locus-tag	class	description
K5X77_00070	COG0741	lytic transglycosylase activity
K5X77_00070	COG0791	NLP P60 protein
K5X77_00080	COG3711	transcriptional antiterminator
K5X77_00085	COG1263	PTS System
K5X77_00085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_00085	COG2190	(PTS) system
K5X77_00090	COG2723	6-phospho-beta-galactosidase activity
K5X77_00095	COG0488	(ABC) transporter
K5X77_00115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5X77_00145	COG4753	response regulator
K5X77_00145	COG2207	Transcriptional regulator
K5X77_00150	COG2972	Histidine kinase
K5X77_00155	COG3976	FMN-binding domain protein
K5X77_00155	COG1053	succinate dehydrogenase
K5X77_00160	COG0346	lactoylglutathione lyase activity
K5X77_00180	COG0450	alkyl hydroperoxide reductase
K5X77_00185	COG3104	oligopeptide transport
K5X77_00200	COG3976	FMN-binding domain protein
K5X77_00200	COG1053	succinate dehydrogenase
K5X77_00200	COG0431	NADPH-dependent FMN reductase
K5X77_00205	COG3976	FMN-binding domain protein
K5X77_00205	COG1053	succinate dehydrogenase
K5X77_00205	COG0431	NADPH-dependent FMN reductase
K5X77_00225	COG3711	transcriptional antiterminator
K5X77_00230	COG1263	PTS System
K5X77_00230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_00230	COG2190	(PTS) system
K5X77_00235	COG2723	6-phospho-beta-galactosidase activity
K5X77_00260	COG0395	ABC-type sugar transport system, permease component
K5X77_00270	COG4209	transmembrane transport
K5X77_00275	COG2197	response regulator
K5X77_00280	COG2972	Histidine kinase
K5X77_00310	COG1940	carbohydrate kinase activity
K5X77_00320	COG1473	amidohydrolase
K5X77_00335	COG4974	Belongs to the 'phage' integrase family
K5X77_00375	COG0420	3'-5' exonuclease activity
K5X77_00380	COG0419	ATPase involved in DNA repair
K5X77_00390	COG1846	Transcriptional regulator
K5X77_00395	COG0346	lactoylglutathione lyase activity
K5X77_00405	COG0431	NADPH-dependent FMN reductase
K5X77_00415	COG0415	Belongs to the DNA photolyase family
K5X77_00430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5X77_00440	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K5X77_00445	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5X77_00450	COG1534	Rna-binding protein
K5X77_00455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5X77_00460	COG1713	HD superfamily hydrolase involved in NAD metabolism
K5X77_00465	COG0799	negative regulation of ribosome biogenesis
K5X77_00470	COG2226	methyltransferase
K5X77_00480	COG0516	GMP reductase activity
K5X77_00490	COG0351	phosphomethylpyrimidine kinase
K5X77_00495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5X77_00505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5X77_00510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5X77_00520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5X77_00525	COG1028	Short-chain dehydrogenase reductase Sdr
K5X77_00530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X77_00540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5X77_00545	COG0439	Biotin carboxylase
K5X77_00550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5X77_00555	COG0825	malonyl-CoA metabolic process
K5X77_00560	COG0583	DNA-binding transcription factor activity
K5X77_00585	COG0280	phosphate acetyltransferase
K5X77_00595	COG1126	abc transporter atp-binding protein
K5X77_00600	COG0765	amino acid transport
K5X77_00605	COG2966	Psort location CytoplasmicMembrane, score
K5X77_00625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X77_00630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K5X77_00640	COG0514	ATP-dependent DNA helicase (RecQ)
K5X77_00645	COG2217	Heavy metal translocating P-type atpase
K5X77_00650	COG1073	alpha beta
K5X77_00655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5X77_00660	COG2011	ABC-type metal ion transport system permease component
K5X77_00665	COG1464	Belongs to the NlpA lipoprotein family
K5X77_00670	COG1473	amidohydrolase
K5X77_00680	COG0513	Belongs to the DEAD box helicase family
K5X77_00685	COG3275	phosphorelay sensor kinase activity
K5X77_00690	COG3279	Response regulator of the LytR AlgR family
K5X77_00695	COG1966	Carbon starvation protein
K5X77_00705	COG1269	ATP hydrolysis coupled proton transport
K5X77_00710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5X77_00720	COG1527	subunit (C
K5X77_00725	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
K5X77_00730	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5X77_00735	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K5X77_00765	COG0363	glucosamine-6-phosphate deaminase activity
K5X77_00770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5X77_00775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5X77_00780	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5X77_00785	COG1609	Transcriptional regulator
K5X77_00795	COG1214	PFAM Peptidase M22, glycoprotease
K5X77_00805	COG0456	acetyltransferase
K5X77_00810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5X77_00820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5X77_00830	COG0588	phosphoglycerate mutase activity
K5X77_00835	COG0745	RESPONSE REGULATOR receiver
K5X77_00840	COG2205	protein histidine kinase activity
K5X77_00845	COG0765	amino acid transport
K5X77_00850	COG1126	abc transporter atp-binding protein
K5X77_00855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5X77_00860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5X77_00865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5X77_00875	COG4585	Histidine kinase
K5X77_00880	COG2197	response regulator
K5X77_00885	COG0569	domain protein
K5X77_00905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5X77_00910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K5X77_00925	COG1129	ABC transporter
K5X77_00940	COG1428	Deoxynucleoside kinase
K5X77_00950	COG1486	melibiose metabolic process
K5X77_00960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5X77_00965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5X77_00970	COG0392	lysyltransferase activity
K5X77_00970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K5X77_00985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5X77_00995	COG3158	transport of potassium into the cell
K5X77_01005	COG2814	Major facilitator Superfamily
K5X77_01010	COG1252	NADH dehydrogenase
K5X77_01020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5X77_01025	COG3442	glutamine amidotransferase
K5X77_01030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5X77_01055	COG1757	Na H antiporter
K5X77_01060	COG1609	Transcriptional regulator
K5X77_01070	COG0556	nucleotide-excision repair
K5X77_01075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5X77_01080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5X77_01085	COG1660	Displays ATPase and GTPase activities
K5X77_01090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K5X77_01095	COG1481	regulation of sporulation
K5X77_01100	COG0740	serine-type endopeptidase activity
K5X77_01110	COG0335	large ribosomal subunit rRNA binding
K5X77_01115	COG2514	catechol 2,3-dioxygenase activity
K5X77_01120	COG1268	BioY protein
K5X77_01125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5X77_01130	COG1073	alpha beta
K5X77_01135	COG2151	metal-sulfur cluster biosynthetic enzyme
K5X77_01160	COG1073	alpha beta
K5X77_01165	COG0280	phosphate acetyltransferase
K5X77_01170	COG3426	butyrate kinase activity
K5X77_01175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5X77_01180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5X77_01185	COG0022	dehydrogenase e1 component
K5X77_01190	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X77_01200	COG0583	DNA-binding transcription factor activity
K5X77_01210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5X77_01215	COG1882	Formate acetyltransferase
K5X77_01220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5X77_01225	COG1227	inorganic diphosphatase activity
K5X77_01230	COG1187	pseudouridine synthase activity
K5X77_01245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5X77_01245	COG1199	ATP-dependent helicase activity
K5X77_01255	COG0436	Aminotransferase
K5X77_01270	COG2608	mercury ion transmembrane transporter activity
K5X77_01275	COG2217	Heavy metal translocating P-type atpase
K5X77_01290	COG2252	PERMEase
K5X77_01295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K5X77_01305	COG2996	Protein conserved in bacteria
K5X77_01315	COG0735	belongs to the Fur family
K5X77_01320	COG4974	Belongs to the 'phage' integrase family
K5X77_01325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5X77_01330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5X77_01335	COG1187	pseudouridine synthase activity
K5X77_01340	COG0745	RESPONSE REGULATOR receiver
K5X77_01345	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5X77_01360	COG0514	ATP-dependent DNA helicase (RecQ)
K5X77_01370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5X77_01375	COG0539	negative regulation of cytoplasmic translation
K5X77_01380	COG1160	GTP binding
K5X77_01395	COG5582	Belongs to the UPF0302 family
K5X77_01410	COG0126	phosphoglycerate kinase activity
K5X77_01415	COG0149	triose-phosphate isomerase activity
K5X77_01485	COG3448	diguanylate cyclase activity
K5X77_01485	COG4175	Glycine betaine
K5X77_01495	COG0039	L-malate dehydrogenase activity
K5X77_01510	COG1304	FMN binding
K5X77_01525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5X77_01545	COG3425	synthase
K5X77_01550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5X77_01560	COG3290	protein histidine kinase activity
K5X77_01560	COG3829	transcription factor binding
K5X77_01565	COG1454	alcohol dehydrogenase
K5X77_01570	COG1012	belongs to the aldehyde dehydrogenase family
K5X77_01575	COG4869	propanediol catabolic process
K5X77_01580	COG1012	belongs to the aldehyde dehydrogenase family
K5X77_01585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5X77_01595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5X77_01600	COG1234	tRNA 3'-trailer cleavage
K5X77_01605	COG0300	oxidoreductase activity
K5X77_01620	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5X77_01620	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5X77_01625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K5X77_01625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5X77_01630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5X77_01645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5X77_01655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5X77_01660	COG3331	DNA recombination
K5X77_01665	COG4474	Belongs to the UPF0398 family
K5X77_01680	COG0116	Belongs to the methyltransferase superfamily
K5X77_01685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5X77_01695	COG0328	RNA-DNA hybrid ribonuclease activity
K5X77_01705	COG1278	Cold shock
K5X77_01720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5X77_01725	COG0564	pseudouridine synthase activity
K5X77_01740	COG0540	Belongs to the ATCase OTCase family
K5X77_01745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5X77_01755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5X77_01760	COG0543	2 iron, 2 sulfur cluster binding
K5X77_01770	COG0284	orotidine-5'-phosphate decarboxylase activity
K5X77_01785	COG0475	glutathione-regulated potassium exporter activity
K5X77_01785	COG0569	domain protein
K5X77_01790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5X77_01795	COG0745	RESPONSE REGULATOR receiver
K5X77_01800	COG5002	protein histidine kinase activity
K5X77_01805	COG0038	chloride channel
K5X77_01815	COG1473	amidohydrolase
K5X77_01835	COG3711	transcriptional antiterminator
K5X77_01840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5X77_01850	COG0765	amino acid transport
K5X77_01855	COG0765	amino acid transport
K5X77_01860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5X77_01880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5X77_01880	COG2755	lipolytic protein G-D-S-L family
K5X77_01885	COG0628	permease
K5X77_01890	COG4479	Belongs to the UPF0346 family
K5X77_01895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5X77_01900	COG4698	Protein conserved in bacteria
K5X77_01905	COG2755	lipolytic protein G-D-S-L family
K5X77_01910	COG1307	EDD domain protein, DegV family
K5X77_01915	COG1272	protein, Hemolysin III
K5X77_01930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5X77_01935	COG0367	asparagine synthase
K5X77_01945	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5X77_01950	COG0488	(ABC) transporter
K5X77_01955	COG0366	Alpha amylase catalytic
K5X77_01960	COG0366	Alpha amylase catalytic
K5X77_01975	COG0617	tRNA 3'-terminal CCA addition
K5X77_01980	COG1694	Mazg nucleotide pyrophosphohydrolase
K5X77_01985	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5X77_02010	COG0456	acetyltransferase
K5X77_02010	COG1846	Transcriptional regulator
K5X77_02015	COG0577	efflux transmembrane transporter activity
K5X77_02020	COG1136	(ABC) transporter
K5X77_02025	COG1012	belongs to the aldehyde dehydrogenase family
K5X77_02035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X77_02050	COG3833	ABC-type maltose transport systems, permease component
K5X77_02055	COG1175	transmembrane transport
K5X77_02060	COG2182	Extracellular solute-binding protein
K5X77_02070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X77_02075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5X77_02080	COG1323	Belongs to the UPF0348 family
K5X77_02085	COG0492	ferredoxin-NADP+ reductase activity
K5X77_02090	COG0534	Mate efflux family protein
K5X77_02095	COG1132	(ABC) transporter
K5X77_02100	COG1132	(ABC) transporter
K5X77_02105	COG3763	UPF0154 protein
K5X77_02110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5X77_02115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5X77_02125	COG1609	Transcriptional regulator
K5X77_02135	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K5X77_02140	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5X77_02140	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5X77_02145	COG0484	heat shock protein binding
K5X77_02150	COG0443	Heat shock 70 kDa protein
K5X77_02155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5X77_02160	COG1420	regulation of RNA biosynthetic process
K5X77_02165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5X77_02170	COG0196	riboflavin kinase activity
K5X77_02175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5X77_02185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5X77_02200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K5X77_02205	COG0195	Participates in both transcription termination and antitermination
K5X77_02210	COG0779	Required for maturation of 30S ribosomal subunits
K5X77_02220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5X77_02230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5X77_02240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5X77_02295	COG4974	Belongs to the 'phage' integrase family
K5X77_02305	COG0481	GTPase activity
K5X77_02315	COG0542	response to heat
K5X77_02330	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5X77_02335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5X77_02340	COG2384	SAM-dependent methyltransferase
K5X77_02355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5X77_02360	COG0358	DNA primase activity
K5X77_02365	COG0751	glycine-tRNA ligase activity
K5X77_02370	COG0752	glycyl-tRNA synthetase alpha subunit
K5X77_02375	COG1381	Involved in DNA repair and RecF pathway recombination
K5X77_02380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5X77_02385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5X77_02390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5X77_02400	COG1702	phosphate starvation-inducible protein PhoH
K5X77_02405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5X77_02410	COG0025	NhaP-type Na H and K H
K5X77_02425	COG1674	ftsk spoiiie
K5X77_02425	COG1280	lysine exporter protein (LysE YggA)
K5X77_02440	COG1464	Belongs to the NlpA lipoprotein family
K5X77_02445	COG2011	ABC-type metal ion transport system permease component
K5X77_02450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5X77_02460	COG1393	Belongs to the ArsC family
K5X77_02465	COG0772	Belongs to the SEDS family
K5X77_02485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5X77_02490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5X77_02495	COG0009	L-threonylcarbamoyladenylate synthase
K5X77_02500	COG2890	protein-(glutamine-N5) methyltransferase activity
K5X77_02505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5X77_02510	COG1435	thymidine kinase activity
K5X77_02515	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5X77_02520	COG2190	(PTS) system
K5X77_02520	COG1263	PTS System
K5X77_02520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_02525	COG0336	Belongs to the RNA methyltransferase TrmD family
K5X77_02530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5X77_02535	COG1837	Belongs to the UPF0109 family
K5X77_02540	COG0228	four-way junction DNA binding
K5X77_02545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5X77_02550	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K5X77_02555	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K5X77_02560	COG0436	Aminotransferase
K5X77_02565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5X77_02570	COG0187	DNA topoisomerase II activity
K5X77_02575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5X77_02580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5X77_02585	COG0686	Belongs to the AlaDH PNT family
K5X77_02595	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K5X77_02600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5X77_02605	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5X77_02610	COG4974	Belongs to the 'phage' integrase family
K5X77_02620	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K5X77_02625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5X77_02630	COG0758	DNA mediated transformation
K5X77_02635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5X77_02650	COG0793	Belongs to the peptidase S41A family
K5X77_02650	COG3409	Peptidoglycan-binding domain 1 protein
K5X77_02660	COG0205	6-phosphofructokinase activity
K5X77_02665	COG0587	DNA-directed DNA polymerase activity
K5X77_02675	COG2814	Major facilitator Superfamily
K5X77_02680	COG2723	6-phospho-beta-galactosidase activity
K5X77_02685	COG1307	EDD domain protein, DegV family
K5X77_02695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5X77_02705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5X77_02715	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5X77_02735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5X77_02740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5X77_02750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5X77_02755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5X77_02765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5X77_02780	COG0668	transmembrane transport
K5X77_02785	COG1363	Peptidase, m42
K5X77_02790	COG2233	PERMEase
K5X77_02795	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
K5X77_02795	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K5X77_02810	COG3052	prosthetic group binding
K5X77_02820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5X77_02825	COG0583	DNA-binding transcription factor activity
K5X77_02835	COG4608	Belongs to the ABC transporter superfamily
K5X77_02840	COG0444	Belongs to the ABC transporter superfamily
K5X77_02845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X77_02850	COG0601	transmembrane transport
K5X77_02855	COG0747	negative chemotaxis
K5X77_02860	COG1473	amidohydrolase
K5X77_02870	COG0622	Phosphoesterase
K5X77_02875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5X77_02880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K5X77_02885	COG0072	phenylalanine-tRNA ligase activity
K5X77_02885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5X77_02890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5X77_02895	COG1733	regulation of RNA biosynthetic process
K5X77_02905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5X77_02910	COG1254	Belongs to the acylphosphatase family
K5X77_02915	COG0706	membrane insertase activity
K5X77_02925	COG5002	protein histidine kinase activity
K5X77_02930	COG0745	RESPONSE REGULATOR receiver
K5X77_02935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5X77_02940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5X77_02950	COG1484	DNA-dependent DNA replication
K5X77_02960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5X77_02965	COG0237	dephospho-CoA kinase activity
K5X77_02970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5X77_02985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5X77_03000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5X77_03005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5X77_03020	COG3091	SprT-like family
K5X77_03025	COG2183	response to ionizing radiation
K5X77_03060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5X77_03065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5X77_03070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5X77_03075	COG4989	oxidoreductase activity
K5X77_03085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5X77_03090	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5X77_03095	COG1876	peptidase activity
K5X77_03105	COG4129	membrane
K5X77_03115	COG2268	Band 7 protein
K5X77_03145	COG3343	RNA polymerase activity
K5X77_03155	COG0095	Lipoate-protein ligase
K5X77_03160	COG1078	dGTPase activity
K5X77_03180	COG1610	YqeY-like protein
K5X77_03190	COG0735	belongs to the Fur family
K5X77_03195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5X77_03200	COG1122	ATPase activity
K5X77_03205	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5X77_03220	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K5X77_03225	COG1950	PFAM Membrane protein of
K5X77_03280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5X77_03285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5X77_03290	COG0581	inorganic phosphate transmembrane transporter activity
K5X77_03295	COG0573	inorganic phosphate transmembrane transporter activity
K5X77_03300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5X77_03305	COG2177	Part of the ABC transporter FtsEX involved in
K5X77_03310	COG2884	Cell division ATP-binding protein ftsE
K5X77_03320	COG0653	protein targeting
K5X77_03335	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K5X77_03340	COG2267	carboxylic ester hydrolase activity
K5X77_03350	COG1739	Uncharacterized protein family UPF0029
K5X77_03355	COG2188	Transcriptional regulator
K5X77_03360	COG1074	ATP-dependent DNA helicase activity
K5X77_03365	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K5X77_03370	COG0681	Belongs to the peptidase S26 family
K5X77_03380	COG4224	UPF0291 protein
K5X77_03385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5X77_03400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5X77_03405	COG0546	phosphoglycolate phosphatase activity
K5X77_03410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5X77_03415	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5X77_03445	COG0517	IMP dehydrogenase activity
K5X77_03480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5X77_03490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5X77_03500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5X77_03505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5X77_03510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5X77_03515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5X77_03520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5X77_03525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5X77_03530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5X77_03535	COG0356	it plays a direct role in the translocation of protons across the membrane
K5X77_03540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5X77_03545	COG0557	exoribonuclease II activity
K5X77_03555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5X77_03575	COG0709	Synthesizes selenophosphate from selenide and ATP
K5X77_03590	COG2261	transglycosylase associated protein
K5X77_03635	COG1098	S1 RNA binding domain
K5X77_03645	COG0492	ferredoxin-NADP+ reductase activity
K5X77_03650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5X77_03660	COG0647	UMP catabolic process
K5X77_03665	COG4470	Protein conserved in bacteria
K5X77_03675	COG2365	Tyrosine phosphatase family
K5X77_03690	COG4166	transmembrane transport
K5X77_03695	COG4608	Belongs to the ABC transporter superfamily
K5X77_03700	COG0444	Belongs to the ABC transporter superfamily
K5X77_03705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X77_03710	COG0601	transmembrane transport
K5X77_03730	COG3118	belongs to the thioredoxin family
K5X77_03735	COG1193	negative regulation of DNA recombination
K5X77_03750	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5X77_03755	COG5294	Protein conserved in bacteria
K5X77_03765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5X77_03775	COG3906	Belongs to the UPF0473 family
K5X77_03785	COG4472	Bacterial protein of unknown function (DUF965)
K5X77_03790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5X77_03795	COG0589	response to stress
K5X77_03800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5X77_03805	COG1363	Peptidase, m42
K5X77_03815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5X77_03820	COG0510	thiamine kinase activity
K5X77_03830	COG1131	(ABC) transporter
K5X77_03835	COG0537	adenosine 5'-monophosphoramidase activity
K5X77_03845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5X77_03855	COG3481	metal-dependent phosphohydrolase, HD sub domain
K5X77_03860	COG3679	Belongs to the UPF0342 family
K5X77_03865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5X77_03870	COG0564	pseudouridine synthase activity
K5X77_03880	COG1438	arginine binding
K5X77_03885	COG0018	arginyl-trna synthetase
K5X77_03890	COG4708	membrane
K5X77_03900	COG1116	anion transmembrane transporter activity
K5X77_03905	COG4521	taurine ABC transporter
K5X77_03910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5X77_03915	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5X77_03920	COG2391	methyltransferase activity
K5X77_03925	COG0583	DNA-binding transcription factor activity
K5X77_03930	COG1597	lipid kinase activity
K5X77_03935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5X77_03940	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5X77_03945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5X77_03950	COG0742	ribosomal rna small subunit methyltransferase
K5X77_03955	COG4471	UPF0298 protein
K5X77_03970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K5X77_03975	COG0772	Belongs to the SEDS family
K5X77_03980	COG4838	Belongs to the UPF0358 family
K5X77_03990	COG2116	formate transmembrane transporter activity
K5X77_03995	COG1464	Belongs to the NlpA lipoprotein family
K5X77_04000	COG2011	ABC-type metal ion transport system permease component
K5X77_04010	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5X77_04015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5X77_04020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5X77_04025	COG1116	anion transmembrane transporter activity
K5X77_04035	COG0352	thiamine-phosphate diphosphorylase activity
K5X77_04040	COG0351	phosphomethylpyrimidine kinase
K5X77_04055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5X77_04060	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5X77_04070	COG1714	RDD family
K5X77_04080	COG4703	Protein of unknown function (DUF1797)
K5X77_04090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5X77_04095	COG3716	PTS system mannose fructose sorbose family IID component
K5X77_04105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_04110	COG1105	Belongs to the carbohydrate kinase PfkB family
K5X77_04115	COG3684	Belongs to the aldolase LacD family
K5X77_04120	COG2222	sugar isomerase
K5X77_04125	COG2188	Transcriptional regulator
K5X77_04130	COG2084	Dehydrogenase
K5X77_04140	COG0438	transferase activity, transferring glycosyl groups
K5X77_04145	COG0438	transferase activity, transferring glycosyl groups
K5X77_04150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5X77_04155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5X77_04165	COG0542	response to heat
K5X77_04175	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K5X77_04180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5X77_04185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5X77_04190	COG0584	glycerophosphoryl diester phosphodiesterase
K5X77_04200	COG1278	Cold shock
K5X77_04205	COG2003	Belongs to the UPF0758 family
K5X77_04210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X77_04215	COG0285	dihydrofolate synthase activity
K5X77_04220	COG0525	valine-tRNA ligase activity
K5X77_04225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K5X77_04230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5X77_04240	COG1104	cysteine desulfurase activity
K5X77_04245	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K5X77_04250	COG0561	phosphatase activity
K5X77_04255	COG1801	Protein of unknown function DUF72
K5X77_04270	COG0166	Belongs to the GPI family
K5X77_04275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5X77_04280	COG2081	HI0933 family
K5X77_04300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X77_04305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5X77_04315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5X77_04320	COG1368	sulfuric ester hydrolase activity
K5X77_04330	COG0765	amino acid transport
K5X77_04335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5X77_04345	COG1368	sulfuric ester hydrolase activity
K5X77_04350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5X77_04355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K5X77_04365	COG0500	methyltransferase
K5X77_04370	COG3142	Participates in the control of copper homeostasis
K5X77_04375	COG2239	Acts as a magnesium transporter
K5X77_04380	COG0564	pseudouridine synthase activity
K5X77_04385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5X77_04390	COG2357	RelA SpoT domain protein
K5X77_04395	COG4116	CYTH
K5X77_04405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5X77_04410	COG0640	Transcriptional regulator
K5X77_04415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5X77_04420	COG1136	(ABC) transporter
K5X77_04420	COG0577	efflux transmembrane transporter activity
K5X77_04425	COG0577	efflux transmembrane transporter activity
K5X77_04425	COG1136	(ABC) transporter
K5X77_04435	COG1278	Cold shock
K5X77_04440	COG1879	ABC-type sugar transport system periplasmic component
K5X77_04445	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5X77_04450	COG1129	ABC transporter
K5X77_04460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X77_04465	COG1609	Transcriptional regulator
K5X77_04475	COG2207	Transcriptional regulator
K5X77_04480	COG1253	flavin adenine dinucleotide binding
K5X77_04485	COG0628	permease
K5X77_04505	COG3557	Belongs to the UPF0374 family
K5X77_04550	COG0392	lysyltransferase activity
K5X77_04550	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K5X77_04555	COG1194	a g-specific adenine glycosylase
K5X77_04560	COG2137	regulation of response to DNA damage stimulus
K5X77_04590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5X77_04610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5X77_04615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5X77_04620	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5X77_04625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5X77_04635	COG1316	TRANSCRIPTIONal
K5X77_04645	COG0438	transferase activity, transferring glycosyl groups
K5X77_04650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5X77_04670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5X77_04680	COG4464	protein tyrosine phosphatase activity
K5X77_04685	COG0489	protein tyrosine kinase activity
K5X77_04690	COG3944	biosynthesis protein
K5X77_04725	COG0463	Glycosyl transferase, family 2
K5X77_04725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X77_04730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5X77_04735	COG0463	Glycosyl transferase, family 2
K5X77_04735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X77_04740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5X77_04745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X77_04750	COG1682	transport, permease protein
K5X77_04755	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K5X77_04760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X77_04765	COG1134	teichoic acid transport
K5X77_04770	COG1316	TRANSCRIPTIONal
K5X77_04775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5X77_04780	COG1295	ribonuclease BN
K5X77_04785	COG0024	Methionine aminopeptidase
K5X77_04790	COG0716	FMN binding
K5X77_04800	COG2309	aminopeptidase activity
K5X77_04825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5X77_04835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5X77_04840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5X77_04840	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5X77_04850	COG0673	inositol 2-dehydrogenase activity
K5X77_04870	COG5503	Protein of unknown function (DUF1447)
K5X77_04880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5X77_04885	COG1940	carbohydrate kinase activity
K5X77_04890	COG0705	Rhomboid family
K5X77_04890	COG0457	Tetratricopeptide repeat
K5X77_04900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5X77_04905	COG0768	penicillin binding
K5X77_04910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5X77_04920	COG1185	polyribonucleotide nucleotidyltransferase activity
K5X77_04925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5X77_04930	COG0242	peptide deformylase activity
K5X77_04940	COG2207	Transcriptional regulator
K5X77_04950	COG0737	Belongs to the 5'-nucleotidase family
K5X77_04955	COG0656	L-ascorbic acid biosynthetic process
K5X77_04960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5X77_04970	COG3842	ATPase activity
K5X77_04980	COG2207	Transcriptional regulator
K5X77_04980	COG4753	response regulator
K5X77_04985	COG2972	Histidine kinase
K5X77_04990	COG0459	protein refolding
K5X77_04995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K5X77_05000	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5X77_05005	COG0488	(ABC) transporter
K5X77_05010	COG1609	Transcriptional regulator
K5X77_05020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5X77_05025	COG4109	DRTGG domain
K5X77_05030	COG2814	Major facilitator Superfamily
K5X77_05040	COG1132	(ABC) transporter
K5X77_05045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5X77_05050	COG0204	Acyl-transferase
K5X77_05055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5X77_05060	COG2827	Endonuclease containing a URI domain
K5X77_05080	COG1959	2 iron, 2 sulfur cluster binding
K5X77_05085	COG1288	antiporter activity
K5X77_05090	COG2376	Dihydroxyacetone kinase
K5X77_05095	COG1461	Dihydroxyacetone kinase
K5X77_05100	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K5X77_05110	COG2376	Dihydroxyacetone kinase
K5X77_05115	COG1309	transcriptional regulator
K5X77_05130	COG2390	Transcriptional regulator
K5X77_05135	COG3634	alkyl hydroperoxide reductase activity
K5X77_05140	COG0450	alkyl hydroperoxide reductase
K5X77_05150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5X77_05155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5X77_05160	COG0183	Belongs to the thiolase family
K5X77_05165	COG1136	(ABC) transporter
K5X77_05170	COG0577	efflux transmembrane transporter activity
K5X77_05190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5X77_05335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5X77_05340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5X77_05345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5X77_05350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5X77_05355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5X77_05360	COG0037	tRNA processing
K5X77_05365	COG1098	S1 RNA binding domain
K5X77_05375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5X77_05380	COG2244	polysaccharide biosynthetic process
K5X77_05385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5X77_05390	COG0193	aminoacyl-tRNA hydrolase activity
K5X77_05400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5X77_05405	COG1780	Probably involved in ribonucleotide reductase function
K5X77_05410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5X77_05415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5X77_05425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5X77_05430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5X77_05435	COG4684	Psort location CytoplasmicMembrane, score
K5X77_05440	COG4862	establishment of competence for transformation
K5X77_05445	COG1393	Belongs to the ArsC family
K5X77_05450	COG0180	Tryptophanyl-tRNA synthetase
K5X77_05455	COG0095	Lipoate-protein ligase
K5X77_05460	COG1234	tRNA 3'-trailer cleavage
K5X77_05465	COG1363	Peptidase, m42
K5X77_05475	COG1328	CTP reductase activity
K5X77_05480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5X77_05485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5X77_05490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5X77_05495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K5X77_05500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K5X77_05510	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5X77_05550	COG0572	uridine kinase
K5X77_05555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5X77_05590	COG4537	Required for transformation and DNA binding
K5X77_05595	COG1459	type II secretion system
K5X77_05600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5X77_05605	COG0217	transcriptional regulatory protein
K5X77_05615	COG3688	RNA-binding protein containing a PIN domain
K5X77_05625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K5X77_05630	COG0215	cysteine-tRNA ligase activity
K5X77_05635	COG1045	serine acetyltransferase
K5X77_05640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5X77_05645	COG4956	integral membrane protein (PIN domain superfamily)
K5X77_05655	COG0756	dUTP diphosphatase activity
K5X77_05660	COG1937	Protein conserved in bacteria
K5X77_05665	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5X77_05675	COG1187	pseudouridine synthase activity
K5X77_05680	COG2244	polysaccharide biosynthetic process
K5X77_05685	COG1363	Peptidase, m42
K5X77_05695	COG4493	Belongs to the UPF0637 family
K5X77_05700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5X77_05705	COG1605	Chorismate mutase
K5X77_05705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5X77_05720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X77_05725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5X77_05730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5X77_05735	COG0124	histidyl-tRNA synthetase
K5X77_05740	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5X77_05740	COG3103	Sh3 type 3 domain protein
K5X77_05740	COG4991	sh3 domain protein
K5X77_05745	COG1490	D-aminoacyl-tRNA deacylase activity
K5X77_05775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5X77_05780	COG2264	protein methyltransferase activity
K5X77_05790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5X77_05805	COG0589	response to stress
K5X77_05810	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5X77_05815	COG0737	Belongs to the 5'-nucleotidase family
K5X77_05820	COG3639	organic phosphonate transmembrane transporter activity
K5X77_05840	COG3579	cysteine-type endopeptidase activity
K5X77_05855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5X77_05870	COG3859	Proton-coupled thiamine transporter YuaJ
K5X77_05875	COG2076	Multidrug Resistance protein
K5X77_05880	COG2076	Multidrug Resistance protein
K5X77_05895	COG1482	cell wall glycoprotein biosynthetic process
K5X77_05910	COG0395	ABC-type sugar transport system, permease component
K5X77_05915	COG4209	transmembrane transport
K5X77_05945	COG2723	6-phospho-beta-galactosidase activity
K5X77_05955	COG0456	acetyltransferase
K5X77_05970	COG3291	Pkd domain containing protein
K5X77_05970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K5X77_05985	COG0488	(ABC) transporter
K5X77_05995	COG0477	Major facilitator Superfamily
K5X77_06005	COG2003	Belongs to the UPF0758 family
K5X77_06020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5X77_06030	COG3973	AAA domain
K5X77_06050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5X77_06055	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K5X77_06075	COG0863	Belongs to the N(4) N(6)-methyltransferase family
K5X77_06080	COG0863	Belongs to the N(4) N(6)-methyltransferase family
K5X77_06135	COG1201	RNA secondary structure unwinding
K5X77_06150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5X77_06155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5X77_06160	COG0101	tRNA pseudouridine synthase activity
K5X77_06170	COG1122	ATPase activity
K5X77_06175	COG1122	ATPase activity
K5X77_06180	COG0203	ribosomal protein L17
K5X77_06185	COG0202	RNA polymerase activity
K5X77_06190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5X77_06195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5X77_06200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5X77_06210	COG0563	adenylate kinase activity
K5X77_06215	COG0201	protein transport
K5X77_06220	COG0200	Binds to the 23S rRNA
K5X77_06225	COG1841	ribosomal large subunit assembly
K5X77_06230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5X77_06240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5X77_06245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5X77_06250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5X77_06255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5X77_06260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5X77_06265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5X77_06270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5X77_06275	COG0255	Belongs to the universal ribosomal protein uL29 family
K5X77_06280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5X77_06285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5X77_06290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5X77_06300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5X77_06305	COG0089	rRNA binding
K5X77_06310	COG0088	Forms part of the polypeptide exit tunnel
K5X77_06315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5X77_06320	COG0051	transcription antitermination factor activity, RNA binding
K5X77_06330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5X77_06335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5X77_06340	COG0049	tRNA binding
K5X77_06345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5X77_06350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5X77_06355	COG0813	purine-nucleoside phosphorylase activity
K5X77_06360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K5X77_06365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5X77_06370	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5X77_06375	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5X77_06380	COG3845	ABC transporter
K5X77_06385	COG1744	ABC transporter substrate-binding protein PnrA-like
K5X77_06390	COG0295	cytidine deaminase activity
K5X77_06395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5X77_06410	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5X77_06420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K5X77_06420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K5X77_06440	COG4939	FMN-binding domain protein
K5X77_06460	COG0488	(ABC) transporter
K5X77_06470	COG0305	Participates in initiation and elongation during chromosome replication
K5X77_06475	COG0359	binds to the 23S rRNA
K5X77_06480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5X77_06490	COG0360	Binds together with S18 to 16S ribosomal RNA
K5X77_06500	COG0187	DNA topoisomerase II activity
K5X77_06505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5X77_06510	COG2501	S4 domain
K5X77_06525	COG1028	Short-chain dehydrogenase reductase Sdr
K5X77_06530	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K5X77_06535	COG1414	Transcriptional regulator
K5X77_06540	COG0800	Aldolase
K5X77_06545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X77_06550	COG5492	domain, Protein
K5X77_06565	COG3716	PTS system mannose fructose sorbose family IID component
K5X77_06570	COG3715	PTS system
K5X77_06580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K5X77_06585	COG2188	Transcriptional regulator
K5X77_06590	COG0592	DNA-directed DNA polymerase activity
K5X77_06595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5X77_06600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5X77_06610	COG0706	membrane insertase activity
K5X77_06620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5X77_06625	COG0445	tRNA wobble uridine modification
K5X77_06635	COG3732	PTS system glucitol sorbitol-specific
K5X77_06640	COG3730	PTS system glucitol sorbitol-specific
K5X77_06665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5X77_06670	COG0022	dehydrogenase e1 component
K5X77_06670	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X77_06675	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X77_06695	COG0357	Ribosomal RNA small subunit methyltransferase G
K5X77_06700	COG1192	Involved in chromosome partitioning
K5X77_06705	COG1475	DNA binding
K5X77_06710	COG4481	Protein conserved in bacteria
K5X77_06715	COG0012	GTP binding
K5X77_06725	COG0516	GMP reductase activity
K5X77_06725	COG0517	IMP dehydrogenase activity
K5X77_06730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5X77_06735	COG1686	Belongs to the peptidase S11 family
K5X77_06750	COG0406	alpha-ribazole phosphatase activity
K5X77_06810	COG4463	regulation of RNA biosynthetic process
K5X77_06815	COG0542	response to heat
K5X77_06825	COG0826	peptidase U32
K5X77_06830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5X77_06835	COG1271	oxidase subunit
K5X77_06840	COG1294	oxidase, subunit
K5X77_06845	COG4988	ABC transporter
K5X77_06850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5X77_06860	COG0142	geranyltranstransferase activity
K5X77_06875	COG0561	phosphatase activity
K5X77_06880	COG0280	phosphate acetyltransferase
K5X77_06885	COG0802	atpase or kinase
K5X77_06890	COG0737	Belongs to the 5'-nucleotidase family
K5X77_06900	COG2176	DNA-directed DNA polymerase activity
K5X77_06905	COG0708	Exodeoxyribonuclease III
K5X77_06910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5X77_06915	COG0604	alcohol dehydrogenase
K5X77_06925	COG3842	ATPase activity
K5X77_06930	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5X77_06935	COG1177	transmembrane transport
K5X77_06940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5X77_06945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5X77_06950	COG1263	PTS System
K5X77_06950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_06950	COG2190	(PTS) system
K5X77_06955	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5X77_06960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5X77_06965	COG1121	(ABC) transporter
K5X77_06970	COG1121	(ABC) transporter
K5X77_06975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5X77_06985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5X77_06995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5X77_07020	COG1970	mechanosensitive ion channel activity
K5X77_07025	COG0612	Peptidase, M16
K5X77_07030	COG0612	Peptidase, M16
K5X77_07040	COG1426	Protein conserved in bacteria
K5X77_07045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5X77_07050	COG1546	Belongs to the CinA family
K5X77_07050	COG1058	Belongs to the CinA family
K5X77_07055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5X77_07060	COG1418	mRNA catabolic process
K5X77_07080	COG1674	ftsk spoiiie
K5X77_07090	COG2946	Replication initiation factor
K5X77_07120	COG0741	lytic transglycosylase activity
K5X77_07120	COG0791	NLP P60 protein
K5X77_07185	COG1278	Cold shock
K5X77_07215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K5X77_07220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_07220	COG1263	PTS System
K5X77_07225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X77_07230	COG1737	Transcriptional regulator
K5X77_07235	COG3973	AAA domain
K5X77_07240	COG0745	RESPONSE REGULATOR receiver
K5X77_07245	COG5002	protein histidine kinase activity
K5X77_07260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5X77_07265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5X77_07280	COG2003	Belongs to the UPF0758 family
K5X77_07310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5X77_07325	COG0768	penicillin binding
K5X77_07350	COG0625	glutathione transferase activity
K5X77_07360	COG0590	tRNA wobble adenosine to inosine editing
K5X77_07365	COG2190	(PTS) system
K5X77_07365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_07365	COG1263	PTS System
K5X77_07370	COG3711	transcriptional antiterminator
K5X77_07375	COG2723	6-phospho-beta-galactosidase activity
K5X77_07385	COG1285	pathogenesis
K5X77_07390	COG2814	Major facilitator Superfamily
K5X77_07395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5X77_07395	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5X77_07400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_07400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5X77_07410	COG3715	PTS system
K5X77_07415	COG3716	PTS system mannose fructose sorbose family IID component
K5X77_07445	COG4720	Psort location CytoplasmicMembrane, score
K5X77_07450	COG1122	ATPase activity
K5X77_07470	COG0402	S-adenosylhomocysteine deaminase activity
K5X77_07480	COG0737	Belongs to the 5'-nucleotidase family
K5X77_07485	COG2246	polysaccharide biosynthetic process
K5X77_07490	COG0463	Glycosyl transferase, family 2
K5X77_07500	COG4619	ABC transporter
K5X77_07505	COG0390	transport system, permease component
K5X77_07515	COG0583	DNA-binding transcription factor activity
K5X77_07525	COG3711	transcriptional antiterminator
K5X77_07525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5X77_07535	COG3730	PTS system glucitol sorbitol-specific
K5X77_07540	COG3732	PTS system glucitol sorbitol-specific
K5X77_07560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5X77_07570	COG2910	NAD(P)H-binding
K5X77_07575	COG1733	regulation of RNA biosynthetic process
K5X77_07580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5X77_07585	COG2233	PERMEase
K5X77_07590	COG2190	(PTS) system
K5X77_07590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_07590	COG1263	PTS System
K5X77_07595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5X77_07600	COG1609	Transcriptional regulator
K5X77_07620	COG3119	arylsulfatase activity
K5X77_07625	COG0641	radical SAM
K5X77_07630	COG0668	transmembrane transport
K5X77_07670	COG0156	8-amino-7-oxononanoate synthase activity
K5X77_07675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5X77_07685	COG1979	alcohol dehydrogenase
K5X77_07695	COG0383	alpha-mannosidase activity
K5X77_07725	COG1054	Belongs to the UPF0176 family
K5X77_07730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5X77_07735	COG2094	Belongs to the DNA glycosylase MPG family
K5X77_07745	COG1378	Sugar-specific transcriptional regulator TrmB
K5X77_07760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5X77_07760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5X77_07760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5X77_07765	COG1105	Belongs to the carbohydrate kinase PfkB family
K5X77_07770	COG1349	DNA-binding transcription factor activity
K5X77_07775	COG1692	metallophosphoesterase
K5X77_07785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5X77_07795	COG0424	maF-like protein
K5X77_07815	COG1418	mRNA catabolic process
K5X77_07830	COG1346	cytolysis
K5X77_07835	COG0517	IMP dehydrogenase activity
K5X77_07840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5X77_07845	COG1597	lipid kinase activity
K5X77_07860	COG0561	phosphatase activity
K5X77_07865	COG0745	RESPONSE REGULATOR receiver
K5X77_07870	COG5002	protein histidine kinase activity
K5X77_07870	COG3850	Histidine kinase
K5X77_07875	COG4476	Belongs to the UPF0223 family
K5X77_07880	COG0483	inositol monophosphate 1-phosphatase activity
K5X77_07885	COG1217	gtp-binding protein TYPA
K5X77_07910	COG0191	fructose-bisphosphate aldolase activity
K5X77_07925	COG2706	6-phosphogluconolactonase activity
K5X77_07935	COG0628	permease
K5X77_07945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5X77_07965	COG2824	Alkylphosphonate utilization operon protein PhnA
K5X77_07970	COG2738	Putative neutral zinc metallopeptidase
K5X77_07980	COG2508	Transcriptional regulator
K5X77_07985	COG0590	tRNA wobble adenosine to inosine editing
K5X77_08010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5X77_08015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5X77_08020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5X77_08025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5X77_08030	COG3870	Protein conserved in bacteria
K5X77_08035	COG0470	DNA polymerase III
K5X77_08040	COG1774	PSP1 C-terminal conserved region
K5X77_08045	COG4467	Involved in initiation control of chromosome replication
K5X77_08090	COG1132	(ABC) transporter
K5X77_08095	COG1132	(ABC) transporter
K5X77_08100	COG4475	Protein of unknown function (DUF436)
K5X77_08105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5X77_08115	COG0765	amino acid transport
K5X77_08125	COG4717	serine-type aminopeptidase activity
K5X77_08135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5X77_08140	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5X77_08150	COG1596	polysaccharide export
K5X77_08150	COG1555	photosystem II stabilization
K5X77_08155	COG2131	deaminase
K5X77_08160	COG0658	competence protein
K5X77_08160	COG2333	competence protein COMEC
K5X77_08165	COG1466	dna polymerase III delta subunit
K5X77_08170	COG0268	Binds directly to 16S ribosomal RNA
K5X77_08175	COG0306	phosphate transporter
K5X77_08180	COG1392	Phosphate transport regulator
K5X77_08185	COG2217	Heavy metal translocating P-type atpase
K5X77_08190	COG1968	undecaprenyl-diphosphatase activity
K5X77_08195	COG2207	Transcriptional regulator
K5X77_08200	COG0673	inositol 2-dehydrogenase activity
K5X77_08210	COG1082	Xylose isomerase domain protein TIM barrel
K5X77_08215	COG0673	inositol 2-dehydrogenase activity
K5X77_08220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5X77_08250	COG1732	Glycine betaine
K5X77_08255	COG1174	glycine betaine transport
K5X77_08260	COG0436	Aminotransferase
K5X77_08280	COG0110	maltose O-acetyltransferase activity
K5X77_08285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5X77_08295	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5X77_08305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5X77_08305	COG0574	Belongs to the PEP-utilizing enzyme family
K5X77_08310	COG0584	glycerophosphoryl diester phosphodiesterase
K5X77_08315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5X77_08315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5X77_08320	COG0084	hydrolase, TatD family'
K5X77_08325	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K5X77_08330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5X77_08335	COG3842	ATPase activity
K5X77_08340	COG1803	Methylglyoxal synthase
K5X77_08345	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5X77_08350	COG0827	DNA restriction-modification system
K5X77_08355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5X77_08360	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X77_08365	COG4605	iron ion homeostasis
K5X77_08370	COG4604	ABC transporter, ATP-binding protein
K5X77_08375	COG4607	ABC-type enterochelin transport system periplasmic component
K5X77_08390	COG1942	4-Oxalocrotonate Tautomerase
K5X77_08395	COG1349	DNA-binding transcription factor activity
K5X77_08400	COG1012	belongs to the aldehyde dehydrogenase family
K5X77_08405	COG3718	enzyme involved in inositol metabolism
K5X77_08410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X77_08415	COG3962	Belongs to the TPP enzyme family
K5X77_08420	COG0673	inositol 2-dehydrogenase activity
K5X77_08425	COG1082	Xylose isomerase domain protein TIM barrel
K5X77_08430	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5X77_08435	COG0673	inositol 2-dehydrogenase activity
K5X77_08450	COG0632	four-way junction helicase activity
K5X77_08455	COG2255	four-way junction helicase activity
K5X77_08460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5X77_08465	COG0343	queuine tRNA-ribosyltransferase activity
K5X77_08470	COG1862	Preprotein translocase
K5X77_08480	COG1012	belongs to the aldehyde dehydrogenase family
K5X77_08480	COG1454	alcohol dehydrogenase
K5X77_08505	COG1164	Oligoendopeptidase f
K5X77_08515	COG4466	Protein conserved in bacteria
K5X77_08520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5X77_08525	COG2188	Transcriptional regulator
K5X77_08535	COG1446	asparaginase
K5X77_08570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K5X77_08580	COG2226	methyltransferase
K5X77_08620	COG2801	Transposase and inactivated derivatives
K5X77_08625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5X77_08630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5X77_08645	COG1959	2 iron, 2 sulfur cluster binding
K5X77_08650	COG2188	Transcriptional regulator
K5X77_08655	COG0366	Alpha amylase catalytic
K5X77_08660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X77_08660	COG1263	PTS System
K5X77_08670	COG1122	ATPase activity
K5X77_08685	COG0789	Transcriptional regulator
K5X77_08695	COG2188	Transcriptional regulator
K5X77_08700	COG2723	6-phospho-beta-galactosidase activity
K5X77_08705	COG0741	lytic transglycosylase activity
K5X77_08705	COG0739	heme binding
K5X77_08705	COG1196	nuclear chromosome segregation
K5X77_08710	COG0726	polysaccharide deacetylase
K5X77_08730	COG3284	Transcriptional regulator
K5X77_08735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5X77_08740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5X77_08745	COG0022	dehydrogenase e1 component
K5X77_08750	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X77_08755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5X77_08755	COG0519	Catalyzes the synthesis of GMP from XMP
K5X77_08760	COG1072	(Pantothenic acid kinase))
K5X77_08765	COG1607	acyl-coa hydrolase
K5X77_08775	COG2813	Specifically methylates the guanine in position
K5X77_08780	COG0052	Belongs to the universal ribosomal protein uS2 family
K5X77_08785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5X77_08790	COG0528	UMP kinase activity
K5X77_08795	COG0233	cytoplasmic translational termination
K5X77_08805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5X77_08810	COG4589	Belongs to the CDS family
K5X77_08815	COG0750	zinc metalloprotease
K5X77_08820	COG0442	prolyl-tRNA aminoacylation
K5X77_08825	COG2176	DNA-directed DNA polymerase activity
K5X77_08830	COG0735	belongs to the Fur family
K5X77_08910	COG0322	excinuclease ABC activity
K5X77_08920	COG4152	abc transporter atp-binding protein
K5X77_08925	COG1668	transmembrane transport
K5X77_08930	COG0210	DNA helicase
K5X77_08935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5X77_08940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5X77_08945	COG0154	amidase activity
K5X77_08950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5X77_08955	COG1597	lipid kinase activity
K5X77_08960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5X77_08980	COG0488	(ABC) transporter
K5X77_09000	COG2226	methyltransferase
K5X77_09010	COG0456	acetyltransferase
K5X77_09035	COG0456	acetyltransferase
K5X77_09050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5X77_09075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5X77_09090	COG2608	mercury ion transmembrane transporter activity
K5X77_09095	COG1114	Component of the transport system for branched-chain amino acids
K5X77_09110	COG1132	(ABC) transporter
K5X77_09120	COG1686	Belongs to the peptidase S11 family
K5X77_09125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5X77_09130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5X77_09135	COG0254	rRNA binding
K5X77_09140	COG3942	CHAP domain
K5X77_09140	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5X77_09145	COG2017	converts alpha-aldose to the beta-anomer
K5X77_09150	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K5X77_09160	COG0589	response to stress
K5X77_09175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5X77_09185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5X77_09190	COG0006	proline dipeptidase activity
K5X77_09195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5X77_09200	COG1302	Protein conserved in bacteria
K5X77_09205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5X77_09210	COG1570	exodeoxyribonuclease VII activity
K5X77_09215	COG1722	exodeoxyribonuclease VII activity
K5X77_09220	COG0142	geranyltranstransferase activity
K5X77_09225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K5X77_09230	COG1438	arginine binding
K5X77_09235	COG0497	DNA recombination
K5X77_09250	COG2001	Belongs to the MraZ family
K5X77_09255	COG0275	rRNA processing
K5X77_09265	COG0768	penicillin binding
K5X77_09270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5X77_09275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5X77_09280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5X77_09290	COG0849	cell division
K5X77_09300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5X77_09305	COG1799	cell septum assembly
K5X77_09315	COG2302	S4 RNA-binding domain
K5X77_09320	COG3599	regulation of cell shape
K5X77_09325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5X77_09350	COG1203	CRISPR-associated helicase, Cas3
K5X77_09360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5X77_09370	COG0250	Participates in transcription elongation, termination and antitermination
K5X77_09375	COG3123	guanosine phosphorylase activity
K5X77_09380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5X77_09400	COG1396	sequence-specific DNA binding
K5X77_09405	COG1760	l-serine dehydratase
K5X77_09410	COG1760	l-serine dehydratase
K5X77_09415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5X77_09420	COG0081	regulation of translation
K5X77_09425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5X77_09430	COG0222	ribosome binding
K5X77_09440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5X77_09445	COG0477	Major facilitator Superfamily
K5X77_09450	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K5X77_09455	COG1242	4 iron, 4 sulfur cluster binding
K5X77_09460	COG0671	phosphoesterase, PA-phosphatase related
K5X77_09475	COG1388	LysM domain
K5X77_09475	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5X77_09480	COG0495	leucyl-tRNA aminoacylation
K5X77_09485	COG1671	Belongs to the UPF0178 family
K5X77_09490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5X77_09530	COG3764	Sortase (surface protein transpeptidase)
K5X77_09540	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5X77_09545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5X77_09555	COG0736	holo-[acyl-carrier-protein] synthase activity
K5X77_09575	COG4443	Transcriptional Coactivator p15 (PC4)
K5X77_09580	COG1561	YicC-like family, N-terminal region
K5X77_09585	COG0194	GDP metabolic process
K5X77_09595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5X77_09600	COG0242	peptide deformylase activity
K5X77_09605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5X77_09610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5X77_09610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5X77_09615	COG0631	protein serine/threonine phosphatase activity
K5X77_09620	COG2815	serine threonine protein kinase
K5X77_09620	COG0515	serine threonine protein kinase
K5X77_09625	COG0785	Cytochrome C biogenesis protein
K5X77_09635	COG1162	GTPase activity
K5X77_09640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5X77_09645	COG1564	THIamine pyrophosphokinase
K5X77_09650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5X77_09665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5X77_09670	COG0416	fatty acid biosynthetic process
K5X77_09675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5X77_09685	COG4608	Belongs to the ABC transporter superfamily
K5X77_09690	COG0601	transmembrane transport
K5X77_09710	COG0571	ribonuclease III activity
K5X77_09715	COG1196	nuclear chromosome segregation
K5X77_09720	COG0561	phosphatase activity
K5X77_09725	COG0552	protein localization to endoplasmic reticulum
K5X77_09730	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5X77_09730	COG2918	glutathione biosynthetic process
K5X77_09735	COG3853	Toxic anion resistance protein (TelA)
K5X77_09755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5X77_09760	COG1335	isochorismatase
K5X77_09765	COG3594	Acyltransferase
K5X77_09770	COG1104	cysteine desulfurase activity
K5X77_09780	COG0482	sulfurtransferase activity
K5X77_09785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5X77_09785	COG2207	Transcriptional regulator
K5X77_09790	COG1132	(ABC) transporter
K5X77_09795	COG1132	(ABC) transporter
K5X77_09800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5X77_09810	COG0719	Fe-S assembly protein
K5X77_09815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5X77_09820	COG0822	iron-sulfur transferase activity
K5X77_09860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K5X77_09890	COG1192	Involved in chromosome partitioning
K5X77_09955	COG0484	heat shock protein binding
K5X77_10005	COG0741	lytic transglycosylase activity
K5X77_10005	COG0791	NLP P60 protein
K5X77_10085	COG1484	DNA-dependent DNA replication