locus-tag	class	description
VAPA_1c00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAPA_1c00020	COG0592	DNA-directed DNA polymerase activity
VAPA_1c00030	COG0187	DNA topoisomerase II activity
VAPA_1c00080	COG1408	metallophosphoesterase
VAPA_1c00100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VAPA_1c00110	COG0392	lysyltransferase activity
VAPA_1c00120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c00130	COG3568	Endonuclease Exonuclease Phosphatase
VAPA_1c00190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAPA_1c00230	COG4452	Inner membrane protein CreD
VAPA_1c00260	COG2205	protein histidine kinase activity
VAPA_1c00270	COG0745	RESPONSE REGULATOR receiver
VAPA_1c00300	COG2608	mercury ion transmembrane transporter activity
VAPA_1c00310	COG2217	Heavy metal translocating P-type atpase
VAPA_1c00320	COG0456	acetyltransferase
VAPA_1c00330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPA_1c00340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPA_1c00360	COG0745	RESPONSE REGULATOR receiver
VAPA_1c00370	COG0642	Histidine kinase
VAPA_1c00380	COG1902	pentaerythritol trinitrate reductase activity
VAPA_1c00400	COG1024	Enoyl-CoA hydratase
VAPA_1c00440	COG0445	tRNA wobble uridine modification
VAPA_1c00450	COG0357	Ribosomal RNA small subunit methyltransferase G
VAPA_1c00470	COG1192	Involved in chromosome partitioning
VAPA_1c00510	COG0277	FAD linked oxidase domain protein
VAPA_1c00530	COG2096	Adenosyltransferase
VAPA_1c00600	COG0583	DNA-binding transcription factor activity
VAPA_1c00640	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VAPA_1c00650	COG2894	cell division
VAPA_1c00660	COG0850	regulation of cytokinetic process
VAPA_1c00670	COG2233	PERMEase
VAPA_1c00680	COG2050	protein possibly involved in aromatic compounds catabolism
VAPA_1c00730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c00760	COG0477	Major facilitator Superfamily
VAPA_1c00790	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_1c00810	COG3246	L-lysine catabolic process to acetate
VAPA_1c00840	COG3284	Transcriptional regulator
VAPA_1c00940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAPA_1c01040	COG0492	ferredoxin-NADP+ reductase activity
VAPA_1c01070	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPA_1c01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c01090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c01130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAPA_1c01140	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPA_1c01170	COG0154	amidase activity
VAPA_1c01210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c01250	COG1950	PFAM Membrane protein of
VAPA_1c01260	COG0583	DNA-binding transcription factor activity
VAPA_1c01270	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c01280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c01320	COG1573	uracil-dna glycosylase
VAPA_1c01340	COG0804	urea catabolic process
VAPA_1c01380	COG3246	L-lysine catabolic process to acetate
VAPA_1c01390	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c01400	COG3485	protocatechuate 3,4-dioxygenase
VAPA_1c01440	COG0583	DNA-binding transcription factor activity
VAPA_1c01470	COG4548	von Willebrand factor, type A
VAPA_1c01490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAPA_1c01510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_1c01540	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c01560	COG0683	leucine binding
VAPA_1c01600	COG2066	Belongs to the glutaminase family
VAPA_1c01630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_1c01640	COG0700	Nucleoside recognition
VAPA_1c01650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c01670	COG0410	ABC transporter
VAPA_1c01710	COG0683	leucine binding
VAPA_1c01720	COG0633	Ferredoxin
VAPA_1c01800	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VAPA_1c01820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPA_1c01830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_1c01860	COG0514	ATP-dependent DNA helicase (RecQ)
VAPA_1c01880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c01910	COG2986	histidine ammonia-lyase
VAPA_1c01920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAPA_1c02000	COG1228	amidohydrolase
VAPA_1c02010	COG0402	S-adenosylhomocysteine deaminase activity
VAPA_1c02050	COG0583	DNA-binding transcription factor activity
VAPA_1c02070	COG0646	methionine synthase
VAPA_1c02070	COG1410	methionine synthase
VAPA_1c02120	COG1309	transcriptional regulator
VAPA_1c02200	COG0411	ABC transporter
VAPA_1c02220	COG1335	isochorismatase
VAPA_1c02240	COG2080	2 iron, 2 sulfur cluster binding
VAPA_1c02250	COG2010	Cytochrome c
VAPA_1c02250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_1c02360	COG3501	Rhs element vgr protein
VAPA_1c02510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_1c02510	COG0515	serine threonine protein kinase
VAPA_1c02530	COG4372	Transposase
VAPA_1c02540	COG3436	PFAM IS66 Orf2 family protein
VAPA_1c02650	COG3501	Rhs element vgr protein
VAPA_1c02760	COG0347	Belongs to the P(II) protein family
VAPA_1c02770	COG0004	ammonium transporteR
VAPA_1c02790	COG0583	DNA-binding transcription factor activity
VAPA_1c02800	COG0277	FAD linked oxidase domain protein
VAPA_1c02810	COG0277	FAD linked oxidase domain protein
VAPA_1c02820	COG0247	lactate metabolic process
VAPA_1c02840	COG0386	Belongs to the glutathione peroxidase family
VAPA_1c02860	COG0477	Major facilitator Superfamily
VAPA_1c02870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAPA_1c02890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_1c02920	COG0129	dihydroxy-acid dehydratase activity
VAPA_1c02940	COG3971	2-oxopent-4-enoate hydratase activity
VAPA_1c02960	COG3384	dioxygenase
VAPA_1c02970	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c02980	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_1c03000	COG1846	Transcriptional regulator
VAPA_1c03020	COG3209	COG3209 Rhs family protein
VAPA_1c03040	COG3501	Rhs element vgr protein
VAPA_1c03070	COG0583	DNA-binding transcription factor activity
VAPA_1c03090	COG1473	amidohydrolase
VAPA_1c03100	COG2974	May be involved in recombination
VAPA_1c03150	COG2205	protein histidine kinase activity
VAPA_1c03170	COG0579	oxidoreductase
VAPA_1c03200	COG2211	Major facilitator Superfamily
VAPA_1c03220	COG4974	Belongs to the 'phage' integrase family
VAPA_1c03250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c03260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c03320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_1c03330	COG1335	isochorismatase
VAPA_1c03390	COG0583	DNA-binding transcription factor activity
VAPA_1c03400	COG0708	Exodeoxyribonuclease III
VAPA_1c03410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAPA_1c03430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAPA_1c03440	COG0154	amidase activity
VAPA_1c03450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAPA_1c03460	COG1077	Cell shape determining protein MreB Mrl
VAPA_1c03490	COG0768	penicillin binding
VAPA_1c03510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAPA_1c03530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_1c03560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAPA_1c03630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAPA_1c03640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAPA_1c03650	COG0583	DNA-binding transcription factor activity
VAPA_1c03680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c03710	COG1177	transmembrane transport
VAPA_1c03720	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_1c03730	COG3842	ATPase activity
VAPA_1c03780	COG0028	Belongs to the TPP enzyme family
VAPA_1c03800	COG0730	response to heat
VAPA_1c03840	COG0724	RNA recognition motif
VAPA_1c03860	COG0023	Translation Initiation Factor
VAPA_1c03870	COG0513	Belongs to the DEAD box helicase family
VAPA_1c03880	COG0330	HflC and HflK could
VAPA_1c03890	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c03900	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c03930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPA_1c03960	COG2733	membrane
VAPA_1c03980	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_1c03990	COG1473	amidohydrolase
VAPA_1c04020	COG0243	molybdopterin cofactor binding
VAPA_1c04050	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c04060	COG1070	Carbohydrate kinase
VAPA_1c04070	COG1063	alcohol dehydrogenase
VAPA_1c04080	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c04100	COG1879	ABC-type sugar transport system periplasmic component
VAPA_1c04110	COG2207	Transcriptional regulator
VAPA_1c04120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c04210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_1c04230	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c04240	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAPA_1c04250	COG1946	Acyl-CoA thioesterase
VAPA_1c04270	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c04290	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c04300	COG4177	L-phenylalanine transmembrane transporter activity
VAPA_1c04320	COG0410	ABC transporter
VAPA_1c04330	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c04370	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c04380	COG0659	secondary active sulfate transmembrane transporter activity
VAPA_1c04430	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c04480	COG0667	Aldo Keto reductase
VAPA_1c04490	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c04500	COG1129	ABC transporter
VAPA_1c04520	COG1070	Carbohydrate kinase
VAPA_1c04530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAPA_1c04570	COG0629	single-stranded DNA binding
VAPA_1c04600	COG0217	transcriptional regulatory protein
VAPA_1c04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_1c04640	COG0482	sulfurtransferase activity
VAPA_1c04680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VAPA_1c04690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VAPA_1c04700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VAPA_1c04710	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c04720	COG0601	transmembrane transport
VAPA_1c04730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c04740	COG0444	Belongs to the ABC transporter superfamily
VAPA_1c04750	COG4608	Belongs to the ABC transporter superfamily
VAPA_1c04770	COG0747	negative chemotaxis
VAPA_1c04780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAPA_1c04810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAPA_1c04830	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
VAPA_1c04840	COG0735	belongs to the Fur family
VAPA_1c04850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_1c04900	COG1522	sequence-specific DNA binding
VAPA_1c04910	COG0058	SHG alpha-glucan phosphorylase activity
VAPA_1c04920	COG0297	glycogen (starch) synthase activity
VAPA_1c04930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAPA_1c04940	COG1523	belongs to the glycosyl hydrolase 13 family
VAPA_1c04950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPA_1c04960	COG0366	Alpha amylase catalytic
VAPA_1c04970	COG2072	flavoprotein involved in K transport
VAPA_1c05020	COG0495	leucyl-tRNA aminoacylation
VAPA_1c05050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAPA_1c05070	COG3158	transport of potassium into the cell
VAPA_1c05110	COG3135	benzoate transporter
VAPA_1c05120	COG0189	ligase activity
VAPA_1c05150	COG0121	glutamine amidotransferase
VAPA_1c05170	COG2814	Major facilitator Superfamily
VAPA_1c05200	COG0205	6-phosphofructokinase activity
VAPA_1c05220	COG1024	Enoyl-CoA hydratase
VAPA_1c05230	COG0183	Belongs to the thiolase family
VAPA_1c05250	COG0583	DNA-binding transcription factor activity
VAPA_1c05260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VAPA_1c05300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAPA_1c05320	COG1414	Transcriptional regulator
VAPA_1c05330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_1c05340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c05350	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c05410	COG0018	arginyl-trna synthetase
VAPA_1c05430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAPA_1c05440	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAPA_1c05450	COG1137	ATPase activity
VAPA_1c05460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VAPA_1c05470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c05590	COG0069	glutamate synthase activity
VAPA_1c05600	COG0653	protein targeting
VAPA_1c05650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAPA_1c05690	COG1335	isochorismatase
VAPA_1c05710	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VAPA_1c05740	COG2967	ApaG domain
VAPA_1c05750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAPA_1c05870	COG5002	protein histidine kinase activity
VAPA_1c05890	COG2205	protein histidine kinase activity
VAPA_1c05890	COG0784	Response regulator, receiver
VAPA_1c05890	COG2198	Histidine kinase
VAPA_1c05900	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VAPA_1c05910	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VAPA_1c05960	COG0515	serine threonine protein kinase
VAPA_1c06080	COG3501	Rhs element vgr protein
VAPA_1c06130	COG3501	Rhs element vgr protein
VAPA_1c06320	COG2072	flavoprotein involved in K transport
VAPA_1c06340	COG2144	transferase activity, transferring acyl groups
VAPA_1c06400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c06560	COG2129	metallophosphoesterase
VAPA_1c06590	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c06600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c06610	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
VAPA_1c06630	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c06640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c06660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_1c06670	COG2329	Antibiotic biosynthesis monooxygenase
VAPA_1c06680	COG0400	carboxylic ester hydrolase activity
VAPA_1c06720	COG0583	DNA-binding transcription factor activity
VAPA_1c06730	COG2853	Lipoprotein
VAPA_1c06790	COG0745	RESPONSE REGULATOR receiver
VAPA_1c06830	COG0583	DNA-binding transcription factor activity
VAPA_1c06840	COG1942	4-Oxalocrotonate Tautomerase
VAPA_1c06850	COG2267	carboxylic ester hydrolase activity
VAPA_1c06890	COG4214	carbohydrate transport
VAPA_1c06920	COG0583	DNA-binding transcription factor activity
VAPA_1c06970	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
VAPA_1c07060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_1c07080	COG3284	Transcriptional regulator
VAPA_1c07110	COG0165	Argininosuccinate lyase
VAPA_1c07140	COG3473	Maleate cis-trans isomerase
VAPA_1c07150	COG0583	DNA-binding transcription factor activity
VAPA_1c07210	COG0546	phosphoglycolate phosphatase activity
VAPA_1c07250	COG0512	Glutamine amidotransferase of anthranilate synthase
VAPA_1c07280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAPA_1c07290	COG0134	indole-3-glycerol-phosphate synthase activity
VAPA_1c07300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAPA_1c07340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAPA_1c07380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VAPA_1c07390	COG0081	regulation of translation
VAPA_1c07400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAPA_1c07410	COG0222	ribosome binding
VAPA_1c07420	COG0085	RNA polymerase activity
VAPA_1c07430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAPA_1c07470	COG5000	phosphorelay sensor kinase activity
VAPA_1c07480	COG2204	response regulator
VAPA_1c07540	COG0840	transmembrane signaling receptor activity
VAPA_1c07640	COG0154	amidase activity
VAPA_1c07670	COG0776	regulation of translation
VAPA_1c07680	COG0583	DNA-binding transcription factor activity
VAPA_1c07730	COG2205	protein histidine kinase activity
VAPA_1c07740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAPA_1c07770	COG0210	DNA helicase
VAPA_1c07780	COG0679	Auxin Efflux Carrier
VAPA_1c07810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAPA_1c07820	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAPA_1c07840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPA_1c07900	COG0583	DNA-binding transcription factor activity
VAPA_1c07910	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c07930	COG1215	transferase activity, transferring glycosyl groups
VAPA_1c07940	COG0726	polysaccharide deacetylase
VAPA_1c07940	COG1649	PFAM Uncharacterised BCR, COG1649
VAPA_1c08000	COG0038	chloride channel
VAPA_1c08030	COG0384	phenazine biosynthesis protein PhzF
VAPA_1c08040	COG0625	glutathione transferase activity
VAPA_1c08050	COG1280	lysine exporter protein (LysE YggA)
VAPA_1c08070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c08080	COG0697	spore germination
VAPA_1c08130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c08180	COG0457	Tetratricopeptide repeat
VAPA_1c08180	COG0463	Glycosyl transferase, family 2
VAPA_1c08240	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VAPA_1c08280	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VAPA_1c08280	COG0662	Cupin 2, conserved barrel domain protein
VAPA_1c08290	COG1216	Glycosyl transferase, family 2
VAPA_1c08290	COG0438	transferase activity, transferring glycosyl groups
VAPA_1c08300	COG1215	transferase activity, transferring glycosyl groups
VAPA_1c08320	COG2755	lipolytic protein G-D-S-L family
VAPA_1c08320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPA_1c08340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAPA_1c08350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAPA_1c08360	COG0438	transferase activity, transferring glycosyl groups
VAPA_1c08360	COG1216	Glycosyl transferase, family 2
VAPA_1c08370	COG1216	Glycosyl transferase, family 2
VAPA_1c08370	COG0438	transferase activity, transferring glycosyl groups
VAPA_1c08380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAPA_1c08430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPA_1c08440	COG2721	sulfolactate sulfo-lyase activity
VAPA_1c08450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_1c08470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c08480	COG2186	Transcriptional regulator
VAPA_1c08490	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c08500	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c08510	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_1c08520	COG2188	Transcriptional regulator
VAPA_1c08530	COG0683	leucine binding
VAPA_1c08570	COG0410	ABC transporter
VAPA_1c08590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPA_1c08600	COG0066	3-isopropylmalate dehydratase activity
VAPA_1c08680	COG0583	DNA-binding transcription factor activity
VAPA_1c08690	COG4221	oxidoreductase activity
VAPA_1c08710	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c08730	COG1024	Enoyl-CoA hydratase
VAPA_1c08730	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_1c08740	COG2852	Protein conserved in bacteria
VAPA_1c08750	COG0183	Belongs to the thiolase family
VAPA_1c08800	COG1024	Enoyl-CoA hydratase
VAPA_1c08810	COG0683	leucine binding
VAPA_1c08820	COG1607	acyl-coa hydrolase
VAPA_1c08830	COG5265	(ABC) transporter
VAPA_1c08840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_1c08850	COG0154	amidase activity
VAPA_1c08860	COG0583	DNA-binding transcription factor activity
VAPA_1c08870	COG1027	Aspartate ammonia-lyase
VAPA_1c08880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c08890	COG0765	amino acid transport
VAPA_1c08900	COG0765	amino acid transport
VAPA_1c08910	COG1126	abc transporter atp-binding protein
VAPA_1c08920	COG1957	nucleoside hydrolase
VAPA_1c08930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c08940	COG3344	reverse transcriptase
VAPA_1c08960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_1c08970	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c08980	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c09000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c09010	COG1024	Enoyl-CoA hydratase
VAPA_1c09020	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c09030	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c09040	COG0183	Belongs to the thiolase family
VAPA_1c09050	COG1024	Enoyl-CoA hydratase
VAPA_1c09050	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_1c09060	COG0583	DNA-binding transcription factor activity
VAPA_1c09080	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
VAPA_1c09110	COG0154	amidase activity
VAPA_1c09120	COG0444	Belongs to the ABC transporter superfamily
VAPA_1c09130	COG4608	Belongs to the ABC transporter superfamily
VAPA_1c09140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c09160	COG0747	negative chemotaxis
VAPA_1c09190	COG0418	dihydroorotase activity
VAPA_1c09220	COG0501	Belongs to the peptidase M48B family
VAPA_1c09240	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VAPA_1c09250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_1c09260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VAPA_1c09280	COG1846	Transcriptional regulator
VAPA_1c09310	COG1566	PFAM secretion protein HlyD family protein
VAPA_1c09330	COG2814	Major facilitator Superfamily
VAPA_1c09350	COG1187	pseudouridine synthase activity
VAPA_1c09360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPA_1c09370	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c09460	COG0656	L-ascorbic acid biosynthetic process
VAPA_1c09470	COG2814	Major facilitator Superfamily
VAPA_1c09520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAPA_1c09550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAPA_1c09560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAPA_1c09570	COG0523	cobalamin synthesis protein
VAPA_1c09590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VAPA_1c09610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAPA_1c09620	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VAPA_1c09630	COG2001	Belongs to the MraZ family
VAPA_1c09640	COG0275	rRNA processing
VAPA_1c09650	COG3116	cell division
VAPA_1c09670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPA_1c09680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAPA_1c09690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAPA_1c09700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAPA_1c09710	COG0772	Belongs to the SEDS family
VAPA_1c09720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAPA_1c09730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAPA_1c09740	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAPA_1c09750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAPA_1c09780	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAPA_1c09800	COG0583	DNA-binding transcription factor activity
VAPA_1c09820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAPA_1c09830	COG0575	Belongs to the CDS family
VAPA_1c09870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPA_1c09900	COG3150	esterase
VAPA_1c09910	COG2197	response regulator
VAPA_1c09930	COG0772	Belongs to the SEDS family
VAPA_1c09940	COG0312	modulator of DNA gyrase
VAPA_1c09960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAPA_1c09980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAPA_1c10000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPA_1c10010	COG0511	ligase activity, forming carbon-carbon bonds
VAPA_1c10020	COG0439	Biotin carboxylase
VAPA_1c10030	COG2264	protein methyltransferase activity
VAPA_1c10070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAPA_1c10080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAPA_1c10080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAPA_1c10140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAPA_1c10190	COG2204	response regulator
VAPA_1c10210	COG2205	protein histidine kinase activity
VAPA_1c10220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAPA_1c10250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_1c10280	COG0037	tRNA processing
VAPA_1c10300	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c10320	COG2175	clavaminate synthase activity
VAPA_1c10370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c10390	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VAPA_1c10400	COG3387	PFAM Glycoside hydrolase 15-related
VAPA_1c10420	COG0617	tRNA 3'-terminal CCA addition
VAPA_1c10440	COG0625	glutathione transferase activity
VAPA_1c10450	COG1285	pathogenesis
VAPA_1c10460	COG0741	lytic transglycosylase activity
VAPA_1c10470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAPA_1c10480	COG0583	DNA-binding transcription factor activity
VAPA_1c10540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_1c10580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAPA_1c10590	COG1522	sequence-specific DNA binding
VAPA_1c10600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VAPA_1c10670	COG0583	DNA-binding transcription factor activity
VAPA_1c10680	COG0477	Major facilitator Superfamily
VAPA_1c10800	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c10820	COG0583	DNA-binding transcription factor activity
VAPA_1c10840	COG2951	lytic endotransglycosylase activity
VAPA_1c10890	COG0697	spore germination
VAPA_1c10900	COG0583	DNA-binding transcription factor activity
VAPA_1c10930	COG3386	PFAM SMP-30 Gluconolaconase
VAPA_1c10940	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c10960	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c10970	COG1879	ABC-type sugar transport system periplasmic component
VAPA_1c10980	COG4213	ABC transporter substrate-binding protein
VAPA_1c11000	COG4214	carbohydrate transport
VAPA_1c11010	COG1129	ABC transporter
VAPA_1c11020	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c11030	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c11060	COG0583	DNA-binding transcription factor activity
VAPA_1c11070	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c11130	COG1132	(ABC) transporter
VAPA_1c11160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VAPA_1c11170	COG4178	(ABC) transporter
VAPA_1c11200	COG2271	Major facilitator Superfamily
VAPA_1c11370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPA_1c11400	COG1765	OsmC-like protein
VAPA_1c11410	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
VAPA_1c11430	COG0601	transmembrane transport
VAPA_1c11450	COG0747	negative chemotaxis
VAPA_1c11460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c11470	COG0444	Belongs to the ABC transporter superfamily
VAPA_1c11480	COG4608	Belongs to the ABC transporter superfamily
VAPA_1c11500	COG3385	transposase activity
VAPA_1c11510	COG3384	dioxygenase
VAPA_1c11520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAPA_1c11530	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPA_1c11550	COG3842	ATPase activity
VAPA_1c11580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAPA_1c11590	COG0166	Belongs to the GPI family
VAPA_1c11650	COG1175	transmembrane transport
VAPA_1c11660	COG0395	ABC-type sugar transport system, permease component
VAPA_1c11670	COG3842	ATPase activity
VAPA_1c11680	COG0246	Mannitol dehydrogenase
VAPA_1c11700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAPA_1c11720	COG2207	Transcriptional regulator
VAPA_1c11720	COG4753	response regulator
VAPA_1c11730	COG1070	Carbohydrate kinase
VAPA_1c11740	COG0459	protein refolding
VAPA_1c11750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAPA_1c11760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c11770	COG4774	siderophore transport
VAPA_1c11800	COG4772	TonB-dependent receptor
VAPA_1c11810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c11830	COG0765	amino acid transport
VAPA_1c11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c11860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAPA_1c11880	COG1560	Kdo2-lipid A biosynthetic process
VAPA_1c11900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VAPA_1c11920	COG1333	cytochrome c biogenesis protein
VAPA_1c11930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAPA_1c11940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VAPA_1c11950	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
VAPA_1c11960	COG0019	diaminopimelate decarboxylase activity
VAPA_1c11970	COG1965	Belongs to the frataxin family
VAPA_1c12040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAPA_1c12050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAPA_1c12060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAPA_1c12110	COG0067	glutamate synthase
VAPA_1c12110	COG0069	glutamate synthase activity
VAPA_1c12110	COG0070	glutamate synthase
VAPA_1c12130	COG1127	ABC transporter
VAPA_1c12140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAPA_1c12150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAPA_1c12160	COG2853	Lipoprotein
VAPA_1c12190	COG1131	(ABC) transporter
VAPA_1c12200	COG0842	Transport permease protein
VAPA_1c12210	COG5007	Belongs to the BolA IbaG family
VAPA_1c12220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAPA_1c12230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAPA_1c12260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_1c12270	COG0131	Imidazoleglycerol-phosphate dehydratase
VAPA_1c12290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAPA_1c12300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAPA_1c12320	COG1301	dicarboxylic acid transport
VAPA_1c12340	COG0107	imidazoleglycerol-phosphate synthase activity
VAPA_1c12350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAPA_1c12360	COG0140	phosphoribosyl-ATP diphosphatase activity
VAPA_1c12380	COG0537	adenosine 5'-monophosphoramidase activity
VAPA_1c12390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAPA_1c12400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAPA_1c12410	COG0805	protein transport
VAPA_1c12440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAPA_1c12450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAPA_1c12460	COG1970	mechanosensitive ion channel activity
VAPA_1c12480	COG1596	polysaccharide export
VAPA_1c12490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_1c12500	COG0489	protein tyrosine kinase activity
VAPA_1c12500	COG3206	protein involved in exopolysaccharide biosynthesis
VAPA_1c12560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_1c12590	COG0723	plastoquinol--plastocyanin reductase activity
VAPA_1c12600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAPA_1c12610	COG2857	Cytochrome c1
VAPA_1c12620	COG0625	glutathione transferase activity
VAPA_1c12630	COG2969	positive regulation of protein catabolic process
VAPA_1c12670	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c12680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAPA_1c12700	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAPA_1c12710	COG1136	(ABC) transporter
VAPA_1c12720	COG0740	serine-type endopeptidase activity
VAPA_1c12750	COG0601	transmembrane transport
VAPA_1c12810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPA_1c12820	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c12850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_1c12870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VAPA_1c12880	COG0463	Glycosyl transferase, family 2
VAPA_1c12890	COG0671	phosphoesterase, PA-phosphatase related
VAPA_1c12920	COG2030	dehydratase
VAPA_1c12920	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c12970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAPA_1c12980	COG2151	metal-sulfur cluster biosynthetic enzyme
VAPA_1c12990	COG3396	Phenylacetate-CoA oxygenase
VAPA_1c13000	COG3460	Phenylacetate-CoA oxygenase
VAPA_1c13010	COG3396	Phenylacetate-CoA oxygenase
VAPA_1c13030	COG2050	protein possibly involved in aromatic compounds catabolism
VAPA_1c13040	COG1024	Enoyl-CoA hydratase
VAPA_1c13060	COG1309	transcriptional regulator
VAPA_1c13070	COG2304	oxidoreductase activity
VAPA_1c13090	COG0714	Associated with various cellular activities
VAPA_1c13100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPA_1c13110	COG0084	hydrolase, TatD family'
VAPA_1c13140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VAPA_1c13150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAPA_1c13180	COG0583	DNA-binding transcription factor activity
VAPA_1c13220	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c13260	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAPA_1c13270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_1c13280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAPA_1c13330	COG1609	Transcriptional regulator
VAPA_1c13340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAPA_1c13360	COG0196	riboflavin kinase activity
VAPA_1c13410	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c13420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAPA_1c13460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAPA_1c13460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAPA_1c13480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAPA_1c13490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAPA_1c13500	COG0492	ferredoxin-NADP+ reductase activity
VAPA_1c13520	COG1674	ftsk spoiiie
VAPA_1c13530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAPA_1c13540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAPA_1c13550	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c13600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAPA_1c13600	COG0543	2 iron, 2 sulfur cluster binding
VAPA_1c13700	COG2816	NAD+ diphosphatase activity
VAPA_1c13710	COG0425	Belongs to the sulfur carrier protein TusA family
VAPA_1c13740	COG3022	response to hydroperoxide
VAPA_1c13760	COG2267	carboxylic ester hydrolase activity
VAPA_1c13770	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAPA_1c13770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAPA_1c13780	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c13810	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_1c13820	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c13840	COG2079	MmgE PrpD family protein
VAPA_1c13850	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c13870	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c13890	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c13950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAPA_1c14000	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c14010	COG0583	DNA-binding transcription factor activity
VAPA_1c14020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPA_1c14050	COG0477	Major facilitator Superfamily
VAPA_1c14060	COG1304	FMN binding
VAPA_1c14070	COG0583	DNA-binding transcription factor activity
VAPA_1c14120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c14130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c14140	COG1116	anion transmembrane transporter activity
VAPA_1c14140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c14150	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VAPA_1c14160	COG4221	oxidoreductase activity
VAPA_1c14170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c14180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_1c14210	COG0747	negative chemotaxis
VAPA_1c14220	COG0601	transmembrane transport
VAPA_1c14240	COG4172	Belongs to the ABC transporter superfamily
VAPA_1c14260	COG1473	amidohydrolase
VAPA_1c14270	COG2807	transmembrane transport
VAPA_1c14280	COG2186	Transcriptional regulator
VAPA_1c14310	COG1280	lysine exporter protein (LysE YggA)
VAPA_1c14350	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
VAPA_1c14390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAPA_1c14400	COG0569	domain protein
VAPA_1c14420	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VAPA_1c14530	COG0165	Argininosuccinate lyase
VAPA_1c14540	COG3275	phosphorelay sensor kinase activity
VAPA_1c14610	COG0583	DNA-binding transcription factor activity
VAPA_1c14640	COG3459	Glycosyltransferase 36 associated
VAPA_1c14660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAPA_1c14670	COG0181	hydroxymethylbilane synthase activity
VAPA_1c14710	COG1530	ribonuclease E activity
VAPA_1c14750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAPA_1c14750	COG0616	signal peptide processing
VAPA_1c14760	COG2223	nitrite transmembrane transporter activity
VAPA_1c14770	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAPA_1c14780	COG0424	maF-like protein
VAPA_1c14790	COG1399	metal-binding, possibly nucleic acid-binding protein
VAPA_1c14800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAPA_1c14810	COG0416	fatty acid biosynthetic process
VAPA_1c14820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAPA_1c14840	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c14850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPA_1c14860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPA_1c14910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPA_1c14920	COG0481	GTPase activity
VAPA_1c14930	COG0681	Belongs to the peptidase S26 family
VAPA_1c14950	COG0571	ribonuclease III activity
VAPA_1c14960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAPA_1c14970	COG1381	Involved in DNA repair and RecF pathway recombination
VAPA_1c14980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VAPA_1c14990	COG0736	holo-[acyl-carrier-protein] synthase activity
VAPA_1c15000	COG1472	Belongs to the glycosyl hydrolase 3 family
VAPA_1c15010	COG1451	nucleotide metabolic process
VAPA_1c15020	COG0443	Heat shock 70 kDa protein
VAPA_1c15030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAPA_1c15050	COG0762	integral membrane protein
VAPA_1c15060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAPA_1c15070	COG0159	tryptophan synthase activity
VAPA_1c15080	COG0133	tryptophan synthase activity
VAPA_1c15090	COG0135	phosphoribosylanthranilate isomerase activity
VAPA_1c15100	COG0101	tRNA pseudouridine synthase activity
VAPA_1c15120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAPA_1c15130	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_1c15140	COG0066	3-isopropylmalate dehydratase activity
VAPA_1c15150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPA_1c15180	COG0372	Belongs to the citrate synthase family
VAPA_1c15190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAPA_1c15200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAPA_1c15210	COG1053	succinate dehydrogenase
VAPA_1c15240	COG2188	Transcriptional regulator
VAPA_1c15250	COG0039	L-malate dehydrogenase activity
VAPA_1c15260	COG4106	trans-aconitate 2-methyltransferase activity
VAPA_1c15330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VAPA_1c15380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_1c15400	COG3483	tryptophan 2,3-dioxygenase activity
VAPA_1c15420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPA_1c15440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAPA_1c15450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAPA_1c15470	COG0268	Binds directly to 16S ribosomal RNA
VAPA_1c15480	COG0728	peptidoglycan biosynthetic process
VAPA_1c15510	COG3795	YCII-related domain
VAPA_1c15520	COG3795	YCII-related domain
VAPA_1c15530	COG4941	Belongs to the sigma-70 factor family
VAPA_1c15540	COG1917	Cupin 2, conserved barrel domain protein
VAPA_1c15540	COG4977	sequence-specific DNA binding
VAPA_1c15570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAPA_1c15580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAPA_1c15590	COG0617	tRNA 3'-terminal CCA addition
VAPA_1c15610	COG1392	Phosphate transport regulator
VAPA_1c15620	COG0306	phosphate transporter
VAPA_1c15650	COG0228	four-way junction DNA binding
VAPA_1c15660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAPA_1c15670	COG0336	Belongs to the RNA methyltransferase TrmD family
VAPA_1c15680	COG0335	large ribosomal subunit rRNA binding
VAPA_1c15700	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VAPA_1c15710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_1c15720	COG1162	GTPase activity
VAPA_1c15730	COG2154	pterin-4-alpha-carbinolamine dehydratase
VAPA_1c15740	COG0501	Belongs to the peptidase M48B family
VAPA_1c15750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAPA_1c15760	COG0513	Belongs to the DEAD box helicase family
VAPA_1c15770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAPA_1c15780	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_1c15790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAPA_1c15800	COG0604	alcohol dehydrogenase
VAPA_1c15850	COG4638	Rieske (2fe-2S)
VAPA_1c15900	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPA_1c15910	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c15920	COG0683	leucine binding
VAPA_1c15980	COG0411	ABC transporter
VAPA_1c16000	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c16010	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c16150	COG4964	Belongs to the GSP D family
VAPA_1c16260	COG2197	response regulator
VAPA_1c16300	COG0516	GMP reductase activity
VAPA_1c16310	COG3047	cAMP biosynthetic process
VAPA_1c16320	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VAPA_1c16330	COG0210	DNA helicase
VAPA_1c16350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAPA_1c16400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c16410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c16430	COG0412	Dienelactone hydrolase
VAPA_1c16460	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPA_1c16470	COG4608	Belongs to the ABC transporter superfamily
VAPA_1c16480	COG0444	Belongs to the ABC transporter superfamily
VAPA_1c16490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c16500	COG0601	transmembrane transport
VAPA_1c16510	COG4166	transmembrane transport
VAPA_1c16560	COG3064	Membrane
VAPA_1c16640	COG1722	exodeoxyribonuclease VII activity
VAPA_1c16650	COG0142	geranyltranstransferase activity
VAPA_1c16660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAPA_1c16670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAPA_1c16680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_1c16700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPA_1c16710	COG0477	Major facilitator Superfamily
VAPA_1c16720	COG1910	domain protein
VAPA_1c16750	COG2188	Transcriptional regulator
VAPA_1c16770	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c16840	COG1122	ATPase activity
VAPA_1c16940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
VAPA_1c16940	COG3608	succinylglutamate desuccinylase aspartoacylase
VAPA_1c16950	COG1320	monovalent cation:proton antiporter activity
VAPA_1c16960	COG2212	antiporter activity
VAPA_1c16980	COG0651	ATP synthesis coupled electron transport
VAPA_1c16990	COG1006	Multisubunit Na H antiporter MnhC subunit
VAPA_1c17000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAPA_1c17000	COG2111	Na H antiporter
VAPA_1c17010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAPA_1c17060	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAPA_1c17110	COG0287	Prephenate dehydrogenase
VAPA_1c17120	COG0077	Prephenate dehydratase
VAPA_1c17120	COG1605	Chorismate mutase
VAPA_1c17130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAPA_1c17170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAPA_1c17230	COG3772	lysozyme
VAPA_1c17290	COG3668	Plasmid stabilization system
VAPA_1c17300	COG4797	methyltransferase
VAPA_1c17300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAPA_1c17320	COG1187	pseudouridine synthase activity
VAPA_1c17370	COG1546	Belongs to the CinA family
VAPA_1c17370	COG1058	Belongs to the CinA family
VAPA_1c17400	COG3852	Histidine kinase
VAPA_1c17430	COG0708	Exodeoxyribonuclease III
VAPA_1c17470	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VAPA_1c17480	COG2205	protein histidine kinase activity
VAPA_1c17490	COG0392	lysyltransferase activity
VAPA_1c17530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAPA_1c17570	COG0277	FAD linked oxidase domain protein
VAPA_1c17590	COG1295	ribonuclease BN
VAPA_1c17610	COG3118	belongs to the thioredoxin family
VAPA_1c17630	COG0583	DNA-binding transcription factor activity
VAPA_1c17650	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c17660	COG2267	carboxylic ester hydrolase activity
VAPA_1c17710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAPA_1c17720	COG0583	DNA-binding transcription factor activity
VAPA_1c17820	COG3265	gluconokinase activity
VAPA_1c17830	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VAPA_1c17850	COG3070	regulator of competence-specific genes
VAPA_1c17870	COG0346	lactoylglutathione lyase activity
VAPA_1c17890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPA_1c17920	COG0625	glutathione transferase activity
VAPA_1c17950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAPA_1c17960	COG2719	SpoVR family
VAPA_1c17970	COG2718	Belongs to the UPF0229 family
VAPA_1c17980	COG2766	serine protein kinase
VAPA_1c18000	COG0484	heat shock protein binding
VAPA_1c18010	COG0443	Heat shock 70 kDa protein
VAPA_1c18020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAPA_1c18050	COG0688	phosphatidylethanolamine metabolic process
VAPA_1c18060	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c18070	COG2706	6-phosphogluconolactonase activity
VAPA_1c18090	COG2721	sulfolactate sulfo-lyase activity
VAPA_1c18100	COG2706	6-phosphogluconolactonase activity
VAPA_1c18130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c18140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_1c18150	COG2186	Transcriptional regulator
VAPA_1c18160	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c18170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_1c18190	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c18210	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c18250	COG0842	Transport permease protein
VAPA_1c18260	COG0842	Transport permease protein
VAPA_1c18270	COG1131	(ABC) transporter
VAPA_1c18280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_1c18300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c18320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAPA_1c18330	COG1802	Transcriptional regulator
VAPA_1c18370	COG0411	ABC transporter
VAPA_1c18390	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPA_1c18420	COG0583	DNA-binding transcription factor activity
VAPA_1c18430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_1c18440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c18480	COG2814	Major facilitator Superfamily
VAPA_1c18490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAPA_1c18500	COG0358	DNA primase activity
VAPA_1c18510	COG1295	ribonuclease BN
VAPA_1c18510	COG1959	2 iron, 2 sulfur cluster binding
VAPA_1c18540	COG0123	including yeast histone deacetylase and acetoin utilization protein
VAPA_1c18550	COG0824	Thioesterase
VAPA_1c18570	COG3237	CsbD-like
VAPA_1c18580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAPA_1c18600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_1c18610	COG1322	Protein conserved in bacteria
VAPA_1c18640	COG1611	Belongs to the LOG family
VAPA_1c18650	COG1024	Enoyl-CoA hydratase
VAPA_1c18660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAPA_1c18680	COG0322	excinuclease ABC activity
VAPA_1c18690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAPA_1c18710	COG0583	DNA-binding transcription factor activity
VAPA_1c18720	COG0596	Alpha beta hydrolase
VAPA_1c18730	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_1c18760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPA_1c18800	COG1881	PFAM PEBP family protein
VAPA_1c18840	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAPA_1c18850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAPA_1c18880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAPA_1c18890	COG0670	Belongs to the BI1 family
VAPA_1c18900	COG3193	protein, possibly involved in utilization of glycolate and propanediol
VAPA_1c18980	COG0450	alkyl hydroperoxide reductase
VAPA_1c19000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VAPA_1c19030	COG0360	Binds together with S18 to 16S ribosomal RNA
VAPA_1c19040	COG2965	DNA replication, synthesis of RNA primer
VAPA_1c19050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VAPA_1c19060	COG0359	binds to the 23S rRNA
VAPA_1c19070	COG0305	Participates in initiation and elongation during chromosome replication
VAPA_1c19100	COG1673	EVE domain
VAPA_1c19120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAPA_1c19130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAPA_1c19150	COG0436	Aminotransferase
VAPA_1c19170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAPA_1c19180	COG1763	Mo-molybdopterin cofactor biosynthetic process
VAPA_1c19190	COG0303	'Molybdopterin
VAPA_1c19200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAPA_1c19210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_1c19220	COG0314	molybdopterin synthase activity
VAPA_1c19230	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c19240	COG0542	response to heat
VAPA_1c19260	COG1022	Amp-dependent synthetase and ligase
VAPA_1c19270	COG0410	ABC transporter
VAPA_1c19320	COG1309	transcriptional regulator
VAPA_1c19330	COG0183	Belongs to the thiolase family
VAPA_1c19370	COG0583	DNA-binding transcription factor activity
VAPA_1c19400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPA_1c19410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPA_1c19440	COG2814	Major facilitator Superfamily
VAPA_1c19470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAPA_1c19480	COG3214	Protein conserved in bacteria
VAPA_1c19510	COG0673	inositol 2-dehydrogenase activity
VAPA_1c19540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c19550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c19570	COG1309	transcriptional regulator
VAPA_1c19580	COG0028	Belongs to the TPP enzyme family
VAPA_1c19650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VAPA_1c19660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VAPA_1c19670	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VAPA_1c19680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VAPA_1c19690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAPA_1c19700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPA_1c19700	COG0072	phenylalanine-tRNA ligase activity
VAPA_1c19710	COG0776	regulation of translation
VAPA_1c19810	COG1525	nuclease
VAPA_1c19850	COG0582	viral genome integration into host DNA
VAPA_1c19870	COG0640	Transcriptional regulator
VAPA_1c19910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_1c19940	COG0431	NADPH-dependent FMN reductase
VAPA_1c19960	COG2072	flavoprotein involved in K transport
VAPA_1c19970	COG2205	protein histidine kinase activity
VAPA_1c19980	COG0745	RESPONSE REGULATOR receiver
VAPA_1c20010	COG1136	(ABC) transporter
VAPA_1c20110	COG0701	Predicted permease
VAPA_1c20150	COG2186	Transcriptional regulator
VAPA_1c20160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VAPA_1c20170	COG1396	sequence-specific DNA binding
VAPA_1c20210	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c20250	COG3246	L-lysine catabolic process to acetate
VAPA_1c20260	COG2175	clavaminate synthase activity
VAPA_1c20280	COG2207	Transcriptional regulator
VAPA_1c20320	COG2175	clavaminate synthase activity
VAPA_1c20330	COG3246	L-lysine catabolic process to acetate
VAPA_1c20350	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c20360	COG3246	L-lysine catabolic process to acetate
VAPA_1c20450	COG1024	Enoyl-CoA hydratase
VAPA_1c20460	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_1c20460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAPA_1c20460	COG1042	CoA-binding domain protein
VAPA_1c20470	COG2079	MmgE PrpD family protein
VAPA_1c20480	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c20510	COG0596	Alpha beta hydrolase
VAPA_1c20540	COG1335	isochorismatase
VAPA_1c20610	COG1596	polysaccharide export
VAPA_1c20620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAPA_1c20680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAPA_1c20690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAPA_1c20690	COG0517	IMP dehydrogenase activity
VAPA_1c20700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAPA_1c20710	COG3206	protein involved in exopolysaccharide biosynthesis
VAPA_1c20710	COG0489	protein tyrosine kinase activity
VAPA_1c20720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_1c20730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_1c20760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_1c20780	COG1850	ribulose-bisphosphate carboxylase activity
VAPA_1c20800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_1c20810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c20820	COG1609	Transcriptional regulator
VAPA_1c20840	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c20850	COG2721	sulfolactate sulfo-lyase activity
VAPA_1c20900	COG0431	NADPH-dependent FMN reductase
VAPA_1c20930	COG0346	lactoylglutathione lyase activity
VAPA_1c20940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_1c20960	COG0798	PFAM Bile acid sodium symporter
VAPA_1c20990	COG2199	diguanylate cyclase activity
VAPA_1c20990	COG2200	EAL domain
VAPA_1c20990	COG3287	FIST C domain
VAPA_1c21000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAPA_1c21010	COG3300	MHYT domain
VAPA_1c21010	COG5001	Diguanylate cyclase
VAPA_1c21090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPA_1c21100	COG0366	Alpha amylase catalytic
VAPA_1c21110	COG0366	Alpha amylase catalytic
VAPA_1c21140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPA_1c21150	COG1640	4-alpha-glucanotransferase
VAPA_1c21260	COG2323	membrane
VAPA_1c21280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAPA_1c21290	COG1335	isochorismatase
VAPA_1c21350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c21370	COG3045	CreA protein
VAPA_1c21430	COG3243	poly(R)-hydroxyalkanoic acid synthase
VAPA_1c21440	COG0183	Belongs to the thiolase family
VAPA_1c21450	COG0583	DNA-binding transcription factor activity
VAPA_1c21470	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
VAPA_1c21520	COG1546	Belongs to the CinA family
VAPA_1c21520	COG1058	Belongs to the CinA family
VAPA_1c21530	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c21540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAPA_1c21540	COG4651	solute:proton antiporter activity
VAPA_1c21650	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c21670	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAPA_1c21680	COG0583	DNA-binding transcription factor activity
VAPA_1c21690	COG2197	response regulator
VAPA_1c21750	COG1522	sequence-specific DNA binding
VAPA_1c21760	COG0028	Belongs to the TPP enzyme family
VAPA_1c21810	COG1846	Transcriptional regulator
VAPA_1c21880	COG4670	ketone body catabolic process
VAPA_1c21890	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c21910	COG1609	Transcriptional regulator
VAPA_1c21930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_1c21940	COG1126	abc transporter atp-binding protein
VAPA_1c21970	COG2084	Dehydrogenase
VAPA_1c21980	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c21990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_1c22000	COG1063	alcohol dehydrogenase
VAPA_1c22010	COG1609	Transcriptional regulator
VAPA_1c22060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPA_1c22080	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VAPA_1c22130	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c22220	COG4221	oxidoreductase activity
VAPA_1c22230	COG0583	DNA-binding transcription factor activity
VAPA_1c22240	COG1917	Cupin 2, conserved barrel domain protein
VAPA_1c22240	COG4977	sequence-specific DNA binding
VAPA_1c22280	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VAPA_1c22290	COG1116	anion transmembrane transporter activity
VAPA_1c22300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c22310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c22320	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAPA_1c22420	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c22430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_1c22450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c22460	COG0765	amino acid transport
VAPA_1c22470	COG0765	amino acid transport
VAPA_1c22480	COG1126	abc transporter atp-binding protein
VAPA_1c22560	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c22570	COG4638	Rieske (2fe-2S)
VAPA_1c22600	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c22610	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c22620	COG0028	Belongs to the TPP enzyme family
VAPA_1c22640	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_1c22660	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c22670	COG3384	dioxygenase
VAPA_1c22680	COG3971	2-oxopent-4-enoate hydratase activity
VAPA_1c22730	COG0445	tRNA wobble uridine modification
VAPA_1c22740	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c22760	COG3039	Transposase
VAPA_1c22780	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c22840	COG1942	4-Oxalocrotonate Tautomerase
VAPA_1c22850	COG4569	acetaldehyde dehydrogenase (acetylating) activity
VAPA_1c22890	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c22940	COG1802	Transcriptional regulator
VAPA_1c22970	COG1703	isobutyryl-CoA mutase activity
VAPA_1c22980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPA_1c22990	COG0439	Biotin carboxylase
VAPA_1c23000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAPA_1c23040	COG1522	sequence-specific DNA binding
VAPA_1c23050	COG0697	spore germination
VAPA_1c23070	COG2878	Part of a membrane complex involved in electron transport
VAPA_1c23110	COG1959	2 iron, 2 sulfur cluster binding
VAPA_1c23120	COG1104	cysteine desulfurase activity
VAPA_1c23130	COG0822	iron-sulfur transferase activity
VAPA_1c23160	COG0443	Heat shock 70 kDa protein
VAPA_1c23170	COG0633	Ferredoxin
VAPA_1c23300	COG0579	oxidoreductase
VAPA_1c23330	COG0167	dihydroorotate dehydrogenase activity
VAPA_1c23340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VAPA_1c23370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAPA_1c23380	COG4566	intracellular signal transduction
VAPA_1c23400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAPA_1c23410	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAPA_1c23420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAPA_1c23430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAPA_1c23440	COG0791	NLP P60 protein
VAPA_1c23450	COG2133	pyrroloquinoline quinone binding
VAPA_1c23510	COG0567	Dehydrogenase, E1 component
VAPA_1c23520	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAPA_1c23530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAPA_1c23540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAPA_1c23580	COG1199	ATP-dependent helicase activity
VAPA_1c23600	COG0564	pseudouridine synthase activity
VAPA_1c23610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VAPA_1c23620	COG1187	pseudouridine synthase activity
VAPA_1c23630	COG0105	UTP biosynthetic process
VAPA_1c23640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VAPA_1c23670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAPA_1c23680	COG0124	histidyl-tRNA synthetase
VAPA_1c23710	COG1160	GTP binding
VAPA_1c23720	COG1923	regulation of RNA biosynthetic process
VAPA_1c23730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAPA_1c23740	COG0330	HflC and HflK could
VAPA_1c23750	COG0330	HflC and HflK could
VAPA_1c23770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
VAPA_1c23780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAPA_1c23830	COG0626	cystathionine gamma-synthase activity
VAPA_1c23860	COG1136	(ABC) transporter
VAPA_1c23880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAPA_1c23920	COG0667	Aldo Keto reductase
VAPA_1c23930	COG2059	Chromate
VAPA_1c23950	COG1295	ribonuclease BN
VAPA_1c23990	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c24090	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c24130	COG1024	Enoyl-CoA hydratase
VAPA_1c24200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c24210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c24220	COG0235	Class ii aldolase
VAPA_1c24240	COG2186	Transcriptional regulator
VAPA_1c24250	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c24260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_1c24350	COG3385	transposase activity
VAPA_1c24430	COG0625	glutathione transferase activity
VAPA_1c24440	COG0492	ferredoxin-NADP+ reductase activity
VAPA_1c24510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAPA_1c24520	COG0573	inorganic phosphate transmembrane transporter activity
VAPA_1c24530	COG0581	inorganic phosphate transmembrane transporter activity
VAPA_1c24540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAPA_1c24570	COG5002	protein histidine kinase activity
VAPA_1c24580	COG0534	Mate efflux family protein
VAPA_1c24600	COG0254	rRNA binding
VAPA_1c24610	COG0673	inositol 2-dehydrogenase activity
VAPA_1c24620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VAPA_1c24650	COG1074	ATP-dependent DNA helicase activity
VAPA_1c24670	COG1733	regulation of RNA biosynthetic process
VAPA_1c24690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VAPA_1c24700	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAPA_1c24710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAPA_1c24730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c24750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c24760	COG0741	lytic transglycosylase activity
VAPA_1c24760	COG1388	LysM domain
VAPA_1c24770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPA_1c24780	COG2226	methyltransferase
VAPA_1c24790	COG0328	RNA-DNA hybrid ribonuclease activity
VAPA_1c24800	COG0303	'Molybdopterin
VAPA_1c24810	COG0746	molybdenum cofactor guanylyltransferase activity
VAPA_1c24820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAPA_1c24830	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c24850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c24970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAPA_1c24990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_1c24990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAPA_1c25020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAPA_1c25070	COG0028	Belongs to the TPP enzyme family
VAPA_1c25080	COG0440	acetolactate synthase activity
VAPA_1c25100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAPA_1c25110	COG1183	phosphatidylcholine synthase activity
VAPA_1c25120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_1c25130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_1c25150	COG1414	Transcriptional regulator
VAPA_1c25160	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VAPA_1c25170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAPA_1c25230	COG1414	Transcriptional regulator
VAPA_1c25240	COG0745	RESPONSE REGULATOR receiver
VAPA_1c25250	COG0642	Histidine kinase
VAPA_1c25260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPA_1c25350	COG2022	thiamine diphosphate biosynthetic process
VAPA_1c25380	COG0351	phosphomethylpyrimidine kinase
VAPA_1c25420	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VAPA_1c25440	COG0492	ferredoxin-NADP+ reductase activity
VAPA_1c25450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VAPA_1c25460	COG2895	sulfate adenylyltransferase (ATP) activity
VAPA_1c25530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c25540	COG0601	transmembrane transport
VAPA_1c25560	COG4172	Belongs to the ABC transporter superfamily
VAPA_1c25570	COG1446	asparaginase
VAPA_1c25600	COG0789	Transcriptional regulator
VAPA_1c25620	COG0667	Aldo Keto reductase
VAPA_1c25630	COG0583	DNA-binding transcription factor activity
VAPA_1c25640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c25650	COG3588	fructose-bisphosphate aldolase
VAPA_1c25660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPA_1c25700	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAPA_1c25700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c25710	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VAPA_1c25730	COG0431	NADPH-dependent FMN reductase
VAPA_1c25750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c25770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_1c25780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c25790	COG1116	anion transmembrane transporter activity
VAPA_1c25820	COG1045	serine acetyltransferase
VAPA_1c25850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_1c25870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPA_1c25890	COG0450	alkyl hydroperoxide reductase
VAPA_1c25910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VAPA_1c25930	COG4208	sulfate ABC transporter
VAPA_1c25940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAPA_1c25950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VAPA_1c25970	COG3550	peptidyl-serine autophosphorylation
VAPA_1c26000	COG1196	nuclear chromosome segregation
VAPA_1c26020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAPA_1c26040	COG0242	peptide deformylase activity
VAPA_1c26060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c26070	COG4597	amino acid ABC transporter
VAPA_1c26080	COG0765	amino acid transport
VAPA_1c26110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAPA_1c26120	COG0024	Methionine aminopeptidase
VAPA_1c26130	COG0047	phosphoribosylformylglycinamidine synthase activity
VAPA_1c26130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAPA_1c26140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPA_1c26160	COG2917	probably involved in intracellular septation
VAPA_1c26170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPA_1c26180	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAPA_1c26200	COG2272	Belongs to the type-B carboxylesterase lipase family
VAPA_1c26210	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c26260	COG0411	ABC transporter
VAPA_1c26290	COG1024	Enoyl-CoA hydratase
VAPA_1c26290	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_1c26300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_1c26310	COG0183	Belongs to the thiolase family
VAPA_1c26320	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c26370	COG2130	NADP-dependent
VAPA_1c26380	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c26420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPA_1c26430	COG0667	Aldo Keto reductase
VAPA_1c26440	COG2814	Major facilitator Superfamily
VAPA_1c26450	COG0583	DNA-binding transcription factor activity
VAPA_1c26500	COG0277	FAD linked oxidase domain protein
VAPA_1c26500	COG0247	lactate metabolic process
VAPA_1c26530	COG0583	DNA-binding transcription factor activity
VAPA_1c26580	COG2814	Major facilitator Superfamily
VAPA_1c26590	COG2814	Major facilitator Superfamily
VAPA_1c26600	COG2995	paraquat-inducible protein a
VAPA_1c26610	COG2995	paraquat-inducible protein a
VAPA_1c26620	COG3008	intermembrane lipid transfer
VAPA_1c26620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAPA_1c26640	COG0477	Major facilitator Superfamily
VAPA_1c26680	COG0534	Mate efflux family protein
VAPA_1c26730	COG0246	Mannitol dehydrogenase
VAPA_1c26740	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_1c26770	COG0765	amino acid transport
VAPA_1c26780	COG1063	alcohol dehydrogenase
VAPA_1c26810	COG2186	Transcriptional regulator
VAPA_1c26820	COG2183	response to ionizing radiation
VAPA_1c26900	COG3501	Rhs element vgr protein
VAPA_1c26960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAPA_1c26970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAPA_1c27000	COG0084	hydrolase, TatD family'
VAPA_1c27010	COG0666	response to abiotic stimulus
VAPA_1c27040	COG0432	Pfam Uncharacterised protein family UPF0047
VAPA_1c27050	COG3360	Dodecin
VAPA_1c27060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAPA_1c27100	COG0515	serine threonine protein kinase
VAPA_1c27100	COG2815	serine threonine protein kinase
VAPA_1c27130	COG4968	Prepilin-type N-terminal cleavage methylation domain
VAPA_1c27220	COG0589	response to stress
VAPA_1c27260	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
VAPA_1c27280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAPA_1c27350	COG3278	Belongs to the heme-copper respiratory oxidase family
VAPA_1c27370	COG2217	Heavy metal translocating P-type atpase
VAPA_1c27390	COG2207	Transcriptional regulator
VAPA_1c27400	COG0667	Aldo Keto reductase
VAPA_1c27410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAPA_1c27470	COG1199	ATP-dependent helicase activity
VAPA_1c27480	COG2205	protein histidine kinase activity
VAPA_1c27480	COG5002	protein histidine kinase activity
VAPA_1c27480	COG0784	Response regulator, receiver
VAPA_1c27490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAPA_1c27560	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAPA_1c27570	COG0590	tRNA wobble adenosine to inosine editing
VAPA_1c27620	COG4566	intracellular signal transduction
VAPA_1c27630	COG4191	Histidine kinase
VAPA_1c27700	COG0523	cobalamin synthesis protein
VAPA_1c27800	COG0583	DNA-binding transcription factor activity
VAPA_1c27840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAPA_1c27900	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c27910	COG1733	regulation of RNA biosynthetic process
VAPA_1c27940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAPA_1c27940	COG0519	Catalyzes the synthesis of GMP from XMP
VAPA_1c27990	COG2914	Belongs to the UPF0125 (RnfH) family
VAPA_1c28000	COG2867	negative regulation of translational initiation
VAPA_1c28010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAPA_1c28080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAPA_1c28090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VAPA_1c28100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAPA_1c28110	COG0195	Participates in both transcription termination and antitermination
VAPA_1c28120	COG0779	Required for maturation of 30S ribosomal subunits
VAPA_1c28130	COG0477	Major facilitator Superfamily
VAPA_1c28140	COG4172	Belongs to the ABC transporter superfamily
VAPA_1c28150	COG4239	(ABC) transporter, permease
VAPA_1c28160	COG4174	ABC transporter (Permease)
VAPA_1c28170	COG4166	transmembrane transport
VAPA_1c28190	COG1793	dna ligase
VAPA_1c28200	COG1982	Orn Lys Arg decarboxylase major
VAPA_1c28290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAPA_1c28330	COG0583	DNA-binding transcription factor activity
VAPA_1c28340	COG0436	Aminotransferase
VAPA_1c28360	COG1643	Atp-dependent helicase
VAPA_1c28370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_1c28380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAPA_1c28380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAPA_1c28390	COG1280	lysine exporter protein (LysE YggA)
VAPA_1c28430	COG2171	N-acyltransferase activity
VAPA_1c28450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_1c28460	COG2890	protein-(glutamine-N5) methyltransferase activity
VAPA_1c28510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAPA_1c28530	COG2885	chlorophyll binding
VAPA_1c28540	COG0823	Involved in the tonB-independent uptake of proteins
VAPA_1c28550	COG1132	(ABC) transporter
VAPA_1c28560	COG1530	ribonuclease E activity
VAPA_1c28570	COG0424	maF-like protein
VAPA_1c28580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAPA_1c28590	COG0799	negative regulation of ribosome biogenesis
VAPA_1c28600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAPA_1c28610	COG0408	coproporphyrinogen oxidase activity
VAPA_1c28620	COG0151	Belongs to the GarS family
VAPA_1c28630	COG0217	transcriptional regulatory protein
VAPA_1c28640	COG2226	methyltransferase
VAPA_1c28750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAPA_1c28780	COG0433	COG0433 Predicted ATPase
VAPA_1c28800	COG1595	DNA-templated transcription, initiation
VAPA_1c28850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAPA_1c28860	COG1744	ABC transporter substrate-binding protein PnrA-like
VAPA_1c28920	COG0402	S-adenosylhomocysteine deaminase activity
VAPA_1c28930	COG2205	protein histidine kinase activity
VAPA_1c28940	COG0745	RESPONSE REGULATOR receiver
VAPA_1c28990	COG2925	Exonuclease
VAPA_1c29000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c29010	COG0542	response to heat
VAPA_1c29020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAPA_1c29070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VAPA_1c29080	COG1570	exodeoxyribonuclease VII activity
VAPA_1c29090	COG0811	peptide transport
VAPA_1c29100	COG0848	biopolymer transport protein
VAPA_1c29110	COG1663	tetraacyldisaccharide 4'-kinase activity
VAPA_1c29120	COG2835	tetraacyldisaccharide 4'-kinase activity
VAPA_1c29130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAPA_1c29140	COG0563	adenylate kinase activity
VAPA_1c29150	COG0252	asparaginase activity
VAPA_1c29160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VAPA_1c29180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_1c29190	COG2814	Major facilitator Superfamily
VAPA_1c29200	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_1c29210	COG1024	Enoyl-CoA hydratase
VAPA_1c29220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_1c29260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAPA_1c29280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_1c29290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VAPA_1c29300	COG1534	Rna-binding protein
VAPA_1c29330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAPA_1c29350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VAPA_1c29370	COG0505	Belongs to the CarA family
VAPA_1c29380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAPA_1c29390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VAPA_1c29400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_1c29410	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_1c29420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAPA_1c29430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_1c29460	COG0750	zinc metalloprotease
VAPA_1c29470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAPA_1c29500	COG0233	cytoplasmic translational termination
VAPA_1c29510	COG0528	UMP kinase activity
VAPA_1c29520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAPA_1c29530	COG0052	Belongs to the universal ribosomal protein uS2 family
VAPA_1c29550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c29560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VAPA_1c29560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VAPA_1c29570	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c29580	COG0557	exoribonuclease II activity
VAPA_1c29600	COG3339	Conserved Protein
VAPA_1c29630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAPA_1c29640	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
VAPA_1c29670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAPA_1c29690	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c29720	COG0745	RESPONSE REGULATOR receiver
VAPA_1c29730	COG2205	protein histidine kinase activity
VAPA_1c29740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAPA_1c29740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAPA_1c29750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAPA_1c29750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAPA_1c29760	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAPA_1c29770	COG0560	Phosphoserine phosphatase
VAPA_1c29810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c29820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAPA_1c29830	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c29860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAPA_1c29870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAPA_1c29880	COG1492	cobalamin metabolic process
VAPA_1c29890	COG1538	Outer membrane efflux protein
VAPA_1c29970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_1c29980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VAPA_1c29990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAPA_1c30000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAPA_1c30010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAPA_1c30040	COG1797	cobyrinic acid a,c-diamide synthase activity
VAPA_1c30080	COG0730	response to heat
VAPA_1c30100	COG4977	sequence-specific DNA binding
VAPA_1c30110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_1c30140	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c30170	COG1802	Transcriptional regulator
VAPA_1c30180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VAPA_1c30210	COG0583	DNA-binding transcription factor activity
VAPA_1c30220	COG0583	DNA-binding transcription factor activity
VAPA_1c30230	COG0129	dihydroxy-acid dehydratase activity
VAPA_1c30250	COG4654	Cytochrome c, class I
VAPA_1c30270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAPA_1c30290	COG0583	DNA-binding transcription factor activity
VAPA_1c30300	COG2910	NAD(P)H-binding
VAPA_1c30310	COG0114	fumarate hydratase activity
VAPA_1c30320	COG4175	Glycine betaine
VAPA_1c30330	COG4176	ABC-type proline glycine betaine transport system permease component
VAPA_1c30340	COG2113	Glycine betaine
VAPA_1c30430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAPA_1c30440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAPA_1c30450	COG0740	serine-type endopeptidase activity
VAPA_1c30460	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAPA_1c30490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_1c30520	COG1562	ergosterol biosynthetic process
VAPA_1c30530	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VAPA_1c30560	COG1011	Hydrolase
VAPA_1c30570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VAPA_1c30620	COG0410	ABC transporter
VAPA_1c30670	COG2204	response regulator
VAPA_1c30750	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c30770	COG0642	Histidine kinase
VAPA_1c30790	COG2326	polyphosphate kinase activity
VAPA_1c30850	COG3383	formate dehydrogenase (NAD+) activity
VAPA_1c30860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAPA_1c30880	COG0191	fructose-bisphosphate aldolase activity
VAPA_1c30890	COG0126	phosphoglycerate kinase activity
VAPA_1c30900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAPA_1c30910	COG3954	Phosphoribulokinase
VAPA_1c30920	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAPA_1c30960	COG0464	growth
VAPA_1c30980	COG1850	ribulose-bisphosphate carboxylase activity
VAPA_1c30990	COG0583	DNA-binding transcription factor activity
VAPA_1c31070	COG2010	Cytochrome c
VAPA_1c31130	COG0714	Associated with various cellular activities
VAPA_1c31190	COG0535	radical SAM domain protein
VAPA_1c31220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VAPA_1c31250	COG2197	response regulator
VAPA_1c31270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAPA_1c31270	COG0512	Glutamine amidotransferase of anthranilate synthase
VAPA_1c31300	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
VAPA_1c31310	COG1229	Formylmethanofuran dehydrogenase subunit A
VAPA_1c31410	COG3284	Transcriptional regulator
VAPA_1c31430	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
VAPA_1c31460	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
VAPA_1c31480	COG0702	epimerase
VAPA_1c31540	COG0527	aspartate kinase activity
VAPA_1c31550	COG0037	tRNA processing
VAPA_1c31560	COG0825	malonyl-CoA metabolic process
VAPA_1c31580	COG0215	cysteine-tRNA ligase activity
VAPA_1c31620	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_1c31670	COG0741	lytic transglycosylase activity
VAPA_1c31680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAPA_1c31690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAPA_1c31760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAPA_1c31760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAPA_1c31790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAPA_1c31800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAPA_1c31810	COG0436	Aminotransferase
VAPA_1c31820	COG0824	Thioesterase
VAPA_1c31840	COG0848	biopolymer transport protein
VAPA_1c31920	COG1741	Belongs to the pirin family
VAPA_1c31950	COG1741	Belongs to the pirin family
VAPA_1c31980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c31980	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAPA_1c31990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPA_1c32000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAPA_1c32020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_1c32060	COG0431	NADPH-dependent FMN reductase
VAPA_1c32060	COG3976	FMN-binding domain protein
VAPA_1c32060	COG1053	succinate dehydrogenase
VAPA_1c32080	COG0235	Class ii aldolase
VAPA_1c32180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VAPA_1c32200	COG0647	UMP catabolic process
VAPA_1c32210	COG1737	Transcriptional regulator
VAPA_1c32280	COG0410	ABC transporter
VAPA_1c32290	COG3842	ATPase activity
VAPA_1c32330	COG2205	protein histidine kinase activity
VAPA_1c32330	COG0784	Response regulator, receiver
VAPA_1c32330	COG2198	Histidine kinase
VAPA_1c32340	COG3437	response regulator, receiver
VAPA_1c32400	COG2207	Transcriptional regulator
VAPA_1c32440	COG0308	aminopeptidase N
VAPA_1c32520	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c32530	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
VAPA_1c32540	COG0028	Belongs to the TPP enzyme family
VAPA_1c32550	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c32560	COG1414	Transcriptional regulator
VAPA_1c32570	COG2267	carboxylic ester hydrolase activity
VAPA_1c32590	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c32600	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c32610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c32620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_1c32630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAPA_1c32650	COG4716	Myosin-crossreactive antigen
VAPA_1c32880	COG1596	polysaccharide export
VAPA_1c32890	COG0489	protein tyrosine kinase activity
VAPA_1c32890	COG3206	protein involved in exopolysaccharide biosynthesis
VAPA_1c32900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAPA_1c32910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_1c32970	COG0297	glycogen (starch) synthase activity
VAPA_1c32980	COG2197	response regulator
VAPA_1c33040	COG0587	DNA-directed DNA polymerase activity
VAPA_1c33050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAPA_1c33180	COG3384	dioxygenase
VAPA_1c33200	COG1132	(ABC) transporter
VAPA_1c33220	COG1309	transcriptional regulator
VAPA_1c33250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAPA_1c33270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_1c33280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
VAPA_1c33290	COG2080	2 iron, 2 sulfur cluster binding
VAPA_1c33320	COG1272	protein, Hemolysin III
VAPA_1c33340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAPA_1c33360	COG0640	Transcriptional regulator
VAPA_1c33380	COG1183	phosphatidylcholine synthase activity
VAPA_1c33390	COG0625	glutathione transferase activity
VAPA_1c33440	COG1360	Flagellar Motor Protein
VAPA_1c33500	COG2818	Glycosylase
VAPA_1c33520	COG2079	MmgE PrpD family protein
VAPA_1c33570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAPA_1c33580	COG0583	DNA-binding transcription factor activity
VAPA_1c33590	COG0583	DNA-binding transcription factor activity
VAPA_1c33630	COG1024	Enoyl-CoA hydratase
VAPA_1c33640	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c33690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c33740	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c33760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_1c33770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c33780	COG0583	DNA-binding transcription factor activity
VAPA_1c33820	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VAPA_1c33830	COG0545	Peptidyl-prolyl cis-trans isomerase
VAPA_1c33840	COG0531	amino acid
VAPA_1c33850	COG4303	Ethanolamine ammonia lyase large subunit
VAPA_1c33860	COG4302	ethanolamine ammonia-lyase activity
VAPA_1c33920	COG0671	phosphoesterase, PA-phosphatase related
VAPA_1c33940	COG0745	RESPONSE REGULATOR receiver
VAPA_1c33950	COG0642	Histidine kinase
VAPA_1c33960	COG0824	Thioesterase
VAPA_1c33970	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c34010	COG4336	lyase activity
VAPA_1c34030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_1c34040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c34080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAPA_1c34090	COG0509	glycine decarboxylation via glycine cleavage system
VAPA_1c34100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAPA_1c34100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAPA_1c34150	COG2084	Dehydrogenase
VAPA_1c34170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VAPA_1c34210	COG0477	Major facilitator Superfamily
VAPA_1c34240	COG2814	Major facilitator Superfamily
VAPA_1c34250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAPA_1c34260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAPA_1c34270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPA_1c34280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c34290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_1c34300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_1c34310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPA_1c34320	COG1414	Transcriptional regulator
VAPA_1c34340	COG0745	RESPONSE REGULATOR receiver
VAPA_1c34380	COG0583	DNA-binding transcription factor activity
VAPA_1c34410	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c34470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_1c34490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAPA_1c34520	COG0640	Transcriptional regulator
VAPA_1c34540	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_1c34550	COG2271	Major facilitator Superfamily
VAPA_1c34560	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c34610	COG1294	oxidase, subunit
VAPA_1c34620	COG1271	oxidase subunit
VAPA_1c34630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAPA_1c34640	COG4988	ABC transporter
VAPA_1c34670	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c34700	COG3264	Mechanosensitive ion channel
VAPA_1c34700	COG1511	domain protein
VAPA_1c34720	COG0714	Associated with various cellular activities
VAPA_1c34750	COG2951	lytic endotransglycosylase activity
VAPA_1c34810	COG1131	(ABC) transporter
VAPA_1c34880	COG0395	ABC-type sugar transport system, permease component
VAPA_1c34900	COG3842	ATPase activity
VAPA_1c34910	COG3842	ATPase activity
VAPA_1c34950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VAPA_1c34990	COG2308	Evidence 4 Homologs of previously reported genes of
VAPA_1c35030	COG1305	Transglutaminase-like
VAPA_1c35050	COG4585	Histidine kinase
VAPA_1c35060	COG2197	response regulator
VAPA_1c35110	COG0583	DNA-binding transcription factor activity
VAPA_1c35130	COG1024	Enoyl-CoA hydratase
VAPA_1c35160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c35190	COG1609	Transcriptional regulator
VAPA_1c35210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPA_1c35230	COG1126	abc transporter atp-binding protein
VAPA_1c35250	COG0765	amino acid transport
VAPA_1c35260	COG0765	amino acid transport
VAPA_1c35340	COG1196	nuclear chromosome segregation
VAPA_1c35340	COG0741	lytic transglycosylase activity
VAPA_1c35340	COG0739	heme binding
VAPA_1c35350	COG0187	DNA topoisomerase II activity
VAPA_1c35390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_1c35400	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VAPA_1c35410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VAPA_1c35440	COG2850	peptidyl-arginine hydroxylation
VAPA_1c35450	COG1047	Peptidyl-prolyl cis-trans
VAPA_1c35470	COG0756	dUTP diphosphatase activity
VAPA_1c35490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAPA_1c35500	COG0504	CTP synthase activity
VAPA_1c35510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAPA_1c35530	COG0148	phosphopyruvate hydratase activity
VAPA_1c35540	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAPA_1c35550	COG3201	nicotinamide mononucleotide transporter
VAPA_1c35580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAPA_1c35600	COG2833	Protein of unknown function (DUF455)
VAPA_1c35620	COG0183	Belongs to the thiolase family
VAPA_1c35640	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c35650	COG4974	Belongs to the 'phage' integrase family
VAPA_1c35660	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c35680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAPA_1c35690	COG0802	atpase or kinase
VAPA_1c35700	COG0860	N-Acetylmuramoyl-L-alanine amidase
VAPA_1c35720	COG0586	Pfam SNARE associated Golgi protein
VAPA_1c35740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAPA_1c35760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAPA_1c35770	COG4181	ATPase activity
VAPA_1c35800	COG5285	phytanoyl-CoA dioxygenase
VAPA_1c35820	COG3795	YCII-related domain
VAPA_1c35830	COG4941	Belongs to the sigma-70 factor family
VAPA_1c35920	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c35980	COG1566	PFAM secretion protein HlyD family protein
VAPA_1c36000	COG1846	Transcriptional regulator
VAPA_1c36010	COG1132	(ABC) transporter
VAPA_1c36050	COG1007	ATP synthesis coupled electron transport
VAPA_1c36080	COG0713	ATP synthesis coupled electron transport
VAPA_1c36100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_1c36110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VAPA_1c36120	COG1034	ATP synthesis coupled electron transport
VAPA_1c36150	COG0649	NAD binding
VAPA_1c36160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_1c36170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_1c36180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_1c36210	COG0149	triose-phosphate isomerase activity
VAPA_1c36230	COG1185	polyribonucleotide nucleotidyltransferase activity
VAPA_1c36240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAPA_1c36260	COG0683	leucine binding
VAPA_1c36290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAPA_1c36300	COG3707	response regulator
VAPA_1c36310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c36320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c36330	COG1116	anion transmembrane transporter activity
VAPA_1c36350	COG2223	nitrite transmembrane transporter activity
VAPA_1c36360	COG0515	serine threonine protein kinase
VAPA_1c36360	COG2815	serine threonine protein kinase
VAPA_1c36370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAPA_1c36390	COG0243	molybdopterin cofactor binding
VAPA_1c36400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAPA_1c36440	COG3842	ATPase activity
VAPA_1c36460	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_1c36470	COG3833	ABC-type maltose transport systems, permease component
VAPA_1c36490	COG0791	NLP P60 protein
VAPA_1c36500	COG2081	HI0933 family
VAPA_1c36510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VAPA_1c36520	COG1610	YqeY-like protein
VAPA_1c36530	COG0494	nUDIX hydrolase
VAPA_1c36600	COG1672	PFAM Archaeal ATPase
VAPA_1c36600	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPA_1c36630	COG0405	Gamma-glutamyltransferase
VAPA_1c36640	COG0583	DNA-binding transcription factor activity
VAPA_1c36670	COG0312	modulator of DNA gyrase
VAPA_1c36680	COG3028	Belongs to the UPF0307 family
VAPA_1c36690	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAPA_1c36770	COG0475	glutathione-regulated potassium exporter activity
VAPA_1c36810	COG0789	Transcriptional regulator
VAPA_1c36820	COG1045	serine acetyltransferase
VAPA_1c36850	COG1289	transmembrane transporter activity
VAPA_1c36870	COG1522	sequence-specific DNA binding
VAPA_1c36890	COG2311	Membrane
VAPA_1c36900	COG0583	DNA-binding transcription factor activity
VAPA_1c36920	COG1846	Transcriptional regulator
VAPA_1c36950	COG3119	arylsulfatase activity
VAPA_1c37000	COG1858	cytochrome C peroxidase
VAPA_1c37040	COG2375	cellular response to nickel ion
VAPA_1c37050	COG0598	Magnesium transport protein CorA
VAPA_1c37070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VAPA_1c37150	COG0601	transmembrane transport
VAPA_1c37160	COG0747	negative chemotaxis
VAPA_1c37220	COG1968	undecaprenyl-diphosphatase activity
VAPA_1c37240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c37250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPA_1c37260	COG1737	Transcriptional regulator
VAPA_1c37280	COG1538	Outer membrane efflux protein
VAPA_1c37290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_1c37300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_1c37310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_1c37340	COG2972	Histidine kinase
VAPA_1c37370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPA_1c37410	COG0004	ammonium transporteR
VAPA_1c37420	COG3279	Response regulator of the LytR AlgR family
VAPA_1c37470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VAPA_1c37510	COG0789	Transcriptional regulator
VAPA_1c37530	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c37540	COG2201	protein-glutamate methylesterase activity
VAPA_1c37550	COG2918	glutathione biosynthetic process
VAPA_1c37590	COG0523	cobalamin synthesis protein
VAPA_1c37620	COG0477	Major facilitator Superfamily
VAPA_1c37670	COG2354	Protein conserved in bacteria
VAPA_1c37700	COG4628	conserved protein (DUF2132)
VAPA_1c37730	COG0564	pseudouridine synthase activity
VAPA_1c37770	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
VAPA_1c37780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPA_1c37790	COG1252	NADH dehydrogenase
VAPA_1c37820	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c37830	COG1764	response to oxidative stress
VAPA_1c37870	COG0765	amino acid transport
VAPA_1c37880	COG0765	amino acid transport
VAPA_1c37910	COG0583	DNA-binding transcription factor activity
VAPA_1c37950	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_1c37990	COG3191	aminopeptidase activity
VAPA_1c38010	COG0789	Transcriptional regulator
VAPA_1c38030	COG0488	(ABC) transporter
VAPA_1c38040	COG0513	Belongs to the DEAD box helicase family
VAPA_1c38080	COG3842	ATPase activity
VAPA_1c38100	COG1175	transmembrane transport
VAPA_1c38120	COG2186	Transcriptional regulator
VAPA_1c38130	COG0129	dihydroxy-acid dehydratase activity
VAPA_1c38140	COG3734	2-keto-3-deoxy-galactonokinase
VAPA_1c38150	COG0800	Aldolase
VAPA_1c38160	COG0235	Class ii aldolase
VAPA_1c38180	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c38240	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPA_1c38260	COG3842	ATPase activity
VAPA_1c38280	COG0346	lactoylglutathione lyase activity
VAPA_1c38300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPA_1c38320	COG0800	Aldolase
VAPA_1c38370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAPA_1c38380	COG0259	pyridoxamine-phosphate oxidase activity
VAPA_1c38410	COG0679	Auxin Efflux Carrier
VAPA_1c38440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPA_1c38450	COG1309	transcriptional regulator
VAPA_1c38460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAPA_1c38510	COG2169	Transcriptional regulator
VAPA_1c38530	COG0697	spore germination
VAPA_1c38570	COG0625	glutathione transferase activity
VAPA_1c38630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAPA_1c38660	COG4774	siderophore transport
VAPA_1c38820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_1c38870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPA_1c38920	COG0285	dihydrofolate synthase activity
VAPA_1c38930	COG1393	Belongs to the ArsC family
VAPA_1c38950	COG3123	guanosine phosphorylase activity
VAPA_1c38960	COG0137	argininosuccinate synthase activity
VAPA_1c38980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAPA_1c38990	COG1666	GTP binding
VAPA_1c39010	COG0251	oxidation-reduction process
VAPA_1c39020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VAPA_1c39030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAPA_1c39040	COG0667	Aldo Keto reductase
VAPA_1c39080	COG1464	Belongs to the NlpA lipoprotein family
VAPA_1c39090	COG2011	ABC-type metal ion transport system permease component
VAPA_1c39100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAPA_1c39110	COG1464	Belongs to the NlpA lipoprotein family
VAPA_1c39120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAPA_1c39130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPA_1c39140	COG0308	aminopeptidase N
VAPA_1c39150	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAPA_1c39210	COG2080	2 iron, 2 sulfur cluster binding
VAPA_1c39220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
VAPA_1c39230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_1c39240	COG3386	PFAM SMP-30 Gluconolaconase
VAPA_1c39250	COG3302	dmso reductase anchor subunit
VAPA_1c39260	COG0437	4 iron, 4 sulfur cluster binding
VAPA_1c39270	COG0243	molybdopterin cofactor binding
VAPA_1c39280	COG0583	DNA-binding transcription factor activity
VAPA_1c39310	COG2721	sulfolactate sulfo-lyase activity
VAPA_1c39320	COG2721	sulfolactate sulfo-lyase activity
VAPA_1c39330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_1c39340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPA_1c39350	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c39360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAPA_1c39380	COG1414	Transcriptional regulator
VAPA_1c39430	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c39440	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c39470	COG1414	Transcriptional regulator
VAPA_1c39480	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
VAPA_1c39490	COG0477	Major facilitator Superfamily
VAPA_1c39500	COG2771	luxR family
VAPA_1c39540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_1c39540	COG2010	Cytochrome c
VAPA_1c39550	COG0583	DNA-binding transcription factor activity
VAPA_1c39560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c39580	COG4521	taurine ABC transporter
VAPA_1c39600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c39650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c39660	COG0444	Belongs to the ABC transporter superfamily
VAPA_1c39670	COG4608	Belongs to the ABC transporter superfamily
VAPA_1c39680	COG1228	amidohydrolase
VAPA_1c39740	COG1253	flavin adenine dinucleotide binding
VAPA_1c39750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VAPA_1c39780	COG3501	Rhs element vgr protein
VAPA_1c39820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c39840	COG1116	anion transmembrane transporter activity
VAPA_1c39850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c39860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c39880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_1c39900	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c39910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_1c39950	COG0513	Belongs to the DEAD box helicase family
VAPA_1c39960	COG2321	neutral zinc metallopeptidase
VAPA_1c39970	COG0717	Belongs to the dCTP deaminase family
VAPA_1c39980	COG0402	S-adenosylhomocysteine deaminase activity
VAPA_1c40010	COG0583	DNA-binding transcription factor activity
VAPA_1c40030	COG2366	antibiotic biosynthetic process
VAPA_1c40040	COG4977	sequence-specific DNA binding
VAPA_1c40050	COG0583	DNA-binding transcription factor activity
VAPA_1c40060	COG2814	Major facilitator Superfamily
VAPA_1c40070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAPA_1c40080	COG4654	Cytochrome c, class I
VAPA_1c40100	COG0604	alcohol dehydrogenase
VAPA_1c40170	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c40180	COG2301	Belongs to the HpcH HpaI aldolase family
VAPA_1c40190	COG0583	DNA-binding transcription factor activity
VAPA_1c40240	COG2252	PERMEase
VAPA_1c40260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_1c40300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAPA_1c40330	COG3344	reverse transcriptase
VAPA_1c40380	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c40510	COG2186	Transcriptional regulator
VAPA_1c40540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_1c40550	COG1802	Transcriptional regulator
VAPA_1c40570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_1c40580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_1c40590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c40630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_1c40650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c40690	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c40710	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c40730	COG1953	Uracil, thiamine, allantoin
VAPA_1c40770	COG1309	transcriptional regulator
VAPA_1c40800	COG2233	PERMEase
VAPA_1c40810	COG0656	L-ascorbic acid biosynthetic process
VAPA_1c40830	COG4566	intracellular signal transduction
VAPA_1c40840	COG0477	Major facilitator Superfamily
VAPA_1c40870	COG1301	dicarboxylic acid transport
VAPA_1c40890	COG0628	permease
VAPA_1c40920	COG0583	DNA-binding transcription factor activity
VAPA_1c40930	COG3960	tartronate-semialdehyde synthase activity
VAPA_1c40940	COG3622	Belongs to the hyi family
VAPA_1c40950	COG2084	Dehydrogenase
VAPA_1c40970	COG0281	malic enzyme
VAPA_1c40970	COG0280	phosphate acetyltransferase
VAPA_1c40980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_1c41010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_1c41030	COG1116	anion transmembrane transporter activity
VAPA_1c41040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c41120	COG1733	regulation of RNA biosynthetic process
VAPA_1c41150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c41180	COG0590	tRNA wobble adenosine to inosine editing
VAPA_1c41190	COG0829	nickel cation binding
VAPA_1c41200	COG0583	DNA-binding transcription factor activity
VAPA_1c41210	COG2084	Dehydrogenase
VAPA_1c41230	COG0583	DNA-binding transcription factor activity
VAPA_1c41320	COG2879	small protein
VAPA_1c41330	COG1966	Carbon starvation protein
VAPA_1c41360	COG0791	NLP P60 protein
VAPA_1c41480	COG0667	Aldo Keto reductase
VAPA_1c41490	COG3540	Alkaline phosphatase
VAPA_1c41500	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_1c41510	COG0395	ABC-type sugar transport system, permease component
VAPA_1c41520	COG1175	transmembrane transport
VAPA_1c41550	COG2390	Transcriptional regulator
VAPA_1c41560	COG2814	Major facilitator Superfamily
VAPA_1c41600	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c41620	COG0477	Major facilitator Superfamily
VAPA_1c41680	COG0613	PHP domain protein
VAPA_1c41700	COG0009	L-threonylcarbamoyladenylate synthase
VAPA_1c41710	COG1994	Peptidase M50
VAPA_1c41720	COG0180	Tryptophanyl-tRNA synthetase
VAPA_1c41730	COG2197	response regulator
VAPA_1c41760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VAPA_1c41770	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VAPA_1c41780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPA_1c41790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAPA_1c41800	COG1047	Peptidyl-prolyl cis-trans
VAPA_1c41810	COG2003	Belongs to the UPF0758 family
VAPA_1c41820	COG2840	Smr protein MutS2
VAPA_1c41850	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAPA_1c41870	COG0765	amino acid transport
VAPA_1c41880	COG0765	amino acid transport
VAPA_1c41900	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
VAPA_1c41910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPA_1c41920	COG0477	Major facilitator Superfamily
VAPA_1c41930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAPA_1c41940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPA_1c41950	COG1845	cytochrome c oxidase, subunit III
VAPA_1c41960	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VAPA_1c41990	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
VAPA_1c42000	COG1272	protein, Hemolysin III
VAPA_1c42020	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c42040	COG0583	DNA-binding transcription factor activity
VAPA_1c42050	COG0477	Major facilitator Superfamily
VAPA_1c42060	COG0583	DNA-binding transcription factor activity
VAPA_1c42080	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VAPA_1c42090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAPA_1c42130	COG0437	4 iron, 4 sulfur cluster binding
VAPA_1c42140	COG3383	formate dehydrogenase (NAD+) activity
VAPA_1c42140	COG0243	molybdopterin cofactor binding
VAPA_1c42210	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAPA_1c42220	COG4149	molybdate abc transporter
VAPA_1c42240	COG3383	formate dehydrogenase (NAD+) activity
VAPA_1c42260	COG0583	DNA-binding transcription factor activity
VAPA_1c42270	COG0489	protein tyrosine kinase activity
VAPA_1c42320	COG3132	Protein of unknown function, DUF480
VAPA_1c42330	COG3698	Phosphodiester glycosidase
VAPA_1c42340	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_1c42350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPA_1c42350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPA_1c42410	COG0659	secondary active sulfate transmembrane transporter activity
VAPA_1c42430	COG3293	Transposase
VAPA_1c42470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAPA_1c42480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VAPA_1c42490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAPA_1c42500	COG0602	queuosine metabolic process
VAPA_1c42520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAPA_1c42540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAPA_1c42550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VAPA_1c42570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAPA_1c42580	COG0588	phosphoglycerate mutase activity
VAPA_1c42590	COG0793	Belongs to the peptidase S41A family
VAPA_1c42600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAPA_1c42610	COG2982	Protein involved in outer membrane biogenesis
VAPA_1c42630	COG2197	response regulator
VAPA_1c42640	COG4585	Histidine kinase
VAPA_1c42700	COG2823	Periplasmic or secreted lipoprotein
VAPA_1c42750	COG3568	Endonuclease Exonuclease Phosphatase
VAPA_1c42760	COG0494	nUDIX hydrolase
VAPA_1c42770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAPA_1c42800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAPA_1c42810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAPA_1c42840	COG2226	methyltransferase
VAPA_1c42880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_1c42900	COG1175	transmembrane transport
VAPA_1c42910	COG0395	ABC-type sugar transport system, permease component
VAPA_1c42920	COG3842	ATPase activity
VAPA_1c42930	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_1c42940	COG1511	domain protein
VAPA_1c42940	COG3264	Mechanosensitive ion channel
VAPA_1c42960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VAPA_1c43010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPA_1c43010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAPA_1c43060	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAPA_1c43070	COG0745	RESPONSE REGULATOR receiver
VAPA_1c43100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAPA_1c43110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAPA_1c43210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAPA_1c43220	COG1334	flagellar protein FlaG
VAPA_1c43260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VAPA_1c43270	COG1317	bacterial-type flagellum organization
VAPA_1c43290	COG2882	bacterial-type flagellum organization
VAPA_1c43310	COG1580	Controls the rotational direction of flagella during chemotaxis
VAPA_1c43350	COG1338	Plays a role in the flagellum-specific transport system
VAPA_1c43360	COG1987	bacterial-type flagellum assembly
VAPA_1c43390	COG1256	bacterial-type flagellum assembly
VAPA_1c43400	COG0840	transmembrane signaling receptor activity
VAPA_1c43420	COG0835	chemotaxis
VAPA_1c43430	COG0840	transmembrane signaling receptor activity
VAPA_1c43440	COG0840	transmembrane signaling receptor activity
VAPA_1c43450	COG0840	transmembrane signaling receptor activity
VAPA_1c43470	COG0835	chemotaxis
VAPA_1c43480	COG3951	Flagellar rod assembly protein muramidase FlgJ
VAPA_1c43480	COG1705	Flagellar rod assembly protein muramidase FlgJ
VAPA_1c43500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAPA_1c43510	COG4786	Flagellar basal body rod
VAPA_1c43520	COG4787	bacterial-type flagellum-dependent cell motility
VAPA_1c43530	COG1749	Flagellar hook protein flgE
VAPA_1c43540	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VAPA_1c43550	COG1558	bacterial-type flagellum-dependent cell motility
VAPA_1c43560	COG1815	bacterial-type flagellum-dependent cell motility
VAPA_1c43620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAPA_1c43630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAPA_1c43640	COG2890	protein-(glutamine-N5) methyltransferase activity
VAPA_1c43650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAPA_1c43670	COG1253	flavin adenine dinucleotide binding
VAPA_1c43680	COG0741	lytic transglycosylase activity
VAPA_1c43690	COG0442	prolyl-tRNA aminoacylation
VAPA_1c43700	COG0494	nUDIX hydrolase
VAPA_1c43720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAPA_1c43730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAPA_1c43740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAPA_1c43750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAPA_1c43760	COG0142	geranyltranstransferase activity
VAPA_1c43800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VAPA_1c43820	COG1696	Membrane protein involved in D-alanine export
VAPA_1c43840	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAPA_1c43850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VAPA_1c43860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPA_1c43860	COG2755	lipolytic protein G-D-S-L family
VAPA_1c43870	COG0494	nUDIX hydrolase
VAPA_1c43890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
VAPA_1c43900	COG0653	protein targeting
VAPA_1c43930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAPA_1c43940	COG0583	DNA-binding transcription factor activity
VAPA_1c43980	COG2205	protein histidine kinase activity
VAPA_1c43980	COG5002	protein histidine kinase activity
VAPA_1c43980	COG0784	Response regulator, receiver
VAPA_1c43990	COG0831	urea catabolic process
VAPA_1c44010	COG0832	Belongs to the urease beta subunit family
VAPA_1c44020	COG0804	urea catabolic process
VAPA_1c44050	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VAPA_1c44060	COG0830	nickel cation binding
VAPA_1c44070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VAPA_1c44140	COG0745	RESPONSE REGULATOR receiver
VAPA_1c44180	COG2205	protein histidine kinase activity
VAPA_1c44190	COG0745	RESPONSE REGULATOR receiver
VAPA_1c44210	COG2982	Protein involved in outer membrane biogenesis
VAPA_1c44270	COG1538	Outer membrane efflux protein
VAPA_1c44320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c44850	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VAPA_1c44880	COG0582	viral genome integration into host DNA
VAPA_1c44900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAPA_1c44910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAPA_1c44940	COG0515	serine threonine protein kinase
VAPA_1c44940	COG2815	serine threonine protein kinase
VAPA_1c44950	COG1561	YicC-like family, N-terminal region
VAPA_1c44960	COG0194	GDP metabolic process
VAPA_1c44970	COG1758	RNA polymerase activity
VAPA_1c44980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAPA_1c45010	COG0529	Catalyzes the synthesis of activated sulfate
VAPA_1c45040	COG1420	regulation of RNA biosynthetic process
VAPA_1c45050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAPA_1c45060	COG0497	DNA recombination
VAPA_1c45070	COG1660	Displays ATPase and GTPase activities
VAPA_1c45090	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VAPA_1c45100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAPA_1c45130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAPA_1c45150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAPA_1c45160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAPA_1c45170	COG0193	aminoacyl-tRNA hydrolase activity
VAPA_1c45190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAPA_1c45210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c45230	COG4608	Belongs to the ABC transporter superfamily
VAPA_1c45240	COG0747	negative chemotaxis
VAPA_1c45250	COG0747	negative chemotaxis
VAPA_1c45260	COG0154	amidase activity
VAPA_1c45300	COG0583	DNA-binding transcription factor activity
VAPA_1c45330	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPA_1c45360	COG2267	carboxylic ester hydrolase activity
VAPA_1c45370	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VAPA_1c45380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAPA_1c45390	COG1984	allophanate hydrolase subunit 2
VAPA_1c45400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VAPA_1c45410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAPA_1c45420	COG0742	ribosomal rna small subunit methyltransferase
VAPA_1c45450	COG0612	Peptidase, M16
VAPA_1c45460	COG0612	Peptidase, M16
VAPA_1c45500	COG2197	response regulator
VAPA_1c45520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAPA_1c45530	COG4335	DNA alkylation repair
VAPA_1c45540	COG1999	signal sequence binding
VAPA_1c45550	COG0109	protoheme IX farnesyltransferase activity
VAPA_1c45620	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VAPA_1c45640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPA_1c45670	COG2226	methyltransferase
VAPA_1c45680	COG1040	competence protein
VAPA_1c45690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAPA_1c45710	COG0489	protein tyrosine kinase activity
VAPA_1c45750	COG1024	Enoyl-CoA hydratase
VAPA_1c45760	COG1022	Amp-dependent synthetase and ligase
VAPA_1c45760	COG3320	Male sterility
VAPA_1c45790	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c45820	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VAPA_1c45860	COG5507	3-demethylubiquinone-9 3-methyltransferase
VAPA_1c45900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPA_1c45910	COG0430	RNA-3'-phosphate cyclase activity
VAPA_1c45930	COG1690	Belongs to the RtcB family
VAPA_1c45950	COG4650	regulator
VAPA_1c45970	COG1073	alpha beta
VAPA_1c45980	COG2423	ornithine cyclodeaminase activity
VAPA_1c46020	COG1764	response to oxidative stress
VAPA_1c46030	COG0745	RESPONSE REGULATOR receiver
VAPA_1c46090	COG0183	Belongs to the thiolase family
VAPA_1c46100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VAPA_1c46120	COG1414	Transcriptional regulator
VAPA_1c46150	COG3063	Type IV pilus biogenesis stability protein PilW
VAPA_1c46200	COG4964	Belongs to the GSP D family
VAPA_1c46320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_1c46330	COG2274	protein secretion by the type I secretion system
VAPA_1c46350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAPA_1c46390	COG0583	DNA-binding transcription factor activity
VAPA_1c46400	COG3485	protocatechuate 3,4-dioxygenase
VAPA_1c46410	COG3485	protocatechuate 3,4-dioxygenase
VAPA_1c46430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_1c46560	COG0469	pyruvate kinase activity
VAPA_1c46570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_1c46590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VAPA_1c46600	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_1c46620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c46630	COG4191	Histidine kinase
VAPA_1c46740	COG0582	viral genome integration into host DNA
VAPA_1c46790	COG0714	Associated with various cellular activities
VAPA_1c46800	COG3831	ATPase activity
VAPA_1c46820	COG3552	Protein containing von Willebrand factor type A (VWA) domain
VAPA_1c47080	COG2274	protein secretion by the type I secretion system
VAPA_1c47120	COG0745	RESPONSE REGULATOR receiver
VAPA_1c47130	COG0745	RESPONSE REGULATOR receiver
VAPA_1c47140	COG2205	protein histidine kinase activity
VAPA_1c47160	COG4804	nuclease activity
VAPA_1c47280	COG0514	ATP-dependent DNA helicase (RecQ)
VAPA_1c47370	COG1431	PFAM Stem cell self-renewal protein Piwi
VAPA_1c47460	COG1484	DNA-dependent DNA replication
VAPA_1c47490	COG2207	Transcriptional regulator
VAPA_1c47550	COG0540	Belongs to the ATCase OTCase family
VAPA_1c47560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VAPA_1c47570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAPA_1c47580	COG1678	Uncharacterized ACR, COG1678
VAPA_1c47590	COG0415	Belongs to the DNA photolyase family
VAPA_1c47630	COG0840	transmembrane signaling receptor activity
VAPA_1c47670	COG1773	rubredoxin
VAPA_1c47690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAPA_1c47700	COG0154	amidase activity
VAPA_1c47730	COG0138	bifunctional purine biosynthesis protein purh
VAPA_1c47760	COG1238	metal cluster binding
VAPA_1c47790	COG0012	GTP binding
VAPA_1c47800	COG1879	ABC-type sugar transport system periplasmic component
VAPA_1c47810	COG1129	ABC transporter
VAPA_1c47820	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c47840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPA_1c47850	COG1869	D-ribose catabolic process
VAPA_1c47870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_1c47880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAPA_1c47900	COG1024	Enoyl-CoA hydratase
VAPA_1c47950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_1c47970	COG2863	cytochrome
VAPA_1c47980	COG2010	Cytochrome c
VAPA_1c48000	COG1230	cation diffusion facilitator family transporter
VAPA_1c48010	COG2255	four-way junction helicase activity
VAPA_1c48020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAPA_1c48030	COG2267	carboxylic ester hydrolase activity
VAPA_1c48040	COG0671	phosphoesterase, PA-phosphatase related
VAPA_1c48040	COG2453	phosphatase
VAPA_1c48070	COG4589	Belongs to the CDS family
VAPA_1c48110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAPA_1c48110	COG1042	CoA-binding domain protein
VAPA_1c48110	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_1c48160	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c48170	COG0632	four-way junction helicase activity
VAPA_1c48180	COG1702	phosphate starvation-inducible protein PhoH
VAPA_1c48190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VAPA_1c48200	COG1490	D-aminoacyl-tRNA deacylase activity
VAPA_1c48210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAPA_1c48250	COG0739	heme binding
VAPA_1c48260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAPA_1c48270	COG2814	Major facilitator Superfamily
VAPA_1c48280	COG0316	Belongs to the HesB IscA family
VAPA_1c48290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VAPA_1c48300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAPA_1c48310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAPA_1c48320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAPA_1c48350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VAPA_1c48400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VAPA_1c48430	COG4555	ABC transporter
VAPA_1c48470	COG2423	ornithine cyclodeaminase activity
VAPA_1c48490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAPA_1c48500	COG3842	ATPase activity
VAPA_1c48520	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_1c48530	COG1177	transmembrane transport
VAPA_1c48550	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_1c48560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAPA_1c48600	COG0477	Major facilitator Superfamily
VAPA_1c48670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c48700	COG1414	Transcriptional regulator
VAPA_1c48710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_1c48750	COG1024	Enoyl-CoA hydratase
VAPA_1c48760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPA_1c48770	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c48780	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c48810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPA_1c48860	COG0789	Transcriptional regulator
VAPA_1c48870	COG0288	reversible hydration of carbon dioxide
VAPA_1c48880	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VAPA_1c48890	COG0183	Belongs to the thiolase family
VAPA_1c48910	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c48920	COG3012	SEC-C Motif Domain Protein
VAPA_1c48930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAPA_1c48960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAPA_1c48970	COG0751	glycine-tRNA ligase activity
VAPA_1c48980	COG0752	glycyl-tRNA synthetase alpha subunit
VAPA_1c48990	COG1597	lipid kinase activity
VAPA_1c49000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_1c49010	COG0671	phosphoesterase, PA-phosphatase related
VAPA_1c49050	COG0288	reversible hydration of carbon dioxide
VAPA_1c49070	COG0583	DNA-binding transcription factor activity
VAPA_1c49080	COG2814	Major facilitator Superfamily
VAPA_1c49160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c49180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAPA_1c49190	COG4535	Mg2 and Co2 transporter CorC
VAPA_1c49210	COG1522	sequence-specific DNA binding
VAPA_1c49240	COG3186	Phenylalanine-4-hydroxylase
VAPA_1c49250	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c49380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_1c49400	COG4774	siderophore transport
VAPA_1c49470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_1c49570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VAPA_1c49580	COG0439	Biotin carboxylase
VAPA_1c49590	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c49680	COG1505	serine-type exopeptidase activity
VAPA_1c49740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VAPA_1c49820	COG2084	Dehydrogenase
VAPA_1c49840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAPA_1c49850	COG0792	nuclease activity
VAPA_1c49860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAPA_1c49920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPA_1c49930	COG0583	DNA-binding transcription factor activity
VAPA_1c49940	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c50000	COG1309	transcriptional regulator
VAPA_1c50010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_1c50020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_1c50030	COG1538	Outer membrane efflux protein
VAPA_1c50080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_1c50090	COG1335	isochorismatase
VAPA_1c50100	COG0251	oxidation-reduction process
VAPA_1c50110	COG2267	carboxylic ester hydrolase activity
VAPA_1c50120	COG0778	Nitroreductase
VAPA_1c50130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_1c50140	COG1309	transcriptional regulator
VAPA_1c50220	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
VAPA_1c50230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAPA_1c50240	COG3842	ATPase activity
VAPA_1c50250	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_1c50260	COG1177	transmembrane transport
VAPA_1c50320	COG3118	belongs to the thioredoxin family
VAPA_1c50330	COG1201	RNA secondary structure unwinding
VAPA_1c50340	COG1793	dna ligase
VAPA_1c50340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPA_1c50350	COG1793	dna ligase
VAPA_1c50350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPA_1c50410	COG1116	anion transmembrane transporter activity
VAPA_1c50460	COG0673	inositol 2-dehydrogenase activity
VAPA_1c50470	COG1879	ABC-type sugar transport system periplasmic component
VAPA_1c50480	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c50520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAPA_1c50530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAPA_1c50540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAPA_1c50550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAPA_1c50560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAPA_1c50570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAPA_1c50590	COG0356	it plays a direct role in the translocation of protons across the membrane
VAPA_1c50620	COG2921	Belongs to the UPF0250 family
VAPA_1c50630	COG0321	lipoyl(octanoyl) transferase activity
VAPA_1c50640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAPA_1c50650	COG0477	Major facilitator Superfamily
VAPA_1c50660	COG0583	DNA-binding transcription factor activity
VAPA_1c50670	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c50680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VAPA_1c50720	COG2130	NADP-dependent
VAPA_1c50730	COG2205	protein histidine kinase activity
VAPA_1c50740	COG0745	RESPONSE REGULATOR receiver
VAPA_1c50780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAPA_1c50790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAPA_1c50810	COG2814	Major facilitator Superfamily
VAPA_1c50830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPA_1c50850	COG0678	peroxiredoxin activity
VAPA_1c50860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAPA_1c50870	COG0255	Belongs to the universal ribosomal protein uL29 family
VAPA_1c50880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAPA_1c50890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VAPA_1c50900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VAPA_1c50910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAPA_1c50920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAPA_1c50930	COG0089	rRNA binding
VAPA_1c50940	COG0088	Forms part of the polypeptide exit tunnel
VAPA_1c50950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAPA_1c50980	COG0051	transcription antitermination factor activity, RNA binding
VAPA_1c50990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAPA_1c51000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAPA_1c51010	COG0049	tRNA binding
VAPA_1c51020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VAPA_1c51030	COG1686	Belongs to the peptidase S11 family
VAPA_1c51040	COG2945	thiolester hydrolase activity
VAPA_1c51090	COG0598	Magnesium transport protein CorA
VAPA_1c51110	COG0583	DNA-binding transcription factor activity
VAPA_1c51120	COG0412	Dienelactone hydrolase
VAPA_1c51140	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c51150	COG2095	MarC family integral membrane protein
VAPA_1c51190	COG0410	ABC transporter
VAPA_1c51200	COG0411	ABC transporter
VAPA_1c51220	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c51250	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VAPA_1c51260	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_1c51290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VAPA_1c51300	COG1652	LysM domain
VAPA_1c51320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAPA_1c51350	COG0574	Belongs to the PEP-utilizing enzyme family
VAPA_1c51350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAPA_1c51380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_1c51400	COG4208	sulfate ABC transporter
VAPA_1c51450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAPA_1c51470	COG0640	Transcriptional regulator
VAPA_1c51480	COG2124	cytochrome p450
VAPA_1c51500	COG0625	glutathione transferase activity
VAPA_1c51510	COG0583	DNA-binding transcription factor activity
VAPA_1c51540	COG1131	(ABC) transporter
VAPA_1c51560	COG1846	Transcriptional regulator
VAPA_1c51570	COG1764	response to oxidative stress
VAPA_1c51590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAPA_1c51600	COG0583	DNA-binding transcription factor activity
VAPA_1c51610	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c51620	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c51630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_1c51660	COG0326	Molecular chaperone. Has ATPase activity
VAPA_1c51670	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPA_1c51680	COG0583	DNA-binding transcription factor activity
VAPA_1c51700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VAPA_1c51720	COG0642	Histidine kinase
VAPA_1c51730	COG0745	RESPONSE REGULATOR receiver
VAPA_1c51750	COG1187	pseudouridine synthase activity
VAPA_1c51760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAPA_1c51800	COG0745	RESPONSE REGULATOR receiver
VAPA_1c51810	COG2205	protein histidine kinase activity
VAPA_1c51820	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
VAPA_1c51830	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
VAPA_1c51840	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VAPA_1c51870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VAPA_1c51920	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c51940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_1c51950	COG1022	Amp-dependent synthetase and ligase
VAPA_1c51960	COG0411	ABC transporter
VAPA_1c51970	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_1c52010	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_1c52030	COG0693	protein deglycase activity
VAPA_1c52110	COG4993	Dehydrogenase
VAPA_1c52120	COG1940	carbohydrate kinase activity
VAPA_1c52130	COG1129	ABC transporter
VAPA_1c52140	COG4214	carbohydrate transport
VAPA_1c52150	COG4213	ABC transporter substrate-binding protein
VAPA_1c52170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_1c52180	COG0583	DNA-binding transcription factor activity
VAPA_1c52200	COG4774	siderophore transport
VAPA_1c52210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VAPA_1c52220	COG0022	dehydrogenase e1 component
VAPA_1c52240	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_1c52250	COG0583	DNA-binding transcription factor activity
VAPA_1c52260	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c52280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAPA_1c52310	COG1024	Enoyl-CoA hydratase
VAPA_1c52320	COG1960	acyl-CoA dehydrogenase activity
VAPA_1c52360	COG0203	ribosomal protein L17
VAPA_1c52370	COG0202	RNA polymerase activity
VAPA_1c52380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAPA_1c52390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAPA_1c52400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAPA_1c52410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAPA_1c52420	COG0201	protein transport
VAPA_1c52430	COG0200	Binds to the 23S rRNA
VAPA_1c52440	COG1841	ribosomal large subunit assembly
VAPA_1c52450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAPA_1c52460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VAPA_1c52470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAPA_1c52480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAPA_1c52490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAPA_1c52500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAPA_1c52510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAPA_1c52520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAPA_1c52550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAPA_1c52560	COG0783	Belongs to the Dps family
VAPA_1c52580	COG1280	lysine exporter protein (LysE YggA)
VAPA_1c52590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAPA_1c52600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VAPA_1c52610	COG3386	PFAM SMP-30 Gluconolaconase
VAPA_1c52620	COG0343	queuine tRNA-ribosyltransferase activity
VAPA_1c52730	COG0284	orotidine-5'-phosphate decarboxylase activity
VAPA_1c52760	COG1214	PFAM Peptidase M22, glycoprotease
VAPA_1c52790	COG0494	nUDIX hydrolase
VAPA_1c52800	COG2027	D-alanyl-D-alanine carboxypeptidase
VAPA_1c52820	COG0009	L-threonylcarbamoyladenylate synthase
VAPA_1c52830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAPA_1c52840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAPA_1c52870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAPA_1c52890	COG1522	sequence-specific DNA binding
VAPA_1c52900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
VAPA_1c52910	COG0469	pyruvate kinase activity
VAPA_1c52920	COG0126	phosphoglycerate kinase activity
VAPA_1c52960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_1c53020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAPA_1c53040	COG0242	peptide deformylase activity
VAPA_1c53060	COG0758	DNA mediated transformation
VAPA_1c53070	COG2922	Belongs to the Smg family
VAPA_1c53090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAPA_1c53100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAPA_1c53130	COG1522	sequence-specific DNA binding
VAPA_1c53150	COG0765	amino acid transport
VAPA_1c53160	COG2814	Major facilitator Superfamily
VAPA_1c53180	COG1845	cytochrome c oxidase, subunit III
VAPA_1c53200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPA_1c53210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAPA_1c53250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_1c53310	COG0251	oxidation-reduction process
VAPA_1c53330	COG3622	Belongs to the hyi family
VAPA_1c53340	COG0235	Class ii aldolase
VAPA_1c53350	COG3395	kinase activity
VAPA_1c53360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_1c53370	COG2084	Dehydrogenase
VAPA_1c53380	COG2271	Major facilitator Superfamily
VAPA_1c53390	COG2186	Transcriptional regulator
VAPA_1c53410	COG1522	sequence-specific DNA binding
VAPA_1c53460	COG4566	intracellular signal transduction
VAPA_1c53480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_1c53500	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAPA_1c53510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAPA_1c53520	COG3550	peptidyl-serine autophosphorylation
VAPA_1c53530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAPA_1c53540	COG1595	DNA-templated transcription, initiation
VAPA_1c53570	COG0625	glutathione transferase activity
VAPA_1c53600	COG4772	TonB-dependent receptor
VAPA_1c53610	COG4681	YaeQ
VAPA_1c53640	COG0861	Integral membrane protein TerC family
VAPA_1c53660	COG1950	PFAM Membrane protein of
VAPA_1c53670	COG4783	chaperone-mediated protein folding
VAPA_1c53680	COG0315	cyclic pyranopterin monophosphate synthase activity
VAPA_1c53780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAPA_1c53790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAPA_1c53830	COG2226	methyltransferase
VAPA_1c53900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAPA_1c53930	COG4969	Belongs to the N-Me-Phe pilin family
VAPA_1c53960	COG1716	ATPase activity
VAPA_1c53980	COG0861	Integral membrane protein TerC family
VAPA_1c53990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VAPA_1c54000	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_1c54010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAPA_1c54020	COG2137	regulation of response to DNA damage stimulus
VAPA_1c54030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAPA_1c54060	COG0642	Histidine kinase
VAPA_1c54080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VAPA_1c54080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VAPA_1c54110	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c54120	COG0583	DNA-binding transcription factor activity
VAPA_1c54130	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_1c54150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VAPA_1c54180	COG2814	Major facilitator Superfamily
VAPA_1c54200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAPA_1c54210	COG0513	Belongs to the DEAD box helicase family
VAPA_1c54250	COG1802	Transcriptional regulator
VAPA_1c54280	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAPA_1c54280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_1c54310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_1c54330	COG1473	amidohydrolase
VAPA_1c54370	COG1802	Transcriptional regulator
VAPA_1c54400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPA_1c54410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_1c54420	COG4172	Belongs to the ABC transporter superfamily
VAPA_1c54430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_1c54450	COG0747	negative chemotaxis
VAPA_1c54470	COG1741	Belongs to the pirin family
VAPA_1c54500	COG2186	Transcriptional regulator
VAPA_1c54520	COG0765	amino acid transport
VAPA_1c54560	COG1047	Peptidyl-prolyl cis-trans
VAPA_1c54580	COG0154	amidase activity
VAPA_1c54640	COG1914	H( )-stimulated, divalent metal cation uptake system
VAPA_1c54650	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VAPA_1c54680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAPA_1c54690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAPA_1c54700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VAPA_1c54720	COG0006	proline dipeptidase activity
VAPA_1c54730	COG0583	DNA-binding transcription factor activity
VAPA_1c54760	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VAPA_1c54800	COG0281	malic enzyme
VAPA_1c54800	COG0280	phosphate acetyltransferase
VAPA_1c54840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAPA_1c54850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPA_1c54860	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VAPA_1c54880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAPA_1c54910	COG2814	Major facilitator Superfamily
VAPA_1c54920	COG2267	carboxylic ester hydrolase activity
VAPA_1c54960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_1c54970	COG1739	Uncharacterized protein family UPF0029
VAPA_1c54980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAPA_1c54990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAPA_1c55000	COG2119	membrane
VAPA_1c55010	COG0724	RNA recognition motif
VAPA_1c55020	COG0300	oxidoreductase activity
VAPA_1c55040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VAPA_1c55080	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAPA_1c55080	COG2066	Belongs to the glutaminase family
VAPA_1c55090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAPA_1c55100	COG0706	membrane insertase activity
VAPA_1c55110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VAPA_1c55120	COG0594	ribonuclease P activity
VAPA_1c55130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VAPA_2c00020	COG1475	DNA binding
VAPA_2c00030	COG4977	sequence-specific DNA binding
VAPA_2c00050	COG3916	Acyl-homoserine-lactone synthase
VAPA_2c00060	COG0697	spore germination
VAPA_2c00070	COG0512	Glutamine amidotransferase of anthranilate synthase
VAPA_2c00070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAPA_2c00080	COG1522	sequence-specific DNA binding
VAPA_2c00160	COG1024	Enoyl-CoA hydratase
VAPA_2c00180	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c00190	COG0583	DNA-binding transcription factor activity
VAPA_2c00260	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_2c00280	COG1137	ATPase activity
VAPA_2c00290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAPA_2c00300	COG0154	amidase activity
VAPA_2c00450	COG1024	Enoyl-CoA hydratase
VAPA_2c00460	COG0604	alcohol dehydrogenase
VAPA_2c00490	COG1289	transmembrane transporter activity
VAPA_2c00530	COG3254	rhamnose metabolic process
VAPA_2c00540	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_2c00600	COG1126	abc transporter atp-binding protein
VAPA_2c00660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_2c00670	COG0251	oxidation-reduction process
VAPA_2c00750	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_2c00760	COG0583	DNA-binding transcription factor activity
VAPA_2c00790	COG1733	regulation of RNA biosynthetic process
VAPA_2c00890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAPA_2c00920	COG2814	Major facilitator Superfamily
VAPA_2c00930	COG0543	2 iron, 2 sulfur cluster binding
VAPA_2c00940	COG0167	dihydroorotate dehydrogenase activity
VAPA_2c00950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_2c00980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAPA_2c01030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAPA_2c01050	COG1024	Enoyl-CoA hydratase
VAPA_2c01060	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_2c01080	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c01100	COG2030	dehydratase
VAPA_2c01140	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c01170	COG2207	Transcriptional regulator
VAPA_2c01220	COG1216	Glycosyl transferase, family 2
VAPA_2c01240	COG0625	glutathione transferase activity
VAPA_2c01280	COG0024	Methionine aminopeptidase
VAPA_2c01300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_2c01310	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c01340	COG0456	acetyltransferase
VAPA_2c01360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_2c01370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_2c01390	COG1850	ribulose-bisphosphate carboxylase activity
VAPA_2c01410	COG2186	Transcriptional regulator
VAPA_2c01420	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_2c01430	COG2084	Dehydrogenase
VAPA_2c01440	COG0583	DNA-binding transcription factor activity
VAPA_2c01450	COG2159	amidohydrolase
VAPA_2c01480	COG3384	dioxygenase
VAPA_2c01490	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c01530	COG0346	lactoylglutathione lyase activity
VAPA_2c01610	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c01620	COG2207	Transcriptional regulator
VAPA_2c01630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAPA_2c01680	COG0861	Integral membrane protein TerC family
VAPA_2c01720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_2c01730	COG1609	Transcriptional regulator
VAPA_2c01740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_2c01750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_2c01810	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_2c01880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAPA_2c01900	COG1819	glycosyl
VAPA_2c01910	COG1309	transcriptional regulator
VAPA_2c01960	COG2814	Major facilitator Superfamily
VAPA_2c01970	COG0745	RESPONSE REGULATOR receiver
VAPA_2c01970	COG3706	GGDEF domain
VAPA_2c01980	COG3284	Transcriptional regulator
VAPA_2c01990	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_2c02090	COG3209	COG3209 Rhs family protein
VAPA_2c02120	COG3209	COG3209 Rhs family protein
VAPA_2c02150	COG3209	COG3209 Rhs family protein
VAPA_2c02160	COG3501	Rhs element vgr protein
VAPA_2c02170	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_2c02180	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c02200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_2c02210	COG0583	DNA-binding transcription factor activity
VAPA_2c02220	COG0583	DNA-binding transcription factor activity
VAPA_2c02250	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c02280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_2c02290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_2c02380	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c02430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_2c02440	COG0583	DNA-binding transcription factor activity
VAPA_2c02500	COG0583	DNA-binding transcription factor activity
VAPA_2c02530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPA_2c02540	COG0284	orotidine-5'-phosphate decarboxylase activity
VAPA_2c02550	COG0789	Transcriptional regulator
VAPA_2c02560	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_2c02570	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_2c02590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_2c02600	COG0601	transmembrane transport
VAPA_2c02610	COG4166	transmembrane transport
VAPA_2c02620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_2c02650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_2c02660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPA_2c02670	COG1522	sequence-specific DNA binding
VAPA_2c02700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_2c02700	COG2022	thiamine diphosphate biosynthetic process
VAPA_2c02750	COG0154	amidase activity
VAPA_2c02820	COG1053	succinate dehydrogenase
VAPA_2c02890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_2c02900	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_2c02900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAPA_2c02910	COG2186	Transcriptional regulator
VAPA_2c02930	COG0445	tRNA wobble uridine modification
VAPA_2c02950	COG0583	DNA-binding transcription factor activity
VAPA_2c02960	COG0251	oxidation-reduction process
VAPA_2c02990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAPA_2c03010	COG0114	fumarate hydratase activity
VAPA_2c03030	COG1522	sequence-specific DNA binding
VAPA_2c03050	COG3386	PFAM SMP-30 Gluconolaconase
VAPA_2c03090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_2c03100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAPA_2c03130	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c03170	COG3501	Rhs element vgr protein
VAPA_2c03280	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPA_2c03290	COG0784	Response regulator, receiver
VAPA_2c03290	COG4191	Histidine kinase
VAPA_2c03330	COG0589	response to stress
VAPA_2c03340	COG0589	response to stress
VAPA_2c03370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPA_2c03440	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c03460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAPA_2c03470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_2c03510	COG4876	unkown
VAPA_2c03520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAPA_2c03530	COG0459	protein refolding
VAPA_2c03570	COG1022	Amp-dependent synthetase and ligase
VAPA_2c03630	COG0410	ABC transporter
VAPA_2c03640	COG0411	ABC transporter
VAPA_2c03660	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_2c03700	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_2c03740	COG1802	Transcriptional regulator
VAPA_2c03750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_2c03760	COG1116	anion transmembrane transporter activity
VAPA_2c03770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_2c03790	COG0642	Histidine kinase
VAPA_2c03800	COG0745	RESPONSE REGULATOR receiver
VAPA_2c03820	COG0640	Transcriptional regulator
VAPA_2c03840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VAPA_2c03880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_2c03890	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAPA_2c03900	COG1136	(ABC) transporter
VAPA_2c03960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_2c03970	COG0842	Transport permease protein
VAPA_2c03970	COG1129	ABC transporter
VAPA_2c03980	COG0842	Transport permease protein
VAPA_2c04030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VAPA_2c04050	COG1858	cytochrome C peroxidase
VAPA_2c04070	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
VAPA_2c04080	COG0745	RESPONSE REGULATOR receiver
VAPA_2c04090	COG0642	Histidine kinase
VAPA_2c04110	COG1796	DNA polymerase
VAPA_2c04110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VAPA_2c04140	COG0596	Alpha beta hydrolase
VAPA_2c04140	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAPA_2c04150	COG0022	dehydrogenase e1 component
VAPA_2c04160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VAPA_2c04320	COG1063	alcohol dehydrogenase
VAPA_2c04360	COG0494	nUDIX hydrolase
VAPA_2c04400	COG2151	metal-sulfur cluster biosynthetic enzyme
VAPA_2c04410	COG1959	2 iron, 2 sulfur cluster binding
VAPA_2c04420	COG3256	nitric oxide reductase
VAPA_2c04460	COG0778	Nitroreductase
VAPA_2c04470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAPA_2c04480	COG2070	2-Nitropropane dioxygenase
VAPA_2c04490	COG0288	reversible hydration of carbon dioxide
VAPA_2c04510	COG2181	nitrate reductase activity
VAPA_2c04520	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
VAPA_2c04530	COG1140	nitrate reductase beta subunit
VAPA_2c04540	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
VAPA_2c04570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VAPA_2c04630	COG1136	(ABC) transporter
VAPA_2c04630	COG0577	efflux transmembrane transporter activity
VAPA_2c04660	COG0071	Belongs to the small heat shock protein (HSP20) family
VAPA_2c04730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAPA_2c04750	COG0589	response to stress
VAPA_2c04760	COG3243	poly(R)-hydroxyalkanoic acid synthase
VAPA_2c04770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VAPA_2c04810	COG2823	Periplasmic or secreted lipoprotein
VAPA_2c04820	COG0183	Belongs to the thiolase family
VAPA_2c04850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAPA_2c04860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_2c04890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAPA_2c04890	COG0574	Belongs to the PEP-utilizing enzyme family
VAPA_2c04910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAPA_2c04950	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAPA_2c04960	COG1538	Outer membrane efflux protein
VAPA_2c05140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAPA_2c05200	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_2c05270	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VAPA_2c05320	COG3260	NADH ubiquinone oxidoreductase 20
VAPA_2c05330	COG0649	NAD binding
VAPA_2c05340	COG0651	ATP synthesis coupled electron transport
VAPA_2c05360	COG0650	Formate hydrogenlyase subunit 4
VAPA_2c05370	COG0651	ATP synthesis coupled electron transport
VAPA_2c05400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_2c05410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_2c05410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_2c05410	COG0649	NAD binding
VAPA_2c05420	COG0651	ATP synthesis coupled electron transport
VAPA_2c05450	COG0651	ATP synthesis coupled electron transport
VAPA_2c05490	COG0540	Belongs to the ATCase OTCase family
VAPA_2c05600	COG0583	DNA-binding transcription factor activity
VAPA_2c05610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_2c05630	COG1960	acyl-CoA dehydrogenase activity
VAPA_2c05640	COG1960	acyl-CoA dehydrogenase activity
VAPA_2c05650	COG1024	Enoyl-CoA hydratase
VAPA_2c05660	COG1042	CoA-binding domain protein
VAPA_2c05660	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_2c05660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAPA_2c05690	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
VAPA_2c05700	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c05710	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c05720	COG1733	regulation of RNA biosynthetic process
VAPA_2c05750	COG2207	Transcriptional regulator
VAPA_2c05760	COG2080	2 iron, 2 sulfur cluster binding
VAPA_2c05770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
VAPA_2c05780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_2c05790	COG2828	Protein conserved in bacteria
VAPA_2c05820	COG0583	DNA-binding transcription factor activity
VAPA_2c05830	COG1301	dicarboxylic acid transport
VAPA_2c05870	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
VAPA_2c05900	COG2226	methyltransferase
VAPA_2c05930	COG5002	protein histidine kinase activity
VAPA_2c05940	COG2204	response regulator
VAPA_2c06000	COG0674	pyruvate-flavodoxin oxidoreductase activity
VAPA_2c06000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VAPA_2c06070	COG0542	response to heat
VAPA_2c06080	COG5002	protein histidine kinase activity
VAPA_2c06130	COG4608	Belongs to the ABC transporter superfamily
VAPA_2c06150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_2c06160	COG0601	transmembrane transport
VAPA_2c06180	COG4166	transmembrane transport
VAPA_2c06230	COG4789	Type iii secretion
VAPA_2c06240	COG4794	Type iii secretion
VAPA_2c06350	COG4792	protein secretion
VAPA_2c06520	COG1477	protein flavinylation
VAPA_2c06560	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c06570	COG0183	Belongs to the thiolase family
VAPA_2c06580	COG1301	dicarboxylic acid transport
VAPA_2c06590	COG0596	Alpha beta hydrolase
VAPA_2c06610	COG3254	rhamnose metabolic process
VAPA_2c06620	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c06630	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_2c06660	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_2c06740	COG2186	Transcriptional regulator
VAPA_2c06770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_2c06800	COG1414	Transcriptional regulator
VAPA_2c06810	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_2c06830	COG1024	Enoyl-CoA hydratase
VAPA_2c06860	COG0583	DNA-binding transcription factor activity
VAPA_2c06870	COG1349	DNA-binding transcription factor activity
VAPA_2c06880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAPA_2c06890	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_2c06900	COG4154	Belongs to the RbsD FucU family
VAPA_2c06910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPA_2c06920	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_2c06940	COG1129	ABC transporter
VAPA_2c06980	COG1902	pentaerythritol trinitrate reductase activity
VAPA_2c07130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_2c07150	COG0583	DNA-binding transcription factor activity
VAPA_2c07170	COG0583	DNA-binding transcription factor activity
VAPA_2c07190	COG0745	RESPONSE REGULATOR receiver
VAPA_2c07200	COG2205	protein histidine kinase activity
VAPA_2c07210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_2c07220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_2c07230	COG1538	Outer membrane efflux protein
VAPA_2c07280	COG0765	amino acid transport
VAPA_2c07290	COG0765	amino acid transport
VAPA_2c07300	COG4221	oxidoreductase activity
VAPA_2c07310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAPA_2c07330	COG1984	allophanate hydrolase subunit 2
VAPA_2c07340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VAPA_2c07360	COG0511	ligase activity, forming carbon-carbon bonds
VAPA_2c07390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAPA_2c07470	COG2831	hemolysin activation secretion protein
VAPA_2c07570	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAPA_2c07610	COG3604	Transcriptional regulator
VAPA_2c07690	COG2205	protein histidine kinase activity
VAPA_2c07690	COG2198	Histidine kinase
VAPA_2c07690	COG0784	Response regulator, receiver
VAPA_2c07700	COG2197	response regulator
VAPA_2c07710	COG3210	domain, Protein
VAPA_2c07730	COG2963	transposase activity
VAPA_2c07780	COG2223	nitrite transmembrane transporter activity
VAPA_2c07790	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c07840	COG3220	belongs to the UPF0276 family
VAPA_2c07860	COG2133	pyrroloquinoline quinone binding
VAPA_2c07890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_2c07900	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_2c07920	COG2832	Protein of unknown function (DUF454)
VAPA_2c07970	COG0861	Integral membrane protein TerC family
VAPA_2c08000	COG1802	Transcriptional regulator
VAPA_2c08090	COG0543	2 iron, 2 sulfur cluster binding
VAPA_2c08090	COG0633	Ferredoxin
VAPA_2c08110	COG1335	isochorismatase
VAPA_2c08120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_2c08130	COG1116	anion transmembrane transporter activity
VAPA_2c08150	COG3069	C4-dicarboxylate transmembrane transporter activity
VAPA_2c08250	COG1397	ADP-ribosylglycohydrolase
VAPA_2c08260	COG1056	cytidyltransferase-related domain
VAPA_2c08260	COG1051	belongs to the nudix hydrolase family
VAPA_2c08270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_2c08270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAPA_2c08280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAPA_2c08380	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c08420	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c08460	COG0596	Alpha beta hydrolase
VAPA_2c08520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_2c08530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAPA_2c08570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VAPA_2c08580	COG3901	Regulator of nitric oxide reductase transcription
VAPA_2c08580	COG0348	domain, Protein
VAPA_2c08640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAPA_2c08720	COG2197	response regulator
VAPA_2c08730	COG2197	response regulator
VAPA_2c08770	COG2205	protein histidine kinase activity
VAPA_2c08770	COG0784	Response regulator, receiver
VAPA_2c08800	COG0583	DNA-binding transcription factor activity
VAPA_2c08830	COG0412	Dienelactone hydrolase
VAPA_2c08860	COG0154	amidase activity
VAPA_2c08870	COG3483	tryptophan 2,3-dioxygenase activity
VAPA_2c08890	COG0346	lactoylglutathione lyase activity
VAPA_2c08900	COG0655	NAD(P)H dehydrogenase (quinone) activity
VAPA_2c08910	COG0583	DNA-binding transcription factor activity
VAPA_2c08950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VAPA_2c08960	COG2207	Transcriptional regulator
VAPA_2c08970	COG2807	transmembrane transport
VAPA_2c08980	COG0625	glutathione transferase activity
VAPA_2c09000	COG0655	NAD(P)H dehydrogenase (quinone) activity
VAPA_2c09040	COG0625	glutathione transferase activity
VAPA_2c09110	COG2353	YceI-like domain
VAPA_2c09130	COG0753	catalase activity
VAPA_2c09140	COG0583	DNA-binding transcription factor activity
VAPA_2c09150	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c09230	COG0583	DNA-binding transcription factor activity
VAPA_2c09270	COG3039	Transposase
VAPA_2c09320	COG0625	glutathione transferase activity
VAPA_2c09340	COG1902	pentaerythritol trinitrate reductase activity
VAPA_2c09390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_2c09410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_2c09420	COG1538	Outer membrane efflux protein
VAPA_2c09430	COG1902	pentaerythritol trinitrate reductase activity
VAPA_2c09490	COG3436	PFAM IS66 Orf2 family protein
VAPA_2c09500	COG4372	Transposase
VAPA_2c09540	COG2831	hemolysin activation secretion protein
VAPA_2c09550	COG3210	domain, Protein
VAPA_2c09600	COG2188	Transcriptional regulator
VAPA_2c09610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPA_2c09640	COG1414	Transcriptional regulator
VAPA_2c09760	COG3119	arylsulfatase activity
VAPA_2c09840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_2c09890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_2c09940	COG0583	DNA-binding transcription factor activity
VAPA_2c09960	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c10000	COG2818	Glycosylase
VAPA_2c10030	COG2814	Major facilitator Superfamily
VAPA_2c10130	COG0583	DNA-binding transcription factor activity
VAPA_2c10150	COG2205	protein histidine kinase activity
VAPA_2c10170	COG0745	RESPONSE REGULATOR receiver
VAPA_2c10190	COG5295	Hep Hag repeat protein
VAPA_2c10240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_2c10310	COG2197	response regulator
VAPA_2c10350	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_2c10390	COG3485	protocatechuate 3,4-dioxygenase
VAPA_2c10430	COG1137	ATPase activity
VAPA_2c10470	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_2c10520	COG2169	Transcriptional regulator
VAPA_2c10580	COG0783	Belongs to the Dps family
VAPA_2c10610	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VAPA_2c10630	COG1335	isochorismatase
VAPA_2c10640	COG1741	Belongs to the pirin family
VAPA_2c10650	COG0583	DNA-binding transcription factor activity
VAPA_2c10690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_2c10710	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_2c10720	COG0417	DNA replication proofreading
VAPA_2c10730	COG0583	DNA-binding transcription factor activity
VAPA_2c10740	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c10750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPA_2c10770	COG1024	Enoyl-CoA hydratase
VAPA_2c10770	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_2c10800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_2c10850	COG0583	DNA-binding transcription factor activity
VAPA_2c10900	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c10910	COG0384	phenazine biosynthesis protein PhzF
VAPA_2c10930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_2c10990	COG5002	protein histidine kinase activity
VAPA_2c10990	COG3850	Histidine kinase
VAPA_2c11080	COG0277	FAD linked oxidase domain protein
VAPA_2c11120	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_2c11150	COG0784	Response regulator, receiver
VAPA_2c11150	COG2198	Histidine kinase
VAPA_2c11150	COG2205	protein histidine kinase activity
VAPA_2c11220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_2c11310	COG1475	DNA binding
VAPA_2c11320	COG1192	Involved in chromosome partitioning
VAPA_2c11380	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_2c11400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAPA_2c11410	COG0410	ABC transporter
VAPA_2c11450	COG0300	oxidoreductase activity
VAPA_2c11470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_2c11490	COG4191	Histidine kinase
VAPA_2c11510	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
VAPA_2c11520	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
VAPA_2c11530	COG1609	Transcriptional regulator
VAPA_2c11540	COG3624	Phosphonate C-P lyase system protein PhnG
VAPA_2c11560	COG3626	phosphonate metabolism
VAPA_2c11570	COG3627	carbon phosphorus lyase activity
VAPA_2c11580	COG4107	phosphonate C-P lyase system protein PhnK
VAPA_2c11590	COG4778	phosphonate C-P lyase system protein PhnL
VAPA_2c11600	COG3454	Phosphonate metabolism
VAPA_2c11610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VAPA_2c11620	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VAPA_2c11630	COG3639	organic phosphonate transmembrane transporter activity
VAPA_2c11730	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPA_2c11740	COG3842	ATPase activity
VAPA_2c11800	COG4133	protoheme IX ABC transporter activity
VAPA_2c11830	COG0583	DNA-binding transcription factor activity
VAPA_2c11990	COG3119	arylsulfatase activity
VAPA_2c12000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPA_2c12040	COG0277	FAD linked oxidase domain protein
VAPA_2c12050	COG1448	Aminotransferase
VAPA_2c12060	COG3483	tryptophan 2,3-dioxygenase activity
VAPA_2c12070	COG0251	oxidation-reduction process
VAPA_2c12080	COG2149	membrane
VAPA_2c12170	COG1484	DNA-dependent DNA replication
VAPA_2c12210	COG0154	amidase activity
VAPA_2c12270	COG3550	peptidyl-serine autophosphorylation
VAPA_2c12300	COG0410	ABC transporter
VAPA_2c12320	COG4177	L-phenylalanine transmembrane transporter activity
VAPA_2c12330	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_2c12380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_2c12390	COG2267	carboxylic ester hydrolase activity
VAPA_2c12410	COG0604	alcohol dehydrogenase
VAPA_2c12420	COG1309	transcriptional regulator
VAPA_2c12430	COG0590	tRNA wobble adenosine to inosine editing
VAPA_2c12510	COG0583	DNA-binding transcription factor activity
VAPA_2c12530	COG3842	ATPase activity
VAPA_2c12540	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_2c12550	COG1177	transmembrane transport
VAPA_2c12590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_2c12600	COG0251	oxidation-reduction process
VAPA_2c12620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VAPA_2c12660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAPA_2c12670	COG2226	methyltransferase
VAPA_2c12680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VAPA_2c12700	COG3550	peptidyl-serine autophosphorylation
VAPA_2c12730	COG0671	phosphoesterase, PA-phosphatase related
VAPA_2c12810	COG1484	DNA-dependent DNA replication
VAPA_2c12940	COG1126	abc transporter atp-binding protein
VAPA_2c12970	COG4215	(ABC) transporter
VAPA_2c13050	COG1396	sequence-specific DNA binding
VAPA_2c13070	COG4804	nuclease activity
VAPA_2c13230	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
VAPA_2c13270	COG3704	protein secretion by the type IV secretion system
VAPA_2c13290	COG3451	type IV secretory pathway VirB4