locus-tag	class	description
BU251_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
BU251_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
BU251_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
BU251_00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
BU251_00040	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
BU251_00050	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
BU251_00165	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
BU251_00185	ENOG4105E2V	Glycosyltransferase 36
BU251_00195	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
BU251_00200	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
BU251_00245	ENOG4107KJX	Transcriptional regulator
BU251_00275	ENOG4108JU6	CBS domain protein
BU251_00290	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BU251_00310	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
BU251_00320	ENOG4108J9M	Transporter
BU251_00340	ENOG4108Z0Z	intracellular protease Pfpi family
BU251_00355	ENOG4107QI6	Cysteine desulfurase
BU251_00360	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
BU251_00370	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
BU251_00375	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
BU251_00395	ENOG4107QQG	Dehydrogenase
BU251_00405	ENOG4107BJW	polysaccharide deacetylase
BU251_00420	ENOG4107R8N	Glycosyl transferase, family 2
BU251_00425	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
BU251_00430	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
BU251_00455	ENOG4105CJ1	ABC, transporter
BU251_00480	ENOG4105VZ9	UPF0235 protein
BU251_00485	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
BU251_00500	ENOG4108JU3	Alkyl hydroperoxide reductase
BU251_00505	ENOG4105VF7	tolerance protein
BU251_00510	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
BU251_00520	ENOG4105G5W	regulator Fur family
BU251_00535	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
BU251_00540	ENOG4105DDK	oxidoreductase, beta subunit
BU251_00545	ENOG4105VCQ	rubredoxin
BU251_00555	ENOG4105CNW	domain protein
BU251_00565	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
BU251_00580	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
BU251_00590	ENOG4108HHA	Transketolase
BU251_00600	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
BU251_00605	ENOG4105K4W	Could be involved in septation (By similarity)
BU251_00620	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
BU251_00625	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
BU251_00630	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
BU251_00635	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
BU251_00640	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
BU251_00645	ENOG4108SP1	single-stranded DNA-binding protein
BU251_00650	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
BU251_00655	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
BU251_00660	ENOG4105CDU	Replicative dna helicase
BU251_00665	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BU251_00675	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
BU251_00680	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
BU251_00685	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
BU251_00700	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BU251_00720	ENOG4105BZU	Histidine kinase
BU251_00740	ENOG4105D0S	secretion protein (HlyD
BU251_00750	ENOG4105CJ1	ABC, transporter
BU251_00755	ENOG4107QWP	ABC-2 type transporter
BU251_00760	ENOG4107QWP	ABC-2 type transporter
BU251_00790	ENOG4105CKK	Glycosyl transferase, family 2
BU251_00800	ENOG4105M0C	cytoplasmic protein
BU251_00810	ENOG4108UVJ	appr-1-p processing domain protein
BU251_00815	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
BU251_00820	ENOG4105D9R	oxidoreductase
BU251_00825	ENOG4105BZ1	(ABC) transporter
BU251_00830	ENOG4105CE9	30S ribosomal protein S2
BU251_00835	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
BU251_00840	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
BU251_00845	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
BU251_00865	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
BU251_00870	ENOG4105CHW	UPF0052 protein
BU251_00875	ENOG4105KRI	phosphocarrier protein (HPr
BU251_00880	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
BU251_00885	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
BU251_00890	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
BU251_00895	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
BU251_00905	ENOG4105CTQ	phosphohexokinase
BU251_00915	ENOG4105C01	Dihydroxy-acid dehydratase
BU251_00920	ENOG4105C7K	acetolactate synthase
BU251_00925	ENOG4108ZP8	Acetolactate synthase small subunit
BU251_00935	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
BU251_00940	ENOG4105E2X	shikimate dehydrogenase
BU251_00945	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
BU251_00950	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
BU251_00955	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
BU251_00960	ENOG4105C79	DNA protecting protein DprA
BU251_00965	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
BU251_00980	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
BU251_00985	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
BU251_01000	ENOG4105CPK	Glycosyl transferase (Group 1
BU251_01005	ENOG4107QPH	glycogen) synthase
BU251_01010	ENOG4107BJW	polysaccharide deacetylase
BU251_01020	ENOG4105DKP	glycosyl transferase, family 9
BU251_01045	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
BU251_01050	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
BU251_01055	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
BU251_01060	ENOG4105C2X	Arabinose 5-phosphate isomerase
BU251_01075	ENOG4108IUZ	ABC transporter
BU251_01080	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
BU251_01085	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
BU251_01090	ENOG4105C5R	Aminotransferase
BU251_01100	ENOG4105CGH	5'-nucleotidase
BU251_01110	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
BU251_01115	ENOG4105ER2	Ompa motb domain protein
BU251_01130	ENOG4107RFW	hydrolase family 57
BU251_01135	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
BU251_01145	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
BU251_01150	ENOG4105DZP	Membrane-associated zinc metalloprotease
BU251_01155	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
BU251_01165	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
BU251_01175	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
BU251_01180	ENOG4105CHV	Transcription elongation factor NusA
BU251_01190	ENOG4105C31	Tryptophanyl-tRNA synthetase
BU251_01195	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
BU251_01200	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
BU251_01205	ENOG4105WPN	DNA integration recombination invertion protein
BU251_01215	ENOG4105CA9	Pyruvate kinase
BU251_01225	ENOG4105JFG	SpoIID LytB domain protein
BU251_01230	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
BU251_01240	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
BU251_01245	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
BU251_01250	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
BU251_01255	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
BU251_01260	ENOG41082RQ	UPF0102 protein
BU251_01265	ENOG4105CKU	formyltetrahydrofolate synthetase
BU251_01275	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
BU251_01285	ENOG4108DNI	pyridine nucleotide-disulfide oxidoreductase
BU251_01290	ENOG4105E8X	CO dehydrogenase acetyl-CoA synthase complex beta subunit
BU251_01300	ENOG4105C2M	dna polymerase I
BU251_01305	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
BU251_01310	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
BU251_01315	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
BU251_01320	ENOG4105VFB	Binds the 23S rRNA (By similarity)
BU251_01325	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
BU251_01330	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
BU251_01335	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
BU251_01340	ENOG4105DDQ	anthranilate synthase
BU251_01345	ENOG4107QYG	anthranilate phosphoribosyltransferase
BU251_01350	ENOG4105DK0	Indole-3-glycerol phosphate synthase
BU251_01355	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
BU251_01380	ENOG4105GVR	general secretion pathway protein D
BU251_01385	ENOG4105C8J	)-transporter
BU251_01410	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
BU251_01425	ENOG4105CSA	Coproporphyrinogen iii oxidase
BU251_01455	ENOG4105CY0	Metallo-Beta-Lactamase
BU251_01465	ENOG4105EMN	RNA polymerase sigma factor
BU251_01485	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
BU251_01490	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_01510	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_01535	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
BU251_01555	ENOG4105EDK	PfkB domain protein
BU251_01565	ENOG4107QKZ	Ompa motb domain protein
BU251_01570	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
BU251_01585	ENOG4105EAH	synthase
BU251_01590	ENOG4105CEP	NADH dehydrogenase
BU251_01595	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
BU251_01600	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
BU251_01610	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
BU251_01615	ENOG4107WPW	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
BU251_01635	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
BU251_01640	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
BU251_01670	ENOG4105VC4	domain protein
BU251_01690	ENOG4107QHE	Choloylglycine hydrolase
BU251_01695	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
BU251_01700	ENOG4107SN7	NLP P60 protein
BU251_01710	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
BU251_01715	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
BU251_01720	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
BU251_01725	ENOG4105BZ8	glutamate synthase
BU251_01730	ENOG4107R37	Glutamate dehydrogenase
BU251_01735	ENOG4107R3N	Filamentation induced by cAMP protein fic
BU251_01760	ENOG41067SE	Tetr family transcriptional regulator
BU251_01770	ENOG4105CW7	secretion protein, HlyD family
BU251_01775	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
BU251_01800	ENOG4105VEQ	Cold shock protein
BU251_01855	ENOG4105CW7	secretion protein, HlyD family
BU251_01860	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
BU251_01875	ENOG4107RA4	Glycosyl transferase (Group 1
BU251_01880	ENOG4107R4J	Chloride channel
BU251_01885	ENOG4107QJZ	Glycosyl transferase, family 2
BU251_01905	ENOG4105EYF	MMPL domain protein
BU251_01930	ENOG4108YZ8	Superoxide reductase
BU251_01935	ENOG4108UM1	dedA family
BU251_01945	ENOG4105D0M	Protease HtpX homolog
BU251_01950	ENOG4105C5H	ABC transporter
BU251_01970	ENOG4108YZA	Nitrogen regulatory protein pii
BU251_01980	ENOG4105BZU	Histidine kinase
BU251_01985	ENOG4108YZA	Nitrogen regulatory protein pii
BU251_02000	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
BU251_02005	ENOG4105BZU	Histidine kinase
BU251_02015	ENOG4107QIZ	NADH dehydrogenase
BU251_02020	ENOG4107QHI	-hydrogenase
BU251_02025	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
BU251_02030	ENOG4105D41	biosynthesis protein thiH
BU251_02035	ENOG4107QW8	radical SAM domain protein
BU251_02040	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_02050	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
BU251_02075	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_02100	ENOG4108IJ2	phosphate acetyltransferase
BU251_02105	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
BU251_02110	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
BU251_02115	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
BU251_02120	ENOG4105C3M	thioredoxin reductase
BU251_02135	ENOG4105EWC	Purine nucleoside phosphorylase
BU251_02145	ENOG4106YN8	Prenyltransferase
BU251_02160	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
BU251_02170	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
BU251_02175	ENOG4108V1U	phospholipid-binding protein
BU251_02205	ENOG4105C30	Nad-dependent epimerase dehydratase
BU251_02235	ENOG4105C30	Nad-dependent epimerase dehydratase
BU251_02250	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
BU251_02265	ENOG4105F8V	Hydrolase, tatD family
BU251_02275	ENOG4105CUZ	uba thif-type nad fad binding protein
BU251_02285	ENOG4105C5X	domain protein
BU251_02300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_02310	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_02315	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
BU251_02320	ENOG4105WMR	Protein CrcB homolog
BU251_02325	ENOG4105KJJ	Uncharacterized ACR, COG1993
BU251_02335	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
BU251_02375	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
BU251_02400	ENOG4107S8C	mandelate racemase muconate lactonizing
BU251_02420	ENOG4108MUZ	hydrolase
BU251_02435	ENOG4105FA0	parb-like partition protein
BU251_02520	ENOG4105GVR	general secretion pathway protein D
BU251_02545	ENOG4107QHF	type ii secretion system protein e
BU251_02685	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
BU251_02755	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
BU251_02785	ENOG4107Y5K	Resolvase
BU251_02790	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
BU251_02795	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_02800	ENOG4105GR3	Histidine kinase
BU251_02805	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
BU251_02810	ENOG4108MGY	Histidine kinase
BU251_02815	ENOG4108U5N	UPF0316 protein
BU251_02830	ENOG4105NXH	GreA GreB family elongation factor
BU251_02885	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
BU251_02895	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
BU251_02900	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
BU251_02905	ENOG4105KNI	merR family transcriptional Regulator
BU251_02910	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
BU251_02920	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
BU251_02925	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BU251_02930	ENOG4105CFG	Acts as a chaperone (By similarity)
BU251_02935	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
BU251_02955	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
BU251_02965	ENOG4105BZU	Histidine kinase
BU251_02970	ENOG4105BZU	Histidine kinase
BU251_02980	ENOG4105DKQ	ROK family
BU251_02990	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
BU251_02995	ENOG4108IAJ	Nad-dependent epimerase dehydratase
BU251_03005	ENOG4107UVV	polysaccharide deacetylase
BU251_03015	ENOG4105WDJ	50S ribosomal protein L33
BU251_03030	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
BU251_03035	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
BU251_03040	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
BU251_03045	ENOG4107Z3D	50S ribosomal protein l10
BU251_03050	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
BU251_03055	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
BU251_03060	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
BU251_03065	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
BU251_03070	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
BU251_03075	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
BU251_03080	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
BU251_03085	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
BU251_03090	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
BU251_03095	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
BU251_03100	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
BU251_03105	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BU251_03110	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
BU251_03120	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
BU251_03125	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
BU251_03130	ENOG41082SA	50s ribosomal protein l29
BU251_03135	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
BU251_03140	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
BU251_03145	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
BU251_03155	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
BU251_03160	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
BU251_03165	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
BU251_03170	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
BU251_03175	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
BU251_03180	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
BU251_03190	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
BU251_03195	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
BU251_03200	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
BU251_03205	ENOG41067V7	50S ribosomal protein L36
BU251_03210	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BU251_03215	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
BU251_03220	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
BU251_03225	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
BU251_03230	ENOG4108ZT0	50S ribosomal protein l17
BU251_03235	ENOG4105CHM	Aminotransferase
BU251_03240	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
BU251_03245	ENOG4105CZX	twitching motility protein
BU251_03250	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
BU251_03260	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
BU251_03265	ENOG4107QN2	dihydrolipoyl dehydrogenase
BU251_03270	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
BU251_03285	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
BU251_03290	ENOG4105CHR	reductase
BU251_03305	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
BU251_03315	ENOG4105BZU	Histidine kinase
BU251_03320	ENOG4105BZU	Histidine kinase
BU251_03325	ENOG4105ETX	regulatoR
BU251_03375	ENOG4105K4W	Could be involved in septation (By similarity)
BU251_03390	ENOG410812K	response regulator receiver protein
BU251_03400	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_03420	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
BU251_03425	ENOG4105BZS	acriflavin resistance protein
BU251_03450	ENOG4106855	Competence protein
BU251_03485	ENOG4105C1J	atp-dependent rna helicase
BU251_03505	ENOG4107WD4	Releases the N-terminal proline from various substrates (By similarity)
BU251_03510	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
BU251_03530	ENOG41088YS	Glycosyl transferase (Group 1
BU251_03550	ENOG4105D64	Mechanosensitive ion channel
BU251_03565	ENOG4105DAP	Nicotinate phosphoribosyltransferase
BU251_03580	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
BU251_03585	ENOG4105CDV	Ompa motb domain protein
BU251_03620	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
BU251_03635	ENOG4105CEY	Amp-dependent synthetase and ligase
BU251_03640	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
BU251_03655	ENOG4105BZU	Histidine kinase
BU251_03670	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
BU251_03705	ENOG4105D49	3-dehydroquinate synthase
BU251_03710	ENOG4108Z4T	Peptidase M50
BU251_03725	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_03730	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
BU251_03750	ENOG41063SB	peptidase
BU251_03760	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
BU251_03765	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
BU251_03770	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
BU251_03775	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
BU251_03780	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
BU251_03785	ENOG4105CTQ	phosphohexokinase
BU251_03800	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
BU251_03810	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
BU251_03815	ENOG4105DC7	peptidase M24
BU251_03820	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
BU251_03830	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
BU251_03840	ENOG4105VCC	30S ribosomal protein S21
BU251_03850	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
BU251_03885	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
BU251_03890	ENOG4105C3F	Signal peptidase i
BU251_03895	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
BU251_03900	ENOG4105CAT	Cytidine monophosphate kinase
BU251_03910	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
BU251_03915	ENOG4105CIH	Imidazole acetol-phosphate transaminase
BU251_03920	ENOG4105CQC	Prephenate dehydratase
BU251_03925	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
BU251_03930	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
BU251_03935	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
BU251_03940	ENOG4105CDY	transcriptional regulatory protein
BU251_03980	ENOG4108TVJ	Nitroreductase
BU251_03985	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
BU251_03990	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
BU251_04005	ENOG4105BZU	Histidine kinase
BU251_04010	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
BU251_04015	ENOG4105C10	Electron transfer flavoprotein
BU251_04020	ENOG4105BZJ	Electron transfer flavoprotein
BU251_04025	ENOG4105C1G	acyl-Coa dehydrogenase
BU251_04030	ENOG4108Z1Z	gCN5-related N-acetyltransferase
BU251_04035	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
BU251_04040	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
BU251_04060	ENOG4105CP7	Triose-phosphate isomerase
BU251_04065	ENOG4105BZA	Phosphoglycerate kinase
BU251_04120	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_04175	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_04210	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_04235	ENOG4107S1W	4-alpha-glucanotransferase
BU251_04255	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
BU251_04260	ENOG4105C25	Primosomal protein n'
BU251_04265	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
BU251_04270	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
BU251_04275	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
BU251_04325	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
BU251_04330	ENOG4108IAJ	Nad-dependent epimerase dehydratase
BU251_04355	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
BU251_04375	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
BU251_04380	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
BU251_04390	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
BU251_04400	ENOG4105D3Q	Sugar transferase
BU251_04405	ENOG4106CD9	glycosyl transferase group 1
BU251_04410	ENOG4105DKP	glycosyl transferase, family 9
BU251_04425	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
BU251_04440	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
BU251_04475	ENOG4107QJE	Chromosome Partitioning Protein
BU251_04510	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
BU251_04515	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
BU251_04520	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BU251_04545	ENOG4108JPZ	Monovalent cation H antiporter subunit D
BU251_04550	ENOG4105D65	subunit l
BU251_04555	ENOG4105D65	subunit l
BU251_04570	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
BU251_04575	ENOG4105ETE	Transcriptional regulator (LacI family
BU251_04585	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
BU251_04590	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
BU251_04595	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
BU251_04605	ENOG4105DZ1	carboxypeptidase
BU251_04620	ENOG4105DCG	PHP domain protein
BU251_04625	ENOG4107SFI	Major Facilitator superfamily
BU251_04660	ENOG4105C4R	Atp-dependent dna helicase
BU251_04670	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
BU251_04675	ENOG41085HS	Involved in DNA repair and RecF pathway recombination (By similarity)
BU251_04680	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
BU251_04685	ENOG4105CTJ	Metal Dependent Phosphohydrolase
BU251_04690	ENOG4105C9A	Phoh family
BU251_04695	ENOG4109066	lysm domain bon superfamily protein
BU251_04705	ENOG4105CUT	histidyl-tRNA synthetase
BU251_04710	ENOG4105VEQ	Cold shock protein
BU251_04715	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
BU251_04720	ENOG4105C0B	DNA polymerase III (alpha subunit)
BU251_04725	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
BU251_04730	ENOG4107QVP	Dehydrogenase
BU251_04735	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
BU251_04740	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
BU251_04745	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
BU251_04755	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
BU251_04760	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
BU251_04770	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
BU251_04775	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
BU251_04780	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
BU251_04785	ENOG4105CFH	Aspartokinase
BU251_04790	ENOG4105D22	carbon starvation protein
BU251_04795	ENOG4105E3H	phosphoglycerate mutase
BU251_04805	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
BU251_04810	ENOG4105D6E	homoserine dehydrogenase
BU251_04815	ENOG4108VGI	doxx family
BU251_04830	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
BU251_04835	ENOG4105D78	K07001 NTE family protein
BU251_04845	ENOG4105M3Z	response regulator
BU251_04850	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
BU251_04855	ENOG4105BZU	Histidine kinase
BU251_04880	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
BU251_04885	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
BU251_04890	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
BU251_04905	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
BU251_04910	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
BU251_04945	ENOG4107VP5	methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase
BU251_04950	ENOG4106HYN	CO dehydrogenase acetyl-CoA synthase delta subunit
BU251_04955	ENOG41080XS	Cobyrinic acid ac-diamide synthase
BU251_04965	ENOG4105EYX	Acetyl-CoA decarbonylase synthase complex subunit gamma
BU251_04970	ENOG4105C8M	UPF0272 protein
BU251_04990	ENOG4105KT7	mgtC SapB transporter
BU251_04995	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
BU251_05000	ENOG4105PXI	polysaccharide deacetylase
BU251_05005	ENOG4105CN1	protease
BU251_05010	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
BU251_05015	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
BU251_05020	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
BU251_05025	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
BU251_05030	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
BU251_05035	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
BU251_05040	ENOG4108JA2	transcriptioN-repair coupling factor
BU251_05045	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
BU251_05050	ENOG4105VIE	preprotein translocase, subunit YajC
BU251_05055	ENOG4105K5M	30s ribosomal protein S16
BU251_05060	ENOG4105CRQ	synthase (Component I)
BU251_05065	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
BU251_05070	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
BU251_05075	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
BU251_05080	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
BU251_05085	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
BU251_05095	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
BU251_05100	ENOG410902V	Modulates RecA activity (By similarity)
BU251_05105	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
BU251_05135	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
BU251_05140	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
BU251_05150	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
BU251_05175	ENOG4106855	Competence protein
BU251_05185	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_05190	ENOG4106855	Competence protein
BU251_05200	ENOG4107QHF	type ii secretion system protein e
BU251_05205	ENOG4105E4G	Type IV pilus
BU251_05270	ENOG4108Q27	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)
BU251_05275	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
BU251_05290	ENOG4105CHM	Aminotransferase
BU251_05295	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
BU251_05300	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
BU251_05305	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
BU251_05310	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
BU251_05315	ENOG4105CH7	arginosuccinase
BU251_05320	ENOG4105CDH	Citrulline--aspartate ligase
BU251_05325	ENOG4105DBV	ornithine carbamoyltransferase
BU251_05330	ENOG4105C8Y	Acetylornithine aminotransferase
BU251_05335	ENOG4105CAS	nag kinase
BU251_05340	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
BU251_05345	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
BU251_05350	ENOG4108UJD	30S ribosomal protein S9
BU251_05355	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
BU251_05365	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
BU251_05370	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
BU251_05380	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
BU251_05385	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
BU251_05390	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
BU251_05400	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
BU251_05405	ENOG4105CHR	reductase
BU251_05410	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
BU251_05415	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
BU251_05420	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
BU251_05425	ENOG41067VY	50S ribosomal protein L32
BU251_05435	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
BU251_05440	ENOG4106H78	methyltransferase
BU251_05455	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
BU251_05475	ENOG4108VAU	general secretion pathway protein G
BU251_05510	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
BU251_05515	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
BU251_05530	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
BU251_05535	ENOG4105DJV	ribulose-phosphate 3-epimerase
BU251_05540	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
BU251_05545	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
BU251_05550	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
BU251_05555	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BU251_05560	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
BU251_05565	ENOG4105C03	ribonuclease
BU251_05575	ENOG4105E4G	Type IV pilus
BU251_05600	ENOG4108VAU	general secretion pathway protein G
BU251_05615	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_05620	ENOG4107QHF	type ii secretion system protein e
BU251_05625	ENOG4107QHF	type ii secretion system protein e
BU251_05640	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
BU251_05645	ENOG4105CNI	cell division protein FtsW
BU251_05650	ENOG4105CJN	penicillin-binding protein
BU251_05670	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
BU251_05675	ENOG4105C34	Pseudouridine synthase
BU251_05680	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
BU251_05685	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
BU251_05690	ENOG4105NHS	Transcriptional regulator, TraR DksA family
BU251_05700	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
BU251_05705	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
BU251_05715	ENOG4105DFA	alanine racemase domain protein
BU251_05730	ENOG4105CPF	Cell wall formation (By similarity)
BU251_05735	ENOG4105D4A	Cell wall formation (By similarity)
BU251_05750	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
BU251_05755	ENOG4105CNI	cell division protein FtsW
BU251_05760	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
BU251_05765	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
BU251_05770	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
BU251_05775	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
BU251_05780	ENOG4105CJN	penicillin-binding protein
BU251_05790	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
BU251_05800	ENOG4108V6E	Cell division protein mraZ
BU251_05810	ENOG4105DTN	riboflavin biosynthesis protein ribF
BU251_05815	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
BU251_05820	ENOG4105SFS	phosphoesterase RecJ domain protein
BU251_05825	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
BU251_05835	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
BU251_05840	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
BU251_05855	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
BU251_05865	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
BU251_05875	ENOG4108R6K	riboflavin synthase, subunit alpha
BU251_05880	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
BU251_05890	ENOG4105M7K	Involved in the transcription termination process (By similarity)
BU251_05895	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
BU251_05900	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
BU251_05905	ENOG4105CEV	competence damage-inducible protein
BU251_05915	ENOG410802X	bacteriophage n4 adsorption protein b
BU251_05920	ENOG4107QHF	type ii secretion system protein e
BU251_05935	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
BU251_05940	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
BU251_05950	ENOG4105CNU	cell division protein FtsK
BU251_05955	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
BU251_05960	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
BU251_05975	ENOG4105BZM	domain protein
BU251_05985	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
BU251_05990	ENOG4105VB9	50S ribosomal protein l28
BU251_05995	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
BU251_06000	ENOG4105C75	arginyL-tRNA synthetase
BU251_06010	ENOG4105C1V	Peptidase, M16
BU251_06015	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
BU251_06020	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
BU251_06040	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
BU251_06045	ENOG4108Z03	MAF-like protein
BU251_06050	ENOG4105CBX	hi0933 family
BU251_06055	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
BU251_06075	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
BU251_06080	ENOG41072GX	Peptidase M22 Glycoprotease
BU251_06090	ENOG4105K8N	protein family UPF0079, ATPase
BU251_06095	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
BU251_06100	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
BU251_06110	ENOG4105F8V	Hydrolase, tatD family
BU251_06115	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
BU251_06120	ENOG4105MA4	psp1 domain protein
BU251_06125	ENOG4107QRG	dna polymerase iii
BU251_06130	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
BU251_06135	ENOG4105C8N	cysteinyl-tRNA synthetase
BU251_06140	ENOG4105D7W	serine acetyltransferase
BU251_06145	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
BU251_06150	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
BU251_06155	ENOG4105CTP	PilT protein domain protein
BU251_06160	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
BU251_06180	ENOG4105CY3	ABC transporter, permease
BU251_06185	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
BU251_06190	ENOG41066A3	ATP guanido phosphotransferase
BU251_06195	ENOG4108Z0C	Uvrb UvrC protein
BU251_06200	ENOG4105CM2	brancheD-chain amino acid aminotransferase
BU251_06205	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
BU251_06215	ENOG4105CRK	lysyL-tRNA synthetase
BU251_06230	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
BU251_06240	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
BU251_06285	ENOG4105BZU	Histidine kinase
BU251_06295	ENOG4107QIV	Cytochrome c biogenesis protein
BU251_06310	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
BU251_06320	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
BU251_06335	ENOG4107QKA	exodeoxyribonuclease V beta
BU251_06350	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
BU251_06355	ENOG4108ZJ4	polysaccharide deacetylase
BU251_06360	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
BU251_06405	ENOG4105D7N	magnesium and cobalt transport protein CorA
BU251_06445	ENOG4105K6T	rare lipoprotein A
BU251_06470	ENOG4105CHR	reductase
BU251_06490	ENOG4105C34	Pseudouridine synthase
BU251_06510	ENOG4105ER6	polysaccharide biosynthesis protein
BU251_06515	ENOG4105CS2	ec 3.2.1.21
BU251_06520	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
BU251_06525	ENOG4105C6E	dna polymerase iii
BU251_06530	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_06550	ENOG4108Z6B	deaminase
BU251_06565	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
BU251_06585	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
BU251_06590	ENOG4105DQU	oxidoreductase, subunit beta
BU251_06595	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
BU251_06605	ENOG4105DWV	Homoserine O-trans-acetylase
BU251_06610	ENOG4105DWV	Homoserine O-trans-acetylase
BU251_06635	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
BU251_06640	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
BU251_06645	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
BU251_06650	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
BU251_06660	ENOG4105C8U	phosphate abc transporter
BU251_06665	ENOG4105CVA	phosphate
BU251_06670	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
BU251_06675	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
BU251_06680	ENOG4105E2Z	phosphate ABC transporter (Permease
BU251_06685	ENOG4105C8U	phosphate abc transporter
BU251_06690	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
BU251_06705	ENOG4105BZU	Histidine kinase
BU251_06710	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
BU251_06730	ENOG4105C09	Bile acid
BU251_06740	ENOG4105C7N	Xanthine uracil vitamin C permease
BU251_06770	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
BU251_06790	ENOG4107URF	beta-phospho-glucomutase
BU251_06795	ENOG4108RWI	nicotinamidase
BU251_06825	ENOG4105D0M	Protease HtpX homolog
BU251_06830	ENOG4108V0P	LemA family
BU251_06835	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
BU251_06840	ENOG4107QYV	phosphohexose isomerase
BU251_06850	ENOG4105CHM	Aminotransferase
BU251_06855	ENOG4108ZB6	transcriptional regulator AsnC family
BU251_06860	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
BU251_06865	ENOG4105C4K	Nad synthetase
BU251_06875	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
BU251_06880	ENOG4108VAU	general secretion pathway protein G
BU251_06890	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
BU251_06895	ENOG4105E3H	phosphoglycerate mutase
BU251_06905	ENOG4107Y2X	deaminase
BU251_07055	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
BU251_07070	ENOG4108J9M	Transporter
BU251_07075	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
BU251_07080	ENOG4105VKD	bioY protein
BU251_07085	ENOG4105D1S	lipid A biosynthesis
BU251_07110	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
BU251_07115	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
BU251_07120	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
BU251_07125	ENOG4105CZX	twitching motility protein
BU251_07135	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
BU251_07140	ENOG4105CJR	Integral membrane protein (MviN
BU251_07145	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
BU251_07165	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
BU251_07180	ENOG4105E09	nadh pyrophosphatase
BU251_07195	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
BU251_07205	ENOG4108UK2	deaminase
BU251_07210	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
BU251_07215	ENOG4108YZG	isomerase
BU251_07220	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
BU251_07225	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
BU251_07230	ENOG4107QNG	Phosphoribosylglycinamide synthetase
BU251_07245	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
BU251_07250	ENOG4108URH	decarboxylase
BU251_07255	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
BU251_07260	ENOG4105C83	adenylosuccinate lyase
BU251_07270	ENOG4108YZ4	nudix hydrolase
BU251_07285	ENOG4105C5I	Dehydrogenase
BU251_07300	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
BU251_07310	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
BU251_07315	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
BU251_07320	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BU251_07325	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BU251_07330	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
BU251_07335	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
BU251_07370	ENOG4108UXE	Protein tyrosine phosphatase
BU251_07375	ENOG4105D6J	arsenicaL-resistance protein
BU251_07380	ENOG4105VYW	UPF0251 protein
BU251_07395	ENOG4105EPH	radical SAM domain protein
BU251_07400	ENOG4108IJF	Heavy metal efflux pump, CzcA
BU251_07415	ENOG4105EPH	radical SAM domain protein
BU251_07430	ENOG4107YFT	Nadph-dependent fmn reductase
BU251_07435	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_07455	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
BU251_07470	ENOG4105EMU	Dehydrogenase
BU251_07475	ENOG4105CPP	Dehydrogenase, E1 component
BU251_07485	ENOG4105Y7M	Transcriptional regulator, TetR family
BU251_07490	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
BU251_07495	ENOG4105CW7	secretion protein, HlyD family
BU251_07525	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
BU251_07530	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
BU251_07540	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
BU251_07545	ENOG4108R3D	Electron transport complex
BU251_07550	ENOG4105DGN	Electron transport complex
BU251_07555	ENOG4105DZB	Electron transport complex
BU251_07560	ENOG4105D6A	Electron transport complex
BU251_07570	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
BU251_07600	ENOG4105KQC	Competence protein
BU251_07605	ENOG4105C8T	Leucyl-tRNA synthetase
BU251_07610	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
BU251_07660	ENOG4105EMN	RNA polymerase sigma factor
BU251_07665	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
BU251_07670	ENOG4105C8V	SAICAR synthetase
BU251_07680	ENOG4107RNI	Glucose 6-phosphate dehydrogenase effector OpcA
BU251_07685	ENOG4107RNI	Glucose 6-phosphate dehydrogenase effector OpcA
BU251_07695	ENOG4105BZU	Histidine kinase
BU251_07700	ENOG4108JJB	ABC transporter
BU251_07710	ENOG4105MRR	Transcriptional regulator (By similarity)
BU251_07745	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_07760	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
BU251_07770	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_07775	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_07780	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
BU251_07785	ENOG4108USZ	hydrogenase
BU251_07800	ENOG4107SHJ	sulfite reductase subunit b
BU251_07820	ENOG4105CQS	hydrogenase expression formation protein HypD
BU251_07830	ENOG4105C8H	hydrogenase maturation protein Hypf
BU251_07835	ENOG4105EPH	radical SAM domain protein
BU251_07850	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
BU251_07855	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
BU251_07875	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
BU251_07880	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
BU251_07915	ENOG4105C26	Dehydrogenase
BU251_07920	ENOG4105FB2	class II Aldolase
BU251_07930	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
BU251_07935	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
BU251_07950	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
BU251_07955	ENOG41069ER	domain protein
BU251_07970	ENOG4105C0P	Mg chelatase subunit ChlI
BU251_07975	ENOG4108UXN	response regulator
BU251_07980	ENOG4105BZU	Histidine kinase
BU251_07995	ENOG4105ER2	Ompa motb domain protein
BU251_08015	ENOG4105EUJ	GTP cyclohydrolase i
BU251_08020	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
BU251_08025	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
BU251_08030	ENOG4105DC1	bifunctional purine biosynthesis protein purh
BU251_08035	ENOG4105C3G	gtp-binding protein
BU251_08040	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
BU251_08045	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
BU251_08050	ENOG4105CPF	Cell wall formation (By similarity)
BU251_08060	ENOG4105CJ1	ABC, transporter
BU251_08065	ENOG4105EJU	HAD-superfamily hydrolase subfamily IA variant 3
BU251_08075	ENOG4105CWC	Acetylornithine deacetylase
BU251_08080	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
BU251_08100	ENOG4105D0M	Protease HtpX homolog
BU251_08115	ENOG4107Z5F	Aminotransferase class IV
BU251_08140	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
BU251_08145	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
BU251_08185	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_08190	ENOG4105VC4	domain protein
BU251_08220	ENOG4108WBK	V-type ATP synthase subunit D
BU251_08225	ENOG4107RQX	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
BU251_08230	ENOG4107RVI	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
BU251_08245	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
BU251_08250	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
BU251_08275	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
BU251_08280	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
BU251_08310	ENOG4105CD3	dihydroorotase
BU251_08320	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
BU251_08335	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
BU251_08340	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
BU251_08345	ENOG4108RAC	Rubrerythrin
BU251_08400	ENOG4105BZU	Histidine kinase
BU251_08410	ENOG4105GVR	general secretion pathway protein D
BU251_08440	ENOG4108VAU	general secretion pathway protein G
BU251_08460	ENOG4107QHF	type ii secretion system protein e
BU251_08470	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
BU251_08475	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
BU251_08480	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
BU251_08485	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
BU251_08495	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
BU251_08500	ENOG4105BZU	Histidine kinase
BU251_08525	ENOG4105BZU	Histidine kinase
BU251_08530	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_08535	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_08545	ENOG4105CZX	twitching motility protein
BU251_08560	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
BU251_08585	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
BU251_08590	ENOG4105E0C	molybdate abc transporter
BU251_08595	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
BU251_08620	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
BU251_08625	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
BU251_08630	ENOG4108JPZ	Monovalent cation H antiporter subunit D
BU251_08645	ENOG4108JPZ	Monovalent cation H antiporter subunit D
BU251_08680	ENOG4105DA5	(ABC) transporter
BU251_08710	ENOG4108RAC	Rubrerythrin
BU251_08715	ENOG4105VYW	UPF0251 protein
BU251_08785	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
BU251_08840	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
BU251_09015	ENOG4107Y5K	Resolvase
BU251_09045	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
BU251_09075	ENOG4105CJW	magnesium transporter
BU251_09085	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
BU251_09095	ENOG4108U5N	UPF0316 protein
BU251_09100	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_09105	ENOG4105BZU	Histidine kinase
BU251_09110	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
BU251_09125	ENOG4105K78	MarR family Transcriptional regulator
BU251_09340	ENOG4105DPH	UPF0371 protein
BU251_09355	ENOG4105BZU	Histidine kinase
BU251_09360	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
BU251_09375	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
BU251_09385	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
BU251_09390	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
BU251_09395	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
BU251_09400	ENOG4105D48	metallophosphoesterase
BU251_09410	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
BU251_09415	ENOG4107RIU	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity)
BU251_09435	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
BU251_09440	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
BU251_09450	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
BU251_09460	ENOG4107VEG	TrkA-N domain protein
BU251_09465	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
BU251_09475	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
BU251_09480	ENOG4105C22	threonyL-tRNA synthetase
BU251_09505	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
BU251_09515	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
BU251_09520	ENOG4105DSJ	YicC domain protein
BU251_09525	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
BU251_09530	ENOG4105FA0	parb-like partition protein
BU251_09535	ENOG4107QJE	Chromosome Partitioning Protein
BU251_09550	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
BU251_09555	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)