locus-tag	class	description
BHY08_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BHY08_00010	COG0592	DNA-directed DNA polymerase activity
BHY08_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BHY08_00030	COG0187	DNA topoisomerase II activity
BHY08_00045	COG0360	Binds together with S18 to 16S ribosomal RNA
BHY08_00050	COG0629	single-stranded DNA binding
BHY08_00060	COG0359	binds to the 23S rRNA
BHY08_00065	COG0305	Participates in initiation and elongation during chromosome replication
BHY08_00070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BHY08_00075	COG1307	EDD domain protein, DegV family
BHY08_00090	COG0488	(ABC) transporter
BHY08_00095	COG0142	geranyltranstransferase activity
BHY08_00135	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BHY08_00145	COG1744	ABC transporter substrate-binding protein PnrA-like
BHY08_00165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BHY08_00170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BHY08_00175	COG0813	purine-nucleoside phosphorylase activity
BHY08_00185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BHY08_00190	COG0477	Major facilitator Superfamily
BHY08_00205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BHY08_00210	COG4565	transcriptional regulatory protein
BHY08_00215	COG3290	protein histidine kinase activity
BHY08_00220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BHY08_00230	COG0671	phosphoesterase, PA-phosphatase related
BHY08_00250	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHY08_00250	COG1388	LysM domain
BHY08_00255	COG0495	leucyl-tRNA aminoacylation
BHY08_00260	COG2244	polysaccharide biosynthetic process
BHY08_00265	COG1187	pseudouridine synthase activity
BHY08_00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHY08_00275	COG0584	glycerophosphoryl diester phosphodiesterase
BHY08_00280	COG1136	(ABC) transporter
BHY08_00280	COG0577	efflux transmembrane transporter activity
BHY08_00280	COG0577	efflux transmembrane transporter activity
BHY08_00280	COG1136	(ABC) transporter
BHY08_00310	COG2816	NAD+ diphosphatase activity
BHY08_00325	COG1126	abc transporter atp-binding protein
BHY08_00330	COG0765	amino acid transport
BHY08_00340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BHY08_00360	COG3620	sequence-specific DNA binding
BHY08_00385	COG0039	L-malate dehydrogenase activity
BHY08_00390	COG0193	aminoacyl-tRNA hydrolase activity
BHY08_00395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BHY08_00400	COG2244	polysaccharide biosynthetic process
BHY08_00405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BHY08_00415	COG1098	S1 RNA binding domain
BHY08_00420	COG0037	tRNA processing
BHY08_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BHY08_00440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHY08_00445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BHY08_00575	COG4463	regulation of RNA biosynthetic process
BHY08_00580	COG0542	response to heat
BHY08_00595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHY08_00600	COG1271	oxidase subunit
BHY08_00605	COG1294	oxidase, subunit
BHY08_00610	COG4988	ABC transporter
BHY08_00615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BHY08_00630	COG0475	glutathione-regulated potassium exporter activity
BHY08_00655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHY08_00660	COG3679	Belongs to the UPF0342 family
BHY08_00675	COG3481	metal-dependent phosphohydrolase, HD sub domain
BHY08_00680	COG3764	Sortase (surface protein transpeptidase)
BHY08_00690	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHY08_00695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BHY08_00705	COG0736	holo-[acyl-carrier-protein] synthase activity
BHY08_00725	COG1561	YicC-like family, N-terminal region
BHY08_00730	COG0194	GDP metabolic process
BHY08_00735	COG1758	RNA polymerase activity
BHY08_00740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BHY08_00750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BHY08_00755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BHY08_00755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHY08_00765	COG2815	serine threonine protein kinase
BHY08_00765	COG0515	serine threonine protein kinase
BHY08_00770	COG1162	GTPase activity
BHY08_00775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BHY08_00795	COG1461	Dihydroxyacetone kinase
BHY08_00805	COG0416	fatty acid biosynthetic process
BHY08_00810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHY08_00850	COG1136	(ABC) transporter
BHY08_00905	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BHY08_00910	COG1028	Short-chain dehydrogenase reductase Sdr
BHY08_00920	COG0800	Aldolase
BHY08_00935	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_00935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_00940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BHY08_00945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_00950	COG3715	PTS system
BHY08_00980	COG2188	Transcriptional regulator
BHY08_00985	COG2222	sugar isomerase
BHY08_00990	COG3684	Belongs to the aldolase LacD family
BHY08_01005	COG1438	arginine binding
BHY08_01015	COG0018	arginyl-trna synthetase
BHY08_01020	COG1349	DNA-binding transcription factor activity
BHY08_01025	COG1105	Belongs to the carbohydrate kinase PfkB family
BHY08_01030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHY08_01030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHY08_01030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHY08_01035	COG2918	glutathione biosynthetic process
BHY08_01035	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHY08_01040	COG3711	transcriptional antiterminator
BHY08_01045	COG1263	PTS System
BHY08_01045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_01045	COG2190	(PTS) system
BHY08_01050	COG2723	6-phospho-beta-galactosidase activity
BHY08_01060	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_01065	COG5506	Protein of unknown function (DUF1694)
BHY08_01070	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BHY08_01075	COG4605	iron ion homeostasis
BHY08_01080	COG4604	ABC transporter, ATP-binding protein
BHY08_01085	COG4607	ABC-type enterochelin transport system periplasmic component
BHY08_01095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_01115	COG1447	Phosphotransferase system cellobiose-specific component IIA
BHY08_01130	COG1737	Transcriptional regulator
BHY08_01135	COG2246	polysaccharide biosynthetic process
BHY08_01145	COG0463	Glycosyl transferase, family 2
BHY08_01170	COG4493	Belongs to the UPF0637 family
BHY08_01180	COG0084	hydrolase, TatD family'
BHY08_01185	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BHY08_01190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BHY08_01200	COG3842	ATPase activity
BHY08_01205	COG1803	Methylglyoxal synthase
BHY08_01210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BHY08_01215	COG1011	Hydrolase
BHY08_01225	COG1132	(ABC) transporter
BHY08_01240	COG1388	LysM domain
BHY08_01240	COG3584	3D domain protein
BHY08_01245	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHY08_01250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BHY08_01255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_01265	COG4608	Belongs to the ABC transporter superfamily
BHY08_01270	COG0601	transmembrane transport
BHY08_01275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BHY08_01280	COG0747	negative chemotaxis
BHY08_01285	COG0571	ribonuclease III activity
BHY08_01290	COG1196	nuclear chromosome segregation
BHY08_01295	COG0561	phosphatase activity
BHY08_01300	COG0552	protein localization to endoplasmic reticulum
BHY08_01305	COG1349	DNA-binding transcription factor activity
BHY08_01310	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_01320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHY08_01325	COG3962	Belongs to the TPP enzyme family
BHY08_01330	COG1082	Xylose isomerase domain protein TIM barrel
BHY08_01335	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BHY08_01340	COG0673	inositol 2-dehydrogenase activity
BHY08_01365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BHY08_01385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHY08_01390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHY08_01395	COG1780	Probably involved in ribonucleotide reductase function
BHY08_01400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BHY08_01425	COG5002	protein histidine kinase activity
BHY08_01440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BHY08_01445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHY08_01450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BHY08_01465	COG2003	Belongs to the UPF0758 family
BHY08_01525	COG3316	Transposase and inactivated derivatives
BHY08_01530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHY08_01550	COG3711	transcriptional antiterminator
BHY08_01590	COG2003	Belongs to the UPF0758 family
BHY08_01640	COG1136	(ABC) transporter
BHY08_01645	COG0577	efflux transmembrane transporter activity
BHY08_01650	COG0745	RESPONSE REGULATOR receiver
BHY08_01655	COG5002	protein histidine kinase activity
BHY08_01670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BHY08_01690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BHY08_01695	COG0402	S-adenosylhomocysteine deaminase activity
BHY08_01700	COG2272	Belongs to the type-B carboxylesterase lipase family
BHY08_01725	COG2188	Transcriptional regulator
BHY08_01730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHY08_01735	COG1446	asparaginase
BHY08_01740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_01745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_01765	COG1175	transmembrane transport
BHY08_01780	COG3842	ATPase activity
BHY08_01785	COG1349	DNA-binding transcription factor activity
BHY08_01795	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BHY08_01800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHY08_01815	COG0494	nUDIX hydrolase
BHY08_01830	COG0625	glutathione transferase activity
BHY08_01870	COG0783	Belongs to the Dps family
BHY08_01910	COG0318	PFAM AMP-dependent synthetase and ligase
BHY08_01915	COG1169	isochorismate synthase
BHY08_01920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BHY08_01925	COG0596	Alpha beta hydrolase
BHY08_01930	COG4948	Mandelate Racemase Muconate Lactonizing
BHY08_01935	COG2252	PERMEase
BHY08_01940	COG0402	S-adenosylhomocysteine deaminase activity
BHY08_01950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BHY08_01955	COG0431	NADPH-dependent FMN reductase
BHY08_01960	COG1854	S-ribosylhomocysteine lyase activity
BHY08_01965	COG3443	Belongs to the bacterial solute-binding protein 9 family
BHY08_01965	COG0803	Belongs to the bacterial solute-binding protein 9 family
BHY08_01975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BHY08_01985	COG0523	cobalamin synthesis protein
BHY08_02000	COG0142	geranyltranstransferase activity
BHY08_02005	COG1346	cytolysis
BHY08_02015	COG3279	Response regulator of the LytR AlgR family
BHY08_02020	COG3275	phosphorelay sensor kinase activity
BHY08_02030	COG0789	Transcriptional regulator
BHY08_02035	COG0628	permease
BHY08_02045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BHY08_02050	COG1426	Protein conserved in bacteria
BHY08_02055	COG0300	oxidoreductase activity
BHY08_02060	COG0612	Peptidase, M16
BHY08_02065	COG0612	Peptidase, M16
BHY08_02070	COG1970	mechanosensitive ion channel activity
BHY08_02075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BHY08_02085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHY08_02090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BHY08_02095	COG1121	(ABC) transporter
BHY08_02100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BHY08_02105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BHY08_02110	COG1177	transmembrane transport
BHY08_02120	COG3842	ATPase activity
BHY08_02130	COG0604	alcohol dehydrogenase
BHY08_02135	COG1473	amidohydrolase
BHY08_02140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BHY08_02145	COG0038	chloride channel
BHY08_02155	COG0708	Exodeoxyribonuclease III
BHY08_02170	COG0802	atpase or kinase
BHY08_02175	COG0280	phosphate acetyltransferase
BHY08_02180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BHY08_02185	COG0561	phosphatase activity
BHY08_02195	COG2502	aspartate--ammonia ligase
BHY08_02200	COG1609	Transcriptional regulator
BHY08_02210	COG1175	transmembrane transport
BHY08_02215	COG0395	ABC-type sugar transport system, permease component
BHY08_02270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BHY08_02275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHY08_02285	COG1464	Belongs to the NlpA lipoprotein family
BHY08_02290	COG1473	amidohydrolase
BHY08_02295	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BHY08_02300	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BHY08_02320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHY08_02325	COG1959	2 iron, 2 sulfur cluster binding
BHY08_02345	COG1363	Peptidase, m42
BHY08_02350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHY08_02360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHY08_02365	COG4472	Bacterial protein of unknown function (DUF965)
BHY08_02370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BHY08_02375	COG3906	Belongs to the UPF0473 family
BHY08_02390	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BHY08_02405	COG1193	negative regulation of DNA recombination
BHY08_02410	COG3118	belongs to the thioredoxin family
BHY08_02415	COG0322	excinuclease ABC activity
BHY08_02425	COG1252	NADH dehydrogenase
BHY08_02430	COG1760	l-serine dehydratase
BHY08_02435	COG1760	l-serine dehydratase
BHY08_02440	COG1058	Belongs to the CinA family
BHY08_02440	COG1546	Belongs to the CinA family
BHY08_02445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BHY08_02450	COG1418	mRNA catabolic process
BHY08_02455	COG1328	CTP reductase activity
BHY08_02470	COG0745	RESPONSE REGULATOR receiver
BHY08_02475	COG1363	Peptidase, m42
BHY08_02480	COG1234	tRNA 3'-trailer cleavage
BHY08_02485	COG0095	Lipoate-protein ligase
BHY08_02490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHY08_02500	COG0537	adenosine 5'-monophosphoramidase activity
BHY08_02505	COG1131	(ABC) transporter
BHY08_02510	COG4473	ABC transporter
BHY08_02515	COG0510	thiamine kinase activity
BHY08_02520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BHY08_02530	COG2376	Dihydroxyacetone kinase
BHY08_02535	COG1461	Dihydroxyacetone kinase
BHY08_02540	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BHY08_02550	COG2376	Dihydroxyacetone kinase
BHY08_02565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BHY08_02570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BHY08_02575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BHY08_02580	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BHY08_02600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BHY08_02610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BHY08_02615	COG0006	proline dipeptidase activity
BHY08_02620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHY08_02625	COG1302	Protein conserved in bacteria
BHY08_02630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHY08_02640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BHY08_02645	COG1570	exodeoxyribonuclease VII activity
BHY08_02650	COG1722	exodeoxyribonuclease VII activity
BHY08_02655	COG0142	geranyltranstransferase activity
BHY08_02660	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BHY08_02665	COG1438	arginine binding
BHY08_02670	COG0497	DNA recombination
BHY08_02685	COG2001	Belongs to the MraZ family
BHY08_02690	COG0275	rRNA processing
BHY08_02695	COG4839	cell division protein FtsL
BHY08_02700	COG0768	penicillin binding
BHY08_02705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHY08_02710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BHY08_02715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BHY08_02720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BHY08_02725	COG0849	cell division
BHY08_02730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BHY08_02735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BHY08_02740	COG1799	cell septum assembly
BHY08_02755	COG3599	regulation of cell shape
BHY08_02760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BHY08_02775	COG1609	Transcriptional regulator
BHY08_02780	COG2723	6-phospho-beta-galactosidase activity
BHY08_02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_02785	COG1263	PTS System
BHY08_02785	COG2190	(PTS) system
BHY08_02790	COG3711	transcriptional antiterminator
BHY08_02795	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BHY08_02800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BHY08_02815	COG0363	glucosamine-6-phosphate deaminase activity
BHY08_02820	COG0765	amino acid transport
BHY08_02825	COG1126	abc transporter atp-binding protein
BHY08_02830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_02840	COG0531	amino acid
BHY08_02845	COG0673	inositol 2-dehydrogenase activity
BHY08_02850	COG1942	4-Oxalocrotonate Tautomerase
BHY08_02875	COG3976	FMN-binding domain protein
BHY08_02875	COG0431	NADPH-dependent FMN reductase
BHY08_02875	COG1053	succinate dehydrogenase
BHY08_02890	COG0628	permease
BHY08_02895	COG0583	DNA-binding transcription factor activity
BHY08_02905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BHY08_02920	COG1174	glycine betaine transport
BHY08_02930	COG1174	glycine betaine transport
BHY08_02935	COG0436	Aminotransferase
BHY08_02960	COG1695	Transcriptional regulator
BHY08_02985	COG1136	(ABC) transporter
BHY08_03000	COG2268	Band 7 protein
BHY08_03005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BHY08_03020	COG2076	Multidrug Resistance protein
BHY08_03025	COG2076	Multidrug Resistance protein
BHY08_03035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BHY08_03040	COG1595	DNA-templated transcription, initiation
BHY08_03055	COG0542	response to heat
BHY08_03065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHY08_03070	COG0438	transferase activity, transferring glycosyl groups
BHY08_03085	COG2084	Dehydrogenase
BHY08_03090	COG4703	Protein of unknown function (DUF1797)
BHY08_03100	COG0544	peptidyl-prolyl cis-trans isomerase activity
BHY08_03105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BHY08_03110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BHY08_03115	COG0745	RESPONSE REGULATOR receiver
BHY08_03120	COG5002	protein histidine kinase activity
BHY08_03125	COG3682	Transcriptional regulator
BHY08_03130	COG2217	Heavy metal translocating P-type atpase
BHY08_03135	COG3942	CHAP domain
BHY08_03135	COG1388	LysM domain
BHY08_03145	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHY08_03150	COG1940	carbohydrate kinase activity
BHY08_03165	COG0450	alkyl hydroperoxide reductase
BHY08_03190	COG4175	Glycine betaine
BHY08_03190	COG3448	diguanylate cyclase activity
BHY08_03205	COG3973	AAA domain
BHY08_03215	COG4716	Myosin-crossreactive antigen
BHY08_03225	COG3425	synthase
BHY08_03230	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BHY08_03235	COG1363	Peptidase, m42
BHY08_03245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BHY08_03260	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
BHY08_03265	COG1518	maintenance of DNA repeat elements
BHY08_03270	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BHY08_03280	COG2814	Major facilitator Superfamily
BHY08_03295	COG0367	asparagine synthase
BHY08_03305	COG1794	racemase activity, acting on amino acids and derivatives
BHY08_03310	COG1506	peptidase
BHY08_03310	COG0823	Involved in the tonB-independent uptake of proteins
BHY08_03310	COG4946	Tricorn protease homolog
BHY08_03320	COG1268	BioY protein
BHY08_03325	COG0726	polysaccharide deacetylase
BHY08_03335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHY08_03350	COG2824	Alkylphosphonate utilization operon protein PhnA
BHY08_03355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BHY08_03360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHY08_03375	COG2197	response regulator
BHY08_03380	COG0569	domain protein
BHY08_03385	COG4841	protein insertion into membrane
BHY08_03395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BHY08_03400	COG4838	Belongs to the UPF0358 family
BHY08_03405	COG0772	Belongs to the SEDS family
BHY08_03410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BHY08_03425	COG4471	UPF0298 protein
BHY08_03430	COG0742	ribosomal rna small subunit methyltransferase
BHY08_03435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BHY08_03440	COG3480	Lon protease (S16) C-terminal proteolytic domain
BHY08_03445	COG1596	polysaccharide export
BHY08_03445	COG1555	photosystem II stabilization
BHY08_03455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BHY08_03460	COG2131	deaminase
BHY08_03465	COG0658	competence protein
BHY08_03465	COG2333	competence protein COMEC
BHY08_03470	COG1466	dna polymerase III delta subunit
BHY08_03475	COG0268	Binds directly to 16S ribosomal RNA
BHY08_03480	COG1307	EDD domain protein, DegV family
BHY08_03490	COG2217	Heavy metal translocating P-type atpase
BHY08_03495	COG1968	undecaprenyl-diphosphatase activity
BHY08_03520	COG0052	Belongs to the universal ribosomal protein uS2 family
BHY08_03525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BHY08_03530	COG0528	UMP kinase activity
BHY08_03535	COG0233	cytoplasmic translational termination
BHY08_03540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BHY08_03545	COG4589	Belongs to the CDS family
BHY08_03550	COG0750	zinc metalloprotease
BHY08_03555	COG0442	prolyl-tRNA aminoacylation
BHY08_03565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BHY08_03570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BHY08_03575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BHY08_03580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BHY08_03595	COG0779	Required for maturation of 30S ribosomal subunits
BHY08_03600	COG0195	Participates in both transcription termination and antitermination
BHY08_03605	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BHY08_03620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BHY08_03625	COG0673	inositol 2-dehydrogenase activity
BHY08_03635	COG0196	riboflavin kinase activity
BHY08_03640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BHY08_03645	COG1420	regulation of RNA biosynthetic process
BHY08_03655	COG0443	Heat shock 70 kDa protein
BHY08_03660	COG0484	heat shock protein binding
BHY08_03665	COG0803	Belongs to the bacterial solute-binding protein 9 family
BHY08_03670	COG0697	spore germination
BHY08_03675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BHY08_03680	COG0561	phosphatase activity
BHY08_03685	COG1078	dGTPase activity
BHY08_03690	COG0095	Lipoate-protein ligase
BHY08_03700	COG3343	RNA polymerase activity
BHY08_03710	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_03715	COG0191	fructose-bisphosphate aldolase activity
BHY08_03720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BHY08_03725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BHY08_03730	COG0254	rRNA binding
BHY08_03745	COG1368	sulfuric ester hydrolase activity
BHY08_03760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BHY08_03770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BHY08_03775	COG0336	Belongs to the RNA methyltransferase TrmD family
BHY08_03780	COG0335	large ribosomal subunit rRNA binding
BHY08_03790	COG1098	S1 RNA binding domain
BHY08_03845	COG1199	ATP-dependent helicase activity
BHY08_03845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BHY08_03855	COG0436	Aminotransferase
BHY08_03870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BHY08_03885	COG1316	TRANSCRIPTIONal
BHY08_03890	COG3579	cysteine-type endopeptidase activity
BHY08_03895	COG0556	nucleotide-excision repair
BHY08_03900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BHY08_03905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BHY08_03910	COG0573	inorganic phosphate transmembrane transporter activity
BHY08_03915	COG0581	inorganic phosphate transmembrane transporter activity
BHY08_03920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BHY08_03925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BHY08_03930	COG0704	Plays a role in the regulation of phosphate uptake
BHY08_03935	COG0137	argininosuccinate synthase activity
BHY08_03945	COG0741	lytic transglycosylase activity
BHY08_03945	COG1196	nuclear chromosome segregation
BHY08_03945	COG0739	heme binding
BHY08_03960	COG1983	PspC domain protein
BHY08_03965	COG1950	PFAM Membrane protein of
BHY08_03980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHY08_03995	COG1131	(ABC) transporter
BHY08_04000	COG0228	four-way junction DNA binding
BHY08_04005	COG1837	Belongs to the UPF0109 family
BHY08_04010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_04015	COG0574	Belongs to the PEP-utilizing enzyme family
BHY08_04015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHY08_04020	COG0517	IMP dehydrogenase activity
BHY08_04025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BHY08_04045	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHY08_04050	COG1937	Protein conserved in bacteria
BHY08_04055	COG2367	Beta-lactamase
BHY08_04060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BHY08_04065	COG0302	gtp cyclohydrolase
BHY08_04065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BHY08_04070	COG0302	gtp cyclohydrolase
BHY08_04075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BHY08_04110	COG2207	Transcriptional regulator
BHY08_04125	COG1609	Transcriptional regulator
BHY08_04135	COG1869	D-ribose catabolic process
BHY08_04140	COG4975	Glucose uptake
BHY08_04175	COG1979	alcohol dehydrogenase
BHY08_04180	COG0247	lactate metabolic process
BHY08_04185	COG1139	Iron-sulfur cluster binding protein
BHY08_04190	COG1556	Lactate utilization protein
BHY08_04210	COG0765	amino acid transport
BHY08_04215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_04220	COG1942	4-Oxalocrotonate Tautomerase
BHY08_04235	COG0557	exoribonuclease II activity
BHY08_04240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BHY08_04245	COG0356	it plays a direct role in the translocation of protons across the membrane
BHY08_04250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHY08_04255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BHY08_04260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHY08_04265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BHY08_04270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BHY08_04275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BHY08_04280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BHY08_04305	COG2508	Transcriptional regulator
BHY08_04310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BHY08_04325	COG1129	ABC transporter
BHY08_04340	COG0706	membrane insertase activity
BHY08_04345	COG1254	Belongs to the acylphosphatase family
BHY08_04350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHY08_04360	COG1733	regulation of RNA biosynthetic process
BHY08_04365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BHY08_04370	COG0072	phenylalanine-tRNA ligase activity
BHY08_04370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHY08_04375	COG1686	Belongs to the peptidase S11 family
BHY08_04380	COG0656	L-ascorbic acid biosynthetic process
BHY08_04385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHY08_04390	COG1104	cysteine desulfurase activity
BHY08_04400	COG0482	sulfurtransferase activity
BHY08_04420	COG1126	abc transporter atp-binding protein
BHY08_04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_04440	COG4807	Protein conserved in bacteria
BHY08_04445	COG1671	Belongs to the UPF0178 family
BHY08_04450	COG2188	Transcriptional regulator
BHY08_04460	COG2723	6-phospho-beta-galactosidase activity
BHY08_04470	COG2860	membrane
BHY08_04475	COG0488	(ABC) transporter
BHY08_04480	COG0280	phosphate acetyltransferase
BHY08_04485	COG3426	butyrate kinase activity
BHY08_04490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHY08_04495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BHY08_04500	COG0022	dehydrogenase e1 component
BHY08_04505	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHY08_04515	COG0583	DNA-binding transcription factor activity
BHY08_04520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BHY08_04525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHY08_04545	COG0772	Belongs to the SEDS family
BHY08_04550	COG0492	ferredoxin-NADP+ reductase activity
BHY08_04555	COG1609	Transcriptional regulator
BHY08_04560	COG1272	protein, Hemolysin III
BHY08_04565	COG1307	EDD domain protein, DegV family
BHY08_04570	COG2755	lipolytic protein G-D-S-L family
BHY08_04580	COG4479	Belongs to the UPF0346 family
BHY08_04585	COG3409	Peptidoglycan-binding domain 1 protein
BHY08_04585	COG0793	Belongs to the peptidase S41A family
BHY08_04600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BHY08_04605	COG0758	DNA mediated transformation
BHY08_04610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHY08_04615	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BHY08_04620	COG4974	Belongs to the 'phage' integrase family
BHY08_04625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BHY08_04630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BHY08_04635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BHY08_04645	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BHY08_04660	COG1610	YqeY-like protein
BHY08_04665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BHY08_04670	COG1674	ftsk spoiiie
BHY08_04670	COG1280	lysine exporter protein (LysE YggA)
BHY08_04675	COG0463	Glycosyl transferase, family 2
BHY08_04695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BHY08_04700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BHY08_04705	COG0154	amidase activity
BHY08_04715	COG1597	lipid kinase activity
BHY08_04720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BHY08_04750	COG2514	catechol 2,3-dioxygenase activity
BHY08_04760	COG1687	branched-chain amino acid
BHY08_04765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BHY08_04775	COG1368	sulfuric ester hydrolase activity
BHY08_04780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHY08_04785	COG0710	3-dehydroquinate dehydratase activity
BHY08_04790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BHY08_04800	COG2081	HI0933 family
BHY08_04805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BHY08_04830	COG0187	DNA topoisomerase II activity
BHY08_04835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BHY08_04840	COG1882	Formate acetyltransferase
BHY08_04845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BHY08_04855	COG1227	inorganic diphosphatase activity
BHY08_04865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHY08_04895	COG0745	RESPONSE REGULATOR receiver
BHY08_04900	COG5002	protein histidine kinase activity
BHY08_04900	COG3850	Histidine kinase
BHY08_04905	COG4476	Belongs to the UPF0223 family
BHY08_04910	COG0483	inositol monophosphate 1-phosphatase activity
BHY08_04920	COG2384	SAM-dependent methyltransferase
BHY08_04925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BHY08_04930	COG2195	Cleaves the N-terminal amino acid of tripeptides
BHY08_04935	COG0542	response to heat
BHY08_04960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHY08_04985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHY08_04985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHY08_04990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BHY08_04995	COG0237	dephospho-CoA kinase activity
BHY08_05005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BHY08_05015	COG1484	DNA-dependent DNA replication
BHY08_05025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BHY08_05030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BHY08_05035	COG1832	CoA-binding protein
BHY08_05055	COG3639	organic phosphonate transmembrane transporter activity
BHY08_05060	COG0737	Belongs to the 5'-nucleotidase family
BHY08_05070	COG2337	Toxic component of a toxin-antitoxin (TA) module
BHY08_05080	COG1160	GTP binding
BHY08_05095	COG0481	GTPase activity
BHY08_05120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHY08_05130	COG2217	Heavy metal translocating P-type atpase
BHY08_05135	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BHY08_05145	COG0582	viral genome integration into host DNA
BHY08_05155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BHY08_05160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BHY08_05175	COG0287	Prephenate dehydrogenase
BHY08_05185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BHY08_05190	COG0077	Prephenate dehydratase
BHY08_05245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BHY08_05265	COG4120	Belongs to the binding-protein-dependent transport system permease family
BHY08_05310	COG3223	Belongs to the PsiE family
BHY08_05315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BHY08_05320	COG0284	orotidine-5'-phosphate decarboxylase activity
BHY08_05325	COG0167	dihydroorotate dehydrogenase activity
BHY08_05330	COG0543	2 iron, 2 sulfur cluster binding
BHY08_05345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BHY08_05350	COG0540	Belongs to the ATCase OTCase family
BHY08_05355	COG2233	PERMEase
BHY08_05360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BHY08_05365	COG0564	pseudouridine synthase activity
BHY08_05370	COG1823	symporter activity
BHY08_05375	COG0251	oxidation-reduction process
BHY08_05380	COG0626	cystathionine gamma-synthase activity
BHY08_05385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BHY08_05400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BHY08_05405	COG0577	efflux transmembrane transporter activity
BHY08_05410	COG1136	(ABC) transporter
BHY08_05425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHY08_05435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BHY08_05440	COG2252	PERMEase
BHY08_05445	COG0577	efflux transmembrane transporter activity
BHY08_05445	COG1136	(ABC) transporter
BHY08_05450	COG1136	(ABC) transporter
BHY08_05465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHY08_05470	COG0358	DNA primase activity
BHY08_05475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BHY08_05500	COG1132	(ABC) transporter
BHY08_05505	COG1132	(ABC) transporter
BHY08_05510	COG3763	UPF0154 protein
BHY08_05515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BHY08_05520	COG0765	amino acid transport
BHY08_05525	COG0765	amino acid transport
BHY08_05530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_05540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BHY08_05550	COG0751	glycine-tRNA ligase activity
BHY08_05555	COG0752	glycyl-tRNA synthetase alpha subunit
BHY08_05560	COG1381	Involved in DNA repair and RecF pathway recombination
BHY08_05565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BHY08_05575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BHY08_05585	COG1702	phosphate starvation-inducible protein PhoH
BHY08_05620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BHY08_05625	COG0719	Fe-S assembly protein
BHY08_05640	COG1464	Belongs to the NlpA lipoprotein family
BHY08_05645	COG2011	ABC-type metal ion transport system permease component
BHY08_05650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHY08_05655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BHY08_05665	COG3716	PTS system mannose fructose sorbose family IID component
BHY08_05670	COG3715	PTS system
BHY08_05690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_05690	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_05695	COG0513	Belongs to the DEAD box helicase family
BHY08_05705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BHY08_05710	COG1307	EDD domain protein, DegV family
BHY08_05715	COG1316	TRANSCRIPTIONal
BHY08_05725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHY08_05735	COG0393	Putative heavy-metal-binding
BHY08_05745	COG0789	Transcriptional regulator
BHY08_05750	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BHY08_05760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BHY08_05765	COG0584	glycerophosphoryl diester phosphodiesterase
BHY08_05775	COG1573	uracil-dna glycosylase
BHY08_05780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BHY08_05785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BHY08_05790	COG1940	carbohydrate kinase activity
BHY08_05800	COG0457	Tetratricopeptide repeat
BHY08_05800	COG0705	Rhomboid family
BHY08_05805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BHY08_05820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BHY08_05835	COG0726	polysaccharide deacetylase
BHY08_05840	COG0076	glutamate decarboxylase activity
BHY08_05865	COG0460	homoserine dehydrogenase
BHY08_05870	COG0527	aspartate kinase activity
BHY08_05875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BHY08_05885	COG3759	membrane
BHY08_05895	COG0778	Nitroreductase
BHY08_05900	COG0604	alcohol dehydrogenase
BHY08_05905	COG1846	Transcriptional regulator
BHY08_05920	COG2151	metal-sulfur cluster biosynthetic enzyme
BHY08_05925	COG0825	malonyl-CoA metabolic process
BHY08_05930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BHY08_05935	COG0439	Biotin carboxylase
BHY08_05940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHY08_05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHY08_05960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BHY08_05975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHY08_05985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_05990	COG0778	Nitroreductase
BHY08_05995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BHY08_06000	COG0798	PFAM Bile acid sodium symporter
BHY08_06030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BHY08_06035	COG1073	alpha beta
BHY08_06040	COG2153	protein acetylation
BHY08_06055	COG0668	transmembrane transport
BHY08_06065	COG0517	IMP dehydrogenase activity
BHY08_06075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BHY08_06085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BHY08_06090	COG0456	acetyltransferase
BHY08_06095	COG0456	acetyltransferase
BHY08_06095	COG1214	PFAM Peptidase M22, glycoprotease
BHY08_06100	COG1214	PFAM Peptidase M22, glycoprotease
BHY08_06110	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BHY08_06115	COG0363	glucosamine-6-phosphate deaminase activity
BHY08_06120	COG0710	3-dehydroquinate dehydratase activity
BHY08_06125	COG0640	Transcriptional regulator
BHY08_06130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHY08_06145	COG0617	tRNA 3'-terminal CCA addition
BHY08_06150	COG1694	Mazg nucleotide pyrophosphohydrolase
BHY08_06155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_06165	COG0457	Tetratricopeptide repeat
BHY08_06170	COG2261	transglycosylase associated protein
BHY08_06180	COG1160	GTP binding
BHY08_06185	COG0539	negative regulation of cytoplasmic translation
BHY08_06200	COG0514	ATP-dependent DNA helicase (RecQ)
BHY08_06215	COG2755	lipolytic protein G-D-S-L family
BHY08_06215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BHY08_06225	COG1187	pseudouridine synthase activity
BHY08_06230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BHY08_06235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BHY08_06250	COG0735	belongs to the Fur family
BHY08_06255	COG2996	Protein conserved in bacteria
BHY08_06260	COG2814	Major facilitator Superfamily
BHY08_06270	COG0205	6-phosphofructokinase activity
BHY08_06275	COG0587	DNA-directed DNA polymerase activity
BHY08_06285	COG2814	Major facilitator Superfamily
BHY08_06290	COG0477	Major facilitator Superfamily
BHY08_06295	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BHY08_06305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BHY08_06310	COG0768	penicillin binding
BHY08_06320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BHY08_06335	COG1040	competence protein
BHY08_06340	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BHY08_06360	COG1739	Uncharacterized protein family UPF0029
BHY08_06390	COG0517	IMP dehydrogenase activity
BHY08_06390	COG0516	GMP reductase activity
BHY08_06395	COG0410	ABC transporter
BHY08_06400	COG0411	ABC transporter
BHY08_06410	COG0559	Belongs to the binding-protein-dependent transport system permease family
BHY08_06420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BHY08_06430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BHY08_06450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BHY08_06455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BHY08_06460	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BHY08_06465	COG3257	ureidoglycine aminohydrolase activity
BHY08_06470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHY08_06480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BHY08_06485	COG1953	Uracil, thiamine, allantoin
BHY08_06500	COG0772	Belongs to the SEDS family
BHY08_06510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BHY08_06515	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BHY08_06520	COG1481	regulation of sporulation
BHY08_06525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BHY08_06530	COG1660	Displays ATPase and GTPase activities
BHY08_06535	COG2177	Part of the ABC transporter FtsEX involved in
BHY08_06540	COG2884	Cell division ATP-binding protein ftsE
BHY08_06545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BHY08_06550	COG0653	protein targeting
BHY08_06555	COG0561	phosphatase activity
BHY08_06575	COG0148	phosphopyruvate hydratase activity
BHY08_06580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BHY08_06585	COG0149	triose-phosphate isomerase activity
BHY08_06600	COG2390	Transcriptional regulator
BHY08_06605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BHY08_06615	COG0740	serine-type endopeptidase activity
BHY08_06625	COG5002	protein histidine kinase activity
BHY08_06630	COG0745	RESPONSE REGULATOR receiver
BHY08_06635	COG1132	(ABC) transporter
BHY08_06640	COG1132	(ABC) transporter
BHY08_06645	COG0516	GMP reductase activity
BHY08_06655	COG1131	(ABC) transporter
BHY08_06660	COG4989	oxidoreductase activity
BHY08_06675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHY08_06695	COG4467	Involved in initiation control of chromosome replication
BHY08_06705	COG0470	DNA polymerase III
BHY08_06710	COG3870	Protein conserved in bacteria
BHY08_06715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BHY08_06720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BHY08_06725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BHY08_06730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BHY08_06740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BHY08_06765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BHY08_06770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BHY08_06775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BHY08_06795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BHY08_06800	COG0572	uridine kinase
BHY08_06805	COG4619	ABC transporter
BHY08_06810	COG0390	transport system, permease component
BHY08_06820	COG4608	Belongs to the ABC transporter superfamily
BHY08_06825	COG0444	Belongs to the ABC transporter superfamily
BHY08_06830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BHY08_06835	COG0601	transmembrane transport
BHY08_06845	COG4166	transmembrane transport
BHY08_06855	COG3716	PTS system mannose fructose sorbose family IID component
BHY08_06860	COG3715	PTS system
BHY08_06870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_06870	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHY08_06875	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_06875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_06880	COG1053	succinate dehydrogenase
BHY08_06910	COG1511	domain protein
BHY08_06915	COG0531	amino acid
BHY08_06925	COG0583	DNA-binding transcription factor activity
BHY08_06930	COG2855	membrane
BHY08_06935	COG1335	isochorismatase
BHY08_06950	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BHY08_06955	COG3853	Toxic anion resistance protein (TelA)
BHY08_06960	COG0735	belongs to the Fur family
BHY08_06965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BHY08_06970	COG1278	Cold shock
BHY08_06990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BHY08_06995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BHY08_07000	COG3442	glutamine amidotransferase
BHY08_07015	COG1482	cell wall glycoprotein biosynthetic process
BHY08_07030	COG1132	(ABC) transporter
BHY08_07045	COG0492	ferredoxin-NADP+ reductase activity
BHY08_07050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BHY08_07060	COG0647	UMP catabolic process
BHY08_07065	COG4470	Protein conserved in bacteria
BHY08_07070	COG0737	Belongs to the 5'-nucleotidase family
BHY08_07075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BHY08_07080	COG2365	Tyrosine phosphatase family
BHY08_07090	COG2249	NAD(P)H dehydrogenase (quinone) activity
BHY08_07100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BHY08_07105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BHY08_07110	COG0116	Belongs to the methyltransferase superfamily
BHY08_07125	COG3331	DNA recombination
BHY08_07130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHY08_07135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BHY08_07145	COG2070	2-Nitropropane dioxygenase
BHY08_07150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BHY08_07160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BHY08_07165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BHY08_07170	COG0009	L-threonylcarbamoyladenylate synthase
BHY08_07175	COG2890	protein-(glutamine-N5) methyltransferase activity
BHY08_07180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BHY08_07185	COG1435	thymidine kinase activity
BHY08_07190	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BHY08_07215	COG1378	Sugar-specific transcriptional regulator TrmB
BHY08_07220	COG1122	ATPase activity
BHY08_07225	COG4120	Belongs to the binding-protein-dependent transport system permease family
BHY08_07260	COG2706	6-phosphogluconolactonase activity
BHY08_07280	COG2195	Cleaves the N-terminal amino acid of tripeptides
BHY08_07285	COG4166	transmembrane transport
BHY08_07290	COG0765	amino acid transport
BHY08_07295	COG1126	abc transporter atp-binding protein
BHY08_07300	COG0436	Aminotransferase
BHY08_07310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BHY08_07315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHY08_07320	COG0509	glycine decarboxylation via glycine cleavage system
BHY08_07325	COG1393	Belongs to the ArsC family
BHY08_07335	COG0772	Belongs to the SEDS family
BHY08_07340	COG5416	Lipopolysaccharide assembly protein A domain
BHY08_07345	COG0300	oxidoreductase activity
BHY08_07355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BHY08_07360	COG2226	methyltransferase
BHY08_07385	COG1304	FMN binding
BHY08_07395	COG1323	Belongs to the UPF0348 family
BHY08_07400	COG2226	methyltransferase
BHY08_07410	COG1713	HD superfamily hydrolase involved in NAD metabolism
BHY08_07415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BHY08_07420	COG1534	Rna-binding protein
BHY08_07425	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BHY08_07435	COG1263	PTS System
BHY08_07435	COG2190	(PTS) system
BHY08_07435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_07440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_07440	COG2190	(PTS) system
BHY08_07440	COG1263	PTS System
BHY08_07445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BHY08_07450	COG1737	Transcriptional regulator
BHY08_07465	COG0138	bifunctional purine biosynthesis protein purh
BHY08_07470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BHY08_07475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BHY08_07485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BHY08_07495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BHY08_07500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BHY08_07505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BHY08_07510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BHY08_07515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BHY08_07520	COG1070	Carbohydrate kinase
BHY08_07530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BHY08_07535	COG1228	amidohydrolase
BHY08_07540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_07545	COG0124	histidyl-tRNA synthetase
BHY08_07550	COG2986	histidine ammonia-lyase
BHY08_07555	COG0531	amino acid
BHY08_07570	COG3404	Formiminotransferase-cyclodeaminase
BHY08_07585	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHY08_07585	COG3942	CHAP domain
BHY08_07595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BHY08_07615	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHY08_07650	COG1216	Glycosyl transferase, family 2
BHY08_07655	COG1091	dTDP-4-dehydrorhamnose reductase activity
BHY08_07660	COG1088	dTDP-glucose 4,6-dehydratase activity
BHY08_07670	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BHY08_07710	COG1253	flavin adenine dinucleotide binding
BHY08_07715	COG0628	permease
BHY08_07720	COG2153	protein acetylation
BHY08_07730	COG3557	Belongs to the UPF0374 family
BHY08_07735	COG1194	a g-specific adenine glycosylase
BHY08_07740	COG2137	regulation of response to DNA damage stimulus
BHY08_07775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BHY08_07830	COG1215	transferase activity, transferring glycosyl groups
BHY08_07840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BHY08_07865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BHY08_07865	COG0463	Glycosyl transferase, family 2
BHY08_07870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BHY08_07875	COG1682	transport, permease protein
BHY08_07880	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BHY08_07885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BHY08_07890	COG1134	teichoic acid transport
BHY08_07895	COG1316	TRANSCRIPTIONal
BHY08_07900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHY08_07905	COG1295	ribonuclease BN
BHY08_07910	COG0024	Methionine aminopeptidase
BHY08_07915	COG0716	FMN binding
BHY08_07925	COG2309	aminopeptidase activity
BHY08_07930	COG0301	tRNA thio-modification
BHY08_07935	COG1104	cysteine desulfurase activity
BHY08_07940	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BHY08_07950	COG4608	Belongs to the ABC transporter superfamily
BHY08_07955	COG0444	Belongs to the ABC transporter superfamily
BHY08_07960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BHY08_07975	COG1464	Belongs to the NlpA lipoprotein family
BHY08_07980	COG2011	ABC-type metal ion transport system permease component
BHY08_07985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHY08_08005	COG2183	response to ionizing radiation
BHY08_08025	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHY08_08030	COG1876	peptidase activity
BHY08_08040	COG4129	membrane
BHY08_08055	COG0577	efflux transmembrane transporter activity
BHY08_08060	COG1136	(ABC) transporter
BHY08_08065	COG0642	Histidine kinase
BHY08_08070	COG0745	RESPONSE REGULATOR receiver
BHY08_08080	COG0716	FMN binding
BHY08_08085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BHY08_08095	COG0584	glycerophosphoryl diester phosphodiesterase
BHY08_08100	COG3338	carbonate dehydratase activity
BHY08_08120	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BHY08_08125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHY08_08130	COG1696	Membrane protein involved in D-alanine export
BHY08_08170	COG1074	ATP-dependent DNA helicase activity
BHY08_08175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BHY08_08190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BHY08_08195	COG1121	(ABC) transporter
BHY08_08210	COG0504	CTP synthase activity
BHY08_08215	COG0659	secondary active sulfate transmembrane transporter activity
BHY08_08240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BHY08_08245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BHY08_08250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHY08_08255	COG0427	acetyl-CoA hydrolase
BHY08_08260	COG1024	Enoyl-CoA hydratase
BHY08_08265	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHY08_08270	COG1960	acyl-CoA dehydrogenase activity
BHY08_08285	COG1960	acyl-CoA dehydrogenase activity
BHY08_08290	COG0662	Cupin 2, conserved barrel domain protein
BHY08_08300	COG0590	tRNA wobble adenosine to inosine editing
BHY08_08310	COG2738	Putative neutral zinc metallopeptidase
BHY08_08320	COG2199	diguanylate cyclase activity
BHY08_08320	COG2203	Gaf domain
BHY08_08325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BHY08_08335	COG0366	Alpha amylase catalytic
BHY08_08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_08340	COG1263	PTS System
BHY08_08345	COG2188	Transcriptional regulator
BHY08_08350	COG1185	polyribonucleotide nucleotidyltransferase activity
BHY08_08355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BHY08_08360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BHY08_08365	COG0242	peptide deformylase activity
BHY08_08375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BHY08_08385	COG2239	Acts as a magnesium transporter
BHY08_08390	COG0564	pseudouridine synthase activity
BHY08_08395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BHY08_08400	COG2357	RelA SpoT domain protein
BHY08_08415	COG1164	Oligoendopeptidase f
BHY08_08425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BHY08_08430	COG0531	amino acid
BHY08_08440	COG0488	(ABC) transporter
BHY08_08445	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BHY08_08455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BHY08_08460	COG0459	protein refolding
BHY08_08485	COG0596	Alpha beta hydrolase
BHY08_08535	COG0217	transcriptional regulatory protein
BHY08_08545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BHY08_08550	COG4109	DRTGG domain
BHY08_08565	COG0444	Belongs to the ABC transporter superfamily
BHY08_08570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BHY08_08580	COG0747	negative chemotaxis
BHY08_08585	COG2226	methyltransferase
BHY08_08590	COG0829	nickel cation binding
BHY08_08595	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BHY08_08610	COG0804	urea catabolic process
BHY08_08615	COG0832	Belongs to the urease beta subunit family
BHY08_08620	COG0831	urea catabolic process
BHY08_08635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BHY08_08640	COG0351	phosphomethylpyrimidine kinase
BHY08_08660	COG0250	Participates in transcription elongation, termination and antitermination
BHY08_08670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BHY08_08695	COG1597	lipid kinase activity
BHY08_08700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BHY08_08705	COG0406	alpha-ribazole phosphatase activity
BHY08_08710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BHY08_08715	COG0500	methyltransferase
BHY08_08720	COG3142	Participates in the control of copper homeostasis
BHY08_08725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHY08_08730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BHY08_08735	COG1668	transmembrane transport
BHY08_08740	COG4152	abc transporter atp-binding protein
BHY08_08775	COG1454	alcohol dehydrogenase
BHY08_08775	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_08800	COG0673	inositol 2-dehydrogenase activity
BHY08_08805	COG1082	Xylose isomerase domain protein TIM barrel
BHY08_08820	COG2207	Transcriptional regulator
BHY08_08820	COG1917	Cupin 2, conserved barrel domain protein
BHY08_08835	COG1263	PTS System
BHY08_08835	COG2190	(PTS) system
BHY08_08835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_08845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BHY08_08860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BHY08_08865	COG0222	ribosome binding
BHY08_08870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BHY08_08875	COG0081	regulation of translation
BHY08_08890	COG2217	Heavy metal translocating P-type atpase
BHY08_08895	COG0765	amino acid transport
BHY08_08905	COG0371	Dehydrogenase
BHY08_08920	COG0343	queuine tRNA-ribosyltransferase activity
BHY08_08925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BHY08_08930	COG2255	four-way junction helicase activity
BHY08_08935	COG0632	four-way junction helicase activity
BHY08_08940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHY08_08945	COG0424	maF-like protein
BHY08_08950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BHY08_08955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BHY08_08965	COG1692	metallophosphoesterase
BHY08_08980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BHY08_09005	COG2814	Major facilitator Superfamily
BHY08_09010	COG1490	D-aminoacyl-tRNA deacylase activity
BHY08_09015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BHY08_09020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BHY08_09025	COG2264	protein methyltransferase activity
BHY08_09035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BHY08_09045	COG0589	response to stress
BHY08_09050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BHY08_09055	COG0827	DNA restriction-modification system
BHY08_09080	COG4537	Required for transformation and DNA binding
BHY08_09090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHY08_09095	COG0217	transcriptional regulatory protein
BHY08_09110	COG4708	membrane
BHY08_09115	COG1028	Short-chain dehydrogenase reductase Sdr
BHY08_09130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BHY08_09145	COG2813	Specifically methylates the guanine in position
BHY08_09160	COG1072	(Pantothenic acid kinase))
BHY08_09165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BHY08_09165	COG0519	Catalyzes the synthesis of GMP from XMP
BHY08_09205	COG2723	6-phospho-beta-galactosidase activity
BHY08_09210	COG1263	PTS System
BHY08_09210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_09210	COG2190	(PTS) system
BHY08_09215	COG3711	transcriptional antiterminator
BHY08_09225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_09230	COG0513	Belongs to the DEAD box helicase family
BHY08_09235	COG0673	inositol 2-dehydrogenase activity
BHY08_09240	COG1132	(ABC) transporter
BHY08_09260	COG2153	protein acetylation
BHY08_09265	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BHY08_09270	COG1278	Cold shock
BHY08_09275	COG2003	Belongs to the UPF0758 family
BHY08_09280	COG0546	phosphoglycolate phosphatase activity
BHY08_09285	COG0285	dihydrofolate synthase activity
BHY08_09290	COG0525	valine-tRNA ligase activity
BHY08_09295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BHY08_09300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BHY08_09330	COG1045	serine acetyltransferase
BHY08_09340	COG4862	establishment of competence for transformation
BHY08_09345	COG1393	Belongs to the ArsC family
BHY08_09350	COG0180	Tryptophanyl-tRNA synthetase
BHY08_09355	COG0740	serine-type endopeptidase activity
BHY08_09360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BHY08_09365	COG4466	Protein conserved in bacteria
BHY08_09375	COG0789	Transcriptional regulator
BHY08_09380	COG2814	Major facilitator Superfamily
BHY08_09395	COG3688	RNA-binding protein containing a PIN domain
BHY08_09400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHY08_09405	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BHY08_09410	COG0215	cysteine-tRNA ligase activity
BHY08_09415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHY08_09420	COG4956	integral membrane protein (PIN domain superfamily)
BHY08_09430	COG0756	dUTP diphosphatase activity
BHY08_09435	COG3158	transport of potassium into the cell
BHY08_09440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BHY08_09445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BHY08_09465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BHY08_09480	COG0110	maltose O-acetyltransferase activity
BHY08_09485	COG0436	Aminotransferase
BHY08_09495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BHY08_09510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BHY08_09515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHY08_09520	COG0527	aspartate kinase activity
BHY08_09535	COG0351	phosphomethylpyrimidine kinase
BHY08_09540	COG0352	thiamine-phosphate diphosphorylase activity
BHY08_09545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BHY08_09555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BHY08_09565	COG1129	ABC transporter
BHY08_09585	COG1285	pathogenesis
BHY08_09675	COG1660	Displays ATPase and GTPase activities
BHY08_09680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BHY08_09715	COG0066	3-isopropylmalate dehydratase activity
BHY08_09725	COG0473	3-isopropylmalate dehydrogenase activity
BHY08_09730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BHY08_09735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BHY08_09740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BHY08_09745	COG0440	acetolactate synthase activity
BHY08_09750	COG0028	Belongs to the TPP enzyme family
BHY08_09755	COG0129	dihydroxy-acid dehydratase activity
BHY08_09775	COG1902	pentaerythritol trinitrate reductase activity
BHY08_09790	COG0519	Catalyzes the synthesis of GMP from XMP
BHY08_09805	COG1132	(ABC) transporter
BHY08_09820	COG0420	3'-5' exonuclease activity
BHY08_09825	COG0204	Acyl-transferase
BHY08_09830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BHY08_09835	COG2827	Endonuclease containing a URI domain
BHY08_09865	COG1447	Phosphotransferase system cellobiose-specific component IIA
BHY08_09870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BHY08_09885	COG3579	cysteine-type endopeptidase activity
BHY08_09895	COG1914	H( )-stimulated, divalent metal cation uptake system
BHY08_09900	COG2271	Major facilitator Superfamily
BHY08_09905	COG1473	amidohydrolase
BHY08_09910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_09910	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_09915	COG3716	PTS system mannose fructose sorbose family IID component
BHY08_09920	COG3715	PTS system
BHY08_09935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHY08_09945	COG1304	FMN binding
BHY08_09950	COG1346	cytolysis
BHY08_10020	COG0583	DNA-binding transcription factor activity
BHY08_10025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BHY08_10030	COG0400	carboxylic ester hydrolase activity
BHY08_10035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BHY08_10040	COG0346	lactoylglutathione lyase activity
BHY08_10045	COG0346	lactoylglutathione lyase activity
BHY08_10050	COG1846	Transcriptional regulator
BHY08_10075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BHY08_10080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BHY08_10085	COG0101	tRNA pseudouridine synthase activity
BHY08_10095	COG1122	ATPase activity
BHY08_10100	COG1122	ATPase activity
BHY08_10105	COG0203	ribosomal protein L17
BHY08_10110	COG0202	RNA polymerase activity
BHY08_10115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BHY08_10120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BHY08_10125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BHY08_10130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BHY08_10135	COG0563	adenylate kinase activity
BHY08_10150	COG1841	ribosomal large subunit assembly
BHY08_10155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BHY08_10170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BHY08_10175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BHY08_10180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BHY08_10185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BHY08_10190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BHY08_10195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BHY08_10200	COG0255	Belongs to the universal ribosomal protein uL29 family
BHY08_10205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BHY08_10210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BHY08_10215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BHY08_10225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BHY08_10230	COG0089	rRNA binding
BHY08_10235	COG0088	Forms part of the polypeptide exit tunnel
BHY08_10240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BHY08_10245	COG0051	transcription antitermination factor activity, RNA binding
BHY08_10250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHY08_10255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BHY08_10260	COG0049	tRNA binding
BHY08_10265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BHY08_10270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BHY08_10275	COG0588	phosphoglycerate mutase activity
BHY08_10280	COG1114	Component of the transport system for branched-chain amino acids
BHY08_10470	COG1686	Belongs to the peptidase S11 family
BHY08_10475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BHY08_10485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BHY08_10500	COG0012	GTP binding
BHY08_10505	COG4481	Protein conserved in bacteria
BHY08_10515	COG1192	Involved in chromosome partitioning
BHY08_10520	COG0357	Ribosomal RNA small subunit methyltransferase G
BHY08_10530	COG0445	tRNA wobble uridine modification
BHY08_10535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BHY08_10540	COG4166	transmembrane transport
BHY08_10545	COG1847	R3H domain protein
BHY08_10550	COG0706	membrane insertase activity
BHY08_10555	COG0594	ribonuclease P activity
BHY08_10560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BHY08_10580	COG3620	sequence-specific DNA binding
BHY08_10595	COG0656	L-ascorbic acid biosynthetic process
BHY08_10600	COG0789	Transcriptional regulator
BHY08_10605	COG3316	Transposase and inactivated derivatives
BHY08_10610	COG2217	Heavy metal translocating P-type atpase