locus-tag	class	description
HZI73_00070	COG0582	viral genome integration into host DNA
HZI73_00075	COG0588	phosphoglycerate mutase activity
HZI73_00105	COG0745	RESPONSE REGULATOR receiver
HZI73_00110	COG1278	Cold shock
HZI73_00130	COG0697	spore germination
HZI73_00150	COG1454	alcohol dehydrogenase
HZI73_00155	COG2207	Transcriptional regulator
HZI73_00160	COG1671	Belongs to the UPF0178 family
HZI73_00170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZI73_00180	COG0037	tRNA processing
HZI73_00185	COG2208	phosphoserine phosphatase activity
HZI73_00205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZI73_00210	COG0776	regulation of translation
HZI73_00215	COG3956	TIGRFAM MazG family protein
HZI73_00220	COG2002	toxin-antitoxin pair type II binding
HZI73_00230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZI73_00235	COG0193	aminoacyl-tRNA hydrolase activity
HZI73_00255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZI73_00260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZI73_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZI73_00270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZI73_00280	COG1484	DNA-dependent DNA replication
HZI73_00315	COG4717	serine-type aminopeptidase activity
HZI73_00325	COG0205	6-phosphofructokinase activity
HZI73_00335	COG0484	heat shock protein binding
HZI73_00345	COG2188	Transcriptional regulator
HZI73_00355	COG2226	methyltransferase
HZI73_00360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZI73_00370	COG1363	Peptidase, m42
HZI73_00375	COG0668	transmembrane transport
HZI73_00385	COG0017	Asparaginyl-tRNA synthetase
HZI73_00420	COG1132	(ABC) transporter
HZI73_00425	COG1132	(ABC) transporter
HZI73_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZI73_00490	COG1132	(ABC) transporter
HZI73_00495	COG1132	(ABC) transporter
HZI73_00520	COG2226	methyltransferase
HZI73_00545	COG0519	Catalyzes the synthesis of GMP from XMP
HZI73_00570	COG0210	DNA helicase
HZI73_00575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZI73_00610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZI73_00615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZI73_00620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZI73_00625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZI73_00630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZI73_00635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZI73_00665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HZI73_00675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZI73_00685	COG0698	ribose 5-phosphate isomerase
HZI73_00690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZI73_00695	COG0009	L-threonylcarbamoyladenylate synthase
HZI73_00705	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZI73_00720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HZI73_00720	COG2199	diguanylate cyclase activity
HZI73_00735	COG0631	protein serine/threonine phosphatase activity
HZI73_00785	COG0305	Participates in initiation and elongation during chromosome replication
HZI73_00790	COG0359	binds to the 23S rRNA
HZI73_00795	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HZI73_00810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZI73_00815	COG0629	single-stranded DNA binding
HZI73_00820	COG0360	Binds together with S18 to 16S ribosomal RNA
HZI73_00825	COG4481	Protein conserved in bacteria
HZI73_00915	COG3949	Membrane
HZI73_00920	COG0297	glycogen (starch) synthase activity
HZI73_00930	COG1733	regulation of RNA biosynthetic process
HZI73_00935	COG1164	Oligoendopeptidase f
HZI73_00940	COG4806	L-rhamnose isomerase
HZI73_00945	COG1070	Carbohydrate kinase
HZI73_00955	COG2207	Transcriptional regulator
HZI73_00975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZI73_00990	COG1501	Belongs to the glycosyl hydrolase 31 family
HZI73_01000	COG0395	ABC-type sugar transport system, permease component
HZI73_01005	COG1175	transmembrane transport
HZI73_01010	COG1609	Transcriptional regulator
HZI73_01040	COG1489	DNA binding
HZI73_01065	COG2972	Histidine kinase
HZI73_01075	COG0395	ABC-type sugar transport system, permease component
HZI73_01080	COG4209	transmembrane transport
HZI73_01090	COG0745	RESPONSE REGULATOR receiver
HZI73_01095	COG5002	protein histidine kinase activity
HZI73_01105	COG1131	(ABC) transporter
HZI73_01115	COG0840	transmembrane signaling receptor activity
HZI73_01135	COG1595	DNA-templated transcription, initiation
HZI73_01150	COG1827	regulation of RNA biosynthetic process
HZI73_01155	COG0166	Belongs to the GPI family
HZI73_01160	COG0726	polysaccharide deacetylase
HZI73_01200	COG3852	Histidine kinase
HZI73_01220	COG0596	Alpha beta hydrolase
HZI73_01220	COG2945	thiolester hydrolase activity
HZI73_01230	COG2132	Multicopper oxidase
HZI73_01235	COG0825	malonyl-CoA metabolic process
HZI73_01240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZI73_01245	COG0439	Biotin carboxylase
HZI73_01255	COG0511	ligase activity, forming carbon-carbon bonds
HZI73_01260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZI73_01270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZI73_01275	COG2070	2-Nitropropane dioxygenase
HZI73_01285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZI73_01290	COG1695	Transcriptional regulator
HZI73_01305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZI73_01315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZI73_01320	COG0084	hydrolase, TatD family'
HZI73_01325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZI73_01325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZI73_01340	COG0395	ABC-type sugar transport system, permease component
HZI73_01345	COG4209	transmembrane transport
HZI73_01355	COG2207	Transcriptional regulator
HZI73_01360	COG3119	arylsulfatase activity
HZI73_01365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZI73_01370	COG0673	inositol 2-dehydrogenase activity
HZI73_01390	COG3119	arylsulfatase activity
HZI73_01395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZI73_01400	COG1882	Formate acetyltransferase
HZI73_01410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_01470	COG3119	arylsulfatase activity
HZI73_01500	COG1217	gtp-binding protein TYPA
HZI73_01515	COG1846	Transcriptional regulator
HZI73_01525	COG2715	membrane protein required for spore maturation
HZI73_01540	COG1131	(ABC) transporter
HZI73_01555	COG1760	l-serine dehydratase
HZI73_01560	COG1760	l-serine dehydratase
HZI73_01565	COG2002	toxin-antitoxin pair type II binding
HZI73_01570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZI73_01575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HZI73_01580	COG1774	PSP1 C-terminal conserved region
HZI73_01585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZI73_01595	COG3870	Protein conserved in bacteria
HZI73_01600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZI73_01605	COG1982	Orn Lys Arg decarboxylase major
HZI73_01665	COG1079	Belongs to the binding-protein-dependent transport system permease family
HZI73_01670	COG4603	Belongs to the binding-protein-dependent transport system permease family
HZI73_01675	COG3845	ABC transporter
HZI73_01680	COG1744	ABC transporter substrate-binding protein PnrA-like
HZI73_01705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZI73_01710	COG0187	DNA topoisomerase II activity
HZI73_01715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZI73_01730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZI73_01735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HZI73_01740	COG0594	ribonuclease P activity
HZI73_01745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZI73_01755	COG1847	R3H domain protein
HZI73_01760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZI73_01765	COG0445	tRNA wobble uridine modification
HZI73_01770	COG0357	Ribosomal RNA small subunit methyltransferase G
HZI73_01785	COG0697	spore germination
HZI73_01800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZI73_01810	COG0157	Belongs to the NadC ModD family
HZI73_01830	COG0018	arginyl-trna synthetase
HZI73_01835	COG1192	Involved in chromosome partitioning
HZI73_01840	COG1475	DNA binding
HZI73_01855	COG0561	phosphatase activity
HZI73_01860	COG1454	alcohol dehydrogenase
HZI73_01860	COG1012	belongs to the aldehyde dehydrogenase family
HZI73_01870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZI73_01880	COG2873	o-acetylhomoserine
HZI73_01890	COG2234	aminopeptidase activity
HZI73_01895	COG4294	response to UV
HZI73_01900	COG1533	DNA photolyase activity
HZI73_01905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZI73_01910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZI73_01940	COG3033	Beta-eliminating lyase
HZI73_01945	COG2340	Cysteine-rich secretory protein family
HZI73_01950	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HZI73_01960	COG0745	RESPONSE REGULATOR receiver
HZI73_01965	COG5002	protein histidine kinase activity
HZI73_01970	COG1136	(ABC) transporter
HZI73_02000	COG3153	acetyltransferase
HZI73_02010	COG0469	pyruvate kinase activity
HZI73_02040	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HZI73_02045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZI73_02070	COG3118	belongs to the thioredoxin family
HZI73_02075	COG0628	permease
HZI73_02080	COG0840	transmembrane signaling receptor activity
HZI73_02085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZI73_02090	COG1309	transcriptional regulator
HZI73_02100	COG1349	DNA-binding transcription factor activity
HZI73_02125	COG1129	ABC transporter
HZI73_02130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_02135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_02145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZI73_02155	COG0183	Belongs to the thiolase family
HZI73_02165	COG0673	inositol 2-dehydrogenase activity
HZI73_02170	COG1435	thymidine kinase activity
HZI73_02180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZI73_02190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZI73_02205	COG1695	Transcriptional regulator
HZI73_02215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZI73_02220	COG5658	integral membrane protein
HZI73_02225	COG1609	Transcriptional regulator
HZI73_02235	COG1175	transmembrane transport
HZI73_02240	COG3833	ABC-type maltose transport systems, permease component
HZI73_02245	COG0366	Alpha amylase catalytic
HZI73_02250	COG0366	Alpha amylase catalytic
HZI73_02255	COG1609	Transcriptional regulator
HZI73_02270	COG1175	transmembrane transport
HZI73_02275	COG0395	ABC-type sugar transport system, permease component
HZI73_02295	COG1175	transmembrane transport
HZI73_02300	COG3833	ABC-type maltose transport systems, permease component
HZI73_02305	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_02320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZI73_02335	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZI73_02345	COG3250	beta-galactosidase activity
HZI73_02350	COG0488	(ABC) transporter
HZI73_02365	COG0347	Belongs to the P(II) protein family
HZI73_02370	COG0004	ammonium transporteR
HZI73_02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZI73_02390	COG1191	sigma factor activity
HZI73_02400	COG2373	Large extracellular alpha-helical protein
HZI73_02405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZI73_02420	COG0697	spore germination
HZI73_02435	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HZI73_02440	COG2972	Histidine kinase
HZI73_02445	COG2207	Transcriptional regulator
HZI73_02445	COG4753	response regulator
HZI73_02455	COG1175	transmembrane transport
HZI73_02460	COG0395	ABC-type sugar transport system, permease component
HZI73_02465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZI73_02505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZI73_02520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZI73_02555	COG1136	(ABC) transporter
HZI73_02560	COG0577	efflux transmembrane transporter activity
HZI73_02560	COG1136	(ABC) transporter
HZI73_02570	COG5002	protein histidine kinase activity
HZI73_02570	COG3850	Histidine kinase
HZI73_02610	COG0124	histidyl-tRNA synthetase
HZI73_02620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_02650	COG2221	Nitrite and sulphite reductase 4Fe-4S
HZI73_02655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZI73_02665	COG2188	Transcriptional regulator
HZI73_02680	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZI73_02685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZI73_02700	COG2373	Large extracellular alpha-helical protein
HZI73_02750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZI73_02760	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZI73_02765	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZI73_02770	COG0457	Tetratricopeptide repeat
HZI73_02770	COG0705	Rhomboid family
HZI73_02795	COG3852	Histidine kinase
HZI73_02800	COG0537	adenosine 5'-monophosphoramidase activity
HZI73_02805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZI73_02810	COG1609	Transcriptional regulator
HZI73_02820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZI73_02825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZI73_02830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HZI73_02840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZI73_02880	COG0739	heme binding
HZI73_02885	COG0745	RESPONSE REGULATOR receiver
HZI73_02890	COG5002	protein histidine kinase activity
HZI73_02950	COG3850	Histidine kinase
HZI73_02950	COG5002	protein histidine kinase activity
HZI73_02965	COG1595	DNA-templated transcription, initiation
HZI73_03030	COG0697	spore germination
HZI73_03040	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_03075	COG1309	transcriptional regulator
HZI73_03115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZI73_03120	COG0745	RESPONSE REGULATOR receiver
HZI73_03125	COG0628	permease
HZI73_03150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZI73_03155	COG1174	glycine betaine transport
HZI73_03175	COG0463	Glycosyl transferase, family 2
HZI73_03180	COG2246	polysaccharide biosynthetic process
HZI73_03200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZI73_03205	COG0463	Glycosyl transferase, family 2
HZI73_03225	COG1131	(ABC) transporter
HZI73_03245	COG0251	oxidation-reduction process
HZI73_03250	COG3681	Belongs to the UPF0597 family
HZI73_03260	COG4555	ABC transporter
HZI73_03270	COG1482	cell wall glycoprotein biosynthetic process
HZI73_03275	COG0617	tRNA 3'-terminal CCA addition
HZI73_03320	COG3842	ATPase activity
HZI73_03335	COG2972	Histidine kinase
HZI73_03340	COG2207	Transcriptional regulator
HZI73_03340	COG4753	response regulator
HZI73_03345	COG1309	transcriptional regulator
HZI73_03350	COG3848	Pyruvate phosphate dikinase
HZI73_03350	COG0574	Belongs to the PEP-utilizing enzyme family
HZI73_03355	COG1309	transcriptional regulator
HZI73_03360	COG1309	transcriptional regulator
HZI73_03395	COG0436	Aminotransferase
HZI73_03410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZI73_03420	COG4466	Protein conserved in bacteria
HZI73_03430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZI73_03435	COG1802	Transcriptional regulator
HZI73_03450	COG0697	spore germination
HZI73_03480	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZI73_03495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZI73_03505	COG3290	protein histidine kinase activity
HZI73_03525	COG0793	Belongs to the peptidase S41A family
HZI73_03530	COG0504	CTP synthase activity
HZI73_03550	COG1640	4-alpha-glucanotransferase
HZI73_03565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZI73_03575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZI73_03580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZI73_03595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZI73_03605	COG0058	SHG alpha-glucan phosphorylase activity
HZI73_03610	COG2972	Histidine kinase
HZI73_03615	COG2207	Transcriptional regulator
HZI73_03615	COG4753	response regulator
HZI73_03620	COG1175	transmembrane transport
HZI73_03625	COG0395	ABC-type sugar transport system, permease component
HZI73_03640	COG2385	sporulation resulting in formation of a cellular spore
HZI73_03655	COG1720	tRNA m6t6A37 methyltransferase activity
HZI73_03665	COG2207	Transcriptional regulator
HZI73_03665	COG3708	Transcriptional regulator
HZI73_03675	COG1609	Transcriptional regulator
HZI73_03680	COG1077	Cell shape determining protein MreB Mrl
HZI73_03685	COG4786	Flagellar basal body rod
HZI73_03710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZI73_03715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZI73_03720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZI73_03735	COG3418	PFAM FlgN family protein
HZI73_03740	COG1256	bacterial-type flagellum assembly
HZI73_03740	COG4786	Flagellar basal body rod
HZI73_03750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZI73_03755	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HZI73_03760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZI73_03775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZI73_03780	COG1516	flagellar protein fliS
HZI73_03800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZI73_03810	COG0250	Participates in transcription elongation, termination and antitermination
HZI73_03815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZI73_03820	COG0081	regulation of translation
HZI73_03830	COG0222	ribosome binding
HZI73_03835	COG0085	RNA polymerase activity
HZI73_03840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZI73_03845	COG1358	cellular component organization or biogenesis
HZI73_03850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZI73_03855	COG0049	tRNA binding
HZI73_03860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZI73_03865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZI73_03870	COG0051	transcription antitermination factor activity, RNA binding
HZI73_03875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZI73_03890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZI73_03900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZI73_03910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZI73_03915	COG0255	Belongs to the universal ribosomal protein uL29 family
HZI73_03920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZI73_03935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZI73_03940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZI73_03945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZI73_03950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZI73_03955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZI73_03960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZI73_03965	COG1841	ribosomal large subunit assembly
HZI73_03970	COG0200	Binds to the 23S rRNA
HZI73_03975	COG0201	protein transport
HZI73_03980	COG0563	adenylate kinase activity
HZI73_03995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZI73_04000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZI73_04005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZI73_04010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZI73_04015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZI73_04020	COG0202	RNA polymerase activity
HZI73_04025	COG0203	ribosomal protein L17
HZI73_04040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZI73_04055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZI73_04060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZI73_04090	COG0840	transmembrane signaling receptor activity
HZI73_04105	COG1773	rubredoxin
HZI73_04110	COG1609	Transcriptional regulator
HZI73_04115	COG0673	inositol 2-dehydrogenase activity
HZI73_04120	COG1082	Xylose isomerase domain protein TIM barrel
HZI73_04125	COG0673	inositol 2-dehydrogenase activity
HZI73_04135	COG0840	transmembrane signaling receptor activity
HZI73_04145	COG1131	(ABC) transporter
HZI73_04150	COG1725	Transcriptional regulator
HZI73_04160	COG0426	domain, Protein
HZI73_04165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZI73_04170	COG0569	domain protein
HZI73_04175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZI73_04195	COG1368	sulfuric ester hydrolase activity
HZI73_04200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZI73_04205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZI73_04230	COG3437	response regulator, receiver
HZI73_04235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZI73_04260	COG4152	abc transporter atp-binding protein
HZI73_04265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HZI73_04265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HZI73_04285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZI73_04290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZI73_04300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZI73_04305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZI73_04385	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZI73_04395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZI73_04435	COG4977	sequence-specific DNA binding
HZI73_04465	COG1309	transcriptional regulator
HZI73_04500	COG2972	Histidine kinase
HZI73_04505	COG2207	Transcriptional regulator
HZI73_04505	COG4753	response regulator
HZI73_04515	COG4209	transmembrane transport
HZI73_04520	COG0395	ABC-type sugar transport system, permease component
HZI73_04530	COG3250	beta-galactosidase activity
HZI73_04540	COG3250	beta-galactosidase activity
HZI73_04545	COG3119	arylsulfatase activity
HZI73_04550	COG4443	Transcriptional Coactivator p15 (PC4)
HZI73_04555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZI73_04570	COG0494	nUDIX hydrolase
HZI73_04580	COG2186	Transcriptional regulator
HZI73_04590	COG0840	transmembrane signaling receptor activity
HZI73_04605	COG0640	Transcriptional regulator
HZI73_04610	COG0798	PFAM Bile acid sodium symporter
HZI73_04620	COG2207	Transcriptional regulator
HZI73_04635	COG4209	transmembrane transport
HZI73_04640	COG0395	ABC-type sugar transport system, permease component
HZI73_04645	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_04670	COG1136	(ABC) transporter
HZI73_04695	COG1136	(ABC) transporter
HZI73_04695	COG0577	efflux transmembrane transporter activity
HZI73_04705	COG0577	efflux transmembrane transporter activity
HZI73_04705	COG1136	(ABC) transporter
HZI73_04720	COG1151	hydroxylamine reductase activity
HZI73_04735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZI73_04740	COG1501	Belongs to the glycosyl hydrolase 31 family
HZI73_04745	COG1609	Transcriptional regulator
HZI73_04750	COG2602	Beta-lactamase
HZI73_04760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZI73_04765	COG3275	phosphorelay sensor kinase activity
HZI73_04770	COG4753	response regulator
HZI73_04770	COG2207	Transcriptional regulator
HZI73_04775	COG4209	transmembrane transport
HZI73_04780	COG0395	ABC-type sugar transport system, permease component
HZI73_04790	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_04800	COG2755	lipolytic protein G-D-S-L family
HZI73_04800	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZI73_04815	COG1595	DNA-templated transcription, initiation
HZI73_04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZI73_04910	COG2226	methyltransferase
HZI73_04920	COG2207	Transcriptional regulator
HZI73_04920	COG3708	Transcriptional regulator
HZI73_04930	COG5002	protein histidine kinase activity
HZI73_04975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZI73_04980	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZI73_05010	COG1842	Phage shock protein A
HZI73_05025	COG1349	DNA-binding transcription factor activity
HZI73_05050	COG1166	arginine decarboxylase activity
HZI73_05055	COG0010	Belongs to the arginase family
HZI73_05075	COG2339	peptidase activity
HZI73_05090	COG1940	carbohydrate kinase activity
HZI73_05105	COG0622	Phosphoesterase
HZI73_05115	COG0116	Belongs to the methyltransferase superfamily
HZI73_05140	COG1252	NADH dehydrogenase
HZI73_05155	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZI73_05160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZI73_05165	COG0163	prenyltransferase activity
HZI73_05170	COG1116	anion transmembrane transporter activity
HZI73_05175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_05180	COG3976	FMN-binding domain protein
HZI73_05180	COG1053	succinate dehydrogenase
HZI73_05185	COG3290	protein histidine kinase activity
HZI73_05200	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZI73_05205	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZI73_05215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZI73_05220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZI73_05265	COG2954	triphosphatase activity
HZI73_05275	COG4166	transmembrane transport
HZI73_05280	COG0601	transmembrane transport
HZI73_05285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_05290	COG0444	Belongs to the ABC transporter superfamily
HZI73_05295	COG4608	Belongs to the ABC transporter superfamily
HZI73_05335	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZI73_05340	COG0740	serine-type endopeptidase activity
HZI73_05345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZI73_05350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZI73_05355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZI73_05365	COG1242	4 iron, 4 sulfur cluster binding
HZI73_05375	COG5658	integral membrane protein
HZI73_05380	COG0640	Transcriptional regulator
HZI73_05385	COG0281	malic enzyme
HZI73_05390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZI73_05425	COG0789	Transcriptional regulator
HZI73_05430	COG2972	Histidine kinase
HZI73_05430	COG0745	RESPONSE REGULATOR receiver
HZI73_05435	COG3279	Response regulator of the LytR AlgR family
HZI73_05450	COG1309	transcriptional regulator
HZI73_05460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZI73_05465	COG1609	Transcriptional regulator
HZI73_05475	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_05485	COG1175	transmembrane transport
HZI73_05490	COG0395	ABC-type sugar transport system, permease component
HZI73_05495	COG1605	Chorismate mutase
HZI73_05495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZI73_05515	COG0842	Transport permease protein
HZI73_05525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZI73_05530	COG1120	ATPase activity
HZI73_05535	COG1797	cobyrinic acid a,c-diamide synthase activity
HZI73_05555	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HZI73_05590	COG2207	Transcriptional regulator
HZI73_05590	COG3708	Transcriptional regulator
HZI73_05625	COG5002	protein histidine kinase activity
HZI73_05630	COG1136	(ABC) transporter
HZI73_05630	COG0577	efflux transmembrane transporter activity
HZI73_05635	COG0577	efflux transmembrane transporter activity
HZI73_05670	COG3177	Filamentation induced by cAMP protein fic
HZI73_05700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZI73_05710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZI73_05715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZI73_05720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZI73_05725	COG1794	racemase activity, acting on amino acids and derivatives
HZI73_05730	COG1968	undecaprenyl-diphosphatase activity
HZI73_05735	COG0250	Participates in transcription elongation, termination and antitermination
HZI73_05740	COG1605	Chorismate mutase
HZI73_05740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZI73_05770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZI73_05775	COG2192	nodulation
HZI73_05835	COG1819	glycosyl
HZI73_05890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZI73_05900	COG1032	radical SAM domain protein
HZI73_05910	COG3848	Pyruvate phosphate dikinase
HZI73_05910	COG0574	Belongs to the PEP-utilizing enzyme family
HZI73_05920	COG1032	radical SAM domain protein
HZI73_05925	COG1032	radical SAM domain protein
HZI73_05955	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_05960	COG2199	diguanylate cyclase activity
HZI73_05975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZI73_05985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZI73_06010	COG0183	Belongs to the thiolase family
HZI73_06015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZI73_06020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZI73_06045	COG1309	transcriptional regulator
HZI73_06055	COG0701	Predicted permease
HZI73_06060	COG0640	Transcriptional regulator
HZI73_06065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZI73_06070	COG4807	Protein conserved in bacteria
HZI73_06085	COG2207	Transcriptional regulator
HZI73_06095	COG1960	acyl-CoA dehydrogenase activity
HZI73_06100	COG2086	electron transfer activity
HZI73_06105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZI73_06115	COG2192	nodulation
HZI73_06120	COG2192	nodulation
HZI73_06125	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZI73_06155	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_06155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZI73_06155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZI73_06155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZI73_06155	COG3321	synthase
HZI73_06160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZI73_06165	COG1132	(ABC) transporter
HZI73_06170	COG1132	(ABC) transporter
HZI73_06225	COG1307	EDD domain protein, DegV family
HZI73_06245	COG2239	Acts as a magnesium transporter
HZI73_06255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZI73_06260	COG0254	rRNA binding
HZI73_06265	COG3872	metal-dependent enzyme
HZI73_06275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZI73_06280	COG0475	glutathione-regulated potassium exporter activity
HZI73_06295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZI73_06300	COG0284	orotidine-5'-phosphate decarboxylase activity
HZI73_06320	COG0543	2 iron, 2 sulfur cluster binding
HZI73_06325	COG0167	dihydroorotate dehydrogenase activity
HZI73_06330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZI73_06340	COG3290	protein histidine kinase activity
HZI73_06350	COG4864	UPF0365 protein
HZI73_06355	COG3279	Response regulator of the LytR AlgR family
HZI73_06375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZI73_06380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZI73_06385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZI73_06390	COG0189	ligase activity
HZI73_06400	COG0489	protein tyrosine kinase activity
HZI73_06455	COG0525	valine-tRNA ligase activity
HZI73_06460	COG0285	dihydrofolate synthase activity
HZI73_06490	COG2172	sigma factor antagonist activity
HZI73_06495	COG1191	sigma factor activity
HZI73_06525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZI73_06530	COG1418	mRNA catabolic process
HZI73_06550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZI73_06555	COG0436	Aminotransferase
HZI73_06570	COG5012	cobalamin binding
HZI73_06575	COG5012	cobalamin binding
HZI73_06580	COG2207	Transcriptional regulator
HZI73_06590	COG2207	Transcriptional regulator
HZI73_06590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZI73_06595	COG2201	protein-glutamate methylesterase activity
HZI73_06605	COG1653	transport
HZI73_06610	COG1175	transmembrane transport
HZI73_06615	COG0395	ABC-type sugar transport system, permease component
HZI73_06645	COG0095	Lipoate-protein ligase
HZI73_06650	COG1739	Uncharacterized protein family UPF0029
HZI73_06660	COG0745	RESPONSE REGULATOR receiver
HZI73_06665	COG3850	Histidine kinase
HZI73_06665	COG5002	protein histidine kinase activity
HZI73_06670	COG2033	superoxide reductase activity
HZI73_06705	COG2957	Belongs to the agmatine deiminase family
HZI73_06710	COG0726	polysaccharide deacetylase
HZI73_06735	COG3383	formate dehydrogenase (NAD+) activity
HZI73_06740	COG0746	molybdenum cofactor guanylyltransferase activity
HZI73_06745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZI73_06750	COG1396	sequence-specific DNA binding
HZI73_06770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HZI73_06785	COG1321	iron dependent repressor
HZI73_06790	COG4106	trans-aconitate 2-methyltransferase activity
HZI73_06795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZI73_06800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZI73_06820	COG1362	aminopeptidase activity
HZI73_06830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_06840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZI73_06860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZI73_06875	COG1116	anion transmembrane transporter activity
HZI73_06890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZI73_06905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZI73_06910	COG4496	protein, YerC YecD
HZI73_06930	COG0210	DNA helicase
HZI73_06985	COG3344	reverse transcriptase
HZI73_07025	COG1971	Probably functions as a manganese efflux pump
HZI73_07035	COG1968	undecaprenyl-diphosphatase activity
HZI73_07055	COG4978	Transcriptional regulator
HZI73_07055	COG0789	Transcriptional regulator
HZI73_07060	COG2267	carboxylic ester hydrolase activity
HZI73_07070	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_07080	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_07090	COG1653	transport
HZI73_07095	COG4209	transmembrane transport
HZI73_07100	COG0395	ABC-type sugar transport system, permease component
HZI73_07125	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_07155	COG0129	dihydroxy-acid dehydratase activity
HZI73_07170	COG1744	ABC transporter substrate-binding protein PnrA-like
HZI73_07175	COG3845	ABC transporter
HZI73_07180	COG4603	Belongs to the binding-protein-dependent transport system permease family
HZI73_07185	COG1079	Belongs to the binding-protein-dependent transport system permease family
HZI73_07195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZI73_07195	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZI73_07200	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZI73_07205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZI73_07205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZI73_07210	COG3119	arylsulfatase activity
HZI73_07215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZI73_07225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZI73_07265	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZI73_07275	COG3119	arylsulfatase activity
HZI73_07280	COG4209	transmembrane transport
HZI73_07285	COG0395	ABC-type sugar transport system, permease component
HZI73_07290	COG1653	transport
HZI73_07300	COG2207	Transcriptional regulator
HZI73_07300	COG4753	response regulator
HZI73_07310	COG3408	Glycogen debranching enzyme
HZI73_07310	COG3119	arylsulfatase activity
HZI73_07325	COG3250	beta-galactosidase activity
HZI73_07330	COG4209	transmembrane transport
HZI73_07335	COG0395	ABC-type sugar transport system, permease component
HZI73_07340	COG1653	transport
HZI73_07355	COG3119	arylsulfatase activity
HZI73_07360	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_07370	COG3279	Response regulator of the LytR AlgR family
HZI73_07385	COG3119	arylsulfatase activity
HZI73_07390	COG3408	Glycogen debranching enzyme
HZI73_07390	COG3119	arylsulfatase activity
HZI73_07395	COG3708	Transcriptional regulator
HZI73_07395	COG2207	Transcriptional regulator
HZI73_07400	COG4209	transmembrane transport
HZI73_07405	COG0395	ABC-type sugar transport system, permease component
HZI73_07410	COG3250	beta-galactosidase activity
HZI73_07430	COG0584	glycerophosphoryl diester phosphodiesterase
HZI73_07445	COG1609	Transcriptional regulator
HZI73_07450	COG1070	Carbohydrate kinase
HZI73_07455	COG0667	Aldo Keto reductase
HZI73_07460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HZI73_07465	COG2972	Histidine kinase
HZI73_07470	COG2207	Transcriptional regulator
HZI73_07470	COG4753	response regulator
HZI73_07495	COG0366	Alpha amylase catalytic
HZI73_07520	COG2255	four-way junction helicase activity
HZI73_07540	COG1846	Transcriptional regulator
HZI73_07550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZI73_07555	COG0095	Lipoate-protein ligase
HZI73_07565	COG2972	Histidine kinase
HZI73_07570	COG4753	response regulator
HZI73_07570	COG2207	Transcriptional regulator
HZI73_07595	COG1609	Transcriptional regulator
HZI73_07605	COG1175	transmembrane transport
HZI73_07610	COG0395	ABC-type sugar transport system, permease component
HZI73_07615	COG1554	hydrolase, family 65, central catalytic
HZI73_07625	COG4977	sequence-specific DNA binding
HZI73_07635	COG1312	Catalyzes the dehydration of D-mannonate
HZI73_07640	COG0006	proline dipeptidase activity
HZI73_07645	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_07650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZI73_07650	COG0473	3-isopropylmalate dehydrogenase activity
HZI73_07660	COG3708	Transcriptional regulator
HZI73_07660	COG2207	Transcriptional regulator
HZI73_07695	COG1129	ABC transporter
HZI73_07705	COG1879	ABC-type sugar transport system periplasmic component
HZI73_07710	COG0745	RESPONSE REGULATOR receiver
HZI73_07710	COG2972	Histidine kinase
HZI73_07715	COG2207	Transcriptional regulator
HZI73_07735	COG0747	negative chemotaxis
HZI73_07745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_07750	COG0444	Belongs to the ABC transporter superfamily
HZI73_07755	COG4608	Belongs to the ABC transporter superfamily
HZI73_07765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZI73_07770	COG4977	sequence-specific DNA binding
HZI73_07770	COG1917	Cupin 2, conserved barrel domain protein
HZI73_07775	COG0549	Belongs to the carbamate kinase family
HZI73_07790	COG1653	transport
HZI73_07795	COG4209	transmembrane transport
HZI73_07800	COG0395	ABC-type sugar transport system, permease component
HZI73_07815	COG1917	Cupin 2, conserved barrel domain protein
HZI73_07825	COG2972	Histidine kinase
HZI73_07830	COG4753	response regulator
HZI73_07830	COG2207	Transcriptional regulator
HZI73_07840	COG0395	ABC-type sugar transport system, permease component
HZI73_07845	COG1653	transport
HZI73_07855	COG2188	Transcriptional regulator
HZI73_07865	COG4209	transmembrane transport
HZI73_07870	COG0395	ABC-type sugar transport system, permease component
HZI73_07875	COG1653	transport
HZI73_07880	COG2207	Transcriptional regulator
HZI73_07910	COG4948	Mandelate Racemase Muconate Lactonizing
HZI73_07915	COG1012	belongs to the aldehyde dehydrogenase family
HZI73_07920	COG0800	Aldolase
HZI73_07930	COG3250	beta-galactosidase activity
HZI73_07955	COG1501	Belongs to the glycosyl hydrolase 31 family
HZI73_07970	COG3119	arylsulfatase activity
HZI73_07980	COG1653	transport
HZI73_07990	COG4209	transmembrane transport
HZI73_07995	COG0395	ABC-type sugar transport system, permease component
HZI73_08010	COG2207	Transcriptional regulator
HZI73_08020	COG3119	arylsulfatase activity
HZI73_08035	COG4209	transmembrane transport
HZI73_08040	COG0395	ABC-type sugar transport system, permease component
HZI73_08045	COG3119	arylsulfatase activity
HZI73_08050	COG5434	Belongs to the glycosyl hydrolase 28 family
HZI73_08055	COG3119	arylsulfatase activity
HZI73_08060	COG3250	beta-galactosidase activity
HZI73_08065	COG3119	arylsulfatase activity
HZI73_08070	COG3119	arylsulfatase activity
HZI73_08115	COG1082	Xylose isomerase domain protein TIM barrel
HZI73_08125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZI73_08135	COG2186	Transcriptional regulator
HZI73_08140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZI73_08145	COG2186	Transcriptional regulator
HZI73_08155	COG0149	triose-phosphate isomerase activity
HZI73_08165	COG0310	cobalt ion transport
HZI73_08175	COG1122	ATPase activity
HZI73_08180	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HZI73_08185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZI73_08190	COG1691	(AIR) carboxylase
HZI73_08205	COG1346	cytolysis
HZI73_08225	COG3973	AAA domain
HZI73_08230	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HZI73_08270	COG1175	transmembrane transport
HZI73_08275	COG0395	ABC-type sugar transport system, permease component
HZI73_08295	COG1175	transmembrane transport
HZI73_08300	COG3833	ABC-type maltose transport systems, permease component
HZI73_08305	COG3420	alginic acid biosynthetic process
HZI73_08315	COG3275	phosphorelay sensor kinase activity
HZI73_08320	COG2207	Transcriptional regulator
HZI73_08330	COG4209	transmembrane transport
HZI73_08335	COG0395	ABC-type sugar transport system, permease component
HZI73_08365	COG1609	Transcriptional regulator
HZI73_08380	COG4209	transmembrane transport
HZI73_08385	COG0395	ABC-type sugar transport system, permease component
HZI73_08390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZI73_08395	COG3876	Protein conserved in bacteria
HZI73_08400	COG2971	BadF BadG BcrA BcrD
HZI73_08415	COG3290	protein histidine kinase activity
HZI73_08415	COG0840	transmembrane signaling receptor activity
HZI73_08425	COG0071	Belongs to the small heat shock protein (HSP20) family
HZI73_08460	COG0716	FMN binding
HZI73_08470	COG3275	phosphorelay sensor kinase activity
HZI73_08475	COG4753	response regulator
HZI73_08475	COG2207	Transcriptional regulator
HZI73_08480	COG4213	ABC transporter substrate-binding protein
HZI73_08495	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_08500	COG4659	FMN binding
HZI73_08540	COG0523	cobalamin synthesis protein
HZI73_08545	COG2378	regulation of single-species biofilm formation
HZI73_08565	COG0714	Associated with various cellular activities
HZI73_08600	COG1131	(ABC) transporter
HZI73_08610	COG0789	Transcriptional regulator
HZI73_08615	COG3459	Glycosyltransferase 36 associated
HZI73_08620	COG2207	Transcriptional regulator
HZI73_08620	COG4753	response regulator
HZI73_08625	COG2972	Histidine kinase
HZI73_08640	COG4209	transmembrane transport
HZI73_08645	COG0395	ABC-type sugar transport system, permease component
HZI73_08650	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZI73_08655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZI73_08710	COG4912	Dna alkylation repair
HZI73_08720	COG0346	lactoylglutathione lyase activity
HZI73_08750	COG2602	Beta-lactamase
HZI73_08760	COG1309	transcriptional regulator
HZI73_08770	COG0463	Glycosyl transferase, family 2
HZI73_08770	COG0457	Tetratricopeptide repeat
HZI73_08775	COG0463	Glycosyl transferase, family 2
HZI73_08785	COG0463	Glycosyl transferase, family 2
HZI73_08785	COG0457	Tetratricopeptide repeat
HZI73_08805	COG3711	transcriptional antiterminator
HZI73_08810	COG1263	PTS System
HZI73_08810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZI73_08810	COG2190	(PTS) system
HZI73_08815	COG1263	PTS System
HZI73_08815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZI73_08815	COG2190	(PTS) system
HZI73_08835	COG1940	carbohydrate kinase activity
HZI73_08840	COG1070	Carbohydrate kinase
HZI73_08850	COG3773	Cell wall hydrolase
HZI73_08870	COG1704	LemA family
HZI73_08890	COG2207	Transcriptional regulator
HZI73_08890	COG3708	Transcriptional regulator
HZI73_08900	COG5002	protein histidine kinase activity
HZI73_08905	COG2720	vancomycin resistance protein
HZI73_08910	COG2814	Major facilitator Superfamily
HZI73_08915	COG2226	methyltransferase
HZI73_08920	COG2267	carboxylic ester hydrolase activity
HZI73_08935	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HZI73_08945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZI73_08955	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HZI73_08965	COG0534	Mate efflux family protein
HZI73_08985	COG0735	belongs to the Fur family
HZI73_08990	COG1132	(ABC) transporter
HZI73_08995	COG1132	(ABC) transporter
HZI73_09005	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZI73_09010	COG1121	(ABC) transporter
HZI73_09015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZI73_09020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZI73_09035	COG2972	Histidine kinase
HZI73_09040	COG4753	response regulator
HZI73_09040	COG2207	Transcriptional regulator
HZI73_09040	COG4753	response regulator
HZI73_09040	COG2207	Transcriptional regulator
HZI73_09050	COG1129	ABC transporter
HZI73_09055	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_09060	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_09085	COG2832	Protein of unknown function (DUF454)
HZI73_09110	COG1940	carbohydrate kinase activity
HZI73_09135	COG1733	regulation of RNA biosynthetic process
HZI73_09145	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZI73_09155	COG0517	IMP dehydrogenase activity
HZI73_09165	COG1129	ABC transporter
HZI73_09170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_09185	COG2197	response regulator
HZI73_09190	COG2972	Histidine kinase
HZI73_09210	COG1609	Transcriptional regulator
HZI73_09220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZI73_09230	COG2972	Histidine kinase
HZI73_09235	COG4753	response regulator
HZI73_09235	COG2207	Transcriptional regulator
HZI73_09245	COG1175	transmembrane transport
HZI73_09270	COG0673	inositol 2-dehydrogenase activity
HZI73_09280	COG0785	Cytochrome C biogenesis protein
HZI73_09285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZI73_09290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZI73_09290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZI73_09295	COG4753	response regulator
HZI73_09295	COG2207	Transcriptional regulator
HZI73_09300	COG2972	Histidine kinase
HZI73_09325	COG1609	Transcriptional regulator
HZI73_09330	COG1175	transmembrane transport
HZI73_09335	COG0395	ABC-type sugar transport system, permease component
HZI73_09340	COG0463	Glycosyl transferase, family 2
HZI73_09370	COG3119	arylsulfatase activity
HZI73_09380	COG4585	Histidine kinase
HZI73_09385	COG2197	response regulator
HZI73_09390	COG1131	(ABC) transporter
HZI73_09400	COG0842	Transport permease protein
HZI73_09410	COG1695	Transcriptional regulator
HZI73_09415	COG4619	ABC transporter
HZI73_09420	COG0390	transport system, permease component
HZI73_09425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZI73_09445	COG2135	peptidase activity
HZI73_09450	COG0584	glycerophosphoryl diester phosphodiesterase
HZI73_09455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZI73_09455	COG1796	DNA polymerase
HZI73_09480	COG0432	Pfam Uncharacterised protein family UPF0047
HZI73_09490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZI73_09495	COG1032	radical SAM domain protein
HZI73_09500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZI73_09515	COG0431	NADPH-dependent FMN reductase
HZI73_09515	COG1053	succinate dehydrogenase
HZI73_09515	COG3976	FMN-binding domain protein
HZI73_09550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZI73_09555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZI73_09630	COG0673	inositol 2-dehydrogenase activity
HZI73_09635	COG1131	(ABC) transporter
HZI73_09660	COG0574	Belongs to the PEP-utilizing enzyme family
HZI73_09660	COG3848	Pyruvate phosphate dikinase
HZI73_09670	COG0312	modulator of DNA gyrase
HZI73_09675	COG0312	modulator of DNA gyrase
HZI73_09695	COG1757	Na H antiporter
HZI73_09720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZI73_09735	COG1609	Transcriptional regulator
HZI73_09745	COG1609	Transcriptional regulator
HZI73_09750	COG1882	Formate acetyltransferase
HZI73_09755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZI73_09760	COG1070	Carbohydrate kinase
HZI73_09765	COG1129	ABC transporter
HZI73_09770	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_09775	COG1879	ABC-type sugar transport system periplasmic component
HZI73_09795	COG0191	fructose-bisphosphate aldolase activity
HZI73_09800	COG1164	Oligoendopeptidase f
HZI73_09815	COG0641	radical SAM
HZI73_09835	COG3546	catalase activity
HZI73_09840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZI73_09875	COG2207	Transcriptional regulator
HZI73_09875	COG1917	Cupin 2, conserved barrel domain protein
HZI73_09890	COG0673	inositol 2-dehydrogenase activity
HZI73_09910	COG1725	Transcriptional regulator
HZI73_09915	COG0789	Transcriptional regulator
HZI73_09935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZI73_09945	COG4865	methylaspartate mutase activity
HZI73_09950	COG3799	methylaspartate ammonia-lyase activity
HZI73_09965	COG1349	DNA-binding transcription factor activity
HZI73_09970	COG1175	transmembrane transport
HZI73_10020	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HZI73_10030	COG2340	Cysteine-rich secretory protein family
HZI73_10035	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZI73_10095	COG1802	Transcriptional regulator
HZI73_10100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_10105	COG2972	Histidine kinase
HZI73_10110	COG4753	response regulator
HZI73_10110	COG2207	Transcriptional regulator
HZI73_10115	COG4209	transmembrane transport
HZI73_10120	COG0395	ABC-type sugar transport system, permease component
HZI73_10130	COG0840	transmembrane signaling receptor activity
HZI73_10135	COG0488	(ABC) transporter
HZI73_10140	COG2996	Protein conserved in bacteria
HZI73_10175	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HZI73_10180	COG1840	ABC-type Fe3 transport system, periplasmic component
HZI73_10190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZI73_10215	COG1725	Transcriptional regulator
HZI73_10220	COG1131	(ABC) transporter
HZI73_10230	COG0813	purine-nucleoside phosphorylase activity
HZI73_10240	COG0489	protein tyrosine kinase activity
HZI73_10245	COG2894	cell division
HZI73_10255	COG0735	belongs to the Fur family
HZI73_10275	COG0840	transmembrane signaling receptor activity
HZI73_10295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZI73_10305	COG1592	Rubrerythrin
HZI73_10310	COG1414	Transcriptional regulator
HZI73_10315	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HZI73_10320	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_10330	COG1012	belongs to the aldehyde dehydrogenase family
HZI73_10355	COG0513	Belongs to the DEAD box helicase family
HZI73_10365	COG0398	Pfam SNARE associated Golgi protein
HZI73_10410	COG2323	membrane
HZI73_10415	COG0651	ATP synthesis coupled electron transport
HZI73_10420	COG1006	Multisubunit Na H antiporter MnhC subunit
HZI73_10425	COG2111	Na H antiporter
HZI73_10440	COG1320	monovalent cation:proton antiporter activity
HZI73_10445	COG2212	antiporter activity
HZI73_10475	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HZI73_10480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZI73_10490	COG1342	Belongs to the UPF0251 family
HZI73_10495	COG2200	EAL domain
HZI73_10515	COG1045	serine acetyltransferase
HZI73_10520	COG0215	cysteine-tRNA ligase activity
HZI73_10530	COG2244	polysaccharide biosynthetic process
HZI73_10535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZI73_10550	COG3688	RNA-binding protein containing a PIN domain
HZI73_10580	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZI73_10600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HZI73_10605	COG0459	protein refolding
HZI73_10615	COG0516	GMP reductase activity
HZI73_10615	COG0517	IMP dehydrogenase activity
HZI73_10620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZI73_10625	COG0573	inorganic phosphate transmembrane transporter activity
HZI73_10635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZI73_10640	COG0704	Plays a role in the regulation of phosphate uptake
HZI73_10645	COG0745	RESPONSE REGULATOR receiver
HZI73_10650	COG5002	protein histidine kinase activity
HZI73_10655	COG1554	hydrolase, family 65, central catalytic
HZI73_10660	COG1609	Transcriptional regulator
HZI73_10680	COG0519	Catalyzes the synthesis of GMP from XMP
HZI73_10780	COG1917	Cupin 2, conserved barrel domain protein
HZI73_10780	COG2207	Transcriptional regulator
HZI73_10790	COG0450	alkyl hydroperoxide reductase
HZI73_10795	COG3634	alkyl hydroperoxide reductase activity
HZI73_10800	COG3119	arylsulfatase activity
HZI73_10815	COG2972	Histidine kinase
HZI73_10820	COG2207	Transcriptional regulator
HZI73_10820	COG4753	response regulator
HZI73_10845	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_10850	COG4209	transmembrane transport
HZI73_10855	COG0395	ABC-type sugar transport system, permease component
HZI73_10885	COG3708	Transcriptional regulator
HZI73_10885	COG2207	Transcriptional regulator
HZI73_10905	COG4209	transmembrane transport
HZI73_10910	COG0395	ABC-type sugar transport system, permease component
HZI73_10920	COG2252	PERMEase
HZI73_10940	COG1882	Formate acetyltransferase
HZI73_10945	COG0138	bifunctional purine biosynthesis protein purh
HZI73_10950	COG0534	Mate efflux family protein
HZI73_10975	COG4555	ABC transporter
HZI73_10980	COG1956	GAF domain-containing protein
HZI73_10985	COG2972	Histidine kinase
HZI73_10990	COG2207	Transcriptional regulator
HZI73_10990	COG4753	response regulator
HZI73_10995	COG1653	transport
HZI73_11000	COG1175	transmembrane transport
HZI73_11005	COG0395	ABC-type sugar transport system, permease component
HZI73_11015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZI73_11020	COG1609	Transcriptional regulator
HZI73_11025	COG1904	glucuronate isomerase
HZI73_11030	COG0800	Aldolase
HZI73_11055	COG1132	(ABC) transporter
HZI73_11085	COG1122	ATPase activity
HZI73_11090	COG1122	ATPase activity
HZI73_11115	COG0840	transmembrane signaling receptor activity
HZI73_11120	COG0840	transmembrane signaling receptor activity
HZI73_11135	COG5002	protein histidine kinase activity
HZI73_11135	COG0642	Histidine kinase
HZI73_11150	COG1175	transmembrane transport
HZI73_11155	COG0395	ABC-type sugar transport system, permease component
HZI73_11160	COG1136	(ABC) transporter
HZI73_11170	COG0577	efflux transmembrane transporter activity
HZI73_11170	COG1136	(ABC) transporter
HZI73_11175	COG1381	Involved in DNA repair and RecF pathway recombination
HZI73_11180	COG0423	glycine-tRNA ligase activity
HZI73_11185	COG0574	Belongs to the PEP-utilizing enzyme family
HZI73_11185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZI73_11190	COG4399	Belongs to the UPF0754 family
HZI73_11205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZI73_11210	COG0358	DNA primase activity
HZI73_11215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZI73_11220	COG2384	SAM-dependent methyltransferase
HZI73_11225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZI73_11230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZI73_11240	COG5002	protein histidine kinase activity
HZI73_11245	COG0745	RESPONSE REGULATOR receiver
HZI73_11295	COG0673	inositol 2-dehydrogenase activity
HZI73_11300	COG0366	Alpha amylase catalytic
HZI73_11320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZI73_11325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZI73_11330	COG0826	peptidase U32
HZI73_11340	COG3773	Cell wall hydrolase
HZI73_11340	COG3409	Peptidoglycan-binding domain 1 protein
HZI73_11360	COG0542	response to heat
HZI73_11365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZI73_11375	COG0205	6-phosphofructokinase activity
HZI73_11395	COG0287	Prephenate dehydrogenase
HZI73_11400	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZI73_11420	COG0495	leucyl-tRNA aminoacylation
HZI73_11445	COG1404	Belongs to the peptidase S8 family
HZI73_11460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZI73_11465	COG0473	3-isopropylmalate dehydrogenase activity
HZI73_11470	COG1802	Transcriptional regulator
HZI73_11475	COG0321	lipoyl(octanoyl) transferase activity
HZI73_11480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZI73_11485	COG2222	sugar isomerase
HZI73_11495	COG2188	Transcriptional regulator
HZI73_11500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_11505	COG1653	transport
HZI73_11510	COG1175	transmembrane transport
HZI73_11515	COG0395	ABC-type sugar transport system, permease component
HZI73_11520	COG2222	sugar isomerase
HZI73_11525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZI73_11530	COG0534	Mate efflux family protein
HZI73_11535	COG0488	(ABC) transporter
HZI73_11545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HZI73_11550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZI73_11555	COG0583	DNA-binding transcription factor activity
HZI73_11580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZI73_11580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZI73_11590	COG2337	Toxic component of a toxin-antitoxin (TA) module
HZI73_11600	COG0534	Mate efflux family protein
HZI73_11615	COG1136	(ABC) transporter
HZI73_11645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZI73_11650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZI73_11655	COG0154	amidase activity
HZI73_11660	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZI73_11670	COG2746	aminoglycoside 3-N-acetyltransferase activity
HZI73_11685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HZI73_11690	COG0372	Belongs to the citrate synthase family
HZI73_11700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZI73_11710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZI73_11710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZI73_11725	COG1561	YicC-like family, N-terminal region
HZI73_11735	COG0194	GDP metabolic process
HZI73_11740	COG1758	RNA polymerase activity
HZI73_11745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZI73_11750	COG0242	peptide deformylase activity
HZI73_11755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZI73_11760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZI73_11760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZI73_11765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZI73_11775	COG2815	serine threonine protein kinase
HZI73_11775	COG0515	serine threonine protein kinase
HZI73_11780	COG1162	GTPase activity
HZI73_11785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZI73_11800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZI73_11805	COG1302	Protein conserved in bacteria
HZI73_11810	COG1461	Dihydroxyacetone kinase
HZI73_11815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZI73_11825	COG0742	ribosomal rna small subunit methyltransferase
HZI73_11830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZI73_11840	COG3314	Sporulation integral membrane protein YlbJ
HZI73_11845	COG1323	Belongs to the UPF0348 family
HZI73_11850	COG0280	phosphate acetyltransferase
HZI73_11855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZI73_11860	COG1131	(ABC) transporter
HZI73_11875	COG4585	Histidine kinase
HZI73_11880	COG2197	response regulator
HZI73_11890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZI73_11895	COG0416	fatty acid biosynthetic process
HZI73_11900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZI73_11915	COG0552	protein localization to endoplasmic reticulum
HZI73_11920	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HZI73_11925	COG0347	Belongs to the P(II) protein family
HZI73_11930	COG0004	ammonium transporteR
HZI73_11940	COG1132	(ABC) transporter
HZI73_11945	COG1132	(ABC) transporter
HZI73_11960	COG1653	transport
HZI73_11970	COG0395	ABC-type sugar transport system, permease component
HZI73_11975	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HZI73_11990	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HZI73_11995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZI73_12000	COG0228	four-way junction DNA binding
HZI73_12010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZI73_12015	COG0336	Belongs to the RNA methyltransferase TrmD family
HZI73_12020	COG0335	large ribosomal subunit rRNA binding
HZI73_12030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HZI73_12040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZI73_12050	COG2257	FlhB HrpN YscU SpaS Family
HZI73_12055	COG0792	nuclease activity
HZI73_12065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZI73_12095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZI73_12100	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HZI73_12105	COG0779	Required for maturation of 30S ribosomal subunits
HZI73_12110	COG0195	Participates in both transcription termination and antitermination
HZI73_12115	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HZI73_12120	COG1358	cellular component organization or biogenesis
HZI73_12125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZI73_12130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZI73_12135	COG2404	hydrolase activity, acting on ester bonds
HZI73_12140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZI73_12145	COG0196	riboflavin kinase activity
HZI73_12150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZI73_12155	COG1185	polyribonucleotide nucleotidyltransferase activity
HZI73_12160	COG0612	Peptidase, M16
HZI73_12170	COG0667	Aldo Keto reductase
HZI73_12185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HZI73_12260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZI73_12290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZI73_12310	COG2304	oxidoreductase activity
HZI73_12315	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_12320	COG1737	Transcriptional regulator
HZI73_12325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZI73_12330	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_12335	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZI73_12340	COG4948	Mandelate Racemase Muconate Lactonizing
HZI73_12355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZI73_12360	COG0527	aspartate kinase activity
HZI73_12365	COG0740	serine-type endopeptidase activity
HZI73_12375	COG0789	Transcriptional regulator
HZI73_12380	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_12385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZI73_12400	COG1968	undecaprenyl-diphosphatase activity
HZI73_12405	COG1674	ftsk spoiiie
HZI73_12410	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HZI73_12415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZI73_12420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZI73_12425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZI73_12430	COG1058	Belongs to the CinA family
HZI73_12430	COG1546	Belongs to the CinA family
HZI73_12445	COG2137	regulation of response to DNA damage stimulus
HZI73_12450	COG1418	mRNA catabolic process
HZI73_12455	COG2359	stage V sporulation protein S
HZI73_12465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZI73_12470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZI73_12485	COG4974	Belongs to the 'phage' integrase family
HZI73_12500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZI73_12510	COG3858	chitin binding
HZI73_12520	COG2207	Transcriptional regulator
HZI73_12535	COG2323	membrane
HZI73_12545	COG0456	acetyltransferase
HZI73_12555	COG0697	spore germination
HZI73_12600	COG1592	Rubrerythrin
HZI73_12600	COG1773	rubredoxin
HZI73_12605	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZI73_12615	COG1686	Belongs to the peptidase S11 family
HZI73_12620	COG0667	Aldo Keto reductase
HZI73_12630	COG3426	butyrate kinase activity
HZI73_12635	COG0280	phosphate acetyltransferase
HZI73_12640	COG1132	(ABC) transporter
HZI73_12650	COG0641	radical SAM
HZI73_12665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZI73_12670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZI73_12675	COG1686	Belongs to the peptidase S11 family
HZI73_12680	COG1187	pseudouridine synthase activity
HZI73_12690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZI73_12700	COG4770	biotin carboxylase activity
HZI73_12705	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HZI73_12715	COG1737	Transcriptional regulator
HZI73_12720	COG2081	HI0933 family
HZI73_12725	COG4401	Chorismate mutase type I
HZI73_12730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZI73_12735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZI73_12740	COG0539	negative regulation of cytoplasmic translation
HZI73_12740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZI73_12745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZI73_12760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZI73_12765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZI73_12775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZI73_12780	COG1923	regulation of RNA biosynthetic process
HZI73_12785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HZI73_12790	COG0714	Associated with various cellular activities
HZI73_12820	COG1131	(ABC) transporter
HZI73_12845	COG0456	acetyltransferase
HZI73_12855	COG1609	Transcriptional regulator
HZI73_12860	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZI73_12870	COG3842	ATPase activity
HZI73_12875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZI73_12880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZI73_12885	COG0402	S-adenosylhomocysteine deaminase activity
HZI73_12890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZI73_12895	COG0509	glycine decarboxylation via glycine cleavage system
HZI73_12900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZI73_12905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZI73_12910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZI73_12915	COG1522	sequence-specific DNA binding
HZI73_12920	COG0686	Belongs to the AlaDH PNT family
HZI73_12955	COG0793	Belongs to the peptidase S41A family
HZI73_12975	COG1193	negative regulation of DNA recombination
HZI73_12980	COG2315	Protein conserved in bacteria
HZI73_12995	COG0668	transmembrane transport
HZI73_13000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZI73_13005	COG0551	DNA topoisomerase type I activity
HZI73_13005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZI73_13025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZI73_13025	COG0539	negative regulation of cytoplasmic translation
HZI73_13030	COG1609	Transcriptional regulator
HZI73_13035	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZI73_13100	COG0393	Putative heavy-metal-binding
HZI73_13120	COG5002	protein histidine kinase activity
HZI73_13130	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HZI73_13150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZI73_13160	COG0402	S-adenosylhomocysteine deaminase activity
HZI73_13170	COG4753	response regulator
HZI73_13170	COG2207	Transcriptional regulator
HZI73_13175	COG2972	Histidine kinase
HZI73_13245	COG0012	GTP binding
HZI73_13265	COG2001	Belongs to the MraZ family
HZI73_13270	COG0275	rRNA processing
HZI73_13280	COG0768	penicillin binding
HZI73_13285	COG0768	penicillin binding
HZI73_13290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZI73_13295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZI73_13300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZI73_13310	COG0772	Belongs to the SEDS family
HZI73_13315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZI73_13325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZI73_13335	COG1191	sigma factor activity
HZI73_13340	COG1191	sigma factor activity
HZI73_13350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZI73_13355	COG0606	chelatase, subunit chli
HZI73_13365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZI73_13370	COG2348	transferase activity, transferring amino-acyl groups
HZI73_13375	COG0758	DNA mediated transformation
HZI73_13380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZI73_13390	COG1815	bacterial-type flagellum-dependent cell motility
HZI73_13400	COG1677	Flagellar hook-basal body complex protein FliE
HZI73_13405	COG1766	The M ring may be actively involved in energy transduction
HZI73_13410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZI73_13435	COG3144	bacterial-type flagellum assembly
HZI73_13440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZI73_13465	COG1360	Flagellar Motor Protein
HZI73_13475	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZI73_13480	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZI73_13480	COG1776	CheC inhibitor of MCP methylation
HZI73_13485	COG2201	protein-glutamate methylesterase activity
HZI73_13495	COG1338	Plays a role in the flagellum-specific transport system
HZI73_13500	COG1987	bacterial-type flagellum assembly
HZI73_13505	COG1684	flagellar biosynthetic protein fliR
HZI73_13510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZI73_13515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZI73_13520	COG1419	protein localization to endoplasmic reticulum
HZI73_13535	COG2201	protein-glutamate methylesterase activity
HZI73_13540	COG2198	Histidine kinase
HZI73_13540	COG0643	Histidine kinase
HZI73_13550	COG1776	CheC inhibitor of MCP methylation
HZI73_13555	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HZI73_13565	COG1191	sigma factor activity
HZI73_13590	COG0052	Belongs to the universal ribosomal protein uS2 family
HZI73_13595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZI73_13600	COG0528	UMP kinase activity
HZI73_13605	COG0233	cytoplasmic translational termination
HZI73_13615	COG0575	Belongs to the CDS family
HZI73_13625	COG0750	zinc metalloprotease
HZI73_13630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZI73_13640	COG0733	neurotransmitter:sodium symporter activity
HZI73_13650	COG0328	RNA-DNA hybrid ribonuclease activity
HZI73_13655	COG0142	geranyltranstransferase activity
HZI73_13665	COG2357	RelA SpoT domain protein
HZI73_13675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZI73_13675	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HZI73_13680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZI73_13700	COG1686	Belongs to the peptidase S11 family
HZI73_13710	COG4221	oxidoreductase activity
HZI73_13715	COG1525	nuclease
HZI73_13725	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_13730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZI73_13735	COG0662	Cupin 2, conserved barrel domain protein
HZI73_13735	COG2207	Transcriptional regulator
HZI73_13760	COG0351	phosphomethylpyrimidine kinase
HZI73_13760	COG0352	thiamine-phosphate diphosphorylase activity
HZI73_13765	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HZI73_13770	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZI73_13790	COG0564	pseudouridine synthase activity
HZI73_13795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZI73_13800	COG3331	DNA recombination
HZI73_13830	COG0124	histidyl-tRNA synthetase
HZI73_13835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZI73_13840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZI73_13845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZI73_13850	COG0131	Imidazoleglycerol-phosphate dehydratase
HZI73_13855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZI73_13860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZI73_13895	COG1027	Aspartate ammonia-lyase
HZI73_13905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZI73_13910	COG0745	RESPONSE REGULATOR receiver
HZI73_13915	COG2205	protein histidine kinase activity
HZI73_13920	COG1131	(ABC) transporter
HZI73_13960	COG4656	Part of a membrane complex involved in electron transport
HZI73_13965	COG4658	electron transport chain
HZI73_13975	COG4660	Part of a membrane complex involved in electron transport
HZI73_13980	COG4657	Part of a membrane complex involved in electron transport
HZI73_13985	COG1245	4Fe-4S binding domain
HZI73_13985	COG2878	Part of a membrane complex involved in electron transport
HZI73_13995	COG0424	maF-like protein
HZI73_14000	COG2003	Belongs to the UPF0758 family
HZI73_14005	COG1077	Cell shape determining protein MreB Mrl
HZI73_14020	COG0768	penicillin binding
HZI73_14030	COG2894	cell division
HZI73_14035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZI73_14040	COG0772	Belongs to the SEDS family
HZI73_14045	COG1803	Methylglyoxal synthase
HZI73_14055	COG2155	Conserved Protein
HZI73_14095	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HZI73_14125	COG1966	Carbon starvation protein
HZI73_14135	COG3275	phosphorelay sensor kinase activity
HZI73_14150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZI73_14160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZI73_14165	COG1799	cell septum assembly
HZI73_14170	COG0762	integral membrane protein
HZI73_14175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZI73_14180	COG3599	regulation of cell shape
HZI73_14185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZI73_14195	COG0564	pseudouridine synthase activity
HZI73_14200	COG0246	Mannitol dehydrogenase
HZI73_14205	COG2721	sulfolactate sulfo-lyase activity
HZI73_14210	COG0673	inositol 2-dehydrogenase activity
HZI73_14215	COG2207	Transcriptional regulator
HZI73_14220	COG4106	trans-aconitate 2-methyltransferase activity
HZI73_14230	COG4974	Belongs to the 'phage' integrase family
HZI73_14260	COG0534	Mate efflux family protein
HZI73_14275	COG1051	belongs to the nudix hydrolase family
HZI73_14290	COG0187	DNA topoisomerase II activity
HZI73_14295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZI73_14300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZI73_14305	COG1309	transcriptional regulator
HZI73_14310	COG1012	belongs to the aldehyde dehydrogenase family
HZI73_14320	COG2226	methyltransferase
HZI73_14335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZI73_14340	COG2022	thiamine diphosphate biosynthetic process
HZI73_14350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZI73_14355	COG2233	PERMEase
HZI73_14365	COG3119	arylsulfatase activity
HZI73_14370	COG3119	arylsulfatase activity
HZI73_14375	COG3858	chitin binding
HZI73_14380	COG0540	Belongs to the ATCase OTCase family
HZI73_14385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZI73_14395	COG2217	Heavy metal translocating P-type atpase
HZI73_14400	COG2207	Transcriptional regulator
HZI73_14430	COG0640	Transcriptional regulator
HZI73_14445	COG2911	Protein conserved in bacteria
HZI73_14445	COG3266	domain, Protein
HZI73_14445	COG1361	Conserved repeat domain
HZI73_14450	COG1695	Transcriptional regulator
HZI73_14455	COG0596	Alpha beta hydrolase
HZI73_14480	COG0693	protein deglycase activity
HZI73_14485	COG2378	regulation of single-species biofilm formation
HZI73_14500	COG1388	LysM domain
HZI73_14500	COG3858	chitin binding
HZI73_14505	COG0037	tRNA processing
HZI73_14510	COG4974	Belongs to the 'phage' integrase family
HZI73_14520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZI73_14525	COG0799	negative regulation of ribosome biogenesis
HZI73_14530	COG1713	HD superfamily hydrolase involved in NAD metabolism
HZI73_14550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZI73_14555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZI73_14565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZI73_14570	COG1530	ribonuclease E activity
HZI73_14590	COG0367	asparagine synthase
HZI73_14595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZI73_14605	COG1773	rubredoxin
HZI73_14615	COG0730	response to heat
HZI73_14620	COG0246	Mannitol dehydrogenase
HZI73_14625	COG1312	Catalyzes the dehydration of D-mannonate
HZI73_14635	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZI73_14640	COG2848	UPF0210 protein
HZI73_14650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZI73_14670	COG0237	dephospho-CoA kinase activity
HZI73_14675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZI73_14675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZI73_14685	COG1595	DNA-templated transcription, initiation
HZI73_14710	COG1309	transcriptional regulator
HZI73_14775	COG2273	Hydrolase Family 16
HZI73_14775	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZI73_14780	COG0402	S-adenosylhomocysteine deaminase activity
HZI73_14790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZI73_14795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZI73_14805	COG2080	2 iron, 2 sulfur cluster binding
HZI73_14810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZI73_14815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZI73_14820	COG0549	Belongs to the carbamate kinase family
HZI73_14825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZI73_14830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZI73_14840	COG0402	S-adenosylhomocysteine deaminase activity
HZI73_14845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZI73_14845	COG0493	'glutamate synthase
HZI73_14865	COG1129	ABC transporter
HZI73_14870	COG2201	protein-glutamate methylesterase activity
HZI73_14875	COG2972	Histidine kinase
HZI73_14895	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZI73_14895	COG3608	succinylglutamate desuccinylase aspartoacylase
HZI73_14900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZI73_14905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZI73_14930	COG1051	belongs to the nudix hydrolase family
HZI73_14935	COG0768	penicillin binding
HZI73_14945	COG0826	peptidase U32
HZI73_14960	COG2255	four-way junction helicase activity
HZI73_14965	COG0632	four-way junction helicase activity
HZI73_14990	COG0723	plastoquinol--plastocyanin reductase activity
HZI73_15000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZI73_15010	COG0561	phosphatase activity
HZI73_15015	COG3711	transcriptional antiterminator
HZI73_15020	COG1263	PTS System
HZI73_15020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZI73_15020	COG2190	(PTS) system
HZI73_15045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZI73_15050	COG4224	UPF0291 protein
HZI73_15060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZI73_15065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HZI73_15070	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZI73_15075	COG2081	HI0933 family
HZI73_15080	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_15090	COG0728	peptidoglycan biosynthetic process
HZI73_15095	COG0295	cytidine deaminase activity
HZI73_15100	COG1470	cell adhesion involved in biofilm formation
HZI73_15105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZI73_15110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZI73_15120	COG1702	phosphate starvation-inducible protein PhoH
HZI73_15135	COG1610	YqeY-like protein
HZI73_15140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZI73_15150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZI73_15165	COG0395	ABC-type sugar transport system, permease component
HZI73_15180	COG1609	Transcriptional regulator
HZI73_15185	COG1388	LysM domain
HZI73_15185	COG3942	CHAP domain
HZI73_15195	COG0697	spore germination
HZI73_15200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZI73_15210	COG2323	membrane
HZI73_15215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZI73_15220	COG0488	(ABC) transporter
HZI73_15235	COG0285	dihydrofolate synthase activity
HZI73_15240	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZI73_15280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZI73_15290	COG1136	(ABC) transporter
HZI73_15295	COG0577	efflux transmembrane transporter activity
HZI73_15305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZI73_15330	COG1944	ATP diphosphatase activity
HZI73_15345	COG0840	transmembrane signaling receptor activity
HZI73_15360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZI73_15365	COG2205	protein histidine kinase activity
HZI73_15375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_15380	COG1486	melibiose metabolic process
HZI73_15385	COG0395	ABC-type sugar transport system, permease component
HZI73_15395	COG1653	transport
HZI73_15415	COG0745	RESPONSE REGULATOR receiver
HZI73_15420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZI73_15425	COG3287	FIST C domain
HZI73_15425	COG2199	diguanylate cyclase activity
HZI73_15425	COG2200	EAL domain
HZI73_15435	COG3285	dna ligase
HZI73_15435	COG1793	dna ligase
HZI73_15440	COG1793	dna ligase
HZI73_15445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HZI73_15465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZI73_15485	COG1361	Conserved repeat domain
HZI73_15485	COG2911	Protein conserved in bacteria
HZI73_15485	COG3266	domain, Protein
HZI73_15505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZI73_15510	COG1011	Hydrolase
HZI73_15515	COG0706	membrane insertase activity
HZI73_15520	COG0384	phenazine biosynthesis protein PhzF
HZI73_15540	COG3340	Belongs to the peptidase S51 family
HZI73_15565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HZI73_15665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZI73_15670	COG0427	acetyl-CoA hydrolase
HZI73_15675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZI73_15720	COG0183	Belongs to the thiolase family
HZI73_15725	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_15745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZI73_15760	COG0824	Thioesterase
HZI73_15770	COG1609	Transcriptional regulator
HZI73_15780	COG1917	Cupin 2, conserved barrel domain protein
HZI73_15780	COG2169	Transcriptional regulator
HZI73_15795	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_15810	COG0395	ABC-type sugar transport system, permease component
HZI73_15815	COG4209	transmembrane transport
HZI73_15820	COG2972	Histidine kinase
HZI73_15825	COG4753	response regulator
HZI73_15825	COG2207	Transcriptional regulator
HZI73_15840	COG1917	Cupin 2, conserved barrel domain protein
HZI73_15840	COG4977	sequence-specific DNA binding
HZI73_15855	COG4977	sequence-specific DNA binding
HZI73_15855	COG1917	Cupin 2, conserved barrel domain protein
HZI73_15860	COG1501	Belongs to the glycosyl hydrolase 31 family
HZI73_15865	COG0395	ABC-type sugar transport system, permease component
HZI73_15870	COG1175	transmembrane transport
HZI73_15890	COG0698	ribose 5-phosphate isomerase
HZI73_15895	COG3958	Transketolase
HZI73_15900	COG3959	Transketolase, thiamine diphosphate binding domain
HZI73_15905	COG0471	metal ion transport
HZI73_15910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZI73_15915	COG0045	succinate-CoA ligase (ADP-forming) activity
HZI73_15920	COG1012	belongs to the aldehyde dehydrogenase family
HZI73_15935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZI73_15940	COG0124	histidyl-tRNA synthetase
HZI73_15945	COG0159	tryptophan synthase activity
HZI73_15950	COG0133	tryptophan synthase activity
HZI73_15955	COG0135	phosphoribosylanthranilate isomerase activity
HZI73_15960	COG0134	indole-3-glycerol-phosphate synthase activity
HZI73_15965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZI73_15970	COG0512	Glutamine amidotransferase of anthranilate synthase
HZI73_15970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZI73_15980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZI73_15985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZI73_15990	COG1490	D-aminoacyl-tRNA deacylase activity
HZI73_15995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZI73_16015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZI73_16025	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZI73_16035	COG0535	radical SAM domain protein
HZI73_16040	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HZI73_16060	COG0347	Belongs to the P(II) protein family
HZI73_16070	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HZI73_16080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZI73_16085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZI73_16085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZI73_16090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZI73_16090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZI73_16095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZI73_16110	COG0613	PHP domain protein
HZI73_16125	COG1862	Preprotein translocase
HZI73_16130	COG0343	queuine tRNA-ribosyltransferase activity
HZI73_16135	COG5001	Diguanylate cyclase
HZI73_16135	COG3300	MHYT domain
HZI73_16145	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZI73_16150	COG1121	(ABC) transporter
HZI73_16155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZI73_16160	COG1725	Transcriptional regulator
HZI73_16200	COG2244	polysaccharide biosynthetic process
HZI73_16220	COG0395	ABC-type sugar transport system, permease component
HZI73_16225	COG1175	transmembrane transport
HZI73_16235	COG1609	Transcriptional regulator
HZI73_16240	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HZI73_16250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZI73_16280	COG0154	amidase activity
HZI73_16325	COG3119	arylsulfatase activity
HZI73_16330	COG1082	Xylose isomerase domain protein TIM barrel
HZI73_16335	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_16350	COG3250	beta-galactosidase activity
HZI73_16360	COG0395	ABC-type sugar transport system, permease component
HZI73_16365	COG4209	transmembrane transport
HZI73_16375	COG3275	phosphorelay sensor kinase activity
HZI73_16380	COG2207	Transcriptional regulator
HZI73_16380	COG4753	response regulator
HZI73_16430	COG1082	Xylose isomerase domain protein TIM barrel
HZI73_16435	COG0673	inositol 2-dehydrogenase activity
HZI73_16440	COG0644	oxidoreductase
HZI73_16445	COG0406	alpha-ribazole phosphatase activity
HZI73_16450	COG3706	GGDEF domain
HZI73_16455	COG1550	Protein conserved in bacteria
HZI73_16480	COG1929	Belongs to the glycerate kinase type-1 family
HZI73_16490	COG3835	regulator
HZI73_16505	COG0750	zinc metalloprotease
HZI73_16510	COG0497	DNA recombination
HZI73_16515	COG1438	arginine binding
HZI73_16520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZI73_16525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HZI73_16530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZI73_16555	COG1570	exodeoxyribonuclease VII activity
HZI73_16560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZI73_16565	COG1302	Protein conserved in bacteria
HZI73_16605	COG3854	ATPases associated with a variety of cellular activities
HZI73_16615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZI73_16620	COG0006	proline dipeptidase activity
HZI73_16625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZI73_16635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZI73_16640	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HZI73_16650	COG1335	isochorismatase
HZI73_16755	COG1131	(ABC) transporter
HZI73_16770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZI73_16780	COG1011	Hydrolase
HZI73_16800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZI73_16805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZI73_16815	COG0107	imidazoleglycerol-phosphate synthase activity
HZI73_16850	COG0826	peptidase U32
HZI73_16855	COG4122	O-methyltransferase activity
HZI73_16860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZI73_16870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZI73_16875	COG0735	belongs to the Fur family
HZI73_16885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZI73_16890	COG4472	Bacterial protein of unknown function (DUF965)
HZI73_16895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZI73_16915	COG0301	tRNA thio-modification
HZI73_16925	COG2201	protein-glutamate methylesterase activity
HZI73_16930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZI73_16935	COG2264	protein methyltransferase activity
HZI73_16940	COG0484	heat shock protein binding
HZI73_16945	COG0443	Heat shock 70 kDa protein
HZI73_16950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZI73_16955	COG1420	regulation of RNA biosynthetic process
HZI73_16960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZI73_16965	COG0481	GTPase activity
HZI73_16975	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZI73_16980	COG0268	Binds directly to 16S ribosomal RNA
HZI73_16995	COG1073	alpha beta
HZI73_17000	COG0658	competence protein
HZI73_17000	COG2333	competence protein COMEC
HZI73_17010	COG5002	protein histidine kinase activity
HZI73_17015	COG0745	RESPONSE REGULATOR receiver
HZI73_17020	COG1555	photosystem II stabilization
HZI73_17030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZI73_17030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZI73_17040	COG2200	EAL domain
HZI73_17045	COG0789	Transcriptional regulator
HZI73_17055	COG1305	Transglutaminase-like
HZI73_17065	COG0714	Associated with various cellular activities
HZI73_17095	COG0442	prolyl-tRNA aminoacylation
HZI73_17110	COG0737	Belongs to the 5'-nucleotidase family
HZI73_17125	COG0701	Predicted permease
HZI73_17130	COG1132	(ABC) transporter
HZI73_17135	COG2375	cellular response to nickel ion
HZI73_17135	COG1132	(ABC) transporter
HZI73_17140	COG2226	methyltransferase
HZI73_17150	COG0735	belongs to the Fur family
HZI73_17160	COG4716	Myosin-crossreactive antigen
HZI73_17165	COG1573	uracil-dna glycosylase
HZI73_17170	COG1132	(ABC) transporter
HZI73_17175	COG1132	(ABC) transporter
HZI73_17185	COG2207	Transcriptional regulator
HZI73_17195	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZI73_17195	COG0493	'glutamate synthase
HZI73_17205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZI73_17210	COG0505	Belongs to the CarA family
HZI73_17215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZI73_17220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZI73_17225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZI73_17230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZI73_17235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZI73_17240	COG0137	argininosuccinate synthase activity
HZI73_17245	COG0165	Argininosuccinate lyase
HZI73_17265	COG1595	DNA-templated transcription, initiation
HZI73_17275	COG1309	transcriptional regulator
HZI73_17280	COG0534	Mate efflux family protein
HZI73_17290	COG1361	Conserved repeat domain
HZI73_17295	COG2190	(PTS) system
HZI73_17300	COG1263	PTS System
HZI73_17300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZI73_17300	COG2190	(PTS) system
HZI73_17325	COG0312	modulator of DNA gyrase
HZI73_17345	COG4536	flavin adenine dinucleotide binding
HZI73_17355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZI73_17365	COG0330	HflC and HflK could
HZI73_17380	COG0028	Belongs to the TPP enzyme family
HZI73_17385	COG0129	dihydroxy-acid dehydratase activity
HZI73_17390	COG0473	3-isopropylmalate dehydrogenase activity
HZI73_17395	COG0066	3-isopropylmalate dehydratase activity
HZI73_17400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZI73_17405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZI73_17410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZI73_17440	COG0348	domain, Protein
HZI73_17440	COG3901	Regulator of nitric oxide reductase transcription
HZI73_17450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZI73_17465	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZI73_17470	COG1518	maintenance of DNA repeat elements
HZI73_17505	COG2378	regulation of single-species biofilm formation
HZI73_17545	COG1126	abc transporter atp-binding protein
HZI73_17550	COG0765	amino acid transport
HZI73_17555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZI73_17570	COG0646	methionine synthase
HZI73_17570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZI73_17600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZI73_17600	COG0551	DNA topoisomerase type I activity
HZI73_17605	COG1307	EDD domain protein, DegV family
HZI73_17610	COG0530	calcium, potassium:sodium antiporter activity
HZI73_17630	COG0789	Transcriptional regulator
HZI73_17650	COG3457	Alanine racemase
HZI73_17660	COG5012	cobalamin binding
HZI73_17670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZI73_17680	COG3804	dihydrodipicolinate reductase
HZI73_17685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZI73_17690	COG2235	arginine
HZI73_17720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZI73_17725	COG0673	inositol 2-dehydrogenase activity
HZI73_17735	COG3962	Belongs to the TPP enzyme family
HZI73_17750	COG1012	belongs to the aldehyde dehydrogenase family
HZI73_17755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_17765	COG0673	inositol 2-dehydrogenase activity
HZI73_17770	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_17775	COG1129	ABC transporter
HZI73_17780	COG1879	ABC-type sugar transport system periplasmic component
HZI73_17790	COG2972	Histidine kinase
HZI73_17805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_17815	COG3250	beta-galactosidase activity
HZI73_17820	COG0737	Belongs to the 5'-nucleotidase family
HZI73_17835	COG2207	Transcriptional regulator
HZI73_17835	COG3708	Transcriptional regulator
HZI73_17840	COG0778	Nitroreductase
HZI73_17845	COG0277	FAD linked oxidase domain protein
HZI73_17870	COG1131	(ABC) transporter
HZI73_17875	COG0395	ABC-type sugar transport system, permease component
HZI73_17880	COG4209	transmembrane transport
HZI73_17885	COG1653	transport
HZI73_17890	COG1609	Transcriptional regulator
HZI73_17890	COG2207	Transcriptional regulator
HZI73_17905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZI73_17910	COG1473	amidohydrolase
HZI73_17925	COG3404	Formiminotransferase-cyclodeaminase
HZI73_17940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZI73_17945	COG2986	histidine ammonia-lyase
HZI73_17960	COG2207	Transcriptional regulator
HZI73_17960	COG3708	Transcriptional regulator
HZI73_17970	COG0596	Alpha beta hydrolase
HZI73_17975	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZI73_17980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HZI73_17985	COG1193	negative regulation of DNA recombination
HZI73_17995	COG1509	lysine 2,3-aminomutase activity
HZI73_18000	COG0604	alcohol dehydrogenase
HZI73_18015	COG3246	L-lysine catabolic process to acetate
HZI73_18020	COG1607	acyl-coa hydrolase
HZI73_18025	COG0386	Belongs to the glutathione peroxidase family
HZI73_18030	COG0653	protein targeting
HZI73_18035	COG2188	Transcriptional regulator
HZI73_18050	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZI73_18055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZI73_18060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZI73_18090	COG1595	DNA-templated transcription, initiation
HZI73_18105	COG2132	Multicopper oxidase
HZI73_18120	COG3848	Pyruvate phosphate dikinase
HZI73_18120	COG0574	Belongs to the PEP-utilizing enzyme family
HZI73_18135	COG5566	PFAM Mor transcription activator
HZI73_18165	COG1733	regulation of RNA biosynthetic process
HZI73_18175	COG0793	Belongs to the peptidase S41A family
HZI73_18205	COG0662	Cupin 2, conserved barrel domain protein
HZI73_18225	COG3620	sequence-specific DNA binding
HZI73_18245	COG0596	Alpha beta hydrolase
HZI73_18270	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZI73_18280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZI73_18295	COG0557	exoribonuclease II activity
HZI73_18315	COG0148	phosphopyruvate hydratase activity
HZI73_18320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZI73_18325	COG0149	triose-phosphate isomerase activity
HZI73_18340	COG2390	Transcriptional regulator
HZI73_18350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZI73_18360	COG0482	sulfurtransferase activity
HZI73_18365	COG0822	iron-sulfur transferase activity
HZI73_18375	COG1959	2 iron, 2 sulfur cluster binding
HZI73_18385	COG0542	response to heat
HZI73_18395	COG2247	cell wall binding repeat
HZI73_18395	COG2385	sporulation resulting in formation of a cellular spore
HZI73_18400	COG1126	abc transporter atp-binding protein
HZI73_18405	COG0765	amino acid transport
HZI73_18410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZI73_18420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZI73_18435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZI73_18440	COG2205	protein histidine kinase activity
HZI73_18445	COG0745	RESPONSE REGULATOR receiver
HZI73_18450	COG1509	lysine 2,3-aminomutase activity
HZI73_18470	COG0488	(ABC) transporter
HZI73_18495	COG0577	efflux transmembrane transporter activity
HZI73_18500	COG1136	(ABC) transporter
HZI73_18505	COG0028	Belongs to the TPP enzyme family
HZI73_18510	COG2207	Transcriptional regulator
HZI73_18530	COG0395	ABC-type sugar transport system, permease component
HZI73_18535	COG4209	transmembrane transport
HZI73_18550	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_18555	COG2207	Transcriptional regulator
HZI73_18555	COG1917	Cupin 2, conserved barrel domain protein
HZI73_18565	COG1959	2 iron, 2 sulfur cluster binding
HZI73_18575	COG1295	ribonuclease BN
HZI73_18600	COG0067	glutamate synthase
HZI73_18600	COG0070	glutamate synthase
HZI73_18600	COG0069	glutamate synthase activity
HZI73_18610	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZI73_18615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZI73_18645	COG2610	gluconate transmembrane transporter activity
HZI73_18650	COG1929	Belongs to the glycerate kinase type-1 family
HZI73_18655	COG3835	regulator
HZI73_18660	COG1151	hydroxylamine reductase activity
HZI73_18680	COG0596	Alpha beta hydrolase
HZI73_18690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZI73_18705	COG3119	arylsulfatase activity
HZI73_18715	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_18730	COG0395	ABC-type sugar transport system, permease component
HZI73_18735	COG4209	transmembrane transport
HZI73_18740	COG2972	Histidine kinase
HZI73_18745	COG2207	Transcriptional regulator
HZI73_18745	COG4753	response regulator
HZI73_18760	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_18795	COG3328	transposase activity
HZI73_18800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZI73_18810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZI73_18820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZI73_18835	COG2207	Transcriptional regulator
HZI73_18840	COG3250	beta-galactosidase activity
HZI73_18850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZI73_18855	COG4106	trans-aconitate 2-methyltransferase activity
HZI73_18870	COG0572	uridine kinase
HZI73_18890	COG0024	Methionine aminopeptidase
HZI73_18895	COG0513	Belongs to the DEAD box helicase family
HZI73_18910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZI73_18915	COG0438	transferase activity, transferring glycosyl groups
HZI73_18920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZI73_18925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZI73_18940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HZI73_18955	COG1979	alcohol dehydrogenase
HZI73_18960	COG0789	Transcriptional regulator
HZI73_18995	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_19000	COG3833	ABC-type maltose transport systems, permease component
HZI73_19005	COG1175	transmembrane transport
HZI73_19010	COG2182	Extracellular solute-binding protein
HZI73_19020	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HZI73_19025	COG2942	2-epimerase
HZI73_19045	COG4716	Myosin-crossreactive antigen
HZI73_19065	COG1131	(ABC) transporter
HZI73_19075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZI73_19100	COG0714	Associated with various cellular activities
HZI73_19105	COG1653	transport
HZI73_19115	COG1131	(ABC) transporter
HZI73_19145	COG0395	ABC-type sugar transport system, permease component
HZI73_19150	COG4209	transmembrane transport
HZI73_19160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZI73_19170	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZI73_19175	COG2086	electron transfer activity
HZI73_19180	COG1960	acyl-CoA dehydrogenase activity
HZI73_19185	COG2030	dehydratase
HZI73_19220	COG4636	protein conserved in cyanobacteria
HZI73_19225	COG4166	transmembrane transport
HZI73_19230	COG4608	Belongs to the ABC transporter superfamily
HZI73_19235	COG0444	Belongs to the ABC transporter superfamily
HZI73_19240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_19245	COG0601	transmembrane transport
HZI73_19260	COG1960	acyl-CoA dehydrogenase activity
HZI73_19265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZI73_19270	COG2086	electron transfer activity
HZI73_19295	COG0410	ABC transporter
HZI73_19305	COG0604	alcohol dehydrogenase
HZI73_19310	COG1846	Transcriptional regulator
HZI73_19315	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZI73_19320	COG0628	permease
HZI73_19340	COG1854	S-ribosylhomocysteine lyase activity
HZI73_19370	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZI73_19375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZI73_19380	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HZI73_19385	COG5002	protein histidine kinase activity
HZI73_19385	COG3850	Histidine kinase
HZI73_19390	COG0745	RESPONSE REGULATOR receiver
HZI73_19415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZI73_19415	COG2207	Transcriptional regulator
HZI73_19420	COG2972	Histidine kinase
HZI73_19430	COG0745	RESPONSE REGULATOR receiver
HZI73_19440	COG4608	Belongs to the ABC transporter superfamily
HZI73_19445	COG0444	Belongs to the ABC transporter superfamily
HZI73_19450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_19455	COG0601	transmembrane transport
HZI73_19475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZI73_19480	COG0583	DNA-binding transcription factor activity
HZI73_19485	COG2226	methyltransferase
HZI73_19490	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_19525	COG3842	ATPase activity
HZI73_19530	COG3833	ABC-type maltose transport systems, permease component
HZI73_19535	COG1175	transmembrane transport
HZI73_19555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HZI73_19575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZI73_19585	COG0542	response to heat
HZI73_19590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HZI73_19595	COG3880	PFAM UvrB UvrC protein
HZI73_19605	COG0785	Cytochrome C biogenesis protein
HZI73_19615	COG3859	Proton-coupled thiamine transporter YuaJ
HZI73_19640	COG0484	heat shock protein binding
HZI73_19705	COG1307	EDD domain protein, DegV family
HZI73_19730	COG0151	Belongs to the GarS family
HZI73_19735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZI73_19740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZI73_19745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HZI73_19755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZI73_19760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZI73_19810	COG0133	tryptophan synthase activity
HZI73_19815	COG0670	Belongs to the BI1 family
HZI73_19825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZI73_19845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZI73_19850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZI73_19855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZI73_19865	COG0697	spore germination
HZI73_19880	COG1307	EDD domain protein, DegV family
HZI73_19920	COG1388	LysM domain
HZI73_19920	COG3858	chitin binding
HZI73_19925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZI73_19930	COG1054	Belongs to the UPF0176 family
HZI73_19935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZI73_19940	COG4585	Histidine kinase
HZI73_19945	COG2197	response regulator
HZI73_19950	COG1131	(ABC) transporter
HZI73_19970	COG1725	Transcriptional regulator
HZI73_19975	COG1131	(ABC) transporter
HZI73_19990	COG1136	(ABC) transporter
HZI73_20000	COG0577	efflux transmembrane transporter activity
HZI73_20020	COG0697	spore germination
HZI73_20035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZI73_20040	COG1940	carbohydrate kinase activity
HZI73_20060	COG3250	beta-galactosidase activity
HZI73_20065	COG2972	Histidine kinase
HZI73_20070	COG2207	Transcriptional regulator
HZI73_20070	COG4753	response regulator
HZI73_20090	COG0395	ABC-type sugar transport system, permease component
HZI73_20095	COG1175	transmembrane transport
HZI73_20100	COG4753	response regulator
HZI73_20100	COG2207	Transcriptional regulator
HZI73_20105	COG2972	Histidine kinase
HZI73_20130	COG0395	ABC-type sugar transport system, permease component
HZI73_20135	COG4209	transmembrane transport
HZI73_20140	COG2207	Transcriptional regulator
HZI73_20170	COG1349	DNA-binding transcription factor activity
HZI73_20175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZI73_20175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZI73_20175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZI73_20190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZI73_20195	COG1957	nucleoside hydrolase
HZI73_20210	COG0475	glutathione-regulated potassium exporter activity
HZI73_20235	COG0457	Tetratricopeptide repeat
HZI73_20240	COG1879	ABC-type sugar transport system periplasmic component
HZI73_20245	COG3279	Response regulator of the LytR AlgR family
HZI73_20250	COG2972	Histidine kinase
HZI73_20255	COG0457	Tetratricopeptide repeat
HZI73_20275	COG1129	ABC transporter
HZI73_20285	COG2207	Transcriptional regulator
HZI73_20285	COG3708	Transcriptional regulator
HZI73_20310	COG3409	Peptidoglycan-binding domain 1 protein
HZI73_20310	COG3773	Cell wall hydrolase
HZI73_20325	COG3409	Peptidoglycan-binding domain 1 protein
HZI73_20325	COG3773	Cell wall hydrolase
HZI73_20335	COG2197	response regulator
HZI73_20340	COG4585	Histidine kinase
HZI73_20345	COG1131	(ABC) transporter
HZI73_20360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZI73_20395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_20400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_20410	COG3958	Transketolase
HZI73_20415	COG3959	Transketolase, thiamine diphosphate binding domain
HZI73_20420	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_20425	COG1609	Transcriptional regulator
HZI73_20440	COG0746	molybdenum cofactor guanylyltransferase activity
HZI73_20460	COG0437	4 iron, 4 sulfur cluster binding
HZI73_20465	COG0243	molybdopterin cofactor binding
HZI73_20470	COG2390	Transcriptional regulator
HZI73_20480	COG1309	transcriptional regulator
HZI73_20505	COG0395	ABC-type sugar transport system, permease component
HZI73_20525	COG1132	(ABC) transporter
HZI73_20535	COG4978	Transcriptional regulator
HZI73_20535	COG0789	Transcriptional regulator
HZI73_20545	COG2378	regulation of single-species biofilm formation
HZI73_20555	COG0534	Mate efflux family protein
HZI73_20605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZI73_20620	COG1874	Beta-galactosidase
HZI73_20635	COG2376	Dihydroxyacetone kinase
HZI73_20640	COG1461	Dihydroxyacetone kinase
HZI73_20645	COG1082	Xylose isomerase domain protein TIM barrel
HZI73_20665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZI73_20670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZI73_20675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZI73_20685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZI73_20690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HZI73_20725	COG1309	transcriptional regulator
HZI73_20750	COG2119	membrane
HZI73_20755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZI73_20760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZI73_20765	COG0426	domain, Protein
HZI73_20770	COG0697	spore germination
HZI73_20795	COG1609	Transcriptional regulator
HZI73_20800	COG1070	Carbohydrate kinase
HZI73_20805	COG1376	ErfK ybiS ycfS ynhG family protein
HZI73_20820	COG2211	Major facilitator Superfamily
HZI73_20825	COG3394	polysaccharide catabolic process
HZI73_20845	COG1285	pathogenesis
HZI73_20850	COG2770	Histidine kinase
HZI73_20850	COG2205	protein histidine kinase activity
HZI73_20855	COG0745	RESPONSE REGULATOR receiver
HZI73_20860	COG1917	Cupin 2, conserved barrel domain protein
HZI73_20860	COG2207	Transcriptional regulator
HZI73_20870	COG1132	(ABC) transporter
HZI73_20885	COG1683	Conserved Protein
HZI73_20890	COG0395	ABC-type sugar transport system, permease component
HZI73_20895	COG1175	transmembrane transport
HZI73_20905	COG3279	Response regulator of the LytR AlgR family
HZI73_20910	COG3275	phosphorelay sensor kinase activity
HZI73_20915	COG0514	ATP-dependent DNA helicase (RecQ)
HZI73_20950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HZI73_20965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HZI73_20970	COG0823	Involved in the tonB-independent uptake of proteins
HZI73_20980	COG4608	Belongs to the ABC transporter superfamily
HZI73_20985	COG0444	Belongs to the ABC transporter superfamily
HZI73_20990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_20995	COG0601	transmembrane transport
HZI73_21000	COG0747	negative chemotaxis
HZI73_21015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HZI73_21035	COG1609	Transcriptional regulator
HZI73_21050	COG0395	ABC-type sugar transport system, permease component
HZI73_21055	COG4209	transmembrane transport
HZI73_21075	COG1328	CTP reductase activity
HZI73_21075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZI73_21080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZI73_21105	COG1120	ATPase activity
HZI73_21110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZI73_21120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZI73_21160	COG1132	(ABC) transporter
HZI73_21165	COG1971	Probably functions as a manganese efflux pump
HZI73_21175	COG0277	FAD linked oxidase domain protein
HZI73_21180	COG1070	Carbohydrate kinase
HZI73_21205	COG0534	Mate efflux family protein
HZI73_21210	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_21215	COG1917	Cupin 2, conserved barrel domain protein
HZI73_21235	COG3842	ATPase activity
HZI73_21255	COG0395	ABC-type sugar transport system, permease component
HZI73_21260	COG4209	transmembrane transport
HZI73_21280	COG0697	spore germination
HZI73_21300	COG3119	arylsulfatase activity
HZI73_21315	COG3250	beta-galactosidase activity
HZI73_21325	COG1653	transport
HZI73_21330	COG0395	ABC-type sugar transport system, permease component
HZI73_21335	COG4209	transmembrane transport
HZI73_21345	COG3250	beta-galactosidase activity
HZI73_21375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZI73_21385	COG1876	peptidase activity
HZI73_21390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZI73_21400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZI73_21410	COG1609	Transcriptional regulator
HZI73_21415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZI73_21420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZI73_21440	COG3119	arylsulfatase activity
HZI73_21460	COG3459	Glycosyltransferase 36 associated
HZI73_21470	COG0395	ABC-type sugar transport system, permease component
HZI73_21475	COG4209	transmembrane transport
HZI73_21480	COG2201	protein-glutamate methylesterase activity
HZI73_21485	COG2972	Histidine kinase
HZI73_21500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZI73_21505	COG2226	methyltransferase
HZI73_21525	COG0673	inositol 2-dehydrogenase activity
HZI73_21545	COG1074	ATP-dependent DNA helicase activity
HZI73_21555	COG0383	alpha-mannosidase activity
HZI73_21565	COG3842	ATPase activity
HZI73_21575	COG1175	transmembrane transport
HZI73_21590	COG1472	Belongs to the glycosyl hydrolase 3 family
HZI73_21595	COG2207	Transcriptional regulator
HZI73_21605	COG0523	cobalamin synthesis protein
HZI73_21635	COG1309	transcriptional regulator
HZI73_21640	COG0596	Alpha beta hydrolase
HZI73_21645	COG1394	ATPase activity, coupled to movement of substances
HZI73_21675	COG1269	ATP hydrolysis coupled proton transport
HZI73_21695	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HZI73_21750	COG1597	lipid kinase activity
HZI73_21765	COG4641	Protein conserved in bacteria
HZI73_21765	COG1388	LysM domain
HZI73_21775	COG0438	transferase activity, transferring glycosyl groups
HZI73_21780	COG0457	Tetratricopeptide repeat
HZI73_21780	COG0463	Glycosyl transferase, family 2
HZI73_21785	COG1653	transport
HZI73_21790	COG0395	ABC-type sugar transport system, permease component
HZI73_21795	COG4209	transmembrane transport
HZI73_21800	COG2207	Transcriptional regulator
HZI73_21810	COG2972	Histidine kinase
HZI73_21820	COG0395	ABC-type sugar transport system, permease component
HZI73_21825	COG4209	transmembrane transport
HZI73_21830	COG1653	transport
HZI73_21850	COG1216	Glycosyl transferase, family 2
HZI73_21870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZI73_21890	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZI73_21895	COG1091	dTDP-4-dehydrorhamnose reductase activity
HZI73_21905	COG1331	Highly conserved protein containing a thioredoxin domain
HZI73_21920	COG4608	Belongs to the ABC transporter superfamily
HZI73_21925	COG0444	Belongs to the ABC transporter superfamily
HZI73_21930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_21935	COG0601	transmembrane transport
HZI73_21940	COG4166	transmembrane transport
HZI73_21950	COG2207	Transcriptional regulator
HZI73_21950	COG4753	response regulator
HZI73_21955	COG2911	Protein conserved in bacteria
HZI73_21955	COG1361	Conserved repeat domain
HZI73_21955	COG3266	domain, Protein
HZI73_21965	COG0395	ABC-type sugar transport system, permease component
HZI73_21970	COG1175	transmembrane transport
HZI73_21975	COG2207	Transcriptional regulator
HZI73_21975	COG4753	response regulator
HZI73_21980	COG2972	Histidine kinase
HZI73_21990	COG4608	Belongs to the ABC transporter superfamily
HZI73_21995	COG0444	Belongs to the ABC transporter superfamily
HZI73_22000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_22040	COG2207	Transcriptional regulator
HZI73_22040	COG0662	Cupin 2, conserved barrel domain protein
HZI73_22055	COG1131	(ABC) transporter
HZI73_22080	COG1012	belongs to the aldehyde dehydrogenase family
HZI73_22085	COG4948	Mandelate Racemase Muconate Lactonizing
HZI73_22095	COG1802	Transcriptional regulator
HZI73_22100	COG1082	Xylose isomerase domain protein TIM barrel
HZI73_22125	COG1129	ABC transporter
HZI73_22130	COG1609	Transcriptional regulator
HZI73_22140	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HZI73_22165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZI73_22170	COG1063	alcohol dehydrogenase
HZI73_22180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZI73_22195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZI73_22260	COG4974	Belongs to the 'phage' integrase family
HZI73_22385	COG0740	serine-type endopeptidase activity
HZI73_22465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZI73_22530	COG4974	Belongs to the 'phage' integrase family
HZI73_22615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZI73_22620	COG1528	Iron-storage protein
HZI73_22635	COG1234	tRNA 3'-trailer cleavage
HZI73_22645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZI73_22650	COG1067	ATP-dependent peptidase activity
HZI73_22665	COG0456	acetyltransferase
HZI73_22670	COG1214	PFAM Peptidase M22, glycoprotease
HZI73_22675	COG0802	atpase or kinase
HZI73_22685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HZI73_22700	COG1950	PFAM Membrane protein of
HZI73_22725	COG2183	response to ionizing radiation
HZI73_22730	COG0395	ABC-type sugar transport system, permease component
HZI73_22735	COG1175	transmembrane transport
HZI73_22745	COG4753	response regulator
HZI73_22745	COG2207	Transcriptional regulator
HZI73_22750	COG2972	Histidine kinase
HZI73_22760	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HZI73_22765	COG0460	homoserine dehydrogenase
HZI73_22770	COG4492	Belongs to the UPF0735 family
HZI73_22775	COG0835	chemotaxis
HZI73_22785	COG0653	protein targeting
HZI73_22810	COG1070	Carbohydrate kinase
HZI73_22815	COG4154	Belongs to the RbsD FucU family
HZI73_22820	COG1105	Belongs to the carbohydrate kinase PfkB family
HZI73_22830	COG1063	alcohol dehydrogenase
HZI73_22835	COG0656	L-ascorbic acid biosynthetic process
HZI73_22850	COG4989	oxidoreductase activity
HZI73_22855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZI73_22860	COG2210	Belongs to the sulfur carrier protein TusA family
HZI73_22900	COG0556	nucleotide-excision repair
HZI73_22905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZI73_22910	COG3409	Peptidoglycan-binding domain 1 protein
HZI73_22910	COG0793	Belongs to the peptidase S41A family
HZI73_22915	COG1196	nuclear chromosome segregation
HZI73_22915	COG0741	lytic transglycosylase activity
HZI73_22915	COG0739	heme binding
HZI73_22920	COG2177	Part of the ABC transporter FtsEX involved in
HZI73_22925	COG2884	Cell division ATP-binding protein ftsE
HZI73_22930	COG3835	regulator
HZI73_22935	COG3842	ATPase activity
HZI73_22940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZI73_22975	COG0297	glycogen (starch) synthase activity
HZI73_22995	COG0110	maltose O-acetyltransferase activity
HZI73_23015	COG1316	TRANSCRIPTIONal
HZI73_23020	COG1316	TRANSCRIPTIONal
HZI73_23030	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_23045	COG0489	protein tyrosine kinase activity
HZI73_23050	COG3944	biosynthesis protein
HZI73_23055	COG4464	protein tyrosine phosphatase activity
HZI73_23095	COG0728	peptidoglycan biosynthetic process
HZI73_23100	COG0438	transferase activity, transferring glycosyl groups
HZI73_23115	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HZI73_23125	COG2089	acid synthase
HZI73_23140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZI73_23145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZI73_23155	COG0463	Glycosyl transferase, family 2
HZI73_23155	COG1216	Glycosyl transferase, family 2
HZI73_23160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZI73_23180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZI73_23185	COG1481	regulation of sporulation
HZI73_23200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZI73_23210	COG2190	(PTS) system
HZI73_23210	COG2211	Major facilitator Superfamily
HZI73_23250	COG2814	Major facilitator Superfamily
HZI73_23255	COG2313	pseudouridylate synthase activity
HZI73_23260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_23275	COG1940	carbohydrate kinase activity
HZI73_23285	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HZI73_23290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZI73_23295	COG1473	amidohydrolase
HZI73_23300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZI73_23305	COG0402	S-adenosylhomocysteine deaminase activity
HZI73_23315	COG1957	nucleoside hydrolase
HZI73_23320	COG1079	Belongs to the binding-protein-dependent transport system permease family
HZI73_23325	COG4603	Belongs to the binding-protein-dependent transport system permease family
HZI73_23330	COG3845	ABC transporter
HZI73_23335	COG1744	ABC transporter substrate-binding protein PnrA-like
HZI73_23365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZI73_23375	COG0156	8-amino-7-oxononanoate synthase activity
HZI73_23380	COG0006	proline dipeptidase activity
HZI73_23410	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZI73_23415	COG0322	excinuclease ABC activity
HZI73_23420	COG1132	(ABC) transporter
HZI73_23425	COG1132	(ABC) transporter
HZI73_23435	COG0668	transmembrane transport
HZI73_23440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZI73_23485	COG1486	melibiose metabolic process
HZI73_23505	COG0210	DNA helicase
HZI73_23510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HZI73_23565	COG3279	Response regulator of the LytR AlgR family
HZI73_23660	COG0739	heme binding
HZI73_23695	COG3290	protein histidine kinase activity
HZI73_23710	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_23725	COG0488	(ABC) transporter
HZI73_23740	COG0588	phosphoglycerate mutase activity
HZI73_23745	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HZI73_23750	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HZI73_23755	COG1073	alpha beta
HZI73_23775	COG1522	sequence-specific DNA binding
HZI73_23780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZI73_23785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZI73_23785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZI73_23790	COG0307	riboflavin synthase, alpha
HZI73_23800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZI73_23805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZI73_23820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZI73_23825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZI73_23840	COG1917	Cupin 2, conserved barrel domain protein
HZI73_23840	COG4977	sequence-specific DNA binding
HZI73_23845	COG2217	Heavy metal translocating P-type atpase
HZI73_23850	COG0640	Transcriptional regulator
HZI73_23855	COG5002	protein histidine kinase activity
HZI73_23860	COG0745	RESPONSE REGULATOR receiver
HZI73_23875	COG2223	nitrite transmembrane transporter activity
HZI73_23900	COG0651	ATP synthesis coupled electron transport
HZI73_23925	COG1309	transcriptional regulator
HZI73_23955	COG1609	Transcriptional regulator
HZI73_23975	COG2897	thiosulfate sulfurtransferase activity
HZI73_23985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_23995	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZI73_24005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZI73_24020	COG2391	methyltransferase activity
HZI73_24035	COG2391	methyltransferase activity
HZI73_24055	COG0708	Exodeoxyribonuclease III
HZI73_24085	COG0673	inositol 2-dehydrogenase activity
HZI73_24100	COG0842	Transport permease protein
HZI73_24100	COG1511	domain protein
HZI73_24105	COG1131	(ABC) transporter
HZI73_24115	COG2197	response regulator
HZI73_24120	COG4585	Histidine kinase
HZI73_24130	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HZI73_24135	COG3119	arylsulfatase activity
HZI73_24140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZI73_24140	COG2207	Transcriptional regulator
HZI73_24145	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HZI73_24185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZI73_24200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZI73_24255	COG1309	transcriptional regulator
HZI73_24265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZI73_24275	COG3507	Belongs to the glycosyl hydrolase 43 family
HZI73_24280	COG3386	PFAM SMP-30 Gluconolaconase
HZI73_24285	COG1942	4-Oxalocrotonate Tautomerase
HZI73_24300	COG1733	regulation of RNA biosynthetic process
HZI73_24310	COG4608	Belongs to the ABC transporter superfamily
HZI73_24315	COG0444	Belongs to the ABC transporter superfamily
HZI73_24325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_24330	COG0601	transmembrane transport
HZI73_24355	COG0800	Aldolase
HZI73_24365	COG0395	ABC-type sugar transport system, permease component
HZI73_24370	COG1175	transmembrane transport
HZI73_24385	COG4753	response regulator
HZI73_24385	COG2207	Transcriptional regulator
HZI73_24390	COG2972	Histidine kinase
HZI73_24405	COG3119	arylsulfatase activity
HZI73_24410	COG0395	ABC-type sugar transport system, permease component
HZI73_24415	COG4209	transmembrane transport
HZI73_24430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZI73_24435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZI73_24445	COG3885	ferrous iron binding
HZI73_24445	COG2078	PFAM AMMECR1 domain protein
HZI73_24455	COG0300	oxidoreductase activity
HZI73_24490	COG4753	response regulator
HZI73_24490	COG2207	Transcriptional regulator
HZI73_24495	COG2972	Histidine kinase
HZI73_24505	COG0395	ABC-type sugar transport system, permease component
HZI73_24510	COG1175	transmembrane transport
HZI73_24525	COG3708	Transcriptional regulator
HZI73_24525	COG2207	Transcriptional regulator
HZI73_24540	COG0745	RESPONSE REGULATOR receiver
HZI73_24540	COG3292	Two component regulator propeller
HZI73_24540	COG2205	protein histidine kinase activity
HZI73_24550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZI73_24560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZI73_24580	COG1070	Carbohydrate kinase
HZI73_24585	COG0235	Class ii aldolase
HZI73_24590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZI73_24595	COG0022	dehydrogenase e1 component
HZI73_24600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZI73_24605	COG3119	arylsulfatase activity
HZI73_24620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_24625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZI73_24645	COG1653	transport
HZI73_24650	COG0395	ABC-type sugar transport system, permease component
HZI73_24655	COG4209	transmembrane transport
HZI73_24685	COG1917	Cupin 2, conserved barrel domain protein
HZI73_24685	COG2207	Transcriptional regulator
HZI73_24740	COG0534	Mate efflux family protein
HZI73_24765	COG4608	Belongs to the ABC transporter superfamily
HZI73_24775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZI73_24780	COG0601	transmembrane transport
HZI73_24790	COG0191	fructose-bisphosphate aldolase activity
HZI73_24800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZI73_24810	COG3119	arylsulfatase activity
HZI73_24835	COG0747	negative chemotaxis
HZI73_24845	COG1819	glycosyl
HZI73_24880	COG3119	arylsulfatase activity
HZI73_24890	COG0395	ABC-type sugar transport system, permease component
HZI73_24895	COG4209	transmembrane transport
HZI73_24900	COG1653	transport
HZI73_24910	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HZI73_24915	COG4120	Belongs to the binding-protein-dependent transport system permease family
HZI73_24945	COG3842	ATPase activity
HZI73_24950	COG3833	ABC-type maltose transport systems, permease component
HZI73_24985	COG1690	Belongs to the RtcB family
HZI73_25010	COG0395	ABC-type sugar transport system, permease component
HZI73_25015	COG4209	transmembrane transport
HZI73_25020	COG3275	phosphorelay sensor kinase activity
HZI73_25025	COG2207	Transcriptional regulator
HZI73_25045	COG0789	Transcriptional regulator
HZI73_25060	COG1129	ABC transporter
HZI73_25065	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_25100	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_25110	COG1653	transport
HZI73_25115	COG0395	ABC-type sugar transport system, permease component
HZI73_25120	COG4209	transmembrane transport
HZI73_25130	COG0667	Aldo Keto reductase
HZI73_25140	COG3459	Glycosyltransferase 36 associated
HZI73_25145	COG0395	ABC-type sugar transport system, permease component
HZI73_25150	COG1175	transmembrane transport
HZI73_25155	COG1653	transport
HZI73_25165	COG3275	phosphorelay sensor kinase activity
HZI73_25180	COG1501	Belongs to the glycosyl hydrolase 31 family
HZI73_25185	COG3275	phosphorelay sensor kinase activity
HZI73_25190	COG3279	Response regulator of the LytR AlgR family
HZI73_25200	COG0395	ABC-type sugar transport system, permease component
HZI73_25205	COG4209	transmembrane transport
HZI73_25220	COG0210	DNA helicase
HZI73_25255	COG2207	Transcriptional regulator
HZI73_25255	COG3708	Transcriptional regulator
HZI73_25270	COG2378	regulation of single-species biofilm formation
HZI73_25275	COG2267	carboxylic ester hydrolase activity
HZI73_25295	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_25300	COG0534	Mate efflux family protein
HZI73_25305	COG3119	arylsulfatase activity
HZI73_25310	COG4209	transmembrane transport
HZI73_25315	COG0395	ABC-type sugar transport system, permease component
HZI73_25375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZI73_25380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZI73_25385	COG3481	metal-dependent phosphohydrolase, HD sub domain
HZI73_25405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZI73_25415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZI73_25420	COG1028	Short-chain dehydrogenase reductase Sdr
HZI73_25425	COG1063	alcohol dehydrogenase
HZI73_25435	COG2972	Histidine kinase
HZI73_25450	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_25455	COG1879	ABC-type sugar transport system periplasmic component
HZI73_25460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZI73_25465	COG1129	ABC transporter
HZI73_25475	COG1024	Enoyl-CoA hydratase
HZI73_25485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZI73_25495	COG3250	beta-galactosidase activity
HZI73_25500	COG3250	beta-galactosidase activity
HZI73_25520	COG0395	ABC-type sugar transport system, permease component
HZI73_25525	COG4209	transmembrane transport
HZI73_25535	COG2207	Transcriptional regulator
HZI73_25540	COG0739	heme binding
HZI73_25560	COG1193	negative regulation of DNA recombination
HZI73_25565	COG0745	RESPONSE REGULATOR receiver
HZI73_25570	COG5002	protein histidine kinase activity
HZI73_25575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZI73_25590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZI73_25625	COG0735	belongs to the Fur family
HZI73_25630	COG0436	Aminotransferase
HZI73_25635	COG1522	sequence-specific DNA binding
HZI73_25645	COG2720	vancomycin resistance protein
HZI73_25655	COG2373	Large extracellular alpha-helical protein
HZI73_25660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZI73_25665	COG0077	Prephenate dehydratase
HZI73_25665	COG1605	Chorismate mutase
HZI73_25690	COG0572	uridine kinase
HZI73_25705	COG0395	ABC-type sugar transport system, permease component
HZI73_25710	COG1175	transmembrane transport
HZI73_25715	COG1653	transport
HZI73_25720	COG2207	Transcriptional regulator
HZI73_25720	COG4753	response regulator
HZI73_25725	COG2972	Histidine kinase
HZI73_25730	COG2207	Transcriptional regulator
HZI73_25740	COG0494	nUDIX hydrolase
HZI73_25745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZI73_25760	COG1376	ErfK ybiS ycfS ynhG family protein
HZI73_25820	COG1136	(ABC) transporter
HZI73_25825	COG0577	efflux transmembrane transporter activity
HZI73_25835	COG1785	Belongs to the alkaline phosphatase family
HZI73_25845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZI73_25850	COG0789	Transcriptional regulator
HZI73_25880	COG3778	Protein conserved in bacteria
HZI73_25885	COG3299	homolog of phage Mu protein gp47
HZI73_25905	COG1652	LysM domain
HZI73_25985	COG1131	(ABC) transporter
HZI73_26010	COG2197	response regulator
HZI73_26015	COG2207	Transcriptional regulator
HZI73_26130	COG0629	single-stranded DNA binding
HZI73_26140	COG2003	Belongs to the UPF0758 family
HZI73_26180	COG3451	type IV secretory pathway VirB4
HZI73_26190	COG0739	heme binding
HZI73_26205	COG4962	Type ii secretion system protein e
HZI73_26265	COG1361	Conserved repeat domain
HZI73_26280	COG1361	Conserved repeat domain
HZI73_26290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII