locus-tag	class	description
BU251_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BU251_00010	COG0592	DNA-directed DNA polymerase activity
BU251_00020	COG0187	DNA topoisomerase II activity
BU251_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BU251_00040	COG1910	domain protein
BU251_00050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BU251_00060	COG4964	Belongs to the GSP D family
BU251_00185	COG3459	Glycosyltransferase 36 associated
BU251_00200	COG0395	ABC-type sugar transport system, permease component
BU251_00245	COG1609	Transcriptional regulator
BU251_00275	COG4536	flavin adenine dinucleotide binding
BU251_00280	COG1253	flavin adenine dinucleotide binding
BU251_00290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BU251_00305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BU251_00310	COG0301	tRNA thio-modification
BU251_00320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BU251_00335	COG1959	2 iron, 2 sulfur cluster binding
BU251_00340	COG0693	protein deglycase activity
BU251_00355	COG1104	cysteine desulfurase activity
BU251_00405	COG0726	polysaccharide deacetylase
BU251_00420	COG1215	transferase activity, transferring glycosyl groups
BU251_00425	COG0745	RESPONSE REGULATOR receiver
BU251_00430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BU251_00455	COG1131	(ABC) transporter
BU251_00480	COG1872	DUF167
BU251_00490	COG3118	belongs to the thioredoxin family
BU251_00505	COG1324	tolerance protein
BU251_00520	COG0735	belongs to the Fur family
BU251_00535	COG0674	pyruvate-flavodoxin oxidoreductase activity
BU251_00540	COG1013	pyruvate-flavodoxin oxidoreductase activity
BU251_00545	COG1773	rubredoxin
BU251_00555	COG0426	domain, Protein
BU251_00565	COG1141	Ferredoxin
BU251_00590	COG3959	Transketolase, thiamine diphosphate binding domain
BU251_00595	COG3958	Transketolase
BU251_00600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BU251_00605	COG2088	sporulation resulting in formation of a cellular spore
BU251_00620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BU251_00625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BU251_00630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BU251_00635	COG0193	aminoacyl-tRNA hydrolase activity
BU251_00640	COG0360	Binds together with S18 to 16S ribosomal RNA
BU251_00645	COG0629	single-stranded DNA binding
BU251_00650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BU251_00655	COG0359	binds to the 23S rRNA
BU251_00660	COG0305	Participates in initiation and elongation during chromosome replication
BU251_00665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BU251_00675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BU251_00680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BU251_00680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BU251_00685	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BU251_00700	COG0731	radical SAM domain protein
BU251_00700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BU251_00720	COG2205	protein histidine kinase activity
BU251_00720	COG3437	response regulator, receiver
BU251_00720	COG3850	Histidine kinase
BU251_00720	COG4999	Histidine kinase
BU251_00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BU251_00750	COG1131	(ABC) transporter
BU251_00755	COG0842	Transport permease protein
BU251_00760	COG0842	Transport permease protein
BU251_00810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BU251_00815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BU251_00820	COG0673	inositol 2-dehydrogenase activity
BU251_00825	COG1132	(ABC) transporter
BU251_00830	COG0052	Belongs to the universal ribosomal protein uS2 family
BU251_00835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BU251_00840	COG0528	UMP kinase activity
BU251_00845	COG0233	cytoplasmic translational termination
BU251_00865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BU251_00870	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BU251_00875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BU251_00880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BU251_00885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BU251_00890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BU251_00895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BU251_00905	COG0205	6-phosphofructokinase activity
BU251_00915	COG0129	dihydroxy-acid dehydratase activity
BU251_00920	COG0028	Belongs to the TPP enzyme family
BU251_00925	COG0440	acetolactate synthase activity
BU251_00930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BU251_00935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BU251_00940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BU251_00945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BU251_00950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BU251_00955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BU251_00960	COG0758	DNA mediated transformation
BU251_00965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BU251_00970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BU251_00970	COG0646	methionine synthase
BU251_00980	COG4974	Belongs to the 'phage' integrase family
BU251_00985	COG1519	Transferase
BU251_01000	COG0438	transferase activity, transferring glycosyl groups
BU251_01005	COG0297	glycogen (starch) synthase activity
BU251_01010	COG0726	polysaccharide deacetylase
BU251_01020	COG0859	PFAM glycosyl transferase family 9
BU251_01045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BU251_01045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BU251_01050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BU251_01055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BU251_01065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BU251_01075	COG1137	ATPase activity
BU251_01080	COG0544	peptidyl-prolyl cis-trans isomerase activity
BU251_01085	COG0740	serine-type endopeptidase activity
BU251_01090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BU251_01095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BU251_01100	COG0737	Belongs to the 5'-nucleotidase family
BU251_01110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BU251_01115	COG1360	Flagellar Motor Protein
BU251_01130	COG1543	Belongs to the glycosyl hydrolase 57 family
BU251_01135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BU251_01140	COG0575	Belongs to the CDS family
BU251_01145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BU251_01150	COG0750	zinc metalloprotease
BU251_01155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BU251_01165	COG0442	prolyl-tRNA aminoacylation
BU251_01175	COG0779	Required for maturation of 30S ribosomal subunits
BU251_01180	COG0195	Participates in both transcription termination and antitermination
BU251_01190	COG0180	Tryptophanyl-tRNA synthetase
BU251_01195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BU251_01200	COG2255	four-way junction helicase activity
BU251_01205	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BU251_01215	COG0469	pyruvate kinase activity
BU251_01225	COG2385	sporulation resulting in formation of a cellular spore
BU251_01230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BU251_01240	COG0343	queuine tRNA-ribosyltransferase activity
BU251_01245	COG0336	Belongs to the RNA methyltransferase TrmD family
BU251_01250	COG0335	large ribosomal subunit rRNA binding
BU251_01260	COG0792	nuclease activity
BU251_01265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BU251_01275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BU251_01285	COG0446	pyridine nucleotide-disulphide oxidoreductase
BU251_01300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BU251_01300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BU251_01310	COG0237	dephospho-CoA kinase activity
BU251_01320	COG0254	rRNA binding
BU251_01325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BU251_01330	COG2890	protein-(glutamine-N5) methyltransferase activity
BU251_01335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BU251_01340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BU251_01340	COG0512	Glutamine amidotransferase of anthranilate synthase
BU251_01345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BU251_01350	COG0134	indole-3-glycerol-phosphate synthase activity
BU251_01355	COG0135	phosphoribosylanthranilate isomerase activity
BU251_01385	COG0733	neurotransmitter:sodium symporter activity
BU251_01410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BU251_01425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BU251_01440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BU251_01455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BU251_01485	COG0037	tRNA processing
BU251_01510	COG0521	Mo-molybdopterin cofactor biosynthetic process
BU251_01510	COG0315	cyclic pyranopterin monophosphate synthase activity
BU251_01535	COG3608	succinylglutamate desuccinylase aspartoacylase
BU251_01535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BU251_01555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BU251_01565	COG2885	chlorophyll binding
BU251_01570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BU251_01585	COG0142	geranyltranstransferase activity
BU251_01590	COG1252	NADH dehydrogenase
BU251_01595	COG0860	N-Acetylmuramoyl-L-alanine amidase
BU251_01600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BU251_01610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BU251_01615	COG0602	queuosine metabolic process
BU251_01635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BU251_01640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BU251_01670	COG2827	Endonuclease containing a URI domain
BU251_01690	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BU251_01695	COG3842	ATPase activity
BU251_01700	COG0791	NLP P60 protein
BU251_01710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BU251_01715	COG0519	Catalyzes the synthesis of GMP from XMP
BU251_01720	COG0543	2 iron, 2 sulfur cluster binding
BU251_01730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BU251_01735	COG3177	Filamentation induced by cAMP protein fic
BU251_01770	COG1566	PFAM secretion protein HlyD family protein
BU251_01775	COG2814	Major facilitator Superfamily
BU251_01800	COG1278	Cold shock
BU251_01855	COG1566	PFAM secretion protein HlyD family protein
BU251_01860	COG0577	efflux transmembrane transporter activity
BU251_01860	COG1136	(ABC) transporter
BU251_01875	COG0297	glycogen (starch) synthase activity
BU251_01875	COG0438	transferase activity, transferring glycosyl groups
BU251_01880	COG0038	chloride channel
BU251_01885	COG1215	transferase activity, transferring glycosyl groups
BU251_01905	COG2409	Drug exporters of the RND superfamily
BU251_01930	COG2033	superoxide reductase activity
BU251_01935	COG1238	metal cluster binding
BU251_01945	COG0501	Belongs to the peptidase M48B family
BU251_01965	COG0004	ammonium transporteR
BU251_01970	COG0347	Belongs to the P(II) protein family
BU251_01980	COG0004	ammonium transporteR
BU251_01985	COG0347	Belongs to the P(II) protein family
BU251_02000	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BU251_02005	COG2205	protein histidine kinase activity
BU251_02030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BU251_02035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BU251_02050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BU251_02095	COG3118	belongs to the thioredoxin family
BU251_02100	COG0280	phosphate acetyltransferase
BU251_02105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BU251_02110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BU251_02115	COG0242	peptide deformylase activity
BU251_02120	COG0492	ferredoxin-NADP+ reductase activity
BU251_02135	COG1683	Conserved Protein
BU251_02145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BU251_02160	COG0504	CTP synthase activity
BU251_02170	COG0058	SHG alpha-glucan phosphorylase activity
BU251_02175	COG1881	PFAM PEBP family protein
BU251_02200	COG0463	Glycosyl transferase, family 2
BU251_02205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_02220	COG3959	Transketolase, thiamine diphosphate binding domain
BU251_02230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_02235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_02250	COG2226	methyltransferase
BU251_02265	COG0084	hydrolase, TatD family'
BU251_02275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BU251_02285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BU251_02290	COG0396	ATPase activity
BU251_02295	COG0719	Fe-S assembly protein
BU251_02295	COG1372	Participates in initiation and elongation during chromosome replication
BU251_02300	COG0745	RESPONSE REGULATOR receiver
BU251_02310	COG0745	RESPONSE REGULATOR receiver
BU251_02315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BU251_02315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BU251_02320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BU251_02325	COG1993	acr, cog1993
BU251_02335	COG3263	regulation of cellular component size
BU251_02375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BU251_02400	COG4948	Mandelate Racemase Muconate Lactonizing
BU251_02420	COG2267	carboxylic ester hydrolase activity
BU251_02435	COG1475	DNA binding
BU251_02545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BU251_02685	COG0745	RESPONSE REGULATOR receiver
BU251_02755	COG2204	response regulator
BU251_02785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BU251_02790	COG3263	regulation of cellular component size
BU251_02795	COG0745	RESPONSE REGULATOR receiver
BU251_02800	COG2205	protein histidine kinase activity
BU251_02805	COG0704	Plays a role in the regulation of phosphate uptake
BU251_02815	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BU251_02830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BU251_02885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BU251_02895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BU251_02900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BU251_02905	COG0789	Transcriptional regulator
BU251_02910	COG0542	response to heat
BU251_02920	COG1420	regulation of RNA biosynthetic process
BU251_02925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BU251_02935	COG0484	heat shock protein binding
BU251_02955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BU251_02960	COG3842	ATPase activity
BU251_02965	COG3706	GGDEF domain
BU251_02965	COG0745	RESPONSE REGULATOR receiver
BU251_02970	COG5001	Diguanylate cyclase
BU251_02980	COG1940	carbohydrate kinase activity
BU251_02990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BU251_02995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_03015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BU251_03025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BU251_03035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BU251_03040	COG0081	regulation of translation
BU251_03045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BU251_03050	COG0222	ribosome binding
BU251_03055	COG0085	RNA polymerase activity
BU251_03060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BU251_03065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BU251_03070	COG0049	tRNA binding
BU251_03075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BU251_03080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BU251_03085	COG0051	transcription antitermination factor activity, RNA binding
BU251_03090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BU251_03095	COG0088	Forms part of the polypeptide exit tunnel
BU251_03100	COG0089	rRNA binding
BU251_03105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BU251_03110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BU251_03120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BU251_03125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BU251_03130	COG0255	Belongs to the universal ribosomal protein uL29 family
BU251_03135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BU251_03140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BU251_03145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BU251_03155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BU251_03160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BU251_03165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BU251_03170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BU251_03175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BU251_03180	COG0200	Binds to the 23S rRNA
BU251_03190	COG0563	adenylate kinase activity
BU251_03195	COG0024	Methionine aminopeptidase
BU251_03200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BU251_03205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BU251_03210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BU251_03215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BU251_03220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BU251_03225	COG0202	RNA polymerase activity
BU251_03230	COG0203	ribosomal protein L17
BU251_03235	COG0436	Aminotransferase
BU251_03240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BU251_03250	COG0066	3-isopropylmalate dehydratase activity
BU251_03260	COG0039	L-malate dehydrogenase activity
BU251_03265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BU251_03270	COG0321	lipoyl(octanoyl) transferase activity
BU251_03285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BU251_03290	COG1028	Short-chain dehydrogenase reductase Sdr
BU251_03295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BU251_03305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BU251_03315	COG3852	Histidine kinase
BU251_03320	COG5002	protein histidine kinase activity
BU251_03325	COG0745	RESPONSE REGULATOR receiver
BU251_03375	COG2088	sporulation resulting in formation of a cellular spore
BU251_03390	COG2204	response regulator
BU251_03420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BU251_03450	COG4968	Prepilin-type N-terminal cleavage methylation domain
BU251_03485	COG0513	Belongs to the DEAD box helicase family
BU251_03495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BU251_03505	COG0596	Alpha beta hydrolase
BU251_03510	COG2226	methyltransferase
BU251_03530	COG0438	transferase activity, transferring glycosyl groups
BU251_03540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BU251_03540	COG0561	phosphatase activity
BU251_03545	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BU251_03550	COG0668	transmembrane transport
BU251_03565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BU251_03580	COG1648	precorrin-2 dehydrogenase activity
BU251_03580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BU251_03620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BU251_03635	COG0318	PFAM AMP-dependent synthetase and ligase
BU251_03640	COG1968	undecaprenyl-diphosphatase activity
BU251_03655	COG3706	GGDEF domain
BU251_03670	COG0585	pseudouridine synthase activity
BU251_03705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BU251_03710	COG1994	Peptidase M50
BU251_03725	COG2199	diguanylate cyclase activity
BU251_03725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BU251_03730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BU251_03750	COG4942	peptidase
BU251_03760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BU251_03765	COG0352	thiamine-phosphate diphosphorylase activity
BU251_03770	COG0352	thiamine-phosphate diphosphorylase activity
BU251_03775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BU251_03775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BU251_03780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BU251_03785	COG0205	6-phosphofructokinase activity
BU251_03800	COG0439	Biotin carboxylase
BU251_03805	COG0511	ligase activity, forming carbon-carbon bonds
BU251_03810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BU251_03815	COG0006	proline dipeptidase activity
BU251_03830	COG1355	regulation of microtubule-based process
BU251_03840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BU251_03850	COG4206	TonB-dependent receptor
BU251_03880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BU251_03895	COG0481	GTPase activity
BU251_03900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BU251_03905	COG0287	Prephenate dehydrogenase
BU251_03910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BU251_03915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BU251_03920	COG0077	Prephenate dehydratase
BU251_03920	COG1605	Chorismate mutase
BU251_03925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BU251_03930	COG0632	four-way junction helicase activity
BU251_03940	COG0217	transcriptional regulatory protein
BU251_03980	COG0778	Nitroreductase
BU251_03985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BU251_03990	COG0358	DNA primase activity
BU251_04005	COG3706	GGDEF domain
BU251_04005	COG0745	RESPONSE REGULATOR receiver
BU251_04010	COG1196	nuclear chromosome segregation
BU251_04015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BU251_04020	COG2086	electron transfer activity
BU251_04025	COG1960	acyl-CoA dehydrogenase activity
BU251_04030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BU251_04035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BU251_04040	COG2095	MarC family integral membrane protein
BU251_04060	COG0149	triose-phosphate isomerase activity
BU251_04065	COG0126	phosphoglycerate kinase activity
BU251_04120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BU251_04175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BU251_04210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BU251_04235	COG1640	4-alpha-glucanotransferase
BU251_04255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BU251_04260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BU251_04265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BU251_04270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BU251_04275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BU251_04300	COG0463	Glycosyl transferase, family 2
BU251_04330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_04355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BU251_04375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_04385	COG0463	Glycosyl transferase, family 2
BU251_04395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_04400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BU251_04405	COG0297	glycogen (starch) synthase activity
BU251_04410	COG0859	PFAM glycosyl transferase family 9
BU251_04415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BU251_04425	COG0662	Cupin 2, conserved barrel domain protein
BU251_04425	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BU251_04440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BU251_04475	COG1192	Involved in chromosome partitioning
BU251_04510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BU251_04520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BU251_04545	COG0651	ATP synthesis coupled electron transport
BU251_04550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BU251_04550	COG2111	Na H antiporter
BU251_04570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BU251_04575	COG1609	Transcriptional regulator
BU251_04585	COG0574	Belongs to the PEP-utilizing enzyme family
BU251_04585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BU251_04590	COG0423	glycine-tRNA ligase activity
BU251_04595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BU251_04600	COG0657	acetylesterase activity
BU251_04605	COG1686	Belongs to the peptidase S11 family
BU251_04620	COG1796	DNA polymerase
BU251_04620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BU251_04625	COG2814	Major facilitator Superfamily
BU251_04670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BU251_04675	COG1381	Involved in DNA repair and RecF pathway recombination
BU251_04680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BU251_04685	COG1480	7TM receptor with intracellular HD hydrolase
BU251_04690	COG1702	phosphate starvation-inducible protein PhoH
BU251_04695	COG1652	LysM domain
BU251_04705	COG0124	histidyl-tRNA synthetase
BU251_04710	COG1278	Cold shock
BU251_04715	COG0776	regulation of translation
BU251_04725	COG0519	Catalyzes the synthesis of GMP from XMP
BU251_04725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BU251_04730	COG0516	GMP reductase activity
BU251_04735	COG0459	protein refolding
BU251_04740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BU251_04745	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BU251_04755	COG0556	nucleotide-excision repair
BU251_04760	COG0745	RESPONSE REGULATOR receiver
BU251_04775	COG0525	valine-tRNA ligase activity
BU251_04780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BU251_04785	COG0527	aspartate kinase activity
BU251_04790	COG1966	Carbon starvation protein
BU251_04795	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BU251_04805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BU251_04815	COG2259	Doxx family
BU251_04830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BU251_04835	COG1752	Esterase of the alpha-beta hydrolase superfamily
BU251_04850	COG0745	RESPONSE REGULATOR receiver
BU251_04855	COG5002	protein histidine kinase activity
BU251_04880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BU251_04880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BU251_04885	COG0736	holo-[acyl-carrier-protein] synthase activity
BU251_04890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BU251_04900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BU251_04910	COG0037	tRNA processing
BU251_04970	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BU251_04990	COG1285	pathogenesis
BU251_04995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BU251_05000	COG2861	carbohydrate metabolic process
BU251_05005	COG0793	Belongs to the peptidase S41A family
BU251_05010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BU251_05015	COG0154	amidase activity
BU251_05020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BU251_05025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BU251_05030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BU251_05035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BU251_05040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BU251_05045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BU251_05045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BU251_05050	COG1862	Preprotein translocase
BU251_05055	COG0228	four-way junction DNA binding
BU251_05065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BU251_05070	COG0107	imidazoleglycerol-phosphate synthase activity
BU251_05075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BU251_05080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BU251_05085	COG0131	Imidazoleglycerol-phosphate dehydratase
BU251_05095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BU251_05100	COG2137	regulation of response to DNA damage stimulus
BU251_05105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BU251_05135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BU251_05140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BU251_05150	COG1355	regulation of microtubule-based process
BU251_05175	COG4968	Prepilin-type N-terminal cleavage methylation domain
BU251_05185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BU251_05190	COG4968	Prepilin-type N-terminal cleavage methylation domain
BU251_05200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BU251_05250	COG0811	peptide transport
BU251_05270	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BU251_05275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BU251_05285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BU251_05290	COG0436	Aminotransferase
BU251_05295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BU251_05305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BU251_05315	COG0165	Argininosuccinate lyase
BU251_05320	COG0137	argininosuccinate synthase activity
BU251_05325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BU251_05330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BU251_05335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BU251_05340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BU251_05345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BU251_05350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BU251_05355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BU251_05365	COG0101	tRNA pseudouridine synthase activity
BU251_05370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BU251_05380	COG0473	3-isopropylmalate dehydrogenase activity
BU251_05385	COG0066	3-isopropylmalate dehydratase activity
BU251_05390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BU251_05395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BU251_05400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BU251_05405	COG1028	Short-chain dehydrogenase reductase Sdr
BU251_05410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BU251_05415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BU251_05420	COG0416	fatty acid biosynthetic process
BU251_05425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BU251_05435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BU251_05440	COG0742	ribosomal rna small subunit methyltransferase
BU251_05455	COG2226	methyltransferase
BU251_05470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BU251_05510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BU251_05530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BU251_05535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BU251_05540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BU251_05545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BU251_05550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BU251_05555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BU251_05560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BU251_05565	COG1530	ribonuclease E activity
BU251_05600	COG2165	general secretion pathway protein
BU251_05625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BU251_05640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BU251_05645	COG0772	Belongs to the SEDS family
BU251_05650	COG0768	penicillin binding
BU251_05675	COG0564	pseudouridine synthase activity
BU251_05685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BU251_05690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BU251_05700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BU251_05705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BU251_05710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BU251_05715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BU251_05730	COG1181	Belongs to the D-alanine--D-alanine ligase family
BU251_05735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BU251_05750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BU251_05755	COG0772	Belongs to the SEDS family
BU251_05760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BU251_05765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BU251_05770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BU251_05775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BU251_05790	COG0275	rRNA processing
BU251_05800	COG2001	Belongs to the MraZ family
BU251_05810	COG0196	riboflavin kinase activity
BU251_05820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BU251_05825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BU251_05835	COG0617	tRNA 3'-terminal CCA addition
BU251_05855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BU251_05865	COG1254	Belongs to the acylphosphatase family
BU251_05875	COG0307	riboflavin synthase, alpha
BU251_05880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BU251_05880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BU251_05890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BU251_05895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BU251_05900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BU251_05900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BU251_05905	COG1058	Belongs to the CinA family
BU251_05905	COG1546	Belongs to the CinA family
BU251_05915	COG1215	transferase activity, transferring glycosyl groups
BU251_05935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BU251_05940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BU251_05950	COG1674	ftsk spoiiie
BU251_05950	COG4980	gas vesicle protein
BU251_05955	COG1185	polyribonucleotide nucleotidyltransferase activity
BU251_05960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BU251_05975	COG2183	response to ionizing radiation
BU251_05985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BU251_05990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BU251_05995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BU251_05995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BU251_06000	COG0018	arginyl-trna synthetase
BU251_06005	COG0799	negative regulation of ribosome biogenesis
BU251_06010	COG0612	Peptidase, M16
BU251_06015	COG0159	tryptophan synthase activity
BU251_06020	COG0133	tryptophan synthase activity
BU251_06040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BU251_06045	COG0424	maF-like protein
BU251_06050	COG2081	HI0933 family
BU251_06055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BU251_06075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BU251_06080	COG1214	PFAM Peptidase M22, glycoprotease
BU251_06090	COG0802	atpase or kinase
BU251_06095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BU251_06105	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
BU251_06110	COG0084	hydrolase, TatD family'
BU251_06115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BU251_06115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BU251_06120	COG1774	PSP1 C-terminal conserved region
BU251_06130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BU251_06135	COG0215	cysteine-tRNA ligase activity
BU251_06140	COG1045	serine acetyltransferase
BU251_06145	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BU251_06150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BU251_06155	COG4956	integral membrane protein (PIN domain superfamily)
BU251_06160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BU251_06180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BU251_06185	COG0542	response to heat
BU251_06190	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BU251_06195	COG3880	PFAM UvrB UvrC protein
BU251_06200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BU251_06205	COG1136	(ABC) transporter
BU251_06215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BU251_06230	COG0019	diaminopimelate decarboxylase activity
BU251_06240	COG1151	hydroxylamine reductase activity
BU251_06285	COG5002	protein histidine kinase activity
BU251_06295	COG0785	Cytochrome C biogenesis protein
BU251_06300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BU251_06310	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BU251_06320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BU251_06335	COG1074	ATP-dependent DNA helicase activity
BU251_06350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BU251_06355	COG0726	polysaccharide deacetylase
BU251_06360	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BU251_06405	COG0598	Magnesium transport protein CorA
BU251_06445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BU251_06490	COG0564	pseudouridine synthase activity
BU251_06510	COG2244	polysaccharide biosynthetic process
BU251_06515	COG2723	6-phospho-beta-galactosidase activity
BU251_06525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BU251_06530	COG0745	RESPONSE REGULATOR receiver
BU251_06550	COG0590	tRNA wobble adenosine to inosine editing
BU251_06565	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BU251_06585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BU251_06590	COG1013	pyruvate-flavodoxin oxidoreductase activity
BU251_06595	COG0674	pyruvate-flavodoxin oxidoreductase activity
BU251_06605	COG2813	Specifically methylates the guanine in position
BU251_06605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BU251_06610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BU251_06635	COG1959	2 iron, 2 sulfur cluster binding
BU251_06640	COG0704	Plays a role in the regulation of phosphate uptake
BU251_06645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BU251_06650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BU251_06660	COG0573	inorganic phosphate transmembrane transporter activity
BU251_06665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BU251_06670	COG0704	Plays a role in the regulation of phosphate uptake
BU251_06675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BU251_06680	COG0581	inorganic phosphate transmembrane transporter activity
BU251_06685	COG0573	inorganic phosphate transmembrane transporter activity
BU251_06690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BU251_06705	COG5002	protein histidine kinase activity
BU251_06710	COG0745	RESPONSE REGULATOR receiver
BU251_06730	COG0385	Bile acid
BU251_06740	COG2252	PERMEase
BU251_06770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BU251_06790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BU251_06795	COG1335	isochorismatase
BU251_06815	COG0070	glutamate synthase
BU251_06815	COG0069	glutamate synthase activity
BU251_06815	COG0067	glutamate synthase
BU251_06825	COG0501	Belongs to the peptidase M48B family
BU251_06830	COG1704	LemA family
BU251_06840	COG0166	Belongs to the GPI family
BU251_06850	COG0436	Aminotransferase
BU251_06855	COG1522	sequence-specific DNA binding
BU251_06860	COG0519	Catalyzes the synthesis of GMP from XMP
BU251_06865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BU251_06865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BU251_06875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BU251_06880	COG2165	general secretion pathway protein
BU251_06890	COG0445	tRNA wobble uridine modification
BU251_06895	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BU251_06905	COG0590	tRNA wobble adenosine to inosine editing
BU251_07055	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BU251_07070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BU251_07075	COG0516	GMP reductase activity
BU251_07075	COG0517	IMP dehydrogenase activity
BU251_07080	COG1268	BioY protein
BU251_07085	COG1560	Kdo2-lipid A biosynthetic process
BU251_07110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BU251_07115	COG0653	protein targeting
BU251_07120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BU251_07135	COG0322	excinuclease ABC activity
BU251_07140	COG0728	peptidoglycan biosynthetic process
BU251_07145	COG0268	Binds directly to 16S ribosomal RNA
BU251_07165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BU251_07205	COG2131	deaminase
BU251_07210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BU251_07215	COG0698	ribose 5-phosphate isomerase
BU251_07220	COG0009	L-threonylcarbamoyladenylate synthase
BU251_07225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BU251_07230	COG0151	Belongs to the GarS family
BU251_07240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BU251_07245	COG0047	phosphoribosylformylglycinamidine synthase activity
BU251_07250	COG1611	Belongs to the LOG family
BU251_07255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BU251_07260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BU251_07270	COG0494	nUDIX hydrolase
BU251_07285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BU251_07300	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BU251_07310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BU251_07315	COG0509	glycine decarboxylation via glycine cleavage system
BU251_07325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BU251_07330	COG0095	Lipoate-protein ligase
BU251_07370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BU251_07375	COG0798	PFAM Bile acid sodium symporter
BU251_07380	COG1342	Belongs to the UPF0251 family
BU251_07395	COG1032	radical SAM domain protein
BU251_07400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BU251_07415	COG1032	radical SAM domain protein
BU251_07430	COG0431	NADPH-dependent FMN reductase
BU251_07470	COG4221	oxidoreductase activity
BU251_07475	COG0508	dehydrogenase complex catalyzes the overall conversion of
BU251_07475	COG0022	dehydrogenase e1 component
BU251_07485	COG1309	transcriptional regulator
BU251_07495	COG1566	PFAM secretion protein HlyD family protein
BU251_07525	COG0148	phosphopyruvate hydratase activity
BU251_07530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BU251_07540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BU251_07545	COG2878	Part of a membrane complex involved in electron transport
BU251_07550	COG4657	Part of a membrane complex involved in electron transport
BU251_07555	COG4660	Part of a membrane complex involved in electron transport
BU251_07560	COG4658	electron transport chain
BU251_07570	COG4656	Part of a membrane complex involved in electron transport
BU251_07595	COG0811	peptide transport
BU251_07600	COG1596	polysaccharide export
BU251_07600	COG1555	photosystem II stabilization
BU251_07605	COG0495	leucyl-tRNA aminoacylation
BU251_07610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BU251_07665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BU251_07670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BU251_07680	COG3429	Glucose-6-phosphate dehydrogenase subunit
BU251_07680	COG3409	Peptidoglycan-binding domain 1 protein
BU251_07685	COG3409	Peptidoglycan-binding domain 1 protein
BU251_07685	COG3429	Glucose-6-phosphate dehydrogenase subunit
BU251_07695	COG0745	RESPONSE REGULATOR receiver
BU251_07695	COG3706	GGDEF domain
BU251_07700	COG1122	ATPase activity
BU251_07710	COG0864	Transcriptional regulator
BU251_07740	COG1187	pseudouridine synthase activity
BU251_07755	COG0824	Thioesterase
BU251_07760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BU251_07770	COG0315	cyclic pyranopterin monophosphate synthase activity
BU251_07775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BU251_07780	COG0303	'Molybdopterin
BU251_07785	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BU251_07795	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
BU251_07835	COG1032	radical SAM domain protein
BU251_07855	COG2814	Major facilitator Superfamily
BU251_07875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BU251_07880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BU251_07920	COG0235	Class ii aldolase
BU251_07930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BU251_07935	COG0813	purine-nucleoside phosphorylase activity
BU251_07940	COG0318	PFAM AMP-dependent synthetase and ligase
BU251_07950	COG0825	malonyl-CoA metabolic process
BU251_07955	COG3584	3D domain protein
BU251_07955	COG1388	LysM domain
BU251_07960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BU251_07970	COG0606	chelatase, subunit chli
BU251_07975	COG0784	Response regulator, receiver
BU251_07980	COG5002	protein histidine kinase activity
BU251_07995	COG1360	Flagellar Motor Protein
BU251_08015	COG0302	gtp cyclohydrolase
BU251_08020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BU251_08025	COG0285	dihydrofolate synthase activity
BU251_08030	COG0138	bifunctional purine biosynthesis protein purh
BU251_08035	COG0012	GTP binding
BU251_08040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BU251_08045	COG1509	lysine 2,3-aminomutase activity
BU251_08050	COG1181	Belongs to the D-alanine--D-alanine ligase family
BU251_08060	COG1131	(ABC) transporter
BU251_08065	COG1011	Hydrolase
BU251_08075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BU251_08080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BU251_08100	COG0501	Belongs to the peptidase M48B family
BU251_08115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BU251_08140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BU251_08140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BU251_08145	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BU251_08190	COG2827	Endonuclease containing a URI domain
BU251_08225	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
BU251_08230	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BU251_08245	COG0284	orotidine-5'-phosphate decarboxylase activity
BU251_08275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BU251_08280	COG0505	Belongs to the CarA family
BU251_08320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BU251_08335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BU251_08340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BU251_08345	COG1592	Rubrerythrin
BU251_08400	COG4585	Histidine kinase
BU251_08420	COG3409	Peptidoglycan-binding domain 1 protein
BU251_08420	COG3267	Type II secretory pathway component ExeA
BU251_08460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BU251_08470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BU251_08475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BU251_08480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BU251_08485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BU251_08495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BU251_08500	COG3706	GGDEF domain
BU251_08500	COG0745	RESPONSE REGULATOR receiver
BU251_08525	COG5002	protein histidine kinase activity
BU251_08535	COG0745	RESPONSE REGULATOR receiver
BU251_08560	COG0310	cobalt ion transport
BU251_08585	COG3842	ATPase activity
BU251_08620	COG3260	NADH ubiquinone oxidoreductase 20
BU251_08625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BU251_08625	COG0649	NAD binding
BU251_08625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BU251_08630	COG0651	ATP synthesis coupled electron transport
BU251_08645	COG0651	ATP synthesis coupled electron transport
BU251_08680	COG1131	(ABC) transporter
BU251_08685	COG1215	transferase activity, transferring glycosyl groups
BU251_08710	COG1592	Rubrerythrin
BU251_08715	COG1342	Belongs to the UPF0251 family
BU251_08840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BU251_09015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BU251_09045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BU251_09075	COG2239	Acts as a magnesium transporter
BU251_09085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BU251_09095	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BU251_09100	COG0745	RESPONSE REGULATOR receiver
BU251_09105	COG5002	protein histidine kinase activity
BU251_09110	COG0745	RESPONSE REGULATOR receiver
BU251_09125	COG3189	MarR family transcriptional regulator
BU251_09340	COG4868	Belongs to the UPF0371 family
BU251_09355	COG3300	MHYT domain
BU251_09355	COG5001	Diguanylate cyclase
BU251_09375	COG0674	pyruvate-flavodoxin oxidoreductase activity
BU251_09385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BU251_09390	COG1722	exodeoxyribonuclease VII activity
BU251_09395	COG1570	exodeoxyribonuclease VII activity
BU251_09400	COG1692	metallophosphoesterase
BU251_09410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BU251_09415	COG0822	iron-sulfur transferase activity
BU251_09435	COG0072	phenylalanine-tRNA ligase activity
BU251_09440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BU251_09450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BU251_09460	COG0569	domain protein
BU251_09475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BU251_09480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BU251_09505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BU251_09520	COG1561	YicC-like family, N-terminal region
BU251_09525	COG0105	UTP biosynthetic process
BU251_09530	COG1475	DNA binding
BU251_09535	COG1192	Involved in chromosome partitioning