locus-tag	class	description
HYG85_00025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYG85_00040	COG1496	oxidoreductase activity
HYG85_00045	COG0792	nuclease activity
HYG85_00050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG85_00060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYG85_00070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HYG85_00075	COG0681	Belongs to the peptidase S26 family
HYG85_00080	COG0335	large ribosomal subunit rRNA binding
HYG85_00085	COG0336	Belongs to the RNA methyltransferase TrmD family
HYG85_00090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYG85_00100	COG0228	four-way junction DNA binding
HYG85_00105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYG85_00115	COG0552	protein localization to endoplasmic reticulum
HYG85_00120	COG1196	nuclear chromosome segregation
HYG85_00125	COG0571	ribonuclease III activity
HYG85_00130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_00135	COG0416	fatty acid biosynthetic process
HYG85_00140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYG85_00155	COG0280	phosphate acetyltransferase
HYG85_00160	COG1323	Belongs to the UPF0348 family
HYG85_00175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYG85_00180	COG0742	ribosomal rna small subunit methyltransferase
HYG85_00190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYG85_00195	COG1461	Dihydroxyacetone kinase
HYG85_00200	COG1302	Protein conserved in bacteria
HYG85_00205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYG85_00215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYG85_00220	COG1162	GTPase activity
HYG85_00225	COG0515	serine threonine protein kinase
HYG85_00225	COG2815	serine threonine protein kinase
HYG85_00235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG85_00240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG85_00240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG85_00245	COG2738	Putative neutral zinc metallopeptidase
HYG85_00250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYG85_00255	COG0242	peptide deformylase activity
HYG85_00260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYG85_00265	COG1758	RNA polymerase activity
HYG85_00270	COG0194	GDP metabolic process
HYG85_00275	COG2052	Domain of unknown function (DUF370)
HYG85_00280	COG1561	YicC-like family, N-terminal region
HYG85_00300	COG0395	ABC-type sugar transport system, permease component
HYG85_00310	COG1653	transport
HYG85_00315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG85_00315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG85_00320	COG0372	Belongs to the citrate synthase family
HYG85_00340	COG2746	aminoglycoside 3-N-acetyltransferase activity
HYG85_00345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYG85_00350	COG0154	amidase activity
HYG85_00360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYG85_00380	COG0217	transcriptional regulatory protein
HYG85_00385	COG0534	Mate efflux family protein
HYG85_00395	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYG85_00400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYG85_00405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYG85_00405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYG85_00410	COG0736	holo-[acyl-carrier-protein] synthase activity
HYG85_00420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYG85_00430	COG0488	(ABC) transporter
HYG85_00435	COG1802	Transcriptional regulator
HYG85_00440	COG0473	3-isopropylmalate dehydrogenase activity
HYG85_00445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYG85_00460	COG1404	Belongs to the peptidase S8 family
HYG85_00485	COG3328	transposase activity
HYG85_00490	COG0495	leucyl-tRNA aminoacylation
HYG85_00525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG85_00530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG85_00535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYG85_00540	COG0287	Prephenate dehydrogenase
HYG85_00560	COG0205	6-phosphofructokinase activity
HYG85_00565	COG0402	S-adenosylhomocysteine deaminase activity
HYG85_00570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG85_00575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HYG85_00580	COG3842	ATPase activity
HYG85_00585	COG1177	transmembrane transport
HYG85_00590	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYG85_00605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYG85_00610	COG3842	ATPase activity
HYG85_00615	COG1177	transmembrane transport
HYG85_00620	COG1840	ABC-type Fe3 transport system, periplasmic component
HYG85_00625	COG0542	response to heat
HYG85_00645	COG3409	Peptidoglycan-binding domain 1 protein
HYG85_00645	COG3773	Cell wall hydrolase
HYG85_00655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG85_00700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG85_00705	COG0697	spore germination
HYG85_00725	COG0745	RESPONSE REGULATOR receiver
HYG85_00730	COG5002	protein histidine kinase activity
HYG85_00730	COG3850	Histidine kinase
HYG85_00735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG85_00740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYG85_00750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYG85_00755	COG0358	DNA primase activity
HYG85_00760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYG85_00775	COG4399	Belongs to the UPF0754 family
HYG85_00780	COG0574	Belongs to the PEP-utilizing enzyme family
HYG85_00780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG85_00785	COG0423	glycine-tRNA ligase activity
HYG85_00795	COG1381	Involved in DNA repair and RecF pathway recombination
HYG85_00800	COG0577	efflux transmembrane transporter activity
HYG85_00810	COG1136	(ABC) transporter
HYG85_00815	COG3547	Transposase (IS116 IS110 IS902 family)
HYG85_00820	COG5002	protein histidine kinase activity
HYG85_00820	COG0642	Histidine kinase
HYG85_00835	COG0840	transmembrane signaling receptor activity
HYG85_00840	COG0840	transmembrane signaling receptor activity
HYG85_00870	COG1904	glucuronate isomerase
HYG85_00875	COG1609	Transcriptional regulator
HYG85_00885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYG85_00895	COG1956	GAF domain-containing protein
HYG85_00900	COG4555	ABC transporter
HYG85_00915	COG1278	Cold shock
HYG85_00930	COG0138	bifunctional purine biosynthesis protein purh
HYG85_00950	COG1196	nuclear chromosome segregation
HYG85_00990	COG4974	Belongs to the 'phage' integrase family
HYG85_01015	COG0519	Catalyzes the synthesis of GMP from XMP
HYG85_01035	COG1609	Transcriptional regulator
HYG85_01040	COG1554	hydrolase, family 65, central catalytic
HYG85_01045	COG5002	protein histidine kinase activity
HYG85_01050	COG0745	RESPONSE REGULATOR receiver
HYG85_01055	COG0704	Plays a role in the regulation of phosphate uptake
HYG85_01060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG85_01065	COG0581	inorganic phosphate transmembrane transporter activity
HYG85_01070	COG0573	inorganic phosphate transmembrane transporter activity
HYG85_01075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYG85_01080	COG0516	GMP reductase activity
HYG85_01080	COG0517	IMP dehydrogenase activity
HYG85_01090	COG0459	protein refolding
HYG85_01095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYG85_01145	COG3688	RNA-binding protein containing a PIN domain
HYG85_01150	COG3250	beta-galactosidase activity
HYG85_01155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG85_01160	COG2244	polysaccharide biosynthetic process
HYG85_01170	COG0215	cysteine-tRNA ligase activity
HYG85_01175	COG1045	serine acetyltransferase
HYG85_01185	COG3119	arylsulfatase activity
HYG85_01195	COG1342	Belongs to the UPF0251 family
HYG85_01210	COG3250	beta-galactosidase activity
HYG85_01225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYG85_01230	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HYG85_01240	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG85_01260	COG2212	antiporter activity
HYG85_01265	COG1320	monovalent cation:proton antiporter activity
HYG85_01280	COG2111	Na H antiporter
HYG85_01285	COG1006	Multisubunit Na H antiporter MnhC subunit
HYG85_01290	COG0651	ATP synthesis coupled electron transport
HYG85_01295	COG2323	membrane
HYG85_01305	COG4608	Belongs to the ABC transporter superfamily
HYG85_01310	COG0444	Belongs to the ABC transporter superfamily
HYG85_01315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG85_01320	COG0601	transmembrane transport
HYG85_01325	COG4166	transmembrane transport
HYG85_01365	COG3773	Cell wall hydrolase
HYG85_01370	COG0398	Pfam SNARE associated Golgi protein
HYG85_01380	COG0513	Belongs to the DEAD box helicase family
HYG85_01410	COG1131	(ABC) transporter
HYG85_01415	COG1309	transcriptional regulator
HYG85_01420	COG1012	belongs to the aldehyde dehydrogenase family
HYG85_01425	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_01430	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HYG85_01435	COG1414	Transcriptional regulator
HYG85_01440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYG85_01515	COG0457	Tetratricopeptide repeat
HYG85_01520	COG2207	Transcriptional regulator
HYG85_01525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYG85_01555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYG85_01565	COG3623	hexulose-6-phosphate isomerase
HYG85_01575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYG85_01580	COG2996	Protein conserved in bacteria
HYG85_01585	COG0488	(ABC) transporter
HYG85_01600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HYG85_01630	COG2894	cell division
HYG85_01635	COG0489	protein tyrosine kinase activity
HYG85_01645	COG0813	purine-nucleoside phosphorylase activity
HYG85_01655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYG85_01680	COG3547	Transposase (IS116 IS110 IS902 family)
HYG85_01685	COG0395	ABC-type sugar transport system, permease component
HYG85_01690	COG1175	transmembrane transport
HYG85_01700	COG3275	phosphorelay sensor kinase activity
HYG85_01705	COG2207	Transcriptional regulator
HYG85_01705	COG4753	response regulator
HYG85_01750	COG0395	ABC-type sugar transport system, permease component
HYG85_01755	COG1175	transmembrane transport
HYG85_01765	COG2207	Transcriptional regulator
HYG85_01765	COG4753	response regulator
HYG85_01770	COG2972	Histidine kinase
HYG85_01775	COG1653	transport
HYG85_01825	COG1595	DNA-templated transcription, initiation
HYG85_01930	COG0395	ABC-type sugar transport system, permease component
HYG85_01935	COG1175	transmembrane transport
HYG85_01945	COG4753	response regulator
HYG85_01945	COG2207	Transcriptional regulator
HYG85_01950	COG2972	Histidine kinase
HYG85_01980	COG2132	Multicopper oxidase
HYG85_01995	COG1595	DNA-templated transcription, initiation
HYG85_02015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_02025	COG2340	Cysteine-rich secretory protein family
HYG85_02065	COG0281	malic enzyme
HYG85_02070	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HYG85_02075	COG1757	Na H antiporter
HYG85_02085	COG0840	transmembrane signaling receptor activity
HYG85_02120	COG0673	inositol 2-dehydrogenase activity
HYG85_02150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG85_02155	COG0641	radical SAM
HYG85_02255	COG3546	catalase activity
HYG85_02265	COG0737	Belongs to the 5'-nucleotidase family
HYG85_02285	COG0584	glycerophosphoryl diester phosphodiesterase
HYG85_02290	COG1116	anion transmembrane transporter activity
HYG85_02305	COG0191	fructose-bisphosphate aldolase activity
HYG85_02320	COG0493	'glutamate synthase
HYG85_02320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG85_02335	COG0534	Mate efflux family protein
HYG85_02370	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HYG85_02390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYG85_02395	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYG85_02425	COG1842	Phage shock protein A
HYG85_02445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYG85_02450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYG85_02455	COG1121	(ABC) transporter
HYG85_02460	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYG85_02475	COG0312	modulator of DNA gyrase
HYG85_02480	COG0312	modulator of DNA gyrase
HYG85_02490	COG2199	diguanylate cyclase activity
HYG85_02525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYG85_02530	COG3850	Histidine kinase
HYG85_02530	COG5002	protein histidine kinase activity
HYG85_02535	COG0745	RESPONSE REGULATOR receiver
HYG85_02545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG85_02555	COG0432	Pfam Uncharacterised protein family UPF0047
HYG85_02585	COG1796	DNA polymerase
HYG85_02585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG85_02590	COG2135	peptidase activity
HYG85_02605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYG85_02610	COG0390	transport system, permease component
HYG85_02615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG85_02620	COG1695	Transcriptional regulator
HYG85_02635	COG0395	ABC-type sugar transport system, permease component
HYG85_02640	COG1175	transmembrane transport
HYG85_02650	COG1609	Transcriptional regulator
HYG85_02675	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG85_02690	COG0488	(ABC) transporter
HYG85_02695	COG2610	gluconate transmembrane transporter activity
HYG85_02700	COG1929	Belongs to the glycerate kinase type-1 family
HYG85_02705	COG3835	regulator
HYG85_02715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG85_02740	COG0745	RESPONSE REGULATOR receiver
HYG85_02745	COG5002	protein histidine kinase activity
HYG85_02750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG85_02760	COG2132	Multicopper oxidase
HYG85_02800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG85_02815	COG1070	Carbohydrate kinase
HYG85_02820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG85_02825	COG1882	Formate acetyltransferase
HYG85_02830	COG1609	Transcriptional regulator
HYG85_02850	COG3328	transposase activity
HYG85_02880	COG3344	reverse transcriptase
HYG85_02885	COG3344	reverse transcriptase
HYG85_02890	COG3328	transposase activity
HYG85_02905	COG1309	transcriptional regulator
HYG85_02930	COG1342	Belongs to the UPF0251 family
HYG85_02950	COG0735	belongs to the Fur family
HYG85_02955	COG0719	Fe-S assembly protein
HYG85_02960	COG0396	ATPase activity
HYG85_02985	COG0450	alkyl hydroperoxide reductase
HYG85_03005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG85_03015	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HYG85_03020	COG2207	Transcriptional regulator
HYG85_03025	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYG85_03030	COG0789	Transcriptional regulator
HYG85_03040	COG1132	(ABC) transporter
HYG85_03045	COG1132	(ABC) transporter
HYG85_03050	COG1846	Transcriptional regulator
HYG85_03060	COG2217	Heavy metal translocating P-type atpase
HYG85_03070	COG2045	Belongs to the ComB family
HYG85_03095	COG1132	(ABC) transporter
HYG85_03100	COG1132	(ABC) transporter
HYG85_03105	COG0534	Mate efflux family protein
HYG85_03115	COG3547	Transposase (IS116 IS110 IS902 family)
HYG85_03125	COG4608	Belongs to the ABC transporter superfamily
HYG85_03130	COG0444	Belongs to the ABC transporter superfamily
HYG85_03135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG85_03140	COG0601	transmembrane transport
HYG85_03155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG85_03180	COG0840	transmembrane signaling receptor activity
HYG85_03200	COG3842	ATPase activity
HYG85_03210	COG0673	inositol 2-dehydrogenase activity
HYG85_03215	COG1082	Xylose isomerase domain protein TIM barrel
HYG85_03225	COG0673	inositol 2-dehydrogenase activity
HYG85_03230	COG1609	Transcriptional regulator
HYG85_03260	COG2373	Large extracellular alpha-helical protein
HYG85_03265	COG1361	Conserved repeat domain
HYG85_03275	COG0747	negative chemotaxis
HYG85_03280	COG4608	Belongs to the ABC transporter superfamily
HYG85_03295	COG0601	transmembrane transport
HYG85_03300	COG1132	(ABC) transporter
HYG85_03310	COG1609	Transcriptional regulator
HYG85_03310	COG2207	Transcriptional regulator
HYG85_03315	COG2186	Transcriptional regulator
HYG85_03325	COG1346	cytolysis
HYG85_03340	COG2207	Transcriptional regulator
HYG85_03345	COG0352	thiamine-phosphate diphosphorylase activity
HYG85_03355	COG2022	thiamine diphosphate biosynthetic process
HYG85_03370	COG1132	(ABC) transporter
HYG85_03375	COG1132	(ABC) transporter
HYG85_03385	COG1501	Belongs to the glycosyl hydrolase 31 family
HYG85_03395	COG0395	ABC-type sugar transport system, permease component
HYG85_03400	COG4209	transmembrane transport
HYG85_03410	COG1129	ABC transporter
HYG85_03425	COG1132	(ABC) transporter
HYG85_03430	COG1132	(ABC) transporter
HYG85_03440	COG1129	ABC transporter
HYG85_03460	COG2378	regulation of single-species biofilm formation
HYG85_03470	COG1063	alcohol dehydrogenase
HYG85_03475	COG1309	transcriptional regulator
HYG85_03485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYG85_03500	COG1979	alcohol dehydrogenase
HYG85_03505	COG1349	DNA-binding transcription factor activity
HYG85_03510	COG2226	methyltransferase
HYG85_03540	COG3682	Transcriptional regulator
HYG85_03555	COG2378	regulation of single-species biofilm formation
HYG85_03560	COG0488	(ABC) transporter
HYG85_03580	COG0701	Predicted permease
HYG85_03590	COG3901	Regulator of nitric oxide reductase transcription
HYG85_03590	COG0348	domain, Protein
HYG85_03595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYG85_03605	COG1132	(ABC) transporter
HYG85_03610	COG4988	ABC transporter
HYG85_03615	COG2832	Protein of unknown function (DUF454)
HYG85_03620	COG4977	sequence-specific DNA binding
HYG85_03620	COG1917	Cupin 2, conserved barrel domain protein
HYG85_03625	COG1349	DNA-binding transcription factor activity
HYG85_03630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYG85_03660	COG1166	arginine decarboxylase activity
HYG85_03670	COG0348	domain, Protein
HYG85_03670	COG3901	Regulator of nitric oxide reductase transcription
HYG85_03690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG85_03705	COG1129	ABC transporter
HYG85_03725	COG1132	(ABC) transporter
HYG85_03730	COG2375	cellular response to nickel ion
HYG85_03730	COG1132	(ABC) transporter
HYG85_03760	COG3135	benzoate transporter
HYG85_03790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_03815	COG0745	RESPONSE REGULATOR receiver
HYG85_03840	COG2207	Transcriptional regulator
HYG85_03840	COG3708	Transcriptional regulator
HYG85_03850	COG1132	(ABC) transporter
HYG85_03910	COG0697	spore germination
HYG85_03925	COG1131	(ABC) transporter
HYG85_03930	COG1061	Type III restriction enzyme res subunit
HYG85_03955	COG1051	belongs to the nudix hydrolase family
HYG85_03955	COG1056	cytidyltransferase-related domain
HYG85_03985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYG85_03990	COG4608	Belongs to the ABC transporter superfamily
HYG85_03995	COG0444	Belongs to the ABC transporter superfamily
HYG85_04000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG85_04060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYG85_04070	COG1917	Cupin 2, conserved barrel domain protein
HYG85_04070	COG2207	Transcriptional regulator
HYG85_04085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYG85_04090	COG1396	sequence-specific DNA binding
HYG85_04105	COG3409	Peptidoglycan-binding domain 1 protein
HYG85_04105	COG5632	N-Acetylmuramoyl-L-alanine amidase
HYG85_04160	COG1846	Transcriptional regulator
HYG85_04175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYG85_04180	COG0569	domain protein
HYG85_04185	COG0569	domain protein
HYG85_04195	COG0745	RESPONSE REGULATOR receiver
HYG85_04200	COG2205	protein histidine kinase activity
HYG85_04220	COG0210	DNA helicase
HYG85_04230	COG4496	protein, YerC YecD
HYG85_04235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG85_04250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYG85_04265	COG0840	transmembrane signaling receptor activity
HYG85_04270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYG85_04280	COG1966	Carbon starvation protein
HYG85_04285	COG3279	Response regulator of the LytR AlgR family
HYG85_04315	COG1116	anion transmembrane transporter activity
HYG85_04320	COG0681	Belongs to the peptidase S26 family
HYG85_04325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYG85_04335	COG1349	DNA-binding transcription factor activity
HYG85_04340	COG3395	kinase activity
HYG85_04345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYG85_04350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HYG85_04355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYG85_04360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYG85_04360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYG85_04375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG85_04385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG85_04395	COG1362	aminopeptidase activity
HYG85_04400	COG2094	Belongs to the DNA glycosylase MPG family
HYG85_04415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG85_04420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYG85_04435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG85_04515	COG3266	domain, Protein
HYG85_04515	COG1361	Conserved repeat domain
HYG85_04515	COG2911	Protein conserved in bacteria
HYG85_04620	COG5484	DNA packaging
HYG85_04625	COG4974	Belongs to the 'phage' integrase family
HYG85_04730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG85_04735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG85_04755	COG3835	regulator
HYG85_04760	COG2610	gluconate transmembrane transporter activity
HYG85_04770	COG1396	sequence-specific DNA binding
HYG85_04775	COG3620	sequence-specific DNA binding
HYG85_04785	COG4154	Belongs to the RbsD FucU family
HYG85_04790	COG1105	Belongs to the carbohydrate kinase PfkB family
HYG85_04800	COG1063	alcohol dehydrogenase
HYG85_04805	COG0656	L-ascorbic acid biosynthetic process
HYG85_04815	COG1846	Transcriptional regulator
HYG85_04825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG85_04830	COG0095	Lipoate-protein ligase
HYG85_04835	COG3119	arylsulfatase activity
HYG85_04860	COG1396	sequence-specific DNA binding
HYG85_04935	COG1396	sequence-specific DNA binding
HYG85_04970	COG3547	Transposase (IS116 IS110 IS902 family)
HYG85_04985	COG0726	polysaccharide deacetylase
HYG85_05000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG85_05010	COG0697	spore germination
HYG85_05020	COG0656	L-ascorbic acid biosynthetic process
HYG85_05040	COG1592	Rubrerythrin
HYG85_05045	COG2033	superoxide reductase activity
HYG85_05050	COG1739	Uncharacterized protein family UPF0029
HYG85_05055	COG0095	Lipoate-protein ligase
HYG85_05060	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG85_05065	COG2207	Transcriptional regulator
HYG85_05065	COG1917	Cupin 2, conserved barrel domain protein
HYG85_05095	COG0183	Belongs to the thiolase family
HYG85_05110	COG0191	fructose-bisphosphate aldolase activity
HYG85_05115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_05120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_05125	COG1129	ABC transporter
HYG85_05140	COG1082	Xylose isomerase domain protein TIM barrel
HYG85_05150	COG1082	Xylose isomerase domain protein TIM barrel
HYG85_05155	COG0673	inositol 2-dehydrogenase activity
HYG85_05160	COG1349	DNA-binding transcription factor activity
HYG85_05165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG85_05175	COG0395	ABC-type sugar transport system, permease component
HYG85_05180	COG1175	transmembrane transport
HYG85_05195	COG2207	Transcriptional regulator
HYG85_05195	COG4753	response regulator
HYG85_05205	COG5012	cobalamin binding
HYG85_05210	COG5012	cobalamin binding
HYG85_05225	COG0523	cobalamin synthesis protein
HYG85_05245	COG0436	Aminotransferase
HYG85_05250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYG85_05265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYG85_05270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYG85_05280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG85_05305	COG1191	sigma factor activity
HYG85_05310	COG2172	sigma factor antagonist activity
HYG85_05315	COG1366	Belongs to the anti-sigma-factor antagonist family
HYG85_05330	COG0285	dihydrofolate synthase activity
HYG85_05365	COG0697	spore germination
HYG85_05370	COG0531	amino acid
HYG85_05390	COG1486	melibiose metabolic process
HYG85_05395	COG2207	Transcriptional regulator
HYG85_05405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYG85_05410	COG0167	dihydroorotate dehydrogenase activity
HYG85_05415	COG0543	2 iron, 2 sulfur cluster binding
HYG85_05430	COG0284	orotidine-5'-phosphate decarboxylase activity
HYG85_05435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYG85_05440	COG0517	IMP dehydrogenase activity
HYG85_05455	COG0475	glutathione-regulated potassium exporter activity
HYG85_05460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYG85_05465	COG2890	protein-(glutamine-N5) methyltransferase activity
HYG85_05470	COG3872	metal-dependent enzyme
HYG85_05475	COG0254	rRNA binding
HYG85_05480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYG85_05490	COG2239	Acts as a magnesium transporter
HYG85_05510	COG1307	EDD domain protein, DegV family
HYG85_05540	COG1131	(ABC) transporter
HYG85_05545	COG2855	membrane
HYG85_05550	COG0583	DNA-binding transcription factor activity
HYG85_05565	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HYG85_05590	COG1132	(ABC) transporter
HYG85_05600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYG85_05600	COG3321	synthase
HYG85_05600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYG85_05600	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_05600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_05630	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYG85_05635	COG2192	nodulation
HYG85_05640	COG2192	nodulation
HYG85_05645	COG2192	nodulation
HYG85_05650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG85_05655	COG2086	electron transfer activity
HYG85_05660	COG1960	acyl-CoA dehydrogenase activity
HYG85_05670	COG3541	Predicted nucleotidyltransferase
HYG85_05695	COG2197	response regulator
HYG85_05715	COG0789	Transcriptional regulator
HYG85_05720	COG1454	alcohol dehydrogenase
HYG85_05730	COG1131	(ABC) transporter
HYG85_05745	COG0242	peptide deformylase activity
HYG85_05750	COG3321	synthase
HYG85_05750	COG0300	oxidoreductase activity
HYG85_05750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_05750	COG4221	oxidoreductase activity
HYG85_05755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYG85_05755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYG85_05755	COG3321	synthase
HYG85_05755	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_05755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_05760	COG1024	Enoyl-CoA hydratase
HYG85_05765	COG3425	synthase
HYG85_05770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYG85_05775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_05780	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_05780	COG3321	synthase
HYG85_05780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYG85_05780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYG85_05780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_05795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYG85_05795	COG2070	2-Nitropropane dioxygenase
HYG85_05815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG85_05825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYG85_05830	COG0439	Biotin carboxylase
HYG85_05840	COG1073	alpha beta
HYG85_05845	COG5002	protein histidine kinase activity
HYG85_05850	COG0745	RESPONSE REGULATOR receiver
HYG85_05860	COG1309	transcriptional regulator
HYG85_05885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYG85_05895	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HYG85_05925	COG0384	phenazine biosynthesis protein PhzF
HYG85_05985	COG0622	Phosphoesterase
HYG85_06060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYG85_06120	COG3708	Transcriptional regulator
HYG85_06120	COG2207	Transcriptional regulator
HYG85_06130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYG85_06150	COG0500	methyltransferase
HYG85_06155	COG2207	Transcriptional regulator
HYG85_06155	COG3708	Transcriptional regulator
HYG85_06160	COG4106	trans-aconitate 2-methyltransferase activity
HYG85_06220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG85_06335	COG3547	Transposase (IS116 IS110 IS902 family)
HYG85_06375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYG85_06395	COG0494	nUDIX hydrolase
HYG85_06400	COG0406	alpha-ribazole phosphatase activity
HYG85_06425	COG4974	Belongs to the 'phage' integrase family
HYG85_06440	COG1312	Catalyzes the dehydration of D-mannonate
HYG85_06450	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_06455	COG0006	proline dipeptidase activity
HYG85_06460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYG85_06465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_06470	COG1129	ABC transporter
HYG85_06480	COG1609	Transcriptional regulator
HYG85_06495	COG0840	transmembrane signaling receptor activity
HYG85_06505	COG0659	secondary active sulfate transmembrane transporter activity
HYG85_06515	COG2199	diguanylate cyclase activity
HYG85_06515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG85_06520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYG85_06525	COG0640	Transcriptional regulator
HYG85_06530	COG5658	integral membrane protein
HYG85_06540	COG1242	4 iron, 4 sulfur cluster binding
HYG85_06550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYG85_06555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYG85_06560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYG85_06565	COG0740	serine-type endopeptidase activity
HYG85_06570	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYG85_06585	COG4608	Belongs to the ABC transporter superfamily
HYG85_06590	COG0444	Belongs to the ABC transporter superfamily
HYG85_06595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG85_06600	COG0601	transmembrane transport
HYG85_06605	COG4166	transmembrane transport
HYG85_06665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYG85_06705	COG0116	Belongs to the methyltransferase superfamily
HYG85_06715	COG0622	Phosphoesterase
HYG85_06730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYG85_06740	COG2339	peptidase activity
HYG85_06780	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HYG85_06785	COG4869	propanediol catabolic process
HYG85_06795	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HYG85_06810	COG1063	alcohol dehydrogenase
HYG85_06855	COG1349	DNA-binding transcription factor activity
HYG85_06875	COG2190	(PTS) system
HYG85_06875	COG2211	Major facilitator Superfamily
HYG85_06900	COG1609	Transcriptional regulator
HYG85_06900	COG2207	Transcriptional regulator
HYG85_06930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG85_06935	COG1069	ribulokinase activity
HYG85_06945	COG3250	beta-galactosidase activity
HYG85_06955	COG1653	transport
HYG85_06960	COG0395	ABC-type sugar transport system, permease component
HYG85_06965	COG4209	transmembrane transport
HYG85_06970	COG2972	Histidine kinase
HYG85_06975	COG2207	Transcriptional regulator
HYG85_06975	COG4753	response regulator
HYG85_06985	COG3507	Belongs to the glycosyl hydrolase 43 family
HYG85_07000	COG4175	Glycine betaine
HYG85_07000	COG0517	IMP dehydrogenase activity
HYG85_07015	COG1609	Transcriptional regulator
HYG85_07015	COG2207	Transcriptional regulator
HYG85_07020	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYG85_07040	COG1131	(ABC) transporter
HYG85_07050	COG1595	DNA-templated transcription, initiation
HYG85_07055	COG3344	reverse transcriptase
HYG85_07080	COG3681	Belongs to the UPF0597 family
HYG85_07090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYG85_07100	COG1301	dicarboxylic acid transport
HYG85_07105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG85_07120	COG1151	hydroxylamine reductase activity
HYG85_07130	COG0006	proline dipeptidase activity
HYG85_07140	COG1785	Belongs to the alkaline phosphatase family
HYG85_07165	COG0363	glucosamine-6-phosphate deaminase activity
HYG85_07175	COG4821	SIS domain
HYG85_07225	COG1476	TRANSCRIPTIONal
HYG85_07280	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG85_07285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG85_07290	COG0395	ABC-type sugar transport system, permease component
HYG85_07295	COG1175	transmembrane transport
HYG85_07305	COG2207	Transcriptional regulator
HYG85_07305	COG4753	response regulator
HYG85_07310	COG2972	Histidine kinase
HYG85_07320	COG1879	ABC-type sugar transport system periplasmic component
HYG85_07325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_07330	COG1129	ABC transporter
HYG85_07335	COG1869	D-ribose catabolic process
HYG85_07340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_07345	COG1609	Transcriptional regulator
HYG85_07360	COG1012	belongs to the aldehyde dehydrogenase family
HYG85_07375	COG1136	(ABC) transporter
HYG85_07400	COG0840	transmembrane signaling receptor activity
HYG85_07400	COG5278	phosphoserine phosphatase activity
HYG85_07410	COG2207	Transcriptional regulator
HYG85_07410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG85_07415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG85_07415	COG2207	Transcriptional regulator
HYG85_07450	COG3279	Response regulator of the LytR AlgR family
HYG85_07480	COG1690	Belongs to the RtcB family
HYG85_07490	COG1470	cell adhesion involved in biofilm formation
HYG85_07490	COG0366	Alpha amylase catalytic
HYG85_07495	COG3833	ABC-type maltose transport systems, permease component
HYG85_07500	COG1175	transmembrane transport
HYG85_07505	COG1653	transport
HYG85_07510	COG2207	Transcriptional regulator
HYG85_07515	COG2972	Histidine kinase
HYG85_07530	COG1115	amino acid carrier protein
HYG85_07580	COG0745	RESPONSE REGULATOR receiver
HYG85_07585	COG2205	protein histidine kinase activity
HYG85_07590	COG1136	(ABC) transporter
HYG85_07680	COG0395	ABC-type sugar transport system, permease component
HYG85_07695	COG0438	transferase activity, transferring glycosyl groups
HYG85_07700	COG1609	Transcriptional regulator
HYG85_07705	COG3266	domain, Protein
HYG85_07705	COG2911	Protein conserved in bacteria
HYG85_07705	COG1361	Conserved repeat domain
HYG85_07710	COG5002	protein histidine kinase activity
HYG85_07715	COG0745	RESPONSE REGULATOR receiver
HYG85_07735	COG2312	Erythromycin esterase
HYG85_07740	COG0534	Mate efflux family protein
HYG85_07815	COG0326	Molecular chaperone. Has ATPase activity
HYG85_07825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG85_07835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYG85_07855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYG85_07860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYG85_07875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYG85_07880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYG85_07900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HYG85_07900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HYG85_07905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYG85_07925	COG1309	transcriptional regulator
HYG85_07930	COG0534	Mate efflux family protein
HYG85_07935	COG4555	ABC transporter
HYG85_07945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HYG85_07975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG85_07980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG85_07985	COG1368	sulfuric ester hydrolase activity
HYG85_08015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG85_08020	COG0569	domain protein
HYG85_08025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYG85_08030	COG0426	domain, Protein
HYG85_08040	COG2188	Transcriptional regulator
HYG85_08045	COG1131	(ABC) transporter
HYG85_08055	COG0673	inositol 2-dehydrogenase activity
HYG85_08060	COG1082	Xylose isomerase domain protein TIM barrel
HYG85_08065	COG0673	inositol 2-dehydrogenase activity
HYG85_08070	COG1609	Transcriptional regulator
HYG85_08075	COG0395	ABC-type sugar transport system, permease component
HYG85_08095	COG0395	ABC-type sugar transport system, permease component
HYG85_08115	COG1917	Cupin 2, conserved barrel domain protein
HYG85_08115	COG2207	Transcriptional regulator
HYG85_08145	COG0840	transmembrane signaling receptor activity
HYG85_08150	COG2204	response regulator
HYG85_08160	COG2376	Dihydroxyacetone kinase
HYG85_08175	COG0411	ABC transporter
HYG85_08195	COG3681	Belongs to the UPF0597 family
HYG85_08200	COG0366	Alpha amylase catalytic
HYG85_08205	COG0395	ABC-type sugar transport system, permease component
HYG85_08210	COG4209	transmembrane transport
HYG85_08220	COG2207	Transcriptional regulator
HYG85_08225	COG2972	Histidine kinase
HYG85_08240	COG1940	carbohydrate kinase activity
HYG85_08250	COG0662	Cupin 2, conserved barrel domain protein
HYG85_08260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYG85_08265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYG85_08280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYG85_08290	COG1122	ATPase activity
HYG85_08295	COG0203	ribosomal protein L17
HYG85_08300	COG0202	RNA polymerase activity
HYG85_08305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYG85_08310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYG85_08315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYG85_08320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYG85_08325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYG85_08340	COG0563	adenylate kinase activity
HYG85_08350	COG0200	Binds to the 23S rRNA
HYG85_08355	COG1841	ribosomal large subunit assembly
HYG85_08360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYG85_08370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYG85_08375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYG85_08380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYG85_08385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYG85_08390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYG85_08400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYG85_08405	COG0255	Belongs to the universal ribosomal protein uL29 family
HYG85_08410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYG85_08420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYG85_08430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYG85_08445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYG85_08450	COG0051	transcription antitermination factor activity, RNA binding
HYG85_08455	COG3708	Transcriptional regulator
HYG85_08455	COG2207	Transcriptional regulator
HYG85_08460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG85_08465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG85_08470	COG0049	tRNA binding
HYG85_08475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYG85_08480	COG1358	cellular component organization or biogenesis
HYG85_08485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYG85_08490	COG0085	RNA polymerase activity
HYG85_08495	COG0222	ribosome binding
HYG85_08505	COG0081	regulation of translation
HYG85_08510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYG85_08515	COG0250	Participates in transcription elongation, termination and antitermination
HYG85_08525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYG85_08540	COG1516	flagellar protein fliS
HYG85_08545	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYG85_08565	COG0463	Glycosyl transferase, family 2
HYG85_08575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG85_08595	COG0546	phosphoglycolate phosphatase activity
HYG85_08600	COG0028	Belongs to the TPP enzyme family
HYG85_08615	COG0463	Glycosyl transferase, family 2
HYG85_08615	COG0457	Tetratricopeptide repeat
HYG85_08620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG85_08625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG85_08630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HYG85_08635	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HYG85_08640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG85_08650	COG1256	bacterial-type flagellum assembly
HYG85_08650	COG4786	Flagellar basal body rod
HYG85_08670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYG85_08675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYG85_08680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG85_08685	COG2190	(PTS) system
HYG85_08685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG85_08685	COG1263	PTS System
HYG85_08690	COG2190	(PTS) system
HYG85_08690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG85_08690	COG1263	PTS System
HYG85_08695	COG2190	(PTS) system
HYG85_08695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG85_08695	COG1263	PTS System
HYG85_08700	COG3711	transcriptional antiterminator
HYG85_08705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG85_08710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG85_08715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYG85_08740	COG4786	Flagellar basal body rod
HYG85_08745	COG1077	Cell shape determining protein MreB Mrl
HYG85_08750	COG1609	Transcriptional regulator
HYG85_08765	COG2385	sporulation resulting in formation of a cellular spore
HYG85_08775	COG0058	SHG alpha-glucan phosphorylase activity
HYG85_08780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYG85_08795	COG0733	neurotransmitter:sodium symporter activity
HYG85_08805	COG0251	oxidation-reduction process
HYG85_08815	COG1683	Conserved Protein
HYG85_08820	COG0024	Methionine aminopeptidase
HYG85_08825	COG3620	sequence-specific DNA binding
HYG85_08830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG85_08835	COG1501	Belongs to the glycosyl hydrolase 31 family
HYG85_08840	COG0395	ABC-type sugar transport system, permease component
HYG85_08845	COG4209	transmembrane transport
HYG85_08855	COG2972	Histidine kinase
HYG85_08860	COG4753	response regulator
HYG85_08860	COG2207	Transcriptional regulator
HYG85_08860	COG2207	Transcriptional regulator
HYG85_08860	COG4753	response regulator
HYG85_08865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYG85_08870	COG1640	4-alpha-glucanotransferase
HYG85_08885	COG0504	CTP synthase activity
HYG85_08890	COG0793	Belongs to the peptidase S41A family
HYG85_08925	COG3290	protein histidine kinase activity
HYG85_08930	COG3279	Response regulator of the LytR AlgR family
HYG85_08945	COG3290	protein histidine kinase activity
HYG85_08950	COG3279	Response regulator of the LytR AlgR family
HYG85_08955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYG85_08965	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG85_08985	COG0697	spore germination
HYG85_08995	COG1802	Transcriptional regulator
HYG85_09000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYG85_09010	COG4466	Protein conserved in bacteria
HYG85_09015	COG0681	Belongs to the peptidase S26 family
HYG85_09025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG85_09045	COG2972	Histidine kinase
HYG85_09060	COG3842	ATPase activity
HYG85_09080	COG0697	spore germination
HYG85_09090	COG0617	tRNA 3'-terminal CCA addition
HYG85_09095	COG1482	cell wall glycoprotein biosynthetic process
HYG85_09110	COG1668	transmembrane transport
HYG85_09115	COG4555	ABC transporter
HYG85_09125	COG3681	Belongs to the UPF0597 family
HYG85_09140	COG0463	Glycosyl transferase, family 2
HYG85_09160	COG2246	polysaccharide biosynthetic process
HYG85_09165	COG0463	Glycosyl transferase, family 2
HYG85_09185	COG2207	Transcriptional regulator
HYG85_09200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG85_09275	COG3279	Response regulator of the LytR AlgR family
HYG85_09295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG85_09440	COG0628	permease
HYG85_09445	COG0745	RESPONSE REGULATOR receiver
HYG85_09455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HYG85_09475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYG85_09500	COG5002	protein histidine kinase activity
HYG85_09505	COG0745	RESPONSE REGULATOR receiver
HYG85_09535	COG2373	Large extracellular alpha-helical protein
HYG85_09540	COG1361	Conserved repeat domain
HYG85_09560	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HYG85_09565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG85_09570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYG85_09575	COG1609	Transcriptional regulator
HYG85_09590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG85_09595	COG0537	adenosine 5'-monophosphoramidase activity
HYG85_09600	COG3852	Histidine kinase
HYG85_09625	COG0705	Rhomboid family
HYG85_09625	COG0457	Tetratricopeptide repeat
HYG85_09630	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG85_09635	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG85_09645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG85_09695	COG2815	serine threonine protein kinase
HYG85_09695	COG0515	serine threonine protein kinase
HYG85_09700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYG85_09705	COG2373	Large extracellular alpha-helical protein
HYG85_09715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYG85_09730	COG2188	Transcriptional regulator
HYG85_09740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG85_09745	COG2221	Nitrite and sulphite reductase 4Fe-4S
HYG85_09790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYG85_09795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYG85_09805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYG85_09815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYG85_09820	COG0590	tRNA wobble adenosine to inosine editing
HYG85_09835	COG2207	Transcriptional regulator
HYG85_09835	COG0662	Cupin 2, conserved barrel domain protein
HYG85_09845	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HYG85_09860	COG0737	Belongs to the 5'-nucleotidase family
HYG85_09875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG85_09885	COG1132	(ABC) transporter
HYG85_09890	COG0535	radical SAM domain protein
HYG85_09940	COG3833	ABC-type maltose transport systems, permease component
HYG85_09945	COG1175	transmembrane transport
HYG85_09965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG85_09970	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG85_09995	COG3681	Belongs to the UPF0597 family
HYG85_10000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_10005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_10010	COG1129	ABC transporter
HYG85_10015	COG3547	Transposase (IS116 IS110 IS902 family)
HYG85_10060	COG2508	Transcriptional regulator
HYG85_10065	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG85_10080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYG85_10085	COG0457	Tetratricopeptide repeat
HYG85_10105	COG2188	Transcriptional regulator
HYG85_10110	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG85_10115	COG3845	ABC transporter
HYG85_10120	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG85_10125	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG85_10135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_10145	COG0434	BtpA family
HYG85_10160	COG1573	uracil-dna glycosylase
HYG85_10175	COG2207	Transcriptional regulator
HYG85_10195	COG0395	ABC-type sugar transport system, permease component
HYG85_10200	COG1175	transmembrane transport
HYG85_10205	COG0383	alpha-mannosidase activity
HYG85_10210	COG0406	alpha-ribazole phosphatase activity
HYG85_10220	COG0406	alpha-ribazole phosphatase activity
HYG85_10225	COG0534	Mate efflux family protein
HYG85_10235	COG0371	Dehydrogenase
HYG85_10240	COG0584	glycerophosphoryl diester phosphodiesterase
HYG85_10245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYG85_10250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG85_10265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG85_10275	COG1435	thymidine kinase activity
HYG85_10285	COG1309	transcriptional regulator
HYG85_10290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYG85_10300	COG0628	permease
HYG85_10310	COG3118	belongs to the thioredoxin family
HYG85_10320	COG1595	DNA-templated transcription, initiation
HYG85_10345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYG85_10385	COG0840	transmembrane signaling receptor activity
HYG85_10390	COG2382	esterase
HYG85_10390	COG3507	Belongs to the glycosyl hydrolase 43 family
HYG85_10390	COG3693	PFAM glycoside hydrolase, family 10
HYG85_10395	COG2382	esterase
HYG85_10395	COG3507	Belongs to the glycosyl hydrolase 43 family
HYG85_10395	COG3693	PFAM glycoside hydrolase, family 10
HYG85_10400	COG1653	transport
HYG85_10405	COG1175	transmembrane transport
HYG85_10410	COG0395	ABC-type sugar transport system, permease component
HYG85_10415	COG2207	Transcriptional regulator
HYG85_10415	COG4753	response regulator
HYG85_10420	COG3275	phosphorelay sensor kinase activity
HYG85_10450	COG2188	Transcriptional regulator
HYG85_10455	COG2188	Transcriptional regulator
HYG85_10465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYG85_10475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYG85_10480	COG1533	DNA photolyase activity
HYG85_10500	COG2873	o-acetylhomoserine
HYG85_10510	COG4214	carbohydrate transport
HYG85_10520	COG4213	ABC transporter substrate-binding protein
HYG85_10525	COG4213	ABC transporter substrate-binding protein
HYG85_10530	COG4753	response regulator
HYG85_10530	COG2207	Transcriptional regulator
HYG85_10530	COG2207	Transcriptional regulator
HYG85_10530	COG4753	response regulator
HYG85_10535	COG3275	phosphorelay sensor kinase activity
HYG85_10550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYG85_10560	COG1454	alcohol dehydrogenase
HYG85_10560	COG1012	belongs to the aldehyde dehydrogenase family
HYG85_10580	COG1475	DNA binding
HYG85_10585	COG1192	Involved in chromosome partitioning
HYG85_10590	COG0018	arginyl-trna synthetase
HYG85_10610	COG2153	protein acetylation
HYG85_10620	COG0357	Ribosomal RNA small subunit methyltransferase G
HYG85_10625	COG0445	tRNA wobble uridine modification
HYG85_10630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG85_10635	COG1847	R3H domain protein
HYG85_10640	COG0706	membrane insertase activity
HYG85_10645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYG85_10650	COG0594	ribonuclease P activity
HYG85_10665	COG0592	DNA-directed DNA polymerase activity
HYG85_10670	COG2501	S4 domain
HYG85_10675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYG85_10680	COG0187	DNA topoisomerase II activity
HYG85_10685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG85_10695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HYG85_10710	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG85_10715	COG3845	ABC transporter
HYG85_10720	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG85_10725	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG85_10785	COG1982	Orn Lys Arg decarboxylase major
HYG85_10790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYG85_10795	COG3870	Protein conserved in bacteria
HYG85_10805	COG0470	DNA polymerase III
HYG85_10810	COG1774	PSP1 C-terminal conserved region
HYG85_10815	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYG85_10820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYG85_10825	COG2002	toxin-antitoxin pair type II binding
HYG85_10830	COG1760	l-serine dehydratase
HYG85_10835	COG1760	l-serine dehydratase
HYG85_10850	COG1131	(ABC) transporter
HYG85_10865	COG2715	membrane protein required for spore maturation
HYG85_10875	COG1376	ErfK ybiS ycfS ynhG family protein
HYG85_10890	COG1131	(ABC) transporter
HYG85_10900	COG1595	DNA-templated transcription, initiation
HYG85_10915	COG1217	gtp-binding protein TYPA
HYG85_10920	COG0004	ammonium transporteR
HYG85_10925	COG0347	Belongs to the P(II) protein family
HYG85_10930	COG4753	response regulator
HYG85_10930	COG2207	Transcriptional regulator
HYG85_10935	COG2972	Histidine kinase
HYG85_10945	COG1175	transmembrane transport
HYG85_10960	COG1940	carbohydrate kinase activity
HYG85_10970	COG1609	Transcriptional regulator
HYG85_10975	COG1653	transport
HYG85_10985	COG3833	ABC-type maltose transport systems, permease component
HYG85_11020	COG0149	triose-phosphate isomerase activity
HYG85_11040	COG0166	Belongs to the GPI family
HYG85_11045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG85_11045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG85_11050	COG0084	hydrolase, TatD family'
HYG85_11060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYG85_11070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYG85_11085	COG1695	Transcriptional regulator
HYG85_11090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG85_11095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_11100	COG2070	2-Nitropropane dioxygenase
HYG85_11105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYG85_11115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYG85_11120	COG0511	ligase activity, forming carbon-carbon bonds
HYG85_11125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYG85_11130	COG0439	Biotin carboxylase
HYG85_11135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYG85_11140	COG0825	malonyl-CoA metabolic process
HYG85_11145	COG0726	polysaccharide deacetylase
HYG85_11150	COG1132	(ABC) transporter
HYG85_11155	COG1404	Belongs to the peptidase S8 family
HYG85_11165	COG0641	radical SAM
HYG85_11190	COG1349	DNA-binding transcription factor activity
HYG85_11195	COG0166	Belongs to the GPI family
HYG85_11210	COG3328	transposase activity
HYG85_11220	COG1489	DNA binding
HYG85_11225	COG1827	regulation of RNA biosynthetic process
HYG85_11280	COG3250	beta-galactosidase activity
HYG85_11295	COG1164	Oligoendopeptidase f
HYG85_11300	COG0297	glycogen (starch) synthase activity
HYG85_11305	COG3949	Membrane
HYG85_11405	COG4481	Protein conserved in bacteria
HYG85_11410	COG0360	Binds together with S18 to 16S ribosomal RNA
HYG85_11415	COG0629	single-stranded DNA binding
HYG85_11420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYG85_11435	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HYG85_11440	COG0359	binds to the 23S rRNA
HYG85_11445	COG0305	Participates in initiation and elongation during chromosome replication
HYG85_11450	COG0395	ABC-type sugar transport system, permease component
HYG85_11455	COG1175	transmembrane transport
HYG85_11460	COG1653	transport
HYG85_11465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG85_11465	COG4191	Histidine kinase
HYG85_11470	COG2197	response regulator
HYG85_11520	COG0631	protein serine/threonine phosphatase activity
HYG85_11535	COG2199	diguanylate cyclase activity
HYG85_11535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG85_11545	COG3858	chitin binding
HYG85_11550	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG85_11560	COG0009	L-threonylcarbamoyladenylate synthase
HYG85_11565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYG85_11570	COG0698	ribose 5-phosphate isomerase
HYG85_11580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG85_11590	COG0527	aspartate kinase activity
HYG85_11595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYG85_11630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYG85_11635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYG85_11640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYG85_11645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYG85_11650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYG85_11670	COG1361	Conserved repeat domain
HYG85_11680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG85_11705	COG1132	(ABC) transporter
HYG85_11710	COG1132	(ABC) transporter
HYG85_11730	COG0366	Alpha amylase catalytic
HYG85_11735	COG4990	cell redox homeostasis
HYG85_11740	COG3738	Protein conserved in bacteria
HYG85_11805	COG2309	aminopeptidase activity
HYG85_11810	COG0017	Asparaginyl-tRNA synthetase
HYG85_11825	COG1363	Peptidase, m42
HYG85_11830	COG2188	Transcriptional regulator
HYG85_11840	COG0484	heat shock protein binding
HYG85_11850	COG0205	6-phosphofructokinase activity
HYG85_11870	COG1653	transport
HYG85_11875	COG0395	ABC-type sugar transport system, permease component
HYG85_11880	COG4209	transmembrane transport
HYG85_11885	COG1609	Transcriptional regulator
HYG85_11885	COG2207	Transcriptional regulator
HYG85_11920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYG85_11925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG85_11930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYG85_11935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYG85_11940	COG2088	sporulation resulting in formation of a cellular spore
HYG85_11945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG85_11955	COG0193	aminoacyl-tRNA hydrolase activity
HYG85_11965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYG85_11975	COG2002	toxin-antitoxin pair type II binding
HYG85_11980	COG3956	TIGRFAM MazG family protein
HYG85_11985	COG0776	regulation of translation
HYG85_11990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYG85_12010	COG2208	phosphoserine phosphatase activity
HYG85_12015	COG0037	tRNA processing
HYG85_12020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG85_12030	COG1671	Belongs to the UPF0178 family
HYG85_12055	COG0745	RESPONSE REGULATOR receiver
HYG85_12060	COG5002	protein histidine kinase activity
HYG85_12065	COG1136	(ABC) transporter
HYG85_12160	COG3973	AAA domain
HYG85_12170	COG1191	sigma factor activity
HYG85_12180	COG0383	alpha-mannosidase activity
HYG85_12205	COG1175	transmembrane transport
HYG85_12210	COG3833	ABC-type maltose transport systems, permease component
HYG85_12215	COG3842	ATPase activity
HYG85_12305	COG1652	LysM domain
HYG85_12310	COG4193	domain, Protein
HYG85_12325	COG3299	homolog of phage Mu protein gp47
HYG85_12330	COG3778	Protein conserved in bacteria
HYG85_12400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYG85_12405	COG1376	ErfK ybiS ycfS ynhG family protein
HYG85_12420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYG85_12425	COG0572	uridine kinase
HYG85_12445	COG0077	Prephenate dehydratase
HYG85_12445	COG1605	Chorismate mutase
HYG85_12450	COG2972	Histidine kinase
HYG85_12455	COG2207	Transcriptional regulator
HYG85_12455	COG4753	response regulator
HYG85_12465	COG4209	transmembrane transport
HYG85_12470	COG0395	ABC-type sugar transport system, permease component
HYG85_12480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYG85_12485	COG2373	Large extracellular alpha-helical protein
HYG85_12495	COG2720	vancomycin resistance protein
HYG85_12500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG85_12505	COG1522	sequence-specific DNA binding
HYG85_12510	COG0436	Aminotransferase
HYG85_12520	COG0735	belongs to the Fur family
HYG85_12550	COG1070	Carbohydrate kinase
HYG85_12555	COG0235	Class ii aldolase
HYG85_12565	COG4209	transmembrane transport
HYG85_12570	COG0395	ABC-type sugar transport system, permease component
HYG85_12575	COG1070	Carbohydrate kinase
HYG85_12585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYG85_12605	COG0673	inositol 2-dehydrogenase activity
HYG85_12615	COG0383	alpha-mannosidase activity
HYG85_12625	COG4977	sequence-specific DNA binding
HYG85_12625	COG1917	Cupin 2, conserved barrel domain protein
HYG85_12630	COG4209	transmembrane transport
HYG85_12635	COG0395	ABC-type sugar transport system, permease component
HYG85_12640	COG1653	transport
HYG85_12645	COG0673	inositol 2-dehydrogenase activity
HYG85_12660	COG3250	beta-galactosidase activity
HYG85_12670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYG85_12675	COG0673	inositol 2-dehydrogenase activity
HYG85_12680	COG2207	Transcriptional regulator
HYG85_12680	COG4753	response regulator
HYG85_12690	COG3773	Cell wall hydrolase
HYG85_12695	COG4209	transmembrane transport
HYG85_12700	COG0395	ABC-type sugar transport system, permease component
HYG85_12705	COG1653	transport
HYG85_12730	COG2205	protein histidine kinase activity
HYG85_12735	COG0745	RESPONSE REGULATOR receiver
HYG85_12740	COG1193	negative regulation of DNA recombination
HYG85_12745	COG2207	Transcriptional regulator
HYG85_12750	COG3534	alpha-L-arabinofuranosidase
HYG85_12755	COG0739	heme binding
HYG85_12765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYG85_12770	COG3481	metal-dependent phosphohydrolase, HD sub domain
HYG85_12820	COG0733	neurotransmitter:sodium symporter activity
HYG85_12885	COG0275	rRNA processing
HYG85_12895	COG3848	Pyruvate phosphate dikinase
HYG85_12895	COG0574	Belongs to the PEP-utilizing enzyme family
HYG85_12910	COG2207	Transcriptional regulator
HYG85_12915	COG1846	Transcriptional regulator
HYG85_12920	COG0735	belongs to the Fur family
HYG85_12945	COG4209	transmembrane transport
HYG85_12950	COG0395	ABC-type sugar transport system, permease component
HYG85_12980	COG1609	Transcriptional regulator
HYG85_12985	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYG85_13045	COG3209	COG3209 Rhs family protein
HYG85_13070	COG4209	transmembrane transport
HYG85_13075	COG0395	ABC-type sugar transport system, permease component
HYG85_13085	COG4753	response regulator
HYG85_13085	COG2207	Transcriptional regulator
HYG85_13090	COG3275	phosphorelay sensor kinase activity
HYG85_13115	COG0375	protein maturation
HYG85_13120	COG2226	methyltransferase
HYG85_13125	COG3119	arylsulfatase activity
HYG85_13130	COG4978	Transcriptional regulator
HYG85_13130	COG0789	Transcriptional regulator
HYG85_13135	COG0840	transmembrane signaling receptor activity
HYG85_13140	COG1811	Na channel or pump
HYG85_13165	COG2375	cellular response to nickel ion
HYG85_13165	COG1132	(ABC) transporter
HYG85_13170	COG1132	(ABC) transporter
HYG85_13180	COG4171	peptide transport system, permease
HYG85_13185	COG0444	Belongs to the ABC transporter superfamily
HYG85_13195	COG0747	negative chemotaxis
HYG85_13200	COG0456	acetyltransferase
HYG85_13205	COG3706	GGDEF domain
HYG85_13225	COG0641	radical SAM
HYG85_13230	COG1233	COG1233 Phytoene dehydrogenase and related
HYG85_13235	COG2207	Transcriptional regulator
HYG85_13235	COG3708	Transcriptional regulator
HYG85_13295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG85_13300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG85_13315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYG85_13335	COG3321	synthase
HYG85_13335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYG85_13335	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_13335	COG0300	oxidoreductase activity
HYG85_13335	COG0318	PFAM AMP-dependent synthetase and ligase
HYG85_13340	COG0367	asparagine synthase
HYG85_13375	COG1022	Amp-dependent synthetase and ligase
HYG85_13380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_13385	COG1794	racemase activity, acting on amino acids and derivatives
HYG85_13400	COG1979	alcohol dehydrogenase
HYG85_13430	COG0463	Glycosyl transferase, family 2
HYG85_13430	COG0457	Tetratricopeptide repeat
HYG85_13455	COG0564	pseudouridine synthase activity
HYG85_13460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYG85_13470	COG2972	Histidine kinase
HYG85_13475	COG2207	Transcriptional regulator
HYG85_13485	COG1175	transmembrane transport
HYG85_13490	COG0395	ABC-type sugar transport system, permease component
HYG85_13495	COG0840	transmembrane signaling receptor activity
HYG85_13515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG85_13520	COG1120	ATPase activity
HYG85_13530	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HYG85_13535	COG1606	tRNA processing
HYG85_13540	COG1691	(AIR) carboxylase
HYG85_13555	COG2160	L-arabinose isomerase activity
HYG85_13560	COG1069	ribulokinase activity
HYG85_13570	COG4115	mRNA cleavage
HYG85_13585	COG0673	inositol 2-dehydrogenase activity
HYG85_13595	COG1737	Transcriptional regulator
HYG85_13600	COG2971	BadF BadG BcrA BcrD
HYG85_13605	COG3876	Protein conserved in bacteria
HYG85_13620	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYG85_13630	COG0395	ABC-type sugar transport system, permease component
HYG85_13635	COG4209	transmembrane transport
HYG85_13640	COG1609	Transcriptional regulator
HYG85_13650	COG3119	arylsulfatase activity
HYG85_13685	COG4209	transmembrane transport
HYG85_13690	COG0395	ABC-type sugar transport system, permease component
HYG85_13705	COG3119	arylsulfatase activity
HYG85_13710	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYG85_13720	COG0534	Mate efflux family protein
HYG85_13730	COG5634	Uncharacterized conserved protein (DUF2278)
HYG85_13735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYG85_13755	COG0475	glutathione-regulated potassium exporter activity
HYG85_13765	COG0038	chloride channel
HYG85_13780	COG2223	nitrite transmembrane transporter activity
HYG85_13785	COG0789	Transcriptional regulator
HYG85_13795	COG1307	EDD domain protein, DegV family
HYG85_13800	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYG85_13815	COG1404	Belongs to the peptidase S8 family
HYG85_13825	COG4585	Histidine kinase
HYG85_13830	COG2197	response regulator
HYG85_13840	COG1131	(ABC) transporter
HYG85_13860	COG0673	inositol 2-dehydrogenase activity
HYG85_13870	COG0673	inositol 2-dehydrogenase activity
HYG85_13880	COG0708	Exodeoxyribonuclease III
HYG85_13890	COG3706	GGDEF domain
HYG85_13895	COG0840	transmembrane signaling receptor activity
HYG85_13900	COG1609	Transcriptional regulator
HYG85_13965	COG0745	RESPONSE REGULATOR receiver
HYG85_13970	COG5002	protein histidine kinase activity
HYG85_13975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYG85_13980	COG0640	Transcriptional regulator
HYG85_13985	COG2217	Heavy metal translocating P-type atpase
HYG85_13995	COG1917	Cupin 2, conserved barrel domain protein
HYG85_13995	COG4977	sequence-specific DNA binding
HYG85_14000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYG85_14005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG85_14010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG85_14015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG85_14020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG85_14035	COG0745	RESPONSE REGULATOR receiver
HYG85_14040	COG4932	domain protein
HYG85_14040	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HYG85_14040	COG3266	domain, Protein
HYG85_14080	COG4978	Transcriptional regulator
HYG85_14080	COG0789	Transcriptional regulator
HYG85_14095	COG0395	ABC-type sugar transport system, permease component
HYG85_14100	COG2972	Histidine kinase
HYG85_14105	COG2207	Transcriptional regulator
HYG85_14105	COG4753	response regulator
HYG85_14115	COG5426	von Willebrand factor, type A
HYG85_14120	COG0366	Alpha amylase catalytic
HYG85_14125	COG1595	DNA-templated transcription, initiation
HYG85_14140	COG1312	Catalyzes the dehydration of D-mannonate
HYG85_14145	COG0246	Mannitol dehydrogenase
HYG85_14160	COG1704	LemA family
HYG85_14230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYG85_14230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYG85_14235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYG85_14240	COG1522	sequence-specific DNA binding
HYG85_14255	COG2391	methyltransferase activity
HYG85_14265	COG2391	methyltransferase activity
HYG85_14270	COG0583	DNA-binding transcription factor activity
HYG85_14280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYG85_14285	COG0463	Glycosyl transferase, family 2
HYG85_14300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG85_14310	COG2897	thiosulfate sulfurtransferase activity
HYG85_14325	COG1846	Transcriptional regulator
HYG85_14330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG85_14335	COG0765	amino acid transport
HYG85_14350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG85_14360	COG1429	ligase activity, forming nitrogen-metal bonds
HYG85_14370	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HYG85_14370	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HYG85_14375	COG1175	transmembrane transport
HYG85_14380	COG0395	ABC-type sugar transport system, permease component
HYG85_14385	COG1653	transport
HYG85_14400	COG1073	alpha beta
HYG85_14405	COG1492	cobalamin metabolic process
HYG85_14415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG85_14420	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HYG85_14425	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYG85_14440	COG4753	response regulator
HYG85_14440	COG2207	Transcriptional regulator
HYG85_14445	COG3275	phosphorelay sensor kinase activity
HYG85_14450	COG1653	transport
HYG85_14455	COG1175	transmembrane transport
HYG85_14460	COG0395	ABC-type sugar transport system, permease component
HYG85_14490	COG0488	(ABC) transporter
HYG85_14525	COG3853	Toxic anion resistance protein (TelA)
HYG85_14530	COG1725	Transcriptional regulator
HYG85_14535	COG1131	(ABC) transporter
HYG85_14550	COG3119	arylsulfatase activity
HYG85_14555	COG2207	Transcriptional regulator
HYG85_14560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG85_14560	COG2199	diguanylate cyclase activity
HYG85_14570	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG85_14580	COG0210	DNA helicase
HYG85_14595	COG1486	melibiose metabolic process
HYG85_14600	COG2207	Transcriptional regulator
HYG85_14620	COG0492	ferredoxin-NADP+ reductase activity
HYG85_14625	COG0791	NLP P60 protein
HYG85_14625	COG1388	LysM domain
HYG85_14625	COG3103	Sh3 type 3 domain protein
HYG85_14630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYG85_14645	COG1132	(ABC) transporter
HYG85_14650	COG1132	(ABC) transporter
HYG85_14655	COG0322	excinuclease ABC activity
HYG85_14660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HYG85_14695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HYG85_14700	COG0156	8-amino-7-oxononanoate synthase activity
HYG85_14710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYG85_14715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYG85_14735	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HYG85_14760	COG3845	ABC transporter
HYG85_14765	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG85_14770	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG85_14775	COG1957	nucleoside hydrolase
HYG85_14785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_14800	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HYG85_14810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_14830	COG1309	transcriptional regulator
HYG85_14855	COG2211	Major facilitator Superfamily
HYG85_14855	COG2190	(PTS) system
HYG85_14860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYG85_14865	COG1660	Displays ATPase and GTPase activities
HYG85_14875	COG1481	regulation of sporulation
HYG85_14880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG85_14890	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_14895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HYG85_14900	COG1316	TRANSCRIPTIONal
HYG85_14905	COG1316	TRANSCRIPTIONal
HYG85_14920	COG0728	peptidoglycan biosynthetic process
HYG85_14980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG85_14985	COG3842	ATPase activity
HYG85_14990	COG3835	regulator
HYG85_14995	COG2884	Cell division ATP-binding protein ftsE
HYG85_15000	COG2177	Part of the ABC transporter FtsEX involved in
HYG85_15005	COG0739	heme binding
HYG85_15010	COG3409	Peptidoglycan-binding domain 1 protein
HYG85_15010	COG0793	Belongs to the peptidase S41A family
HYG85_15015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYG85_15040	COG1131	(ABC) transporter
HYG85_15060	COG0556	nucleotide-excision repair
HYG85_15115	COG4209	transmembrane transport
HYG85_15120	COG0395	ABC-type sugar transport system, permease component
HYG85_15125	COG1653	transport
HYG85_15130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYG85_15145	COG0653	protein targeting
HYG85_15155	COG0835	chemotaxis
HYG85_15160	COG4492	Belongs to the UPF0735 family
HYG85_15165	COG0460	homoserine dehydrogenase
HYG85_15170	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HYG85_15180	COG2183	response to ionizing radiation
HYG85_15195	COG2199	diguanylate cyclase activity
HYG85_15220	COG1950	PFAM Membrane protein of
HYG85_15225	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HYG85_15235	COG0802	atpase or kinase
HYG85_15240	COG1214	PFAM Peptidase M22, glycoprotease
HYG85_15245	COG0456	acetyltransferase
HYG85_15255	COG1067	ATP-dependent peptidase activity
HYG85_15260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYG85_15270	COG1234	tRNA 3'-trailer cleavage
HYG85_15285	COG1528	Iron-storage protein
HYG85_15290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYG85_15400	COG0463	Glycosyl transferase, family 2
HYG85_15435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HYG85_15470	COG1091	dTDP-4-dehydrorhamnose reductase activity
HYG85_15505	COG1216	Glycosyl transferase, family 2
HYG85_15505	COG0438	transferase activity, transferring glycosyl groups
HYG85_15520	COG0463	Glycosyl transferase, family 2
HYG85_15520	COG0457	Tetratricopeptide repeat
HYG85_15535	COG1388	LysM domain
HYG85_15535	COG4641	Protein conserved in bacteria
HYG85_15560	COG1597	lipid kinase activity
HYG85_15580	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HYG85_15595	COG1269	ATP hydrolysis coupled proton transport
HYG85_15625	COG1394	ATPase activity, coupled to movement of substances
HYG85_15630	COG1074	ATP-dependent DNA helicase activity
HYG85_15645	COG0673	inositol 2-dehydrogenase activity
HYG85_15660	COG2226	methyltransferase
HYG85_15665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYG85_15680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG85_15685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG85_15690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HYG85_15700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYG85_15705	COG1876	peptidase activity
HYG85_15725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYG85_15785	COG2207	Transcriptional regulator
HYG85_15785	COG3708	Transcriptional regulator
HYG85_15815	COG1070	Carbohydrate kinase
HYG85_15820	COG0277	FAD linked oxidase domain protein
HYG85_15825	COG1971	Probably functions as a manganese efflux pump
HYG85_15830	COG1132	(ABC) transporter
HYG85_15850	COG0673	inositol 2-dehydrogenase activity
HYG85_15860	COG1653	transport
HYG85_15880	COG1609	Transcriptional regulator
HYG85_15885	COG0019	diaminopimelate decarboxylase activity
HYG85_15920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYG85_15925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG85_15930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG85_15935	COG1120	ATPase activity
HYG85_15955	COG2197	response regulator
HYG85_15965	COG1361	Conserved repeat domain
HYG85_15965	COG2911	Protein conserved in bacteria
HYG85_15965	COG3266	domain, Protein
HYG85_16000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYG85_16005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG85_16005	COG1328	CTP reductase activity
HYG85_16015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYG85_16065	COG0514	ATP-dependent DNA helicase (RecQ)
HYG85_16070	COG1695	Transcriptional regulator
HYG85_16140	COG0191	fructose-bisphosphate aldolase activity
HYG85_16150	COG0745	RESPONSE REGULATOR receiver
HYG85_16155	COG2770	Histidine kinase
HYG85_16155	COG2205	protein histidine kinase activity
HYG85_16160	COG1285	pathogenesis
HYG85_16165	COG1653	transport
HYG85_16170	COG4209	transmembrane transport
HYG85_16175	COG0395	ABC-type sugar transport system, permease component
HYG85_16185	COG3119	arylsulfatase activity
HYG85_16190	COG3119	arylsulfatase activity
HYG85_16195	COG2207	Transcriptional regulator
HYG85_16240	COG1129	ABC transporter
HYG85_16245	COG1132	(ABC) transporter
HYG85_16245	COG2375	cellular response to nickel ion
HYG85_16250	COG1132	(ABC) transporter
HYG85_16255	COG1376	ErfK ybiS ycfS ynhG family protein
HYG85_16265	COG4989	oxidoreductase activity
HYG85_16280	COG1609	Transcriptional regulator
HYG85_16285	COG0840	transmembrane signaling receptor activity
HYG85_16285	COG5278	phosphoserine phosphatase activity
HYG85_16295	COG0765	amino acid transport
HYG85_16300	COG1126	abc transporter atp-binding protein
HYG85_16305	COG1309	transcriptional regulator
HYG85_16320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG85_16335	COG1070	Carbohydrate kinase
HYG85_16340	COG1609	Transcriptional regulator
HYG85_16365	COG0697	spore germination
HYG85_16370	COG1653	transport
HYG85_16375	COG4209	transmembrane transport
HYG85_16380	COG0395	ABC-type sugar transport system, permease component
HYG85_16395	COG2207	Transcriptional regulator
HYG85_16400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYG85_16405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG85_16415	COG2119	membrane
HYG85_16435	COG2207	Transcriptional regulator
HYG85_16435	COG1917	Cupin 2, conserved barrel domain protein
HYG85_16445	COG1175	transmembrane transport
HYG85_16450	COG0395	ABC-type sugar transport system, permease component
HYG85_16515	COG0789	Transcriptional regulator
HYG85_16515	COG4978	Transcriptional regulator
HYG85_16530	COG0745	RESPONSE REGULATOR receiver
HYG85_16535	COG5002	protein histidine kinase activity
HYG85_16550	COG3119	arylsulfatase activity
HYG85_16565	COG1129	ABC transporter
HYG85_16570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_16590	COG2972	Histidine kinase
HYG85_16600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG85_16605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYG85_16640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG85_16660	COG1132	(ABC) transporter
HYG85_16660	COG2375	cellular response to nickel ion
HYG85_16665	COG1132	(ABC) transporter
HYG85_16675	COG1129	ABC transporter
HYG85_16705	COG1021	2,3-dihydroxybenzoate-AMP ligase
HYG85_16720	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYG85_16725	COG1169	isochorismate synthase
HYG85_16735	COG2267	carboxylic ester hydrolase activity
HYG85_16740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HYG85_16745	COG0318	PFAM AMP-dependent synthetase and ligase
HYG85_16750	COG4948	Mandelate Racemase Muconate Lactonizing
HYG85_16775	COG1940	carbohydrate kinase activity
HYG85_16780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYG85_16805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG85_16810	COG0793	Belongs to the peptidase S41A family
HYG85_16820	COG0577	efflux transmembrane transporter activity
HYG85_16830	COG1136	(ABC) transporter
HYG85_16840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYG85_16845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYG85_16850	COG1388	LysM domain
HYG85_16850	COG3858	chitin binding
HYG85_16885	COG0697	spore germination
HYG85_16895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG85_16920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG85_16940	COG0840	transmembrane signaling receptor activity
HYG85_16945	COG0133	tryptophan synthase activity
HYG85_16955	COG2207	Transcriptional regulator
HYG85_16955	COG4753	response regulator
HYG85_16960	COG2972	Histidine kinase
HYG85_16970	COG1129	ABC transporter
HYG85_16975	COG4211	Belongs to the binding-protein-dependent transport system permease family
HYG85_16985	COG0671	phosphoesterase, PA-phosphatase related
HYG85_17000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYG85_17005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYG85_17010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYG85_17015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYG85_17020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYG85_17025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYG85_17030	COG0151	Belongs to the GarS family
HYG85_17060	COG1609	Transcriptional regulator
HYG85_17065	COG1869	D-ribose catabolic process
HYG85_17070	COG0434	BtpA family
HYG85_17075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_17080	COG1129	ABC transporter
HYG85_17085	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_17090	COG1879	ABC-type sugar transport system periplasmic component
HYG85_17095	COG3859	Proton-coupled thiamine transporter YuaJ
HYG85_17105	COG0785	Cytochrome C biogenesis protein
HYG85_17110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYG85_17115	COG3880	PFAM UvrB UvrC protein
HYG85_17120	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYG85_17125	COG0542	response to heat
HYG85_17135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG85_17140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYG85_17160	COG1473	amidohydrolase
HYG85_17165	COG0583	DNA-binding transcription factor activity
HYG85_17170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG85_17180	COG0110	maltose O-acetyltransferase activity
HYG85_17185	COG0347	Belongs to the P(II) protein family
HYG85_17190	COG0004	ammonium transporteR
HYG85_17205	COG1120	ATPase activity
HYG85_17215	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HYG85_17225	COG1797	cobyrinic acid a,c-diamide synthase activity
HYG85_17235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HYG85_17260	COG2099	Precorrin-6x reductase
HYG85_17270	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HYG85_17335	COG0535	radical SAM domain protein
HYG85_17355	COG1840	ABC-type Fe3 transport system, periplasmic component
HYG85_17360	COG1178	ABC-type Fe3 transport system permease component
HYG85_17460	COG4209	transmembrane transport
HYG85_17465	COG0395	ABC-type sugar transport system, permease component
HYG85_17470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYG85_17475	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG85_17485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYG85_17490	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG85_17520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HYG85_17530	COG0602	queuosine metabolic process
HYG85_17535	COG0720	synthase
HYG85_17540	COG1924	4 iron, 4 sulfur cluster binding
HYG85_17575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYG85_17580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYG85_17585	COG0438	transferase activity, transferring glycosyl groups
HYG85_17590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYG85_17600	COG0628	permease
HYG85_17605	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG85_17610	COG2226	methyltransferase
HYG85_17620	COG0789	Transcriptional regulator
HYG85_17620	COG4978	Transcriptional regulator
HYG85_17640	COG1921	L-seryl-tRNASec selenium transferase activity
HYG85_17655	COG2030	dehydratase
HYG85_17660	COG1960	acyl-CoA dehydrogenase activity
HYG85_17665	COG2086	electron transfer activity
HYG85_17670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG85_17675	COG2972	Histidine kinase
HYG85_17680	COG4753	response regulator
HYG85_17680	COG2207	Transcriptional regulator
HYG85_17685	COG1653	transport
HYG85_17700	COG3842	ATPase activity
HYG85_17705	COG3842	ATPase activity
HYG85_17710	COG1063	alcohol dehydrogenase
HYG85_17715	COG0698	ribose 5-phosphate isomerase
HYG85_17720	COG2376	Dihydroxyacetone kinase
HYG85_17730	COG0205	6-phosphofructokinase activity
HYG85_17740	COG0549	Belongs to the carbamate kinase family
HYG85_17745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYG85_17750	COG4636	protein conserved in cyanobacteria
HYG85_17775	COG1653	transport
HYG85_17785	COG2211	Major facilitator Superfamily
HYG85_17790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYG85_17795	COG0714	Associated with various cellular activities
HYG85_17805	COG1305	Transglutaminase-like
HYG85_17810	COG1595	DNA-templated transcription, initiation
HYG85_17835	COG1191	sigma factor activity
HYG85_17850	COG1131	(ABC) transporter
HYG85_17865	COG1832	CoA-binding protein
HYG85_17890	COG1309	transcriptional regulator
HYG85_17925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYG85_17930	COG3842	ATPase activity
HYG85_17975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYG85_17980	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG85_17995	COG1278	Cold shock
HYG85_18005	COG0067	glutamate synthase
HYG85_18005	COG0069	glutamate synthase activity
HYG85_18005	COG0070	glutamate synthase
HYG85_18020	COG2972	Histidine kinase
HYG85_18025	COG4753	response regulator
HYG85_18025	COG2207	Transcriptional regulator
HYG85_18030	COG1129	ABC transporter
HYG85_18035	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_18045	COG1063	alcohol dehydrogenase
HYG85_18050	COG1070	Carbohydrate kinase
HYG85_18060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG85_18065	COG1295	ribonuclease BN
HYG85_18075	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYG85_18080	COG2207	Transcriptional regulator
HYG85_18080	COG4753	response regulator
HYG85_18085	COG2972	Histidine kinase
HYG85_18095	COG4209	transmembrane transport
HYG85_18100	COG0395	ABC-type sugar transport system, permease component
HYG85_18105	COG1653	transport
HYG85_18110	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG85_18115	COG5520	Belongs to the glycosyl hydrolase 30 family
HYG85_18120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYG85_18125	COG1959	2 iron, 2 sulfur cluster binding
HYG85_18130	COG1051	belongs to the nudix hydrolase family
HYG85_18140	COG0028	Belongs to the TPP enzyme family
HYG85_18155	COG1131	(ABC) transporter
HYG85_18160	COG1725	Transcriptional regulator
HYG85_18165	COG1136	(ABC) transporter
HYG85_18170	COG0577	efflux transmembrane transporter activity
HYG85_18175	COG0488	(ABC) transporter
HYG85_18190	COG1509	lysine 2,3-aminomutase activity
HYG85_18195	COG0745	RESPONSE REGULATOR receiver
HYG85_18200	COG2205	protein histidine kinase activity
HYG85_18205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYG85_18215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG85_18220	COG0765	amino acid transport
HYG85_18230	COG2385	sporulation resulting in formation of a cellular spore
HYG85_18235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYG85_18240	COG0542	response to heat
HYG85_18245	COG1959	2 iron, 2 sulfur cluster binding
HYG85_18255	COG0822	iron-sulfur transferase activity
HYG85_18260	COG0482	sulfurtransferase activity
HYG85_18265	COG3621	Patatin-like phospholipase
HYG85_18270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG85_18275	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG85_18280	COG2390	Transcriptional regulator
HYG85_18295	COG0149	triose-phosphate isomerase activity
HYG85_18300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYG85_18305	COG0148	phosphopyruvate hydratase activity
HYG85_18320	COG0557	exoribonuclease II activity
HYG85_18325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYG85_18335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYG85_18355	COG2076	Multidrug Resistance protein
HYG85_18365	COG2267	carboxylic ester hydrolase activity
HYG85_18435	COG1175	transmembrane transport
HYG85_18440	COG0395	ABC-type sugar transport system, permease component
HYG85_18445	COG3459	Glycosyltransferase 36 associated
HYG85_18460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYG85_18490	COG2814	Major facilitator Superfamily
HYG85_18495	COG0316	Belongs to the HesB IscA family
HYG85_18495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HYG85_18500	COG2188	Transcriptional regulator
HYG85_18510	COG1607	acyl-coa hydrolase
HYG85_18515	COG3246	L-lysine catabolic process to acetate
HYG85_18530	COG0604	alcohol dehydrogenase
HYG85_18535	COG1509	lysine 2,3-aminomutase activity
HYG85_18545	COG1193	negative regulation of DNA recombination
HYG85_18550	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG85_18555	COG5012	cobalamin binding
HYG85_18575	COG2972	Histidine kinase
HYG85_18580	COG4753	response regulator
HYG85_18580	COG2207	Transcriptional regulator
HYG85_18590	COG4209	transmembrane transport
HYG85_18595	COG0395	ABC-type sugar transport system, permease component
HYG85_18610	COG2986	histidine ammonia-lyase
HYG85_18615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYG85_18630	COG3404	Formiminotransferase-cyclodeaminase
HYG85_18645	COG1609	Transcriptional regulator
HYG85_18650	COG2197	response regulator
HYG85_18655	COG2972	Histidine kinase
HYG85_18665	COG1129	ABC transporter
HYG85_18670	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_18690	COG4753	response regulator
HYG85_18690	COG2207	Transcriptional regulator
HYG85_18695	COG2972	Histidine kinase
HYG85_18700	COG1129	ABC transporter
HYG85_18705	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_18725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG85_18730	COG1012	belongs to the aldehyde dehydrogenase family
HYG85_18745	COG3962	Belongs to the TPP enzyme family
HYG85_18755	COG0673	inositol 2-dehydrogenase activity
HYG85_18760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYG85_18765	COG1131	(ABC) transporter
HYG85_18775	COG4166	transmembrane transport
HYG85_18780	COG0601	transmembrane transport
HYG85_18785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG85_18790	COG0444	Belongs to the ABC transporter superfamily
HYG85_18795	COG4608	Belongs to the ABC transporter superfamily
HYG85_18805	COG1132	(ABC) transporter
HYG85_18845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYG85_18875	COG1609	Transcriptional regulator
HYG85_18895	COG3030	protein affecting phage T7 exclusion by the F plasmid
HYG85_18900	COG2207	Transcriptional regulator
HYG85_18910	COG2972	Histidine kinase
HYG85_18915	COG2207	Transcriptional regulator
HYG85_18915	COG4753	response regulator
HYG85_18930	COG1129	ABC transporter
HYG85_18935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_18940	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_18960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYG85_18965	COG3275	phosphorelay sensor kinase activity
HYG85_18970	COG1879	ABC-type sugar transport system periplasmic component
HYG85_18975	COG2207	Transcriptional regulator
HYG85_18975	COG4753	response regulator
HYG85_18990	COG4211	Belongs to the binding-protein-dependent transport system permease family
HYG85_18995	COG1082	Xylose isomerase domain protein TIM barrel
HYG85_19000	COG0673	inositol 2-dehydrogenase activity
HYG85_19025	COG2153	protein acetylation
HYG85_19040	COG2235	arginine
HYG85_19045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYG85_19050	COG3804	dihydrodipicolinate reductase
HYG85_19060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYG85_19070	COG5012	cobalamin binding
HYG85_19080	COG3457	Alanine racemase
HYG85_19105	COG3958	Transketolase
HYG85_19110	COG3959	Transketolase, thiamine diphosphate binding domain
HYG85_19145	COG0530	calcium, potassium:sodium antiporter activity
HYG85_19150	COG1307	EDD domain protein, DegV family
HYG85_19185	COG3386	PFAM SMP-30 Gluconolaconase
HYG85_19195	COG0129	dihydroxy-acid dehydratase activity
HYG85_19200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYG85_19205	COG2207	Transcriptional regulator
HYG85_19210	COG3250	beta-galactosidase activity
HYG85_19225	COG0659	secondary active sulfate transmembrane transporter activity
HYG85_19245	COG0646	methionine synthase
HYG85_19245	COG1410	methionine synthase
HYG85_19250	COG0646	methionine synthase
HYG85_19250	COG1410	methionine synthase
HYG85_19255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG85_19260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYG85_19265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYG85_19275	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_19315	COG0577	efflux transmembrane transporter activity
HYG85_19315	COG1136	(ABC) transporter
HYG85_19325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYG85_19330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYG85_19335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYG85_19340	COG0066	3-isopropylmalate dehydratase activity
HYG85_19345	COG0473	3-isopropylmalate dehydrogenase activity
HYG85_19350	COG0129	dihydroxy-acid dehydratase activity
HYG85_19355	COG0028	Belongs to the TPP enzyme family
HYG85_19360	COG0456	acetyltransferase
HYG85_19360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HYG85_19370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYG85_19380	COG0330	HflC and HflK could
HYG85_19385	COG0330	HflC and HflK could
HYG85_19390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYG85_19430	COG0165	Argininosuccinate lyase
HYG85_19435	COG0137	argininosuccinate synthase activity
HYG85_19440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG85_19445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYG85_19450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYG85_19460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG85_19465	COG0505	Belongs to the CarA family
HYG85_19470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYG85_19475	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG85_19485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG85_19485	COG0493	'glutamate synthase
HYG85_19505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYG85_19505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYG85_19515	COG1555	photosystem II stabilization
HYG85_19515	COG1596	polysaccharide export
HYG85_19520	COG0745	RESPONSE REGULATOR receiver
HYG85_19525	COG5002	protein histidine kinase activity
HYG85_19535	COG0658	competence protein
HYG85_19535	COG2333	competence protein COMEC
HYG85_19545	COG0268	Binds directly to 16S ribosomal RNA
HYG85_19550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HYG85_19560	COG0481	GTPase activity
HYG85_19565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG85_19570	COG1420	regulation of RNA biosynthetic process
HYG85_19575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYG85_19580	COG0443	Heat shock 70 kDa protein
HYG85_19585	COG0484	heat shock protein binding
HYG85_19590	COG2264	protein methyltransferase activity
HYG85_19595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYG85_19600	COG2201	protein-glutamate methylesterase activity
HYG85_19610	COG0301	tRNA thio-modification
HYG85_19620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG85_19625	COG4472	Bacterial protein of unknown function (DUF965)
HYG85_19630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYG85_19640	COG0735	belongs to the Fur family
HYG85_19645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYG85_19655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYG85_19660	COG4122	O-methyltransferase activity
HYG85_19665	COG0826	peptidase U32
HYG85_19700	COG2226	methyltransferase
HYG85_19745	COG2255	four-way junction helicase activity
HYG85_19760	COG1335	isochorismatase
HYG85_19770	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HYG85_19775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYG85_19780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG85_19785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYG85_19790	COG0006	proline dipeptidase activity
HYG85_19795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYG85_19800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG85_19800	COG2199	diguanylate cyclase activity
HYG85_19810	COG3854	ATPases associated with a variety of cellular activities
HYG85_19850	COG1302	Protein conserved in bacteria
HYG85_19855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG85_19860	COG1570	exodeoxyribonuclease VII activity
HYG85_19865	COG1722	exodeoxyribonuclease VII activity
HYG85_19890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HYG85_19900	COG1438	arginine binding
HYG85_19905	COG0497	DNA recombination
HYG85_19910	COG0750	zinc metalloprotease
HYG85_19915	COG0745	RESPONSE REGULATOR receiver
HYG85_19925	COG1309	transcriptional regulator
HYG85_19940	COG3706	GGDEF domain
HYG85_19960	COG0154	amidase activity
HYG85_19975	COG0494	nUDIX hydrolase
HYG85_19990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYG85_20015	COG0366	Alpha amylase catalytic
HYG85_20025	COG1175	transmembrane transport
HYG85_20030	COG3833	ABC-type maltose transport systems, permease component
HYG85_20035	COG0366	Alpha amylase catalytic
HYG85_20040	COG1609	Transcriptional regulator
HYG85_20050	COG1454	alcohol dehydrogenase
HYG85_20055	COG5492	domain, Protein
HYG85_20060	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HYG85_20070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG85_20085	COG1192	Involved in chromosome partitioning
HYG85_20090	COG1475	DNA binding
HYG85_20105	COG2003	Belongs to the UPF0758 family
HYG85_20390	COG3620	sequence-specific DNA binding
HYG85_20405	COG1199	ATP-dependent helicase activity
HYG85_20445	COG0582	viral genome integration into host DNA
HYG85_20450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG85_20465	COG2207	Transcriptional regulator
HYG85_20480	COG2244	polysaccharide biosynthetic process
HYG85_20505	COG3655	Transcriptional regulator
HYG85_20545	COG1725	Transcriptional regulator
HYG85_20550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYG85_20555	COG1121	(ABC) transporter
HYG85_20560	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYG85_20565	COG0735	belongs to the Fur family
HYG85_20575	COG3300	MHYT domain
HYG85_20575	COG5001	Diguanylate cyclase
HYG85_20580	COG0343	queuine tRNA-ribosyltransferase activity
HYG85_20585	COG1862	Preprotein translocase
HYG85_20605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG85_20610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG85_20610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG85_20615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYG85_20615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYG85_20625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG85_20630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYG85_20635	COG1490	D-aminoacyl-tRNA deacylase activity
HYG85_20640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG85_20645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG85_20660	COG0512	Glutamine amidotransferase of anthranilate synthase
HYG85_20660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYG85_20665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYG85_20670	COG0134	indole-3-glycerol-phosphate synthase activity
HYG85_20675	COG0135	phosphoribosylanthranilate isomerase activity
HYG85_20685	COG0159	tryptophan synthase activity
HYG85_20690	COG0124	histidyl-tRNA synthetase
HYG85_20695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYG85_20710	COG3086	response to oxidative stress
HYG85_20715	COG4977	sequence-specific DNA binding
HYG85_20715	COG1917	Cupin 2, conserved barrel domain protein
HYG85_20720	COG0679	Auxin Efflux Carrier
HYG85_20735	COG2207	Transcriptional regulator
HYG85_20735	COG4753	response regulator
HYG85_20740	COG2972	Histidine kinase
HYG85_20745	COG4209	transmembrane transport
HYG85_20750	COG0395	ABC-type sugar transport system, permease component
HYG85_20755	COG1653	transport
HYG85_20760	COG5578	integral membrane protein
HYG85_20765	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYG85_20790	COG1609	Transcriptional regulator
HYG85_20790	COG2207	Transcriptional regulator
HYG85_20820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYG85_20825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG85_20835	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_20840	COG0183	Belongs to the thiolase family
HYG85_20860	COG1454	alcohol dehydrogenase
HYG85_20875	COG0706	membrane insertase activity
HYG85_20880	COG1011	Hydrolase
HYG85_20885	COG1247	-acetyltransferase
HYG85_20895	COG3266	domain, Protein
HYG85_20895	COG2911	Protein conserved in bacteria
HYG85_20895	COG1361	Conserved repeat domain
HYG85_20915	COG0733	neurotransmitter:sodium symporter activity
HYG85_20920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYG85_20940	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYG85_20945	COG1793	dna ligase
HYG85_20950	COG1793	dna ligase
HYG85_20950	COG3285	dna ligase
HYG85_20955	COG3287	FIST C domain
HYG85_20955	COG2199	diguanylate cyclase activity
HYG85_20955	COG2200	EAL domain
HYG85_20960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYG85_20965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYG85_20980	COG0840	transmembrane signaling receptor activity
HYG85_21010	COG2197	response regulator
HYG85_21015	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_21020	COG0546	phosphoglycolate phosphatase activity
HYG85_21040	COG0488	(ABC) transporter
HYG85_21055	COG0577	efflux transmembrane transporter activity
HYG85_21060	COG1136	(ABC) transporter
HYG85_21075	COG2323	membrane
HYG85_21090	COG0697	spore germination
HYG85_21105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYG85_21110	COG0509	glycine decarboxylation via glycine cleavage system
HYG85_21115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG85_21120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG85_21125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG85_21130	COG1522	sequence-specific DNA binding
HYG85_21140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG85_21150	COG2115	Belongs to the xylose isomerase family
HYG85_21160	COG1070	Carbohydrate kinase
HYG85_21190	COG1193	negative regulation of DNA recombination
HYG85_21195	COG2315	Protein conserved in bacteria
HYG85_21210	COG0668	transmembrane transport
HYG85_21215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYG85_21240	COG0539	negative regulation of cytoplasmic translation
HYG85_21300	COG0393	Putative heavy-metal-binding
HYG85_21315	COG0745	RESPONSE REGULATOR receiver
HYG85_21320	COG2205	protein histidine kinase activity
HYG85_21330	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYG85_21335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYG85_21340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYG85_21350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG85_21360	COG4209	transmembrane transport
HYG85_21365	COG0395	ABC-type sugar transport system, permease component
HYG85_21370	COG1653	transport
HYG85_21375	COG3250	beta-galactosidase activity
HYG85_21390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG85_21390	COG2207	Transcriptional regulator
HYG85_21395	COG2972	Histidine kinase
HYG85_21400	COG4209	transmembrane transport
HYG85_21405	COG0395	ABC-type sugar transport system, permease component
HYG85_21410	COG1653	transport
HYG85_21435	COG1501	Belongs to the glycosyl hydrolase 31 family
HYG85_21440	COG1917	Cupin 2, conserved barrel domain protein
HYG85_21440	COG2207	Transcriptional regulator
HYG85_21445	COG0789	Transcriptional regulator
HYG85_21445	COG4978	Transcriptional regulator
HYG85_21450	COG0534	Mate efflux family protein
HYG85_21460	COG1917	Cupin 2, conserved barrel domain protein
HYG85_21460	COG4977	sequence-specific DNA binding
HYG85_21485	COG1396	sequence-specific DNA binding
HYG85_21535	COG1378	Sugar-specific transcriptional regulator TrmB
HYG85_21550	COG0726	polysaccharide deacetylase
HYG85_21570	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HYG85_21580	COG0409	Hydrogenase expression formation protein
HYG85_21595	COG3119	arylsulfatase activity
HYG85_21600	COG2186	Transcriptional regulator
HYG85_21605	COG0129	dihydroxy-acid dehydratase activity
HYG85_21640	COG2972	Histidine kinase
HYG85_21640	COG0745	RESPONSE REGULATOR receiver
HYG85_21650	COG2207	Transcriptional regulator
HYG85_21660	COG4209	transmembrane transport
HYG85_21665	COG0395	ABC-type sugar transport system, permease component
HYG85_21685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYG85_21700	COG0714	Associated with various cellular activities
HYG85_21715	COG2304	oxidoreductase activity
HYG85_21745	COG0745	RESPONSE REGULATOR receiver
HYG85_21765	COG0012	GTP binding
HYG85_21785	COG2001	Belongs to the MraZ family
HYG85_21790	COG0275	rRNA processing
HYG85_21800	COG0768	penicillin binding
HYG85_21805	COG0768	penicillin binding
HYG85_21810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG85_21815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG85_21820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG85_21825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYG85_21830	COG0772	Belongs to the SEDS family
HYG85_21835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG85_21845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYG85_21855	COG1191	sigma factor activity
HYG85_21860	COG1191	sigma factor activity
HYG85_21870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG85_21880	COG0606	chelatase, subunit chli
HYG85_21885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYG85_21890	COG2348	transferase activity, transferring amino-acyl groups
HYG85_21895	COG0758	DNA mediated transformation
HYG85_21900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYG85_21910	COG1815	bacterial-type flagellum-dependent cell motility
HYG85_21920	COG1677	Flagellar hook-basal body complex protein FliE
HYG85_21925	COG1766	The M ring may be actively involved in energy transduction
HYG85_21930	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG85_21940	COG1157	protein secretion by the type III secretion system
HYG85_21955	COG3144	bacterial-type flagellum assembly
HYG85_21960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYG85_21985	COG1360	Flagellar Motor Protein
HYG85_21995	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG85_22000	COG1776	CheC inhibitor of MCP methylation
HYG85_22000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG85_22005	COG2201	protein-glutamate methylesterase activity
HYG85_22015	COG1338	Plays a role in the flagellum-specific transport system
HYG85_22020	COG1987	bacterial-type flagellum assembly
HYG85_22025	COG1684	flagellar biosynthetic protein fliR
HYG85_22030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG85_22035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG85_22040	COG1419	protein localization to endoplasmic reticulum
HYG85_22055	COG2201	protein-glutamate methylesterase activity
HYG85_22060	COG2198	Histidine kinase
HYG85_22060	COG0643	Histidine kinase
HYG85_22070	COG1776	CheC inhibitor of MCP methylation
HYG85_22075	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HYG85_22085	COG1191	sigma factor activity
HYG85_22110	COG0052	Belongs to the universal ribosomal protein uS2 family
HYG85_22115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYG85_22120	COG0528	UMP kinase activity
HYG85_22125	COG0233	cytoplasmic translational termination
HYG85_22130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYG85_22135	COG0575	Belongs to the CDS family
HYG85_22140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYG85_22145	COG0750	zinc metalloprotease
HYG85_22150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYG85_22160	COG0733	neurotransmitter:sodium symporter activity
HYG85_22170	COG0328	RNA-DNA hybrid ribonuclease activity
HYG85_22180	COG2357	RelA SpoT domain protein
HYG85_22190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HYG85_22190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG85_22195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYG85_22215	COG1028	Short-chain dehydrogenase reductase Sdr
HYG85_22230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG85_22235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG85_22240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG85_22255	COG1082	Xylose isomerase domain protein TIM barrel
HYG85_22260	COG1461	Dihydroxyacetone kinase
HYG85_22265	COG2376	Dihydroxyacetone kinase
HYG85_22290	COG1550	Protein conserved in bacteria
HYG85_22295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG85_22315	COG2972	Histidine kinase
HYG85_22320	COG2207	Transcriptional regulator
HYG85_22320	COG4753	response regulator
HYG85_22325	COG3250	beta-galactosidase activity
HYG85_22340	COG2207	Transcriptional regulator
HYG85_22340	COG4753	response regulator
HYG85_22355	COG0351	phosphomethylpyrimidine kinase
HYG85_22360	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HYG85_22365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HYG85_22375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG85_22385	COG0564	pseudouridine synthase activity
HYG85_22390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG85_22395	COG3331	DNA recombination
HYG85_22400	COG0124	histidyl-tRNA synthetase
HYG85_22405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYG85_22410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYG85_22415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG85_22420	COG0131	Imidazoleglycerol-phosphate dehydratase
HYG85_22425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HYG85_22430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HYG85_22435	COG0107	imidazoleglycerol-phosphate synthase activity
HYG85_22450	COG1160	GTP binding
HYG85_22460	COG2172	sigma factor antagonist activity
HYG85_22480	COG4656	Part of a membrane complex involved in electron transport
HYG85_22485	COG4658	electron transport chain
HYG85_22490	COG4659	FMN binding
HYG85_22495	COG4660	Part of a membrane complex involved in electron transport
HYG85_22500	COG4657	Part of a membrane complex involved in electron transport
HYG85_22505	COG2878	Part of a membrane complex involved in electron transport
HYG85_22505	COG1245	4Fe-4S binding domain
HYG85_22515	COG0424	maF-like protein
HYG85_22520	COG2003	Belongs to the UPF0758 family
HYG85_22525	COG1077	Cell shape determining protein MreB Mrl
HYG85_22540	COG0768	penicillin binding
HYG85_22550	COG2894	cell division
HYG85_22555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HYG85_22560	COG0772	Belongs to the SEDS family
HYG85_22565	COG1803	Methylglyoxal synthase
HYG85_22575	COG2155	Conserved Protein
HYG85_22590	COG0346	lactoylglutathione lyase activity
HYG85_22600	COG1846	Transcriptional regulator
HYG85_22620	COG1331	Highly conserved protein containing a thioredoxin domain
HYG85_22630	COG2972	Histidine kinase
HYG85_22635	COG2207	Transcriptional regulator
HYG85_22640	COG1653	transport
HYG85_22645	COG4209	transmembrane transport
HYG85_22650	COG0395	ABC-type sugar transport system, permease component
HYG85_22675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYG85_22680	COG1799	cell septum assembly
HYG85_22685	COG0762	integral membrane protein
HYG85_22700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYG85_22710	COG0564	pseudouridine synthase activity
HYG85_22720	COG4974	Belongs to the 'phage' integrase family
HYG85_22745	COG2205	protein histidine kinase activity
HYG85_22755	COG0187	DNA topoisomerase II activity
HYG85_22760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG85_22785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG85_22795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYG85_22800	COG2233	PERMEase
HYG85_22805	COG3858	chitin binding
HYG85_22810	COG0540	Belongs to the ATCase OTCase family
HYG85_22815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYG85_22850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG85_22855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG85_22860	COG1120	ATPase activity
HYG85_22865	COG2267	carboxylic ester hydrolase activity
HYG85_22875	COG0534	Mate efflux family protein
HYG85_22890	COG1129	ABC transporter
HYG85_22895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_22900	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_22905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HYG85_22910	COG0697	spore germination
HYG85_22920	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG85_22940	COG2972	Histidine kinase
HYG85_22945	COG2197	response regulator
HYG85_22955	COG1175	transmembrane transport
HYG85_22960	COG0395	ABC-type sugar transport system, permease component
HYG85_22980	COG3507	Belongs to the glycosyl hydrolase 43 family
HYG85_22990	COG0037	tRNA processing
HYG85_22995	COG4974	Belongs to the 'phage' integrase family
HYG85_23005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG85_23010	COG1713	HD superfamily hydrolase involved in NAD metabolism
HYG85_23015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYG85_23030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYG85_23035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYG85_23050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYG85_23055	COG1530	ribonuclease E activity
HYG85_23075	COG0367	asparagine synthase
HYG85_23080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYG85_23090	COG0730	response to heat
HYG85_23095	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG85_23100	COG2848	UPF0210 protein
HYG85_23110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYG85_23120	COG0849	cell division
HYG85_23130	COG0237	dephospho-CoA kinase activity
HYG85_23135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG85_23135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG85_23145	COG1595	DNA-templated transcription, initiation
HYG85_23170	COG0402	S-adenosylhomocysteine deaminase activity
HYG85_23180	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG85_23195	COG2080	2 iron, 2 sulfur cluster binding
HYG85_23200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYG85_23205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYG85_23210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYG85_23215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG85_23225	COG0402	S-adenosylhomocysteine deaminase activity
HYG85_23230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG85_23230	COG0493	'glutamate synthase
HYG85_23240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYG85_23240	COG3608	succinylglutamate desuccinylase aspartoacylase
HYG85_23245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYG85_23250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG85_23260	COG3608	succinylglutamate desuccinylase aspartoacylase
HYG85_23260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYG85_23265	COG2348	transferase activity, transferring amino-acyl groups
HYG85_23280	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG85_23300	COG0768	penicillin binding
HYG85_23310	COG0826	peptidase U32
HYG85_23325	COG2255	four-way junction helicase activity
HYG85_23330	COG0632	four-way junction helicase activity
HYG85_23335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYG85_23335	COG0723	plastoquinol--plastocyanin reductase activity
HYG85_23350	COG1051	belongs to the nudix hydrolase family
HYG85_23365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYG85_23370	COG4224	UPF0291 protein
HYG85_23385	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HYG85_23415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYG85_23425	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HYG85_23430	COG2081	HI0933 family
HYG85_23445	COG0728	peptidoglycan biosynthetic process
HYG85_23450	COG0295	cytidine deaminase activity
HYG85_23455	COG1470	cell adhesion involved in biofilm formation
HYG85_23460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYG85_23465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYG85_23475	COG1702	phosphate starvation-inducible protein PhoH
HYG85_23490	COG1610	YqeY-like protein
HYG85_23495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYG85_23505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG85_23530	COG0456	acetyltransferase
HYG85_23545	COG0246	Mannitol dehydrogenase
HYG85_23550	COG2721	sulfolactate sulfo-lyase activity
HYG85_23555	COG0157	Belongs to the NadC ModD family
HYG85_23565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYG85_23575	COG2197	response regulator
HYG85_23580	COG2972	Histidine kinase
HYG85_23600	COG1129	ABC transporter
HYG85_23615	COG1131	(ABC) transporter
HYG85_23640	COG0714	Associated with various cellular activities
HYG85_23650	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HYG85_23655	COG1923	regulation of RNA biosynthetic process
HYG85_23660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYG85_23670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG85_23675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG85_23690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYG85_23695	COG0539	negative regulation of cytoplasmic translation
HYG85_23695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG85_23700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG85_23705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYG85_23715	COG2081	HI0933 family
HYG85_23720	COG1737	Transcriptional regulator
HYG85_23730	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HYG85_23735	COG4770	biotin carboxylase activity
HYG85_23745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYG85_23750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYG85_23755	COG1187	pseudouridine synthase activity
HYG85_23760	COG1686	Belongs to the peptidase S11 family
HYG85_23765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYG85_23770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYG85_23795	COG3682	Transcriptional regulator
HYG85_23800	COG3266	domain, Protein
HYG85_23800	COG1361	Conserved repeat domain
HYG85_23800	COG2911	Protein conserved in bacteria
HYG85_23805	COG0280	phosphate acetyltransferase
HYG85_23810	COG3426	butyrate kinase activity
HYG85_23815	COG2207	Transcriptional regulator
HYG85_23820	COG1686	Belongs to the peptidase S11 family
HYG85_23830	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYG85_23845	COG1773	rubredoxin
HYG85_23845	COG1592	Rubrerythrin
HYG85_23905	COG2201	protein-glutamate methylesterase activity
HYG85_23910	COG2972	Histidine kinase
HYG85_23920	COG1129	ABC transporter
HYG85_23925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG85_23930	COG3858	chitin binding
HYG85_23940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYG85_23955	COG4974	Belongs to the 'phage' integrase family
HYG85_23970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYG85_23975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYG85_23985	COG2359	stage V sporulation protein S
HYG85_23990	COG1418	mRNA catabolic process
HYG85_23995	COG2137	regulation of response to DNA damage stimulus
HYG85_24005	COG1058	Belongs to the CinA family
HYG85_24005	COG1546	Belongs to the CinA family
HYG85_24015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG85_24020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYG85_24030	COG1674	ftsk spoiiie
HYG85_24035	COG1968	undecaprenyl-diphosphatase activity
HYG85_24045	COG0740	serine-type endopeptidase activity
HYG85_24050	COG0527	aspartate kinase activity
HYG85_24055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG85_24070	COG4948	Mandelate Racemase Muconate Lactonizing
HYG85_24075	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYG85_24080	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HYG85_24090	COG0640	Transcriptional regulator
HYG85_24115	COG4555	ABC transporter
HYG85_24125	COG0667	Aldo Keto reductase
HYG85_24135	COG0612	Peptidase, M16
HYG85_24140	COG1185	polyribonucleotide nucleotidyltransferase activity
HYG85_24145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYG85_24150	COG0196	riboflavin kinase activity
HYG85_24155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYG85_24160	COG2404	hydrolase activity, acting on ester bonds
HYG85_24165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYG85_24170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYG85_24180	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HYG85_24185	COG0195	Participates in both transcription termination and antitermination
HYG85_24190	COG0779	Required for maturation of 30S ribosomal subunits
HYG85_24195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat