locus-tag class description VAPA_1c00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) VAPA_1c00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) VAPA_1c00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAPA_1c00080 ENOG4107RN3 metallophosphoesterase VAPA_1c00100 ENOG41061N2 exported protein VAPA_1c00110 ENOG4107UXM Membrane VAPA_1c00120 ENOG4105DZQ phospholipase D Transphosphatidylase VAPA_1c00130 ENOG4105X23 Endonuclease Exonuclease phosphatase VAPA_1c00170 ENOG4105EUB pirin domain protein VAPA_1c00190 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase VAPA_1c00230 ENOG4105CT7 inner membrane cred family protein VAPA_1c00240 ENOG4108JQC penicillin-binding protein 1A VAPA_1c00260 ENOG4105EB3 Histidine kinase VAPA_1c00270 ENOG4105E3W Two component transcriptional regulator (Winged helix family VAPA_1c00300 ENOG410681U heavy metal transport detoxification protein VAPA_1c00310 ENOG4105C59 p-type ATPase VAPA_1c00320 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) VAPA_1c00330 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VAPA_1c00360 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_1c00370 ENOG4105ECM Sensor protein basS pmrB VAPA_1c00380 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VAPA_1c00410 ENOG4108K3A Glutathione S-transferase VAPA_1c00440 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VAPA_1c00450 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) VAPA_1c00470 ENOG4107QJE Chromosome Partitioning Protein VAPA_1c00510 ENOG4105CQB FAD linked oxidase domain protein VAPA_1c00530 ENOG4108WBT adenosyltransferase VAPA_1c00600 ENOG4107R11 Transcriptional regulator VAPA_1c00640 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) VAPA_1c00650 ENOG4107QMS site-determining protein VAPA_1c00660 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) VAPA_1c00670 ENOG4105C2W permease VAPA_1c00680 ENOG4105KA0 thioesterase Superfamily protein VAPA_1c00730 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAPA_1c00740 ENOG4105CD3 dihydroorotase VAPA_1c00760 ENOG41079KZ Major Facilitator Superfamily VAPA_1c00790 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) VAPA_1c00810 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme VAPA_1c00840 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VAPA_1c00850 ENOG4108IV0 ABC, transporter VAPA_1c00860 ENOG4105C0Z ABC transporter VAPA_1c00880 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c00940 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) VAPA_1c01040 ENOG4105C3M thioredoxin reductase VAPA_1c01070 ENOG4107XCH Cyclase family VAPA_1c01080 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component VAPA_1c01090 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VAPA_1c01130 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VAPA_1c01140 ENOG4108T5G Adenylate VAPA_1c01170 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c01190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c01210 ENOG4108ERU trap dicarboxylate transporter subunit DctP VAPA_1c01220 ENOG41069M3 Transcriptional regulator VAPA_1c01250 ENOG41082T9 Membrane VAPA_1c01260 ENOG4105ETT transcriptional Regulator, LysR family VAPA_1c01270 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c01280 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c01320 ENOG4108RG0 uracil-dna glycosylase VAPA_1c01380 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme VAPA_1c01390 ENOG4105CHR reductase VAPA_1c01440 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c01460 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein VAPA_1c01470 ENOG4105FAE von Willebrand factor, type A VAPA_1c01490 ENOG4105DWV Homoserine O-trans-acetylase VAPA_1c01510 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) VAPA_1c01520 ENOG4108IV0 ABC, transporter VAPA_1c01530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c01540 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c01550 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c01560 ENOG41083Z3 extracellular ligand-binding receptor VAPA_1c01600 ENOG4105CSV Glutaminase VAPA_1c01650 ENOG4107RZC phospholipase d VAPA_1c01670 ENOG4108IV0 ABC, transporter VAPA_1c01680 ENOG4105C0Z ABC transporter VAPA_1c01710 ENOG4105CAD extracellular ligand-binding receptor VAPA_1c01720 ENOG4107Z7P Ferredoxin VAPA_1c01800 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) VAPA_1c01820 ENOG4105C7B Threonine dehydratase VAPA_1c01860 ENOG4105C9U ATP-dependent DNA helicase RecQ VAPA_1c01880 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VAPA_1c01900 ENOG4105CZE histidine utilization repressor VAPA_1c01910 ENOG4105C84 Histidine ammonia-lyase VAPA_1c01920 ENOG4105CGP Urocanate hydratase VAPA_1c01930 ENOG4105CIF Ornithine Cyclodeaminase VAPA_1c01970 ENOG4105EAB amino acid AbC transporter VAPA_1c01980 ENOG4105E5Q amino acid AbC transporter VAPA_1c01990 ENOG41090B9 response to stress VAPA_1c02000 ENOG4105CI2 imidazolone-5-propionate hydrolase VAPA_1c02010 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) VAPA_1c02030 ENOG4105C3R Methionine synthase VAPA_1c02050 ENOG4105F52 Transcriptional regulator VAPA_1c02070 ENOG4105C3R Methionine synthase VAPA_1c02080 ENOG41063ZV VAPA_1c02090 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 VAPA_1c02120 ENOG4108W9H Tetr family transcriptional regulator VAPA_1c02130 ENOG4105DP0 ferredoxin-NADP reductase VAPA_1c02190 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c02200 ENOG4105C0Z ABC transporter VAPA_1c02210 ENOG4108IV0 ABC, transporter VAPA_1c02220 ENOG4108RWI nicotinamidase VAPA_1c02240 ENOG4108XHQ (2Fe-2S)-binding domain protein VAPA_1c02250 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding VAPA_1c02350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAPA_1c02360 ENOG4105CS6 Rhs element vgr protein VAPA_1c02470 ENOG4106VK6 Flagellar motor protein VAPA_1c02510 ENOG4107QPV Serine Threonine protein kinase VAPA_1c02530 ENOG4105E5H Transposase VAPA_1c02540 ENOG4108YXQ IS66 Orf2 family protein VAPA_1c02650 ENOG4105CS6 Rhs element vgr protein VAPA_1c02740 ENOG4105C0P Mg chelatase subunit ChlI VAPA_1c02760 ENOG4108YZA Nitrogen regulatory protein pii VAPA_1c02770 ENOG4105BZU Histidine kinase VAPA_1c02790 ENOG4105W8I Transcriptional regulator VAPA_1c02800 ENOG4105CQB FAD linked oxidase domain protein VAPA_1c02810 ENOG4105EU8 FAD linked oxidase domain protein VAPA_1c02820 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) VAPA_1c02840 ENOG4108V06 Glutathione peroxidase VAPA_1c02860 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) VAPA_1c02870 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VAPA_1c02890 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VAPA_1c02900 ENOG4105MP9 class II Aldolase VAPA_1c02910 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c02920 ENOG4105C01 Dihydroxy-acid dehydratase VAPA_1c02960 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase VAPA_1c02970 ENOG4105C26 Dehydrogenase VAPA_1c02980 ENOG4105ERH Fumarylacetoacetate hydrolase VAPA_1c03000 ENOG4108V8F Transcriptional regulator, MarR family VAPA_1c03020 ENOG4105CNA YD repeat protein VAPA_1c03040 ENOG4105CS6 Rhs element vgr protein VAPA_1c03050 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) VAPA_1c03070 ENOG4106KR7 LysR family Transcriptional regulator VAPA_1c03080 ENOG4105CSH Transporter VAPA_1c03090 ENOG4105CH2 amidohydrolase VAPA_1c03100 ENOG4105DH7 May be involved in recombination (By similarity) VAPA_1c03110 ENOG4105CM2 brancheD-chain amino acid aminotransferase VAPA_1c03150 ENOG4105E0F Histidine kinase VAPA_1c03170 ENOG4105D5U fad dependent oxidoreductase VAPA_1c03200 ENOG4105EYM Major Facilitator superfamily VAPA_1c03230 ENOG4105C26 Dehydrogenase VAPA_1c03250 ENOG4105GVF (ABC) transporter VAPA_1c03260 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VAPA_1c03320 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) VAPA_1c03330 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) VAPA_1c03340 ENOG4108JQ9 ABC transporter VAPA_1c03380 ENOG41061H0 Monooxygenase VAPA_1c03390 ENOG4105F04 LysR family Transcriptional regulator VAPA_1c03400 ENOG4105CGK Exodeoxyribonuclease III VAPA_1c03410 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) VAPA_1c03430 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c03440 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c03450 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c03460 ENOG4105DFF Rod shape-determining protein mreb VAPA_1c03490 ENOG4105CJN penicillin-binding protein VAPA_1c03510 ENOG4105F1J Homogentisate 1,2-dioxygenase VAPA_1c03530 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase VAPA_1c03560 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) VAPA_1c03630 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c03650 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c03680 ENOG41080HI glycine oxidase VAPA_1c03710 ENOG4105D38 putrescine abc transporter VAPA_1c03720 ENOG4105F38 ABC transporter, permease VAPA_1c03730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c03770 ENOG4105CHM Aminotransferase VAPA_1c03800 ENOG4105EJ9 Membrane VAPA_1c03840 ENOG4105VFU Rna-binding protein VAPA_1c03870 ENOG4105C1J atp-dependent rna helicase VAPA_1c03880 ENOG4107QX8 SPFH domain, Band 7 family protein VAPA_1c03890 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c03900 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c03930 ENOG4107QX3 carboxylase VAPA_1c03940 ENOG4105BZU Histidine kinase VAPA_1c03960 ENOG4106BRA Membrane VAPA_1c03970 ENOG4105CWC Acetylornithine deacetylase VAPA_1c03980 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase VAPA_1c03990 ENOG4105CH2 amidohydrolase VAPA_1c04020 ENOG4108J2R molybdopterin oxidoreductase VAPA_1c04050 ENOG4105CHR reductase VAPA_1c04060 ENOG4105CMG Carbohydrate kinase VAPA_1c04070 ENOG4105CPQ Dehydrogenase VAPA_1c04080 ENOG4105CNN ABC, transporter VAPA_1c04100 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VAPA_1c04110 ENOG4108W3Q Transcriptional regulator VAPA_1c04120 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c04210 ENOG4105MSY salicylate hydroxylase VAPA_1c04250 ENOG4105C29 acyl-CoA thioesterase VAPA_1c04270 ENOG4105CHR reductase VAPA_1c04290 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c04300 ENOG4105CF8 branched-chain amino acid ABC transporter, permease VAPA_1c04310 ENOG4105C0Z ABC transporter VAPA_1c04320 ENOG4108IV0 ABC, transporter VAPA_1c04330 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase VAPA_1c04350 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein VAPA_1c04360 ENOG4107MKT Stringent starvation protein a VAPA_1c04370 ENOG4108R85 Short chain dehydrogenase VAPA_1c04380 ENOG4105CHH sulfate transporter VAPA_1c04400 ENOG4105C2J ABC transporter VAPA_1c04410 ENOG4105C0Z ABC transporter VAPA_1c04420 ENOG4105CF8 branched-chain amino acid ABC transporter, permease VAPA_1c04430 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c04450 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VAPA_1c04470 ENOG41061GT Aldolase VAPA_1c04480 ENOG4108FN7 Aldo keto reductase VAPA_1c04490 ENOG4105CNN ABC, transporter VAPA_1c04520 ENOG4105CMG Carbohydrate kinase VAPA_1c04540 ENOG4105FDP GntR family transcriptional regulator VAPA_1c04570 ENOG4108UUM single-stranded DNA-binding protein VAPA_1c04600 ENOG4105CDY transcriptional regulatory protein VAPA_1c04630 ENOG4105DEN Luciferase family VAPA_1c04640 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) VAPA_1c04680 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VAPA_1c04690 ENOG4105W8H transhydrogenase (subunit alpha VAPA_1c04700 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VAPA_1c04710 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c04720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAPA_1c04730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_1c04740 ENOG4105C3U ABC transporter VAPA_1c04750 ENOG4108JQ7 (ABC) transporter VAPA_1c04770 ENOG4105DEF Extracellular solute-binding protein, family 5 VAPA_1c04780 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) VAPA_1c04790 ENOG4107QUT magnesium and cobalt transport protein CorA VAPA_1c04810 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA VAPA_1c04820 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN VAPA_1c04830 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) VAPA_1c04840 ENOG41090R7 Ferric uptake VAPA_1c04850 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VAPA_1c04860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) VAPA_1c04880 ENOG4105SG9 biopolymer transport protein, ExbD VAPA_1c04910 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) VAPA_1c04920 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) VAPA_1c04930 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VAPA_1c04940 ENOG4108IUM Glycogen debranching enzyme VAPA_1c04950 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) VAPA_1c04960 ENOG4105CG3 alpha amylase, catalytic region VAPA_1c04970 ENOG4105E1J oxidoreductase VAPA_1c05020 ENOG4105C8T Leucyl-tRNA synthetase VAPA_1c05050 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) VAPA_1c05070 ENOG4105DFH Transport of potassium into the cell (By similarity) VAPA_1c05110 ENOG4105DKK Benzoate VAPA_1c05120 ENOG4105D7Z glutathione synthase VAPA_1c05150 ENOG4105E7A Glutamine amidotransferase VAPA_1c05170 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAPA_1c05200 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 VAPA_1c05220 ENOG4108UKI Enoyl-CoA hydratase VAPA_1c05230 ENOG4105F2C Acetyl-CoA acetyltransferase VAPA_1c05250 ENOG4105ETT transcriptional Regulator, LysR family VAPA_1c05300 ENOG4107QP3 malate synthase g VAPA_1c05320 ENOG4107258 Transcriptional regulator VAPA_1c05330 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase VAPA_1c05340 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c05410 ENOG4105C75 arginyL-tRNA synthetase VAPA_1c05430 ENOG4108Z33 Thiol disulfide Interchange Protein VAPA_1c05440 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA VAPA_1c05450 ENOG4108IUZ ABC transporter VAPA_1c05460 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAPA_1c05470 ENOG4107RZC phospholipase d VAPA_1c05530 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) VAPA_1c05590 ENOG4105CBC glutamate synthase VAPA_1c05600 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VAPA_1c05650 ENOG4108ZAI phosphatidylglycerophosphatase a VAPA_1c05680 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) VAPA_1c05690 ENOG4108W2Y isochorismatase VAPA_1c05710 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) VAPA_1c05740 ENOG4105NWN ApaG protein VAPA_1c05750 ENOG4105DJV ribulose-phosphate 3-epimerase VAPA_1c05780 ENOG4105FDF Could be involved in DNA repair (By similarity) VAPA_1c05790 ENOG4105DQE DNA ligase VAPA_1c05870 ENOG4108YBA Histidine kinase VAPA_1c05890 ENOG4105BZU Histidine kinase VAPA_1c05900 ENOG4105EHI Phosphonate ABC transporter, periplasmic VAPA_1c05910 ENOG4105EHI Phosphonate ABC transporter, periplasmic VAPA_1c05930 ENOG4106VK6 Flagellar motor protein VAPA_1c05960 ENOG4105D9P serine threonine protein kinase VAPA_1c06070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAPA_1c06080 ENOG4105CS6 Rhs element vgr protein VAPA_1c06130 ENOG4105CS6 Rhs element vgr protein VAPA_1c06240 ENOG4108WC9 type VI secretion system effector, hcp1 family VAPA_1c06320 ENOG4105H3G oxidoreductase VAPA_1c06400 ENOG4107SQD Transcriptional regulator, GntR family VAPA_1c06560 ENOG4108VVQ metallophosphoesterase VAPA_1c06600 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c06610 ENOG4108M9J MaoC like domain protein VAPA_1c06640 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_1c06650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c06670 ENOG41061CK Antibiotic biosynthesis monooxygenase VAPA_1c06680 ENOG4106KED esterase YpfH VAPA_1c06720 ENOG4105CC0 LysR family Transcriptional regulator VAPA_1c06730 ENOG410903C (LipO)protein VAPA_1c06790 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_1c06830 ENOG4105DEQ transcriptional regulator VAPA_1c06850 ENOG4107YUH hydrolase VAPA_1c06870 ENOG4108IV0 ABC, transporter VAPA_1c06880 ENOG4105C0Z ABC transporter VAPA_1c06890 ENOG4108HWW ABC transporter VAPA_1c06920 ENOG4106KR7 LysR family Transcriptional regulator VAPA_1c06970 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) VAPA_1c07060 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) VAPA_1c07080 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VAPA_1c07110 ENOG4106IQC argininosuccinate lyase VAPA_1c07140 ENOG4105RE0 Asp Glu hydantoin racemase VAPA_1c07150 ENOG4106NZI LysR family Transcriptional regulator VAPA_1c07210 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VAPA_1c07250 ENOG4105DDQ anthranilate synthase VAPA_1c07270 ENOG4108NIW Leucine export protein LeuE VAPA_1c07280 ENOG4107QYG anthranilate phosphoribosyltransferase VAPA_1c07290 ENOG4105DK0 Indole-3-glycerol phosphate synthase VAPA_1c07300 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) VAPA_1c07340 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VAPA_1c07380 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) VAPA_1c07390 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) VAPA_1c07400 ENOG4108VZM 50s ribosomal protein L10 VAPA_1c07410 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) VAPA_1c07420 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VAPA_1c07430 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VAPA_1c07450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VAPA_1c07470 ENOG4105ES5 Histidine kinase VAPA_1c07540 ENOG4105C8Q Methyl-accepting chemotaxis VAPA_1c07640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c07660 ENOG4105EXG Transcriptional regulator VAPA_1c07670 ENOG4105K70 DNA-binding protein VAPA_1c07680 ENOG4105F04 LysR family Transcriptional regulator VAPA_1c07720 ENOG4105BZU Histidine kinase VAPA_1c07730 ENOG4105BZU Histidine kinase VAPA_1c07740 ENOG4107RA1 nh(3)-dependent nad( ) synthetase VAPA_1c07750 ENOG4105HDD phospholipase VAPA_1c07770 ENOG4105C4R Atp-dependent dna helicase VAPA_1c07780 ENOG4105RK9 auxin efflux carrier VAPA_1c07810 ENOG4105C25 Primosomal protein n' VAPA_1c07820 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) VAPA_1c07840 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VAPA_1c07900 ENOG4105EJC lysr family transcriptional regulator VAPA_1c07910 ENOG4105DTD Dehydrogenase VAPA_1c07930 ENOG4105CND Glycosyl transferase, family 2 VAPA_1c07940 ENOG4107BJW polysaccharide deacetylase VAPA_1c08010 ENOG410829K Lysine exporter protein (Lyse ygga) VAPA_1c08030 ENOG4105JAB phenazine biosynthesis protein, phzf family VAPA_1c08040 ENOG4108TGY Glutathione S-transferase VAPA_1c08050 ENOG4108NIW Leucine export protein LeuE VAPA_1c08070 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAPA_1c08080 ENOG4105T38 integral membrane protein VAPA_1c08130 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_1c08150 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase VAPA_1c08170 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase VAPA_1c08180 ENOG4107TVC Glycosyl transferase, family 2 VAPA_1c08230 ENOG4108DMA Nad-dependent epimerase dehydratase VAPA_1c08240 ENOG4105C0K Gdp-mannose 4,6-dehydratase VAPA_1c08250 ENOG4107RGC Glycosyl transferase, family 2 VAPA_1c08280 ENOG4105CJT Mannose-1-phosphate guanylyltransferase VAPA_1c08300 ENOG4105K64 Glycosyl transferase, family 2 VAPA_1c08320 ENOG4105EXC Acyl-transferase VAPA_1c08340 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) VAPA_1c08350 ENOG4105CAS nag kinase VAPA_1c08380 ENOG4105CMR udp-glucose 4-epimerase VAPA_1c08390 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) VAPA_1c08430 ENOG4105DG4 malate L-lactate dehydrogenase VAPA_1c08440 ENOG4105CTX dehydratase VAPA_1c08450 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c08470 ENOG4108ERU trap dicarboxylate transporter subunit DctP VAPA_1c08480 ENOG4107YCY Transcriptional regulator VAPA_1c08490 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr VAPA_1c08500 ENOG4106517 Short-chain dehydrogenase reductase Sdr VAPA_1c08520 ENOG4105FDP GntR family transcriptional regulator VAPA_1c08530 ENOG41083Z3 extracellular ligand-binding receptor VAPA_1c08540 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c08550 ENOG4105CF8 branched-chain amino acid ABC transporter, permease VAPA_1c08560 ENOG4105C0Z ABC transporter VAPA_1c08570 ENOG4108IV0 ABC, transporter VAPA_1c08590 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAPA_1c08600 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAPA_1c08680 ENOG4105EJC lysr family transcriptional regulator VAPA_1c08690 ENOG4107GJV short-chain dehydrogenase reductase VAPA_1c08710 ENOG4105CSU acyl-Coa dehydrogenase VAPA_1c08740 ENOG4105WDY DNA (cytosine-5-)-methyltransferase VAPA_1c08750 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c08780 ENOG4105CHR reductase VAPA_1c08800 ENOG41060WC Enoyl-CoA hydratase VAPA_1c08810 ENOG4105CAD extracellular ligand-binding receptor VAPA_1c08820 ENOG4105NAU thioesterase Superfamily protein VAPA_1c08830 ENOG4108JJ7 ABC transporter VAPA_1c08840 ENOG4105C5I Dehydrogenase VAPA_1c08850 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c08860 ENOG4107YNJ LysR family Transcriptional regulator VAPA_1c08870 ENOG4108IJ0 Aspartate ammonia-lyase VAPA_1c08880 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c08890 ENOG4105EAD ABC transporter VAPA_1c08900 ENOG4105DRP amino acid AbC transporter VAPA_1c08910 ENOG4105CDA abc transporter atp-binding protein VAPA_1c08920 ENOG4105DU0 nucleoside hydrolase VAPA_1c08930 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_1c08940 ENOG4105EKQ RNA-directed DNA polymerase VAPA_1c08950 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c08960 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ VAPA_1c08980 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c09000 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c09010 ENOG4105E39 Enoyl-CoA hydratase VAPA_1c09020 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c09030 ENOG4105CC9 acyl-Coa dehydrogenase VAPA_1c09040 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c09050 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAPA_1c09060 ENOG4105CBN LysR family transcriptional regulator VAPA_1c09110 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c09130 ENOG4108JQ7 (ABC) transporter VAPA_1c09140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_1c09150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAPA_1c09160 ENOG4105DEF Extracellular solute-binding protein, family 5 VAPA_1c09180 ENOG4105W7K Transcriptional regulator VAPA_1c09190 ENOG4105EKE dihydroorotase VAPA_1c09220 ENOG4105D0M Protease HtpX homolog VAPA_1c09240 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) VAPA_1c09250 ENOG4105EW6 flavin reductase domain protein, FMN-binding VAPA_1c09260 ENOG4105DZ0 fad dependent oxidoreductase VAPA_1c09280 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) VAPA_1c09300 ENOG4105ZQC membrane protein AaeX VAPA_1c09310 ENOG4105Y49 secretion protein, HlyD family VAPA_1c09330 ENOG4105C2C drug resistance transporter, Bcr CflA VAPA_1c09350 ENOG4105FE9 pseudouridine synthase VAPA_1c09360 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) VAPA_1c09440 ENOG4105HSS phospholipase C VAPA_1c09460 ENOG4105CV8 reductase VAPA_1c09470 ENOG4105F27 Major Facilitator VAPA_1c09520 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) VAPA_1c09550 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VAPA_1c09560 ENOG4105DR4 Methyltransferase VAPA_1c09570 ENOG4105CKI cobalamin synthesis protein VAPA_1c09590 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters VAPA_1c09610 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) VAPA_1c09620 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) VAPA_1c09630 ENOG4108V6E Cell division protein mraZ VAPA_1c09640 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) VAPA_1c09650 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VAPA_1c09660 ENOG4105CJN penicillin-binding protein VAPA_1c09670 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) VAPA_1c09680 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) VAPA_1c09690 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) VAPA_1c09700 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) VAPA_1c09710 ENOG4105CNI cell division protein FtsW VAPA_1c09720 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) VAPA_1c09730 ENOG4105DFU Cell wall formation (By similarity) VAPA_1c09740 ENOG4105CPF Cell wall formation (By similarity) VAPA_1c09750 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) VAPA_1c09760 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) VAPA_1c09770 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) VAPA_1c09780 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAPA_1c09800 ENOG4105ETT transcriptional Regulator, LysR family VAPA_1c09820 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) VAPA_1c09830 ENOG4105KNE Phosphatidate cytidylyltransferase VAPA_1c09870 ENOG4105E2X shikimate dehydrogenase VAPA_1c09890 ENOG4108I1Z Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) VAPA_1c09900 ENOG4105IPS esterase VAPA_1c09910 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c09930 ENOG4105CNI cell division protein FtsW VAPA_1c09940 ENOG4105D1U peptidase U62 modulator of DNA gyrase VAPA_1c09960 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VAPA_1c09980 ENOG4105DFU Cell wall formation (By similarity) VAPA_1c10000 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VAPA_1c10010 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein VAPA_1c10020 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VAPA_1c10030 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) VAPA_1c10070 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VAPA_1c10080 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VAPA_1c10100 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAPA_1c10110 ENOG4107TUY Histidine kinase VAPA_1c10140 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY VAPA_1c10170 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) VAPA_1c10190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAPA_1c10210 ENOG4107WP9 Histidine kinase VAPA_1c10220 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VAPA_1c10250 ENOG4105BZS acriflavin resistance protein VAPA_1c10280 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) VAPA_1c10320 ENOG4105E2B Taurine dioxygenase VAPA_1c10330 ENOG4105M0Y VAPA_1c10370 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAPA_1c10400 ENOG4105BZP glycoside hydrolase 15-related VAPA_1c10410 ENOG4108K4C ec 3.1.3.12 VAPA_1c10420 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate VAPA_1c10440 ENOG4107MKT Stringent starvation protein a VAPA_1c10450 ENOG4105KT7 mgtC SapB transporter VAPA_1c10460 ENOG4107SC1 transglycosylase VAPA_1c10470 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase VAPA_1c10480 ENOG4105ETT transcriptional Regulator, LysR family VAPA_1c10540 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VAPA_1c10580 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VAPA_1c10590 ENOG4105EW9 transcriptional regulator AsnC family VAPA_1c10600 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) VAPA_1c10670 ENOG4106NZI LysR family Transcriptional regulator VAPA_1c10680 ENOG4105CSH Transporter VAPA_1c10750 ENOG41082IR Excinuclease ABC C subunit domain protein VAPA_1c10760 ENOG4107R0V Pyruvate dehydrogenase VAPA_1c10770 ENOG4105CPP Dehydrogenase, E1 component VAPA_1c10780 ENOG4107QSN dihydrolipoamide acetyltransferase VAPA_1c10820 ENOG4105EJC lysr family transcriptional regulator VAPA_1c10840 ENOG4105CVE Lytic murein transglycosylase VAPA_1c10900 ENOG4105DDW LysR family Transcriptional regulator VAPA_1c10920 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) VAPA_1c10930 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein VAPA_1c10940 ENOG4105FGE Short-chain dehydrogenase reductase Sdr VAPA_1c10960 ENOG4105C26 Dehydrogenase VAPA_1c10970 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator VAPA_1c10980 ENOG4105DFW ABC transporter VAPA_1c11000 ENOG4108HWW ABC transporter VAPA_1c11010 ENOG4105C2J ABC transporter VAPA_1c11020 ENOG4107R9N ABC transporter VAPA_1c11030 ENOG41062B0 ABC transporter, permease VAPA_1c11060 ENOG4105CBN LysR family transcriptional regulator VAPA_1c11070 ENOG4105CHR reductase VAPA_1c11110 ENOG4107RRY Cyanophycin synthetase VAPA_1c11120 ENOG4107RRY Cyanophycin synthetase VAPA_1c11130 ENOG4105BZ1 (ABC) transporter VAPA_1c11150 ENOG4105EXC Acyl-transferase VAPA_1c11160 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) VAPA_1c11170 ENOG4105CQ0 ABC transporter VAPA_1c11200 ENOG4105DCM major facilitator superfamily VAPA_1c11210 ENOG4105HSS phospholipase C VAPA_1c11220 ENOG4105HSS phospholipase C VAPA_1c11250 ENOG4105D7Q type ii secretion system VAPA_1c11260 ENOG4107QHF type ii secretion system protein e VAPA_1c11270 ENOG4105GVR general secretion pathway protein D VAPA_1c11350 ENOG4108VAU general secretion pathway protein G VAPA_1c11370 ENOG4105C7B Threonine dehydratase VAPA_1c11400 ENOG4108UKZ OsmC family VAPA_1c11410 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) VAPA_1c11420 ENOG4108Z9W Outer membrane porin VAPA_1c11430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAPA_1c11440 ENOG4105CH2 amidohydrolase VAPA_1c11450 ENOG4105DEF Extracellular solute-binding protein, family 5 VAPA_1c11460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_1c11470 ENOG4105C3U ABC transporter VAPA_1c11480 ENOG4108JQ7 (ABC) transporter VAPA_1c11500 ENOG4105VNT transposase (IS4 family) protein VAPA_1c11510 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b VAPA_1c11520 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase VAPA_1c11530 ENOG4105C4Y ABC transporter VAPA_1c11540 ENOG4107RCV ABC transporter, permease VAPA_1c11550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c11580 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VAPA_1c11590 ENOG4107QP8 phosphohexose isomerase VAPA_1c11610 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) VAPA_1c11620 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c11660 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component VAPA_1c11670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c11680 ENOG4105DEI Mannitol dehydrogenase VAPA_1c11690 ENOG4105CHR reductase VAPA_1c11700 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VAPA_1c11720 ENOG4105EQD regulatoR VAPA_1c11730 ENOG4105CMG Carbohydrate kinase VAPA_1c11740 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VAPA_1c11750 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VAPA_1c11760 ENOG4107RZC phospholipase d VAPA_1c11770 ENOG4105E0K tonB-dependent siderophore receptor VAPA_1c11800 ENOG4105CHB tonB-dependent Receptor VAPA_1c11810 ENOG4105CJP fad dependent oxidoreductase VAPA_1c11820 ENOG4105CDA abc transporter atp-binding protein VAPA_1c11840 ENOG4106TNF Periplasmic binding protein VAPA_1c11860 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP VAPA_1c11880 ENOG4105D1S lipid A biosynthesis VAPA_1c11900 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) VAPA_1c11910 ENOG4106RE7 Cytochrome VAPA_1c11920 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) VAPA_1c11940 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) VAPA_1c11950 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) VAPA_1c11960 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) VAPA_1c11970 ENOG4105XQ6 frataxin-like protein VAPA_1c11980 ENOG4108JQC penicillin-binding protein 1A VAPA_1c12030 ENOG4105E4G Type IV pilus VAPA_1c12040 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) VAPA_1c12050 ENOG4105D49 3-dehydroquinate synthase VAPA_1c12060 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein VAPA_1c12130 ENOG4105DHJ ABC, transporter VAPA_1c12140 ENOG4105CY3 ABC transporter, permease VAPA_1c12150 ENOG4107PE3 Mammalian cell entry related domain protein VAPA_1c12190 ENOG4105DA5 (ABC) transporter VAPA_1c12200 ENOG4105E3A (ABC) transporter VAPA_1c12210 ENOG4105VFK BolA family VAPA_1c12220 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) VAPA_1c12230 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) VAPA_1c12260 ENOG4105CIH Imidazole acetol-phosphate transaminase VAPA_1c12270 ENOG4105ECC imidazole-glycerol-phosphate dehydratase VAPA_1c12290 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase VAPA_1c12300 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VAPA_1c12310 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c12320 ENOG4105CK2 sodium dicarboxylate symporter VAPA_1c12340 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) VAPA_1c12350 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase VAPA_1c12360 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase VAPA_1c12380 ENOG4107YU2 histidine triad (hIT) protein VAPA_1c12390 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VAPA_1c12400 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) VAPA_1c12410 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) VAPA_1c12420 ENOG4105C0H protease VAPA_1c12430 ENOG4105CSH Transporter VAPA_1c12440 ENOG4107QNR UPF0135 protein VAPA_1c12450 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) VAPA_1c12460 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) VAPA_1c12510 ENOG4105D3Q Sugar transferase VAPA_1c12560 ENOG4105E3R (LipO)protein VAPA_1c12590 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VAPA_1c12600 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VAPA_1c12610 ENOG4105EIX cytochrome c1 VAPA_1c12620 ENOG4107MKT Stringent starvation protein a VAPA_1c12630 ENOG4105KB2 stringent starvation protein b VAPA_1c12670 ENOG4105CYX Short-chain dehydrogenase reductase Sdr VAPA_1c12680 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) VAPA_1c12700 ENOG4105D60 lipoprotein releasing system transmembrane protein VAPA_1c12710 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VAPA_1c12720 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VAPA_1c12730 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) VAPA_1c12850 ENOG4108MEJ flavin reductase domain protein VAPA_1c12870 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) VAPA_1c12890 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase VAPA_1c12920 ENOG4105DXM phenylacetic acid degradation protein VAPA_1c12930 ENOG4108IV0 ABC, transporter VAPA_1c12970 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VAPA_1c12980 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit VAPA_1c12990 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit VAPA_1c13000 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit VAPA_1c13010 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit VAPA_1c13030 ENOG4108ZJI phenylacetic acid degradation protein VAPA_1c13040 ENOG4108UKI Enoyl-CoA hydratase VAPA_1c13060 ENOG4108IG5 Transcriptional regulator VAPA_1c13070 ENOG4107QVM von Willebrand factor, type A VAPA_1c13090 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VAPA_1c13100 ENOG4105C0H protease VAPA_1c13110 ENOG4105EYA deoxyribonuclease VAPA_1c13140 ENOG4105I7M spermidine synthase VAPA_1c13150 ENOG4107QHF type ii secretion system protein e VAPA_1c13180 ENOG4105DND Transcriptional regulator VAPA_1c13220 ENOG4105CHR reductase VAPA_1c13240 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein VAPA_1c13260 ENOG4105EAM Na Pi-cotransporter VAPA_1c13270 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VAPA_1c13280 ENOG4108IJ6 ABC transporter VAPA_1c13300 ENOG4108I5D sulfate abc transporter VAPA_1c13330 ENOG4105ETE Transcriptional regulator (LacI family VAPA_1c13340 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) VAPA_1c13360 ENOG4105DTN riboflavin biosynthesis protein ribF VAPA_1c13410 ENOG4105X7H acyl-CoA dehydrogenase VAPA_1c13420 ENOG4108V3E phosphoribosylglycinamide formyltransferase VAPA_1c13480 ENOG4105W0E 50S ribosomal protein L33 VAPA_1c13490 ENOG4105KDC 50s ribosomal protein l28 VAPA_1c13500 ENOG4105C3M thioredoxin reductase VAPA_1c13520 ENOG4105CNU cell division protein FtsK VAPA_1c13530 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) VAPA_1c13540 ENOG4105D1H recombination factor protein RarA VAPA_1c13550 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c13560 ENOG4105CF8 branched-chain amino acid ABC transporter, permease VAPA_1c13570 ENOG4105C0Z ABC transporter VAPA_1c13580 ENOG4108IV0 ABC, transporter VAPA_1c13600 ENOG4108EX3 reductase VAPA_1c13690 ENOG4105C6T cysteine synthase VAPA_1c13700 ENOG4105E09 nadh pyrophosphatase VAPA_1c13710 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) VAPA_1c13720 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase VAPA_1c13730 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) VAPA_1c13740 ENOG4105D1Q UPF0246 protein VAPA_1c13760 ENOG4108MUZ hydrolase VAPA_1c13770 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) VAPA_1c13780 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr VAPA_1c13810 ENOG4105CXK mandelate racemase muconate lactonizing VAPA_1c13840 ENOG4108PGP mmge prpd family protein VAPA_1c13850 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c13870 ENOG4105CC9 acyl-Coa dehydrogenase VAPA_1c13890 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c13950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VAPA_1c14010 ENOG4106NZI LysR family Transcriptional regulator VAPA_1c14050 ENOG4105CSH Transporter VAPA_1c14060 ENOG4105DMF Dehydrogenase VAPA_1c14070 ENOG4108PZW LysR family Transcriptional regulator VAPA_1c14110 ENOG4108Q9V regulatoR VAPA_1c14120 ENOG4105I5W Transporter VAPA_1c14150 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) VAPA_1c14160 ENOG4105EMU Dehydrogenase VAPA_1c14170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAPA_1c14180 ENOG4105CIH Imidazole acetol-phosphate transaminase VAPA_1c14210 ENOG4107QRA Extracellular solute-binding protein, family 5 VAPA_1c14240 ENOG4108JQ6 ABC transporter VAPA_1c14260 ENOG4105CH2 amidohydrolase VAPA_1c14270 ENOG4105DJ2 Major Facilitator Superfamily VAPA_1c14280 ENOG4105JXH GntR family transcriptional regulator VAPA_1c14310 ENOG410829K Lysine exporter protein (Lyse ygga) VAPA_1c14350 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) VAPA_1c14390 ENOG4105CZN Potassium uptake protein VAPA_1c14400 ENOG4107ZYR domain protein VAPA_1c14420 ENOG4108UVJ appr-1-p processing domain protein VAPA_1c14530 ENOG4105CH7 arginosuccinase VAPA_1c14540 ENOG4108HRK Histidine kinase VAPA_1c14550 ENOG4108NEV two component transcriptional regulator, LytTR family VAPA_1c14560 ENOG4105DSF transport protein VAPA_1c14610 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c14640 ENOG4105E2V Glycosyltransferase 36 VAPA_1c14660 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) VAPA_1c14670 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) VAPA_1c14710 ENOG4105C03 ribonuclease VAPA_1c14720 ENOG4105EI2 Pseudouridine synthase VAPA_1c14750 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VAPA_1c14760 ENOG4106UW1 Major Facilitator superfamily VAPA_1c14770 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VAPA_1c14780 ENOG4108UHJ MAF-like protein VAPA_1c14790 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein VAPA_1c14800 ENOG4105VGS 50s ribosomal protein l32 VAPA_1c14810 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) VAPA_1c14820 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VAPA_1c14830 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase VAPA_1c14840 ENOG4105CHR reductase VAPA_1c14850 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VAPA_1c14860 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VAPA_1c14910 ENOG4105C0H protease VAPA_1c14920 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) VAPA_1c14930 ENOG4105C3F Signal peptidase i VAPA_1c14950 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) VAPA_1c14960 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) VAPA_1c14970 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) VAPA_1c14980 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) VAPA_1c14990 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) VAPA_1c15000 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) VAPA_1c15010 ENOG4108VKG metal-dependent hydrolase VAPA_1c15020 ENOG4105R8A Heat shock protein VAPA_1c15030 ENOG4105CRK lysyL-tRNA synthetase VAPA_1c15050 ENOG4108VIA integral membrane protein VAPA_1c15060 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) VAPA_1c15070 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) VAPA_1c15080 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) VAPA_1c15090 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase VAPA_1c15100 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) VAPA_1c15120 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VAPA_1c15130 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAPA_1c15140 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAPA_1c15150 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAPA_1c15180 ENOG4105BZN citrate synthase VAPA_1c15190 ENOG41060IS Flavinator of succinate dehydrogenase VAPA_1c15200 ENOG4105E33 succinate dehydrogenase VAPA_1c15210 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VAPA_1c15240 ENOG4105FDP GntR family transcriptional regulator VAPA_1c15250 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) VAPA_1c15260 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) VAPA_1c15290 ENOG4107QIJ Aconitate hydratase 2 VAPA_1c15300 ENOG4107QPN acyl-Coa dehydrogenase VAPA_1c15330 ENOG4107QM5 aconitate hydratase VAPA_1c15360 ENOG4105CE1 Ferrous iron transport protein b VAPA_1c15380 ENOG4105MSY salicylate hydroxylase VAPA_1c15400 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) VAPA_1c15420 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) VAPA_1c15440 ENOG4105DBV ornithine carbamoyltransferase VAPA_1c15450 ENOG4105C8Y Acetylornithine aminotransferase VAPA_1c15470 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) VAPA_1c15480 ENOG4105CJR Integral membrane protein (MviN VAPA_1c15510 ENOG4105GRZ Ycii-related protein VAPA_1c15520 ENOG4105GRZ Ycii-related protein VAPA_1c15530 ENOG4105CHP RNA polymerase VAPA_1c15540 ENOG4105E7U AraC family transcriptional regulator VAPA_1c15570 ENOG4105CXB phosphoribosylaminoimidazole synthetase VAPA_1c15580 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) VAPA_1c15590 ENOG4105DJ0 Poly(A) Polymerase VAPA_1c15600 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VAPA_1c15610 ENOG4107GRR phosphate transport regulator VAPA_1c15620 ENOG4107QXV Phosphate transporter VAPA_1c15650 ENOG4105K5M 30s ribosomal protein S16 VAPA_1c15660 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) VAPA_1c15670 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) VAPA_1c15680 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) VAPA_1c15690 ENOG4105P8F nudix hydrolase VAPA_1c15700 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) VAPA_1c15710 ENOG4105E45 Histidinol-phosphate aminotransferase VAPA_1c15720 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VAPA_1c15730 ENOG41090A4 Pterin carbinolamine dehydratase VAPA_1c15740 ENOG4105D0M Protease HtpX homolog VAPA_1c15750 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) VAPA_1c15760 ENOG4105C1J atp-dependent rna helicase VAPA_1c15770 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase VAPA_1c15780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAPA_1c15790 ENOG4105DWV Homoserine O-trans-acetylase VAPA_1c15800 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family VAPA_1c15850 ENOG4105FUY alpha subunit VAPA_1c15870 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c15900 ENOG4106IPI cyclase, family VAPA_1c15910 ENOG4105CHR reductase VAPA_1c15920 ENOG4105CP9 extracellular ligand-binding receptor VAPA_1c15970 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c15980 ENOG4105C0Z ABC transporter VAPA_1c15990 ENOG4108IV0 ABC, transporter VAPA_1c16000 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c16010 ENOG4108R85 Short chain dehydrogenase VAPA_1c16260 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c16300 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) VAPA_1c16320 ENOG41090JD Blue (Type 1) copper domain protein VAPA_1c16330 ENOG4105C4R Atp-dependent dna helicase VAPA_1c16350 ENOG4105CUV Homoserine Kinase VAPA_1c16370 ENOG4105C2M dna polymerase I VAPA_1c16400 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_1c16410 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c16430 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) VAPA_1c16510 ENOG4108J59 Extracellular solute-binding protein, family 5 VAPA_1c16530 ENOG4105FC8 fad dependent oxidoreductase VAPA_1c16560 ENOG4108NST exported protein VAPA_1c16590 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VAPA_1c16610 ENOG4105KHC sulfurtransferase VAPA_1c16640 ENOG41086K9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VAPA_1c16660 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VAPA_1c16670 ENOG4105CH5 extracellular solute-binding protein, family 7 VAPA_1c16680 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c16700 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process VAPA_1c16710 ENOG41079KZ Major Facilitator Superfamily VAPA_1c16720 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family VAPA_1c16730 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VAPA_1c16740 ENOG4105EVZ LysR family transcriptional regulator VAPA_1c16750 ENOG4108K85 Transcriptional regulator VAPA_1c16770 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c16790 ENOG4105C0Z ABC transporter VAPA_1c16800 ENOG4108IV0 ABC, transporter VAPA_1c16810 ENOG4105CE7 Amidase, hydantoinase carbamoylase family VAPA_1c16840 ENOG4108JJB ABC transporter VAPA_1c16940 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family VAPA_1c16950 ENOG4105KJM monovalent cation h antiporter subunit g VAPA_1c16960 ENOG4105W4C monovalent cation H antiporter subunit F VAPA_1c16980 ENOG4107R4Z monovalent cation h antiporter subunit d VAPA_1c16990 ENOG4108ZE9 Monovalent cation H antiporter subunit C VAPA_1c17000 ENOG4105D65 subunit l VAPA_1c17010 ENOG4107Z6W Protein CrcB homolog VAPA_1c17020 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c17060 ENOG4105CFV Tetratricopeptide repeat protein VAPA_1c17090 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) VAPA_1c17100 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase VAPA_1c17110 ENOG4105EVN Prephenate dehydrogenase VAPA_1c17130 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) VAPA_1c17150 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAPA_1c17160 ENOG4105UYK outer membrane protein a VAPA_1c17170 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VAPA_1c17180 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VAPA_1c17230 ENOG4105KUS lysozyme VAPA_1c17290 ENOG4107MBT Plasmid stabilisation system protein VAPA_1c17300 ENOG4106R49 Methyltransferase VAPA_1c17320 ENOG4105I08 Pseudouridine synthase VAPA_1c17370 ENOG4107TH8 cina domain protein VAPA_1c17380 ENOG4105C5F glutamine synthetase VAPA_1c17400 ENOG4105CUX Signal transduction histidine kinase VAPA_1c17410 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAPA_1c17430 ENOG4105CGK Exodeoxyribonuclease III VAPA_1c17470 ENOG4105EHU Circadian clock protein KaiC VAPA_1c17480 ENOG4105C08 Histidine kinase VAPA_1c17490 ENOG4107UXM Membrane VAPA_1c17500 ENOG4105DQE DNA ligase VAPA_1c17530 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) VAPA_1c17570 ENOG4105CQB FAD linked oxidase domain protein VAPA_1c17590 ENOG4107S2Z UPF0761 membrane protein VAPA_1c17610 ENOG4105K63 Thioredoxin VAPA_1c17630 ENOG4105EMY transcriptional regulator VAPA_1c17660 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) VAPA_1c17710 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) VAPA_1c17720 ENOG4106NZI LysR family Transcriptional regulator VAPA_1c17780 ENOG4107QVI Methyltransferase, type 11 VAPA_1c17820 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family VAPA_1c17830 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) VAPA_1c17850 ENOG4105HP8 regulator of competence-specific genes VAPA_1c17870 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase VAPA_1c17890 ENOG4105C4W S-formylglutathione hydrolase VAPA_1c17910 ENOG4107QPD alcohol dehydrogenase VAPA_1c17950 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) VAPA_1c17960 ENOG4105ED1 spovr family VAPA_1c17970 ENOG4106AKX UPF0229 protein VAPA_1c17980 ENOG4105CYN Serine protein kinase VAPA_1c18000 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VAPA_1c18010 ENOG4105CFG Acts as a chaperone (By similarity) VAPA_1c18020 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ VAPA_1c18030 ENOG4108V1T peptidylprolyl cis-trans isomerase VAPA_1c18050 ENOG4105DJ4 phosphatidylserine decarboxylase VAPA_1c18070 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) VAPA_1c18080 ENOG4105CHR reductase VAPA_1c18090 ENOG4105CTX dehydratase VAPA_1c18100 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) VAPA_1c18110 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c18130 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_1c18140 ENOG4105E9Z Nad-dependent epimerase dehydratase VAPA_1c18150 ENOG4107YCY Transcriptional regulator VAPA_1c18170 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase VAPA_1c18210 ENOG4105C26 Dehydrogenase VAPA_1c18220 ENOG4105E90 ABC transporter VAPA_1c18250 ENOG4107QWP ABC-2 type transporter VAPA_1c18260 ENOG4107QWP ABC-2 type transporter VAPA_1c18270 ENOG4105CJ1 ABC, transporter VAPA_1c18280 ENOG4105D0S secretion protein (HlyD VAPA_1c18300 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) VAPA_1c18330 ENOG4108WYP Transcriptional regulator VAPA_1c18370 ENOG4105C0Z ABC transporter VAPA_1c18380 ENOG4108IV0 ABC, transporter VAPA_1c18420 ENOG4108W5M transcriptional regulator VAPA_1c18430 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase VAPA_1c18440 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c18480 ENOG4105C2C drug resistance transporter, Bcr CflA VAPA_1c18490 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAPA_1c18500 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) VAPA_1c18510 ENOG4107S2Z UPF0761 membrane protein VAPA_1c18530 ENOG4108WFY phasin family VAPA_1c18540 ENOG4105DGU Histone deacetylase VAPA_1c18570 ENOG4105VDW Csbd family VAPA_1c18580 ENOG4107RH7 Nicotinate phosphoribosyltransferase VAPA_1c18600 ENOG4105C5I Dehydrogenase VAPA_1c18610 ENOG4107QSV RmuC domain protein VAPA_1c18640 ENOG4105EWT decarboxylase family VAPA_1c18650 ENOG4105E39 Enoyl-CoA hydratase VAPA_1c18660 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VAPA_1c18680 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) VAPA_1c18690 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase VAPA_1c18710 ENOG4105EJC lysr family transcriptional regulator VAPA_1c18720 ENOG4105EBM Alpha Beta Hydrolase Fold protein VAPA_1c18730 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAPA_1c18760 ENOG4107TF3 peptidylprolyl cis-trans isomerase VAPA_1c18800 ENOG4108V1U phospholipid-binding protein VAPA_1c18840 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) VAPA_1c18850 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) VAPA_1c18860 ENOG4108K5P (LipO)protein VAPA_1c18870 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAPA_1c18880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VAPA_1c18890 ENOG4108MN8 Membrane VAPA_1c18900 ENOG4108ZJF Glcg protein VAPA_1c18920 ENOG4105M8F Biopolymer transport protein exbD tolR VAPA_1c18970 ENOG4108UQY Iron-storage protein VAPA_1c18980 ENOG4105D3R alkyl hydroperoxide reductase VAPA_1c18990 ENOG4108JU3 Alkyl hydroperoxide reductase VAPA_1c19000 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) VAPA_1c19010 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) VAPA_1c19030 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) VAPA_1c19050 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) VAPA_1c19060 ENOG4105K9Q Binds to the 23S rRNA (By similarity) VAPA_1c19070 ENOG4105CDU Replicative dna helicase VAPA_1c19100 ENOG4105M5P UPF0310 protein VAPA_1c19120 ENOG4108IAB Phoh family VAPA_1c19130 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VAPA_1c19150 ENOG4105CHM Aminotransferase VAPA_1c19160 ENOG4105D6E homoserine dehydrogenase VAPA_1c19170 ENOG4105D98 threonine synthase VAPA_1c19180 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b VAPA_1c19190 ENOG4105CVM Molybdenum cofactor synthesis domain protein VAPA_1c19200 ENOG4105M00 molybdopterin converting factor, subunit 1 VAPA_1c19210 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VAPA_1c19220 ENOG4108ZAF Molybdopterin VAPA_1c19240 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAPA_1c19260 ENOG4108IQE Amp-dependent synthetase and ligase VAPA_1c19270 ENOG4108IV0 ABC, transporter VAPA_1c19310 ENOG4105C0Z ABC transporter VAPA_1c19330 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c19340 ENOG4108YZN class I peptide chain release factor VAPA_1c19370 ENOG4105HEI LysR family (Transcriptional regulator VAPA_1c19400 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VAPA_1c19410 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VAPA_1c19470 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) VAPA_1c19480 ENOG4105T0Z Conserved Protein VAPA_1c19540 ENOG4107XKF NMT1 THI5 Like Domain Protein VAPA_1c19550 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component VAPA_1c19570 ENOG4108W9H Tetr family transcriptional regulator VAPA_1c19640 ENOG4108I9X Isocitrate lyase VAPA_1c19650 ENOG4105C22 threonyL-tRNA synthetase VAPA_1c19660 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) VAPA_1c19670 ENOG4105VJV 50s ribosomal protein L35 VAPA_1c19680 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) VAPA_1c19690 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) VAPA_1c19700 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) VAPA_1c19710 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VAPA_1c19810 ENOG4105KK6 nuclease VAPA_1c19850 ENOG4105DFP Integrase VAPA_1c19870 ENOG41085FC arsR family transcriptional regulator VAPA_1c19910 ENOG4108UXE Protein tyrosine phosphatase VAPA_1c19940 ENOG4105CAU Arsenical resistance protein, ArsH VAPA_1c19960 ENOG4105H3G oxidoreductase VAPA_1c19970 ENOG4105E0F Histidine kinase VAPA_1c19980 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAPA_1c20010 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VAPA_1c20080 ENOG4105PGM cation diffusion facilitator family transporter VAPA_1c20110 ENOG4107S21 permease VAPA_1c20150 ENOG41073TP transcriptional regulator VAPA_1c20160 ENOG4105VU5 Resolvase domain-containing protein VAPA_1c20180 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAPA_1c20200 ENOG4108Z9W Outer membrane porin VAPA_1c20210 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c20220 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein VAPA_1c20260 ENOG4105E2B Taurine dioxygenase VAPA_1c20280 ENOG4108UQN AraC family transcriptional regulator VAPA_1c20290 ENOG4108Z9W Outer membrane porin VAPA_1c20300 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein VAPA_1c20320 ENOG4105E2B Taurine dioxygenase VAPA_1c20340 ENOG4108ZX5 transcriptional regulator VAPA_1c20450 ENOG4108UKI Enoyl-CoA hydratase VAPA_1c20460 ENOG4105CD5 CoA-binding domain protein VAPA_1c20470 ENOG4108PGP mmge prpd family protein VAPA_1c20480 ENOG41061TZ Short-chain dehydrogenase reductase Sdr VAPA_1c20510 ENOG4108YIQ Alpha beta hydrolase VAPA_1c20530 ENOG4105JQN Transcriptional regulator VAPA_1c20540 ENOG4105CHJ isochorismatase hydrolase VAPA_1c20620 ENOG4105D3Q Sugar transferase VAPA_1c20680 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VAPA_1c20690 ENOG4105C2X Arabinose 5-phosphate isomerase VAPA_1c20700 ENOG4105CMR udp-glucose 4-epimerase VAPA_1c20730 ENOG4105E3R (LipO)protein VAPA_1c20760 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VAPA_1c20780 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate VAPA_1c20800 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c20810 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_1c20820 ENOG4105ETE Transcriptional regulator (LacI family VAPA_1c20840 ENOG4105C26 Dehydrogenase VAPA_1c20850 ENOG4105CTX dehydratase VAPA_1c20860 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c20900 ENOG4105CAU Arsenical resistance protein, ArsH VAPA_1c20930 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase VAPA_1c20940 ENOG4107WAU Protein tyrosine phosphatase VAPA_1c20960 ENOG4105D6J arsenicaL-resistance protein VAPA_1c20990 ENOG4105BZU Histidine kinase VAPA_1c21000 ENOG4107QHF type ii secretion system protein e VAPA_1c21010 ENOG4105BZU Histidine kinase VAPA_1c21090 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) VAPA_1c21100 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) VAPA_1c21110 ENOG4105CG3 alpha amylase, catalytic region VAPA_1c21140 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) VAPA_1c21150 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) VAPA_1c21260 ENOG4108QG2 Membrane VAPA_1c21280 ENOG41080XQ Signal transduction protein with cbs domains VAPA_1c21290 ENOG4105GTG Isochorismatase VAPA_1c21350 ENOG4107RZC phospholipase d VAPA_1c21360 ENOG4108K5P (LipO)protein VAPA_1c21370 ENOG4108RH0 Crea protein VAPA_1c21380 ENOG4105E09 nadh pyrophosphatase VAPA_1c21410 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase VAPA_1c21430 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class VAPA_1c21440 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c21450 ENOG4107653 Transcriptional regulator VAPA_1c21470 ENOG4108M9J MaoC like domain protein VAPA_1c21520 ENOG4107TH8 cina domain protein VAPA_1c21530 ENOG4105CHR reductase VAPA_1c21540 ENOG4105CKD glutathione-regulated potassium-efflux system protein VAPA_1c21570 ENOG4105D6E homoserine dehydrogenase VAPA_1c21670 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF VAPA_1c21690 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c21710 ENOG4108JJ6 Type I secretion system ATPase VAPA_1c21720 ENOG4108JJ6 Type I secretion system ATPase VAPA_1c21750 ENOG4105EW9 transcriptional regulator AsnC family VAPA_1c21760 ENOG4105C7K acetolactate synthase VAPA_1c21770 ENOG4108JU7 Transcriptional regulator VAPA_1c21810 ENOG4105K56 Transcriptional regulator VAPA_1c21850 ENOG4105E5Q amino acid AbC transporter VAPA_1c21860 ENOG4105E89 ABC transporter VAPA_1c21880 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) VAPA_1c21890 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c21910 ENOG4105ETE Transcriptional regulator (LacI family VAPA_1c21930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VAPA_1c21940 ENOG4105CDA abc transporter atp-binding protein VAPA_1c21970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VAPA_1c21980 ENOG4105CHR reductase VAPA_1c21990 ENOG4105C5I Dehydrogenase VAPA_1c22000 ENOG4105CPQ Dehydrogenase VAPA_1c22010 ENOG4105DIQ Transcriptional regulator VAPA_1c22060 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process VAPA_1c22110 ENOG4108ZX5 transcriptional regulator VAPA_1c22130 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c22160 ENOG4107RYR Transcriptional regulator, Crp Fnr family VAPA_1c22180 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VAPA_1c22220 ENOG4105EMU Dehydrogenase VAPA_1c22230 ENOG4105HEI LysR family (Transcriptional regulator VAPA_1c22240 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) VAPA_1c22260 ENOG4108JUA Transcriptional regulator VAPA_1c22280 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) VAPA_1c22320 ENOG4107QZF nitrite reductase NADPH large subunit VAPA_1c22420 ENOG4108R85 Short chain dehydrogenase VAPA_1c22430 ENOG4105CIH Imidazole acetol-phosphate transaminase VAPA_1c22450 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c22460 ENOG4105EAD ABC transporter VAPA_1c22470 ENOG4105DRP amino acid AbC transporter VAPA_1c22480 ENOG4105CDA abc transporter atp-binding protein VAPA_1c22520 ENOG4105C26 Dehydrogenase VAPA_1c22530 ENOG4105MP9 class II Aldolase VAPA_1c22560 ENOG41061TZ Short-chain dehydrogenase reductase Sdr VAPA_1c22570 ENOG4105FUY alpha subunit VAPA_1c22620 ENOG4105C7K acetolactate synthase VAPA_1c22640 ENOG4105ERH Fumarylacetoacetate hydrolase VAPA_1c22660 ENOG4105C26 Dehydrogenase VAPA_1c22670 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase VAPA_1c22720 ENOG4105R0I Feruloyl esterase VAPA_1c22730 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VAPA_1c22760 ENOG4105F2I Transposase VAPA_1c22910 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VAPA_1c22940 ENOG4105DRR Transcriptional regulator, GntR family VAPA_1c22970 ENOG4105DJT lAO AO transport system ATPase VAPA_1c22980 ENOG4107QX3 carboxylase VAPA_1c22990 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VAPA_1c23000 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) VAPA_1c23050 ENOG4105FDR Membrane VAPA_1c23070 ENOG4108R3D Electron transport complex VAPA_1c23090 ENOG4105CGF Aromatic amino acid aminotransferase VAPA_1c23100 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) VAPA_1c23110 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family VAPA_1c23120 ENOG4105C3J Cysteine desulfurase VAPA_1c23130 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins VAPA_1c23160 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VAPA_1c23170 ENOG4108ZIT Ferredoxin, 2FE-2S VAPA_1c23180 ENOG4107RZZ dna polymerase iii epsilon subunit VAPA_1c23300 ENOG4105D5U fad dependent oxidoreductase VAPA_1c23330 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) VAPA_1c23340 ENOG4105E66 phosphoriboisomerase A VAPA_1c23360 ENOG4105DGW oligopeptidase A VAPA_1c23370 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) VAPA_1c23380 ENOG4108ZXC Two component transcriptional regulator, luxr family VAPA_1c23390 ENOG4105BZU Histidine kinase VAPA_1c23400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) VAPA_1c23410 ENOG4107QSN dihydrolipoamide acetyltransferase VAPA_1c23420 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) VAPA_1c23430 ENOG4107QN2 dihydrolipoyl dehydrogenase VAPA_1c23440 ENOG4105K4H Nlp p60 protein VAPA_1c23450 ENOG4105D8V Glucose sorbosone dehydrogenase VAPA_1c23500 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VAPA_1c23510 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 VAPA_1c23520 ENOG4105C7S Dehydrogenase VAPA_1c23530 ENOG4107QN2 dihydrolipoyl dehydrogenase VAPA_1c23540 ENOG4105D6Z AFG1 family ATPase VAPA_1c23580 ENOG4105DVT helicase VAPA_1c23600 ENOG4105C34 Pseudouridine synthase VAPA_1c23610 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) VAPA_1c23620 ENOG4105FE9 pseudouridine synthase VAPA_1c23630 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) VAPA_1c23640 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs VAPA_1c23670 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) VAPA_1c23680 ENOG4105CUT histidyl-tRNA synthetase VAPA_1c23710 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) VAPA_1c23720 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) VAPA_1c23730 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) VAPA_1c23740 ENOG4107QJR hflk protein VAPA_1c23750 ENOG4105EPW hflc protein VAPA_1c23770 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) VAPA_1c23780 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis VAPA_1c23830 ENOG4105C28 cystathionine VAPA_1c23850 ENOG4108UJV acyl-CoA thioesterase i VAPA_1c23860 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VAPA_1c23880 ENOG4105C2N RNA methyltransferase TrmH family group 3 VAPA_1c23910 ENOG4108Z7F N-acetyltransferase VAPA_1c23920 ENOG4105CPC Aldo Keto reductase VAPA_1c23930 ENOG4105CAH Chromate VAPA_1c23950 ENOG4107S2Z UPF0761 membrane protein VAPA_1c24040 ENOG4105CCT upf0313 protein VAPA_1c24090 ENOG4105K6S Short-chain dehydrogenase reductase Sdr VAPA_1c24130 ENOG4106YT9 Enoyl-CoA hydratase VAPA_1c24210 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component VAPA_1c24220 ENOG4105MP9 class II Aldolase VAPA_1c24240 ENOG4105JXH GntR family transcriptional regulator VAPA_1c24250 ENOG41061TZ Short-chain dehydrogenase reductase Sdr VAPA_1c24260 ENOG4105CIH Imidazole acetol-phosphate transaminase VAPA_1c24280 ENOG4105CE7 Amidase, hydantoinase carbamoylase family VAPA_1c24350 ENOG4105VNT transposase (IS4 family) protein VAPA_1c24430 ENOG4105CYM Glutathione S-transferase VAPA_1c24440 ENOG4105C3M thioredoxin reductase VAPA_1c24500 ENOG4105C9X ppx gppa phosphatase VAPA_1c24510 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) VAPA_1c24520 ENOG4105C8U phosphate abc transporter VAPA_1c24530 ENOG4105E2Z phosphate ABC transporter (Permease VAPA_1c24540 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c24570 ENOG4105BZU Histidine kinase VAPA_1c24580 ENOG4107QI1 Mate efflux family protein VAPA_1c24600 ENOG4105NRA 50s ribosomal protein l31 type b VAPA_1c24610 ENOG4105D9R oxidoreductase VAPA_1c24620 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) VAPA_1c24630 ENOG4105K63 Thioredoxin VAPA_1c24650 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation VAPA_1c24690 ENOG4107QMP dna polymerase iii subunits gamma and tau VAPA_1c24700 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) VAPA_1c24710 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) VAPA_1c24730 ENOG4105D2X ABC transporter substrate-binding protein VAPA_1c24750 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VAPA_1c24760 ENOG4105E9H Lytic Murein transglycosylase VAPA_1c24770 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) VAPA_1c24780 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) VAPA_1c24790 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VAPA_1c24800 ENOG4105CVM Molybdenum cofactor synthesis domain protein VAPA_1c24810 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) VAPA_1c24820 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VAPA_1c24830 ENOG4105C26 Dehydrogenase VAPA_1c24850 ENOG4107RZC phospholipase d VAPA_1c24970 ENOG4105F0N pyrophosphate phospho-hydrolase VAPA_1c24990 ENOG4105C4K Nad synthetase VAPA_1c25000 ENOG4108YZA Nitrogen regulatory protein pii VAPA_1c25010 ENOG4108URH decarboxylase VAPA_1c25020 ENOG41080IJ Diacylglycerol kinase VAPA_1c25070 ENOG4105C7K acetolactate synthase VAPA_1c25080 ENOG4108ZP8 Acetolactate synthase small subunit VAPA_1c25100 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase VAPA_1c25110 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase VAPA_1c25120 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) VAPA_1c25130 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) VAPA_1c25140 ENOG41061WM D-Alanyl-D-Alanine VAPA_1c25150 ENOG41069M3 Transcriptional regulator VAPA_1c25160 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate VAPA_1c25170 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) VAPA_1c25220 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase VAPA_1c25230 ENOG4107HP6 Transcriptional regulator VAPA_1c25240 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_1c25250 ENOG4105DHQ Histidine kinase VAPA_1c25260 ENOG4105C0H protease VAPA_1c25340 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) VAPA_1c25350 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) VAPA_1c25420 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase VAPA_1c25440 ENOG4105CAY ferredoxin--nadp reductase VAPA_1c25450 ENOG4108Z4U Ferredoxin VAPA_1c25460 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) VAPA_1c25530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_1c25540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAPA_1c25560 ENOG4108JQ6 ABC transporter VAPA_1c25570 ENOG4105D44 asparaginase VAPA_1c25620 ENOG4105CPC Aldo Keto reductase VAPA_1c25630 ENOG4108PZW LysR family Transcriptional regulator VAPA_1c25650 ENOG4107R1Y fructose-bisphosphate aldolase VAPA_1c25660 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VAPA_1c25700 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) VAPA_1c25710 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) VAPA_1c25720 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein VAPA_1c25730 ENOG4108UZX fmn reductase VAPA_1c25750 ENOG4105GVF (ABC) transporter VAPA_1c25770 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) VAPA_1c25780 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VAPA_1c25790 ENOG4105E2Y ABC, transporter VAPA_1c25820 ENOG4105D7W serine acetyltransferase VAPA_1c25850 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VAPA_1c25870 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) VAPA_1c25880 ENOG4105EXG Transcriptional regulator VAPA_1c25890 ENOG4105D3R alkyl hydroperoxide reductase VAPA_1c25910 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein VAPA_1c25920 ENOG4108I5D sulfate abc transporter VAPA_1c25930 ENOG4105ECW sulfate abc transporter VAPA_1c25940 ENOG4108IJ6 ABC transporter VAPA_1c25950 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) VAPA_1c26000 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) VAPA_1c26020 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) VAPA_1c26040 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VAPA_1c26060 ENOG4107QXX ABC transporter VAPA_1c26070 ENOG4105EZ7 amino acid ABC transporter VAPA_1c26080 ENOG4105DRP amino acid AbC transporter VAPA_1c26110 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) VAPA_1c26120 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) VAPA_1c26130 ENOG4108ETH Formylglycinamide ribotide synthetase VAPA_1c26140 ENOG4107TF3 peptidylprolyl cis-trans isomerase VAPA_1c26160 ENOG4107835 probably involved in intracellular septation (By similarity) VAPA_1c26170 ENOG4105E0X reductase VAPA_1c26180 ENOG4105CNG UPF0061 protein VAPA_1c26200 ENOG4105EBR Carboxylesterase VAPA_1c26210 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c26240 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c26260 ENOG4105C0Z ABC transporter VAPA_1c26280 ENOG4108IV0 ABC, transporter VAPA_1c26290 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAPA_1c26300 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VAPA_1c26310 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c26320 ENOG4105CSU acyl-Coa dehydrogenase VAPA_1c26350 ENOG4105CHR reductase VAPA_1c26370 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein VAPA_1c26380 ENOG4105CSU acyl-Coa dehydrogenase VAPA_1c26420 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) VAPA_1c26430 ENOG4105CPC Aldo Keto reductase VAPA_1c26440 ENOG4105F27 Major Facilitator VAPA_1c26450 ENOG4105HEI LysR family (Transcriptional regulator VAPA_1c26500 ENOG4105CQB FAD linked oxidase domain protein VAPA_1c26530 ENOG4105ETT transcriptional Regulator, LysR family VAPA_1c26570 ENOG4105D0M Protease HtpX homolog VAPA_1c26580 ENOG4105C2C drug resistance transporter, Bcr CflA VAPA_1c26590 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAPA_1c26600 ENOG4105H2K paraquat-inducible protein a VAPA_1c26610 ENOG4105F1S paraquat-inducible protein a VAPA_1c26620 ENOG4105DY2 Paraquat-inducible protein b VAPA_1c26680 ENOG4107QJQ Mate efflux family protein VAPA_1c26730 ENOG4105DEI Mannitol dehydrogenase VAPA_1c26740 ENOG4105CXK mandelate racemase muconate lactonizing VAPA_1c26760 ENOG4105E5Q amino acid AbC transporter VAPA_1c26770 ENOG4105E5Q amino acid AbC transporter VAPA_1c26780 ENOG4105CPQ Dehydrogenase VAPA_1c26810 ENOG4105C6F GntR Family Transcriptional Regulator VAPA_1c26820 ENOG4105BZM domain protein VAPA_1c26900 ENOG4105CS6 Rhs element vgr protein VAPA_1c26910 ENOG4105C0A alcohol dehydrogenase VAPA_1c26950 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) VAPA_1c26960 ENOG4105HHA aminodeoxychorismate lyase VAPA_1c26970 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) VAPA_1c26980 ENOG4107QRG dna polymerase iii VAPA_1c27000 ENOG4105F8V Hydrolase, tatD family VAPA_1c27050 ENOG4105WKW Pfam:DUF1458 VAPA_1c27060 ENOG4108IFG nitrite reductase, (NAD(P)H) VAPA_1c27080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VAPA_1c27100 ENOG4105D9P serine threonine protein kinase VAPA_1c27130 ENOG4106855 Competence protein VAPA_1c27170 ENOG4105CWU Biogenesis protein VAPA_1c27220 ENOG41080TK Universal stress protein VAPA_1c27260 ENOG4107QRI Phosphoketolase VAPA_1c27280 ENOG4105D4P Coproporphyrinogen iii oxidase VAPA_1c27350 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i VAPA_1c27370 ENOG4105C59 p-type ATPase VAPA_1c27390 ENOG4105CF7 AraC family transcriptional regulator VAPA_1c27400 ENOG4105CPC Aldo Keto reductase VAPA_1c27410 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VAPA_1c27420 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VAPA_1c27470 ENOG4105DVT helicase VAPA_1c27480 ENOG4105BZU Histidine kinase VAPA_1c27490 ENOG4105BZU Histidine kinase VAPA_1c27500 ENOG4107Z5C methylesterase VAPA_1c27560 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VAPA_1c27570 ENOG4108Z6B deaminase VAPA_1c27620 ENOG4108ZXC Two component transcriptional regulator, luxr family VAPA_1c27630 ENOG4105BZU Histidine kinase VAPA_1c27700 ENOG4105CKI cobalamin synthesis protein VAPA_1c27710 ENOG4105DSE periplasmic solute binding protein VAPA_1c27720 ENOG4105CC5 ABC transporter VAPA_1c27730 ENOG4105DIK (ABC) transporter VAPA_1c27780 ENOG4105KME endoribonuclease L-psp VAPA_1c27800 ENOG4106NZI LysR family Transcriptional regulator VAPA_1c27820 ENOG4105CWC Acetylornithine deacetylase VAPA_1c27840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VAPA_1c27870 ENOG4105CYW agmatinase VAPA_1c27880 ENOG4105EXG Transcriptional regulator VAPA_1c27900 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr VAPA_1c27940 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VAPA_1c27970 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VAPA_1c27990 ENOG4105VDB UPF0125 protein VAPA_1c28000 ENOG4108Z1B Cyclase dehydrase VAPA_1c28010 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) VAPA_1c28080 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) VAPA_1c28090 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) VAPA_1c28110 ENOG4105CHV Transcription elongation factor NusA VAPA_1c28120 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) VAPA_1c28130 ENOG4105CBP Major Facilitator VAPA_1c28140 ENOG4108JQ5 ABC transporter VAPA_1c28150 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component VAPA_1c28160 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component VAPA_1c28170 ENOG4105E43 Extracellular solute-binding protein, family 5 VAPA_1c28180 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH VAPA_1c28200 ENOG4105CXN decarboxylase VAPA_1c28260 ENOG4105CP9 extracellular ligand-binding receptor VAPA_1c28290 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VAPA_1c28330 ENOG4107R11 Transcriptional regulator VAPA_1c28340 ENOG4105CHM Aminotransferase VAPA_1c28360 ENOG4105CQ7 ATP-dependent helicase VAPA_1c28380 ENOG4108EKC n-acetylglutamate synthase VAPA_1c28390 ENOG410829K Lysine exporter protein (Lyse ygga) VAPA_1c28430 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) VAPA_1c28440 ENOG4105CZX twitching motility protein VAPA_1c28450 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VAPA_1c28460 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) VAPA_1c28470 ENOG4105C5H ABC transporter VAPA_1c28510 ENOG4105CUZ uba thif-type nad fad binding protein VAPA_1c28530 ENOG4105KCK Peptidoglycan-associated lipoprotein VAPA_1c28540 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) VAPA_1c28550 ENOG4105BZ1 (ABC) transporter VAPA_1c28560 ENOG4105C03 ribonuclease VAPA_1c28570 ENOG4108Z03 MAF-like protein VAPA_1c28580 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) VAPA_1c28590 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) VAPA_1c28600 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) VAPA_1c28610 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) VAPA_1c28620 ENOG4105C12 Phosphoribosylglycinamide synthetase VAPA_1c28630 ENOG4105CDY transcriptional regulatory protein VAPA_1c28640 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VAPA_1c28680 ENOG4105CHR reductase VAPA_1c28750 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VAPA_1c28780 ENOG4105D7A ATP-binding protein VAPA_1c28800 ENOG4105NCT RNA Polymerase VAPA_1c28850 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) VAPA_1c28860 ENOG4107TFB basic membrane VAPA_1c28870 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) VAPA_1c28880 ENOG4108JQ9 ABC transporter VAPA_1c28890 ENOG4105UIB (ABC) transporter VAPA_1c28920 ENOG4105DZC cytosine deaminase VAPA_1c28930 ENOG4105E0F Histidine kinase VAPA_1c28940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAPA_1c28990 ENOG4105CJB Exodeoxyribonuclease I VAPA_1c29000 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) VAPA_1c29010 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAPA_1c29020 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) VAPA_1c29070 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VAPA_1c29080 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VAPA_1c29100 ENOG4108ZZF transport protein (ExbD) VAPA_1c29110 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) VAPA_1c29120 ENOG4105W49 UPF0434 protein VAPA_1c29130 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) VAPA_1c29140 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) VAPA_1c29150 ENOG4105HDK L-asparaginase VAPA_1c29160 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) VAPA_1c29180 ENOG4108M3J Dehydrogenase VAPA_1c29190 ENOG4105F27 Major Facilitator VAPA_1c29200 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAPA_1c29210 ENOG4108UKI Enoyl-CoA hydratase VAPA_1c29220 ENOG4105IJJ transcriptional regulator, crp fnr family VAPA_1c29240 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c29260 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VAPA_1c29270 ENOG4105EEI dihydropteroate synthase VAPA_1c29280 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VAPA_1c29290 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) VAPA_1c29300 ENOG4105HBR Rna-binding protein VAPA_1c29330 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) VAPA_1c29350 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain VAPA_1c29390 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VAPA_1c29400 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAPA_1c29410 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAPA_1c29420 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VAPA_1c29430 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAPA_1c29450 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane VAPA_1c29460 ENOG4105DZP Membrane-associated zinc metalloprotease VAPA_1c29470 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) VAPA_1c29480 ENOG4105KNE Phosphatidate cytidylyltransferase VAPA_1c29500 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) VAPA_1c29510 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) VAPA_1c29520 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) VAPA_1c29530 ENOG4105CE9 30S ribosomal protein S2 VAPA_1c29550 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_1c29560 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) VAPA_1c29570 ENOG41061TZ Short-chain dehydrogenase reductase Sdr VAPA_1c29580 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VAPA_1c29630 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) VAPA_1c29640 ENOG4108NVM synthesis repressor PhaR VAPA_1c29670 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VAPA_1c29690 ENOG4105DTD Dehydrogenase VAPA_1c29720 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAPA_1c29730 ENOG4105E0F Histidine kinase VAPA_1c29740 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) VAPA_1c29750 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) VAPA_1c29760 ENOG4108JA2 transcriptioN-repair coupling factor VAPA_1c29770 ENOG4105EAC phosphoserine phosphatase VAPA_1c29810 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAPA_1c29820 ENOG4105CSM endonuclease III VAPA_1c29830 ENOG4105CHR reductase VAPA_1c29860 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) VAPA_1c29870 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VAPA_1c29880 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VAPA_1c29890 ENOG4105ETP RND efflux system, outer membrane lipoprotein VAPA_1c29970 ENOG4105CIH Imidazole acetol-phosphate transaminase VAPA_1c29980 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) VAPA_1c29990 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase VAPA_1c30000 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c30010 ENOG4105EHG Permease protein VAPA_1c30030 ENOG4108YZT Adenosylcobinamide kinase VAPA_1c30040 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VAPA_1c30080 ENOG4105HF0 Membrane VAPA_1c30100 ENOG41063TF transcriptional regulator (AraC VAPA_1c30110 ENOG4105ES4 Nitrilase VAPA_1c30140 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c30170 ENOG4105DRR Transcriptional regulator, GntR family VAPA_1c30180 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) VAPA_1c30200 ENOG4107EXU Short-chain dehydrogenase reductase Sdr VAPA_1c30210 ENOG4105CBN LysR family transcriptional regulator VAPA_1c30220 ENOG4106NZI LysR family Transcriptional regulator VAPA_1c30230 ENOG4105C01 Dihydroxy-acid dehydratase VAPA_1c30250 ENOG4105W2Z cytochrome C, class I VAPA_1c30270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VAPA_1c30280 ENOG4108TEB UPF0114 protein VAPA_1c30290 ENOG4105EJC lysr family transcriptional regulator VAPA_1c30300 ENOG4108RYK Nad-dependent epimerase dehydratase VAPA_1c30320 ENOG4108IJ7 Glycine betaine VAPA_1c30330 ENOG4108HQS Glycine betaine VAPA_1c30340 ENOG4105GIJ Glycine betaine VAPA_1c30430 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VAPA_1c30440 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) VAPA_1c30450 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VAPA_1c30460 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation VAPA_1c30490 ENOG4105ENT Efflux transporter rnd family, mfp subunit VAPA_1c30500 ENOG4105DFH Transport of potassium into the cell (By similarity) VAPA_1c30520 ENOG4105FE1 phytoene synthase VAPA_1c30530 ENOG4105CVN desaturase VAPA_1c30560 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant VAPA_1c30570 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) VAPA_1c30620 ENOG4108IV0 ABC, transporter VAPA_1c30670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAPA_1c30770 ENOG4105DHQ Histidine kinase VAPA_1c30780 ENOG4105VEJ Heat shock protein VAPA_1c30790 ENOG4105CSR polyphosphate kinase 2 VAPA_1c30830 ENOG4105GKE subunit e VAPA_1c30840 ENOG4107QIZ NADH dehydrogenase VAPA_1c30850 ENOG4108JB9 formate dehydrogenase VAPA_1c30860 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VAPA_1c30880 ENOG4105D2N Aldolase VAPA_1c30890 ENOG4105BZA Phosphoglycerate kinase VAPA_1c30900 ENOG4105CV1 Transketolase (EC 2.2.1.1) VAPA_1c30910 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) VAPA_1c30920 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 VAPA_1c30940 ENOG4105DJV ribulose-phosphate 3-epimerase VAPA_1c30960 ENOG4106F1P AAA ATPase, central domain protein VAPA_1c30980 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate VAPA_1c30990 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c31010 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c31060 ENOG4105DZG Dehydrogenase VAPA_1c31070 ENOG4105WJN methanol dehydrogenase-like protein, cytochrome cL (XoxG) VAPA_1c31130 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VAPA_1c31190 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E VAPA_1c31200 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d VAPA_1c31220 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) VAPA_1c31240 ENOG4105BZU Histidine kinase VAPA_1c31250 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c31300 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) VAPA_1c31310 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A VAPA_1c31370 ENOG4105I9Z UPF0264 protein VAPA_1c31410 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VAPA_1c31430 ENOG4108P4C Formaldehyde-activating enzyme VAPA_1c31460 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) VAPA_1c31480 ENOG4108M6X Dehydrogenase VAPA_1c31540 ENOG4105CFH Aspartokinase VAPA_1c31550 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) VAPA_1c31560 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) VAPA_1c31580 ENOG4105C8N cysteinyl-tRNA synthetase VAPA_1c31620 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) VAPA_1c31670 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division VAPA_1c31680 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VAPA_1c31690 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) VAPA_1c31760 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VAPA_1c31770 ENOG4108R6K riboflavin synthase, subunit alpha VAPA_1c31780 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) VAPA_1c31790 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) VAPA_1c31800 ENOG4107YIM Involved in the transcription termination process (By similarity) VAPA_1c31810 ENOG4105CHM Aminotransferase VAPA_1c31820 ENOG4107YD3 Thioesterase VAPA_1c31830 ENOG4105E02 MotA TolQ exbB proton channel VAPA_1c31840 ENOG4108ZZF transport protein (ExbD) VAPA_1c31860 ENOG4105C0B DNA polymerase III (alpha subunit) VAPA_1c31870 ENOG4105C72 UPF0176 protein VAPA_1c31920 ENOG4105EUB pirin domain protein VAPA_1c31980 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) VAPA_1c31990 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) VAPA_1c32000 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) VAPA_1c32020 ENOG4105IJJ transcriptional regulator, crp fnr family VAPA_1c32040 ENOG4105MP9 class II Aldolase VAPA_1c32060 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VAPA_1c32070 ENOG41079YP Citrate utilization protein b VAPA_1c32080 ENOG4105MP9 class II Aldolase VAPA_1c32110 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c32140 ENOG4107QK4 glycoside hydrolase, family 3 domain protein VAPA_1c32160 ENOG4105HSS phospholipase C VAPA_1c32180 ENOG4105D5T phosphonate abc transporter VAPA_1c32200 ENOG4105D4U had-superfamily hydrolase, subfamily iia VAPA_1c32210 ENOG4106KNT transcriptional regulator VAPA_1c32280 ENOG4108IV0 ABC, transporter VAPA_1c32290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c32320 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein VAPA_1c32330 ENOG4105BZU Histidine kinase VAPA_1c32340 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAPA_1c32370 ENOG4105BZU Histidine kinase VAPA_1c32400 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions VAPA_1c32440 ENOG4105CD8 aminopeptidase N VAPA_1c32450 ENOG4108Z9W Outer membrane porin VAPA_1c32520 ENOG4105C26 Dehydrogenase VAPA_1c32530 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) VAPA_1c32540 ENOG4105C7K acetolactate synthase VAPA_1c32550 ENOG4105CHR reductase VAPA_1c32560 ENOG4107HP6 Transcriptional regulator VAPA_1c32570 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) VAPA_1c32610 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_1c32620 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VAPA_1c32630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VAPA_1c32680 ENOG4105UPP uncharacterized protein ydcA VAPA_1c32910 ENOG4105C30 Nad-dependent epimerase dehydratase VAPA_1c32970 ENOG4106CD9 glycosyl transferase group 1 VAPA_1c32980 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c33040 ENOG4105C0B DNA polymerase III (alpha subunit) VAPA_1c33050 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA VAPA_1c33080 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c33090 ENOG4108Z9W Outer membrane porin VAPA_1c33100 ENOG4105C01 Dihydroxy-acid dehydratase VAPA_1c33160 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c33180 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b VAPA_1c33200 ENOG4105BZ1 (ABC) transporter VAPA_1c33220 ENOG4108RZE Tetr family transcriptional regulator VAPA_1c33250 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VAPA_1c33270 ENOG4105C7W Xanthine dehydrogenase VAPA_1c33280 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding VAPA_1c33290 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit VAPA_1c33320 ENOG4108UT2 hemolysin iii VAPA_1c33340 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) VAPA_1c33360 ENOG4105MHT Transcriptional regulator, ARSR family VAPA_1c33380 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase VAPA_1c33390 ENOG4105CYM Glutathione S-transferase VAPA_1c33440 ENOG4105ER2 Ompa motb domain protein VAPA_1c33500 ENOG4108R3E Dna-3-methyladenine glycosylase i VAPA_1c33520 ENOG4105DXD 2-methylcitrate dehydratase VAPA_1c33530 ENOG4105BZN citrate synthase VAPA_1c33570 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) VAPA_1c33580 ENOG4105DZ2 Transcriptional regulator VAPA_1c33590 ENOG4105ETT transcriptional Regulator, LysR family VAPA_1c33620 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VAPA_1c33630 ENOG4105E39 Enoyl-CoA hydratase VAPA_1c33640 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c33660 ENOG4105C26 Dehydrogenase VAPA_1c33690 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F VAPA_1c33750 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase VAPA_1c33760 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase VAPA_1c33770 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c33780 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c33790 ENOG4105EXG Transcriptional regulator VAPA_1c33800 ENOG4105C26 Dehydrogenase VAPA_1c33830 ENOG4108V1T peptidylprolyl cis-trans isomerase VAPA_1c33840 ENOG4105CUB amino acid VAPA_1c33850 ENOG4105CPD ethanolamine ammonia-lyase VAPA_1c33860 ENOG4107FQ9 ethanolamine ammonia-lyase VAPA_1c33910 ENOG4105DIJ Phosphoethanolamine transferase VAPA_1c33920 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase VAPA_1c33940 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_1c33950 ENOG4105DHQ Histidine kinase VAPA_1c33970 ENOG4105CHR reductase VAPA_1c33980 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VAPA_1c34000 ENOG4107RGD Major Facilitator superfamily VAPA_1c34010 ENOG4105CFM UPF0317 protein VAPA_1c34020 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) VAPA_1c34030 ENOG4105EXW epimerase dehydratase VAPA_1c34040 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_1c34060 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c34080 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) VAPA_1c34090 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) VAPA_1c34100 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor VAPA_1c34140 ENOG4107QWG 2-Nitropropane dioxygenase VAPA_1c34150 ENOG4105ZXK Dehydrogenase VAPA_1c34160 ENOG4106IUH DTW domain containing protein VAPA_1c34170 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) VAPA_1c34210 ENOG4105CSH Transporter VAPA_1c34220 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase VAPA_1c34240 ENOG4105C2C drug resistance transporter, Bcr CflA VAPA_1c34250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase VAPA_1c34260 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase VAPA_1c34270 ENOG4107V59 shikimate VAPA_1c34280 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_1c34290 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c34300 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter VAPA_1c34310 ENOG4105E2X shikimate dehydrogenase VAPA_1c34320 ENOG4107HP6 Transcriptional regulator VAPA_1c34340 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_1c34380 ENOG41064T2 transcriptional regulator, lysR family VAPA_1c34450 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator VAPA_1c34470 ENOG41088CQ domain protein VAPA_1c34490 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase VAPA_1c34520 ENOG41082BM Transcriptional regulator, arsr family VAPA_1c34540 ENOG4105CXK mandelate racemase muconate lactonizing VAPA_1c34550 ENOG4105CSP Major Facilitator Superfamily VAPA_1c34560 ENOG4106517 Short-chain dehydrogenase reductase Sdr VAPA_1c34610 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VAPA_1c34620 ENOG4105C4M (Ubiquinol oxidase) subunit I VAPA_1c34630 ENOG4108JJ8 (ABC) transporter VAPA_1c34640 ENOG4108JJ9 ABC, transporter VAPA_1c34670 ENOG4105CSU acyl-Coa dehydrogenase VAPA_1c34680 ENOG4105C10 Electron transfer flavoprotein VAPA_1c34690 ENOG4105BZJ Electron transfer flavoprotein VAPA_1c34700 ENOG4105EGS Mechanosensitive ion channel VAPA_1c34710 ENOG4105DGU Histone deacetylase VAPA_1c34720 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VAPA_1c34740 ENOG4105F8C transglutaminase domain-containing protein VAPA_1c34750 ENOG4105CVE Lytic murein transglycosylase VAPA_1c34810 ENOG4105CJ1 ABC, transporter VAPA_1c34880 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component VAPA_1c34900 ENOG4108IJ9 (ABC) transporter VAPA_1c34910 ENOG4108IJ9 (ABC) transporter VAPA_1c34920 ENOG4105C6V Glycerol-3-phosphate dehydrogenase VAPA_1c34930 ENOG4105E98 transcriptional regulator DeoR family VAPA_1c34950 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) VAPA_1c35000 ENOG4108EC8 DNA internalization-related competence protein ComEC VAPA_1c35050 ENOG4105ENE Histidine kinase VAPA_1c35060 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c35110 ENOG4107RSM transcriptional regulator VAPA_1c35120 ENOG4108Z4U Ferredoxin VAPA_1c35160 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component VAPA_1c35190 ENOG4108M60 Transcriptional regulator VAPA_1c35200 ENOG4105C5I Dehydrogenase VAPA_1c35210 ENOG4105D7K pfkb domain protein VAPA_1c35230 ENOG4105CDA abc transporter atp-binding protein VAPA_1c35240 ENOG4105EAB amino acid AbC transporter VAPA_1c35250 ENOG4105E5Q amino acid AbC transporter VAPA_1c35260 ENOG4105E5Q amino acid AbC transporter VAPA_1c35320 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAPA_1c35340 ENOG4105E4C Lytic transglycosylase catalytic VAPA_1c35350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAPA_1c35390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VAPA_1c35400 ENOG4105GJM (LipO)protein VAPA_1c35410 ENOG4105Q2H domain protein VAPA_1c35440 ENOG4105EZE Cupin 4 family protein VAPA_1c35450 ENOG4108YZY peptidylprolyl cis-trans isomerase VAPA_1c35470 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) VAPA_1c35490 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase VAPA_1c35500 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) VAPA_1c35510 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VAPA_1c35530 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) VAPA_1c35540 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VAPA_1c35550 ENOG4106Z1T Nicotinamide Mononucleotide Transporter VAPA_1c35580 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) VAPA_1c35590 ENOG4108Z0R Transferase VAPA_1c35600 ENOG4105ED9 Protein of unknown function (DUF455) VAPA_1c35620 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c35650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VAPA_1c35680 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VAPA_1c35690 ENOG4105K8N protein family UPF0079, ATPase VAPA_1c35700 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VAPA_1c35720 ENOG4105DQR SNARE associated Golgi VAPA_1c35740 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) VAPA_1c35760 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) VAPA_1c35770 ENOG4108I0Y (ABC) transporter VAPA_1c35800 ENOG4105EV8 ectoine hydroxylase VAPA_1c35820 ENOG4105GRZ Ycii-related protein VAPA_1c35830 ENOG4105CHP RNA polymerase VAPA_1c35900 ENOG4107T31 5'-nucleotidase VAPA_1c35920 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c35940 ENOG4108IV0 ABC, transporter VAPA_1c35950 ENOG4105C0Z ABC transporter VAPA_1c35970 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAPA_1c35980 ENOG4105CW7 secretion protein, HlyD family VAPA_1c36000 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes VAPA_1c36010 ENOG4105BZ1 (ABC) transporter VAPA_1c36050 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_1c36060 ENOG4105C8S subunit m VAPA_1c36080 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_1c36090 ENOG4105DF2 NADH dehydrogenase subunit j VAPA_1c36100 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_1c36110 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) VAPA_1c36120 ENOG4108IEH NADH dehydrogenase subunit g VAPA_1c36130 ENOG4107QIZ NADH dehydrogenase VAPA_1c36150 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_1c36160 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain VAPA_1c36170 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_1c36180 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain VAPA_1c36200 ENOG4107EJC Preprotein translocase subunit SecG VAPA_1c36210 ENOG4105CP7 Triose-phosphate isomerase VAPA_1c36230 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) VAPA_1c36240 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) VAPA_1c36250 ENOG4105CHM Aminotransferase VAPA_1c36260 ENOG4105ES9 amino acid VAPA_1c36290 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VAPA_1c36310 ENOG4105I5W Transporter VAPA_1c36330 ENOG4105D7T ABC transporter VAPA_1c36370 ENOG4108IFG nitrite reductase, (NAD(P)H) VAPA_1c36400 ENOG4108I0Q anthranilate phosphoribosyltransferase VAPA_1c36410 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VAPA_1c36430 ENOG4105E4G Type IV pilus VAPA_1c36440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c36460 ENOG4105F38 ABC transporter, permease VAPA_1c36470 ENOG4105EG2 ABC transporter, permease VAPA_1c36490 ENOG4108UY0 (LipO)protein VAPA_1c36500 ENOG4105CBX hi0933 family VAPA_1c36510 ENOG4105VCC 30S ribosomal protein S21 VAPA_1c36520 ENOG4105KTH gatB Yqey VAPA_1c36530 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) VAPA_1c36600 ENOG4107SM8 Adenylate Guanylate cyclase VAPA_1c36630 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VAPA_1c36640 ENOG4108KAM Transcriptional regulator VAPA_1c36650 ENOG4108NKV transcriptional regulator VAPA_1c36670 ENOG4105CMS peptidase U62, modulator of DNA gyrase VAPA_1c36680 ENOG4105N42 UPF0307 protein VAPA_1c36690 ENOG4108RIR Molybdenum cofactor biosynthesis protein VAPA_1c36810 ENOG4105W1Y Transcriptional regulator VAPA_1c36820 ENOG4105D7W serine acetyltransferase VAPA_1c36840 ENOG4105ECY inositol monophosphatase VAPA_1c36900 ENOG4105DDW LysR family Transcriptional regulator VAPA_1c36920 ENOG4108VHT MarR family transcriptional regulator VAPA_1c36940 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c36950 ENOG4105ENH Sulfatase VAPA_1c36970 ENOG4105BZU Histidine kinase VAPA_1c37000 ENOG4105CA0 peroxidase VAPA_1c37040 ENOG4105Q26 Siderophore-interacting protein VAPA_1c37050 ENOG4105D7N magnesium and cobalt transport protein CorA VAPA_1c37070 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) VAPA_1c37180 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAPA_1c37220 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) VAPA_1c37240 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c37250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VAPA_1c37260 ENOG4106G6Q Transcriptional regulator VAPA_1c37280 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VAPA_1c37290 ENOG4105BZS acriflavin resistance protein VAPA_1c37300 ENOG4105BZS acriflavin resistance protein VAPA_1c37310 ENOG4105ENT Efflux transporter rnd family, mfp subunit VAPA_1c37340 ENOG4105C2F Histidine kinase VAPA_1c37350 ENOG4108VAC response regulator VAPA_1c37370 ENOG4105CX6 glutaminyL-tRNA synthetase VAPA_1c37420 ENOG4108VAC response regulator VAPA_1c37470 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) VAPA_1c37510 ENOG4105VUF Transcriptional regulator VAPA_1c37530 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr VAPA_1c37540 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VAPA_1c37550 ENOG4105D9M gamma-glutamylcysteine synthetase VAPA_1c37590 ENOG4105CKI cobalamin synthesis protein VAPA_1c37620 ENOG4105CSH Transporter VAPA_1c37670 ENOG4105CKW Inner membrane protein yedI VAPA_1c37700 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VAPA_1c37730 ENOG4105D3G Pseudouridine synthase VAPA_1c37740 ENOG41068KF Universal stress protein VAPA_1c37770 ENOG41067HS methyltransferase VAPA_1c37780 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process VAPA_1c37790 ENOG4105CEP NADH dehydrogenase VAPA_1c37820 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c37830 ENOG4108Z9K Osmotically inducible protein VAPA_1c37860 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c37870 ENOG4105DRP amino acid AbC transporter VAPA_1c37880 ENOG4105E5Q amino acid AbC transporter VAPA_1c37910 ENOG4108WAV Transcriptional regulator VAPA_1c37950 ENOG4107VXM glycerophosphoryl diester phosphodiesterase VAPA_1c37980 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_1c37990 ENOG4105KXX peptidase s58 dmpa VAPA_1c38010 ENOG4105VUF Transcriptional regulator VAPA_1c38030 ENOG4105C5H ABC transporter VAPA_1c38040 ENOG4105C1J atp-dependent rna helicase VAPA_1c38100 ENOG4105D56 permease protein VAPA_1c38120 ENOG4107EJG GntR family transcriptional regulator VAPA_1c38130 ENOG4105C01 Dihydroxy-acid dehydratase VAPA_1c38140 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 VAPA_1c38150 ENOG4108RTU Aldolase VAPA_1c38160 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase VAPA_1c38180 ENOG4105CHR reductase VAPA_1c38260 ENOG4108UCS ABC, transporter VAPA_1c38280 ENOG4108UYE Lactoylglutathione lyase VAPA_1c38320 ENOG4108UHU Aldolase VAPA_1c38330 ENOG4105C01 Dihydroxy-acid dehydratase VAPA_1c38370 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VAPA_1c38380 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) VAPA_1c38410 ENOG4105RK9 auxin efflux carrier VAPA_1c38440 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VAPA_1c38450 ENOG4105YA8 Transcriptional regulator VAPA_1c38460 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) VAPA_1c38490 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase VAPA_1c38500 ENOG4107QKV phosphomannomutase VAPA_1c38530 ENOG4107RT3 EamA-like transporter family VAPA_1c38570 ENOG4105CYM Glutathione S-transferase VAPA_1c38610 ENOG4105IBP Cyclic peptide transporter VAPA_1c38630 ENOG4108V3E phosphoribosylglycinamide formyltransferase VAPA_1c38650 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) VAPA_1c38660 ENOG4105E0K tonB-dependent siderophore receptor VAPA_1c38820 ENOG4107S4Y M20 DapE family protein YgeY VAPA_1c38870 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) VAPA_1c38880 ENOG4105C28 cystathionine VAPA_1c38890 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase VAPA_1c38920 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase VAPA_1c38930 ENOG4105KUZ arsenate reductase VAPA_1c38950 ENOG4105NBK UPF0345 protein VAPA_1c38960 ENOG4105CDH Citrulline--aspartate ligase VAPA_1c38980 ENOG4105D4A Cell wall formation (By similarity) VAPA_1c38990 ENOG4108VPT UPF0234 protein VAPA_1c39010 ENOG4105M4H endoribonuclease L-psp VAPA_1c39020 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) VAPA_1c39030 ENOG4108Z66 YbaK ebsC protein VAPA_1c39040 ENOG4105CPC Aldo Keto reductase VAPA_1c39080 ENOG4105D01 (LipO)protein VAPA_1c39090 ENOG4108UMI ABC transporter, permease VAPA_1c39100 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c39110 ENOG4105D01 (LipO)protein VAPA_1c39120 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) VAPA_1c39130 ENOG4107VXZ Hydrolase VAPA_1c39140 ENOG4105CD8 aminopeptidase N VAPA_1c39150 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 VAPA_1c39210 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit VAPA_1c39220 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding VAPA_1c39230 ENOG4105C7W Xanthine dehydrogenase VAPA_1c39240 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein VAPA_1c39250 ENOG4108KDI dmso reductase anchor subunit VAPA_1c39260 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein VAPA_1c39270 ENOG4105DB1 molybdopterin oxidoreductase VAPA_1c39280 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c39300 ENOG4105FDP GntR family transcriptional regulator VAPA_1c39310 ENOG4105VP7 SAF domain protein VAPA_1c39320 ENOG4105CTX dehydratase VAPA_1c39330 ENOG4108JQ1 Dehydrogenase VAPA_1c39340 ENOG4105DG4 malate L-lactate dehydrogenase VAPA_1c39360 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VAPA_1c39380 ENOG4108FUF Transcriptional regulator, IclR family VAPA_1c39430 ENOG4108EKI Dehydrogenase VAPA_1c39440 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c39470 ENOG4108FUF Transcriptional regulator, IclR family VAPA_1c39480 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) VAPA_1c39490 ENOG4105CSH Transporter VAPA_1c39540 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding VAPA_1c39550 ENOG4105CR8 Transcriptional regulator VAPA_1c39560 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component VAPA_1c39570 ENOG4108IY8 ABC, transporter VAPA_1c39580 ENOG4106FTQ Taurine ABC transporter, periplasmic VAPA_1c39600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAPA_1c39650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_1c39670 ENOG4108JQ7 (ABC) transporter VAPA_1c39680 ENOG4105CI2 imidazolone-5-propionate hydrolase VAPA_1c39750 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) VAPA_1c39780 ENOG4105CS6 Rhs element vgr protein VAPA_1c39820 ENOG4105GVF (ABC) transporter VAPA_1c39840 ENOG4105E2Y ABC, transporter VAPA_1c39850 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VAPA_1c39860 ENOG4107Z6I Thiamine biosynthesis protein VAPA_1c39900 ENOG4105FDT acyl-CoA dehydrogenase VAPA_1c39910 ENOG4105GVF (ABC) transporter VAPA_1c39920 ENOG4108T2C cysteine dioxygenase type I VAPA_1c39950 ENOG4105C1J atp-dependent rna helicase VAPA_1c39960 ENOG4105CGZ zinc metallopeptidase VAPA_1c39970 ENOG4105DHP deoxycytidine triphosphate deaminase VAPA_1c39980 ENOG4107QUY Guanine deaminase VAPA_1c40010 ENOG4105CBN LysR family transcriptional regulator VAPA_1c40030 ENOG4107SQI penicillin amidase VAPA_1c40040 ENOG41063TF transcriptional regulator (AraC VAPA_1c40060 ENOG4107RDB Major Facilitator VAPA_1c40070 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) VAPA_1c40080 ENOG4105W2Z cytochrome C, class I VAPA_1c40100 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein VAPA_1c40150 ENOG4105GAK amidohydrolase 2 VAPA_1c40180 ENOG4105CI0 Citrate lyase VAPA_1c40190 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) VAPA_1c40220 ENOG4105UIB (ABC) transporter VAPA_1c40230 ENOG4108JQ9 ABC transporter VAPA_1c40240 ENOG4105C7N Xanthine uracil vitamin C permease VAPA_1c40260 ENOG4105C7W Xanthine dehydrogenase VAPA_1c40300 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c40330 ENOG4105EKQ RNA-directed DNA polymerase VAPA_1c40340 ENOG4105DKB L-sorbosone dehydrogenase VAPA_1c40500 ENOG4105VT2 5-hydroxyisourate hydrolase VAPA_1c40510 ENOG4107YCY Transcriptional regulator VAPA_1c40540 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VAPA_1c40550 ENOG4105DRR Transcriptional regulator, GntR family VAPA_1c40570 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter VAPA_1c40580 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c40590 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_1c40610 ENOG4105CHR reductase VAPA_1c40630 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VAPA_1c40650 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c40690 ENOG4105CHR reductase VAPA_1c40700 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c40710 ENOG4106517 Short-chain dehydrogenase reductase Sdr VAPA_1c40730 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease VAPA_1c40800 ENOG4105C2W permease VAPA_1c40810 ENOG4105CV8 reductase VAPA_1c40820 ENOG4105BZU Histidine kinase VAPA_1c40830 ENOG4108ZXC Two component transcriptional regulator, luxr family VAPA_1c40840 ENOG4105CSH Transporter VAPA_1c40870 ENOG4105CK2 sodium dicarboxylate symporter VAPA_1c40890 ENOG4105F4G Membrane VAPA_1c40920 ENOG4105CC0 LysR family Transcriptional regulator VAPA_1c40930 ENOG41060W2 glyoxylate carboligase VAPA_1c40940 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) VAPA_1c40950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VAPA_1c40970 ENOG4105C6K Malic enzyme VAPA_1c40980 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VAPA_1c41000 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c41010 ENOG41062YB Trap dicarboxylate transporter, dctp subunit VAPA_1c41030 ENOG4105D7T ABC transporter VAPA_1c41040 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component VAPA_1c41140 ENOG4105EW9 transcriptional regulator AsnC family VAPA_1c41150 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_1c41180 ENOG4108Z6B deaminase VAPA_1c41190 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) VAPA_1c41210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VAPA_1c41230 ENOG4107NQ8 LysR family Transcriptional regulator VAPA_1c41310 ENOG4105E0K tonB-dependent siderophore receptor VAPA_1c41320 ENOG4105VCD cytoplasmic protein VAPA_1c41330 ENOG4105D22 carbon starvation protein VAPA_1c41360 ENOG4105K4H Nlp p60 protein VAPA_1c41480 ENOG4105CPC Aldo Keto reductase VAPA_1c41490 ENOG4105DGI Alkaline phosphatase VAPA_1c41500 ENOG4108QXE glycerophosphoryl diester phosphodiesterase VAPA_1c41510 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component VAPA_1c41520 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component VAPA_1c41550 ENOG4105DKT Transcriptional regulator VAPA_1c41560 ENOG4105F27 Major Facilitator VAPA_1c41570 ENOG4108IV0 ABC, transporter VAPA_1c41580 ENOG4105C0Z ABC transporter VAPA_1c41600 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c41610 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein VAPA_1c41660 ENOG4105CSR polyphosphate kinase 2 VAPA_1c41680 ENOG4105DB7 PHP domain protein VAPA_1c41700 ENOG4107RTD sua5 ycio yrdc ywlc family protein VAPA_1c41710 ENOG4108Z4T Peptidase M50 VAPA_1c41720 ENOG4105C31 Tryptophanyl-tRNA synthetase VAPA_1c41730 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c41760 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) VAPA_1c41770 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase VAPA_1c41780 ENOG4105C7B Threonine dehydratase VAPA_1c41790 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) VAPA_1c41800 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase VAPA_1c41810 ENOG4105W5Q DNA repair protein (RadC VAPA_1c41820 ENOG4108DG9 Smr protein MutS2 VAPA_1c41850 ENOG4105RKW reductase (By VAPA_1c41860 ENOG4106PMH Extracellular solute-binding protein family 3 VAPA_1c41870 ENOG4105EAD ABC transporter VAPA_1c41880 ENOG4105DRP amino acid AbC transporter VAPA_1c41910 ENOG4107VXZ Hydrolase VAPA_1c41920 ENOG4105CSH Transporter VAPA_1c41930 ENOG4105E2S oxidase) subunit II VAPA_1c41940 ENOG4105BZ9 Cytochrome C oxidase, subunit I VAPA_1c41950 ENOG4105CCU oxidase (Subunit III) VAPA_1c41960 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) VAPA_1c41980 ENOG4105TX3 Histidine kinase VAPA_1c41990 ENOG4108UYB regulatoR VAPA_1c42000 ENOG4108UT2 hemolysin iii VAPA_1c42010 ENOG41069P5 Protein slyX homolog VAPA_1c42020 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr VAPA_1c42030 ENOG4105CHR reductase VAPA_1c42040 ENOG4105CBN LysR family transcriptional regulator VAPA_1c42050 ENOG4105C57 major facilitator superfamily VAPA_1c42060 ENOG4105CC0 LysR family Transcriptional regulator VAPA_1c42080 ENOG4105CV6 ABC transporter, permease VAPA_1c42090 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VAPA_1c42130 ENOG4105QAX Iron-sulfur VAPA_1c42140 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VAPA_1c42200 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c42210 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein VAPA_1c42220 ENOG4105E0C molybdate abc transporter VAPA_1c42230 ENOG4105F4R Transcriptional regulator mode VAPA_1c42240 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VAPA_1c42260 ENOG4105C5Q Transcriptional regulator VAPA_1c42320 ENOG4108YXG UPF0502 protein VAPA_1c42330 ENOG4108T58 Mg2 transport protein CorA VAPA_1c42340 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAPA_1c42350 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) VAPA_1c42380 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c42410 ENOG4105CHH sulfate transporter VAPA_1c42470 ENOG4108IYU L-aspartate oxidase VAPA_1c42480 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) VAPA_1c42490 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) VAPA_1c42520 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) VAPA_1c42530 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase VAPA_1c42540 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase VAPA_1c42550 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) VAPA_1c42570 ENOG4105WZW rhodanese family VAPA_1c42580 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) VAPA_1c42590 ENOG4105CN1 protease VAPA_1c42600 ENOG4105D06 uba thif-type nad fad binding protein VAPA_1c42610 ENOG41066T0 asmA family VAPA_1c42630 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c42640 ENOG4105BZU Histidine kinase VAPA_1c42700 ENOG4105K3G Periplasmic Protein VAPA_1c42720 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) VAPA_1c42740 ENOG4105EUJ GTP cyclohydrolase i VAPA_1c42750 ENOG4105X23 Endonuclease Exonuclease phosphatase VAPA_1c42760 ENOG4108TIT dATP pyrophosphohydrolase VAPA_1c42770 ENOG4105C9M aspartyl-trna synthetase VAPA_1c42800 ENOG4105CK7 Sodium proline symporter VAPA_1c42810 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) VAPA_1c42840 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VAPA_1c42880 ENOG4108JQ1 Dehydrogenase VAPA_1c42900 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component VAPA_1c42920 ENOG4108IJ9 (ABC) transporter VAPA_1c42930 ENOG4107T6V glycerophosphoryl diester phosphodiesterase VAPA_1c42940 ENOG4105EGS Mechanosensitive ion channel VAPA_1c42950 ENOG4105D00 flagellar biosynthetic protein flhB VAPA_1c42960 ENOG4105D7B Flagellar biosynthesis protein flha VAPA_1c42970 ENOG4105FZW flagellar biosynthesis regulator FlhF VAPA_1c42970 ENOG4105FZW flagellar biosynthesis regulator FlhF VAPA_1c42990 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAPA_1c43010 ENOG4107TPS domain protein VAPA_1c43060 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) VAPA_1c43070 ENOG4108VYJ response regulator receiver protein VAPA_1c43090 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) VAPA_1c43100 ENOG4105BZU Histidine kinase VAPA_1c43110 ENOG4105D58 Diguanylate phosphodiesterase VAPA_1c43120 ENOG4105CBS Chea signal transduction histidine kinase VAPA_1c43130 ENOG4105ER2 Ompa motb domain protein VAPA_1c43140 ENOG4107RD7 Flagellar Motor Protein, MotA VAPA_1c43150 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region VAPA_1c43200 ENOG4105MQ3 flagellar protein FliS VAPA_1c43210 ENOG4105DTS flagellar hook-associated VAPA_1c43220 ENOG41063QE flagellar protein FlaG VAPA_1c43240 ENOG4105VQ0 flagellar hook-basal body complex protein fliE VAPA_1c43250 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) VAPA_1c43260 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VAPA_1c43270 ENOG4108CG0 Flagellar assembly protein VAPA_1c43280 ENOG4108JIR Flagellum-specific ATP synthase VAPA_1c43290 ENOG4105GSA Flagellar export protein flij VAPA_1c43310 ENOG4107ZI8 flagellar basal body-associated protein flil VAPA_1c43320 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VAPA_1c43330 ENOG4105DD5 Flagellar motor switch protein VAPA_1c43350 ENOG4105CN7 Flagellar biosynthetic protein FliP VAPA_1c43360 ENOG4105VS8 Flagellar biosynthetic protein fliq VAPA_1c43370 ENOG4105D19 Role in flagellar biosynthesis (By similarity) VAPA_1c43380 ENOG4105DTJ flagellar hook-associated protein VAPA_1c43390 ENOG4105E1Q flagellar hook-associated protein VAPA_1c43400 ENOG4105C8Q Methyl-accepting chemotaxis VAPA_1c43410 ENOG4105C8Q Methyl-accepting chemotaxis VAPA_1c43420 ENOG4108V3W Chemotaxis protein, CheW VAPA_1c43430 ENOG4105C8Q Methyl-accepting chemotaxis VAPA_1c43440 ENOG4105C8Q Methyl-accepting chemotaxis VAPA_1c43450 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VAPA_1c43460 ENOG4105C8Q Methyl-accepting chemotaxis VAPA_1c43470 ENOG4108V3W Chemotaxis protein, CheW VAPA_1c43480 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj VAPA_1c43490 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VAPA_1c43500 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VAPA_1c43510 ENOG4105CGA flagellar basal-body rod protein FlgG VAPA_1c43520 ENOG4108KPB Flagellar basal-body rod protein FlgF VAPA_1c43530 ENOG4105BZE flagellar hook protein, FlgE VAPA_1c43540 ENOG4105W00 Flagellar hook capping protein VAPA_1c43550 ENOG4108ZC9 flagellar basal-body rod protein flgc VAPA_1c43560 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) VAPA_1c43620 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) VAPA_1c43630 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) VAPA_1c43640 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) VAPA_1c43670 ENOG4105C37 (CBS) domain VAPA_1c43680 ENOG4105E4C Lytic transglycosylase catalytic VAPA_1c43690 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) VAPA_1c43700 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) VAPA_1c43720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) VAPA_1c43730 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control VAPA_1c43740 ENOG4105K46 50S ribosomal protein l27 VAPA_1c43750 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) VAPA_1c43760 ENOG4105EAH synthase VAPA_1c43780 ENOG4107QHF type ii secretion system protein e VAPA_1c43820 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein VAPA_1c43840 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) VAPA_1c43850 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) VAPA_1c43860 ENOG4105EXC Acyl-transferase VAPA_1c43870 ENOG4105M6F mutator MutT protein VAPA_1c43890 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) VAPA_1c43900 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VAPA_1c43930 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit VAPA_1c43940 ENOG4105RQF LysR family Transcriptional regulator VAPA_1c43970 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAPA_1c43980 ENOG4105BZU Histidine kinase VAPA_1c43990 ENOG4108YZ9 Urea amidohydrolase subunit gamma VAPA_1c44010 ENOG4105KI2 Urea amidohydrolase subunit beta VAPA_1c44020 ENOG4105CQM Urea amidohydrolase subunit alpha VAPA_1c44050 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) VAPA_1c44060 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) VAPA_1c44070 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) VAPA_1c44110 ENOG4108Z9W Outer membrane porin VAPA_1c44130 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane VAPA_1c44140 ENOG4105E3W Two component transcriptional regulator (Winged helix family VAPA_1c44180 ENOG4105EB3 Histidine kinase VAPA_1c44190 ENOG4105E3W Two component transcriptional regulator (Winged helix family VAPA_1c44210 ENOG41066T0 asmA family VAPA_1c44270 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VAPA_1c44340 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c44360 ENOG4107RRE RNA-directed DNA polymerase VAPA_1c44660 ENOG4105UZW Tail fiber assembly protein VAPA_1c44850 ENOG4108R7K Metal Dependent Phosphohydrolase VAPA_1c44880 ENOG4105DFP Integrase VAPA_1c44900 ENOG4105CSA Coproporphyrinogen iii oxidase VAPA_1c44910 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VAPA_1c44940 ENOG4105D9P serine threonine protein kinase VAPA_1c44950 ENOG4105DSJ YicC domain protein VAPA_1c44960 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) VAPA_1c44970 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) VAPA_1c44980 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VAPA_1c44990 ENOG4108RRZ Transcription elongation factor GreB VAPA_1c45010 ENOG4108EJ0 Catalyzes the synthesis of activated sulfate (By similarity) VAPA_1c45040 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) VAPA_1c45050 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) VAPA_1c45060 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) VAPA_1c45070 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) VAPA_1c45080 ENOG4105CEN a g-specific adenine glycosylase VAPA_1c45090 ENOG410890F Dynamin family VAPA_1c45100 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) VAPA_1c45130 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) VAPA_1c45150 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VAPA_1c45160 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) VAPA_1c45170 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) VAPA_1c45190 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding VAPA_1c45210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_1c45230 ENOG4108JQ7 (ABC) transporter VAPA_1c45240 ENOG4105DEF Extracellular solute-binding protein, family 5 VAPA_1c45250 ENOG4105DEF Extracellular solute-binding protein, family 5 VAPA_1c45260 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c45300 ENOG4105F04 LysR family Transcriptional regulator VAPA_1c45360 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VAPA_1c45370 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) VAPA_1c45380 ENOG4105E7W lamb ycsf family protein VAPA_1c45390 ENOG4107R7A Allophanate hydrolase subunit 2 VAPA_1c45400 ENOG4105P4J Allophanate hydrolase, subunit 1 VAPA_1c45410 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) VAPA_1c45420 ENOG4106H78 methyltransferase VAPA_1c45500 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_1c45520 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAPA_1c45530 ENOG4105F1N DNA alkylation repair VAPA_1c45550 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) VAPA_1c45600 ENOG4107QS1 Cytochrome C Oxidase, Subunit III VAPA_1c45620 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) VAPA_1c45640 ENOG4105BZ9 Cytochrome C oxidase, subunit I VAPA_1c45650 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) VAPA_1c45670 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VAPA_1c45680 ENOG4105MJ2 Competence protein VAPA_1c45690 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) VAPA_1c45720 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein VAPA_1c45750 ENOG4105E9F Enoyl-CoA hydratase VAPA_1c45760 ENOG4105E4E Thioester reductase domain-containing protein VAPA_1c45780 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c45790 ENOG4105CSU acyl-Coa dehydrogenase VAPA_1c45820 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase VAPA_1c45860 ENOG4105KCV RNA signal recognition particle 4.5S RNA VAPA_1c45900 ENOG4108T5G Adenylate VAPA_1c45910 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP VAPA_1c45930 ENOG4105E0Y RtcB Protein VAPA_1c45950 ENOG4105CYB regulatoR VAPA_1c45970 ENOG4107XM9 (LipO)protein VAPA_1c45980 ENOG4105CIF Ornithine Cyclodeaminase VAPA_1c46010 ENOG4105E0F Histidine kinase VAPA_1c46020 ENOG4108ZHJ Organic hydroperoxide resistance protein VAPA_1c46030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAPA_1c46070 ENOG4108Z4X TRANSCRIPTIONal VAPA_1c46090 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c46100 ENOG4107QNJ CoA-transferase subunit B VAPA_1c46120 ENOG4107HP6 Transcriptional regulator VAPA_1c46140 ENOG4108Q9V regulatoR VAPA_1c46150 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) VAPA_1c46300 ENOG4108JUA Transcriptional regulator VAPA_1c46330 ENOG4108JJA ABC, transporter VAPA_1c46360 ENOG4105KCK Peptidoglycan-associated lipoprotein VAPA_1c46390 ENOG4105DDW LysR family Transcriptional regulator VAPA_1c46420 ENOG4106RE7 Cytochrome VAPA_1c46430 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VAPA_1c46520 ENOG4105FCD Major Facilitator VAPA_1c46550 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c46560 ENOG4105CA9 Pyruvate kinase VAPA_1c46570 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VAPA_1c46590 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha VAPA_1c46600 ENOG4105CMV Succinyl-CoA synthetase subunit beta VAPA_1c46620 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c46630 ENOG4105BZU Histidine kinase VAPA_1c46650 ENOG4105CFN oxalyl-CoA decarboxylase VAPA_1c46790 ENOG4105KKX ATPase associated with various cellular activities aaa_5 VAPA_1c46800 ENOG4108KDT Molybdate metabolism regulator VAPA_1c46820 ENOG4105DEG Vwa containing coxe family protein VAPA_1c47070 ENOG4107QZV Type I secretion membrane fusion protein VAPA_1c47080 ENOG4108JJA ABC, transporter VAPA_1c47120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAPA_1c47130 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAPA_1c47140 ENOG4105C08 Histidine kinase VAPA_1c47160 ENOG4105DFS Conserved Protein VAPA_1c47280 ENOG4105C9U ATP-dependent DNA helicase RecQ VAPA_1c47290 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) VAPA_1c47490 ENOG4108K01 transcriptional regulator VAPA_1c47540 ENOG4105CD3 dihydroorotase VAPA_1c47550 ENOG4105CXT aspartate transcarbamylase VAPA_1c47560 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) VAPA_1c47570 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) VAPA_1c47580 ENOG4108UJU UPF0301 protein VAPA_1c47590 ENOG4105CVP deoxyribo-dipyrimidine photolyase VAPA_1c47620 ENOG4105CBS Chea signal transduction histidine kinase VAPA_1c47630 ENOG4105C8Q Methyl-accepting chemotaxis VAPA_1c47650 ENOG4105M3Z response regulator VAPA_1c47660 ENOG4108UNF response regulator VAPA_1c47670 ENOG4105VCQ rubredoxin VAPA_1c47690 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase VAPA_1c47700 ENOG4105EUF amidase EC 3.5.1.4 VAPA_1c47730 ENOG4105DC1 bifunctional purine biosynthesis protein purh VAPA_1c47750 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VAPA_1c47760 ENOG4105W39 Membrane VAPA_1c47790 ENOG4105C3G gtp-binding protein VAPA_1c47800 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VAPA_1c47810 ENOG4105C2J ABC transporter VAPA_1c47820 ENOG4105CNN ABC, transporter VAPA_1c47830 ENOG4105ETE Transcriptional regulator (LacI family VAPA_1c47840 ENOG4108RVA ribokinase VAPA_1c47850 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) VAPA_1c47870 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VAPA_1c47880 ENOG4105T95 Thiol disulfide interChange protein VAPA_1c47900 ENOG4105E39 Enoyl-CoA hydratase VAPA_1c47940 ENOG4105CF1 Alkylated DNA repair protein VAPA_1c47950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAPA_1c47980 ENOG4107TJ9 Cytochrome VAPA_1c48000 ENOG4105PGM cation diffusion facilitator family transporter VAPA_1c48010 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) VAPA_1c48020 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase VAPA_1c48030 ENOG4105E8V Alpha Beta Hydrolase Fold protein VAPA_1c48040 ENOG41077RS Phosphatase VAPA_1c48070 ENOG4108HPI phosphatidate Cytidylyltransferase VAPA_1c48100 ENOG4108Z9W Outer membrane porin VAPA_1c48110 ENOG4105CD5 CoA-binding domain protein VAPA_1c48170 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) VAPA_1c48180 ENOG4105C9A Phoh family VAPA_1c48190 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) VAPA_1c48200 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) VAPA_1c48240 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VAPA_1c48250 ENOG4105DR5 peptidase VAPA_1c48260 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) VAPA_1c48270 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAPA_1c48280 ENOG4108YX9 iron--sulfur cluster insertion protein erpA VAPA_1c48290 ENOG4108UJD 30S ribosomal protein S9 VAPA_1c48300 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) VAPA_1c48310 ENOG4105D6S protein involved in catabolism of external DNA VAPA_1c48330 ENOG4105SYT Methylenetetrahydrofolate reductase VAPA_1c48350 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) VAPA_1c48400 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) VAPA_1c48430 ENOG4108IUW ABC transporter VAPA_1c48450 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_1c48460 ENOG41067B5 Histone deacetylase superfamily protein VAPA_1c48470 ENOG4107QWB Ornithine cyclodeaminase VAPA_1c48490 ENOG4108JPW Aminotransferase VAPA_1c48500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c48520 ENOG4105F38 ABC transporter, permease VAPA_1c48530 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component VAPA_1c48540 ENOG4105CYW agmatinase VAPA_1c48550 ENOG4105C26 Dehydrogenase VAPA_1c48560 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VAPA_1c48600 ENOG4105CSH Transporter VAPA_1c48640 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase VAPA_1c48670 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c48700 ENOG4108K8U Glycerol operon regulatory protein VAPA_1c48710 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase VAPA_1c48750 ENOG41060WC Enoyl-CoA hydratase VAPA_1c48760 ENOG4107QX3 carboxylase VAPA_1c48770 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c48780 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c48810 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 VAPA_1c48820 ENOG4105CHR reductase VAPA_1c48830 ENOG4105D3G Pseudouridine synthase VAPA_1c48860 ENOG4108Z6Z Transcriptional regulator VAPA_1c48870 ENOG41077A9 carbonic anhydrase VAPA_1c48880 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) VAPA_1c48890 ENOG4105CHU acetyl-coa acetyltransferase VAPA_1c48910 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c48920 ENOG4105K5B UPF0225 protein VAPA_1c48930 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) VAPA_1c48960 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase VAPA_1c48970 ENOG4105C38 Glycyl-tRNA synthetase beta subunit VAPA_1c48980 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit VAPA_1c48990 ENOG4105CBD Diacylglycerol kinase VAPA_1c49000 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VAPA_1c49010 ENOG410841Q phosphoesterase PA-phosphatase related protein VAPA_1c49050 ENOG4108V9Q carbonic anhydrase VAPA_1c49070 ENOG4105HEI LysR family (Transcriptional regulator VAPA_1c49080 ENOG4105EQ0 Major Facilitator superfamily VAPA_1c49160 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component VAPA_1c49180 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) VAPA_1c49190 ENOG4108JU5 Magnesium and cobalt efflux protein VAPA_1c49210 ENOG4108YXU transcriptional regulator AsnC family VAPA_1c49230 ENOG4105F87 Dehydratase VAPA_1c49240 ENOG4105MIR Phenylalanine 4-monooxygenase VAPA_1c49250 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c49370 ENOG4105C5H ABC transporter VAPA_1c49380 ENOG4107RZC phospholipase d VAPA_1c49400 ENOG4108ESX Receptor VAPA_1c49470 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase VAPA_1c49540 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VAPA_1c49570 ENOG4105CD3 dihydroorotase VAPA_1c49580 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VAPA_1c49590 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c49620 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) VAPA_1c49740 ENOG4105D82 Glutamate dehydrogenase VAPA_1c49770 ENOG4105C26 Dehydrogenase VAPA_1c49780 ENOG4105EW9 transcriptional regulator AsnC family VAPA_1c49790 ENOG4105DFA alanine racemase domain protein VAPA_1c49800 ENOG4105CZX twitching motility protein VAPA_1c49810 ENOG4105CZX twitching motility protein VAPA_1c49820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VAPA_1c49840 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VAPA_1c49850 ENOG41082RQ UPF0102 protein VAPA_1c49860 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VAPA_1c49920 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) VAPA_1c50000 ENOG4108IG5 Transcriptional regulator VAPA_1c50010 ENOG4105C1P efflux transporter, rnd family, mfp subunit VAPA_1c50020 ENOG4105BZS acriflavin resistance protein VAPA_1c50030 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VAPA_1c50080 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) VAPA_1c50090 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) VAPA_1c50100 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) VAPA_1c50110 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) VAPA_1c50120 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) VAPA_1c50130 ENOG4108VQN 4-hydroxyphenylacetate 3-monooxygenase reductase VAPA_1c50140 ENOG4108R86 Transcriptional regulator VAPA_1c50230 ENOG4107RUE extracellular solute-binding protein family 1 VAPA_1c50240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_1c50250 ENOG4105F38 ABC transporter, permease VAPA_1c50260 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component VAPA_1c50320 ENOG4105K63 Thioredoxin VAPA_1c50330 ENOG4107QRT dEAD DEAH box helicase VAPA_1c50340 ENOG4107T0X DNA ligase VAPA_1c50350 ENOG4107T0X DNA ligase VAPA_1c50360 ENOG4108KSA LysR family transcriptional regulator VAPA_1c50370 ENOG4105CWN amidohydrolase VAPA_1c50410 ENOG4105E2Y ABC, transporter VAPA_1c50460 ENOG4105CIB oxidoreductase Domain protein VAPA_1c50470 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VAPA_1c50480 ENOG4105CNN ABC, transporter VAPA_1c50520 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) VAPA_1c50530 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) VAPA_1c50540 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) VAPA_1c50550 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) VAPA_1c50560 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VAPA_1c50570 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VAPA_1c50580 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VAPA_1c50590 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) VAPA_1c50610 ENOG4105F0I Aminotransferase VAPA_1c50620 ENOG4108Z43 UPF0250 protein VAPA_1c50630 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) VAPA_1c50640 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) VAPA_1c50650 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAPA_1c50670 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_1c50680 ENOG4105F4P )-transporter VAPA_1c50720 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein VAPA_1c50730 ENOG4105EB3 Histidine kinase VAPA_1c50740 ENOG4105E3W Two component transcriptional regulator (Winged helix family VAPA_1c50780 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) VAPA_1c50790 ENOG41080Z8 PHOSPHOCARRIER protein VAPA_1c50810 ENOG4105C2C drug resistance transporter, Bcr CflA VAPA_1c50830 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VAPA_1c50860 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal VAPA_1c50870 ENOG41084PQ 50s ribosomal protein l29 VAPA_1c50880 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) VAPA_1c50890 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) VAPA_1c50900 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) VAPA_1c50910 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) VAPA_1c50920 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity VAPA_1c50930 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) VAPA_1c50940 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) VAPA_1c50950 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) VAPA_1c50980 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) VAPA_1c50990 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VAPA_1c51000 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VAPA_1c51010 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) VAPA_1c51020 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) VAPA_1c51030 ENOG4105DZ1 carboxypeptidase VAPA_1c51040 ENOG4105DHZ alpha beta VAPA_1c51070 ENOG4108YXA Membrane VAPA_1c51080 ENOG4105D52 delta-aminolevulinic acid dehydratase VAPA_1c51090 ENOG4105D7N magnesium and cobalt transport protein CorA VAPA_1c51110 ENOG410642W LysR family Transcriptional regulator VAPA_1c51140 ENOG4105CYX Short-chain dehydrogenase reductase Sdr VAPA_1c51150 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein VAPA_1c51190 ENOG4108IV0 ABC, transporter VAPA_1c51200 ENOG4105C0Z ABC transporter VAPA_1c51220 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c51250 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR VAPA_1c51260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAPA_1c51290 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) VAPA_1c51300 ENOG4109066 lysm domain bon superfamily protein VAPA_1c51320 ENOG4105CH5 extracellular solute-binding protein, family 7 VAPA_1c51340 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c51340 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_1c51350 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) VAPA_1c51370 ENOG4105DC8 reductase VAPA_1c51380 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VAPA_1c51400 ENOG4105ECW sulfate abc transporter VAPA_1c51450 ENOG4105FYV Amp nucleosidase VAPA_1c51470 ENOG4108ZHR arsR family transcriptional regulator VAPA_1c51510 ENOG4105HEI LysR family (Transcriptional regulator VAPA_1c51540 ENOG4105CJ1 ABC, transporter VAPA_1c51560 ENOG4105K56 Transcriptional regulator VAPA_1c51570 ENOG4108ZHJ Organic hydroperoxide resistance protein VAPA_1c51590 ENOG4105E27 serine threonine protein kinase VAPA_1c51600 ENOG4107RSM transcriptional regulator VAPA_1c51610 ENOG4105CSU acyl-Coa dehydrogenase VAPA_1c51630 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_1c51660 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) VAPA_1c51670 ENOG4105C4Y ABC transporter VAPA_1c51680 ENOG4105CC0 LysR family Transcriptional regulator VAPA_1c51700 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VAPA_1c51720 ENOG4105DHQ Histidine kinase VAPA_1c51730 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_1c51750 ENOG4105FE9 pseudouridine synthase VAPA_1c51760 ENOG4108QBV Monogalactosyldiacylglycerol synthase VAPA_1c51800 ENOG4105EEX Two component transcriptional regulator (Winged helix family VAPA_1c51810 ENOG4105C08 Histidine kinase VAPA_1c51820 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) VAPA_1c51830 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) VAPA_1c51840 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) VAPA_1c51870 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VAPA_1c51920 ENOG410904N short-chain dehydrogenase reductase VAPA_1c51940 ENOG4105IJJ transcriptional regulator, crp fnr family VAPA_1c51950 ENOG4108IQE Amp-dependent synthetase and ligase VAPA_1c51960 ENOG4105C0Z ABC transporter VAPA_1c51970 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_1c52000 ENOG4108IV0 ABC, transporter VAPA_1c52030 ENOG4107R7Y intracellular protease Pfpi family VAPA_1c52090 ENOG4105DZG Dehydrogenase VAPA_1c52110 ENOG4105DZG Dehydrogenase VAPA_1c52120 ENOG4105E2R ROK family VAPA_1c52130 ENOG4105C2J ABC transporter VAPA_1c52140 ENOG4108HWW ABC transporter VAPA_1c52150 ENOG4105DFW ABC transporter VAPA_1c52170 ENOG4107RP9 extracellular solute-binding protein, family 3 VAPA_1c52180 ENOG4108M0I Transcriptional regulator VAPA_1c52210 ENOG4107RUY (E1 component), alpha subunit VAPA_1c52220 ENOG4105CPP Dehydrogenase, E1 component VAPA_1c52240 ENOG4105F6U Short-chain dehydrogenase reductase Sdr VAPA_1c52250 ENOG4105EJC lysr family transcriptional regulator VAPA_1c52280 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase VAPA_1c52310 ENOG4108UKI Enoyl-CoA hydratase VAPA_1c52320 ENOG4105C1G acyl-Coa dehydrogenase VAPA_1c52360 ENOG4108ZT0 50S ribosomal protein l17 VAPA_1c52370 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VAPA_1c52380 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) VAPA_1c52390 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) VAPA_1c52400 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits VAPA_1c52410 ENOG41067V7 50S ribosomal protein L36 VAPA_1c52420 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) VAPA_1c52430 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) VAPA_1c52440 ENOG4105VPB 50S ribosomal protein L30 VAPA_1c52450 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) VAPA_1c52460 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) VAPA_1c52470 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) VAPA_1c52480 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) VAPA_1c52490 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) VAPA_1c52500 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits VAPA_1c52510 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) VAPA_1c52520 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) VAPA_1c52540 ENOG4105II7 pyrroline-5-carboxylate reductase VAPA_1c52550 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) VAPA_1c52580 ENOG410829K Lysine exporter protein (Lyse ygga) VAPA_1c52590 ENOG4105CB5 ATP-dependent DNA helicase recG VAPA_1c52600 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) VAPA_1c52620 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) VAPA_1c52730 ENOG4105SKN orotidine 5''-phosphate decarboxylase VAPA_1c52760 ENOG41072GX Peptidase M22 Glycoprotease VAPA_1c52780 ENOG4105E98 transcriptional regulator DeoR family VAPA_1c52790 ENOG4107VIJ nudix hydrolase VAPA_1c52800 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family VAPA_1c52820 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VAPA_1c52830 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit VAPA_1c52840 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) VAPA_1c52870 ENOG4105C8V SAICAR synthetase VAPA_1c52880 ENOG4105D2N Aldolase VAPA_1c52890 ENOG4108ZRZ Transcriptional regulator (AsnC family) VAPA_1c52900 ENOG4105K6H D-cysteine desulfhydrase VAPA_1c52910 ENOG4105CA9 Pyruvate kinase VAPA_1c52920 ENOG4105BZA Phosphoglycerate kinase VAPA_1c52930 ENOG4105DUM transcriptional regulator, lysR family VAPA_1c52960 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase VAPA_1c53020 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) VAPA_1c53060 ENOG4105C79 DNA protecting protein DprA VAPA_1c53070 ENOG4108RPN Protein smg homolog VAPA_1c53090 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VAPA_1c53100 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VAPA_1c53130 ENOG4105F7P transcriptional regulator AsnC family VAPA_1c53140 ENOG4106PMH Extracellular solute-binding protein family 3 VAPA_1c53150 ENOG4105DRP amino acid AbC transporter VAPA_1c53160 ENOG4107SFI Major Facilitator superfamily VAPA_1c53180 ENOG4105CCU oxidase (Subunit III) VAPA_1c53200 ENOG4105BZ9 Cytochrome C oxidase, subunit I VAPA_1c53210 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) VAPA_1c53250 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component VAPA_1c53310 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) VAPA_1c53330 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) VAPA_1c53340 ENOG4105FB2 class II Aldolase VAPA_1c53350 ENOG4105G63 Type III effector Hrp-dependent VAPA_1c53360 ENOG4105EXW epimerase dehydratase VAPA_1c53370 ENOG4105ZXK Dehydrogenase VAPA_1c53380 ENOG4105CSP Major Facilitator Superfamily VAPA_1c53390 ENOG4105JXH GntR family transcriptional regulator VAPA_1c53400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) VAPA_1c53410 ENOG4108YXU transcriptional regulator AsnC family VAPA_1c53460 ENOG4108ZXC Two component transcriptional regulator, luxr family VAPA_1c53470 ENOG4105BZU Histidine kinase VAPA_1c53500 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) VAPA_1c53510 ENOG4105K6T rare lipoprotein A VAPA_1c53520 ENOG4105EUP HipA domain protein VAPA_1c53530 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) VAPA_1c53540 ENOG4108KPJ rna polymerase sigma factor VAPA_1c53570 ENOG4108U78 Glutathione S-transferase VAPA_1c53580 ENOG4107QTF adenylosuccinate lyase VAPA_1c53600 ENOG4105GAV receptor VAPA_1c53610 ENOG4108VWS Yaeq family VAPA_1c53640 ENOG4108ZCF integral membrane protein VAPA_1c53660 ENOG41086DT Membrane protein of unknown function VAPA_1c53670 ENOG4105ERG peptidase m48, ste24p VAPA_1c53680 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VAPA_1c53760 ENOG4105CWU Biogenesis protein VAPA_1c53790 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VAPA_1c53870 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VAPA_1c53880 ENOG4105J5G Transferase hexapeptide repeat containing protein VAPA_1c53890 ENOG4107R5Z Oxidoreductase domain protein VAPA_1c53900 ENOG4107QQG Dehydrogenase VAPA_1c53930 ENOG4105KHS type IV fimbrial pilin protein VAPA_1c53950 ENOG4105F8J Adenylate Guanylate cyclase VAPA_1c53960 ENOG4108UW8 fha domain-containing protein VAPA_1c53980 ENOG4108ZCF integral membrane protein VAPA_1c53990 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha VAPA_1c54000 ENOG4105CMV Succinyl-CoA synthetase subunit beta VAPA_1c54010 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase VAPA_1c54020 ENOG4108004 Modulates RecA activity (By similarity) VAPA_1c54030 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) VAPA_1c54060 ENOG4105DHQ Histidine kinase VAPA_1c54080 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase VAPA_1c54100 ENOG4105C9U ATP-dependent DNA helicase RecQ VAPA_1c54120 ENOG4105ETT transcriptional Regulator, LysR family VAPA_1c54180 ENOG4108SUT Major Facilitator Superfamily VAPA_1c54200 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) VAPA_1c54210 ENOG4105C1J atp-dependent rna helicase VAPA_1c54250 ENOG4108WYP Transcriptional regulator VAPA_1c54280 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) VAPA_1c54300 ENOG4105CP9 extracellular ligand-binding receptor VAPA_1c54310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VAPA_1c54330 ENOG4105CH2 amidohydrolase VAPA_1c54370 ENOG4105DRR Transcriptional regulator, GntR family VAPA_1c54410 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase VAPA_1c54420 ENOG4108JQ6 ABC transporter VAPA_1c54430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_1c54450 ENOG4105DEF Extracellular solute-binding protein, family 5 VAPA_1c54460 ENOG4105MP9 class II Aldolase VAPA_1c54470 ENOG4105EUB pirin domain protein VAPA_1c54500 ENOG41073TP transcriptional regulator VAPA_1c54520 ENOG4105E5Q amino acid AbC transporter VAPA_1c54530 ENOG4105F87 Dehydratase VAPA_1c54540 ENOG4105CM2 brancheD-chain amino acid aminotransferase VAPA_1c54560 ENOG4108YZY peptidylprolyl cis-trans isomerase VAPA_1c54580 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_1c54600 ENOG4105EUB pirin domain protein VAPA_1c54620 ENOG4105D4Y metalloprotease VAPA_1c54650 ENOG4105VRH Antibiotic biosynthesis monooxygenase VAPA_1c54680 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VAPA_1c54690 ENOG4105CV1 Transketolase (EC 2.2.1.1) VAPA_1c54700 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) VAPA_1c54710 ENOG4108S0S Nucleotidyl transferase VAPA_1c54720 ENOG4107RAQ aminopeptidase VAPA_1c54730 ENOG410642W LysR family Transcriptional regulator VAPA_1c54800 ENOG4105C6K Malic enzyme VAPA_1c54840 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) VAPA_1c54850 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) VAPA_1c54860 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) VAPA_1c54870 ENOG4105EHM Aminoglycoside phosphotransferase VAPA_1c54880 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) VAPA_1c54910 ENOG4105DXI Major Facilitator superfamily VAPA_1c54920 ENOG4105E5G Alpha beta hydrolase fold VAPA_1c54960 ENOG4105EYW Ion transport protein VAPA_1c54970 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein VAPA_1c54980 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VAPA_1c54990 ENOG4105DWV Homoserine O-trans-acetylase VAPA_1c55010 ENOG4105VFU Rna-binding protein VAPA_1c55020 ENOG4107FW0 short-chain dehydrogenase reductase VAPA_1c55040 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase VAPA_1c55050 ENOG4105C2X Arabinose 5-phosphate isomerase VAPA_1c55080 ENOG4105CSV Glutaminase VAPA_1c55090 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VAPA_1c55100 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins VAPA_1c55110 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) VAPA_1c55120 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) VAPA_2c00020 ENOG4105FA0 parb-like partition protein VAPA_2c00060 ENOG4108SXK Transporter Drug Metabolite Exporter family VAPA_2c00080 ENOG4108XM1 transcriptional regulator AsnC family VAPA_2c00160 ENOG4105E39 Enoyl-CoA hydratase VAPA_2c00190 ENOG4105EMY transcriptional regulator VAPA_2c00230 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein VAPA_2c00250 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein VAPA_2c00260 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_2c00280 ENOG4108IUZ ABC transporter VAPA_2c00290 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VAPA_2c00300 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_2c00450 ENOG4105E39 Enoyl-CoA hydratase VAPA_2c00460 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein VAPA_2c00490 ENOG4105EM2 membrane VAPA_2c00520 ENOG4105CHR reductase VAPA_2c00530 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) VAPA_2c00540 ENOG4105CXK mandelate racemase muconate lactonizing VAPA_2c00590 ENOG4108IV0 ABC, transporter VAPA_2c00600 ENOG4105CDA abc transporter atp-binding protein VAPA_2c00660 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_2c00670 ENOG4105M4H endoribonuclease L-psp VAPA_2c00690 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase VAPA_2c00710 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase VAPA_2c00730 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_2c00750 ENOG4105CMJ mandelate racemase muconate lactonizing VAPA_2c00760 ENOG4107YNJ LysR family Transcriptional regulator VAPA_2c00790 ENOG4107YPT transcriptional regulator VAPA_2c00860 ENOG4105EXG Transcriptional regulator VAPA_2c00890 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VAPA_2c00920 ENOG4107RGD Major Facilitator superfamily VAPA_2c00930 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) VAPA_2c00940 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) VAPA_2c00950 ENOG4105CE7 Amidase, hydantoinase carbamoylase family VAPA_2c00980 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) VAPA_2c01030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VAPA_2c01050 ENOG4108UKI Enoyl-CoA hydratase VAPA_2c01060 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_2c01100 ENOG410900P UPF0336 protein VAPA_2c01130 ENOG4107EXU Short-chain dehydrogenase reductase Sdr VAPA_2c01170 ENOG4108K01 transcriptional regulator VAPA_2c01220 ENOG4107QRS glycosyltransferase group 2 family protein VAPA_2c01240 ENOG4105CYM Glutathione S-transferase VAPA_2c01280 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) VAPA_2c01300 ENOG4105C5I Dehydrogenase VAPA_2c01340 ENOG4105KD7 acetyltransferase VAPA_2c01360 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_2c01370 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter VAPA_2c01380 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_2c01390 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate VAPA_2c01410 ENOG41073TP transcriptional regulator VAPA_2c01420 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAPA_2c01430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VAPA_2c01440 ENOG4107F9Y LysR family transcriptional regulator VAPA_2c01450 ENOG4105KHM amidohydrolase 2 VAPA_2c01530 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase VAPA_2c01610 ENOG4105CHR reductase VAPA_2c01620 ENOG4105CF7 AraC family transcriptional regulator VAPA_2c01630 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VAPA_2c01680 ENOG4105EE5 Membrane protein terC VAPA_2c01710 ENOG4105GAK amidohydrolase 2 VAPA_2c01730 ENOG4105ETE Transcriptional regulator (LacI family VAPA_2c01740 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_2c01750 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_2c01780 ENOG4108YYH Nadph-dependent fmn reductase VAPA_2c01810 ENOG4105ERH Fumarylacetoacetate hydrolase VAPA_2c01880 ENOG4105JSC dimethylmenaquinone methyltransferase VAPA_2c01960 ENOG4105D2S major facilitator superfamily VAPA_2c01970 ENOG4105BZU Histidine kinase VAPA_2c01980 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VAPA_2c01990 ENOG4105C26 Dehydrogenase VAPA_2c02090 ENOG4105CNA YD repeat protein VAPA_2c02120 ENOG4107TV1 YD repeat protein VAPA_2c02150 ENOG4105CNA YD repeat protein VAPA_2c02160 ENOG4105CS6 Rhs element vgr protein VAPA_2c02170 ENOG4105CMJ mandelate racemase muconate lactonizing VAPA_2c02180 ENOG4105CHR reductase VAPA_2c02200 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase VAPA_2c02210 ENOG4107YNJ LysR family Transcriptional regulator VAPA_2c02220 ENOG4107RSM transcriptional regulator VAPA_2c02250 ENOG4108R85 Short chain dehydrogenase VAPA_2c02290 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_2c02320 ENOG4105EBR Carboxylesterase VAPA_2c02440 ENOG4105DND Transcriptional regulator VAPA_2c02500 ENOG4105ETT transcriptional Regulator, LysR family VAPA_2c02540 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) VAPA_2c02550 ENOG4108Z6Z Transcriptional regulator VAPA_2c02560 ENOG4105C26 Dehydrogenase VAPA_2c02570 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAPA_2c02590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_2c02610 ENOG4108J59 Extracellular solute-binding protein, family 5 VAPA_2c02620 ENOG4105CJP fad dependent oxidoreductase VAPA_2c02650 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase VAPA_2c02670 ENOG4108RYR transcriptional regulator AsnC family VAPA_2c02750 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_2c02860 ENOG4108MP6 LysR family Transcriptional regulator VAPA_2c02890 ENOG4105CT1 (ABC) transporter VAPA_2c02900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAPA_2c02910 ENOG4108KWP DNA-binding transcriptional regulator GlcC VAPA_2c02930 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VAPA_2c02950 ENOG4105RQF LysR family Transcriptional regulator VAPA_2c02960 ENOG4108UQ8 endoribonuclease L-psp VAPA_2c02980 ENOG4105FDP GntR family transcriptional regulator VAPA_2c02990 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase VAPA_2c03010 ENOG4105C9Q fumarate hydratase class II VAPA_2c03030 ENOG4108UYU AsnC family transcriptional regulator VAPA_2c03060 ENOG4105GAK amidohydrolase 2 VAPA_2c03080 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_2c03090 ENOG4108JQ1 Dehydrogenase VAPA_2c03100 ENOG4105JSC dimethylmenaquinone methyltransferase VAPA_2c03170 ENOG4105CS6 Rhs element vgr protein VAPA_2c03280 ENOG4105CY0 Metallo-Beta-Lactamase VAPA_2c03290 ENOG4105BZU Histidine kinase VAPA_2c03300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAPA_2c03330 ENOG4108YV4 Universal stress protein VAPA_2c03340 ENOG4108YV4 Universal stress protein VAPA_2c03350 ENOG4105CD5 CoA-binding domain protein VAPA_2c03370 ENOG4105C0H protease VAPA_2c03390 ENOG41068KF Universal stress protein VAPA_2c03440 ENOG4105CHR reductase VAPA_2c03460 ENOG4105DBV ornithine carbamoyltransferase VAPA_2c03470 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VAPA_2c03510 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) VAPA_2c03520 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VAPA_2c03570 ENOG4108IQE Amp-dependent synthetase and ligase VAPA_2c03630 ENOG4108IV0 ABC, transporter VAPA_2c03640 ENOG4105C0Z ABC transporter VAPA_2c03660 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_2c03700 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_2c03740 ENOG4108WYP Transcriptional regulator VAPA_2c03750 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein VAPA_2c03760 ENOG4108IY8 ABC, transporter VAPA_2c03770 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component VAPA_2c03790 ENOG4105DHQ Histidine kinase VAPA_2c03800 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_2c03820 ENOG41080HT Transcriptional regulator, arsr family VAPA_2c03840 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) VAPA_2c03880 ENOG4105ENT Efflux transporter rnd family, mfp subunit VAPA_2c03890 ENOG4105D60 lipoprotein releasing system transmembrane protein VAPA_2c03900 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VAPA_2c03960 ENOG4105D0S secretion protein (HlyD VAPA_2c03970 ENOG4105CJ1 ABC, transporter VAPA_2c03980 ENOG4105CMI transporter VAPA_2c04050 ENOG4105VBA Cytochrome VAPA_2c04070 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit VAPA_2c04080 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAPA_2c04090 ENOG4105DHQ Histidine kinase VAPA_2c04110 ENOG4105DCG PHP domain protein VAPA_2c04120 ENOG4107QSN dihydrolipoamide acetyltransferase VAPA_2c04140 ENOG4107TTQ Alpha beta hydrolase fold VAPA_2c04150 ENOG4105CPP Dehydrogenase, E1 component VAPA_2c04160 ENOG4107R0V Pyruvate dehydrogenase VAPA_2c04320 ENOG4105CPQ Dehydrogenase VAPA_2c04360 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) VAPA_2c04400 ENOG4105VG1 fes assembly suf system protein VAPA_2c04470 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VAPA_2c04480 ENOG4105EA8 2-Nitropropane dioxygenase VAPA_2c04510 ENOG4105D0D Nitrate reductase 2, gamma subunit VAPA_2c04520 ENOG4105R3A Nitrate reductase VAPA_2c04530 ENOG4108IUE nitrate reductase beta subunit VAPA_2c04540 ENOG4105CRU nitrate reductase, alpha subunit VAPA_2c04570 ENOG4108JYZ YitT family VAPA_2c04620 ENOG4105DBV ornithine carbamoyltransferase VAPA_2c04630 ENOG4107R39 (ABC) transporter VAPA_2c04660 ENOG4105VN1 Heat shock protein VAPA_2c04730 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase VAPA_2c04760 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class VAPA_2c04770 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic VAPA_2c04810 ENOG4105K3G Periplasmic Protein VAPA_2c04820 ENOG4105CHU acetyl-coa acetyltransferase VAPA_2c04850 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VAPA_2c04860 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VAPA_2c04910 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VAPA_2c04950 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase VAPA_2c04960 ENOG4105DFG type I secretion outer membrane protein VAPA_2c05070 ENOG4105UYK outer membrane protein a VAPA_2c05080 ENOG4105EUR Domain-Containing protein VAPA_2c05090 ENOG4105EUR Domain-Containing protein VAPA_2c05140 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VAPA_2c05200 ENOG4105DIA mandelate racemase muconate lactonizing VAPA_2c05210 ENOG4105FDP GntR family transcriptional regulator VAPA_2c05270 ENOG4105I7M spermidine synthase VAPA_2c05320 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit VAPA_2c05330 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_2c05340 ENOG4108JPZ Monovalent cation H antiporter subunit D VAPA_2c05360 ENOG4107TDF Formate hydrogenlyase subunit 4 VAPA_2c05370 ENOG4108JPZ Monovalent cation H antiporter subunit D VAPA_2c05380 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) VAPA_2c05400 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_2c05410 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VAPA_2c05420 ENOG4108JPZ Monovalent cation H antiporter subunit D VAPA_2c05450 ENOG4108JPZ Monovalent cation H antiporter subunit D VAPA_2c05490 ENOG4105CXT aspartate transcarbamylase VAPA_2c05510 ENOG4105JN3 extra-cytoplasmic solute receptor family protein VAPA_2c05600 ENOG4105HEI LysR family (Transcriptional regulator VAPA_2c05630 ENOG4105CC9 acyl-Coa dehydrogenase VAPA_2c05640 ENOG4105D2B acyl-CoA dehydrogenase VAPA_2c05650 ENOG4105E39 Enoyl-CoA hydratase VAPA_2c05660 ENOG4105CD5 CoA-binding domain protein VAPA_2c05720 ENOG4105KVH Transcriptional regulator VAPA_2c05750 ENOG4105CF7 AraC family transcriptional regulator VAPA_2c05760 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit VAPA_2c05770 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding VAPA_2c05780 ENOG4105C7W Xanthine dehydrogenase VAPA_2c05790 ENOG4105C7F AcnD-accessory protein PrpF VAPA_2c05820 ENOG4105F04 LysR family Transcriptional regulator VAPA_2c05830 ENOG4105CK2 sodium dicarboxylate symporter VAPA_2c05840 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase VAPA_2c05870 ENOG4108M9J MaoC like domain protein VAPA_2c05900 ENOG41089UC methyltransferase, type 11 VAPA_2c05930 ENOG4105BZU Histidine kinase VAPA_2c05940 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAPA_2c06000 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein VAPA_2c06070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAPA_2c06080 ENOG4105US7 Histidine kinase VAPA_2c06130 ENOG4108JQ7 (ABC) transporter VAPA_2c06150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAPA_2c06160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAPA_2c06180 ENOG4108J59 Extracellular solute-binding protein, family 5 VAPA_2c06290 ENOG4107Y59 type iii secretion VAPA_2c06320 ENOG4108JIR Flagellum-specific ATP synthase VAPA_2c06340 ENOG4108TN6 type iii secretion VAPA_2c06520 ENOG4105CJ2 (LipO)protein VAPA_2c06530 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAPA_2c06540 ENOG4105CQZ Histidine kinase VAPA_2c06560 ENOG4105CHR reductase VAPA_2c06570 ENOG4105CHU acetyl-coa acetyltransferase VAPA_2c06590 ENOG4105EV9 Alpha Beta Hydrolase VAPA_2c06610 ENOG4105QJH Domain of unknown function (DUF718) VAPA_2c06620 ENOG4105CHR reductase VAPA_2c06630 ENOG4105DIA mandelate racemase muconate lactonizing VAPA_2c06660 ENOG4105CNN ABC, transporter VAPA_2c06740 ENOG4107YCY Transcriptional regulator VAPA_2c06770 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase VAPA_2c06800 ENOG4107HP6 Transcriptional regulator VAPA_2c06810 ENOG4105CEY Amp-dependent synthetase and ligase VAPA_2c06830 ENOG4105CGU Enoyl-CoA hydratase VAPA_2c06860 ENOG4105RQF LysR family Transcriptional regulator VAPA_2c06890 ENOG4105C26 Dehydrogenase VAPA_2c06900 ENOG4105NWF RbsD or FucU transport VAPA_2c06910 ENOG4108RVA ribokinase VAPA_2c06920 ENOG4105CNN ABC, transporter VAPA_2c06940 ENOG4105C2J ABC transporter VAPA_2c06980 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VAPA_2c07000 ENOG4108IV0 ABC, transporter VAPA_2c07010 ENOG4105C0Z ABC transporter VAPA_2c07040 ENOG4107EXU Short-chain dehydrogenase reductase Sdr VAPA_2c07050 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein VAPA_2c07110 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAPA_2c07130 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_2c07150 ENOG4105SKE transcriptional Regulator LysR family VAPA_2c07190 ENOG4105E3W Two component transcriptional regulator (Winged helix family VAPA_2c07200 ENOG4105EB3 Histidine kinase VAPA_2c07210 ENOG4105C1P efflux transporter, rnd family, mfp subunit VAPA_2c07220 ENOG4105BZS acriflavin resistance protein VAPA_2c07230 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VAPA_2c07280 ENOG4105DRP amino acid AbC transporter VAPA_2c07290 ENOG4108HW4 amino acid AbC transporter VAPA_2c07310 ENOG4105E7W lamb ycsf family protein VAPA_2c07330 ENOG4107R7A Allophanate hydrolase subunit 2 VAPA_2c07340 ENOG4105P4J Allophanate hydrolase, subunit 1 VAPA_2c07350 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VAPA_2c07360 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein VAPA_2c07380 ENOG4105CHM Aminotransferase VAPA_2c07390 ENOG4105JSC dimethylmenaquinone methyltransferase VAPA_2c07470 ENOG4105D5K Hemolysin activator protein VAPA_2c07550 ENOG4105CMQ Chloride channel VAPA_2c07570 ENOG41080XQ Signal transduction protein with cbs domains VAPA_2c07610 ENOG4108JUA Transcriptional regulator VAPA_2c07620 ENOG4105GAK amidohydrolase 2 VAPA_2c07660 ENOG4105W2Z cytochrome C, class I VAPA_2c07690 ENOG4105BZU Histidine kinase VAPA_2c07700 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_2c07710 ENOG4105IB0 filamentous hemagglutinin family outer membrane protein VAPA_2c07780 ENOG4105FCD Major Facilitator VAPA_2c07840 ENOG4105E18 UPF0276 protein VAPA_2c07860 ENOG4105D8V Glucose sorbosone dehydrogenase VAPA_2c07890 ENOG4105EP1 Efflux transporter rnd family, mfp subunit VAPA_2c07900 ENOG4108IJF Heavy metal efflux pump, CzcA VAPA_2c07920 ENOG4105WD1 Membrane VAPA_2c07970 ENOG4108ZCF integral membrane protein VAPA_2c08000 ENOG4105DRR Transcriptional regulator, GntR family VAPA_2c08090 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein VAPA_2c08110 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) VAPA_2c08120 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component VAPA_2c08160 ENOG4105R0I Feruloyl esterase VAPA_2c08250 ENOG41065RQ ADP-ribosylation crystallin J1 VAPA_2c08280 ENOG4107RH7 Nicotinate phosphoribosyltransferase VAPA_2c08360 ENOG4108KSA LysR family transcriptional regulator VAPA_2c08420 ENOG4105CHR reductase VAPA_2c08440 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein VAPA_2c08460 ENOG4105CPT Alpha beta hydrolase VAPA_2c08520 ENOG4105C5I Dehydrogenase VAPA_2c08530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VAPA_2c08570 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) VAPA_2c08610 ENOG4105DZG Dehydrogenase VAPA_2c08640 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) VAPA_2c08720 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_2c08730 ENOG4105WH1 Two component transcriptional regulator luxr family VAPA_2c08770 ENOG4105BZU Histidine kinase VAPA_2c08800 ENOG4105EQ2 LysR family Transcriptional regulator VAPA_2c08860 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VAPA_2c08870 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) VAPA_2c08900 ENOG4105CS1 NAD(P)H quinone oxidoreductase VAPA_2c08910 ENOG4105CC0 LysR family Transcriptional regulator VAPA_2c08950 ENOG41061N2 exported protein VAPA_2c08960 ENOG4105R1U AraC Family Transcriptional Regulator VAPA_2c08970 ENOG4105DJ2 Major Facilitator Superfamily VAPA_2c08980 ENOG4108K3A Glutathione S-transferase VAPA_2c09000 ENOG4105CS1 NAD(P)H quinone oxidoreductase VAPA_2c09040 ENOG4108K3A Glutathione S-transferase VAPA_2c09050 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VAPA_2c09110 ENOG4108YYC ycei family VAPA_2c09130 ENOG4105CH6 catalase VAPA_2c09140 ENOG4105HEI LysR family (Transcriptional regulator VAPA_2c09150 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr VAPA_2c09230 ENOG4105DZ2 Transcriptional regulator VAPA_2c09270 ENOG4105F2I Transposase VAPA_2c09320 ENOG4105CYM Glutathione S-transferase VAPA_2c09330 ENOG4108K3A Glutathione S-transferase VAPA_2c09340 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VAPA_2c09390 ENOG4105ENT Efflux transporter rnd family, mfp subunit VAPA_2c09410 ENOG4105BZS acriflavin resistance protein VAPA_2c09420 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VAPA_2c09430 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VAPA_2c09450 ENOG4105KWG Pfam:DUF1696 VAPA_2c09490 ENOG4108YXQ IS66 Orf2 family protein VAPA_2c09500 ENOG4105E5H Transposase VAPA_2c09540 ENOG4105D5K Hemolysin activator protein VAPA_2c09550 ENOG4105CKT filamentous hemagglutinin VAPA_2c09600 ENOG4105FDP GntR family transcriptional regulator VAPA_2c09610 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAPA_2c09620 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAPA_2c09640 ENOG4107HP6 Transcriptional regulator VAPA_2c09760 ENOG4105ENH Sulfatase VAPA_2c09840 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_2c09880 ENOG4105EXG Transcriptional regulator VAPA_2c09890 ENOG4108DN8 FAD dependent oxidoreductase VAPA_2c09940 ENOG4105CC0 LysR family Transcriptional regulator VAPA_2c09960 ENOG4105EWI Short-chain dehydrogenase reductase Sdr VAPA_2c09980 ENOG41062JF Transcriptional regulator VAPA_2c10000 ENOG4108R3E Dna-3-methyladenine glycosylase i VAPA_2c10030 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAPA_2c10130 ENOG4105EJC lysr family transcriptional regulator VAPA_2c10150 ENOG4105BZU Histidine kinase VAPA_2c10170 ENOG4108KXV response regulator VAPA_2c10180 ENOG4105UYK outer membrane protein a VAPA_2c10190 ENOG4105EUR Domain-Containing protein VAPA_2c10240 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_2c10310 ENOG4108KX4 response regulator VAPA_2c10340 ENOG4105GAK amidohydrolase 2 VAPA_2c10350 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr VAPA_2c10420 ENOG4108IV0 ABC, transporter VAPA_2c10430 ENOG4108IUZ ABC transporter VAPA_2c10470 ENOG4105C26 Dehydrogenase VAPA_2c10520 ENOG4108K2B transcriptional regulator VAPA_2c10610 ENOG4105EFZ amidohydrolase VAPA_2c10630 ENOG4105CHJ isochorismatase hydrolase VAPA_2c10650 ENOG4105EQ1 Transcriptional regulator VAPA_2c10690 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase VAPA_2c10710 ENOG4105ERH Fumarylacetoacetate hydrolase VAPA_2c10720 ENOG4105CQ2 DNA polymerase VAPA_2c10730 ENOG4105F04 LysR family Transcriptional regulator VAPA_2c10750 ENOG4105DG4 malate L-lactate dehydrogenase VAPA_2c10770 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAPA_2c10800 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VAPA_2c10820 ENOG4105GAK amidohydrolase 2 VAPA_2c10850 ENOG4107F9Y LysR family transcriptional regulator VAPA_2c10910 ENOG4105JAB phenazine biosynthesis protein, phzf family VAPA_2c10930 ENOG4107RZC phospholipase d VAPA_2c10990 ENOG4105BZU Histidine kinase VAPA_2c11080 ENOG4105CQB FAD linked oxidase domain protein VAPA_2c11090 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase VAPA_2c11110 ENOG4105KHC sulfurtransferase VAPA_2c11150 ENOG4105BZU Histidine kinase VAPA_2c11220 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAPA_2c11230 ENOG4105DUM transcriptional regulator, lysR family VAPA_2c11240 ENOG4108Z9W Outer membrane porin VAPA_2c11270 ENOG4105GAK amidohydrolase 2 VAPA_2c11310 ENOG4105FA0 parb-like partition protein VAPA_2c11350 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein VAPA_2c11380 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_2c11400 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) VAPA_2c11410 ENOG4108IV0 ABC, transporter VAPA_2c11450 ENOG4108IXY short-chain dehydrogenase reductase VAPA_2c11460 ENOG4105BZU Histidine kinase VAPA_2c11470 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAPA_2c11480 ENOG4105BZU Histidine kinase VAPA_2c11490 ENOG4105BZU Histidine kinase VAPA_2c11510 ENOG4108TXN phosphonate metabolism protein VAPA_2c11520 ENOG4108TXN phosphonate metabolism protein VAPA_2c11530 ENOG4105CMD Transcriptional regulator, GntR family VAPA_2c11540 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG VAPA_2c11570 ENOG4105FT8 Phosphonate metabolism VAPA_2c11580 ENOG4105ENV phosphonate C-P lyase system protein PhnK VAPA_2c11590 ENOG4105HRV phosphonate c-p lyase system protein phnl VAPA_2c11600 ENOG4105FD8 phosphonate metabolism protein PhnM VAPA_2c11610 ENOG4105D5T phosphonate abc transporter VAPA_2c11620 ENOG4105EHI Phosphonate ABC transporter, periplasmic VAPA_2c11720 ENOG4105EQ2 LysR family Transcriptional regulator VAPA_2c11740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_2c11750 ENOG4107RCV ABC transporter, permease VAPA_2c11760 ENOG4105CHM Aminotransferase VAPA_2c11800 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) VAPA_2c11830 ENOG4105DND Transcriptional regulator VAPA_2c11850 ENOG4105NN7 muconolactone delta-isomerase VAPA_2c11990 ENOG4105ENH Sulfatase VAPA_2c12000 ENOG4105E6M Sulphatase-modifying factor protein VAPA_2c12040 ENOG4105CQB FAD linked oxidase domain protein VAPA_2c12050 ENOG4105CGF Aromatic amino acid aminotransferase VAPA_2c12060 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) VAPA_2c12070 ENOG4105KME endoribonuclease L-psp VAPA_2c12080 ENOG4105VG5 Membrane VAPA_2c12110 ENOG4108Z9W Outer membrane porin VAPA_2c12230 ENOG4105C32 Amino acid ABC transporter (Permease) VAPA_2c12240 ENOG4105C0Z ABC transporter VAPA_2c12250 ENOG4108IV0 ABC, transporter VAPA_2c12270 ENOG4105CAF HipA N-terminal domain protein VAPA_2c12300 ENOG4108IV0 ABC, transporter VAPA_2c12310 ENOG4105C0Z ABC transporter VAPA_2c12320 ENOG4105CF8 branched-chain amino acid ABC transporter, permease VAPA_2c12330 ENOG4107R9N ABC transporter VAPA_2c12380 ENOG4105ES4 Nitrilase VAPA_2c12390 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VAPA_2c12410 ENOG4105CIS alcohol dehydrogenase VAPA_2c12420 ENOG4108IG5 Transcriptional regulator VAPA_2c12430 ENOG4107Y2X deaminase VAPA_2c12460 ENOG4105EN6 Membrane VAPA_2c12510 ENOG4105RQF LysR family Transcriptional regulator VAPA_2c12530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAPA_2c12540 ENOG4105F38 ABC transporter, permease VAPA_2c12550 ENOG4105D38 putrescine abc transporter VAPA_2c12590 ENOG4105DDR sarcosine oxidase (Beta subunit) VAPA_2c12600 ENOG4105M4H endoribonuclease L-psp VAPA_2c12610 ENOG41082A2 Alpha beta hydrolase VAPA_2c12620 ENOG4105EVD ribosomal RNA large subunit methyltransferase N VAPA_2c12660 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) VAPA_2c12670 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VAPA_2c12680 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) VAPA_2c12700 ENOG4105CAF HipA N-terminal domain protein VAPA_2c12730 ENOG4105YVM Phosphoesterase, PA-phosphatase related VAPA_2c12760 ENOG4105VDM plasmid maintenance system antidote protein, xre family VAPA_2c12810 ENOG4105F5W AtP-binding protein VAPA_2c12940 ENOG4105CDA abc transporter atp-binding protein VAPA_2c12970 ENOG4105GBT ABC transporter VAPA_2c13070 ENOG4105DFS Conserved Protein VAPA_2c13230 ENOG4108EHY type IV secretion system