locus-tag	class	description
M2908_00010	COG4129	membrane
M2908_00020	COG1876	peptidase activity
M2908_00025	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2908_00030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M2908_00040	COG4989	oxidoreductase activity
M2908_00045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2908_00050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M2908_00055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2908_00085	COG2183	response to ionizing radiation
M2908_00090	COG3091	SprT-like family
M2908_00105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2908_00110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M2908_00125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2908_00140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M2908_00145	COG0237	dephospho-CoA kinase activity
M2908_00150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M2908_00160	COG1484	DNA-dependent DNA replication
M2908_00170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M2908_00175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M2908_00180	COG0745	RESPONSE REGULATOR receiver
M2908_00185	COG5002	protein histidine kinase activity
M2908_00195	COG0706	membrane insertase activity
M2908_00200	COG1254	Belongs to the acylphosphatase family
M2908_00205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2908_00215	COG1733	regulation of RNA biosynthetic process
M2908_00220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M2908_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_00225	COG0072	phenylalanine-tRNA ligase activity
M2908_00230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M2908_00235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M2908_00240	COG0622	Phosphoesterase
M2908_00250	COG1473	amidohydrolase
M2908_00255	COG0747	negative chemotaxis
M2908_00260	COG0601	transmembrane transport
M2908_00265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2908_00270	COG0444	Belongs to the ABC transporter superfamily
M2908_00275	COG4608	Belongs to the ABC transporter superfamily
M2908_00285	COG0583	DNA-binding transcription factor activity
M2908_00290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2908_00300	COG3052	prosthetic group binding
M2908_00315	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M2908_00315	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
M2908_00320	COG2233	PERMEase
M2908_00325	COG1363	Peptidase, m42
M2908_00330	COG0668	transmembrane transport
M2908_00345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M2908_00355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2908_00360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2908_00370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M2908_00375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M2908_00395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M2908_00405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M2908_00415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M2908_00425	COG1307	EDD domain protein, DegV family
M2908_00430	COG2723	6-phospho-beta-galactosidase activity
M2908_00435	COG2814	Major facilitator Superfamily
M2908_00445	COG0587	DNA-directed DNA polymerase activity
M2908_00450	COG0205	6-phosphofructokinase activity
M2908_00460	COG3409	Peptidoglycan-binding domain 1 protein
M2908_00460	COG0793	Belongs to the peptidase S41A family
M2908_00475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2908_00480	COG0758	DNA mediated transformation
M2908_00485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2908_00490	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M2908_00500	COG4974	Belongs to the 'phage' integrase family
M2908_00505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M2908_00510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M2908_00515	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M2908_00525	COG0686	Belongs to the AlaDH PNT family
M2908_00530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M2908_00540	COG0187	DNA topoisomerase II activity
M2908_00545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M2908_00550	COG0436	Aminotransferase
M2908_00555	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M2908_00560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M2908_00565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M2908_00570	COG0228	four-way junction DNA binding
M2908_00575	COG1837	Belongs to the UPF0109 family
M2908_00580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M2908_00585	COG0336	Belongs to the RNA methyltransferase TrmD family
M2908_00590	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M2908_00595	COG1435	thymidine kinase activity
M2908_00600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M2908_00605	COG2890	protein-(glutamine-N5) methyltransferase activity
M2908_00610	COG0009	L-threonylcarbamoyladenylate synthase
M2908_00615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2908_00620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M2908_00640	COG0772	Belongs to the SEDS family
M2908_00645	COG1393	Belongs to the ArsC family
M2908_00650	COG0509	glycine decarboxylation via glycine cleavage system
M2908_00655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2908_00660	COG2011	ABC-type metal ion transport system permease component
M2908_00665	COG1464	Belongs to the NlpA lipoprotein family
M2908_00680	COG1280	lysine exporter protein (LysE YggA)
M2908_00680	COG1674	ftsk spoiiie
M2908_00695	COG0025	NhaP-type Na H and K H
M2908_00700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M2908_00705	COG1702	phosphate starvation-inducible protein PhoH
M2908_00715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M2908_00720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M2908_00725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2908_00730	COG1381	Involved in DNA repair and RecF pathway recombination
M2908_00735	COG0752	glycyl-tRNA synthetase alpha subunit
M2908_00740	COG0751	glycine-tRNA ligase activity
M2908_00745	COG0358	DNA primase activity
M2908_00750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M2908_00765	COG2384	SAM-dependent methyltransferase
M2908_00770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M2908_00775	COG2195	Cleaves the N-terminal amino acid of tripeptides
M2908_00790	COG0542	response to heat
M2908_00800	COG0481	GTPase activity
M2908_00805	COG4974	Belongs to the 'phage' integrase family
M2908_00855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2908_00865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M2908_00885	COG0779	Required for maturation of 30S ribosomal subunits
M2908_00890	COG0195	Participates in both transcription termination and antitermination
M2908_00895	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M2908_00910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M2908_00915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M2908_00920	COG0196	riboflavin kinase activity
M2908_00925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M2908_00930	COG1420	regulation of RNA biosynthetic process
M2908_00935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M2908_00940	COG0443	Heat shock 70 kDa protein
M2908_00945	COG0484	heat shock protein binding
M2908_00950	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2908_00950	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2908_00955	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M2908_00965	COG1609	Transcriptional regulator
M2908_00975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M2908_00980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M2908_00985	COG3763	UPF0154 protein
M2908_00990	COG1132	(ABC) transporter
M2908_00995	COG1132	(ABC) transporter
M2908_01000	COG0534	Mate efflux family protein
M2908_01005	COG0492	ferredoxin-NADP+ reductase activity
M2908_01010	COG1323	Belongs to the UPF0348 family
M2908_01015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2908_01025	COG2182	Extracellular solute-binding protein
M2908_01045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2908_01050	COG1012	belongs to the aldehyde dehydrogenase family
M2908_01055	COG1136	(ABC) transporter
M2908_01060	COG0577	efflux transmembrane transporter activity
M2908_01065	COG1846	Transcriptional regulator
M2908_01065	COG0456	acetyltransferase
M2908_01090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M2908_01095	COG1694	Mazg nucleotide pyrophosphohydrolase
M2908_01100	COG0617	tRNA 3'-terminal CCA addition
M2908_01115	COG0366	Alpha amylase catalytic
M2908_01120	COG0366	Alpha amylase catalytic
M2908_01125	COG0488	(ABC) transporter
M2908_01130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M2908_01140	COG0367	asparagine synthase
M2908_01145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M2908_01160	COG1272	protein, Hemolysin III
M2908_01165	COG1307	EDD domain protein, DegV family
M2908_01170	COG2755	lipolytic protein G-D-S-L family
M2908_01175	COG4698	Protein conserved in bacteria
M2908_01180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2908_01190	COG0628	permease
M2908_01195	COG2755	lipolytic protein G-D-S-L family
M2908_01195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M2908_01215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2908_01220	COG0765	amino acid transport
M2908_01225	COG0765	amino acid transport
M2908_01235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_01240	COG3711	transcriptional antiterminator
M2908_01255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2908_01260	COG1473	amidohydrolase
M2908_01270	COG0038	chloride channel
M2908_01275	COG5002	protein histidine kinase activity
M2908_01280	COG0745	RESPONSE REGULATOR receiver
M2908_01285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2908_01290	COG0569	domain protein
M2908_01290	COG0475	glutathione-regulated potassium exporter activity
M2908_01305	COG0284	orotidine-5'-phosphate decarboxylase activity
M2908_01315	COG0543	2 iron, 2 sulfur cluster binding
M2908_01320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M2908_01330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M2908_01335	COG0540	Belongs to the ATCase OTCase family
M2908_01350	COG0564	pseudouridine synthase activity
M2908_01355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2908_01370	COG1278	Cold shock
M2908_01380	COG0328	RNA-DNA hybrid ribonuclease activity
M2908_01390	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M2908_01395	COG0116	Belongs to the methyltransferase superfamily
M2908_01410	COG4474	Belongs to the UPF0398 family
M2908_01415	COG3331	DNA recombination
M2908_01420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2908_01425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M2908_01440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_01445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M2908_01445	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M2908_01450	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2908_01450	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2908_01465	COG0300	oxidoreductase activity
M2908_01470	COG1234	tRNA 3'-trailer cleavage
M2908_01475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M2908_01485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2908_01500	COG1012	belongs to the aldehyde dehydrogenase family
M2908_01505	COG1454	alcohol dehydrogenase
M2908_01520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M2908_01525	COG3425	synthase
M2908_01545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2908_01560	COG1304	FMN binding
M2908_01575	COG0039	L-malate dehydrogenase activity
M2908_01585	COG4175	Glycine betaine
M2908_01585	COG3448	diguanylate cyclase activity
M2908_01640	COG1192	Involved in chromosome partitioning
M2908_01665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2908_01665	COG0551	DNA topoisomerase type I activity
M2908_01675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_01695	COG0456	acetyltransferase
M2908_01710	COG0456	acetyltransferase
M2908_01760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2908_01800	COG0149	triose-phosphate isomerase activity
M2908_01805	COG0126	phosphoglycerate kinase activity
M2908_01820	COG5582	Belongs to the UPF0302 family
M2908_01835	COG1160	GTP binding
M2908_01840	COG0539	negative regulation of cytoplasmic translation
M2908_01845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M2908_01855	COG0514	ATP-dependent DNA helicase (RecQ)
M2908_01870	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2908_01875	COG0745	RESPONSE REGULATOR receiver
M2908_01880	COG1187	pseudouridine synthase activity
M2908_01885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M2908_01890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M2908_01895	COG4974	Belongs to the 'phage' integrase family
M2908_01900	COG0735	belongs to the Fur family
M2908_01910	COG2996	Protein conserved in bacteria
M2908_01920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M2908_01925	COG2252	PERMEase
M2908_01935	COG2217	Heavy metal translocating P-type atpase
M2908_01940	COG2608	mercury ion transmembrane transporter activity
M2908_01955	COG0436	Aminotransferase
M2908_01965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M2908_01965	COG1199	ATP-dependent helicase activity
M2908_01980	COG1187	pseudouridine synthase activity
M2908_01985	COG1227	inorganic diphosphatase activity
M2908_01990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M2908_01995	COG1882	Formate acetyltransferase
M2908_02000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2908_02015	COG3684	Belongs to the aldolase LacD family
M2908_02030	COG1349	DNA-binding transcription factor activity
M2908_02045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_02045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_02050	COG1447	Phosphotransferase system cellobiose-specific component IIA
M2908_02055	COG0583	DNA-binding transcription factor activity
M2908_02065	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2908_02070	COG0022	dehydrogenase e1 component
M2908_02075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2908_02080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2908_02085	COG3426	butyrate kinase activity
M2908_02090	COG0280	phosphate acetyltransferase
M2908_02095	COG1073	alpha beta
M2908_02125	COG2151	metal-sulfur cluster biosynthetic enzyme
M2908_02130	COG1073	alpha beta
M2908_02135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_02140	COG1268	BioY protein
M2908_02145	COG2514	catechol 2,3-dioxygenase activity
M2908_02150	COG0335	large ribosomal subunit rRNA binding
M2908_02160	COG0740	serine-type endopeptidase activity
M2908_02165	COG1481	regulation of sporulation
M2908_02170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M2908_02175	COG1660	Displays ATPase and GTPase activities
M2908_02180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M2908_02185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M2908_02190	COG0556	nucleotide-excision repair
M2908_02200	COG1609	Transcriptional regulator
M2908_02205	COG1757	Na H antiporter
M2908_02215	COG2746	aminoglycoside 3-N-acetyltransferase activity
M2908_02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2908_02235	COG3442	glutamine amidotransferase
M2908_02240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_02250	COG1252	NADH dehydrogenase
M2908_02255	COG2814	Major facilitator Superfamily
M2908_02265	COG3158	transport of potassium into the cell
M2908_02275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2908_02290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2908_02290	COG0392	lysyltransferase activity
M2908_02295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2908_02305	COG1486	melibiose metabolic process
M2908_02310	COG1428	Deoxynucleoside kinase
M2908_02325	COG1129	ABC transporter
M2908_02335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2908_02340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M2908_02345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2908_02365	COG0569	domain protein
M2908_02370	COG2197	response regulator
M2908_02375	COG4585	Histidine kinase
M2908_02385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M2908_02390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M2908_02395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2908_02400	COG1126	abc transporter atp-binding protein
M2908_02405	COG0765	amino acid transport
M2908_02410	COG2205	protein histidine kinase activity
M2908_02415	COG0745	RESPONSE REGULATOR receiver
M2908_02420	COG0588	phosphoglycerate mutase activity
M2908_02435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M2908_02445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M2908_02450	COG0456	acetyltransferase
M2908_02460	COG1214	PFAM Peptidase M22, glycoprotease
M2908_02465	COG1609	Transcriptional regulator
M2908_02470	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M2908_02475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M2908_02480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2908_02485	COG0363	glucosamine-6-phosphate deaminase activity
M2908_02495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M2908_02510	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
M2908_02515	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M2908_02520	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
M2908_02525	COG1527	subunit (C
M2908_02535	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2908_02540	COG1269	ATP hydrolysis coupled proton transport
M2908_02550	COG1966	Carbon starvation protein
M2908_02555	COG3279	Response regulator of the LytR AlgR family
M2908_02560	COG3275	phosphorelay sensor kinase activity
M2908_02565	COG0513	Belongs to the DEAD box helicase family
M2908_02575	COG1473	amidohydrolase
M2908_02580	COG1464	Belongs to the NlpA lipoprotein family
M2908_02590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2908_02595	COG1073	alpha beta
M2908_02600	COG2217	Heavy metal translocating P-type atpase
M2908_02605	COG0514	ATP-dependent DNA helicase (RecQ)
M2908_02615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M2908_02620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2908_02640	COG2966	Psort location CytoplasmicMembrane, score
M2908_02645	COG0765	amino acid transport
M2908_02650	COG1126	abc transporter atp-binding protein
M2908_02660	COG0280	phosphate acetyltransferase
M2908_02685	COG0583	DNA-binding transcription factor activity
M2908_02690	COG0825	malonyl-CoA metabolic process
M2908_02695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M2908_02700	COG0439	Biotin carboxylase
M2908_02705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M2908_02715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M2908_02720	COG1028	Short-chain dehydrogenase reductase Sdr
M2908_02725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2908_02735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2908_02740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M2908_02750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2908_02755	COG0351	phosphomethylpyrimidine kinase
M2908_02765	COG0516	GMP reductase activity
M2908_02775	COG2226	methyltransferase
M2908_02780	COG0799	negative regulation of ribosome biogenesis
M2908_02785	COG1713	HD superfamily hydrolase involved in NAD metabolism
M2908_02790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M2908_02795	COG1534	Rna-binding protein
M2908_02800	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M2908_02805	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M2908_02815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M2908_02830	COG0415	Belongs to the DNA photolyase family
M2908_02840	COG0431	NADPH-dependent FMN reductase
M2908_02850	COG0346	lactoylglutathione lyase activity
M2908_02855	COG1846	Transcriptional regulator
M2908_02865	COG0419	ATPase involved in DNA repair
M2908_02870	COG0420	3'-5' exonuclease activity
M2908_02905	COG1473	amidohydrolase
M2908_02915	COG1940	carbohydrate kinase activity
M2908_02945	COG2972	Histidine kinase
M2908_02950	COG2197	response regulator
M2908_02955	COG4209	transmembrane transport
M2908_02965	COG0395	ABC-type sugar transport system, permease component
M2908_02990	COG2723	6-phospho-beta-galactosidase activity
M2908_02995	COG1263	PTS System
M2908_02995	COG2190	(PTS) system
M2908_02995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_03000	COG3711	transcriptional antiterminator
M2908_03025	COG3976	FMN-binding domain protein
M2908_03025	COG0431	NADPH-dependent FMN reductase
M2908_03025	COG1053	succinate dehydrogenase
M2908_03040	COG3104	oligopeptide transport
M2908_03045	COG0450	alkyl hydroperoxide reductase
M2908_03070	COG0346	lactoylglutathione lyase activity
M2908_03075	COG3976	FMN-binding domain protein
M2908_03075	COG1053	succinate dehydrogenase
M2908_03080	COG2972	Histidine kinase
M2908_03085	COG2207	Transcriptional regulator
M2908_03085	COG4753	response regulator
M2908_03105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_03125	COG0488	(ABC) transporter
M2908_03145	COG0149	triose-phosphate isomerase activity
M2908_03150	COG0205	6-phosphofructokinase activity
M2908_03155	COG1609	Transcriptional regulator
M2908_03165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M2908_03170	COG0191	fructose-bisphosphate aldolase activity
M2908_03175	COG0395	ABC-type sugar transport system, permease component
M2908_03180	COG1175	transmembrane transport
M2908_03190	COG1609	Transcriptional regulator
M2908_03195	COG1606	tRNA processing
M2908_03205	COG1691	(AIR) carboxylase
M2908_03220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2908_03225	COG0601	transmembrane transport
M2908_03235	COG0800	Aldolase
M2908_03240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_03275	COG1609	Transcriptional regulator
M2908_03285	COG0822	iron-sulfur transferase activity
M2908_03290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M2908_03295	COG0719	Fe-S assembly protein
M2908_03305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M2908_03320	COG1132	(ABC) transporter
M2908_03325	COG1132	(ABC) transporter
M2908_03330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M2908_03330	COG2207	Transcriptional regulator
M2908_03335	COG0482	sulfurtransferase activity
M2908_03345	COG1104	cysteine desulfurase activity
M2908_03350	COG3594	Acyltransferase
M2908_03355	COG1335	isochorismatase
M2908_03360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2908_03380	COG3853	Toxic anion resistance protein (TelA)
M2908_03385	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2908_03385	COG2918	glutathione biosynthetic process
M2908_03390	COG0552	protein localization to endoplasmic reticulum
M2908_03395	COG0561	phosphatase activity
M2908_03400	COG1196	nuclear chromosome segregation
M2908_03405	COG0571	ribonuclease III activity
M2908_03425	COG0601	transmembrane transport
M2908_03430	COG4608	Belongs to the ABC transporter superfamily
M2908_03440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2908_03445	COG0416	fatty acid biosynthetic process
M2908_03450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M2908_03465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M2908_03470	COG1564	THIamine pyrophosphokinase
M2908_03475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M2908_03480	COG1162	GTPase activity
M2908_03490	COG0785	Cytochrome C biogenesis protein
M2908_03495	COG2815	serine threonine protein kinase
M2908_03495	COG0515	serine threonine protein kinase
M2908_03500	COG0631	protein serine/threonine phosphatase activity
M2908_03505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M2908_03505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2908_03510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M2908_03515	COG0242	peptide deformylase activity
M2908_03520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M2908_03530	COG0194	GDP metabolic process
M2908_03535	COG1561	YicC-like family, N-terminal region
M2908_03540	COG4443	Transcriptional Coactivator p15 (PC4)
M2908_03555	COG0736	holo-[acyl-carrier-protein] synthase activity
M2908_03565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2908_03570	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2908_03580	COG3764	Sortase (surface protein transpeptidase)
M2908_03585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M2908_03590	COG1671	Belongs to the UPF0178 family
M2908_03595	COG0495	leucyl-tRNA aminoacylation
M2908_03600	COG1388	LysM domain
M2908_03600	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2908_03615	COG0671	phosphoesterase, PA-phosphatase related
M2908_03620	COG1242	4 iron, 4 sulfur cluster binding
M2908_03625	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M2908_03630	COG0477	Major facilitator Superfamily
M2908_03635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M2908_03645	COG0222	ribosome binding
M2908_03650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M2908_03655	COG0081	regulation of translation
M2908_03660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M2908_03665	COG1760	l-serine dehydratase
M2908_03670	COG1760	l-serine dehydratase
M2908_03675	COG1396	sequence-specific DNA binding
M2908_03695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2908_03700	COG3123	guanosine phosphorylase activity
M2908_03705	COG0250	Participates in transcription elongation, termination and antitermination
M2908_03715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2908_03725	COG1203	CRISPR-associated helicase, Cas3
M2908_03755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M2908_03760	COG3599	regulation of cell shape
M2908_03765	COG2302	S4 RNA-binding domain
M2908_03775	COG1799	cell septum assembly
M2908_03780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2908_03790	COG0849	cell division
M2908_03800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M2908_03805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M2908_03810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2908_03815	COG0768	penicillin binding
M2908_03825	COG0275	rRNA processing
M2908_03830	COG2001	Belongs to the MraZ family
M2908_03845	COG0497	DNA recombination
M2908_03850	COG1438	arginine binding
M2908_03855	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M2908_03860	COG0142	geranyltranstransferase activity
M2908_03865	COG1722	exodeoxyribonuclease VII activity
M2908_03870	COG1570	exodeoxyribonuclease VII activity
M2908_03875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2908_03880	COG1302	Protein conserved in bacteria
M2908_03885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M2908_03890	COG0006	proline dipeptidase activity
M2908_03895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M2908_03905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M2908_03925	COG0589	response to stress
M2908_03930	COG4106	trans-aconitate 2-methyltransferase activity
M2908_03935	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M2908_03940	COG2017	converts alpha-aldose to the beta-anomer
M2908_03945	COG1388	LysM domain
M2908_03945	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2908_03950	COG0254	rRNA binding
M2908_03955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M2908_03960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2908_03965	COG1686	Belongs to the peptidase S11 family
M2908_03975	COG1132	(ABC) transporter
M2908_03990	COG1114	Component of the transport system for branched-chain amino acids
M2908_03995	COG2608	mercury ion transmembrane transporter activity
M2908_04010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M2908_04030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_04040	COG2226	methyltransferase
M2908_04055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2908_04060	COG1597	lipid kinase activity
M2908_04065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2908_04070	COG0154	amidase activity
M2908_04075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2908_04080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M2908_04085	COG0210	DNA helicase
M2908_04090	COG1668	transmembrane transport
M2908_04095	COG4152	abc transporter atp-binding protein
M2908_04105	COG0322	excinuclease ABC activity
M2908_04185	COG0735	belongs to the Fur family
M2908_04190	COG2176	DNA-directed DNA polymerase activity
M2908_04195	COG0442	prolyl-tRNA aminoacylation
M2908_04200	COG0750	zinc metalloprotease
M2908_04205	COG4589	Belongs to the CDS family
M2908_04210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M2908_04215	COG0038	chloride channel
M2908_04220	COG0233	cytoplasmic translational termination
M2908_04225	COG0528	UMP kinase activity
M2908_04230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M2908_04235	COG0052	Belongs to the universal ribosomal protein uS2 family
M2908_04240	COG2813	Specifically methylates the guanine in position
M2908_04250	COG1607	acyl-coa hydrolase
M2908_04255	COG1072	(Pantothenic acid kinase))
M2908_04260	COG0519	Catalyzes the synthesis of GMP from XMP
M2908_04260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2908_04270	COG0582	viral genome integration into host DNA
M2908_04330	COG0531	amino acid
M2908_04335	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M2908_04340	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2908_04345	COG0022	dehydrogenase e1 component
M2908_04350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2908_04355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2908_04360	COG3284	Transcriptional regulator
M2908_04380	COG0726	polysaccharide deacetylase
M2908_04390	COG1196	nuclear chromosome segregation
M2908_04390	COG0741	lytic transglycosylase activity
M2908_04390	COG0739	heme binding
M2908_04395	COG2723	6-phospho-beta-galactosidase activity
M2908_04400	COG2188	Transcriptional regulator
M2908_04410	COG0789	Transcriptional regulator
M2908_04435	COG1263	PTS System
M2908_04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_04440	COG0366	Alpha amylase catalytic
M2908_04445	COG2188	Transcriptional regulator
M2908_04450	COG1959	2 iron, 2 sulfur cluster binding
M2908_04465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_04470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2908_04485	COG1446	asparaginase
M2908_04490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2908_04495	COG2188	Transcriptional regulator
M2908_04500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_04505	COG4466	Protein conserved in bacteria
M2908_04515	COG1164	Oligoendopeptidase f
M2908_04540	COG1012	belongs to the aldehyde dehydrogenase family
M2908_04540	COG1454	alcohol dehydrogenase
M2908_04550	COG1862	Preprotein translocase
M2908_04555	COG0343	queuine tRNA-ribosyltransferase activity
M2908_04560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M2908_04565	COG2255	four-way junction helicase activity
M2908_04570	COG0632	four-way junction helicase activity
M2908_04580	COG0673	inositol 2-dehydrogenase activity
M2908_04585	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2908_04590	COG1082	Xylose isomerase domain protein TIM barrel
M2908_04595	COG0673	inositol 2-dehydrogenase activity
M2908_04600	COG3962	Belongs to the TPP enzyme family
M2908_04605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_04610	COG3718	enzyme involved in inositol metabolism
M2908_04615	COG1012	belongs to the aldehyde dehydrogenase family
M2908_04620	COG1349	DNA-binding transcription factor activity
M2908_04625	COG1942	4-Oxalocrotonate Tautomerase
M2908_04645	COG4607	ABC-type enterochelin transport system periplasmic component
M2908_04650	COG4604	ABC transporter, ATP-binding protein
M2908_04655	COG4605	iron ion homeostasis
M2908_04660	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2908_04665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2908_04670	COG0827	DNA restriction-modification system
M2908_04675	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2908_04680	COG1803	Methylglyoxal synthase
M2908_04685	COG3842	ATPase activity
M2908_04690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2908_04695	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M2908_04700	COG0084	hydrolase, TatD family'
M2908_04705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_04705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_04710	COG0584	glycerophosphoryl diester phosphodiesterase
M2908_04715	COG0574	Belongs to the PEP-utilizing enzyme family
M2908_04715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2908_04725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M2908_04735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2908_04740	COG0110	maltose O-acetyltransferase activity
M2908_04760	COG0436	Aminotransferase
M2908_04765	COG1174	glycine betaine transport
M2908_04770	COG1732	Glycine betaine
M2908_04800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M2908_04805	COG0673	inositol 2-dehydrogenase activity
M2908_04810	COG1082	Xylose isomerase domain protein TIM barrel
M2908_04820	COG0673	inositol 2-dehydrogenase activity
M2908_04825	COG2207	Transcriptional regulator
M2908_04830	COG1968	undecaprenyl-diphosphatase activity
M2908_04835	COG2217	Heavy metal translocating P-type atpase
M2908_04840	COG1392	Phosphate transport regulator
M2908_04845	COG0306	phosphate transporter
M2908_04850	COG0268	Binds directly to 16S ribosomal RNA
M2908_04855	COG1466	dna polymerase III delta subunit
M2908_04860	COG0658	competence protein
M2908_04860	COG2333	competence protein COMEC
M2908_04865	COG2131	deaminase
M2908_04870	COG1555	photosystem II stabilization
M2908_04870	COG1596	polysaccharide export
M2908_04880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M2908_04885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M2908_04895	COG4717	serine-type aminopeptidase activity
M2908_04905	COG0765	amino acid transport
M2908_04915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M2908_04920	COG4475	Protein of unknown function (DUF436)
M2908_04925	COG1132	(ABC) transporter
M2908_04930	COG1132	(ABC) transporter
M2908_04970	COG4467	Involved in initiation control of chromosome replication
M2908_04975	COG1774	PSP1 C-terminal conserved region
M2908_04980	COG0470	DNA polymerase III
M2908_04985	COG3870	Protein conserved in bacteria
M2908_04990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M2908_04995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M2908_05000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M2908_05005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M2908_05030	COG0590	tRNA wobble adenosine to inosine editing
M2908_05035	COG2508	Transcriptional regulator
M2908_05045	COG2738	Putative neutral zinc metallopeptidase
M2908_05050	COG2824	Alkylphosphonate utilization operon protein PhnA
M2908_05070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M2908_05080	COG0628	permease
M2908_05090	COG2706	6-phosphogluconolactonase activity
M2908_05105	COG0191	fructose-bisphosphate aldolase activity
M2908_05130	COG1217	gtp-binding protein TYPA
M2908_05135	COG0483	inositol monophosphate 1-phosphatase activity
M2908_05140	COG4476	Belongs to the UPF0223 family
M2908_05145	COG3850	Histidine kinase
M2908_05145	COG5002	protein histidine kinase activity
M2908_05150	COG0745	RESPONSE REGULATOR receiver
M2908_05155	COG0561	phosphatase activity
M2908_05165	COG1597	lipid kinase activity
M2908_05170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2908_05175	COG0517	IMP dehydrogenase activity
M2908_05180	COG1346	cytolysis
M2908_05195	COG1418	mRNA catabolic process
M2908_05215	COG0424	maF-like protein
M2908_05225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M2908_05235	COG1692	metallophosphoesterase
M2908_05240	COG1349	DNA-binding transcription factor activity
M2908_05245	COG1105	Belongs to the carbohydrate kinase PfkB family
M2908_05250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2908_05250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_05250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2908_05265	COG1378	Sugar-specific transcriptional regulator TrmB
M2908_05275	COG2094	Belongs to the DNA glycosylase MPG family
M2908_05280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2908_05285	COG1054	Belongs to the UPF0176 family
M2908_05315	COG0383	alpha-mannosidase activity
M2908_05320	COG1979	alcohol dehydrogenase
M2908_05330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2908_05335	COG0156	8-amino-7-oxononanoate synthase activity
M2908_05365	COG1621	beta-fructofuranosidase activity
M2908_05375	COG1609	Transcriptional regulator
M2908_05380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2908_05385	COG1263	PTS System
M2908_05385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_05385	COG2190	(PTS) system
M2908_05390	COG1263	PTS System
M2908_05390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_05395	COG2233	PERMEase
M2908_05400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_05405	COG1733	regulation of RNA biosynthetic process
M2908_05410	COG2910	NAD(P)H-binding
M2908_05420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2908_05440	COG3732	PTS system glucitol sorbitol-specific
M2908_05445	COG3730	PTS system glucitol sorbitol-specific
M2908_05455	COG3711	transcriptional antiterminator
M2908_05455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_05465	COG0583	DNA-binding transcription factor activity
M2908_05475	COG0390	transport system, permease component
M2908_05480	COG4619	ABC transporter
M2908_05490	COG0463	Glycosyl transferase, family 2
M2908_05495	COG2246	polysaccharide biosynthetic process
M2908_05500	COG0737	Belongs to the 5'-nucleotidase family
M2908_05510	COG0402	S-adenosylhomocysteine deaminase activity
M2908_05530	COG1122	ATPase activity
M2908_05535	COG4720	Psort location CytoplasmicMembrane, score
M2908_05570	COG3716	PTS system mannose fructose sorbose family IID component
M2908_05575	COG3715	PTS system
M2908_05585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_05585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_05590	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2908_05590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2908_05595	COG2814	Major facilitator Superfamily
M2908_05600	COG1285	pathogenesis
M2908_05610	COG2723	6-phospho-beta-galactosidase activity
M2908_05615	COG3711	transcriptional antiterminator
M2908_05620	COG1263	PTS System
M2908_05620	COG2190	(PTS) system
M2908_05620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_05630	COG0590	tRNA wobble adenosine to inosine editing
M2908_05640	COG0625	glutathione transferase activity
M2908_05650	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M2908_05655	COG3457	Alanine racemase
M2908_05665	COG2188	Transcriptional regulator
M2908_05670	COG0626	cystathionine gamma-synthase activity
M2908_05695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2908_05700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M2908_05715	COG5002	protein histidine kinase activity
M2908_05720	COG0745	RESPONSE REGULATOR receiver
M2908_05725	COG3973	AAA domain
M2908_05730	COG1737	Transcriptional regulator
M2908_05735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2908_05740	COG1263	PTS System
M2908_05740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_05745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M2908_05760	COG1278	Cold shock
M2908_05780	COG1418	mRNA catabolic process
M2908_05785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M2908_05790	COG1058	Belongs to the CinA family
M2908_05790	COG1546	Belongs to the CinA family
M2908_05795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M2908_05800	COG1426	Protein conserved in bacteria
M2908_05810	COG0612	Peptidase, M16
M2908_05815	COG0612	Peptidase, M16
M2908_05820	COG1970	mechanosensitive ion channel activity
M2908_05825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M2908_05835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_05840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2908_05845	COG1121	(ABC) transporter
M2908_05850	COG1121	(ABC) transporter
M2908_05855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2908_05860	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2908_05870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_05870	COG1263	PTS System
M2908_05870	COG2190	(PTS) system
M2908_05875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M2908_05880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M2908_05885	COG1177	transmembrane transport
M2908_05890	COG1176	ABC-type spermidine putrescine transport system, permease component I
M2908_05895	COG3842	ATPase activity
M2908_05905	COG0604	alcohol dehydrogenase
M2908_05910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M2908_05915	COG0708	Exodeoxyribonuclease III
M2908_05930	COG0737	Belongs to the 5'-nucleotidase family
M2908_05935	COG0802	atpase or kinase
M2908_05940	COG0280	phosphate acetyltransferase
M2908_05945	COG0561	phosphatase activity
M2908_05960	COG0142	geranyltranstransferase activity
M2908_05970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2908_05975	COG4988	ABC transporter
M2908_05980	COG1294	oxidase, subunit
M2908_05985	COG1271	oxidase subunit
M2908_05990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2908_06000	COG0826	peptidase U32
M2908_06010	COG0542	response to heat
M2908_06015	COG4463	regulation of RNA biosynthetic process
M2908_06075	COG0406	alpha-ribazole phosphatase activity
M2908_06090	COG1686	Belongs to the peptidase S11 family
M2908_06095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M2908_06150	COG0516	GMP reductase activity
M2908_06150	COG0517	IMP dehydrogenase activity
M2908_06160	COG0012	GTP binding
M2908_06165	COG4481	Protein conserved in bacteria
M2908_06170	COG1475	DNA binding
M2908_06175	COG1192	Involved in chromosome partitioning
M2908_06180	COG0357	Ribosomal RNA small subunit methyltransferase G
M2908_06195	COG0445	tRNA wobble uridine modification
M2908_06200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2908_06210	COG0706	membrane insertase activity
M2908_06220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M2908_06225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2908_06230	COG0592	DNA-directed DNA polymerase activity
M2908_06235	COG2188	Transcriptional regulator
M2908_06240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M2908_06250	COG3715	PTS system
M2908_06255	COG3716	PTS system mannose fructose sorbose family IID component
M2908_06270	COG5492	domain, Protein
M2908_06275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_06280	COG0800	Aldolase
M2908_06285	COG1414	Transcriptional regulator
M2908_06290	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M2908_06295	COG1028	Short-chain dehydrogenase reductase Sdr
M2908_06310	COG2501	S4 domain
M2908_06315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M2908_06320	COG0187	DNA topoisomerase II activity
M2908_06330	COG0360	Binds together with S18 to 16S ribosomal RNA
M2908_06340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M2908_06345	COG0359	binds to the 23S rRNA
M2908_06350	COG0305	Participates in initiation and elongation during chromosome replication
M2908_06360	COG0488	(ABC) transporter
M2908_06380	COG4939	FMN-binding domain protein
M2908_06400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2908_06405	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2908_06420	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M2908_06425	COG0295	cytidine deaminase activity
M2908_06430	COG1744	ABC transporter substrate-binding protein PnrA-like
M2908_06435	COG3845	ABC transporter
M2908_06440	COG4603	Belongs to the binding-protein-dependent transport system permease family
M2908_06445	COG1079	Belongs to the binding-protein-dependent transport system permease family
M2908_06450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M2908_06455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M2908_06460	COG0813	purine-nucleoside phosphorylase activity
M2908_06465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M2908_06470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M2908_06475	COG0049	tRNA binding
M2908_06480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2908_06485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M2908_06495	COG0051	transcription antitermination factor activity, RNA binding
M2908_06500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M2908_06505	COG0088	Forms part of the polypeptide exit tunnel
M2908_06510	COG0089	rRNA binding
M2908_06515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M2908_06525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M2908_06530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M2908_06535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M2908_06540	COG0255	Belongs to the universal ribosomal protein uL29 family
M2908_06545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M2908_06550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M2908_06555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M2908_06560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M2908_06565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M2908_06570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M2908_06575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M2908_06585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M2908_06590	COG1841	ribosomal large subunit assembly
M2908_06595	COG0200	Binds to the 23S rRNA
M2908_06600	COG0201	protein transport
M2908_06605	COG0563	adenylate kinase activity
M2908_06615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M2908_06620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M2908_06625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M2908_06630	COG0202	RNA polymerase activity
M2908_06635	COG0203	ribosomal protein L17
M2908_06640	COG1122	ATPase activity
M2908_06645	COG1122	ATPase activity
M2908_06655	COG0101	tRNA pseudouridine synthase activity
M2908_06660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M2908_06665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M2908_06680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M2908_06700	COG1401	restriction endodeoxyribonuclease activity
M2908_06785	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M2908_06790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2908_06810	COG3973	AAA domain
M2908_06820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2908_06835	COG2003	Belongs to the UPF0758 family
M2908_06845	COG0477	Major facilitator Superfamily
M2908_06855	COG0488	(ABC) transporter
M2908_06870	COG3291	Pkd domain containing protein
M2908_06870	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M2908_06885	COG0456	acetyltransferase
M2908_06890	COG2723	6-phospho-beta-galactosidase activity
M2908_06920	COG4209	transmembrane transport
M2908_06925	COG0395	ABC-type sugar transport system, permease component
M2908_06940	COG1482	cell wall glycoprotein biosynthetic process
M2908_06955	COG2076	Multidrug Resistance protein
M2908_06960	COG2076	Multidrug Resistance protein
M2908_06965	COG3859	Proton-coupled thiamine transporter YuaJ
M2908_06980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_06995	COG3579	cysteine-type endopeptidase activity
M2908_07015	COG3639	organic phosphonate transmembrane transporter activity
M2908_07020	COG0737	Belongs to the 5'-nucleotidase family
M2908_07025	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2908_07030	COG0589	response to stress
M2908_07045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M2908_07055	COG2264	protein methyltransferase activity
M2908_07060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M2908_07085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2908_07090	COG1490	D-aminoacyl-tRNA deacylase activity
M2908_07095	COG0860	N-Acetylmuramoyl-L-alanine amidase
M2908_07095	COG3103	Sh3 type 3 domain protein
M2908_07095	COG4991	sh3 domain protein
M2908_07100	COG0124	histidyl-tRNA synthetase
M2908_07105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M2908_07110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_07115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2908_07130	COG1605	Chorismate mutase
M2908_07130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M2908_07135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2908_07140	COG4493	Belongs to the UPF0637 family
M2908_07150	COG1363	Peptidase, m42
M2908_07155	COG2244	polysaccharide biosynthetic process
M2908_07160	COG1187	pseudouridine synthase activity
M2908_07170	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2908_07175	COG1937	Protein conserved in bacteria
M2908_07180	COG0756	dUTP diphosphatase activity
M2908_07190	COG4956	integral membrane protein (PIN domain superfamily)
M2908_07195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2908_07200	COG1045	serine acetyltransferase
M2908_07205	COG0215	cysteine-tRNA ligase activity
M2908_07210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M2908_07220	COG3688	RNA-binding protein containing a PIN domain
M2908_07230	COG0217	transcriptional regulatory protein
M2908_07235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M2908_07240	COG1459	type II secretion system
M2908_07300	COG1484	DNA-dependent DNA replication
M2908_07390	COG2369	cell adhesion
M2908_07505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M2908_07510	COG0572	uridine kinase
M2908_07540	COG2249	NAD(P)H dehydrogenase (quinone) activity
M2908_07550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M2908_07555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M2908_07560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M2908_07565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M2908_07570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M2908_07575	COG1328	CTP reductase activity
M2908_07585	COG1363	Peptidase, m42
M2908_07590	COG1234	tRNA 3'-trailer cleavage
M2908_07595	COG0095	Lipoate-protein ligase
M2908_07600	COG0180	Tryptophanyl-tRNA synthetase
M2908_07605	COG1393	Belongs to the ArsC family
M2908_07610	COG4862	establishment of competence for transformation
M2908_07615	COG4684	Psort location CytoplasmicMembrane, score
M2908_07620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2908_07625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2908_07635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2908_07640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2908_07645	COG1780	Probably involved in ribonucleotide reductase function
M2908_07650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M2908_07660	COG0193	aminoacyl-tRNA hydrolase activity
M2908_07665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M2908_07670	COG2244	polysaccharide biosynthetic process
M2908_07675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M2908_07685	COG1098	S1 RNA binding domain
M2908_07690	COG0037	tRNA processing
M2908_07695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M2908_07700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2908_07705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M2908_07710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2908_07715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M2908_07860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2908_07880	COG0577	efflux transmembrane transporter activity
M2908_07885	COG1136	(ABC) transporter
M2908_07890	COG0183	Belongs to the thiolase family
M2908_07895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M2908_07900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M2908_07910	COG0450	alkyl hydroperoxide reductase
M2908_07915	COG3634	alkyl hydroperoxide reductase activity
M2908_07920	COG2390	Transcriptional regulator
M2908_07935	COG0494	nUDIX hydrolase
M2908_07945	COG1309	transcriptional regulator
M2908_07950	COG2376	Dihydroxyacetone kinase
M2908_07960	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M2908_07965	COG1461	Dihydroxyacetone kinase
M2908_07970	COG2376	Dihydroxyacetone kinase
M2908_07975	COG1288	antiporter activity
M2908_07980	COG1959	2 iron, 2 sulfur cluster binding
M2908_08005	COG2827	Endonuclease containing a URI domain
M2908_08010	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M2908_08015	COG0204	Acyl-transferase
M2908_08020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2908_08025	COG1132	(ABC) transporter
M2908_08035	COG2814	Major facilitator Superfamily
M2908_08040	COG4109	DRTGG domain
M2908_08045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M2908_08055	COG1609	Transcriptional regulator
M2908_08060	COG0488	(ABC) transporter
M2908_08065	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2908_08070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M2908_08075	COG0459	protein refolding
M2908_08080	COG2972	Histidine kinase
M2908_08095	COG3842	ATPase activity
M2908_08105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M2908_08110	COG0656	L-ascorbic acid biosynthetic process
M2908_08115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_08115	COG1263	PTS System
M2908_08120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M2908_08125	COG0281	malic enzyme
M2908_08130	COG0114	fumarate hydratase activity
M2908_08135	COG1737	Transcriptional regulator
M2908_08140	COG0737	Belongs to the 5'-nucleotidase family
M2908_08150	COG2207	Transcriptional regulator
M2908_08160	COG0242	peptide deformylase activity
M2908_08165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M2908_08170	COG1185	polyribonucleotide nucleotidyltransferase activity
M2908_08175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M2908_08180	COG0768	penicillin binding
M2908_08185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2908_08195	COG0457	Tetratricopeptide repeat
M2908_08195	COG0705	Rhomboid family
M2908_08200	COG1940	carbohydrate kinase activity
M2908_08205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M2908_08215	COG5503	Protein of unknown function (DUF1447)
M2908_08225	COG1132	(ABC) transporter
M2908_08235	COG0673	inositol 2-dehydrogenase activity
M2908_08245	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2908_08245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2908_08250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_08260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_08285	COG2309	aminopeptidase activity
M2908_08295	COG0716	FMN binding
M2908_08300	COG0024	Methionine aminopeptidase
M2908_08305	COG1295	ribonuclease BN
M2908_08310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2908_08315	COG1316	TRANSCRIPTIONal
M2908_08320	COG1134	teichoic acid transport
M2908_08325	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_08330	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M2908_08335	COG1682	transport, permease protein
M2908_08340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_08345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2908_08350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_08350	COG0463	Glycosyl transferase, family 2
M2908_08355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2908_08360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_08360	COG0463	Glycosyl transferase, family 2
M2908_08390	COG3944	biosynthesis protein
M2908_08395	COG0489	protein tyrosine kinase activity
M2908_08400	COG4464	protein tyrosine phosphatase activity
M2908_08410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M2908_08425	COG1086	Polysaccharide biosynthesis protein
M2908_08455	COG1442	glycosyl transferase family 8
M2908_08470	COG0686	Belongs to the AlaDH PNT family
M2908_08480	COG1316	TRANSCRIPTIONal
M2908_08485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M2908_08495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M2908_08525	COG2137	regulation of response to DNA damage stimulus
M2908_08530	COG1194	a g-specific adenine glycosylase
M2908_08535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2908_08535	COG0392	lysyltransferase activity
M2908_08555	COG3764	Sortase (surface protein transpeptidase)
M2908_08575	COG3557	Belongs to the UPF0374 family
M2908_08595	COG0628	permease
M2908_08600	COG1253	flavin adenine dinucleotide binding
M2908_08615	COG1609	Transcriptional regulator
M2908_08620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_08630	COG1129	ABC transporter
M2908_08635	COG1172	Belongs to the binding-protein-dependent transport system permease family
M2908_08640	COG1879	ABC-type sugar transport system periplasmic component
M2908_08645	COG1278	Cold shock
M2908_08655	COG1136	(ABC) transporter
M2908_08655	COG0577	efflux transmembrane transporter activity
M2908_08660	COG1136	(ABC) transporter
M2908_08660	COG0577	efflux transmembrane transporter activity
M2908_08665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2908_08670	COG0640	Transcriptional regulator
M2908_08675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M2908_08685	COG4116	CYTH
M2908_08690	COG2357	RelA SpoT domain protein
M2908_08695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M2908_08700	COG0564	pseudouridine synthase activity
M2908_08705	COG2239	Acts as a magnesium transporter
M2908_08710	COG3142	Participates in the control of copper homeostasis
M2908_08715	COG0500	methyltransferase
M2908_08725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M2908_08730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M2908_08735	COG1368	sulfuric ester hydrolase activity
M2908_08745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2908_08750	COG0765	amino acid transport
M2908_08760	COG1368	sulfuric ester hydrolase activity
M2908_08765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M2908_08775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2908_08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2908_08800	COG2081	HI0933 family
M2908_08805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2908_08810	COG0166	Belongs to the GPI family
M2908_08825	COG1801	Protein of unknown function DUF72
M2908_08830	COG0561	phosphatase activity
M2908_08835	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M2908_08840	COG1104	cysteine desulfurase activity
M2908_08850	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2908_08855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M2908_08860	COG0525	valine-tRNA ligase activity
M2908_08865	COG0285	dihydrofolate synthase activity
M2908_08870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2908_08875	COG2003	Belongs to the UPF0758 family
M2908_08880	COG1278	Cold shock
M2908_08890	COG0584	glycerophosphoryl diester phosphodiesterase
M2908_08895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M2908_08900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M2908_08905	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M2908_08915	COG0542	response to heat
M2908_08925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_08930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2908_08935	COG0438	transferase activity, transferring glycosyl groups
M2908_08940	COG0438	transferase activity, transferring glycosyl groups
M2908_08950	COG2084	Dehydrogenase
M2908_08955	COG2188	Transcriptional regulator
M2908_08960	COG2222	sugar isomerase
M2908_08965	COG3684	Belongs to the aldolase LacD family
M2908_08970	COG1105	Belongs to the carbohydrate kinase PfkB family
M2908_08975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_08985	COG3716	PTS system mannose fructose sorbose family IID component
M2908_08990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_09000	COG4703	Protein of unknown function (DUF1797)
M2908_09010	COG1714	RDD family
M2908_09020	COG0544	peptidyl-prolyl cis-trans isomerase activity
M2908_09025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M2908_09035	COG0351	phosphomethylpyrimidine kinase
M2908_09040	COG0352	thiamine-phosphate diphosphorylase activity
M2908_09050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M2908_09050	COG1116	anion transmembrane transporter activity
M2908_09055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2908_09060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M2908_09065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M2908_09075	COG2011	ABC-type metal ion transport system permease component
M2908_09080	COG1464	Belongs to the NlpA lipoprotein family
M2908_09085	COG2116	formate transmembrane transporter activity
M2908_09145	COG0791	NLP P60 protein
M2908_09145	COG0741	lytic transglycosylase activity
M2908_09175	COG2946	Replication initiation factor
M2908_09185	COG1674	ftsk spoiiie
M2908_09200	COG4838	Belongs to the UPF0358 family
M2908_09205	COG0772	Belongs to the SEDS family
M2908_09210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M2908_09225	COG4471	UPF0298 protein
M2908_09230	COG0742	ribosomal rna small subunit methyltransferase
M2908_09235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M2908_09240	COG3480	Lon protease (S16) C-terminal proteolytic domain
M2908_09245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M2908_09250	COG1597	lipid kinase activity
M2908_09255	COG0583	DNA-binding transcription factor activity
M2908_09260	COG2391	methyltransferase activity
M2908_09265	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2908_09270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2908_09275	COG4521	taurine ABC transporter
M2908_09280	COG1116	anion transmembrane transporter activity
M2908_09290	COG4708	membrane
M2908_09295	COG0018	arginyl-trna synthetase
M2908_09300	COG1438	arginine binding
M2908_09310	COG0564	pseudouridine synthase activity
M2908_09315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2908_09320	COG3679	Belongs to the UPF0342 family
M2908_09325	COG3481	metal-dependent phosphohydrolase, HD sub domain
M2908_09330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2908_09340	COG0537	adenosine 5'-monophosphoramidase activity
M2908_09345	COG1131	(ABC) transporter
M2908_09355	COG0510	thiamine kinase activity
M2908_09360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2908_09375	COG1486	melibiose metabolic process
M2908_09385	COG1363	Peptidase, m42
M2908_09390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2908_09395	COG0589	response to stress
M2908_09400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_09405	COG4472	Bacterial protein of unknown function (DUF965)
M2908_09415	COG3906	Belongs to the UPF0473 family
M2908_09430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2908_09440	COG5294	Protein conserved in bacteria
M2908_09445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2908_09460	COG1193	negative regulation of DNA recombination
M2908_09465	COG3118	belongs to the thioredoxin family
M2908_09485	COG0601	transmembrane transport
M2908_09490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2908_09495	COG0444	Belongs to the ABC transporter superfamily
M2908_09500	COG4608	Belongs to the ABC transporter superfamily
M2908_09505	COG4166	transmembrane transport
M2908_09520	COG2365	Tyrosine phosphatase family
M2908_09530	COG4470	Protein conserved in bacteria
M2908_09535	COG0647	UMP catabolic process
M2908_09545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M2908_09550	COG0492	ferredoxin-NADP+ reductase activity
M2908_09560	COG1098	S1 RNA binding domain
M2908_09605	COG2261	transglycosylase associated protein
M2908_09625	COG0709	Synthesizes selenophosphate from selenide and ATP
M2908_09645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M2908_09655	COG0557	exoribonuclease II activity
M2908_09660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M2908_09665	COG0356	it plays a direct role in the translocation of protons across the membrane
M2908_09670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2908_09675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M2908_09680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2908_09685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M2908_09690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M2908_09695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M2908_09700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M2908_09710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2908_09720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2908_09755	COG0517	IMP dehydrogenase activity
M2908_09785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M2908_09790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M2908_09795	COG0546	phosphoglycolate phosphatase activity
M2908_09800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M2908_09810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M2908_09815	COG4224	UPF0291 protein
M2908_09825	COG0681	Belongs to the peptidase S26 family
M2908_09830	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M2908_09835	COG1074	ATP-dependent DNA helicase activity
M2908_09840	COG2188	Transcriptional regulator
M2908_09845	COG1739	Uncharacterized protein family UPF0029
M2908_09855	COG2267	carboxylic ester hydrolase activity
M2908_09860	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M2908_09875	COG0653	protein targeting
M2908_09885	COG2884	Cell division ATP-binding protein ftsE
M2908_09890	COG2177	Part of the ABC transporter FtsEX involved in
M2908_09895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2908_09900	COG0573	inorganic phosphate transmembrane transporter activity
M2908_09905	COG0581	inorganic phosphate transmembrane transporter activity
M2908_09910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2908_09915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2908_09970	COG1950	PFAM Membrane protein of
M2908_09975	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M2908_09990	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2908_09995	COG1122	ATPase activity
M2908_10000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2908_10005	COG0735	belongs to the Fur family
M2908_10015	COG1610	YqeY-like protein
M2908_10040	COG0095	Lipoate-protein ligase
M2908_10050	COG3343	RNA polymerase activity
M2908_10080	COG2268	Band 7 protein