locus-tag	class	description
E4Z98_00050	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E4Z98_00055	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E4Z98_00060	ENOG4108UUM	single-stranded DNA-binding protein
E4Z98_00065	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E4Z98_00070	ENOG4108RS6	transposase
E4Z98_00080	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4Z98_00085	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E4Z98_00090	ENOG410848D	S4 domain protein YaaA
E4Z98_00095	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E4Z98_00100	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E4Z98_00110	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E4Z98_00115	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E4Z98_00125	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E4Z98_00130	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E4Z98_00135	ENOG4105DQR	SNARE associated Golgi
E4Z98_00140	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
E4Z98_00145	ENOG4107QJE	Chromosome Partitioning Protein
E4Z98_00150	ENOG4105FA0	parb-like partition protein
E4Z98_00155	ENOG4105VDK	protein, conserved in bacteria
E4Z98_00160	ENOG4105C3G	gtp-binding protein
E4Z98_00170	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4Z98_00175	ENOG4105DCF	alanine dehydrogenase
E4Z98_00180	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E4Z98_00265	ENOG4105KT7	mgtC SapB transporter
E4Z98_00275	ENOG41069ER	domain protein
E4Z98_00290	ENOG4105C72	UPF0176 protein
E4Z98_00295	ENOG4105EEM	helicase
E4Z98_00300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E4Z98_00305	ENOG4105BZU	Histidine kinase
E4Z98_00325	ENOG4105Q2H	domain protein
E4Z98_00330	ENOG4105KNA	-acetyltransferase
E4Z98_00340	ENOG4105DER	m42 family
E4Z98_00355	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
E4Z98_00360	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E4Z98_00365	ENOG4105VPX	protein, conserved in bacteria
E4Z98_00380	ENOG4105JAB	phenazine biosynthesis protein, phzf family
E4Z98_00385	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E4Z98_00395	ENOG4105CTP	PilT protein domain protein
E4Z98_00400	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E4Z98_00405	ENOG4105D7W	serine acetyltransferase
E4Z98_00410	ENOG4105C8N	cysteinyl-tRNA synthetase
E4Z98_00415	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E4Z98_00420	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E4Z98_00425	ENOG4105M0M	Tetracycline resistance protein
E4Z98_00445	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
E4Z98_00455	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
E4Z98_00460	ENOG4105DBI	uridine monophosphokinase
E4Z98_00490	ENOG4108I7Y	domain protein
E4Z98_00500	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
E4Z98_00510	ENOG4105CGH	5'-nucleotidase
E4Z98_00515	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
E4Z98_00530	ENOG4105D5T	phosphonate abc transporter
E4Z98_00545	ENOG4105VC4	domain protein
E4Z98_00550	ENOG41060K3	Methyltransferase
E4Z98_00555	ENOG4105F6E	Acyl-transferase
E4Z98_00570	ENOG4105C0H	protease
E4Z98_00575	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E4Z98_00585	ENOG4105EJQ	L-serine dehydratase
E4Z98_00595	ENOG4105SFS	phosphoesterase RecJ domain protein
E4Z98_00600	ENOG4105C5H	ABC transporter
E4Z98_00605	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
E4Z98_00635	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
E4Z98_00655	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4Z98_00660	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4Z98_00670	ENOG4108JQ7	(ABC) transporter
E4Z98_00680	ENOG4105EP9	oxidoreductase
E4Z98_00695	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E4Z98_00700	ENOG4105C5Y	PTS System
E4Z98_00705	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E4Z98_00710	ENOG4106KNT	transcriptional regulator
E4Z98_00720	ENOG4107RFY	SbcCD D subunit
E4Z98_00725	ENOG4105EYH	Exonuclease
E4Z98_00730	ENOG4105C0D	helicase
E4Z98_00735	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
E4Z98_00740	ENOG4105BZ1	(ABC) transporter
E4Z98_00760	ENOG4105C7N	Xanthine uracil vitamin C permease
E4Z98_00785	ENOG4108ZCF	integral membrane protein
E4Z98_00795	ENOG4105CHR	reductase
E4Z98_00805	ENOG4105FS7	Transcriptional regulator
E4Z98_00810	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E4Z98_00815	ENOG4108IGT	Dipeptidase
E4Z98_00825	ENOG4108X4Q	Hydrolase
E4Z98_00835	ENOG4105CID	antiterminator
E4Z98_00840	ENOG4105C5Y	PTS System
E4Z98_00845	ENOG4105CS2	ec 3.2.1.21
E4Z98_00850	ENOG4108IUX	(ABC) transporter
E4Z98_00855	ENOG4105RHA	ABC transporter, permease
E4Z98_00870	ENOG4105DUX	Transporter
E4Z98_00875	ENOG4105X71	Membrane
E4Z98_00885	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
E4Z98_00890	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E4Z98_00895	ENOG4107RWR	Sodium hydrogen exchanger
E4Z98_00905	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
E4Z98_00920	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
E4Z98_00940	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E4Z98_00945	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E4Z98_00950	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
E4Z98_00955	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E4Z98_00960	ENOG4105VIE	preprotein translocase, subunit YajC
E4Z98_00970	ENOG4108EKI	Dehydrogenase
E4Z98_00975	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
E4Z98_01020	ENOG4108JQ7	(ABC) transporter
E4Z98_01025	ENOG4105C3U	ABC transporter
E4Z98_01030	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4Z98_01045	ENOG4105MIX	Adenylate cyclase
E4Z98_01055	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E4Z98_01060	ENOG4105EMS	pseudouridine synthase
E4Z98_01065	ENOG4105CJW	magnesium transporter
E4Z98_01075	ENOG4106N3A	copper homeostasis protein cutc
E4Z98_01085	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
E4Z98_01090	ENOG4105DAP	Nicotinate phosphoribosyltransferase
E4Z98_01100	ENOG4107T7U	Sulfatase
E4Z98_01105	ENOG4105BZU	Histidine kinase
E4Z98_01135	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E4Z98_01140	ENOG4108JA2	transcriptioN-repair coupling factor
E4Z98_01150	ENOG41082I2	s4 domain protein
E4Z98_01160	ENOG41060GV	RNA binding s1 domain protein
E4Z98_01165	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
E4Z98_01170	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
E4Z98_01180	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
E4Z98_01185	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E4Z98_01190	ENOG4105CRK	lysyL-tRNA synthetase
E4Z98_01280	ENOG41080Y5	BioY family
E4Z98_01285	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
E4Z98_01290	ENOG4105C83	adenylosuccinate lyase
E4Z98_01295	ENOG4105G5W	regulator Fur family
E4Z98_01445	ENOG4105QIV	RNA polymerase
E4Z98_01450	ENOG4105W42	Veg protein
E4Z98_01455	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
E4Z98_01460	ENOG4105HDK	L-asparaginase
E4Z98_01475	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
E4Z98_01480	ENOG4105C3J	Cysteine desulfurase
E4Z98_01485	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
E4Z98_01490	ENOG4108YWR	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
E4Z98_01530	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
E4Z98_01535	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E4Z98_01540	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E4Z98_01545	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
E4Z98_01560	ENOG4105W5Q	DNA repair protein (RadC
E4Z98_01570	ENOG4108RS6	transposase
E4Z98_01575	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
E4Z98_01585	ENOG4107PP3	Acetylornithine deacetylase
E4Z98_01590	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
E4Z98_01595	ENOG4105FDK	ABC transporter
E4Z98_01605	ENOG4105DFT	pur operon repressor
E4Z98_01610	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E4Z98_01615	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E4Z98_01625	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
E4Z98_01640	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
E4Z98_01650	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
E4Z98_01685	ENOG410667J	hydrolase
E4Z98_01690	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E4Z98_01695	ENOG4105BZU	Histidine kinase
E4Z98_01700	ENOG4105WBI	UPF0223 protein
E4Z98_01705	ENOG4105ECY	inositol monophosphatase
E4Z98_01710	ENOG4105CI3	gtp-binding protein typa
E4Z98_01715	ENOG4105D2N	Aldolase
E4Z98_01720	ENOG4105CS2	ec 3.2.1.21
E4Z98_01770	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E4Z98_01775	ENOG4105F8V	Hydrolase, tatD family
E4Z98_01780	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
E4Z98_01785	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E4Z98_01790	ENOG4105C1G	acyl-Coa dehydrogenase
E4Z98_01795	ENOG4105DZ2	Transcriptional regulator
E4Z98_01800	ENOG4105CHU	acetyl-coa acetyltransferase
E4Z98_01805	ENOG4105C1G	acyl-Coa dehydrogenase
E4Z98_01810	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E4Z98_01815	ENOG4105E39	Enoyl-CoA hydratase
E4Z98_01820	ENOG4105CYC	Transferase
E4Z98_01825	ENOG4105C8F	Beta-lactamase domain protein
E4Z98_01830	ENOG4108IJ9	(ABC) transporter
E4Z98_01840	ENOG4107SC7	Inner membrane transporter yjeM
E4Z98_01850	ENOG4105CI1	PTS System
E4Z98_01860	ENOG4107URF	beta-phospho-glucomutase
E4Z98_01865	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E4Z98_01870	ENOG4105ETE	Transcriptional regulator (LacI family
E4Z98_01880	ENOG4105CG3	alpha amylase, catalytic region
E4Z98_01885	ENOG4108IUK	alpha amylase, catalytic
E4Z98_01895	ENOG4105D56	permease protein
E4Z98_01900	ENOG4105EG2	ABC transporter, permease
E4Z98_01925	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
E4Z98_01930	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
E4Z98_01945	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
E4Z98_01955	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
E4Z98_01970	ENOG4105DR4	Methyltransferase
E4Z98_01975	ENOG4108Z66	YbaK ebsC protein
E4Z98_01980	ENOG4105CCI	Myosin-Cross-Reactive Antigen
E4Z98_01995	ENOG4105CBX	hi0933 family
E4Z98_02000	ENOG4107R37	Glutamate dehydrogenase
E4Z98_02005	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
E4Z98_02010	ENOG4105EHG	Permease protein
E4Z98_02015	ENOG4105E0A	ABC, transporter
E4Z98_02025	ENOG4105CEP	NADH dehydrogenase
E4Z98_02035	ENOG4108RYK	Nad-dependent epimerase dehydratase
E4Z98_02055	ENOG4105CH2	amidohydrolase
E4Z98_02075	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E4Z98_02080	ENOG4105CS9	pantothenic acid kinase
E4Z98_02085	ENOG4108S4H	thioesterase Superfamily protein
E4Z98_02095	ENOG4107Y49	methyltransferase
E4Z98_02100	ENOG4105CE9	30S ribosomal protein S2
E4Z98_02105	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E4Z98_02110	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E4Z98_02115	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E4Z98_02170	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E4Z98_02175	ENOG4105KNE	Phosphatidate cytidylyltransferase
E4Z98_02180	ENOG4105DZP	Membrane-associated zinc metalloprotease
E4Z98_02185	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E4Z98_02195	ENOG4105DBV	ornithine carbamoyltransferase
E4Z98_02200	ENOG4105C5B	carbamate kinase
E4Z98_02205	ENOG4105IJS	Transcriptional regulator
E4Z98_02210	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
E4Z98_02215	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
E4Z98_02225	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
E4Z98_02235	ENOG4105C4R	Atp-dependent dna helicase
E4Z98_02240	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E4Z98_02250	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E4Z98_02255	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E4Z98_02260	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E4Z98_02265	ENOG4105CBD	Diacylglycerol kinase
E4Z98_02270	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E4Z98_02280	ENOG4108WQ8	UPF0637 protein
E4Z98_02295	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E4Z98_02300	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
E4Z98_02330	ENOG4105DTQ	mandelate racemase muconate lactonizing
E4Z98_02335	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
E4Z98_02340	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
E4Z98_02345	ENOG4105E4F	Isochorismate synthase
E4Z98_02350	ENOG4105CEY	Amp-dependent synthetase and ligase
E4Z98_02355	ENOG4108IPT	Naphthoate synthase
E4Z98_02375	ENOG4107R7I	amino acid
E4Z98_02380	ENOG4108RS6	transposase
E4Z98_02385	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E4Z98_02395	ENOG4107R7I	amino acid
E4Z98_02400	ENOG4105C22	threonyL-tRNA synthetase
E4Z98_02405	ENOG4107RF6	penicillin-binding protein
E4Z98_02410	ENOG4105WDJ	50S ribosomal protein L33
E4Z98_02415	ENOG4105VTR	Integrase
E4Z98_02450	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E4Z98_02665	ENOG4105WWX	n-acetylmuramoyl-l-alanine amidase
E4Z98_02675	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E4Z98_02680	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
E4Z98_02685	ENOG410667J	hydrolase
E4Z98_02690	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E4Z98_02720	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4Z98_02725	ENOG4108EQA	pts system
E4Z98_02735	ENOG4105ETZ	PTS System
E4Z98_02740	ENOG4105F3R	pts system mannose fructose sorbose family iid
E4Z98_02750	ENOG4105DC7	peptidase M24
E4Z98_02755	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E4Z98_02760	ENOG4108ZSR	alkaline shock protein
E4Z98_02765	ENOG4105M7K	Involved in the transcription termination process (By similarity)
E4Z98_02770	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E4Z98_02775	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E4Z98_02785	ENOG4105DX0	Hemolysin A
E4Z98_02790	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E4Z98_02795	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E4Z98_02800	ENOG4105N80	Ferric uptake regulator, Fur family
E4Z98_02805	ENOG4105VCC	30S ribosomal protein S21
E4Z98_02810	ENOG4105KTH	gatB Yqey
E4Z98_02825	ENOG4105EQ0	Major Facilitator superfamily
E4Z98_02840	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E4Z98_02850	ENOG4105K46	50S ribosomal protein l27
E4Z98_02855	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E4Z98_02870	ENOG4105DKQ	ROK family
E4Z98_02875	ENOG4107YZP	Rhodanese domain protein
E4Z98_02885	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4Z98_02890	ENOG4105KRI	phosphocarrier protein (HPr
E4Z98_02895	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
E4Z98_02900	ENOG4105BZF	Glycosyl transferase (Group 1
E4Z98_02905	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
E4Z98_02920	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E4Z98_02925	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E4Z98_02930	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E4Z98_02935	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
E4Z98_02940	ENOG4105CQW	ribosome biogenesis GTPase YqeH
E4Z98_02945	ENOG410812S	Rna-binding protein
E4Z98_02950	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E4Z98_02955	ENOG4108WF2	Metal Dependent Phosphohydrolase
E4Z98_02965	ENOG4108D32	Methyltransferase
E4Z98_02975	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
E4Z98_02985	ENOG4105DWF	phosphomethylpyrimidine kinase
E4Z98_02990	ENOG4105DWF	phosphomethylpyrimidine kinase
E4Z98_03005	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E4Z98_03010	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E4Z98_03015	ENOG4105EA8	2-Nitropropane dioxygenase
E4Z98_03020	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E4Z98_03025	ENOG4105CHR	reductase
E4Z98_03030	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4Z98_03040	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E4Z98_03045	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E4Z98_03050	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E4Z98_03055	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
E4Z98_03060	ENOG4105RNB	
E4Z98_03075	ENOG4107VFR	oxidoreductase
E4Z98_03085	ENOG4105C5F	glutamine synthetase
E4Z98_03090	ENOG4105C59	p-type ATPase
E4Z98_03100	ENOG4105C1J	atp-dependent rna helicase
E4Z98_03105	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E4Z98_03110	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
E4Z98_03120	ENOG4105ETD	TRANSCRIPTIONal
E4Z98_03125	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
E4Z98_03130	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
E4Z98_03140	ENOG41072GX	Peptidase M22 Glycoprotease
E4Z98_03145	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
E4Z98_03155	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4Z98_03160	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4Z98_03165	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4Z98_03190	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E4Z98_03205	ENOG4105ENE	Histidine kinase
E4Z98_03210	ENOG4105WH1	Two component transcriptional regulator luxr family
E4Z98_03215	ENOG4107ZYR	domain protein
E4Z98_03220	ENOG4105W8X	HesB YadR YfhF-family protein
E4Z98_03230	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E4Z98_03235	ENOG4105ZPI	UPF0358 protein
E4Z98_03240	ENOG4105CNI	cell division protein FtsW
E4Z98_03245	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
E4Z98_03260	ENOG4105WUC	UPF0298 protein
E4Z98_03265	ENOG4106H78	methyltransferase
E4Z98_03270	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E4Z98_03275	ENOG41063PX	domain protein
E4Z98_03280	ENOG4105C7H	Helicase, RecD TraA family
E4Z98_03290	ENOG4105DFU	Cell wall formation (By similarity)
E4Z98_03295	ENOG4105HFZ	Membrane
E4Z98_03305	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E4Z98_03310	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
E4Z98_03315	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E4Z98_03335	ENOG41067VY	50S ribosomal protein L32
E4Z98_03340	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
E4Z98_03345	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E4Z98_03350	ENOG4105GR3	Histidine kinase
E4Z98_03360	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
E4Z98_03365	ENOG410855V	Acylphosphatase
E4Z98_03370	ENOG4108RWN	rrna methyltransferase
E4Z98_03380	ENOG4105KVH	Transcriptional regulator
E4Z98_03385	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E4Z98_03390	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E4Z98_03400	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E4Z98_03405	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
E4Z98_03410	ENOG4105M59	Phosphodiesterase, mj0936 family
E4Z98_03425	ENOG41082BM	Transcriptional regulator, arsr family
E4Z98_03440	ENOG41082T9	Membrane
E4Z98_03445	ENOG4105F23	Fibronectin-binding protein
E4Z98_03460	ENOG4105C37	(CBS) domain
E4Z98_03475	ENOG4105CS2	ec 3.2.1.21
E4Z98_03490	ENOG410841Q	phosphoesterase PA-phosphatase related protein
E4Z98_03500	ENOG41080TC	multidrug resistance protein
E4Z98_03510	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
E4Z98_03525	ENOG4105E5D	amino acid
E4Z98_03530	ENOG4105CI1	PTS System
E4Z98_03550	ENOG4105C6K	Malic enzyme
E4Z98_03555	ENOG4105C9Q	fumarate hydratase class II
E4Z98_03560	ENOG4108TGC	Acyltransferase
E4Z98_03575	ENOG4105CDA	abc transporter atp-binding protein
E4Z98_03580	ENOG4105E5Q	amino acid AbC transporter
E4Z98_03590	ENOG4105EJV	Membrane
E4Z98_03600	ENOG410749K	Uncharacterized protein conserved in bacteria (DUF2179)
E4Z98_03605	ENOG4107104	thymidine kinase
E4Z98_03610	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E4Z98_03615	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E4Z98_03620	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4Z98_03625	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E4Z98_03630	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
E4Z98_03640	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E4Z98_03650	ENOG4105CAQ	asparagine synthetase
E4Z98_03655	ENOG4105C8I	hydrolase, family 38
E4Z98_03660	ENOG4105CK1	PTS System
E4Z98_03675	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
E4Z98_03680	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
E4Z98_03710	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E4Z98_03720	ENOG4108STX	response regulator
E4Z98_03725	ENOG4105US7	Histidine kinase
E4Z98_03730	ENOG4105E2X	shikimate dehydrogenase
E4Z98_03735	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
E4Z98_03745	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
E4Z98_03750	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
E4Z98_03755	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
E4Z98_03765	ENOG4105EPR	degv family
E4Z98_03775	ENOG4105C0B	DNA polymerase III (alpha subunit)
E4Z98_03780	ENOG4105CTQ	phosphohexokinase
E4Z98_03800	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
E4Z98_03805	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4Z98_03810	ENOG4105C79	DNA protecting protein DprA
E4Z98_03815	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E4Z98_03820	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
E4Z98_03825	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4Z98_03830	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
E4Z98_03835	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E4Z98_03845	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E4Z98_03850	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E4Z98_03855	ENOG4105C6T	cysteine synthase
E4Z98_03870	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E4Z98_03875	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E4Z98_03880	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E4Z98_03885	ENOG4105CHW	UPF0052 protein
E4Z98_03890	ENOG4105CIE	May be required for sporulation (By similarity)
E4Z98_03900	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E4Z98_03915	ENOG4105XZU	Preprotein translocase, subunit SecG
E4Z98_03925	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
E4Z98_03930	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E4Z98_03935	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
E4Z98_03950	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4Z98_03965	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E4Z98_03980	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E4Z98_03990	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E4Z98_03995	ENOG4105EVU	fructokinase
E4Z98_04020	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
E4Z98_04025	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E4Z98_04030	ENOG4107XGZ	Hydrolase
E4Z98_04035	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E4Z98_04040	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E4Z98_04050	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
E4Z98_04070	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E4Z98_04075	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
E4Z98_04080	ENOG4105CDY	transcriptional regulatory protein
E4Z98_04100	ENOG4107BMA	Transglycosylase associated protein
E4Z98_04105	ENOG4108TVJ	Nitroreductase
E4Z98_04110	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E4Z98_04125	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
E4Z98_04130	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
E4Z98_04135	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E4Z98_04140	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E4Z98_04150	ENOG4105FH5	Membrane
E4Z98_04155	ENOG4105YA8	Transcriptional regulator
E4Z98_04160	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4Z98_04165	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4Z98_04180	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
E4Z98_04185	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4Z98_04190	ENOG4105K5M	30s ribosomal protein S16
E4Z98_04195	ENOG410645S	MarR family Transcriptional regulator
E4Z98_04200	ENOG4105CGZ	zinc metallopeptidase
E4Z98_04205	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E4Z98_04210	ENOG4105C19	ABC transporter
E4Z98_04220	ENOG4105ZMH	deoxynucleoside kinase
E4Z98_04225	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E4Z98_04230	ENOG4105C6N	Formate acetyltransferase
E4Z98_04235	ENOG4105F1A	Pyruvate formate-lyase
E4Z98_04240	ENOG4108IJ0	Aspartate ammonia-lyase
E4Z98_04245	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
E4Z98_04255	ENOG4105F1K	Glutamine amidotransferase
E4Z98_04260	ENOG4105DMS	mur ligase
E4Z98_04275	ENOG4105NA0	Transcriptional regulator
E4Z98_04290	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E4Z98_04295	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E4Z98_04300	ENOG4105BZ4	penicillin-binding protein
E4Z98_04305	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
E4Z98_04310	ENOG4108UKS	UPF0398 protein
E4Z98_04315	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
E4Z98_04325	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
E4Z98_04330	ENOG4105CTD	carboxy-peptidase
E4Z98_04335	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
E4Z98_04340	ENOG4105EPR	degv family
E4Z98_04350	ENOG4105VND	Ribonuclease
E4Z98_04360	ENOG4105VEQ	Cold shock protein
E4Z98_04375	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E4Z98_04380	ENOG4105C34	Pseudouridine synthase
E4Z98_04385	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
E4Z98_04395	ENOG4105CXT	aspartate transcarbamylase
E4Z98_04400	ENOG4105CD3	dihydroorotase
E4Z98_04405	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E4Z98_04410	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E4Z98_04415	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
E4Z98_04425	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E4Z98_04430	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E4Z98_04435	ENOG4108UHE	carbonic anhydrase
E4Z98_04440	ENOG4105CVA	phosphate
E4Z98_04445	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E4Z98_04455	ENOG41069HH	4-oxalocrotonate tautomerase
E4Z98_04460	ENOG4107RB4	Cytidine monophosphate kinase
E4Z98_04465	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
E4Z98_04470	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E4Z98_04500	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
E4Z98_04510	ENOG4107AYK	membrAne
E4Z98_04515	ENOG4105VG1	fes assembly suf system protein
E4Z98_04535	ENOG4105CS2	ec 3.2.1.21
E4Z98_04540	ENOG4105DVT	helicase
E4Z98_04550	ENOG4105CHM	Aminotransferase
E4Z98_04555	ENOG4105C5S	asparaginyl-tRNA synthetase
E4Z98_04560	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
E4Z98_04565	ENOG4105DVE	abc transporter atp-binding protein
E4Z98_04575	ENOG4107WD8	ABC transporter, permease
E4Z98_04590	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E4Z98_04595	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4Z98_04600	ENOG4105FF2	Type I DHQase
E4Z98_04610	ENOG4105EGD	dinuclear metal center protein, YbgI family
E4Z98_04615	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
E4Z98_04630	ENOG4105BZ4	penicillin-binding protein
E4Z98_04635	ENOG4105U0R	haloacid dehalogenase-like hydrolase
E4Z98_04645	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
E4Z98_04650	ENOG4105VXM	UPF0154 protein
E4Z98_04655	ENOG4105BZ1	(ABC) transporter
E4Z98_04660	ENOG4105BZ1	(ABC) transporter
E4Z98_04665	ENOG4105EQD	regulatoR
E4Z98_04670	ENOG4105C2F	Histidine kinase
E4Z98_04675	ENOG4105EMA	Periplasmic binding protein LacI transcriptional regulator
E4Z98_04680	ENOG4105EMA	Periplasmic binding protein LacI transcriptional regulator
E4Z98_04685	ENOG4105C2J	ABC transporter
E4Z98_04690	ENOG4108HWV	)-transporter
E4Z98_04695	ENOG4105UQX	Mate efflux family protein
E4Z98_04700	ENOG4105C3M	thioredoxin reductase
E4Z98_04705	ENOG4105CDE	UPF0348 protein
E4Z98_04720	ENOG4105K5M	30s ribosomal protein S16
E4Z98_04725	ENOG4105VB6	UPF0109 protein
E4Z98_04745	ENOG4108RS6	transposase
E4Z98_04755	ENOG4105CS2	ec 3.2.1.21
E4Z98_04760	ENOG4108TZY	GntR Family Transcriptional Regulator
E4Z98_04765	ENOG4107RCM	Releases the N-terminal proline from various substrates (By similarity)
E4Z98_04795	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
E4Z98_04800	ENOG41090MY	MarR family Transcriptional regulator
E4Z98_04810	ENOG4105DA2	glyoxalase bleomycin resistance protein dioxygenase
E4Z98_04815	ENOG4107XC4	flavin reductase domain protein, FMN-binding
E4Z98_04825	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E4Z98_04835	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4Z98_04840	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
E4Z98_04845	ENOG4108IXY	short-chain dehydrogenase reductase
E4Z98_04855	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E4Z98_04860	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
E4Z98_04865	ENOG41065S2	pneumococcal vaccine antigen
E4Z98_04875	ENOG4105CSM	endonuclease III
E4Z98_04890	ENOG4105C26	Dehydrogenase
E4Z98_04900	ENOG4108IPW	abc transporter atp-binding protein
E4Z98_04905	ENOG4105CM4	permease protein
E4Z98_04910	ENOG4105DHS	permease protein
E4Z98_04915	ENOG4105EXC	Acyl-transferase
E4Z98_04925	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4Z98_04935	ENOG41090WU	lipolytic protein G-D-S-L family
E4Z98_04940	ENOG4108RCR	degv family
E4Z98_04945	ENOG4108UT2	hemolysin iii
E4Z98_04960	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E4Z98_04965	ENOG4108Z5K	methylglyoxal synthase
E4Z98_04970	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
E4Z98_04975	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
E4Z98_04980	ENOG4105C5H	ABC transporter
E4Z98_04995	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E4Z98_05000	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
E4Z98_05005	ENOG4108SXZ	UPF0302 protein
E4Z98_05015	ENOG4105K70	DNA-binding protein
E4Z98_05020	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E4Z98_05025	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E4Z98_05030	ENOG4105CAT	Cytidine monophosphate kinase
E4Z98_05040	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4Z98_05055	ENOG4108SAX	Membrane
E4Z98_05060	ENOG4105FE9	pseudouridine synthase
E4Z98_05065	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
E4Z98_05070	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
E4Z98_05075	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4Z98_05080	ENOG4105I3K	Ferric uptake regulator, Fur family
E4Z98_05090	ENOG4105QNR	S1 RNA binding domain protein
E4Z98_05095	ENOG4105C7N	Xanthine uracil vitamin C permease
E4Z98_05100	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
E4Z98_05145	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
E4Z98_05240	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4Z98_05250	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E4Z98_05255	ENOG4105CP7	Triose-phosphate isomerase
E4Z98_05260	ENOG4105BZA	Phosphoglycerate kinase
E4Z98_05265	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E4Z98_05275	ENOG4107R4J	Chloride channel
E4Z98_05280	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4Z98_05310	ENOG4105D9R	oxidoreductase
E4Z98_05315	ENOG4105C2X	Arabinose 5-phosphate isomerase
E4Z98_05320	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4Z98_05330	ENOG41062JF	Transcriptional regulator
E4Z98_05345	ENOG4105ETE	Transcriptional regulator (LacI family
E4Z98_05350	ENOG4105DSE	periplasmic solute binding protein
E4Z98_05355	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E4Z98_05360	ENOG4105CFG	Acts as a chaperone (By similarity)
E4Z98_05365	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4Z98_05370	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
E4Z98_05375	ENOG4105CSA	Coproporphyrinogen iii oxidase
E4Z98_05380	ENOG4105DTN	riboflavin biosynthesis protein ribF
E4Z98_05385	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E4Z98_05395	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E4Z98_05410	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
E4Z98_05415	ENOG4105CHV	Transcription elongation factor NusA
E4Z98_05420	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E4Z98_05425	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E4Z98_05430	ENOG4105TMB	Formate nitrite transporter
E4Z98_05435	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
E4Z98_05445	ENOG41081UC	Inherit from COG: Competence protein
E4Z98_05465	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
E4Z98_05470	ENOG4105FDP	GntR family transcriptional regulator
E4Z98_05480	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E4Z98_05495	ENOG4105D8X	mechanosensitive ion channel
E4Z98_05505	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
E4Z98_05510	ENOG4105C12	Phosphoribosylglycinamide synthetase
E4Z98_05520	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E4Z98_05525	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E4Z98_05530	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E4Z98_05535	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
E4Z98_05540	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
E4Z98_05545	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
E4Z98_05550	ENOG4105C8V	SAICAR synthetase
E4Z98_05555	ENOG4105C83	adenylosuccinate lyase
E4Z98_05560	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E4Z98_05565	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E4Z98_05570	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
E4Z98_05575	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E4Z98_05580	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E4Z98_05585	ENOG4105E2Z	phosphate ABC transporter (Permease
E4Z98_05590	ENOG4105C8U	phosphate abc transporter
E4Z98_05595	ENOG4105CVA	phosphate
E4Z98_05600	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
E4Z98_05605	ENOG4105CAK	Cell division ATP-binding protein ftsE
E4Z98_05615	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E4Z98_05635	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E4Z98_05640	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4Z98_05655	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E4Z98_05660	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
E4Z98_05665	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
E4Z98_05670	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
E4Z98_05680	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E4Z98_05690	ENOG4105C9A	Phoh family
E4Z98_05695	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
E4Z98_05700	ENOG4107SUZ	Sodium/hydrogen exchanger family
E4Z98_05705	ENOG4105CHU	acetyl-coa acetyltransferase
E4Z98_05710	ENOG4105CNU	cell division protein FtsK
E4Z98_05720	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4Z98_05730	ENOG4105D01	(LipO)protein
E4Z98_05735	ENOG4108UMI	ABC transporter, permease
E4Z98_05740	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E4Z98_05745	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E4Z98_05750	ENOG41080E8	Transcriptional regulator, Spx MgsR family
E4Z98_05775	ENOG4105CPC	Aldo Keto reductase
E4Z98_05780	ENOG4105UQX	Mate efflux family protein
E4Z98_05800	ENOG4107BMA	Transglycosylase associated protein
E4Z98_05805	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
E4Z98_05815	ENOG4105DM4	PTS System
E4Z98_05820	ENOG4105DM4	PTS System
E4Z98_05825	ENOG4105DM4	PTS System
E4Z98_05840	ENOG410749K	Uncharacterized protein conserved in bacteria (DUF2179)
E4Z98_05850	ENOG4105E4P	ATPase (AAA
E4Z98_05875	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
E4Z98_05885	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
E4Z98_05890	ENOG4108626	Racemase
E4Z98_05900	ENOG4108M21	
E4Z98_05905	ENOG4106PKC	pyridoxal phosphate binding
E4Z98_05910	ENOG41080QX	K07048 phosphotriesterase-related protein
E4Z98_05915	ENOG4106M0N	transport system permease protein
E4Z98_05920	ENOG4105MUZ	Protein of unknown function DUF2620
E4Z98_05930	ENOG4105CS2	ec 3.2.1.21
E4Z98_05935	ENOG4105C5Y	PTS System
E4Z98_05940	ENOG4105CID	antiterminator
E4Z98_05945	ENOG4105DIW	FeS assembly protein SUFB
E4Z98_05950	ENOG4108UNV	SUF system FeS assembly protein, NifU family
E4Z98_05955	ENOG4105C9B	Cysteine desulfurase
E4Z98_05960	ENOG4105JRK	feS assembly protein SufD
E4Z98_05975	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E4Z98_06050	ENOG4105C3J	Cysteine desulfurase
E4Z98_06055	ENOG4107RVG	penicillin-binding protein
E4Z98_06060	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
E4Z98_06065	ENOG4105CNN	ABC, transporter
E4Z98_06075	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
E4Z98_06080	ENOG4108RVA	ribokinase
E4Z98_06085	ENOG4105ETE	Transcriptional regulator (LacI family
E4Z98_06095	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
E4Z98_06115	ENOG4105CDW	Resistance protein
E4Z98_06120	ENOG4105E4C	Lytic transglycosylase catalytic
E4Z98_06130	ENOG4105D9M	gamma-glutamylcysteine synthetase
E4Z98_06165	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4Z98_06170	ENOG4108JQ7	(ABC) transporter
E4Z98_06180	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E4Z98_06185	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E4Z98_06190	ENOG4105CB5	ATP-dependent DNA helicase recG
E4Z98_06195	ENOG4105DP4	dak2 domain fusion protein ylov
E4Z98_06205	ENOG4105VB9	50S ribosomal protein l28
E4Z98_06210	ENOG4105FJ0	thiamine
E4Z98_06215	ENOG4105DJV	ribulose-phosphate 3-epimerase
E4Z98_06220	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
E4Z98_06225	ENOG4105D9P	serine threonine protein kinase
E4Z98_06230	ENOG4108ZF3	Phosphatase
E4Z98_06235	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E4Z98_06240	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E4Z98_06245	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E4Z98_06250	ENOG4105C25	Primosomal protein n'
E4Z98_06260	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E4Z98_06265	ENOG4105DSJ	YicC domain protein
E4Z98_06270	ENOG4105VEM	Conserved domain protein
E4Z98_06285	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
E4Z98_06290	ENOG4105C1J	atp-dependent rna helicase
E4Z98_06295	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
E4Z98_06310	ENOG4108Z6X	(sortase) family
E4Z98_06355	ENOG4105C3F	Signal peptidase i
E4Z98_06360	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
E4Z98_06385	ENOG4105KJF	protein tyrosine phosphatase
E4Z98_06395	ENOG4105C8T	Leucyl-tRNA synthetase
E4Z98_06400	ENOG4107X35	defense response to bacterium
E4Z98_06415	ENOG410841Q	phosphoesterase PA-phosphatase related protein
E4Z98_06420	ENOG4105N5T	Radical SAM Protein
E4Z98_06430	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E4Z98_06440	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E4Z98_06450	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E4Z98_06455	ENOG4108VZM	50s ribosomal protein L10
E4Z98_06460	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E4Z98_06465	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E4Z98_06475	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E4Z98_06485	ENOG4107FTN	50S ribosomal protein L33
E4Z98_06495	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E4Z98_06500	ENOG4105MMF	Cell division protein DIVIVA
E4Z98_06505	ENOG4105DBK	s4 domain protein
E4Z98_06515	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
E4Z98_06520	ENOG4105DFA	alanine racemase domain protein
E4Z98_06530	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E4Z98_06535	ENOG4105U2C	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
E4Z98_06540	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E4Z98_06545	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E4Z98_06550	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E4Z98_06555	ENOG4105CJN	penicillin-binding protein
E4Z98_06565	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E4Z98_06570	ENOG4108V6E	Cell division protein mraZ
E4Z98_06625	ENOG4105CAY	ferredoxin--nadp reductase
E4Z98_06630	ENOG4108W5N	phosphatidylglycerophosphatase a
E4Z98_06640	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
E4Z98_06645	ENOG4105MMD	transcriptional regulator
E4Z98_06650	ENOG4107R8B	5'-nucleotidase
E4Z98_06655	ENOG4105M2Z	protein tyrosine serine phosphatase
E4Z98_06660	ENOG4105HUF	DNA protection during starvation protein
E4Z98_06665	ENOG4105K63	Thioredoxin
E4Z98_06670	ENOG4105C98	muts2 protein
E4Z98_06680	ENOG410687F	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
E4Z98_06685	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4Z98_06745	ENOG4105VPH	UPF0473 protein
E4Z98_06750	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E4Z98_06755	ENOG4105VBH	UPF0297 protein
E4Z98_06760	ENOG4108VDD	TRNA binding domain protein
E4Z98_06765	ENOG4107YZX	Universal stress protein
E4Z98_06775	ENOG4105CN9	Peptidase m42 family protein
E4Z98_06785	ENOG4105D01	(LipO)protein
E4Z98_06790	ENOG4108UMI	ABC transporter, permease
E4Z98_06795	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E4Z98_06800	ENOG4108JJ8	(ABC) transporter
E4Z98_06810	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E4Z98_06815	ENOG4108V15	phosphotransferase enzyme family
E4Z98_06830	ENOG4105K59	histidine triad (HIT) protein
E4Z98_06840	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
E4Z98_06845	ENOG4105EQI	Metal Dependent Phosphohydrolase
E4Z98_06850	ENOG4106D4I	domain protein
E4Z98_06860	ENOG4105WZB	UPF0342 protein
E4Z98_06865	ENOG4105BZ4	penicillin-binding protein
E4Z98_06870	ENOG4108YBP	pseudouridine synthase
E4Z98_06875	ENOG4105C75	arginyL-tRNA synthetase
E4Z98_06890	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E4Z98_06900	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
E4Z98_06910	ENOG4105C8B	TIGR00159 family
E4Z98_06920	ENOG4108RYK	Nad-dependent epimerase dehydratase
E4Z98_06925	ENOG410906U	SprT-like
E4Z98_06945	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
E4Z98_06950	ENOG4105DYB	Isoaspartyl dipeptidase
E4Z98_06955	ENOG4105E89	ABC transporter
E4Z98_06960	ENOG4105CDA	abc transporter atp-binding protein
E4Z98_06965	ENOG4105E5Q	amino acid AbC transporter
E4Z98_06980	ENOG4105V75	Transcriptional regulator
E4Z98_06990	ENOG4105C7S	Dehydrogenase
E4Z98_07000	ENOG4107RUY	(E1 component), alpha subunit
E4Z98_07005	ENOG4107QM2	Aldo Keto reductase
E4Z98_07010	ENOG4105DRR	Transcriptional regulator, GntR family
E4Z98_07015	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E4Z98_07020	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
E4Z98_07025	ENOG4108VXD	carboxy-peptidase
E4Z98_07035	ENOG4108QEG	Membrane
E4Z98_07055	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
E4Z98_07065	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
E4Z98_07070	ENOG4105DCI	Phosphohydrolase
E4Z98_07075	ENOG410667J	hydrolase
E4Z98_07095	ENOG41063V3	Involved in initiation control of chromosome replication (By similarity)
E4Z98_07100	ENOG4105MA4	psp1 domain protein
E4Z98_07105	ENOG4105FA2	dna polymerase iii
E4Z98_07110	ENOG4105X0R	protein from nitrogen regulatory protein P-II
E4Z98_07115	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E4Z98_07120	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E4Z98_07125	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E4Z98_07130	ENOG4105C6E	dna polymerase iii
E4Z98_07155	ENOG4108Z6B	deaminase
E4Z98_07170	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
E4Z98_07175	ENOG4105MTF	NrdI protein
E4Z98_07180	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E4Z98_07185	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E4Z98_07195	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
E4Z98_07200	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
E4Z98_07205	ENOG4105C31	Tryptophanyl-tRNA synthetase
E4Z98_07220	ENOG4105DF9	Lipoate-protein, ligase
E4Z98_07225	ENOG4108RQ5	Beta-lactamase domain-containing protein
E4Z98_07230	ENOG4105CN9	Peptidase m42 family protein
E4Z98_07235	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
E4Z98_07240	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
E4Z98_07250	ENOG4105C02	permease
E4Z98_07255	ENOG41082BV	acetyltransferase
E4Z98_07260	ENOG4105CAQ	asparagine synthetase
E4Z98_07265	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
E4Z98_07270	ENOG4105BZ1	(ABC) transporter
E4Z98_07275	ENOG4105BZ1	(ABC) transporter
E4Z98_07300	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4Z98_07305	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
E4Z98_07315	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E4Z98_07320	ENOG4105EUB	pirin domain protein
E4Z98_07340	ENOG4108JJB	ABC transporter
E4Z98_07350	ENOG4105DUM	transcriptional regulator, lysR family
E4Z98_07360	ENOG4105F8D	glycoside hydrolase family 4
E4Z98_07375	ENOG4105C2W	permease
E4Z98_07380	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
E4Z98_07385	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E4Z98_07390	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E4Z98_07400	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E4Z98_07405	ENOG4105CH2	amidohydrolase
E4Z98_07415	ENOG4108YYH	Nadph-dependent fmn reductase
E4Z98_07420	ENOG4105S7A	ErfK ybiS ycfS ynhG family protein
E4Z98_07425	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
E4Z98_07430	ENOG4105KTU	Transcriptional regulator, arsr family
E4Z98_07525	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
E4Z98_07530	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E4Z98_07535	ENOG4105VJV	50s ribosomal protein L35
E4Z98_07540	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E4Z98_07545	ENOG4105DSE	periplasmic solute binding protein
E4Z98_07550	ENOG4105CC5	ABC transporter
E4Z98_07555	ENOG4105DIK	(ABC) transporter
E4Z98_07565	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
E4Z98_07570	ENOG4108URH	decarboxylase
E4Z98_07610	ENOG4108BRW	Activates expression of the rhaSR operon in response to L-rhamnose (By similarity)
E4Z98_07615	ENOG410830R	acetyltransferase
E4Z98_07625	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E4Z98_07630	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E4Z98_07640	ENOG4107YB9	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E4Z98_07650	ENOG41067MG	lrgb family
E4Z98_07655	ENOG4105VAW	lrga family
E4Z98_07660	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E4Z98_07675	ENOG4105CE4	GlcNAc 6-P deacetylase
E4Z98_07685	ENOG4105CHM	Aminotransferase
E4Z98_07695	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
E4Z98_07700	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
E4Z98_07705	ENOG4105CKV	Membrane
E4Z98_07715	ENOG410905X	membrane-flanked domain protein
E4Z98_07730	ENOG4107AYK	membrAne
E4Z98_07735	ENOG4105C9M	aspartyl-trna synthetase
E4Z98_07740	ENOG4105CUT	histidyl-tRNA synthetase
E4Z98_07745	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
E4Z98_07750	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
E4Z98_07755	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E4Z98_07760	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
E4Z98_07765	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E4Z98_07785	ENOG4105D1H	recombination factor protein RarA
E4Z98_07800	ENOG41080TK	Universal stress protein
E4Z98_07810	ENOG4107R7I	amino acid
E4Z98_07820	ENOG4105C5X	domain protein
E4Z98_07825	ENOG4107TXC	Transcriptional regulator
E4Z98_07830	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E4Z98_07835	ENOG4105VMP	Transcriptional regulator
E4Z98_07850	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
E4Z98_07855	ENOG4105BZ1	(ABC) transporter
E4Z98_07860	ENOG4105BZ1	(ABC) transporter
E4Z98_07870	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
E4Z98_07880	ENOG4105CHH	sulfate transporter
E4Z98_07885	ENOG4105EVI	UPF0374 protein
E4Z98_07895	ENOG4105CEN	a g-specific adenine glycosylase
E4Z98_07900	ENOG410902V	Modulates RecA activity (By similarity)
E4Z98_07935	ENOG4108KGH	TRANSCRIPTIONal
E4Z98_07945	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
E4Z98_07955	ENOG4105HTX	biosynthesis protein
E4Z98_07965	ENOG4105K4H	Nlp p60 protein
E4Z98_07980	ENOG4105CKK	Glycosyl transferase, family 2
E4Z98_07985	ENOG4105WH5	Teichoic acid glycosylation protein
E4Z98_07990	ENOG4107SJB	teichoic acid biosynthesis
E4Z98_08005	ENOG4107SJB	teichoic acid biosynthesis
E4Z98_08015	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
E4Z98_08020	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
E4Z98_08055	ENOG4107RZX	Teichoic acid biosynthesis protein
E4Z98_08060	ENOG4105EY8	ABC transporter
E4Z98_08065	ENOG4108KGH	TRANSCRIPTIONal
E4Z98_08070	ENOG4105ESV	Glycosyl transferase, family 4
E4Z98_08075	ENOG4107U9T	Pfam:Ribonuclease_BN
E4Z98_08085	ENOG4105NQC	Flavodoxin
E4Z98_08095	ENOG4105C88	aminopeptidase
E4Z98_08130	ENOG4105CK1	PTS System
E4Z98_08140	ENOG4105VZJ	PTS System
E4Z98_08165	ENOG4105CK1	PTS System
E4Z98_08170	ENOG4105VZJ	PTS System
E4Z98_08180	ENOG4105VZJ	PTS System
E4Z98_08185	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4Z98_08190	ENOG4105FDU	atp-dependent rna helicase
E4Z98_08195	ENOG4105EE0	oxidoreductase
E4Z98_08205	ENOG4107R0W	ABC transporter
E4Z98_08210	ENOG4105BZ1	(ABC) transporter
E4Z98_08215	ENOG4105BZ1	(ABC) transporter
E4Z98_08220	ENOG4106EHS	UPF0356 protein
E4Z98_08245	ENOG4105CXI	aluminum resistance protein
E4Z98_08250	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E4Z98_08255	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E4Z98_08260	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
E4Z98_08270	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E4Z98_08275	ENOG4105CEV	competence damage-inducible protein
E4Z98_08285	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E4Z98_08290	ENOG4107GRR	phosphate transport regulator
E4Z98_08295	ENOG4105CJ3	phosphate transporter
E4Z98_08300	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
E4Z98_08305	ENOG4107BJW	polysaccharide deacetylase
E4Z98_08330	ENOG4105TQK	DNA polymerase iii, delta' subunit
E4Z98_08335	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4Z98_08340	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
E4Z98_08345	ENOG4108UK2	deaminase
E4Z98_08350	ENOG4105KQC	Competence protein
E4Z98_08360	ENOG4108M1A	Chitin-binding protein
E4Z98_08370	ENOG4105DPH	UPF0371 protein
E4Z98_08375	ENOG4105CMR	udp-glucose 4-epimerase
E4Z98_08385	ENOG4108RS6	transposase
E4Z98_08395	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E4Z98_08400	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E4Z98_08405	ENOG4105CK1	PTS System
E4Z98_08420	ENOG4108RS6	transposase
E4Z98_08435	ENOG4105D4A	Cell wall formation (By similarity)
E4Z98_08440	ENOG4107YB6	acetyltransferase, (GNAT) family
E4Z98_08445	ENOG4105CGK	Exodeoxyribonuclease III
E4Z98_08455	ENOG4105DG6	mannose-6-phosphate isomerase
E4Z98_08470	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
E4Z98_08490	ENOG4108HW4	amino acid AbC transporter
E4Z98_08500	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
E4Z98_08505	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E4Z98_08530	ENOG4105E0X	reductase
E4Z98_08535	ENOG4108Z03	MAF-like protein
E4Z98_08540	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E4Z98_08545	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E4Z98_08555	ENOG4105D48	metallophosphoesterase
E4Z98_08560	ENOG4105CI1	PTS System
E4Z98_08570	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
E4Z98_08575	ENOG4107RUE	extracellular solute-binding protein family 1
E4Z98_08580	ENOG4105D38	putrescine abc transporter
E4Z98_08585	ENOG4105F38	ABC transporter, permease
E4Z98_08590	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4Z98_08605	ENOG4106F5Q	Membrane
E4Z98_08610	ENOG4105EMD	TRANSCRIPTIONal
E4Z98_08615	ENOG4105K8N	protein family UPF0079, ATPase
E4Z98_08620	ENOG4108IJ2	phosphate acetyltransferase
E4Z98_08625	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
E4Z98_08630	ENOG410667J	hydrolase
E4Z98_08640	ENOG4105EAH	synthase
E4Z98_08650	ENOG4108JJ8	(ABC) transporter
E4Z98_08655	ENOG4108JJ9	ABC, transporter
E4Z98_08660	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E4Z98_08665	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E4Z98_08670	ENOG4105DC8	reductase
E4Z98_08680	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4Z98_08685	ENOG4105KEX	transcriptional regulator, ctsr
E4Z98_08690	ENOG4105M6F	mutator MutT protein
E4Z98_08700	ENOG41069H0	dihydroorotase EC 3.5.2.3
E4Z98_08715	ENOG41069H0	dihydroorotase EC 3.5.2.3
E4Z98_08755	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E4Z98_08765	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
E4Z98_08770	ENOG4105DM4	PTS System
E4Z98_08775	ENOG4105DE4	1-phosphofructokinase
E4Z98_08780	ENOG4105E98	transcriptional regulator DeoR family
E4Z98_08800	ENOG4105DFH	Transport of potassium into the cell (By similarity)
E4Z98_08810	ENOG4105WWK	YheO domain protein
E4Z98_08820	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E4Z98_08830	ENOG4105C28	cystathionine
E4Z98_08845	ENOG4105DFH	Transport of potassium into the cell (By similarity)
E4Z98_08850	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E4Z98_08855	ENOG4108HHA	Transketolase
E4Z98_08860	ENOG4108UTZ	Dihydroxyacetone kinase
E4Z98_08865	ENOG410641M	
E4Z98_08875	ENOG4105VDH	Dihydroxyacetone kinase
E4Z98_08880	ENOG4108SH3	Triose-phosphate isomerase
E4Z98_08885	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
E4Z98_08890	ENOG4108YZG	isomerase
E4Z98_08895	ENOG4105E98	transcriptional regulator DeoR family
E4Z98_08900	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E4Z98_08905	ENOG4105CMT	Dihydroxyacetone kinase
E4Z98_08910	ENOG4105CHR	reductase
E4Z98_08990	ENOG4105C19	ABC transporter
E4Z98_08995	ENOG4107RBB	ABC transporter, permease
E4Z98_09105	ENOG4107X35	defense response to bacterium
E4Z98_09110	ENOG41069ER	domain protein
E4Z98_09190	ENOG4108UJD	30S ribosomal protein S9
E4Z98_09195	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E4Z98_09210	ENOG4108JJB	ABC transporter
E4Z98_09215	ENOG4108JJB	ABC transporter
E4Z98_09220	ENOG4108ZT0	50S ribosomal protein l17
E4Z98_09225	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4Z98_09230	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
E4Z98_09235	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4Z98_09245	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E4Z98_09250	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E4Z98_09255	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E4Z98_09260	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E4Z98_09265	ENOG4105VPB	50S ribosomal protein L30
E4Z98_09270	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E4Z98_09275	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E4Z98_09280	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E4Z98_09285	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E4Z98_09290	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E4Z98_09295	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4Z98_09300	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E4Z98_09310	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E4Z98_09315	ENOG41082SA	50s ribosomal protein l29
E4Z98_09320	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E4Z98_09325	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E4Z98_09330	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E4Z98_09335	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E4Z98_09340	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4Z98_09345	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E4Z98_09350	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E4Z98_09355	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E4Z98_09360	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
E4Z98_09370	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E4Z98_09375	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E4Z98_09380	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E4Z98_09385	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E4Z98_09390	ENOG4105E66	phosphoriboisomerase A
E4Z98_09395	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E4Z98_09410	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
E4Z98_09415	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
E4Z98_09420	ENOG4105X96	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)
E4Z98_09425	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
E4Z98_09430	ENOG4107QW4	alcohol dehydrogenase
E4Z98_09435	ENOG4105BZ1	(ABC) transporter
E4Z98_09450	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
E4Z98_09455	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
E4Z98_09460	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
E4Z98_09470	ENOG4105UIB	(ABC) transporter
E4Z98_09475	ENOG4108JQ9	ABC transporter
E4Z98_09480	ENOG4105DIH	basic membrane
E4Z98_09490	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
E4Z98_09495	ENOG4105ETE	Transcriptional regulator (LacI family
E4Z98_09500	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E4Z98_09570	ENOG4105K4H	Nlp p60 protein
E4Z98_09630	ENOG4108IYH	Dna topoisomerase
E4Z98_09635	ENOG4108Q9H	CobQ/CobB/MinD/ParA nucleotide binding domain
E4Z98_09680	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E4Z98_09910	ENOG4108UUM	single-stranded DNA-binding protein
E4Z98_09970	ENOG4106HDD