locus-tag	class	description
M2909_00040	COG3448	diguanylate cyclase activity
M2909_00040	COG4175	Glycine betaine
M2909_00050	COG0039	L-malate dehydrogenase activity
M2909_00065	COG1304	FMN binding
M2909_00080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2909_00100	COG3425	synthase
M2909_00105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M2909_00120	COG1454	alcohol dehydrogenase
M2909_00125	COG1012	belongs to the aldehyde dehydrogenase family
M2909_00140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2909_00150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M2909_00155	COG1234	tRNA 3'-trailer cleavage
M2909_00160	COG0300	oxidoreductase activity
M2909_00175	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2909_00175	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2909_00180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M2909_00180	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M2909_00185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2909_00200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M2909_00205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2909_00210	COG3331	DNA recombination
M2909_00215	COG4474	Belongs to the UPF0398 family
M2909_00230	COG0116	Belongs to the methyltransferase superfamily
M2909_00235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M2909_00245	COG0328	RNA-DNA hybrid ribonuclease activity
M2909_00255	COG1278	Cold shock
M2909_00270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2909_00275	COG0564	pseudouridine synthase activity
M2909_00290	COG0540	Belongs to the ATCase OTCase family
M2909_00295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M2909_00305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M2909_00310	COG0543	2 iron, 2 sulfur cluster binding
M2909_00320	COG0284	orotidine-5'-phosphate decarboxylase activity
M2909_00335	COG0475	glutathione-regulated potassium exporter activity
M2909_00335	COG0569	domain protein
M2909_00340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2909_00345	COG0745	RESPONSE REGULATOR receiver
M2909_00350	COG5002	protein histidine kinase activity
M2909_00355	COG0038	chloride channel
M2909_00365	COG1473	amidohydrolase
M2909_00370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2909_00385	COG3711	transcriptional antiterminator
M2909_00390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2909_00400	COG0765	amino acid transport
M2909_00405	COG0765	amino acid transport
M2909_00410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2909_00430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M2909_00430	COG2755	lipolytic protein G-D-S-L family
M2909_00435	COG0628	permease
M2909_00445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2909_00450	COG4698	Protein conserved in bacteria
M2909_00455	COG2755	lipolytic protein G-D-S-L family
M2909_00460	COG1307	EDD domain protein, DegV family
M2909_00465	COG1272	protein, Hemolysin III
M2909_00480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M2909_00485	COG0367	asparagine synthase
M2909_00495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M2909_00500	COG0488	(ABC) transporter
M2909_00505	COG0366	Alpha amylase catalytic
M2909_00510	COG0366	Alpha amylase catalytic
M2909_00525	COG0617	tRNA 3'-terminal CCA addition
M2909_00530	COG1694	Mazg nucleotide pyrophosphohydrolase
M2909_00535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M2909_00560	COG0456	acetyltransferase
M2909_00560	COG1846	Transcriptional regulator
M2909_00565	COG0577	efflux transmembrane transporter activity
M2909_00570	COG1136	(ABC) transporter
M2909_00575	COG1012	belongs to the aldehyde dehydrogenase family
M2909_00580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2909_00600	COG2182	Extracellular solute-binding protein
M2909_00610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2909_00615	COG1323	Belongs to the UPF0348 family
M2909_00620	COG0492	ferredoxin-NADP+ reductase activity
M2909_00625	COG0534	Mate efflux family protein
M2909_00630	COG1132	(ABC) transporter
M2909_00635	COG1132	(ABC) transporter
M2909_00640	COG3763	UPF0154 protein
M2909_00645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M2909_00650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M2909_00660	COG1609	Transcriptional regulator
M2909_00670	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M2909_00675	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2909_00675	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2909_00680	COG0484	heat shock protein binding
M2909_00685	COG0443	Heat shock 70 kDa protein
M2909_00690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M2909_00695	COG1420	regulation of RNA biosynthetic process
M2909_00700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M2909_00705	COG0196	riboflavin kinase activity
M2909_00710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M2909_00715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M2909_00730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M2909_00735	COG0195	Participates in both transcription termination and antitermination
M2909_00740	COG0779	Required for maturation of 30S ribosomal subunits
M2909_00760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M2909_00770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2909_00820	COG4974	Belongs to the 'phage' integrase family
M2909_00825	COG0481	GTPase activity
M2909_00835	COG0542	response to heat
M2909_00850	COG2195	Cleaves the N-terminal amino acid of tripeptides
M2909_00855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M2909_00860	COG2384	SAM-dependent methyltransferase
M2909_00875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M2909_00880	COG0358	DNA primase activity
M2909_00885	COG0751	glycine-tRNA ligase activity
M2909_00890	COG0752	glycyl-tRNA synthetase alpha subunit
M2909_00895	COG1381	Involved in DNA repair and RecF pathway recombination
M2909_00900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2909_00905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M2909_00910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M2909_00920	COG1702	phosphate starvation-inducible protein PhoH
M2909_00925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M2909_00930	COG0025	NhaP-type Na H and K H
M2909_00945	COG1280	lysine exporter protein (LysE YggA)
M2909_00945	COG1674	ftsk spoiiie
M2909_00960	COG1464	Belongs to the NlpA lipoprotein family
M2909_00965	COG2011	ABC-type metal ion transport system permease component
M2909_00970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2909_00975	COG0509	glycine decarboxylation via glycine cleavage system
M2909_00980	COG1393	Belongs to the ArsC family
M2909_00985	COG0772	Belongs to the SEDS family
M2909_01005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M2909_01010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2909_01015	COG0009	L-threonylcarbamoyladenylate synthase
M2909_01020	COG2890	protein-(glutamine-N5) methyltransferase activity
M2909_01025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M2909_01030	COG1435	thymidine kinase activity
M2909_01035	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M2909_01040	COG0336	Belongs to the RNA methyltransferase TrmD family
M2909_01045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M2909_01050	COG1837	Belongs to the UPF0109 family
M2909_01055	COG0228	four-way junction DNA binding
M2909_01060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M2909_01065	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M2909_01070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M2909_01075	COG0436	Aminotransferase
M2909_01080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M2909_01085	COG0187	DNA topoisomerase II activity
M2909_01095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M2909_01100	COG0686	Belongs to the AlaDH PNT family
M2909_01110	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M2909_01115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M2909_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M2909_01125	COG4974	Belongs to the 'phage' integrase family
M2909_01135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M2909_01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2909_01145	COG0758	DNA mediated transformation
M2909_01150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2909_01165	COG3409	Peptidoglycan-binding domain 1 protein
M2909_01165	COG0793	Belongs to the peptidase S41A family
M2909_01175	COG0205	6-phosphofructokinase activity
M2909_01180	COG0587	DNA-directed DNA polymerase activity
M2909_01190	COG2814	Major facilitator Superfamily
M2909_01195	COG2723	6-phospho-beta-galactosidase activity
M2909_01200	COG1307	EDD domain protein, DegV family
M2909_01210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M2909_01220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M2909_01230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M2909_01250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M2909_01255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M2909_01265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2909_01270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2909_01280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M2909_01295	COG0668	transmembrane transport
M2909_01300	COG1363	Peptidase, m42
M2909_01305	COG2233	PERMEase
M2909_01310	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
M2909_01310	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M2909_01325	COG3052	prosthetic group binding
M2909_01335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2909_01340	COG0583	DNA-binding transcription factor activity
M2909_01350	COG4608	Belongs to the ABC transporter superfamily
M2909_01355	COG0444	Belongs to the ABC transporter superfamily
M2909_01360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2909_01365	COG0601	transmembrane transport
M2909_01370	COG0747	negative chemotaxis
M2909_01375	COG1473	amidohydrolase
M2909_01385	COG0622	Phosphoesterase
M2909_01390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M2909_01395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M2909_01400	COG0072	phenylalanine-tRNA ligase activity
M2909_01400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2909_01405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M2909_01410	COG1733	regulation of RNA biosynthetic process
M2909_01420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2909_01425	COG1254	Belongs to the acylphosphatase family
M2909_01430	COG0706	membrane insertase activity
M2909_01440	COG5002	protein histidine kinase activity
M2909_01445	COG0745	RESPONSE REGULATOR receiver
M2909_01450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M2909_01455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M2909_01465	COG1484	DNA-dependent DNA replication
M2909_01475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M2909_01480	COG0237	dephospho-CoA kinase activity
M2909_01485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M2909_01500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2909_01515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M2909_01520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2909_01535	COG3091	SprT-like family
M2909_01540	COG2183	response to ionizing radiation
M2909_01570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2909_01575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M2909_01580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2909_01585	COG4989	oxidoreductase activity
M2909_01595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M2909_01600	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2909_01605	COG1876	peptidase activity
M2909_01615	COG4129	membrane
M2909_01630	COG2268	Band 7 protein
M2909_01660	COG3343	RNA polymerase activity
M2909_01670	COG0095	Lipoate-protein ligase
M2909_01695	COG1610	YqeY-like protein
M2909_01705	COG0735	belongs to the Fur family
M2909_01710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2909_01715	COG1122	ATPase activity
M2909_01720	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2909_01735	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M2909_01740	COG1950	PFAM Membrane protein of
M2909_01795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2909_01800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2909_01805	COG0581	inorganic phosphate transmembrane transporter activity
M2909_01810	COG0573	inorganic phosphate transmembrane transporter activity
M2909_01815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2909_01820	COG2177	Part of the ABC transporter FtsEX involved in
M2909_01825	COG2884	Cell division ATP-binding protein ftsE
M2909_01835	COG0653	protein targeting
M2909_01850	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M2909_01855	COG2267	carboxylic ester hydrolase activity
M2909_01865	COG1739	Uncharacterized protein family UPF0029
M2909_01870	COG2188	Transcriptional regulator
M2909_01875	COG1074	ATP-dependent DNA helicase activity
M2909_01880	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M2909_01885	COG0681	Belongs to the peptidase S26 family
M2909_01895	COG4224	UPF0291 protein
M2909_01900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M2909_01910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M2909_01915	COG0546	phosphoglycolate phosphatase activity
M2909_01920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M2909_01925	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M2909_01955	COG0517	IMP dehydrogenase activity
M2909_01990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2909_02000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2909_02010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M2909_02015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M2909_02020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M2909_02025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M2909_02030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2909_02035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M2909_02040	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2909_02045	COG0356	it plays a direct role in the translocation of protons across the membrane
M2909_02050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M2909_02055	COG0557	exoribonuclease II activity
M2909_02065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M2909_02085	COG0709	Synthesizes selenophosphate from selenide and ATP
M2909_02105	COG2261	transglycosylase associated protein
M2909_02150	COG1098	S1 RNA binding domain
M2909_02160	COG0492	ferredoxin-NADP+ reductase activity
M2909_02165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M2909_02175	COG0647	UMP catabolic process
M2909_02180	COG4470	Protein conserved in bacteria
M2909_02190	COG2365	Tyrosine phosphatase family
M2909_02205	COG4166	transmembrane transport
M2909_02210	COG4608	Belongs to the ABC transporter superfamily
M2909_02215	COG0444	Belongs to the ABC transporter superfamily
M2909_02220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2909_02225	COG0601	transmembrane transport
M2909_02245	COG3118	belongs to the thioredoxin family
M2909_02250	COG1193	negative regulation of DNA recombination
M2909_02265	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2909_02270	COG5294	Protein conserved in bacteria
M2909_02280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2909_02295	COG3906	Belongs to the UPF0473 family
M2909_02305	COG4472	Bacterial protein of unknown function (DUF965)
M2909_02310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2909_02315	COG0589	response to stress
M2909_02320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2909_02325	COG1363	Peptidase, m42
M2909_02335	COG1486	melibiose metabolic process
M2909_02350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2909_02355	COG0510	thiamine kinase activity
M2909_02365	COG1131	(ABC) transporter
M2909_02370	COG0537	adenosine 5'-monophosphoramidase activity
M2909_02380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2909_02385	COG3481	metal-dependent phosphohydrolase, HD sub domain
M2909_02390	COG3679	Belongs to the UPF0342 family
M2909_02395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2909_02400	COG0564	pseudouridine synthase activity
M2909_02410	COG1438	arginine binding
M2909_02415	COG0018	arginyl-trna synthetase
M2909_02420	COG4708	membrane
M2909_02430	COG1116	anion transmembrane transporter activity
M2909_02435	COG4521	taurine ABC transporter
M2909_02440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2909_02445	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2909_02450	COG2391	methyltransferase activity
M2909_02455	COG0583	DNA-binding transcription factor activity
M2909_02460	COG1597	lipid kinase activity
M2909_02465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M2909_02470	COG3480	Lon protease (S16) C-terminal proteolytic domain
M2909_02475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M2909_02480	COG0742	ribosomal rna small subunit methyltransferase
M2909_02485	COG4471	UPF0298 protein
M2909_02500	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M2909_02505	COG0772	Belongs to the SEDS family
M2909_02510	COG4838	Belongs to the UPF0358 family
M2909_02525	COG1674	ftsk spoiiie
M2909_02535	COG2946	Replication initiation factor
M2909_02565	COG0741	lytic transglycosylase activity
M2909_02565	COG0791	NLP P60 protein
M2909_02625	COG2116	formate transmembrane transporter activity
M2909_02630	COG1464	Belongs to the NlpA lipoprotein family
M2909_02635	COG2011	ABC-type metal ion transport system permease component
M2909_02645	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M2909_02650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M2909_02655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2909_02660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M2909_02660	COG1116	anion transmembrane transporter activity
M2909_02670	COG0352	thiamine-phosphate diphosphorylase activity
M2909_02675	COG0351	phosphomethylpyrimidine kinase
M2909_02685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M2909_02690	COG0544	peptidyl-prolyl cis-trans isomerase activity
M2909_02700	COG1714	RDD family
M2909_02710	COG4703	Protein of unknown function (DUF1797)
M2909_02720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2909_02725	COG3716	PTS system mannose fructose sorbose family IID component
M2909_02735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_02740	COG1105	Belongs to the carbohydrate kinase PfkB family
M2909_02745	COG3684	Belongs to the aldolase LacD family
M2909_02750	COG2222	sugar isomerase
M2909_02755	COG2188	Transcriptional regulator
M2909_02760	COG2084	Dehydrogenase
M2909_02770	COG0438	transferase activity, transferring glycosyl groups
M2909_02775	COG0438	transferase activity, transferring glycosyl groups
M2909_02780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2909_02785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2909_02795	COG0542	response to heat
M2909_02805	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M2909_02810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M2909_02815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M2909_02820	COG0584	glycerophosphoryl diester phosphodiesterase
M2909_02830	COG1278	Cold shock
M2909_02835	COG2003	Belongs to the UPF0758 family
M2909_02840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2909_02845	COG0285	dihydrofolate synthase activity
M2909_02850	COG0525	valine-tRNA ligase activity
M2909_02855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M2909_02860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2909_02870	COG1104	cysteine desulfurase activity
M2909_02875	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M2909_02880	COG0561	phosphatase activity
M2909_02885	COG1801	Protein of unknown function DUF72
M2909_02900	COG0166	Belongs to the GPI family
M2909_02905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2909_02910	COG2081	HI0933 family
M2909_02930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2909_02935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2909_02945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M2909_02950	COG1368	sulfuric ester hydrolase activity
M2909_02960	COG0765	amino acid transport
M2909_02965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2909_02975	COG1368	sulfuric ester hydrolase activity
M2909_02980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M2909_02985	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M2909_02995	COG0500	methyltransferase
M2909_03000	COG3142	Participates in the control of copper homeostasis
M2909_03005	COG2239	Acts as a magnesium transporter
M2909_03010	COG0564	pseudouridine synthase activity
M2909_03015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M2909_03020	COG2357	RelA SpoT domain protein
M2909_03025	COG4116	CYTH
M2909_03035	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M2909_03040	COG0640	Transcriptional regulator
M2909_03045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2909_03050	COG1136	(ABC) transporter
M2909_03050	COG0577	efflux transmembrane transporter activity
M2909_03055	COG1136	(ABC) transporter
M2909_03055	COG0577	efflux transmembrane transporter activity
M2909_03065	COG1278	Cold shock
M2909_03070	COG1879	ABC-type sugar transport system periplasmic component
M2909_03075	COG1172	Belongs to the binding-protein-dependent transport system permease family
M2909_03080	COG1129	ABC transporter
M2909_03090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2909_03095	COG1609	Transcriptional regulator
M2909_03110	COG1253	flavin adenine dinucleotide binding
M2909_03115	COG0628	permease
M2909_03135	COG3557	Belongs to the UPF0374 family
M2909_03155	COG3764	Sortase (surface protein transpeptidase)
M2909_03175	COG0392	lysyltransferase activity
M2909_03175	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2909_03180	COG1194	a g-specific adenine glycosylase
M2909_03185	COG2137	regulation of response to DNA damage stimulus
M2909_03215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M2909_03225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M2909_03230	COG1316	TRANSCRIPTIONal
M2909_03240	COG0686	Belongs to the AlaDH PNT family
M2909_03255	COG1442	glycosyl transferase family 8
M2909_03285	COG1086	Polysaccharide biosynthesis protein
M2909_03300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M2909_03310	COG4464	protein tyrosine phosphatase activity
M2909_03315	COG0489	protein tyrosine kinase activity
M2909_03320	COG3944	biosynthesis protein
M2909_03350	COG0463	Glycosyl transferase, family 2
M2909_03350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2909_03355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2909_03360	COG0463	Glycosyl transferase, family 2
M2909_03360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2909_03365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2909_03370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2909_03375	COG1682	transport, permease protein
M2909_03380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M2909_03385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2909_03390	COG1134	teichoic acid transport
M2909_03395	COG1316	TRANSCRIPTIONal
M2909_03400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2909_03405	COG1295	ribonuclease BN
M2909_03410	COG0024	Methionine aminopeptidase
M2909_03415	COG0716	FMN binding
M2909_03425	COG2309	aminopeptidase activity
M2909_03450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2909_03460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2909_03465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2909_03465	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2909_03475	COG0673	inositol 2-dehydrogenase activity
M2909_03485	COG1132	(ABC) transporter
M2909_03495	COG5503	Protein of unknown function (DUF1447)
M2909_03505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M2909_03510	COG1940	carbohydrate kinase activity
M2909_03515	COG0705	Rhomboid family
M2909_03515	COG0457	Tetratricopeptide repeat
M2909_03525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2909_03530	COG0768	penicillin binding
M2909_03535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M2909_03540	COG1185	polyribonucleotide nucleotidyltransferase activity
M2909_03545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M2909_03550	COG0242	peptide deformylase activity
M2909_03560	COG2207	Transcriptional regulator
M2909_03570	COG0737	Belongs to the 5'-nucleotidase family
M2909_03575	COG1737	Transcriptional regulator
M2909_03580	COG0114	fumarate hydratase activity
M2909_03585	COG0281	malic enzyme
M2909_03590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M2909_03595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_03595	COG1263	PTS System
M2909_03600	COG0656	L-ascorbic acid biosynthetic process
M2909_03605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M2909_03615	COG3842	ATPase activity
M2909_03625	COG4753	response regulator
M2909_03625	COG2207	Transcriptional regulator
M2909_03630	COG2972	Histidine kinase
M2909_03635	COG0459	protein refolding
M2909_03640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M2909_03645	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2909_03650	COG0488	(ABC) transporter
M2909_03655	COG1609	Transcriptional regulator
M2909_03665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M2909_03670	COG4109	DRTGG domain
M2909_03675	COG2814	Major facilitator Superfamily
M2909_03685	COG1132	(ABC) transporter
M2909_03690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2909_03695	COG0204	Acyl-transferase
M2909_03700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M2909_03705	COG2827	Endonuclease containing a URI domain
M2909_03730	COG1959	2 iron, 2 sulfur cluster binding
M2909_03735	COG1288	antiporter activity
M2909_03740	COG2376	Dihydroxyacetone kinase
M2909_03745	COG1461	Dihydroxyacetone kinase
M2909_03750	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M2909_03760	COG2376	Dihydroxyacetone kinase
M2909_03765	COG1309	transcriptional regulator
M2909_03775	COG0494	nUDIX hydrolase
M2909_03790	COG2390	Transcriptional regulator
M2909_03795	COG3634	alkyl hydroperoxide reductase activity
M2909_03800	COG0450	alkyl hydroperoxide reductase
M2909_03810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M2909_03815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M2909_03820	COG0183	Belongs to the thiolase family
M2909_03825	COG1136	(ABC) transporter
M2909_03830	COG0577	efflux transmembrane transporter activity
M2909_03850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2909_03995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M2909_04000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2909_04005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M2909_04010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2909_04015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M2909_04020	COG0037	tRNA processing
M2909_04025	COG1098	S1 RNA binding domain
M2909_04035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M2909_04040	COG2244	polysaccharide biosynthetic process
M2909_04045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M2909_04050	COG0193	aminoacyl-tRNA hydrolase activity
M2909_04060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M2909_04065	COG1780	Probably involved in ribonucleotide reductase function
M2909_04070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2909_04075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2909_04085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2909_04090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2909_04095	COG4684	Psort location CytoplasmicMembrane, score
M2909_04100	COG4862	establishment of competence for transformation
M2909_04105	COG1393	Belongs to the ArsC family
M2909_04110	COG0180	Tryptophanyl-tRNA synthetase
M2909_04115	COG0095	Lipoate-protein ligase
M2909_04120	COG1234	tRNA 3'-trailer cleavage
M2909_04125	COG1363	Peptidase, m42
M2909_04135	COG1328	CTP reductase activity
M2909_04140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M2909_04145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M2909_04150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M2909_04155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M2909_04160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M2909_04170	COG2249	NAD(P)H dehydrogenase (quinone) activity
M2909_04200	COG0572	uridine kinase
M2909_04205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M2909_04325	COG2369	cell adhesion
M2909_04415	COG1484	DNA-dependent DNA replication
M2909_04475	COG1459	type II secretion system
M2909_04480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M2909_04485	COG0217	transcriptional regulatory protein
M2909_04495	COG3688	RNA-binding protein containing a PIN domain
M2909_04505	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M2909_04510	COG0215	cysteine-tRNA ligase activity
M2909_04515	COG1045	serine acetyltransferase
M2909_04520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2909_04525	COG4956	integral membrane protein (PIN domain superfamily)
M2909_04535	COG0756	dUTP diphosphatase activity
M2909_04540	COG1937	Protein conserved in bacteria
M2909_04545	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2909_04555	COG1187	pseudouridine synthase activity
M2909_04560	COG2244	polysaccharide biosynthetic process
M2909_04565	COG1363	Peptidase, m42
M2909_04575	COG4493	Belongs to the UPF0637 family
M2909_04580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2909_04585	COG1605	Chorismate mutase
M2909_04585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M2909_04600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2909_04605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2909_04610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M2909_04615	COG0124	histidyl-tRNA synthetase
M2909_04620	COG4991	sh3 domain protein
M2909_04620	COG0860	N-Acetylmuramoyl-L-alanine amidase
M2909_04620	COG3103	Sh3 type 3 domain protein
M2909_04625	COG1490	D-aminoacyl-tRNA deacylase activity
M2909_04630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2909_04655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M2909_04660	COG2264	protein methyltransferase activity
M2909_04670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M2909_04685	COG0589	response to stress
M2909_04690	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2909_04695	COG0737	Belongs to the 5'-nucleotidase family
M2909_04700	COG3639	organic phosphonate transmembrane transporter activity
M2909_04720	COG3579	cysteine-type endopeptidase activity
M2909_04735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2909_04750	COG3859	Proton-coupled thiamine transporter YuaJ
M2909_04755	COG2076	Multidrug Resistance protein
M2909_04760	COG2076	Multidrug Resistance protein
M2909_04775	COG1482	cell wall glycoprotein biosynthetic process
M2909_04790	COG0395	ABC-type sugar transport system, permease component
M2909_04795	COG4209	transmembrane transport
M2909_04825	COG2723	6-phospho-beta-galactosidase activity
M2909_04830	COG0456	acetyltransferase
M2909_04845	COG3291	Pkd domain containing protein
M2909_04845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M2909_04860	COG0488	(ABC) transporter
M2909_04870	COG0477	Major facilitator Superfamily
M2909_04880	COG2003	Belongs to the UPF0758 family
M2909_04895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2909_04905	COG3973	AAA domain
M2909_04925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2909_04930	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M2909_05015	COG1401	restriction endodeoxyribonuclease activity
M2909_05035	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M2909_05050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M2909_05055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M2909_05060	COG0101	tRNA pseudouridine synthase activity
M2909_05070	COG1122	ATPase activity
M2909_05075	COG1122	ATPase activity
M2909_05080	COG0203	ribosomal protein L17
M2909_05085	COG0202	RNA polymerase activity
M2909_05090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M2909_05095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M2909_05100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M2909_05110	COG0563	adenylate kinase activity
M2909_05115	COG0201	protein transport
M2909_05120	COG0200	Binds to the 23S rRNA
M2909_05125	COG1841	ribosomal large subunit assembly
M2909_05130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M2909_05140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M2909_05145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M2909_05150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M2909_05155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M2909_05160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M2909_05165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M2909_05170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M2909_05175	COG0255	Belongs to the universal ribosomal protein uL29 family
M2909_05180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M2909_05185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M2909_05190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M2909_05200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M2909_05205	COG0089	rRNA binding
M2909_05210	COG0088	Forms part of the polypeptide exit tunnel
M2909_05215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M2909_05220	COG0051	transcription antitermination factor activity, RNA binding
M2909_05230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M2909_05235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2909_05240	COG0049	tRNA binding
M2909_05245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M2909_05250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M2909_05255	COG0813	purine-nucleoside phosphorylase activity
M2909_05260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M2909_05265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M2909_05270	COG1079	Belongs to the binding-protein-dependent transport system permease family
M2909_05275	COG4603	Belongs to the binding-protein-dependent transport system permease family
M2909_05280	COG3845	ABC transporter
M2909_05285	COG1744	ABC transporter substrate-binding protein PnrA-like
M2909_05290	COG0295	cytidine deaminase activity
M2909_05295	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M2909_05310	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2909_05315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2909_05335	COG4939	FMN-binding domain protein
M2909_05355	COG0488	(ABC) transporter
M2909_05365	COG0305	Participates in initiation and elongation during chromosome replication
M2909_05370	COG0359	binds to the 23S rRNA
M2909_05375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M2909_05385	COG0360	Binds together with S18 to 16S ribosomal RNA
M2909_05395	COG0187	DNA topoisomerase II activity
M2909_05400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M2909_05405	COG2501	S4 domain
M2909_05420	COG1028	Short-chain dehydrogenase reductase Sdr
M2909_05425	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M2909_05430	COG1414	Transcriptional regulator
M2909_05435	COG0800	Aldolase
M2909_05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2909_05445	COG5492	domain, Protein
M2909_05460	COG3716	PTS system mannose fructose sorbose family IID component
M2909_05465	COG3715	PTS system
M2909_05475	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M2909_05480	COG2188	Transcriptional regulator
M2909_05485	COG0592	DNA-directed DNA polymerase activity
M2909_05490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2909_05495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M2909_05505	COG0706	membrane insertase activity
M2909_05515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2909_05520	COG0445	tRNA wobble uridine modification
M2909_05535	COG0357	Ribosomal RNA small subunit methyltransferase G
M2909_05540	COG1192	Involved in chromosome partitioning
M2909_05545	COG1475	DNA binding
M2909_05550	COG4481	Protein conserved in bacteria
M2909_05555	COG0012	GTP binding
M2909_05565	COG0516	GMP reductase activity
M2909_05565	COG0517	IMP dehydrogenase activity
M2909_05620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M2909_05625	COG1686	Belongs to the peptidase S11 family
M2909_05640	COG0406	alpha-ribazole phosphatase activity
M2909_05700	COG4463	regulation of RNA biosynthetic process
M2909_05705	COG0542	response to heat
M2909_05715	COG0826	peptidase U32
M2909_05725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2909_05730	COG1271	oxidase subunit
M2909_05735	COG1294	oxidase, subunit
M2909_05740	COG4988	ABC transporter
M2909_05745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2909_05755	COG0142	geranyltranstransferase activity
M2909_05770	COG0561	phosphatase activity
M2909_05775	COG0280	phosphate acetyltransferase
M2909_05780	COG0802	atpase or kinase
M2909_05785	COG0737	Belongs to the 5'-nucleotidase family
M2909_05800	COG0708	Exodeoxyribonuclease III
M2909_05805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M2909_05810	COG0604	alcohol dehydrogenase
M2909_05820	COG3842	ATPase activity
M2909_05825	COG1176	ABC-type spermidine putrescine transport system, permease component I
M2909_05830	COG1177	transmembrane transport
M2909_05835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M2909_05840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M2909_05845	COG1263	PTS System
M2909_05845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_05845	COG2190	(PTS) system
M2909_05855	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2909_05860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2909_05865	COG1121	(ABC) transporter
M2909_05870	COG1121	(ABC) transporter
M2909_05875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2909_05880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2909_05890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M2909_05895	COG1970	mechanosensitive ion channel activity
M2909_05900	COG0612	Peptidase, M16
M2909_05905	COG0612	Peptidase, M16
M2909_05915	COG1426	Protein conserved in bacteria
M2909_05920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M2909_05925	COG1058	Belongs to the CinA family
M2909_05925	COG1546	Belongs to the CinA family
M2909_05930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M2909_05935	COG1418	mRNA catabolic process
M2909_05955	COG1278	Cold shock
M2909_05970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M2909_05975	COG1263	PTS System
M2909_05975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_05980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2909_05985	COG1737	Transcriptional regulator
M2909_05990	COG3973	AAA domain
M2909_05995	COG0745	RESPONSE REGULATOR receiver
M2909_06000	COG5002	protein histidine kinase activity
M2909_06015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M2909_06020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2909_06045	COG0626	cystathionine gamma-synthase activity
M2909_06050	COG2188	Transcriptional regulator
M2909_06060	COG3457	Alanine racemase
M2909_06065	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M2909_06075	COG0625	glutathione transferase activity
M2909_06085	COG0590	tRNA wobble adenosine to inosine editing
M2909_06095	COG1263	PTS System
M2909_06095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_06095	COG2190	(PTS) system
M2909_06100	COG3711	transcriptional antiterminator
M2909_06105	COG2723	6-phospho-beta-galactosidase activity
M2909_06115	COG1285	pathogenesis
M2909_06120	COG2814	Major facilitator Superfamily
M2909_06125	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2909_06125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2909_06130	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2909_06130	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_06140	COG3715	PTS system
M2909_06145	COG3716	PTS system mannose fructose sorbose family IID component
M2909_06180	COG4720	Psort location CytoplasmicMembrane, score
M2909_06185	COG1122	ATPase activity
M2909_06205	COG0402	S-adenosylhomocysteine deaminase activity
M2909_06215	COG0737	Belongs to the 5'-nucleotidase family
M2909_06220	COG2246	polysaccharide biosynthetic process
M2909_06225	COG0463	Glycosyl transferase, family 2
M2909_06235	COG4619	ABC transporter
M2909_06240	COG0390	transport system, permease component
M2909_06250	COG0583	DNA-binding transcription factor activity
M2909_06260	COG3711	transcriptional antiterminator
M2909_06260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2909_06270	COG3730	PTS system glucitol sorbitol-specific
M2909_06275	COG3732	PTS system glucitol sorbitol-specific
M2909_06295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2909_06305	COG2910	NAD(P)H-binding
M2909_06310	COG1733	regulation of RNA biosynthetic process
M2909_06315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2909_06320	COG2233	PERMEase
M2909_06325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_06325	COG1263	PTS System
M2909_06330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_06330	COG1263	PTS System
M2909_06330	COG2190	(PTS) system
M2909_06335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2909_06340	COG1609	Transcriptional regulator
M2909_06350	COG1621	beta-fructofuranosidase activity
M2909_06380	COG0156	8-amino-7-oxononanoate synthase activity
M2909_06385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2909_06395	COG1979	alcohol dehydrogenase
M2909_06400	COG0383	alpha-mannosidase activity
M2909_06430	COG1054	Belongs to the UPF0176 family
M2909_06435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2909_06440	COG2094	Belongs to the DNA glycosylase MPG family
M2909_06450	COG1378	Sugar-specific transcriptional regulator TrmB
M2909_06465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2909_06465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2909_06465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2909_06470	COG1105	Belongs to the carbohydrate kinase PfkB family
M2909_06475	COG1349	DNA-binding transcription factor activity
M2909_06480	COG1692	metallophosphoesterase
M2909_06490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M2909_06500	COG0424	maF-like protein
M2909_06520	COG1418	mRNA catabolic process
M2909_06535	COG1346	cytolysis
M2909_06540	COG0517	IMP dehydrogenase activity
M2909_06545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2909_06550	COG1597	lipid kinase activity
M2909_06560	COG0561	phosphatase activity
M2909_06565	COG0745	RESPONSE REGULATOR receiver
M2909_06570	COG3850	Histidine kinase
M2909_06570	COG5002	protein histidine kinase activity
M2909_06575	COG4476	Belongs to the UPF0223 family
M2909_06580	COG0483	inositol monophosphate 1-phosphatase activity
M2909_06585	COG1217	gtp-binding protein TYPA
M2909_06610	COG0191	fructose-bisphosphate aldolase activity
M2909_06625	COG2706	6-phosphogluconolactonase activity
M2909_06635	COG0628	permease
M2909_06645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M2909_06665	COG2824	Alkylphosphonate utilization operon protein PhnA
M2909_06670	COG2738	Putative neutral zinc metallopeptidase
M2909_06680	COG2508	Transcriptional regulator
M2909_06685	COG0590	tRNA wobble adenosine to inosine editing
M2909_06710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M2909_06715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M2909_06720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M2909_06725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M2909_06730	COG3870	Protein conserved in bacteria
M2909_06735	COG0470	DNA polymerase III
M2909_06740	COG1774	PSP1 C-terminal conserved region
M2909_06745	COG4467	Involved in initiation control of chromosome replication
M2909_06785	COG1132	(ABC) transporter
M2909_06790	COG1132	(ABC) transporter
M2909_06795	COG4475	Protein of unknown function (DUF436)
M2909_06800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M2909_06810	COG0765	amino acid transport
M2909_06820	COG4717	serine-type aminopeptidase activity
M2909_06830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M2909_06835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M2909_06845	COG1555	photosystem II stabilization
M2909_06845	COG1596	polysaccharide export
M2909_06850	COG2131	deaminase
M2909_06855	COG0658	competence protein
M2909_06855	COG2333	competence protein COMEC
M2909_06860	COG1466	dna polymerase III delta subunit
M2909_06865	COG0268	Binds directly to 16S ribosomal RNA
M2909_06870	COG0306	phosphate transporter
M2909_06875	COG1392	Phosphate transport regulator
M2909_06880	COG2217	Heavy metal translocating P-type atpase
M2909_06885	COG1968	undecaprenyl-diphosphatase activity
M2909_06890	COG2207	Transcriptional regulator
M2909_06895	COG0673	inositol 2-dehydrogenase activity
M2909_06905	COG1082	Xylose isomerase domain protein TIM barrel
M2909_06910	COG0673	inositol 2-dehydrogenase activity
M2909_06915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M2909_06945	COG1732	Glycine betaine
M2909_06950	COG1174	glycine betaine transport
M2909_06955	COG0436	Aminotransferase
M2909_06975	COG0110	maltose O-acetyltransferase activity
M2909_06980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2909_06990	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M2909_07000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2909_07000	COG0574	Belongs to the PEP-utilizing enzyme family
M2909_07005	COG0584	glycerophosphoryl diester phosphodiesterase
M2909_07010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2909_07010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2909_07015	COG0084	hydrolase, TatD family'
M2909_07020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M2909_07025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2909_07030	COG3842	ATPase activity
M2909_07035	COG1803	Methylglyoxal synthase
M2909_07040	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2909_07045	COG0827	DNA restriction-modification system
M2909_07050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2909_07055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2909_07060	COG4605	iron ion homeostasis
M2909_07065	COG4604	ABC transporter, ATP-binding protein
M2909_07070	COG4607	ABC-type enterochelin transport system periplasmic component
M2909_07090	COG1942	4-Oxalocrotonate Tautomerase
M2909_07095	COG1349	DNA-binding transcription factor activity
M2909_07100	COG1012	belongs to the aldehyde dehydrogenase family
M2909_07105	COG3718	enzyme involved in inositol metabolism
M2909_07110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2909_07115	COG3962	Belongs to the TPP enzyme family
M2909_07120	COG0673	inositol 2-dehydrogenase activity
M2909_07125	COG1082	Xylose isomerase domain protein TIM barrel
M2909_07130	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2909_07135	COG0673	inositol 2-dehydrogenase activity
M2909_07145	COG0632	four-way junction helicase activity
M2909_07150	COG2255	four-way junction helicase activity
M2909_07155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M2909_07160	COG0343	queuine tRNA-ribosyltransferase activity
M2909_07165	COG1862	Preprotein translocase
M2909_07175	COG1012	belongs to the aldehyde dehydrogenase family
M2909_07175	COG1454	alcohol dehydrogenase
M2909_07200	COG1164	Oligoendopeptidase f
M2909_07210	COG4466	Protein conserved in bacteria
M2909_07215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2909_07220	COG2188	Transcriptional regulator
M2909_07225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2909_07230	COG1446	asparaginase
M2909_07245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2909_07250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2909_07265	COG1959	2 iron, 2 sulfur cluster binding
M2909_07270	COG2188	Transcriptional regulator
M2909_07275	COG0366	Alpha amylase catalytic
M2909_07280	COG1263	PTS System
M2909_07280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_07305	COG0789	Transcriptional regulator
M2909_07315	COG2188	Transcriptional regulator
M2909_07320	COG2723	6-phospho-beta-galactosidase activity
M2909_07325	COG0741	lytic transglycosylase activity
M2909_07325	COG1196	nuclear chromosome segregation
M2909_07325	COG0739	heme binding
M2909_07335	COG0726	polysaccharide deacetylase
M2909_07355	COG3284	Transcriptional regulator
M2909_07360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2909_07365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2909_07370	COG0022	dehydrogenase e1 component
M2909_07375	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2909_07380	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M2909_07385	COG0531	amino acid
M2909_07445	COG0582	viral genome integration into host DNA
M2909_07455	COG0519	Catalyzes the synthesis of GMP from XMP
M2909_07455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2909_07460	COG1072	(Pantothenic acid kinase))
M2909_07465	COG1607	acyl-coa hydrolase
M2909_07475	COG2813	Specifically methylates the guanine in position
M2909_07480	COG0052	Belongs to the universal ribosomal protein uS2 family
M2909_07485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M2909_07490	COG0528	UMP kinase activity
M2909_07495	COG0233	cytoplasmic translational termination
M2909_07500	COG0038	chloride channel
M2909_07505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M2909_07510	COG4589	Belongs to the CDS family
M2909_07515	COG0750	zinc metalloprotease
M2909_07520	COG0442	prolyl-tRNA aminoacylation
M2909_07525	COG2176	DNA-directed DNA polymerase activity
M2909_07530	COG0735	belongs to the Fur family
M2909_07610	COG0322	excinuclease ABC activity
M2909_07620	COG4152	abc transporter atp-binding protein
M2909_07625	COG1668	transmembrane transport
M2909_07630	COG0210	DNA helicase
M2909_07635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M2909_07640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2909_07645	COG0154	amidase activity
M2909_07650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2909_07655	COG1597	lipid kinase activity
M2909_07660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2909_07675	COG2226	methyltransferase
M2909_07685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2909_07705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M2909_07720	COG2608	mercury ion transmembrane transporter activity
M2909_07725	COG1114	Component of the transport system for branched-chain amino acids
M2909_07740	COG1132	(ABC) transporter
M2909_07750	COG1686	Belongs to the peptidase S11 family
M2909_07755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2909_07760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M2909_07765	COG0254	rRNA binding
M2909_07770	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2909_07770	COG1388	LysM domain
M2909_07775	COG2017	converts alpha-aldose to the beta-anomer
M2909_07780	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M2909_07785	COG4106	trans-aconitate 2-methyltransferase activity
M2909_07790	COG0589	response to stress
M2909_07810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M2909_07820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M2909_07825	COG0006	proline dipeptidase activity
M2909_07830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M2909_07835	COG1302	Protein conserved in bacteria
M2909_07840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2909_07845	COG1570	exodeoxyribonuclease VII activity
M2909_07850	COG1722	exodeoxyribonuclease VII activity
M2909_07855	COG0142	geranyltranstransferase activity
M2909_07860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M2909_07865	COG1438	arginine binding
M2909_07870	COG0497	DNA recombination
M2909_07885	COG2001	Belongs to the MraZ family
M2909_07890	COG0275	rRNA processing
M2909_07900	COG0768	penicillin binding
M2909_07905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2909_07910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M2909_07915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M2909_07925	COG0849	cell division
M2909_07935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2909_07940	COG1799	cell septum assembly
M2909_07950	COG2302	S4 RNA-binding domain
M2909_07955	COG3599	regulation of cell shape
M2909_07960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M2909_07990	COG1203	CRISPR-associated helicase, Cas3
M2909_08000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2909_08010	COG0250	Participates in transcription elongation, termination and antitermination
M2909_08015	COG3123	guanosine phosphorylase activity
M2909_08020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2909_08040	COG1396	sequence-specific DNA binding
M2909_08045	COG1760	l-serine dehydratase
M2909_08050	COG1760	l-serine dehydratase
M2909_08055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M2909_08060	COG0081	regulation of translation
M2909_08065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M2909_08070	COG0222	ribosome binding
M2909_08080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M2909_08085	COG0477	Major facilitator Superfamily
M2909_08090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M2909_08095	COG1242	4 iron, 4 sulfur cluster binding
M2909_08100	COG0671	phosphoesterase, PA-phosphatase related
M2909_08115	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2909_08115	COG1388	LysM domain
M2909_08120	COG0495	leucyl-tRNA aminoacylation
M2909_08125	COG1671	Belongs to the UPF0178 family
M2909_08130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M2909_08135	COG3764	Sortase (surface protein transpeptidase)
M2909_08145	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2909_08150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2909_08160	COG0736	holo-[acyl-carrier-protein] synthase activity
M2909_08175	COG4443	Transcriptional Coactivator p15 (PC4)
M2909_08180	COG1561	YicC-like family, N-terminal region
M2909_08185	COG0194	GDP metabolic process
M2909_08195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M2909_08200	COG0242	peptide deformylase activity
M2909_08205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M2909_08210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2909_08210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M2909_08215	COG0631	protein serine/threonine phosphatase activity
M2909_08220	COG2815	serine threonine protein kinase
M2909_08220	COG0515	serine threonine protein kinase
M2909_08225	COG0785	Cytochrome C biogenesis protein
M2909_08235	COG1162	GTPase activity
M2909_08240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M2909_08245	COG1564	THIamine pyrophosphokinase
M2909_08250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M2909_08265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M2909_08270	COG0416	fatty acid biosynthetic process
M2909_08275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2909_08285	COG4608	Belongs to the ABC transporter superfamily
M2909_08290	COG0601	transmembrane transport
M2909_08310	COG0571	ribonuclease III activity
M2909_08315	COG1196	nuclear chromosome segregation
M2909_08320	COG0561	phosphatase activity
M2909_08325	COG0552	protein localization to endoplasmic reticulum
M2909_08330	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2909_08330	COG2918	glutathione biosynthetic process
M2909_08335	COG3853	Toxic anion resistance protein (TelA)
M2909_08355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2909_08360	COG1335	isochorismatase
M2909_08365	COG3594	Acyltransferase
M2909_08370	COG1104	cysteine desulfurase activity
M2909_08380	COG0482	sulfurtransferase activity
M2909_08385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M2909_08385	COG2207	Transcriptional regulator
M2909_08390	COG1132	(ABC) transporter
M2909_08395	COG1132	(ABC) transporter
M2909_08410	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M2909_08420	COG0719	Fe-S assembly protein
M2909_08425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M2909_08430	COG0822	iron-sulfur transferase activity
M2909_08440	COG1609	Transcriptional regulator
M2909_08475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2909_08480	COG0800	Aldolase
M2909_08490	COG0601	transmembrane transport
M2909_08495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2909_08510	COG1691	(AIR) carboxylase
M2909_08520	COG1606	tRNA processing
M2909_08525	COG1609	Transcriptional regulator
M2909_08535	COG1175	transmembrane transport
M2909_08540	COG0395	ABC-type sugar transport system, permease component
M2909_08545	COG0191	fructose-bisphosphate aldolase activity
M2909_08550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M2909_08560	COG1609	Transcriptional regulator
M2909_08565	COG0205	6-phosphofructokinase activity
M2909_08570	COG0149	triose-phosphate isomerase activity
M2909_08590	COG0488	(ABC) transporter
M2909_08610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2909_08630	COG4753	response regulator
M2909_08630	COG2207	Transcriptional regulator
M2909_08635	COG2972	Histidine kinase
M2909_08640	COG3976	FMN-binding domain protein
M2909_08640	COG1053	succinate dehydrogenase
M2909_08645	COG0346	lactoylglutathione lyase activity
M2909_08670	COG0450	alkyl hydroperoxide reductase
M2909_08675	COG3104	oligopeptide transport
M2909_08690	COG0431	NADPH-dependent FMN reductase
M2909_08690	COG1053	succinate dehydrogenase
M2909_08690	COG3976	FMN-binding domain protein
M2909_08715	COG3711	transcriptional antiterminator
M2909_08720	COG1263	PTS System
M2909_08720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2909_08720	COG2190	(PTS) system
M2909_08725	COG2723	6-phospho-beta-galactosidase activity
M2909_08750	COG0395	ABC-type sugar transport system, permease component
M2909_08760	COG4209	transmembrane transport
M2909_08765	COG2197	response regulator
M2909_08770	COG2972	Histidine kinase
M2909_08800	COG1940	carbohydrate kinase activity
M2909_08810	COG1473	amidohydrolase
M2909_08845	COG0420	3'-5' exonuclease activity
M2909_08850	COG0419	ATPase involved in DNA repair
M2909_08860	COG1846	Transcriptional regulator
M2909_08865	COG0346	lactoylglutathione lyase activity
M2909_08875	COG0431	NADPH-dependent FMN reductase
M2909_08885	COG0415	Belongs to the DNA photolyase family
M2909_08900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M2909_08910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M2909_08915	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M2909_08920	COG1534	Rna-binding protein
M2909_08925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M2909_08930	COG1713	HD superfamily hydrolase involved in NAD metabolism
M2909_08935	COG0799	negative regulation of ribosome biogenesis
M2909_08940	COG2226	methyltransferase
M2909_08950	COG0516	GMP reductase activity
M2909_08960	COG0351	phosphomethylpyrimidine kinase
M2909_08965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2909_08975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M2909_08980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2909_08990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2909_08995	COG1028	Short-chain dehydrogenase reductase Sdr
M2909_09000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M2909_09010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M2909_09015	COG0439	Biotin carboxylase
M2909_09020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M2909_09025	COG0825	malonyl-CoA metabolic process
M2909_09030	COG0583	DNA-binding transcription factor activity
M2909_09055	COG0280	phosphate acetyltransferase
M2909_09065	COG1126	abc transporter atp-binding protein
M2909_09070	COG0765	amino acid transport
M2909_09075	COG2966	Psort location CytoplasmicMembrane, score
M2909_09095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2909_09100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M2909_09110	COG0514	ATP-dependent DNA helicase (RecQ)
M2909_09115	COG2217	Heavy metal translocating P-type atpase
M2909_09120	COG1073	alpha beta
M2909_09125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2909_09135	COG1464	Belongs to the NlpA lipoprotein family
M2909_09140	COG1473	amidohydrolase
M2909_09150	COG0513	Belongs to the DEAD box helicase family
M2909_09155	COG3275	phosphorelay sensor kinase activity
M2909_09160	COG3279	Response regulator of the LytR AlgR family
M2909_09165	COG1966	Carbon starvation protein
M2909_09175	COG1269	ATP hydrolysis coupled proton transport
M2909_09180	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2909_09190	COG1527	subunit (C
M2909_09195	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
M2909_09200	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M2909_09205	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
M2909_09220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M2909_09230	COG0363	glucosamine-6-phosphate deaminase activity
M2909_09235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2909_09240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M2909_09245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M2909_09250	COG1609	Transcriptional regulator
M2909_09255	COG1214	PFAM Peptidase M22, glycoprotease
M2909_09265	COG0456	acetyltransferase
M2909_09270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M2909_09280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M2909_09295	COG0588	phosphoglycerate mutase activity
M2909_09300	COG0745	RESPONSE REGULATOR receiver
M2909_09305	COG2205	protein histidine kinase activity
M2909_09310	COG0765	amino acid transport
M2909_09315	COG1126	abc transporter atp-binding protein
M2909_09320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2909_09325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M2909_09330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M2909_09340	COG4585	Histidine kinase
M2909_09345	COG2197	response regulator
M2909_09350	COG0569	domain protein
M2909_09370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2909_09375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M2909_09380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2909_09390	COG1129	ABC transporter
M2909_09405	COG1428	Deoxynucleoside kinase
M2909_09410	COG1486	melibiose metabolic process
M2909_09420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2909_09425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2909_09425	COG0392	lysyltransferase activity
M2909_09440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2909_09450	COG3158	transport of potassium into the cell
M2909_09460	COG2814	Major facilitator Superfamily
M2909_09465	COG1252	NADH dehydrogenase
M2909_09475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2909_09480	COG3442	glutamine amidotransferase
M2909_09485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2909_09500	COG2746	aminoglycoside 3-N-acetyltransferase activity
M2909_09510	COG1757	Na H antiporter
M2909_09515	COG1609	Transcriptional regulator
M2909_09525	COG0556	nucleotide-excision repair
M2909_09530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M2909_09535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M2909_09540	COG1660	Displays ATPase and GTPase activities
M2909_09545	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M2909_09550	COG1481	regulation of sporulation
M2909_09555	COG0740	serine-type endopeptidase activity
M2909_09565	COG0335	large ribosomal subunit rRNA binding
M2909_09570	COG2514	catechol 2,3-dioxygenase activity
M2909_09575	COG1268	BioY protein
M2909_09580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2909_09585	COG1073	alpha beta
M2909_09590	COG2151	metal-sulfur cluster biosynthetic enzyme
M2909_09620	COG1073	alpha beta
M2909_09625	COG0280	phosphate acetyltransferase
M2909_09630	COG3426	butyrate kinase activity
M2909_09635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2909_09640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2909_09645	COG0022	dehydrogenase e1 component
M2909_09650	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2909_09660	COG0583	DNA-binding transcription factor activity
M2909_09665	COG1447	Phosphotransferase system cellobiose-specific component IIA
M2909_09670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2909_09670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2909_09685	COG1349	DNA-binding transcription factor activity
M2909_09700	COG3684	Belongs to the aldolase LacD family
M2909_09715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2909_09720	COG1882	Formate acetyltransferase
M2909_09725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M2909_09730	COG1227	inorganic diphosphatase activity
M2909_09735	COG1187	pseudouridine synthase activity
M2909_09750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M2909_09750	COG1199	ATP-dependent helicase activity
M2909_09760	COG0436	Aminotransferase
M2909_09775	COG2608	mercury ion transmembrane transporter activity
M2909_09780	COG2217	Heavy metal translocating P-type atpase
M2909_09790	COG2252	PERMEase
M2909_09795	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M2909_09805	COG2996	Protein conserved in bacteria
M2909_09815	COG0735	belongs to the Fur family
M2909_09820	COG4974	Belongs to the 'phage' integrase family
M2909_09825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M2909_09830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M2909_09835	COG1187	pseudouridine synthase activity
M2909_09840	COG0745	RESPONSE REGULATOR receiver
M2909_09845	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2909_09860	COG0514	ATP-dependent DNA helicase (RecQ)
M2909_09870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M2909_09875	COG0539	negative regulation of cytoplasmic translation
M2909_09880	COG1160	GTP binding
M2909_09895	COG5582	Belongs to the UPF0302 family
M2909_09910	COG0126	phosphoglycerate kinase activity
M2909_09915	COG0149	triose-phosphate isomerase activity
M2909_09955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2909_10005	COG0456	acetyltransferase
M2909_10020	COG0456	acetyltransferase
M2909_10040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2909_10050	COG0551	DNA topoisomerase type I activity
M2909_10050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2909_10075	COG1192	Involved in chromosome partitioning