480	COG4895	conserved protein (DUF2196)
K5K99_09545	COG0481	GTPase activity
K5K99_09555	COG0542	response to heat
K5K99_09565	COG0463	Glycosyl transferase, family 2
K5K99_09575	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K99_09580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5K99_09585	COG2384	SAM-dependent methyltransferase
K5K99_09590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5K99_09595	COG0358	DNA primase activity
K5K99_09600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_09605	COG0515	serine threonine protein kinase
K5K99_09610	COG1136	(ABC) transporter
K5K99_09615	COG0577	efflux transmembrane transporter activity
K5K99_09620	COG0751	glycine-tRNA ligase activity
K5K99_09625	COG0752	glycyl-tRNA synthetase alpha subunit
K5K99_09630	COG1381	Involved in DNA repair and RecF pathway recombination
K5K99_09635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5K99_09640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5K99_09645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5K99_09655	COG1702	phosphate starvation-inducible protein PhoH
K5K99_09665	COG0735	belongs to the Fur family
K5K99_09670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K99_09680	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K5K99_09685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5K99_09690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5K99_09695	COG4974	Belongs to the 'phage' integrase family
K5K99_09700	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K5K99_09705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5K99_09710	COG0758	DNA mediated transformation
K5K99_09715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K99_09720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K99_09730	COG3409	Peptidoglycan-binding domain 1 protein
K5K99_09730	COG0793	Belongs to the peptidase S41A family
K5K99_09735	COG4479	Belongs to the UPF0346 family
K5K99_09750	COG2755	lipolytic protein G-D-S-L family
K5K99_09755	COG1307	EDD domain protein, DegV family
K5K99_09760	COG1272	protein, Hemolysin III
K5K99_09775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5K99_09780	COG0488	(ABC) transporter
K5K99_09795	COG0617	tRNA 3'-terminal CCA addition
K5K99_09800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5K99_09805	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K99_09810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_09820	COG3426	butyrate kinase activity
K5K99_09825	COG0280	phosphate acetyltransferase
K5K99_09855	COG0583	DNA-binding transcription factor activity
K5K99_09865	COG5582	Belongs to the UPF0302 family
K5K99_09890	COG1160	GTP binding
K5K99_09895	COG0539	negative regulation of cytoplasmic translation
K5K99_09900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5K99_09905	COG1134	teichoic acid transport
K5K99_09905	COG1388	LysM domain
K5K99_09910	COG0514	ATP-dependent DNA helicase (RecQ)
K5K99_09925	COG2755	lipolytic protein G-D-S-L family
K5K99_09925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5K99_09930	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5K99_09935	COG1187	pseudouridine synthase activity
K5K99_09940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5K99_09945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5K99_09950	COG4974	Belongs to the 'phage' integrase family
K5K99_09965	COG0735	belongs to the Fur family
K5K99_09970	COG2996	Protein conserved in bacteria
K5K99_09985	COG2814	Major facilitator Superfamily
K5K99_09995	COG0205	6-phosphofructokinase activity
K5K99_10000	COG0587	DNA-directed DNA polymerase activity
K5K99_10015	COG2814	Major facilitator Superfamily
K5K99_10025	COG2252	PERMEase
K5K99_10030	COG1725	Transcriptional regulator
K5K99_10035	COG1131	(ABC) transporter
K5K99_10100	COG3541	Predicted nucleotidyltransferase
K5K99_10185	COG4974	Belongs to the 'phage' integrase family
K5K99_10195	COG0577	efflux transmembrane transporter activity
K5K99_10200	COG1136	(ABC) transporter
K5K99_10205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5K99_10215	COG2153	protein acetylation
K5K99_10220	COG2910	NAD(P)H-binding
K5K99_10225	COG1959	2 iron, 2 sulfur cluster binding
K5K99_10230	COG0513	Belongs to the DEAD box helicase family
K5K99_10240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5K99_10250	COG1307	EDD domain protein, DegV family
K5K99_10260	COG0077	Prephenate dehydratase
K5K99_10265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5K99_10275	COG0287	Prephenate dehydrogenase
K5K99_10280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5K99_10290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5K99_10295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5K99_10305	COG0406	alpha-ribazole phosphatase activity
K5K99_10335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K99_10340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K99_10345	COG0509	glycine decarboxylation via glycine cleavage system
K5K99_10350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5K99_10355	COG0477	Major facilitator Superfamily
K5K99_10360	COG4166	transmembrane transport
K5K99_10365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5K99_10370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5K99_10385	COG5002	protein histidine kinase activity
K5K99_10390	COG0745	RESPONSE REGULATOR receiver
K5K99_10395	COG0114	fumarate hydratase activity
K5K99_10400	COG0281	malic enzyme
K5K99_10405	COG1027	Aspartate ammonia-lyase
K5K99_10415	COG2207	Transcriptional regulator
K5K99_10415	COG4753	response regulator
K5K99_10435	COG0772	Belongs to the SEDS family
K5K99_10445	COG1609	Transcriptional regulator
K5K99_10455	COG0745	RESPONSE REGULATOR receiver
K5K99_10465	COG1136	(ABC) transporter
K5K99_10470	COG0577	efflux transmembrane transporter activity
K5K99_10475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K99_10480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_10480	COG2190	(PTS) system
K5K99_10480	COG1263	PTS System
K5K99_10485	COG3711	transcriptional antiterminator
K5K99_10495	COG0436	Aminotransferase
K5K99_10500	COG1522	sequence-specific DNA binding
K5K99_10505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K99_10525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K5K99_10535	COG3711	transcriptional antiterminator
K5K99_10540	COG2723	6-phospho-beta-galactosidase activity
K5K99_10545	COG2190	(PTS) system
K5K99_10545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_10545	COG1263	PTS System
K5K99_10550	COG1764	response to oxidative stress
K5K99_10555	COG0335	large ribosomal subunit rRNA binding
K5K99_10560	COG0336	Belongs to the RNA methyltransferase TrmD family
K5K99_10565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5K99_10575	COG1837	Belongs to the UPF0109 family
K5K99_10585	COG1131	(ABC) transporter
K5K99_10600	COG0745	RESPONSE REGULATOR receiver
K5K99_10610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K5K99_10615	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K5K99_10620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K5K99_10645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5K99_10650	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K5K99_10655	COG5002	protein histidine kinase activity
K5K99_10660	COG0745	RESPONSE REGULATOR receiver
K5K99_10665	COG1132	(ABC) transporter
K5K99_10670	COG1132	(ABC) transporter
K5K99_10675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5K99_10685	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K99_10690	COG0484	heat shock protein binding
K5K99_10695	COG0443	Heat shock 70 kDa protein
K5K99_10700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5K99_10705	COG1420	regulation of RNA biosynthetic process
K5K99_10710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5K99_10715	COG0196	riboflavin kinase activity
K5K99_10720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5K99_10725	COG1363	Peptidase, m42
K5K99_10730	COG0673	inositol 2-dehydrogenase activity
K5K99_10735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5K99_10750	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K5K99_10755	COG0195	Participates in both transcription termination and antitermination
K5K99_10760	COG0779	Required for maturation of 30S ribosomal subunits
K5K99_10765	COG1408	metallophosphoesterase
K5K99_10775	COG0442	prolyl-tRNA aminoacylation
K5K99_10780	COG0750	zinc metalloprotease
K5K99_10785	COG4589	Belongs to the CDS family
K5K99_10790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5K99_10795	COG0233	cytoplasmic translational termination
K5K99_10800	COG0528	UMP kinase activity
K5K99_10805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5K99_10810	COG0052	Belongs to the universal ribosomal protein uS2 family
K5K99_10815	COG0588	phosphoglycerate mutase activity
K5K99_10830	COG0789	Transcriptional regulator
K5K99_10840	COG1968	undecaprenyl-diphosphatase activity
K5K99_10845	COG2217	Heavy metal translocating P-type atpase
K5K99_10850	COG1307	EDD domain protein, DegV family
K5K99_10860	COG1307	EDD domain protein, DegV family
K5K99_10870	COG1466	dna polymerase III delta subunit
K5K99_10875	COG2333	competence protein COMEC
K5K99_10875	COG0658	competence protein
K5K99_10880	COG2131	deaminase
K5K99_10885	COG1555	photosystem II stabilization
K5K99_10890	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5K99_10895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5K99_10900	COG0742	ribosomal rna small subunit methyltransferase
K5K99_10905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K99_10920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K99_10930	COG0789	Transcriptional regulator
K5K99_10935	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K5K99_10940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5K99_10945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5K99_10950	COG0584	glycerophosphoryl diester phosphodiesterase
K5K99_10960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5K99_10965	COG1940	carbohydrate kinase activity
K5K99_10975	COG0457	Tetratricopeptide repeat
K5K99_10975	COG0705	Rhomboid family
K5K99_10980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5K99_11005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K99_11010	COG0768	penicillin binding
K5K99_11015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K99_11025	COG1131	(ABC) transporter
K5K99_11030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5K99_11040	COG0577	efflux transmembrane transporter activity
K5K99_11045	COG1136	(ABC) transporter
K5K99_11050	COG0025	NhaP-type Na H and K H
K5K99_11055	COG1280	lysine exporter protein (LysE YggA)
K5K99_11055	COG1674	ftsk spoiiie
K5K99_11060	COG1012	belongs to the aldehyde dehydrogenase family
K5K99_11065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5K99_11065	COG0551	DNA topoisomerase type I activity
K5K99_11075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_11085	COG0482	sulfurtransferase activity
K5K99_11090	COG2814	Major facilitator Superfamily
K5K99_11105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5K99_11125	COG2184	nucleotidyltransferase activity
K5K99_11140	COG1104	cysteine desulfurase activity
K5K99_11145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K99_11150	COG0656	L-ascorbic acid biosynthetic process
K5K99_11170	COG1129	ABC transporter
K5K99_11185	COG0737	Belongs to the 5'-nucleotidase family
K5K99_11195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5K99_11215	COG0583	DNA-binding transcription factor activity
K5K99_11225	COG1979	alcohol dehydrogenase
K5K99_11235	COG0514	ATP-dependent DNA helicase (RecQ)
K5K99_11240	COG2860	membrane
K5K99_11255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K99_11265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K99_11270	COG0583	DNA-binding transcription factor activity
K5K99_11280	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K99_11285	COG0022	dehydrogenase e1 component
K5K99_11290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K99_11295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K99_11300	COG3426	butyrate kinase activity
K5K99_11305	COG0280	phosphate acetyltransferase
K5K99_11310	COG0386	Belongs to the glutathione peroxidase family
K5K99_11315	COG4807	Protein conserved in bacteria
K5K99_11320	COG1671	Belongs to the UPF0178 family
K5K99_11325	COG2223	nitrite transmembrane transporter activity
K5K99_11345	COG1473	amidohydrolase
K5K99_11355	COG0673	inositol 2-dehydrogenase activity
K5K99_11360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_11360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_11385	COG0673	inositol 2-dehydrogenase activity
K5K99_11400	COG0395	ABC-type sugar transport system, permease component
K5K99_11405	COG1175	transmembrane transport
K5K99_11410	COG2182	Extracellular solute-binding protein
K5K99_11415	COG0673	inositol 2-dehydrogenase activity
K5K99_11455	COG3493	citrate carrier protein
K5K99_11460	COG3290	protein histidine kinase activity
K5K99_11465	COG4565	transcriptional regulatory protein
K5K99_11480	COG3328	transposase activity
K5K99_11515	COG4372	Transposase
K5K99_11560	COG3328	transposase activity
K5K99_11575	COG1609	Transcriptional regulator
K5K99_11575	COG2207	Transcriptional regulator
K5K99_11580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K99_11625	COG0582	viral genome integration into host DNA
K5K99_11635	COG0719	Fe-S assembly protein
K5K99_11640	COG0822	iron-sulfur transferase activity
K5K99_11645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5K99_11650	COG0719	Fe-S assembly protein
K5K99_11660	COG1464	Belongs to the NlpA lipoprotein family
K5K99_11665	COG2011	ABC-type metal ion transport system permease component
K5K99_11670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K99_11680	COG1937	Protein conserved in bacteria
K5K99_11685	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_11690	COG0488	(ABC) transporter
K5K99_11705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5K99_11710	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K5K99_11720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K99_11725	COG0517	IMP dehydrogenase activity
K5K99_11730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K99_11730	COG0574	Belongs to the PEP-utilizing enzyme family
K5K99_11740	COG1131	(ABC) transporter
K5K99_11760	COG0488	(ABC) transporter
K5K99_11765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_11780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_11795	COG1476	TRANSCRIPTIONal
K5K99_11800	COG1368	sulfuric ester hydrolase activity
K5K99_11805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5K99_11810	COG1660	Displays ATPase and GTPase activities
K5K99_11815	COG0254	rRNA binding
K5K99_11820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5K99_11825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K99_11835	COG1012	belongs to the aldehyde dehydrogenase family
K5K99_11845	COG3343	RNA polymerase activity
K5K99_11860	COG1078	dGTPase activity
K5K99_11865	COG0561	phosphatase activity
K5K99_11875	COG0516	GMP reductase activity
K5K99_11885	COG1131	(ABC) transporter
K5K99_11890	COG4989	oxidoreductase activity
K5K99_11900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K99_11905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_11910	COG3942	CHAP domain
K5K99_11910	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_11935	COG4467	Involved in initiation control of chromosome replication
K5K99_11940	COG1774	PSP1 C-terminal conserved region
K5K99_11945	COG0470	DNA polymerase III
K5K99_11950	COG3870	Protein conserved in bacteria
K5K99_11955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5K99_11960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5K99_11965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5K99_11970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5K99_11975	COG1073	alpha beta
K5K99_11985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5K99_11990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5K99_11995	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5K99_12000	COG1950	PFAM Membrane protein of
K5K99_12015	COG0739	heme binding
K5K99_12015	COG0741	lytic transglycosylase activity
K5K99_12015	COG1196	nuclear chromosome segregation
K5K99_12020	COG0704	Plays a role in the regulation of phosphate uptake
K5K99_12025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K99_12030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K99_12035	COG0581	inorganic phosphate transmembrane transporter activity
K5K99_12040	COG0573	inorganic phosphate transmembrane transporter activity
K5K99_12055	COG2177	Part of the ABC transporter FtsEX involved in
K5K99_12060	COG2884	Cell division ATP-binding protein ftsE
K5K99_12070	COG0653	protein targeting
K5K99_12080	COG1040	competence protein
K5K99_12085	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K5K99_12090	COG2267	carboxylic ester hydrolase activity
K5K99_12100	COG1739	Uncharacterized protein family UPF0029
K5K99_12105	COG2188	Transcriptional regulator
K5K99_12115	COG1309	transcriptional regulator
K5K99_12150	COG0517	IMP dehydrogenase activity
K5K99_12160	COG0411	ABC transporter
K5K99_12170	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5K99_12180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5K99_12190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K99_12205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5K99_12210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5K99_12215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5K99_12220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5K99_12225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K99_12230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5K99_12235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K99_12240	COG0356	it plays a direct role in the translocation of protons across the membrane
K5K99_12245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5K99_12250	COG0557	exoribonuclease II activity
K5K99_12265	COG3397	chitin binding
K5K99_12270	COG1942	4-Oxalocrotonate Tautomerase
K5K99_12310	COG2378	regulation of single-species biofilm formation
K5K99_12325	COG0716	FMN binding
K5K99_12345	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K5K99_12365	COG0590	tRNA wobble adenosine to inosine editing
K5K99_12375	COG0666	response to abiotic stimulus
K5K99_12385	COG2508	Transcriptional regulator
K5K99_12395	COG1132	(ABC) transporter
K5K99_12400	COG4988	ABC transporter
K5K99_12410	COG1288	antiporter activity
K5K99_12415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_12425	COG1609	Transcriptional regulator
K5K99_12435	COG0024	Methionine aminopeptidase
K5K99_12445	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5K99_12450	COG0149	triose-phosphate isomerase activity
K5K99_12455	COG0126	phosphoglycerate kinase activity
K5K99_12465	COG2390	Transcriptional regulator
K5K99_12470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5K99_12480	COG0740	serine-type endopeptidase activity
K5K99_12505	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K99_12510	COG0022	dehydrogenase e1 component
K5K99_12515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K99_12520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K99_12525	COG3284	Transcriptional regulator
K5K99_12530	COG1481	regulation of sporulation
K5K99_12540	COG1660	Displays ATPase and GTPase activities
K5K99_12545	COG2186	Transcriptional regulator
K5K99_12550	COG1131	(ABC) transporter
K5K99_12565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5K99_12570	COG0556	nucleotide-excision repair
K5K99_12575	COG3579	cysteine-type endopeptidase activity
K5K99_12580	COG1316	TRANSCRIPTIONal
K5K99_12585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5K99_12595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5K99_12600	COG2304	oxidoreductase activity
K5K99_12610	COG0714	Associated with various cellular activities
K5K99_12615	COG4716	Myosin-crossreactive antigen
K5K99_12630	COG2608	mercury ion transmembrane transporter activity
K5K99_12635	COG2723	6-phospho-beta-galactosidase activity
K5K99_12640	COG1263	PTS System
K5K99_12640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_12640	COG2190	(PTS) system
K5K99_12645	COG3711	transcriptional antiterminator
K5K99_12655	COG0436	Aminotransferase
K5K99_12665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5K99_12665	COG1199	ATP-dependent helicase activity
K5K99_12675	COG2246	polysaccharide biosynthetic process
K5K99_12725	COG1098	S1 RNA binding domain
K5K99_12730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K99_12735	COG0572	uridine kinase
K5K99_12740	COG4619	ABC transporter
K5K99_12745	COG0390	transport system, permease component
K5K99_12755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_12760	COG2188	Transcriptional regulator
K5K99_12765	COG1446	asparaginase
K5K99_12785	COG4608	Belongs to the ABC transporter superfamily
K5K99_12790	COG0444	Belongs to the ABC transporter superfamily
K5K99_12795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K99_12800	COG0601	transmembrane transport
K5K99_12810	COG4166	transmembrane transport
K5K99_12820	COG3716	PTS system mannose fructose sorbose family IID component
K5K99_12825	COG3715	PTS system
K5K99_12835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_12835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_12840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K99_12840	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K99_12855	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K99_12860	COG4166	transmembrane transport
K5K99_12865	COG4166	transmembrane transport
K5K99_12870	COG4166	transmembrane transport
K5K99_12880	COG4948	Mandelate Racemase Muconate Lactonizing
K5K99_12895	COG2723	6-phospho-beta-galactosidase activity
K5K99_12900	COG0371	Dehydrogenase
K5K99_12905	COG0765	amino acid transport
K5K99_12910	COG1126	abc transporter atp-binding protein
K5K99_12915	COG0436	Aminotransferase
K5K99_12925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K5K99_12930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5K99_12940	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K5K99_12945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5K99_12950	COG1196	nuclear chromosome segregation
K5K99_12950	COG0741	lytic transglycosylase activity
K5K99_12950	COG0739	heme binding
K5K99_12955	COG3942	CHAP domain
K5K99_12955	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_12970	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_12975	COG2514	catechol 2,3-dioxygenase activity
K5K99_12990	COG2217	Heavy metal translocating P-type atpase
K5K99_13000	COG5002	protein histidine kinase activity
K5K99_13005	COG0745	RESPONSE REGULATOR receiver
K5K99_13010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K99_13015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5K99_13020	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5K99_13030	COG4703	Protein of unknown function (DUF1797)
K5K99_13035	COG2084	Dehydrogenase
K5K99_13045	COG0438	transferase activity, transferring glycosyl groups
K5K99_13050	COG0438	transferase activity, transferring glycosyl groups
K5K99_13055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K99_13070	COG0542	response to heat
K5K99_13080	COG0463	Glycosyl transferase, family 2
K5K99_13080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_13090	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5K99_13110	COG1216	Glycosyl transferase, family 2
K5K99_13120	COG0463	Glycosyl transferase, family 2
K5K99_13135	COG1253	flavin adenine dinucleotide binding
K5K99_13140	COG0628	permease
K5K99_13145	COG2153	protein acetylation
K5K99_13160	COG3328	transposase activity
K5K99_13165	COG1215	transferase activity, transferring glycosyl groups
K5K99_13165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_13170	COG3557	Belongs to the UPF0374 family
K5K99_13175	COG1194	a g-specific adenine glycosylase
K5K99_13180	COG2137	regulation of response to DNA damage stimulus
K5K99_13185	COG0583	DNA-binding transcription factor activity
K5K99_13215	COG3328	transposase activity
K5K99_13220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5K99_13255	COG3328	transposase activity
K5K99_13280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5K99_13310	COG0589	response to stress
K5K99_13320	COG1316	TRANSCRIPTIONal
K5K99_13325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K99_13335	COG1216	Glycosyl transferase, family 2
K5K99_13360	COG1086	Polysaccharide biosynthesis protein
K5K99_13365	COG0297	glycogen (starch) synthase activity
K5K99_13385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5K99_13390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5K99_13400	COG4464	protein tyrosine phosphatase activity
K5K99_13405	COG0489	protein tyrosine kinase activity
K5K99_13415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_13420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_13425	COG1682	transport, permease protein
K5K99_13430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K5K99_13435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_13440	COG1134	teichoic acid transport
K5K99_13445	COG1316	TRANSCRIPTIONal
K5K99_13450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K99_13460	COG1295	ribonuclease BN
K5K99_13465	COG0024	Methionine aminopeptidase
K5K99_13470	COG0716	FMN binding
K5K99_13480	COG2309	aminopeptidase activity
K5K99_13485	COG0726	polysaccharide deacetylase
K5K99_13495	COG5002	protein histidine kinase activity
K5K99_13495	COG3850	Histidine kinase
K5K99_13500	COG0745	RESPONSE REGULATOR receiver
K5K99_13510	COG1316	TRANSCRIPTIONal
K5K99_13525	COG1447	Phosphotransferase system cellobiose-specific component IIA
K5K99_13530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_13550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_13560	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K99_13560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K99_13565	COG0513	Belongs to the DEAD box helicase family
K5K99_13585	COG1846	Transcriptional regulator
K5K99_13590	COG1132	(ABC) transporter
K5K99_13605	COG2388	GCN5-related N-acetyl-transferase
K5K99_13610	COG5503	Protein of unknown function (DUF1447)
K5K99_13620	COG1278	Cold shock
K5K99_13625	COG2003	Belongs to the UPF0758 family
K5K99_13630	COG0546	phosphoglycolate phosphatase activity
K5K99_13635	COG0285	dihydrofolate synthase activity
K5K99_13640	COG0525	valine-tRNA ligase activity
K5K99_13650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K99_13655	COG0301	tRNA thio-modification
K5K99_13660	COG1104	cysteine desulfurase activity
K5K99_13665	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K5K99_13670	COG0527	aspartate kinase activity
K5K99_13685	COG0561	phosphatase activity
K5K99_13705	COG3594	Acyltransferase
K5K99_13725	COG3091	SprT-like family
K5K99_13730	COG2183	response to ionizing radiation
K5K99_13740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5K99_13755	COG0681	Belongs to the peptidase S26 family
K5K99_13765	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_13770	COG1876	peptidase activity
K5K99_13780	COG4129	membrane
K5K99_13795	COG0384	phenazine biosynthesis protein PhzF
K5K99_13805	COG0789	Transcriptional regulator
K5K99_13820	COG2268	Band 7 protein
K5K99_13880	COG0436	Aminotransferase
K5K99_13890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5K99_13905	COG1174	glycine betaine transport
K5K99_13915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5K99_13920	COG3599	regulation of cell shape
K5K99_13925	COG2302	S4 RNA-binding domain
K5K99_13935	COG1799	cell septum assembly
K5K99_13940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5K99_13945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5K99_13950	COG0849	cell division
K5K99_13955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5K99_13960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5K99_13965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5K99_13970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K99_13975	COG0768	penicillin binding
K5K99_13985	COG0275	rRNA processing
K5K99_13990	COG2001	Belongs to the MraZ family
K5K99_14005	COG0497	DNA recombination
K5K99_14010	COG1438	arginine binding
K5K99_14015	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K5K99_14025	COG1722	exodeoxyribonuclease VII activity
K5K99_14030	COG1570	exodeoxyribonuclease VII activity
K5K99_14035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5K99_14040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K99_14045	COG1302	Protein conserved in bacteria
K5K99_14050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K99_14055	COG0006	proline dipeptidase activity
K5K99_14135	COG0582	viral genome integration into host DNA
K5K99_14140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5K99_14145	COG2868	ribosomal protein
K5K99_14150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5K99_14165	COG4122	O-methyltransferase activity
K5K99_14170	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K5K99_14175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K5K99_14180	COG0222	ribosome binding
K5K99_14185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5K99_14190	COG0081	regulation of translation
K5K99_14195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5K99_14205	COG2217	Heavy metal translocating P-type atpase
K5K99_14210	COG0673	inositol 2-dehydrogenase activity
K5K99_14230	COG0673	inositol 2-dehydrogenase activity
K5K99_14240	COG1418	mRNA catabolic process
K5K99_14245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5K99_14250	COG1546	Belongs to the CinA family
K5K99_14250	COG1058	Belongs to the CinA family
K5K99_14255	COG1760	l-serine dehydratase
K5K99_14260	COG1760	l-serine dehydratase
K5K99_14275	COG1757	Na H antiporter
K5K99_14285	COG0250	Participates in transcription elongation, termination and antitermination
K5K99_14325	COG1609	Transcriptional regulator
K5K99_14330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5K99_14335	COG0698	ribose 5-phosphate isomerase
K5K99_14340	COG1263	PTS System
K5K99_14340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_14340	COG2190	(PTS) system
K5K99_14375	COG1192	Involved in chromosome partitioning
K5K99_14505	COG0741	lytic transglycosylase activity
K5K99_14505	COG0791	NLP P60 protein
K5K99_14590	COG4684	Psort location CytoplasmicMembrane, score
K5K99_14595	COG0768	penicillin binding