locus-tag	class	description
Varpa_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Varpa_0002	COG0592	DNA-directed DNA polymerase activity
Varpa_0003	COG0187	DNA topoisomerase II activity
Varpa_0008	COG1408	metallophosphoesterase
Varpa_0011	COG0392	lysyltransferase activity
Varpa_0012	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_0013	COG3568	Endonuclease Exonuclease Phosphatase
Varpa_0019	COG0454	-acetyltransferase
Varpa_0019	COG0456	acetyltransferase
Varpa_0020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Varpa_0024	COG4452	Inner membrane protein CreD
Varpa_0028	COG2205	protein histidine kinase activity
Varpa_0029	COG0745	RESPONSE REGULATOR receiver
Varpa_0032	COG2608	mercury ion transmembrane transporter activity
Varpa_0033	COG2217	Heavy metal translocating P-type atpase
Varpa_0034	COG0456	acetyltransferase
Varpa_0037	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Varpa_0039	COG0745	RESPONSE REGULATOR receiver
Varpa_0040	COG0642	Histidine kinase
Varpa_0041	COG0346	lactoylglutathione lyase activity
Varpa_0044	COG1902	pentaerythritol trinitrate reductase activity
Varpa_0046	COG1024	Enoyl-CoA hydratase
Varpa_0050	COG0445	tRNA wobble uridine modification
Varpa_0051	COG0357	Ribosomal RNA small subunit methyltransferase G
Varpa_0053	COG1192	Involved in chromosome partitioning
Varpa_0055	COG1475	DNA binding
Varpa_0057	COG0277	FAD linked oxidase domain protein
Varpa_0059	COG2096	Adenosyltransferase
Varpa_0066	COG0583	DNA-binding transcription factor activity
Varpa_0073	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Varpa_0074	COG2894	cell division
Varpa_0075	COG0850	regulation of cytokinetic process
Varpa_0076	COG2233	PERMEase
Varpa_0077	COG2050	protein possibly involved in aromatic compounds catabolism
Varpa_0079	COG1132	(ABC) transporter
Varpa_0084	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_0085	COG1024	Enoyl-CoA hydratase
Varpa_0089	COG1250	3-hydroxyacyl-CoA dehydrogenase
Varpa_0091	COG3246	L-lysine catabolic process to acetate
Varpa_0093	COG1942	4-Oxalocrotonate Tautomerase
Varpa_0094	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_0097	COG0411	ABC transporter
Varpa_0101	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Varpa_0105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Varpa_0114	COG3634	alkyl hydroperoxide reductase activity
Varpa_0116	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Varpa_0117	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_0118	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_0119	COG1116	anion transmembrane transporter activity
Varpa_0119	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_0122	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Varpa_0124	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Varpa_0128	COG2207	Transcriptional regulator
Varpa_0129	COG0583	DNA-binding transcription factor activity
Varpa_0130	COG1960	acyl-CoA dehydrogenase activity
Varpa_0131	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_0135	COG1276	copper resistance
Varpa_0137	COG1573	uracil-dna glycosylase
Varpa_0140	COG0583	DNA-binding transcription factor activity
Varpa_0141	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Varpa_0145	COG2066	Belongs to the glutaminase family
Varpa_0151	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Varpa_0152	COG0583	DNA-binding transcription factor activity
Varpa_0153	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Varpa_0154	COG0700	Nucleoside recognition
Varpa_0155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_0158	COG0410	ABC transporter
Varpa_0162	COG0683	leucine binding
Varpa_0163	COG0633	Ferredoxin
Varpa_0172	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Varpa_0174	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Varpa_0175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Varpa_0177	COG1957	nucleoside hydrolase
Varpa_0180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_0181	COG1116	anion transmembrane transporter activity
Varpa_0183	COG2986	histidine ammonia-lyase
Varpa_0184	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Varpa_0190	COG1228	amidohydrolase
Varpa_0191	COG0402	S-adenosylhomocysteine deaminase activity
Varpa_0196	COG0583	DNA-binding transcription factor activity
Varpa_0199	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Varpa_0200	COG0646	methionine synthase
Varpa_0200	COG1410	methionine synthase
Varpa_0205	COG1309	transcriptional regulator
Varpa_0211	COG0683	leucine binding
Varpa_0213	COG0411	ABC transporter
Varpa_0215	COG1335	isochorismatase
Varpa_0217	COG2080	2 iron, 2 sulfur cluster binding
Varpa_0218	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Varpa_0218	COG2010	Cytochrome c
Varpa_0220	COG0606	chelatase, subunit chli
Varpa_0222	COG0347	Belongs to the P(II) protein family
Varpa_0223	COG0004	ammonium transporteR
Varpa_0225	COG0583	DNA-binding transcription factor activity
Varpa_0226	COG0277	FAD linked oxidase domain protein
Varpa_0227	COG0277	FAD linked oxidase domain protein
Varpa_0228	COG0247	lactate metabolic process
Varpa_0230	COG0386	Belongs to the glutathione peroxidase family
Varpa_0232	COG0477	Major facilitator Superfamily
Varpa_0233	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Varpa_0237	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Varpa_0242	COG3971	2-oxopent-4-enoate hydratase activity
Varpa_0247	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_0251	COG1846	Transcriptional regulator
Varpa_0257	COG1473	amidohydrolase
Varpa_0258	COG2974	May be involved in recombination
Varpa_0265	COG0745	RESPONSE REGULATOR receiver
Varpa_0266	COG0644	oxidoreductase
Varpa_0272	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_0273	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_0279	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Varpa_0280	COG1335	isochorismatase
Varpa_0286	COG0583	DNA-binding transcription factor activity
Varpa_0287	COG0708	Exodeoxyribonuclease III
Varpa_0288	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Varpa_0290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Varpa_0291	COG0154	amidase activity
Varpa_0292	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Varpa_0293	COG1077	Cell shape determining protein MreB Mrl
Varpa_0296	COG0768	penicillin binding
Varpa_0297	COG0179	Fumarylacetoacetate (FAA) hydrolase
Varpa_0299	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Varpa_0301	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_0304	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Varpa_0309	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Varpa_0310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Varpa_0311	COG0583	DNA-binding transcription factor activity
Varpa_0319	COG1177	transmembrane transport
Varpa_0320	COG1176	ABC-type spermidine putrescine transport system, permease component I
Varpa_0321	COG3842	ATPase activity
Varpa_0327	COG0028	Belongs to the TPP enzyme family
Varpa_0329	COG1473	amidohydrolase
Varpa_0330	COG0584	glycerophosphoryl diester phosphodiesterase
Varpa_0332	COG2733	membrane
Varpa_0335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Varpa_0338	COG1960	acyl-CoA dehydrogenase activity
Varpa_0339	COG1960	acyl-CoA dehydrogenase activity
Varpa_0341	COG0513	Belongs to the DEAD box helicase family
Varpa_0342	COG0023	Translation Initiation Factor
Varpa_0344	COG0724	RNA recognition motif
Varpa_0347	COG0004	ammonium transporteR
Varpa_0350	COG0243	molybdopterin cofactor binding
Varpa_0353	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_0354	COG1070	Carbohydrate kinase
Varpa_0355	COG1063	alcohol dehydrogenase
Varpa_0356	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_0358	COG1879	ABC-type sugar transport system periplasmic component
Varpa_0359	COG4977	sequence-specific DNA binding
Varpa_0360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_0367	COG0583	DNA-binding transcription factor activity
Varpa_0370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_0372	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_0373	COG0492	ferredoxin-NADP+ reductase activity
Varpa_0375	COG1946	Acyl-CoA thioesterase
Varpa_0378	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_0379	COG0659	secondary active sulfate transmembrane transporter activity
Varpa_0381	COG0410	ABC transporter
Varpa_0382	COG0411	ABC transporter
Varpa_0384	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_0389	COG0667	Aldo Keto reductase
Varpa_0390	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_0391	COG1129	ABC transporter
Varpa_0394	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Varpa_0398	COG0629	single-stranded DNA binding
Varpa_0401	COG0217	transcriptional regulatory protein
Varpa_0402	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Varpa_0403	COG1122	ATPase activity
Varpa_0405	COG1268	BioY protein
Varpa_0412	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Varpa_0413	COG0482	sulfurtransferase activity
Varpa_0416	COG0745	RESPONSE REGULATOR receiver
Varpa_0417	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Varpa_0418	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Varpa_0419	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Varpa_0420	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_0421	COG0601	transmembrane transport
Varpa_0422	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_0423	COG0444	Belongs to the ABC transporter superfamily
Varpa_0424	COG4608	Belongs to the ABC transporter superfamily
Varpa_0425	COG0747	negative chemotaxis
Varpa_0426	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Varpa_0428	COG0598	Magnesium transport protein CorA
Varpa_0430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Varpa_0432	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Varpa_0433	COG0735	belongs to the Fur family
Varpa_0434	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Varpa_0438	COG0058	SHG alpha-glucan phosphorylase activity
Varpa_0439	COG0297	glycogen (starch) synthase activity
Varpa_0440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Varpa_0441	COG1523	belongs to the glycosyl hydrolase 13 family
Varpa_0444	COG0366	Alpha amylase catalytic
Varpa_0445	COG2072	flavoprotein involved in K transport
Varpa_0446	COG0495	leucyl-tRNA aminoacylation
Varpa_0449	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Varpa_0451	COG3158	transport of potassium into the cell
Varpa_0454	COG0189	ligase activity
Varpa_0457	COG0121	glutamine amidotransferase
Varpa_0459	COG2814	Major facilitator Superfamily
Varpa_0462	COG0205	6-phosphofructokinase activity
Varpa_0463	COG1024	Enoyl-CoA hydratase
Varpa_0465	COG0583	DNA-binding transcription factor activity
Varpa_0466	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Varpa_0469	COG4804	nuclease activity
Varpa_0471	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Varpa_0474	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Varpa_0475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_0479	COG0018	arginyl-trna synthetase
Varpa_0481	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Varpa_0482	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Varpa_0483	COG1137	ATPase activity
Varpa_0484	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Varpa_0485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_0489	COG3038	cytochrome b561
Varpa_0509	COG0069	glutamate synthase activity
Varpa_0510	COG3318	Belongs to the UPF0149 family
Varpa_0510	COG3012	SEC-C Motif Domain Protein
Varpa_0519	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_0524	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Varpa_0527	COG2967	ApaG domain
Varpa_0528	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Varpa_0537	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_0538	COG3501	Rhs element vgr protein
Varpa_0541	COG3210	domain, Protein
Varpa_0544	COG1335	isochorismatase
Varpa_0546	COG5002	protein histidine kinase activity
Varpa_0548	COG0784	Response regulator, receiver
Varpa_0548	COG2198	Histidine kinase
Varpa_0548	COG2205	protein histidine kinase activity
Varpa_0549	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Varpa_0550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Varpa_0556	COG0515	serine threonine protein kinase
Varpa_0568	COG3501	Rhs element vgr protein
Varpa_0573	COG3501	Rhs element vgr protein
Varpa_0592	COG2072	flavoprotein involved in K transport
Varpa_0594	COG2144	transferase activity, transferring acyl groups
Varpa_0599	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_0601	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_0604	COG1522	sequence-specific DNA binding
Varpa_0605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Varpa_0606	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Varpa_0609	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_0610	COG4166	transmembrane transport
Varpa_0611	COG0601	transmembrane transport
Varpa_0612	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_0614	COG0473	3-isopropylmalate dehydrogenase activity
Varpa_0615	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_0618	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_0619	COG1247	-acetyltransferase
Varpa_0620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_0624	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Varpa_0625	COG1522	sequence-specific DNA binding
Varpa_0626	COG0546	phosphoglycolate phosphatase activity
Varpa_0632	COG1280	lysine exporter protein (LysE YggA)
Varpa_0633	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Varpa_0634	COG0134	indole-3-glycerol-phosphate synthase activity
Varpa_0635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Varpa_0636	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Varpa_0639	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Varpa_0640	COG0081	regulation of translation
Varpa_0641	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Varpa_0642	COG0222	ribosome binding
Varpa_0643	COG0085	RNA polymerase activity
Varpa_0644	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Varpa_0648	COG5000	phosphorelay sensor kinase activity
Varpa_0649	COG2204	response regulator
Varpa_0653	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Varpa_0672	COG0582	viral genome integration into host DNA
Varpa_0686	COG0363	glucosamine-6-phosphate deaminase activity
Varpa_0690	COG1573	uracil-dna glycosylase
Varpa_0698	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Varpa_0699	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Varpa_0700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Varpa_0701	COG4770	biotin carboxylase activity
Varpa_0705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_0709	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Varpa_0710	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Varpa_0712	COG0535	radical SAM domain protein
Varpa_0715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Varpa_0716	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Varpa_0717	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Varpa_0718	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_0720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_0722	COG1609	Transcriptional regulator
Varpa_0722	COG2207	Transcriptional regulator
Varpa_0726	COG0745	RESPONSE REGULATOR receiver
Varpa_0727	COG1764	response to oxidative stress
Varpa_0730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Varpa_0732	COG1301	dicarboxylic acid transport
Varpa_0733	COG0183	Belongs to the thiolase family
Varpa_0734	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_0737	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Varpa_0740	COG0210	DNA helicase
Varpa_0741	COG0679	Auxin Efflux Carrier
Varpa_0745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Varpa_0746	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Varpa_0748	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Varpa_0749	COG4232	protein-disulfide reductase activity
Varpa_0755	COG0583	DNA-binding transcription factor activity
Varpa_0756	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_0758	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Varpa_0761	COG0384	phenazine biosynthesis protein PhzF
Varpa_0762	COG0625	glutathione transferase activity
Varpa_0764	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_0765	COG0697	spore germination
Varpa_0767	COG0436	Aminotransferase
Varpa_0770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_0774	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Varpa_0777	COG0297	glycogen (starch) synthase activity
Varpa_0779	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Varpa_0780	COG1215	transferase activity, transferring glycosyl groups
Varpa_0786	COG1216	Glycosyl transferase, family 2
Varpa_0795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Varpa_0795	COG2755	lipolytic protein G-D-S-L family
Varpa_0798	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Varpa_0800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Varpa_0802	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_0803	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_0804	COG1129	ABC transporter
Varpa_0805	COG1879	ABC-type sugar transport system periplasmic component
Varpa_0806	COG2721	sulfolactate sulfo-lyase activity
Varpa_0807	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Varpa_0809	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_0810	COG2186	Transcriptional regulator
Varpa_0811	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_0812	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_0815	COG2188	Transcriptional regulator
Varpa_0816	COG0683	leucine binding
Varpa_0819	COG0411	ABC transporter
Varpa_0820	COG0410	ABC transporter
Varpa_0822	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Varpa_0823	COG0066	3-isopropylmalate dehydratase activity
Varpa_0827	COG3573	Dehydrogenase
Varpa_0829	COG0583	DNA-binding transcription factor activity
Varpa_0830	COG4221	oxidoreductase activity
Varpa_0835	COG1960	acyl-CoA dehydrogenase activity
Varpa_0837	COG1250	3-hydroxyacyl-CoA dehydrogenase
Varpa_0837	COG1024	Enoyl-CoA hydratase
Varpa_0838	COG2852	Protein conserved in bacteria
Varpa_0839	COG0183	Belongs to the thiolase family
Varpa_0844	COG1024	Enoyl-CoA hydratase
Varpa_0845	COG0683	leucine binding
Varpa_0846	COG1607	acyl-coa hydrolase
Varpa_0847	COG5265	(ABC) transporter
Varpa_0848	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Varpa_0849	COG0154	amidase activity
Varpa_0850	COG0583	DNA-binding transcription factor activity
Varpa_0851	COG1027	Aspartate ammonia-lyase
Varpa_0852	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Varpa_0853	COG0765	amino acid transport
Varpa_0854	COG0765	amino acid transport
Varpa_0855	COG1126	abc transporter atp-binding protein
Varpa_0857	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_0859	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Varpa_0860	COG0583	DNA-binding transcription factor activity
Varpa_0861	COG0656	L-ascorbic acid biosynthetic process
Varpa_0867	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Varpa_0873	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_0875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_0877	COG1960	acyl-CoA dehydrogenase activity
Varpa_0878	COG1960	acyl-CoA dehydrogenase activity
Varpa_0879	COG0183	Belongs to the thiolase family
Varpa_0881	COG0583	DNA-binding transcription factor activity
Varpa_0883	COG1881	PFAM PEBP family protein
Varpa_0886	COG1573	uracil-dna glycosylase
Varpa_0889	COG0154	amidase activity
Varpa_0890	COG0444	Belongs to the ABC transporter superfamily
Varpa_0891	COG4608	Belongs to the ABC transporter superfamily
Varpa_0892	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_0894	COG0747	negative chemotaxis
Varpa_0896	COG0418	dihydroorotase activity
Varpa_0900	COG0501	Belongs to the peptidase M48B family
Varpa_0902	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Varpa_0904	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Varpa_0906	COG1275	C4-dicarboxylate transporter malic acid transport protein
Varpa_0909	COG1289	transmembrane transporter activity
Varpa_0911	COG1566	PFAM secretion protein HlyD family protein
Varpa_0913	COG2814	Major facilitator Superfamily
Varpa_0915	COG1187	pseudouridine synthase activity
Varpa_0917	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_0928	COG0583	DNA-binding transcription factor activity
Varpa_0931	COG1335	isochorismatase
Varpa_0935	COG2207	Transcriptional regulator
Varpa_0939	COG2207	Transcriptional regulator
Varpa_0942	COG2814	Major facilitator Superfamily
Varpa_0949	COG1595	DNA-templated transcription, initiation
Varpa_0953	COG0583	DNA-binding transcription factor activity
Varpa_0954	COG1335	isochorismatase
Varpa_0956	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Varpa_0957	COG2259	Doxx family
Varpa_0959	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Varpa_0962	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Varpa_0963	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Varpa_0964	COG0523	cobalamin synthesis protein
Varpa_0966	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Varpa_0968	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Varpa_0969	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Varpa_0970	COG2001	Belongs to the MraZ family
Varpa_0971	COG0275	rRNA processing
Varpa_0974	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Varpa_0975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Varpa_0976	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Varpa_0977	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Varpa_0978	COG0772	Belongs to the SEDS family
Varpa_0979	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Varpa_0980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Varpa_0981	COG1181	Belongs to the D-alanine--D-alanine ligase family
Varpa_0982	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Varpa_0985	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Varpa_0987	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Varpa_0988	COG0575	Belongs to the CDS family
Varpa_0992	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Varpa_0995	COG3150	esterase
Varpa_0996	COG2197	response regulator
Varpa_0997	COG4585	Histidine kinase
Varpa_0998	COG0772	Belongs to the SEDS family
Varpa_0999	COG0312	modulator of DNA gyrase
Varpa_1001	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Varpa_1003	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Varpa_1005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Varpa_1006	COG0511	ligase activity, forming carbon-carbon bonds
Varpa_1007	COG0439	Biotin carboxylase
Varpa_1008	COG2264	protein methyltransferase activity
Varpa_1013	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Varpa_1013	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Varpa_1018	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Varpa_1019	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Varpa_1021	COG2204	response regulator
Varpa_1023	COG2205	protein histidine kinase activity
Varpa_1024	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Varpa_1027	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Varpa_1034	COG0037	tRNA processing
Varpa_1037	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1039	COG2175	clavaminate synthase activity
Varpa_1041	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Varpa_1042	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_1049	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_1051	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Varpa_1052	COG3387	PFAM Glycoside hydrolase 15-related
Varpa_1053	COG1877	trehalose-phosphatase activity
Varpa_1055	COG0617	tRNA 3'-terminal CCA addition
Varpa_1057	COG0625	glutathione transferase activity
Varpa_1058	COG1285	pathogenesis
Varpa_1060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Varpa_1061	COG0583	DNA-binding transcription factor activity
Varpa_1064	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Varpa_1066	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Varpa_1067	COG1522	sequence-specific DNA binding
Varpa_1068	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Varpa_1069	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Varpa_1074	COG3842	ATPase activity
Varpa_1077	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1079	COG1129	ABC transporter
Varpa_1080	COG1879	ABC-type sugar transport system periplasmic component
Varpa_1081	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_1082	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Varpa_1083	COG4154	Belongs to the RbsD FucU family
Varpa_1084	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_1085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Varpa_1086	COG1349	DNA-binding transcription factor activity
Varpa_1087	COG1522	sequence-specific DNA binding
Varpa_1090	COG1596	polysaccharide export
Varpa_1101	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Varpa_1101	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Varpa_1101	COG0506	proline dehydrogenase activity
Varpa_1105	COG1902	pentaerythritol trinitrate reductase activity
Varpa_1106	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Varpa_1109	COG3386	PFAM SMP-30 Gluconolaconase
Varpa_1110	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1112	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_1113	COG1879	ABC-type sugar transport system periplasmic component
Varpa_1114	COG4213	ABC transporter substrate-binding protein
Varpa_1116	COG4214	carbohydrate transport
Varpa_1117	COG1129	ABC transporter
Varpa_1118	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_1119	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_1122	COG0583	DNA-binding transcription factor activity
Varpa_1123	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1129	COG1132	(ABC) transporter
Varpa_1133	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Varpa_1134	COG4178	(ABC) transporter
Varpa_1136	COG1840	ABC-type Fe3 transport system, periplasmic component
Varpa_1138	COG3842	ATPase activity
Varpa_1140	COG2271	Major facilitator Superfamily
Varpa_1141	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_1143	COG2863	cytochrome
Varpa_1166	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Varpa_1169	COG1765	OsmC-like protein
Varpa_1170	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Varpa_1175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_1176	COG0444	Belongs to the ABC transporter superfamily
Varpa_1177	COG4608	Belongs to the ABC transporter superfamily
Varpa_1179	COG3384	dioxygenase
Varpa_1180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Varpa_1181	COG1840	ABC-type Fe3 transport system, periplasmic component
Varpa_1183	COG3842	ATPase activity
Varpa_1186	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Varpa_1187	COG0166	Belongs to the GPI family
Varpa_1192	COG1175	transmembrane transport
Varpa_1193	COG0395	ABC-type sugar transport system, permease component
Varpa_1194	COG3842	ATPase activity
Varpa_1195	COG0246	Mannitol dehydrogenase
Varpa_1197	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Varpa_1199	COG2207	Transcriptional regulator
Varpa_1199	COG4753	response regulator
Varpa_1200	COG1070	Carbohydrate kinase
Varpa_1201	COG0459	protein refolding
Varpa_1202	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Varpa_1204	COG0583	DNA-binding transcription factor activity
Varpa_1207	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_1208	COG4774	siderophore transport
Varpa_1211	COG4772	TonB-dependent receptor
Varpa_1212	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Varpa_1214	COG1560	Kdo2-lipid A biosynthetic process
Varpa_1216	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Varpa_1218	COG1333	cytochrome c biogenesis protein
Varpa_1219	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Varpa_1220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Varpa_1221	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Varpa_1222	COG0019	diaminopimelate decarboxylase activity
Varpa_1224	COG1965	Belongs to the frataxin family
Varpa_1231	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Varpa_1232	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Varpa_1233	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Varpa_1238	COG0070	glutamate synthase
Varpa_1238	COG0069	glutamate synthase activity
Varpa_1238	COG0067	glutamate synthase
Varpa_1240	COG1127	ABC transporter
Varpa_1241	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Varpa_1242	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Varpa_1243	COG2853	Lipoprotein
Varpa_1246	COG1131	(ABC) transporter
Varpa_1247	COG0842	Transport permease protein
Varpa_1248	COG5007	Belongs to the BolA IbaG family
Varpa_1249	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Varpa_1250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Varpa_1255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Varpa_1256	COG0131	Imidazoleglycerol-phosphate dehydratase
Varpa_1258	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Varpa_1259	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Varpa_1261	COG1301	dicarboxylic acid transport
Varpa_1263	COG0107	imidazoleglycerol-phosphate synthase activity
Varpa_1264	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Varpa_1265	COG0140	phosphoribosyl-ATP diphosphatase activity
Varpa_1267	COG0537	adenosine 5'-monophosphoramidase activity
Varpa_1268	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Varpa_1269	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Varpa_1270	COG0805	protein transport
Varpa_1273	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Varpa_1274	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Varpa_1275	COG1970	mechanosensitive ion channel activity
Varpa_1276	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
Varpa_1278	COG2197	response regulator
Varpa_1279	COG0723	plastoquinol--plastocyanin reductase activity
Varpa_1280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Varpa_1281	COG2857	Cytochrome c1
Varpa_1282	COG0625	glutathione transferase activity
Varpa_1283	COG2969	positive regulation of protein catabolic process
Varpa_1284	COG4221	oxidoreductase activity
Varpa_1287	COG5002	protein histidine kinase activity
Varpa_1287	COG0784	Response regulator, receiver
Varpa_1287	COG2205	protein histidine kinase activity
Varpa_1288	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Varpa_1290	COG4591	ABC-type transport system involved in lipoprotein release permease component
Varpa_1291	COG1136	(ABC) transporter
Varpa_1292	COG1595	DNA-templated transcription, initiation
Varpa_1293	COG0740	serine-type endopeptidase activity
Varpa_1297	COG0601	transmembrane transport
Varpa_1303	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Varpa_1308	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Varpa_1310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Varpa_1315	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Varpa_1316	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Varpa_1318	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1319	COG2030	dehydratase
Varpa_1319	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_1321	COG0411	ABC transporter
Varpa_1324	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Varpa_1325	COG2151	metal-sulfur cluster biosynthetic enzyme
Varpa_1326	COG3396	Phenylacetate-CoA oxygenase
Varpa_1327	COG3460	Phenylacetate-CoA oxygenase
Varpa_1328	COG3396	Phenylacetate-CoA oxygenase
Varpa_1330	COG2050	protein possibly involved in aromatic compounds catabolism
Varpa_1331	COG1024	Enoyl-CoA hydratase
Varpa_1333	COG1309	transcriptional regulator
Varpa_1334	COG0300	oxidoreductase activity
Varpa_1336	COG2304	oxidoreductase activity
Varpa_1338	COG0714	Associated with various cellular activities
Varpa_1339	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Varpa_1340	COG0084	hydrolase, TatD family'
Varpa_1343	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Varpa_1344	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Varpa_1347	COG0583	DNA-binding transcription factor activity
Varpa_1351	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Varpa_1361	COG1283	sodium-dependent phosphate transmembrane transporter activity
Varpa_1362	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Varpa_1367	COG1609	Transcriptional regulator
Varpa_1368	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Varpa_1370	COG0196	riboflavin kinase activity
Varpa_1373	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Varpa_1375	COG1960	acyl-CoA dehydrogenase activity
Varpa_1376	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Varpa_1380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Varpa_1380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Varpa_1382	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Varpa_1383	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Varpa_1384	COG0492	ferredoxin-NADP+ reductase activity
Varpa_1386	COG1674	ftsk spoiiie
Varpa_1387	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Varpa_1388	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Varpa_1389	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_1391	COG0411	ABC transporter
Varpa_1398	COG2816	NAD+ diphosphatase activity
Varpa_1399	COG0425	Belongs to the sulfur carrier protein TusA family
Varpa_1401	COG0525	valine-tRNA ligase activity
Varpa_1402	COG3022	response to hydroperoxide
Varpa_1404	COG2267	carboxylic ester hydrolase activity
Varpa_1405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Varpa_1405	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Varpa_1406	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1409	COG1960	acyl-CoA dehydrogenase activity
Varpa_1411	COG1960	acyl-CoA dehydrogenase activity
Varpa_1413	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_1418	COG0540	Belongs to the ATCase OTCase family
Varpa_1420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Varpa_1421	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
Varpa_1423	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_1424	COG0583	DNA-binding transcription factor activity
Varpa_1425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Varpa_1432	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1435	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_1437	COG4948	Mandelate Racemase Muconate Lactonizing
Varpa_1438	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1441	COG0477	Major facilitator Superfamily
Varpa_1442	COG1304	FMN binding
Varpa_1443	COG0583	DNA-binding transcription factor activity
Varpa_1444	COG1620	l-lactate permease
Varpa_1447	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Varpa_1448	COG4221	oxidoreductase activity
Varpa_1453	COG2832	Protein of unknown function (DUF454)
Varpa_1458	COG1120	ATPase activity
Varpa_1459	COG2807	transmembrane transport
Varpa_1460	COG2186	Transcriptional regulator
Varpa_1462	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Varpa_1463	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Varpa_1465	COG1280	lysine exporter protein (LysE YggA)
Varpa_1475	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_1480	COG0346	lactoylglutathione lyase activity
Varpa_1490	COG2801	Transposase and inactivated derivatives
Varpa_1491	COG2963	transposase activity
Varpa_1498	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Varpa_1501	COG0165	Argininosuccinate lyase
Varpa_1502	COG3275	phosphorelay sensor kinase activity
Varpa_1505	COG1733	regulation of RNA biosynthetic process
Varpa_1509	COG0583	DNA-binding transcription factor activity
Varpa_1512	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Varpa_1513	COG0181	hydroxymethylbilane synthase activity
Varpa_1518	COG0583	DNA-binding transcription factor activity
Varpa_1519	COG1530	ribonuclease E activity
Varpa_1523	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Varpa_1523	COG0616	signal peptide processing
Varpa_1524	COG2223	nitrite transmembrane transporter activity
Varpa_1525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Varpa_1526	COG0424	maF-like protein
Varpa_1527	COG1399	metal-binding, possibly nucleic acid-binding protein
Varpa_1528	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Varpa_1529	COG0416	fatty acid biosynthetic process
Varpa_1530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Varpa_1532	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1533	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Varpa_1534	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Varpa_1539	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Varpa_1540	COG0481	GTPase activity
Varpa_1541	COG0681	Belongs to the peptidase S26 family
Varpa_1543	COG0571	ribonuclease III activity
Varpa_1544	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Varpa_1545	COG1381	Involved in DNA repair and RecF pathway recombination
Varpa_1546	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Varpa_1547	COG0736	holo-[acyl-carrier-protein] synthase activity
Varpa_1548	COG1472	Belongs to the glycosyl hydrolase 3 family
Varpa_1550	COG1451	nucleotide metabolic process
Varpa_1551	COG0443	Heat shock 70 kDa protein
Varpa_1555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Varpa_1557	COG0762	integral membrane protein
Varpa_1558	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Varpa_1559	COG0159	tryptophan synthase activity
Varpa_1560	COG0133	tryptophan synthase activity
Varpa_1561	COG0135	phosphoribosylanthranilate isomerase activity
Varpa_1562	COG0101	tRNA pseudouridine synthase activity
Varpa_1564	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Varpa_1565	COG0473	3-isopropylmalate dehydrogenase activity
Varpa_1566	COG0066	3-isopropylmalate dehydratase activity
Varpa_1567	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Varpa_1569	COG0372	Belongs to the citrate synthase family
Varpa_1570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Varpa_1571	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Varpa_1572	COG1053	succinate dehydrogenase
Varpa_1575	COG2188	Transcriptional regulator
Varpa_1576	COG0039	L-malate dehydrogenase activity
Varpa_1577	COG4106	trans-aconitate 2-methyltransferase activity
Varpa_1586	COG5295	Hep Hag repeat protein
Varpa_1590	COG1960	acyl-CoA dehydrogenase activity
Varpa_1593	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Varpa_1598	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_1601	COG3483	tryptophan 2,3-dioxygenase activity
Varpa_1604	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Varpa_1606	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Varpa_1607	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Varpa_1609	COG0268	Binds directly to 16S ribosomal RNA
Varpa_1610	COG0728	peptidoglycan biosynthetic process
Varpa_1613	COG3795	YCII-related domain
Varpa_1614	COG3795	YCII-related domain
Varpa_1616	COG4941	Belongs to the sigma-70 factor family
Varpa_1617	COG4977	sequence-specific DNA binding
Varpa_1617	COG1917	Cupin 2, conserved barrel domain protein
Varpa_1621	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Varpa_1622	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Varpa_1623	COG0617	tRNA 3'-terminal CCA addition
Varpa_1625	COG1392	Phosphate transport regulator
Varpa_1626	COG0306	phosphate transporter
Varpa_1629	COG0228	four-way junction DNA binding
Varpa_1630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Varpa_1631	COG0336	Belongs to the RNA methyltransferase TrmD family
Varpa_1632	COG0335	large ribosomal subunit rRNA binding
Varpa_1634	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Varpa_1635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Varpa_1636	COG1162	GTPase activity
Varpa_1637	COG2154	pterin-4-alpha-carbinolamine dehydratase
Varpa_1638	COG0501	Belongs to the peptidase M48B family
Varpa_1639	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Varpa_1640	COG0513	Belongs to the DEAD box helicase family
Varpa_1641	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Varpa_1642	COG1250	3-hydroxyacyl-CoA dehydrogenase
Varpa_1643	COG2267	carboxylic ester hydrolase activity
Varpa_1644	COG3321	synthase
Varpa_1644	COG0604	alcohol dehydrogenase
Varpa_1644	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1649	COG4638	Rieske (2fe-2S)
Varpa_1652	COG0183	Belongs to the thiolase family
Varpa_1654	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Varpa_1655	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1656	COG0683	leucine binding
Varpa_1657	COG0683	leucine binding
Varpa_1658	COG4638	Rieske (2fe-2S)
Varpa_1659	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
Varpa_1662	COG0411	ABC transporter
Varpa_1664	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_1665	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1673	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1675	COG0516	GMP reductase activity
Varpa_1676	COG0210	DNA helicase
Varpa_1680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Varpa_1685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Varpa_1687	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Varpa_1690	COG4773	Receptor
Varpa_1695	COG0412	Dienelactone hydrolase
Varpa_1698	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Varpa_1699	COG4608	Belongs to the ABC transporter superfamily
Varpa_1700	COG0444	Belongs to the ABC transporter superfamily
Varpa_1701	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_1702	COG0601	transmembrane transport
Varpa_1703	COG0747	negative chemotaxis
Varpa_1716	COG3064	Membrane
Varpa_1724	COG1722	exodeoxyribonuclease VII activity
Varpa_1725	COG0142	geranyltranstransferase activity
Varpa_1726	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Varpa_1727	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Varpa_1730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Varpa_1731	COG0477	Major facilitator Superfamily
Varpa_1734	COG3842	ATPase activity
Varpa_1735	COG1840	ABC-type Fe3 transport system, periplasmic component
Varpa_1738	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_1740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_1744	COG2188	Transcriptional regulator
Varpa_1746	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_1761	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Varpa_1761	COG3608	succinylglutamate desuccinylase aspartoacylase
Varpa_1762	COG1320	monovalent cation:proton antiporter activity
Varpa_1763	COG2212	antiporter activity
Varpa_1765	COG0651	ATP synthesis coupled electron transport
Varpa_1766	COG1006	Multisubunit Na H antiporter MnhC subunit
Varpa_1767	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Varpa_1767	COG2111	Na H antiporter
Varpa_1768	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Varpa_1771	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_1773	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Varpa_1778	COG0287	Prephenate dehydrogenase
Varpa_1779	COG1605	Chorismate mutase
Varpa_1779	COG0077	Prephenate dehydratase
Varpa_1780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Varpa_1784	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Varpa_1788	COG4797	methyltransferase
Varpa_1788	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Varpa_1790	COG1187	pseudouridine synthase activity
Varpa_1798	COG3852	Histidine kinase
Varpa_1801	COG0708	Exodeoxyribonuclease III
Varpa_1804	COG4948	Mandelate Racemase Muconate Lactonizing
Varpa_1805	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_1807	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Varpa_1808	COG0583	DNA-binding transcription factor activity
Varpa_1810	COG0392	lysyltransferase activity
Varpa_1814	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Varpa_1818	COG0277	FAD linked oxidase domain protein
Varpa_1820	COG1295	ribonuclease BN
Varpa_1822	COG3118	belongs to the thioredoxin family
Varpa_1824	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_1829	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Varpa_1830	COG0583	DNA-binding transcription factor activity
Varpa_1841	COG3468	outer membrane autotransporter barrel domain protein
Varpa_1851	COG0477	Major facilitator Superfamily
Varpa_1852	COG4566	intracellular signal transduction
Varpa_1854	COG1538	Outer membrane efflux protein
Varpa_1857	COG1309	transcriptional regulator
Varpa_1860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Varpa_1863	COG0431	NADPH-dependent FMN reductase
Varpa_1865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Varpa_1866	COG0640	Transcriptional regulator
Varpa_1869	COG3070	regulator of competence-specific genes
Varpa_1870	COG0346	lactoylglutathione lyase activity
Varpa_1872	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Varpa_1875	COG0625	glutathione transferase activity
Varpa_1878	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Varpa_1879	COG2719	SpoVR family
Varpa_1880	COG2718	Belongs to the UPF0229 family
Varpa_1881	COG2766	serine protein kinase
Varpa_1882	COG0484	heat shock protein binding
Varpa_1883	COG0443	Heat shock 70 kDa protein
Varpa_1884	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Varpa_1887	COG0688	phosphatidylethanolamine metabolic process
Varpa_1889	COG2706	6-phosphogluconolactonase activity
Varpa_1892	COG2721	sulfolactate sulfo-lyase activity
Varpa_1893	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Varpa_1895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_1897	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Varpa_1898	COG2186	Transcriptional regulator
Varpa_1899	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_1900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Varpa_1902	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_1905	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_1909	COG0842	Transport permease protein
Varpa_1910	COG0842	Transport permease protein
Varpa_1911	COG1131	(ABC) transporter
Varpa_1914	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_1916	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Varpa_1918	COG1802	Transcriptional regulator
Varpa_1925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Varpa_1928	COG0583	DNA-binding transcription factor activity
Varpa_1929	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Varpa_1930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_1934	COG2814	Major facilitator Superfamily
Varpa_1936	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Varpa_1938	COG1959	2 iron, 2 sulfur cluster binding
Varpa_1938	COG1295	ribonuclease BN
Varpa_1941	COG0123	including yeast histone deacetylase and acetoin utilization protein
Varpa_1942	COG0824	Thioesterase
Varpa_1944	COG3237	CsbD-like
Varpa_1945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Varpa_1947	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Varpa_1952	COG1309	transcriptional regulator
Varpa_1953	COG1611	Belongs to the LOG family
Varpa_1954	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Varpa_1957	COG0405	Gamma-glutamyltransferase
Varpa_1958	COG0322	excinuclease ABC activity
Varpa_1961	COG0583	DNA-binding transcription factor activity
Varpa_1962	COG0596	Alpha beta hydrolase
Varpa_1963	COG0473	3-isopropylmalate dehydrogenase activity
Varpa_2004	COG2197	response regulator
Varpa_2005	COG0596	Alpha beta hydrolase
Varpa_2006	COG2205	protein histidine kinase activity
Varpa_2048	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Varpa_2049	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Varpa_2052	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Varpa_2054	COG3193	protein, possibly involved in utilization of glycolate and propanediol
Varpa_2060	COG3128	pkhd-type hydroxylase
Varpa_2061	COG4774	siderophore transport
Varpa_2062	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Varpa_2063	COG1477	protein flavinylation
Varpa_2070	COG4771	TonB-dependent receptor
Varpa_2071	COG3720	iron ion transport
Varpa_2074	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Varpa_2075	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Varpa_2076	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Varpa_2079	COG0360	Binds together with S18 to 16S ribosomal RNA
Varpa_2080	COG2965	DNA replication, synthesis of RNA primer
Varpa_2081	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Varpa_2082	COG0359	binds to the 23S rRNA
Varpa_2083	COG0305	Participates in initiation and elongation during chromosome replication
Varpa_2089	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Varpa_2090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Varpa_2092	COG0436	Aminotransferase
Varpa_2095	COG1763	Mo-molybdopterin cofactor biosynthetic process
Varpa_2096	COG0303	'Molybdopterin
Varpa_2098	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Varpa_2099	COG0314	molybdopterin synthase activity
Varpa_2101	COG0542	response to heat
Varpa_2103	COG1022	Amp-dependent synthetase and ligase
Varpa_2104	COG0410	ABC transporter
Varpa_2109	COG1309	transcriptional regulator
Varpa_2110	COG0183	Belongs to the thiolase family
Varpa_2117	COG3842	ATPase activity
Varpa_2118	COG2272	Belongs to the type-B carboxylesterase lipase family
Varpa_2119	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_2120	COG1024	Enoyl-CoA hydratase
Varpa_2124	COG0583	DNA-binding transcription factor activity
Varpa_2129	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Varpa_2130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Varpa_2136	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_2137	COG4974	Belongs to the 'phage' integrase family
Varpa_2138	COG0583	DNA-binding transcription factor activity
Varpa_2139	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Varpa_2140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Varpa_2144	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_2147	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_2149	COG0183	Belongs to the thiolase family
Varpa_2152	COG2833	Protein of unknown function (DUF455)
Varpa_2154	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Varpa_2158	COG2831	hemolysin activation secretion protein
Varpa_2161	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2165	COG3201	nicotinamide mononucleotide transporter
Varpa_2166	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Varpa_2167	COG0148	phosphopyruvate hydratase activity
Varpa_2169	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Varpa_2169	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Varpa_2170	COG0504	CTP synthase activity
Varpa_2171	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Varpa_2173	COG0756	dUTP diphosphatase activity
Varpa_2175	COG1047	Peptidyl-prolyl cis-trans
Varpa_2176	COG2850	peptidyl-arginine hydroxylation
Varpa_2179	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Varpa_2180	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Varpa_2181	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Varpa_2185	COG0187	DNA topoisomerase II activity
Varpa_2186	COG1196	nuclear chromosome segregation
Varpa_2186	COG0739	heme binding
Varpa_2186	COG0741	lytic transglycosylase activity
Varpa_2195	COG0765	amino acid transport
Varpa_2196	COG0765	amino acid transport
Varpa_2198	COG1126	abc transporter atp-binding protein
Varpa_2200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Varpa_2202	COG1609	Transcriptional regulator
Varpa_2206	COG0583	DNA-binding transcription factor activity
Varpa_2209	COG1305	Transglutaminase-like
Varpa_2214	COG1024	Enoyl-CoA hydratase
Varpa_2215	COG2308	Evidence 4 Homologs of previously reported genes of
Varpa_2219	COG2194	sulfuric ester hydrolase activity
Varpa_2221	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Varpa_2224	COG3842	ATPase activity
Varpa_2225	COG3842	ATPase activity
Varpa_2227	COG0395	ABC-type sugar transport system, permease component
Varpa_2234	COG1131	(ABC) transporter
Varpa_2240	COG2951	lytic endotransglycosylase activity
Varpa_2243	COG0714	Associated with various cellular activities
Varpa_2245	COG1511	domain protein
Varpa_2245	COG3264	Mechanosensitive ion channel
Varpa_2248	COG1960	acyl-CoA dehydrogenase activity
Varpa_2252	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_2254	COG2030	dehydratase
Varpa_2256	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2257	COG1024	Enoyl-CoA hydratase
Varpa_2262	COG3795	YCII-related domain
Varpa_2264	COG0477	Major facilitator Superfamily
Varpa_2266	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Varpa_2275	COG3386	PFAM SMP-30 Gluconolaconase
Varpa_2276	COG1609	Transcriptional regulator
Varpa_2277	COG1063	alcohol dehydrogenase
Varpa_2278	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Varpa_2279	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2280	COG2084	Dehydrogenase
Varpa_2286	COG0642	Histidine kinase
Varpa_2287	COG0745	RESPONSE REGULATOR receiver
Varpa_2290	COG0745	RESPONSE REGULATOR receiver
Varpa_2292	COG1414	Transcriptional regulator
Varpa_2293	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Varpa_2294	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Varpa_2295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Varpa_2297	COG2814	Major facilitator Superfamily
Varpa_2300	COG0477	Major facilitator Superfamily
Varpa_2304	COG0596	Alpha beta hydrolase
Varpa_2317	COG2963	transposase activity
Varpa_2321	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Varpa_2330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Varpa_2330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Varpa_2331	COG0509	glycine decarboxylation via glycine cleavage system
Varpa_2332	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Varpa_2338	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_2340	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2342	COG0824	Thioesterase
Varpa_2344	COG0642	Histidine kinase
Varpa_2345	COG0745	RESPONSE REGULATOR receiver
Varpa_2347	COG0671	phosphoesterase, PA-phosphatase related
Varpa_2359	COG4302	ethanolamine ammonia-lyase activity
Varpa_2360	COG4303	Ethanolamine ammonia lyase large subunit
Varpa_2361	COG0531	amino acid
Varpa_2362	COG0545	Peptidyl-prolyl cis-trans isomerase
Varpa_2363	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2364	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Varpa_2379	COG2197	response regulator
Varpa_2383	COG0436	Aminotransferase
Varpa_2390	COG1024	Enoyl-CoA hydratase
Varpa_2395	COG0583	DNA-binding transcription factor activity
Varpa_2396	COG0583	DNA-binding transcription factor activity
Varpa_2397	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Varpa_2402	COG2818	Glycosylase
Varpa_2404	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Varpa_2409	COG0625	glutathione transferase activity
Varpa_2410	COG1183	phosphatidylcholine synthase activity
Varpa_2411	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Varpa_2411	COG0519	Catalyzes the synthesis of GMP from XMP
Varpa_2414	COG0640	Transcriptional regulator
Varpa_2416	COG1272	protein, Hemolysin III
Varpa_2418	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_2421	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Varpa_2422	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_2424	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Varpa_2426	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Varpa_2430	COG1309	transcriptional regulator
Varpa_2432	COG1132	(ABC) transporter
Varpa_2434	COG3384	dioxygenase
Varpa_2436	COG3038	cytochrome b561
Varpa_2441	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Varpa_2442	COG0587	DNA-directed DNA polymerase activity
Varpa_2448	COG0583	DNA-binding transcription factor activity
Varpa_2450	COG0583	DNA-binding transcription factor activity
Varpa_2451	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_2453	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_2454	COG2272	Belongs to the type-B carboxylesterase lipase family
Varpa_2456	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Varpa_2456	COG0674	pyruvate-flavodoxin oxidoreductase activity
Varpa_2459	COG1309	transcriptional regulator
Varpa_2460	COG0604	alcohol dehydrogenase
Varpa_2467	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Varpa_2468	COG2146	nitrite reductase [NAD(P)H] activity
Varpa_2469	COG2116	formate transmembrane transporter activity
Varpa_2470	COG0515	serine threonine protein kinase
Varpa_2470	COG2815	serine threonine protein kinase
Varpa_2482	COG0625	glutathione transferase activity
Varpa_2484	COG3634	alkyl hydroperoxide reductase activity
Varpa_2488	COG0248	Ppx GppA phosphatase
Varpa_2489	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Varpa_2490	COG0573	inorganic phosphate transmembrane transporter activity
Varpa_2491	COG0581	inorganic phosphate transmembrane transporter activity
Varpa_2492	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Varpa_2495	COG5002	protein histidine kinase activity
Varpa_2496	COG0534	Mate efflux family protein
Varpa_2498	COG0254	rRNA binding
Varpa_2499	COG0673	inositol 2-dehydrogenase activity
Varpa_2500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Varpa_2503	COG1074	ATP-dependent DNA helicase activity
Varpa_2505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Varpa_2506	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Varpa_2507	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Varpa_2509	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_2511	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_2512	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Varpa_2512	COG0475	glutathione-regulated potassium exporter activity
Varpa_2513	COG0741	lytic transglycosylase activity
Varpa_2513	COG1388	LysM domain
Varpa_2514	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Varpa_2515	COG2226	methyltransferase
Varpa_2516	COG0328	RNA-DNA hybrid ribonuclease activity
Varpa_2517	COG0303	'Molybdopterin
Varpa_2518	COG0746	molybdenum cofactor guanylyltransferase activity
Varpa_2519	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Varpa_2524	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_2526	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_2536	COG1522	sequence-specific DNA binding
Varpa_2540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Varpa_2543	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Varpa_2543	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Varpa_2546	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Varpa_2551	COG0028	Belongs to the TPP enzyme family
Varpa_2552	COG0440	acetolactate synthase activity
Varpa_2554	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Varpa_2555	COG1183	phosphatidylcholine synthase activity
Varpa_2556	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Varpa_2557	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Varpa_2559	COG1414	Transcriptional regulator
Varpa_2560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Varpa_2561	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Varpa_2567	COG1414	Transcriptional regulator
Varpa_2568	COG0745	RESPONSE REGULATOR receiver
Varpa_2569	COG0642	Histidine kinase
Varpa_2570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Varpa_2573	COG2197	response regulator
Varpa_2578	COG3384	dioxygenase
Varpa_2580	COG2159	amidohydrolase
Varpa_2581	COG0583	DNA-binding transcription factor activity
Varpa_2593	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2594	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Varpa_2603	COG2022	thiamine diphosphate biosynthetic process
Varpa_2606	COG0351	phosphomethylpyrimidine kinase
Varpa_2608	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Varpa_2611	COG0492	ferredoxin-NADP+ reductase activity
Varpa_2612	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Varpa_2613	COG2895	sulfate adenylyltransferase (ATP) activity
Varpa_2621	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_2622	COG0601	transmembrane transport
Varpa_2623	COG0747	negative chemotaxis
Varpa_2624	COG4172	Belongs to the ABC transporter superfamily
Varpa_2625	COG1446	asparaginase
Varpa_2632	COG0667	Aldo Keto reductase
Varpa_2633	COG0583	DNA-binding transcription factor activity
Varpa_2634	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_2639	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2640	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2642	COG0523	cobalamin synthesis protein
Varpa_2644	COG2188	Transcriptional regulator
Varpa_2645	COG3588	fructose-bisphosphate aldolase
Varpa_2646	COG0427	acetyl-CoA hydrolase
Varpa_2647	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Varpa_2648	COG1879	ABC-type sugar transport system periplasmic component
Varpa_2650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Varpa_2651	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_2655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Varpa_2657	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Varpa_2658	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Varpa_2659	COG0745	RESPONSE REGULATOR receiver
Varpa_2660	COG5002	protein histidine kinase activity
Varpa_2665	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Varpa_2665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_2666	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Varpa_2668	COG0431	NADPH-dependent FMN reductase
Varpa_2670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_2671	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Varpa_2672	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_2673	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_2674	COG1116	anion transmembrane transporter activity
Varpa_2682	COG1045	serine acetyltransferase
Varpa_2684	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Varpa_2685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Varpa_2687	COG3550	peptidyl-serine autophosphorylation
Varpa_2689	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Varpa_2691	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Varpa_2693	COG0450	alkyl hydroperoxide reductase
Varpa_2695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Varpa_2697	COG4208	sulfate ABC transporter
Varpa_2698	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Varpa_2699	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Varpa_2700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Varpa_2702	COG1538	Outer membrane efflux protein
Varpa_2706	COG2226	methyltransferase
Varpa_2707	COG0217	transcriptional regulatory protein
Varpa_2708	COG0151	Belongs to the GarS family
Varpa_2709	COG0408	coproporphyrinogen oxidase activity
Varpa_2710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Varpa_2711	COG0799	negative regulation of ribosome biogenesis
Varpa_2712	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Varpa_2714	COG0424	maF-like protein
Varpa_2715	COG1530	ribonuclease E activity
Varpa_2716	COG1132	(ABC) transporter
Varpa_2717	COG0823	Involved in the tonB-independent uptake of proteins
Varpa_2720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Varpa_2722	COG0582	viral genome integration into host DNA
Varpa_2756	COG1525	nuclease
Varpa_2773	COG0514	ATP-dependent DNA helicase (RecQ)
Varpa_2790	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Varpa_2798	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Varpa_2800	COG0667	Aldo Keto reductase
Varpa_2806	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Varpa_2811	COG2890	protein-(glutamine-N5) methyltransferase activity
Varpa_2812	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Varpa_2814	COG2171	N-acyltransferase activity
Varpa_2817	COG1280	lysine exporter protein (LysE YggA)
Varpa_2818	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Varpa_2818	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Varpa_2820	COG1643	Atp-dependent helicase
Varpa_2824	COG0436	Aminotransferase
Varpa_2825	COG0583	DNA-binding transcription factor activity
Varpa_2827	COG0795	lipopolysaccharide-transporting ATPase activity
Varpa_2829	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Varpa_2839	COG1982	Orn Lys Arg decarboxylase major
Varpa_2840	COG1793	dna ligase
Varpa_2842	COG4166	transmembrane transport
Varpa_2843	COG4174	ABC transporter (Permease)
Varpa_2844	COG4239	(ABC) transporter, permease
Varpa_2845	COG4172	Belongs to the ABC transporter superfamily
Varpa_2846	COG0477	Major facilitator Superfamily
Varpa_2847	COG0779	Required for maturation of 30S ribosomal subunits
Varpa_2848	COG0195	Participates in both transcription termination and antitermination
Varpa_2848	COG2251	uridine kinase activity
Varpa_2849	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Varpa_2850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Varpa_2851	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Varpa_2859	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Varpa_2860	COG2867	negative regulation of translational initiation
Varpa_2866	COG0519	Catalyzes the synthesis of GMP from XMP
Varpa_2866	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Varpa_2869	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Varpa_2872	COG2197	response regulator
Varpa_2874	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Varpa_2875	COG0297	glycogen (starch) synthase activity
Varpa_2881	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Varpa_2882	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Varpa_2883	COG0489	protein tyrosine kinase activity
Varpa_2883	COG3206	protein involved in exopolysaccharide biosynthesis
Varpa_2884	COG1596	polysaccharide export
Varpa_2887	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Varpa_2890	COG2204	response regulator
Varpa_2896	COG3501	Rhs element vgr protein
Varpa_2907	COG3501	Rhs element vgr protein
Varpa_2908	COG3501	Rhs element vgr protein
Varpa_2909	COG3501	Rhs element vgr protein
Varpa_2923	COG0515	serine threonine protein kinase
Varpa_2923	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Varpa_2926	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_2929	COG0583	DNA-binding transcription factor activity
Varpa_2936	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_2941	COG4566	intracellular signal transduction
Varpa_2946	COG0590	tRNA wobble adenosine to inosine editing
Varpa_2947	COG1619	proteins homologs of microcin C7 resistance protein MccF
Varpa_2956	COG5002	protein histidine kinase activity
Varpa_2958	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Varpa_2959	COG4999	Histidine kinase
Varpa_2959	COG3850	Histidine kinase
Varpa_2959	COG3437	response regulator, receiver
Varpa_2959	COG2205	protein histidine kinase activity
Varpa_2960	COG1199	ATP-dependent helicase activity
Varpa_2960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Varpa_2968	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Varpa_2971	COG0667	Aldo Keto reductase
Varpa_2972	COG2207	Transcriptional regulator
Varpa_2973	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Varpa_2974	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Varpa_2975	COG2814	Major facilitator Superfamily
Varpa_2978	COG0667	Aldo Keto reductase
Varpa_2979	COG3360	Dodecin
Varpa_2988	COG0045	succinate-CoA ligase (ADP-forming) activity
Varpa_2988	COG1042	CoA-binding domain protein
Varpa_2988	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Varpa_2994	COG2197	response regulator
Varpa_2997	COG1793	dna ligase
Varpa_3003	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Varpa_3004	COG0366	Alpha amylase catalytic
Varpa_3005	COG0366	Alpha amylase catalytic
Varpa_3008	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Varpa_3009	COG1640	4-alpha-glucanotransferase
Varpa_3015	COG2205	protein histidine kinase activity
Varpa_3021	COG2249	NAD(P)H dehydrogenase (quinone) activity
Varpa_3025	COG1063	alcohol dehydrogenase
Varpa_3031	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3035	COG1294	oxidase, subunit
Varpa_3036	COG1271	oxidase subunit
Varpa_3041	COG1132	(ABC) transporter
Varpa_3042	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Varpa_3046	COG2155	Conserved Protein
Varpa_3051	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Varpa_3055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Varpa_3057	COG0673	inositol 2-dehydrogenase activity
Varpa_3062	COG0500	methyltransferase
Varpa_3065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Varpa_3067	COG2204	response regulator
Varpa_3069	COG2201	protein-glutamate methylesterase activity
Varpa_3071	COG3546	catalase activity
Varpa_3072	COG1058	Belongs to the CinA family
Varpa_3072	COG1546	Belongs to the CinA family
Varpa_3074	COG0492	ferredoxin-NADP+ reductase activity
Varpa_3084	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3086	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3093	COG3685	Protein conserved in bacteria
Varpa_3094	COG0596	Alpha beta hydrolase
Varpa_3100	COG0084	hydrolase, TatD family'
Varpa_3103	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Varpa_3104	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Varpa_3105	COG0354	folic acid binding
Varpa_3111	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Varpa_3114	COG2183	response to ionizing radiation
Varpa_3115	COG4585	Histidine kinase
Varpa_3116	COG2201	protein-glutamate methylesterase activity
Varpa_3123	COG0534	Mate efflux family protein
Varpa_3125	COG4774	siderophore transport
Varpa_3126	COG3712	iron ion homeostasis
Varpa_3127	COG1595	DNA-templated transcription, initiation
Varpa_3128	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Varpa_3129	COG1609	Transcriptional regulator
Varpa_3130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Varpa_3132	COG0477	Major facilitator Superfamily
Varpa_3134	COG3008	intermembrane lipid transfer
Varpa_3134	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Varpa_3135	COG2995	paraquat-inducible protein a
Varpa_3136	COG2995	paraquat-inducible protein a
Varpa_3137	COG2814	Major facilitator Superfamily
Varpa_3138	COG2814	Major facilitator Superfamily
Varpa_3143	COG1360	Flagellar Motor Protein
Varpa_3148	COG0583	DNA-binding transcription factor activity
Varpa_3150	COG0583	DNA-binding transcription factor activity
Varpa_3156	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Varpa_3157	COG0477	Major facilitator Superfamily
Varpa_3158	COG0247	lactate metabolic process
Varpa_3158	COG0277	FAD linked oxidase domain protein
Varpa_3163	COG0583	DNA-binding transcription factor activity
Varpa_3164	COG2814	Major facilitator Superfamily
Varpa_3168	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Varpa_3176	COG1960	acyl-CoA dehydrogenase activity
Varpa_3177	COG2130	NADP-dependent
Varpa_3182	COG1960	acyl-CoA dehydrogenase activity
Varpa_3184	COG0183	Belongs to the thiolase family
Varpa_3185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Varpa_3186	COG1024	Enoyl-CoA hydratase
Varpa_3186	COG1250	3-hydroxyacyl-CoA dehydrogenase
Varpa_3188	COG0411	ABC transporter
Varpa_3193	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_3196	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Varpa_3197	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Varpa_3198	COG2917	probably involved in intracellular septation
Varpa_3200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Varpa_3201	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Varpa_3201	COG0047	phosphoribosylformylglycinamidine synthase activity
Varpa_3202	COG0024	Methionine aminopeptidase
Varpa_3204	COG2203	Gaf domain
Varpa_3204	COG2199	diguanylate cyclase activity
Varpa_3207	COG2894	cell division
Varpa_3208	COG1215	transferase activity, transferring glycosyl groups
Varpa_3209	COG1215	transferase activity, transferring glycosyl groups
Varpa_3210	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Varpa_3211	COG0457	Tetratricopeptide repeat
Varpa_3216	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Varpa_3217	COG0765	amino acid transport
Varpa_3218	COG4597	amino acid ABC transporter
Varpa_3219	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Varpa_3221	COG0242	peptide deformylase activity
Varpa_3223	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Varpa_3225	COG1196	nuclear chromosome segregation
Varpa_3228	COG3550	peptidyl-serine autophosphorylation
Varpa_3237	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Varpa_3240	COG0433	COG0433 Predicted ATPase
Varpa_3242	COG1595	DNA-templated transcription, initiation
Varpa_3247	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Varpa_3248	COG1744	ABC transporter substrate-binding protein PnrA-like
Varpa_3249	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Varpa_3256	COG0529	Catalyzes the synthesis of activated sulfate
Varpa_3257	COG0402	S-adenosylhomocysteine deaminase activity
Varpa_3261	COG2925	Exonuclease
Varpa_3263	COG0542	response to heat
Varpa_3264	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Varpa_3271	COG2885	chlorophyll binding
Varpa_3271	COG3047	cAMP biosynthetic process
Varpa_3282	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Varpa_3283	COG1570	exodeoxyribonuclease VII activity
Varpa_3284	COG0811	peptide transport
Varpa_3285	COG0848	biopolymer transport protein
Varpa_3286	COG1663	tetraacyldisaccharide 4'-kinase activity
Varpa_3287	COG2835	tetraacyldisaccharide 4'-kinase activity
Varpa_3288	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Varpa_3289	COG0563	adenylate kinase activity
Varpa_3290	COG0252	asparaginase activity
Varpa_3291	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Varpa_3293	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Varpa_3294	COG2814	Major facilitator Superfamily
Varpa_3295	COG1250	3-hydroxyacyl-CoA dehydrogenase
Varpa_3296	COG1024	Enoyl-CoA hydratase
Varpa_3297	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Varpa_3301	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Varpa_3303	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Varpa_3304	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Varpa_3305	COG1534	Rna-binding protein
Varpa_3308	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Varpa_3310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Varpa_3311	COG0505	Belongs to the CarA family
Varpa_3312	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Varpa_3313	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Varpa_3314	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Varpa_3315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Varpa_3316	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Varpa_3317	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Varpa_3319	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Varpa_3320	COG0750	zinc metalloprotease
Varpa_3321	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Varpa_3322	COG0575	Belongs to the CDS family
Varpa_3324	COG0233	cytoplasmic translational termination
Varpa_3325	COG0528	UMP kinase activity
Varpa_3326	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Varpa_3327	COG0052	Belongs to the universal ribosomal protein uS2 family
Varpa_3331	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Varpa_3331	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Varpa_3332	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3333	COG0557	exoribonuclease II activity
Varpa_3334	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Varpa_3335	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Varpa_3336	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Varpa_3338	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3340	COG0745	RESPONSE REGULATOR receiver
Varpa_3341	COG2205	protein histidine kinase activity
Varpa_3342	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Varpa_3342	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Varpa_3343	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Varpa_3343	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Varpa_3344	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Varpa_3345	COG0560	Phosphoserine phosphatase
Varpa_3349	COG3712	iron ion homeostasis
Varpa_3351	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_3352	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Varpa_3355	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Varpa_3356	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Varpa_3357	COG1492	cobalamin metabolic process
Varpa_3359	COG1538	Outer membrane efflux protein
Varpa_3361	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Varpa_3365	COG1346	cytolysis
Varpa_3372	COG0778	Nitroreductase
Varpa_3373	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Varpa_3374	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Varpa_3375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Varpa_3378	COG1797	cobyrinic acid a,c-diamide synthase activity
Varpa_3382	COG0730	response to heat
Varpa_3385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Varpa_3391	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_3392	COG1024	Enoyl-CoA hydratase
Varpa_3395	COG1802	Transcriptional regulator
Varpa_3396	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Varpa_3399	COG0583	DNA-binding transcription factor activity
Varpa_3400	COG0583	DNA-binding transcription factor activity
Varpa_3401	COG0129	dihydroxy-acid dehydratase activity
Varpa_3404	COG4654	Cytochrome c, class I
Varpa_3406	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Varpa_3408	COG0583	DNA-binding transcription factor activity
Varpa_3409	COG2910	NAD(P)H-binding
Varpa_3410	COG0114	fumarate hydratase activity
Varpa_3412	COG4176	ABC-type proline glycine betaine transport system permease component
Varpa_3413	COG2113	Glycine betaine
Varpa_3415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Varpa_3420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Varpa_3421	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Varpa_3422	COG0740	serine-type endopeptidase activity
Varpa_3423	COG0544	peptidyl-prolyl cis-trans isomerase activity
Varpa_3425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Varpa_3428	COG1562	ergosterol biosynthetic process
Varpa_3430	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Varpa_3432	COG1280	lysine exporter protein (LysE YggA)
Varpa_3434	COG1011	Hydrolase
Varpa_3435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Varpa_3441	COG0410	ABC transporter
Varpa_3443	COG0411	ABC transporter
Varpa_3457	COG0642	Histidine kinase
Varpa_3458	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Varpa_3459	COG2326	polyphosphate kinase activity
Varpa_3462	COG4654	Cytochrome c, class I
Varpa_3468	COG0747	negative chemotaxis
Varpa_3469	COG0601	transmembrane transport
Varpa_3470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_3472	COG0154	amidase activity
Varpa_3474	COG3204	pilus organization
Varpa_3475	COG0410	ABC transporter
Varpa_3477	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_3478	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_3480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Varpa_3481	COG0431	NADPH-dependent FMN reductase
Varpa_3487	COG1175	transmembrane transport
Varpa_3490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Varpa_3492	COG3829	transcription factor binding
Varpa_3498	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Varpa_3501	COG0527	aspartate kinase activity
Varpa_3502	COG0037	tRNA processing
Varpa_3503	COG0825	malonyl-CoA metabolic process
Varpa_3505	COG0215	cysteine-tRNA ligase activity
Varpa_3508	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Varpa_3509	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Varpa_3513	COG0741	lytic transglycosylase activity
Varpa_3514	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Varpa_3515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Varpa_3522	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Varpa_3522	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Varpa_3525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Varpa_3526	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Varpa_3527	COG0436	Aminotransferase
Varpa_3528	COG0824	Thioesterase
Varpa_3530	COG0848	biopolymer transport protein
Varpa_3534	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Varpa_3534	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Varpa_3539	COG0642	Histidine kinase
Varpa_3543	COG1741	Belongs to the pirin family
Varpa_3545	COG2259	Doxx family
Varpa_3546	COG1741	Belongs to the pirin family
Varpa_3549	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Varpa_3550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Varpa_3553	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Varpa_3562	COG0410	ABC transporter
Varpa_3563	COG3842	ATPase activity
Varpa_3567	COG0784	Response regulator, receiver
Varpa_3567	COG2198	Histidine kinase
Varpa_3567	COG2205	protein histidine kinase activity
Varpa_3568	COG3437	response regulator, receiver
Varpa_3571	COG0583	DNA-binding transcription factor activity
Varpa_3574	COG0784	Response regulator, receiver
Varpa_3575	COG4251	negative regulation of phosphorylation
Varpa_3579	COG0308	aminopeptidase N
Varpa_3580	COG2271	Major facilitator Superfamily
Varpa_3589	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Varpa_3590	COG0028	Belongs to the TPP enzyme family
Varpa_3591	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3592	COG1414	Transcriptional regulator
Varpa_3596	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_3597	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_3598	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Varpa_3599	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Varpa_3601	COG1850	ribulose-bisphosphate carboxylase activity
Varpa_3603	COG3954	Phosphoribulokinase
Varpa_3604	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Varpa_3605	COG0784	Response regulator, receiver
Varpa_3605	COG2205	protein histidine kinase activity
Varpa_3610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Varpa_3611	COG3383	formate dehydrogenase (NAD+) activity
Varpa_3618	COG0243	molybdopterin cofactor binding
Varpa_3618	COG3383	formate dehydrogenase (NAD+) activity
Varpa_3619	COG0437	4 iron, 4 sulfur cluster binding
Varpa_3623	COG0303	'Molybdopterin
Varpa_3624	COG0303	'Molybdopterin
Varpa_3627	COG0776	regulation of translation
Varpa_3641	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_3653	COG1024	Enoyl-CoA hydratase
Varpa_3657	COG1522	sequence-specific DNA binding
Varpa_3658	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3665	COG0456	acetyltransferase
Varpa_3665	COG1846	Transcriptional regulator
Varpa_3666	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3667	COG4689	acetoacetate decarboxylase
Varpa_3671	COG1295	ribonuclease BN
Varpa_3673	COG2059	Chromate
Varpa_3674	COG0667	Aldo Keto reductase
Varpa_3680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Varpa_3683	COG4181	ATPase activity
Varpa_3687	COG0626	cystathionine gamma-synthase activity
Varpa_3692	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Varpa_3693	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Varpa_3695	COG0330	HflC and HflK could
Varpa_3696	COG0330	HflC and HflK could
Varpa_3697	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Varpa_3698	COG1923	regulation of RNA biosynthetic process
Varpa_3699	COG1160	GTP binding
Varpa_3702	COG0124	histidyl-tRNA synthetase
Varpa_3703	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Varpa_3706	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Varpa_3707	COG0105	UTP biosynthetic process
Varpa_3708	COG1187	pseudouridine synthase activity
Varpa_3709	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Varpa_3710	COG0564	pseudouridine synthase activity
Varpa_3712	COG1199	ATP-dependent helicase activity
Varpa_3716	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Varpa_3717	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Varpa_3718	COG0508	dehydrogenase complex catalyzes the overall conversion of
Varpa_3719	COG0567	Dehydrogenase, E1 component
Varpa_3725	COG2133	pyrroloquinoline quinone binding
Varpa_3726	COG0791	NLP P60 protein
Varpa_3727	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Varpa_3728	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Varpa_3729	COG0508	dehydrogenase complex catalyzes the overall conversion of
Varpa_3730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Varpa_3732	COG4566	intracellular signal transduction
Varpa_3733	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Varpa_3736	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Varpa_3737	COG0167	dihydroorotate dehydrogenase activity
Varpa_3740	COG0579	oxidoreductase
Varpa_3744	COG0633	Ferredoxin
Varpa_3745	COG0443	Heat shock 70 kDa protein
Varpa_3746	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Varpa_3748	COG0822	iron-sulfur transferase activity
Varpa_3749	COG1104	cysteine desulfurase activity
Varpa_3750	COG1959	2 iron, 2 sulfur cluster binding
Varpa_3754	COG2878	Part of a membrane complex involved in electron transport
Varpa_3756	COG0697	spore germination
Varpa_3757	COG1522	sequence-specific DNA binding
Varpa_3759	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Varpa_3760	COG0439	Biotin carboxylase
Varpa_3761	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Varpa_3762	COG1703	isobutyryl-CoA mutase activity
Varpa_3766	COG1802	Transcriptional regulator
Varpa_3768	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Varpa_3769	COG0784	Response regulator, receiver
Varpa_3769	COG2198	Histidine kinase
Varpa_3769	COG5002	protein histidine kinase activity
Varpa_3774	COG1846	Transcriptional regulator
Varpa_3776	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3777	COG1309	transcriptional regulator
Varpa_3779	COG0028	Belongs to the TPP enzyme family
Varpa_3780	COG1522	sequence-specific DNA binding
Varpa_3789	COG2197	response regulator
Varpa_3798	COG2814	Major facilitator Superfamily
Varpa_3810	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_3811	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3812	COG0179	Fumarylacetoacetate (FAA) hydrolase
Varpa_3814	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Varpa_3819	COG2249	NAD(P)H dehydrogenase (quinone) activity
Varpa_3821	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_3824	COG0583	DNA-binding transcription factor activity
Varpa_3826	COG1609	Transcriptional regulator
Varpa_3828	COG1879	ABC-type sugar transport system periplasmic component
Varpa_3829	COG1733	regulation of RNA biosynthetic process
Varpa_3838	COG1793	dna ligase
Varpa_3841	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Varpa_3851	COG4774	siderophore transport
Varpa_3854	COG4651	solute:proton antiporter activity
Varpa_3854	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Varpa_3855	COG1301	dicarboxylic acid transport
Varpa_3856	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_3858	COG1546	Belongs to the CinA family
Varpa_3858	COG1058	Belongs to the CinA family
Varpa_3861	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_3862	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Varpa_3864	COG0583	DNA-binding transcription factor activity
Varpa_3865	COG0625	glutathione transferase activity
Varpa_3867	COG0183	Belongs to the thiolase family
Varpa_3868	COG3243	poly(R)-hydroxyalkanoic acid synthase
Varpa_3875	COG3045	CreA protein
Varpa_3877	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_3881	COG1132	(ABC) transporter
Varpa_3882	COG1609	Transcriptional regulator
Varpa_3883	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Varpa_3884	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Varpa_3886	COG1850	ribulose-bisphosphate carboxylase activity
Varpa_3895	COG3042	response to heat
Varpa_3903	COG1024	Enoyl-CoA hydratase
Varpa_3905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Varpa_3910	COG2963	transposase activity
Varpa_3917	COG2801	Transposase and inactivated derivatives
Varpa_3922	COG2801	Transposase and inactivated derivatives
Varpa_3931	COG2831	hemolysin activation secretion protein
Varpa_3933	COG3210	domain, Protein
Varpa_3942	COG0776	regulation of translation
Varpa_3943	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Varpa_3943	COG0072	phenylalanine-tRNA ligase activity
Varpa_3944	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Varpa_3945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Varpa_3946	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Varpa_3947	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Varpa_3948	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Varpa_3955	COG0028	Belongs to the TPP enzyme family
Varpa_3956	COG1309	transcriptional regulator
Varpa_3958	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_3959	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_3962	COG0673	inositol 2-dehydrogenase activity
Varpa_3965	COG3214	Protein conserved in bacteria
Varpa_3966	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Varpa_3970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Varpa_3971	COG0802	atpase or kinase
Varpa_3972	COG0860	N-Acetylmuramoyl-L-alanine amidase
Varpa_3974	COG0586	Pfam SNARE associated Golgi protein
Varpa_3976	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Varpa_3981	COG2207	Transcriptional regulator
Varpa_3982	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Varpa_3983	COG4181	ATPase activity
Varpa_3985	COG2186	Transcriptional regulator
Varpa_3988	COG3795	YCII-related domain
Varpa_3989	COG4941	Belongs to the sigma-70 factor family
Varpa_3990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Varpa_3998	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_4004	COG2814	Major facilitator Superfamily
Varpa_4005	COG1566	PFAM secretion protein HlyD family protein
Varpa_4006	COG1538	Outer membrane efflux protein
Varpa_4007	COG1846	Transcriptional regulator
Varpa_4008	COG1132	(ABC) transporter
Varpa_4010	COG0494	nUDIX hydrolase
Varpa_4012	COG1007	ATP synthesis coupled electron transport
Varpa_4015	COG0713	ATP synthesis coupled electron transport
Varpa_4017	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Varpa_4018	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Varpa_4019	COG1034	ATP synthesis coupled electron transport
Varpa_4022	COG0649	NAD binding
Varpa_4023	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Varpa_4024	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Varpa_4025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Varpa_4027	COG0149	triose-phosphate isomerase activity
Varpa_4029	COG1185	polyribonucleotide nucleotidyltransferase activity
Varpa_4030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Varpa_4031	COG0697	spore germination
Varpa_4033	COG0683	leucine binding
Varpa_4035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Varpa_4036	COG3707	response regulator
Varpa_4037	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_4038	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_4039	COG1116	anion transmembrane transporter activity
Varpa_4041	COG2223	nitrite transmembrane transporter activity
Varpa_4042	COG0515	serine threonine protein kinase
Varpa_4042	COG2815	serine threonine protein kinase
Varpa_4043	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Varpa_4045	COG0243	molybdopterin cofactor binding
Varpa_4047	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Varpa_4052	COG1176	ABC-type spermidine putrescine transport system, permease component I
Varpa_4053	COG3833	ABC-type maltose transport systems, permease component
Varpa_4055	COG0791	NLP P60 protein
Varpa_4056	COG2081	HI0933 family
Varpa_4057	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Varpa_4059	COG0494	nUDIX hydrolase
Varpa_4063	COG0385	Bile acid
Varpa_4064	COG2072	flavoprotein involved in K transport
Varpa_4065	COG0300	oxidoreductase activity
Varpa_4066	COG1063	alcohol dehydrogenase
Varpa_4067	COG3842	ATPase activity
Varpa_4068	COG0395	ABC-type sugar transport system, permease component
Varpa_4071	COG2814	Major facilitator Superfamily
Varpa_4073	COG0312	modulator of DNA gyrase
Varpa_4074	COG3028	Belongs to the UPF0307 family
Varpa_4075	COG0521	Mo-molybdopterin cofactor biosynthetic process
Varpa_4084	COG0475	glutathione-regulated potassium exporter activity
Varpa_4095	COG0789	Transcriptional regulator
Varpa_4100	COG1045	serine acetyltransferase
Varpa_4103	COG1289	transmembrane transporter activity
Varpa_4107	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Varpa_4108	COG2207	Transcriptional regulator
Varpa_4111	COG2258	MOSC domain
Varpa_4117	COG3119	arylsulfatase activity
Varpa_4122	COG0747	negative chemotaxis
Varpa_4123	COG0601	transmembrane transport
Varpa_4124	COG4171	peptide transport system, permease
Varpa_4130	COG1695	Transcriptional regulator
Varpa_4131	COG2375	cellular response to nickel ion
Varpa_4132	COG0598	Magnesium transport protein CorA
Varpa_4134	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Varpa_4138	COG4941	Belongs to the sigma-70 factor family
Varpa_4139	COG3795	YCII-related domain
Varpa_4140	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_4143	COG4585	Histidine kinase
Varpa_4144	COG1968	undecaprenyl-diphosphatase activity
Varpa_4149	COG1538	Outer membrane efflux protein
Varpa_4152	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Varpa_4157	COG3275	phosphorelay sensor kinase activity
Varpa_4160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Varpa_4170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Varpa_4171	COG0004	ammonium transporteR
Varpa_4176	COG4774	siderophore transport
Varpa_4179	COG1131	(ABC) transporter
Varpa_4180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Varpa_4183	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Varpa_4187	COG0789	Transcriptional regulator
Varpa_4189	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_4190	COG2201	protein-glutamate methylesterase activity
Varpa_4191	COG2918	glutathione biosynthetic process
Varpa_4193	COG0400	carboxylic ester hydrolase activity
Varpa_4196	COG0523	cobalamin synthesis protein
Varpa_4197	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_4201	COG0477	Major facilitator Superfamily
Varpa_4208	COG2354	Protein conserved in bacteria
Varpa_4212	COG4628	conserved protein (DUF2132)
Varpa_4215	COG0564	pseudouridine synthase activity
Varpa_4216	COG0589	response to stress
Varpa_4219	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Varpa_4220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Varpa_4221	COG1252	NADH dehydrogenase
Varpa_4225	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_4226	COG1764	response to oxidative stress
Varpa_4230	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_4232	COG2271	Major facilitator Superfamily
Varpa_4235	COG0765	amino acid transport
Varpa_4236	COG0765	amino acid transport
Varpa_4241	COG0584	glycerophosphoryl diester phosphodiesterase
Varpa_4245	COG2132	Multicopper oxidase
Varpa_4250	COG3191	aminopeptidase activity
Varpa_4253	COG0789	Transcriptional regulator
Varpa_4255	COG0488	(ABC) transporter
Varpa_4256	COG0513	Belongs to the DEAD box helicase family
Varpa_4258	COG3842	ATPase activity
Varpa_4260	COG1175	transmembrane transport
Varpa_4262	COG2186	Transcriptional regulator
Varpa_4263	COG0129	dihydroxy-acid dehydratase activity
Varpa_4264	COG3734	2-keto-3-deoxy-galactonokinase
Varpa_4265	COG0800	Aldolase
Varpa_4266	COG0235	Class ii aldolase
Varpa_4273	COG2205	protein histidine kinase activity
Varpa_4274	COG0596	Alpha beta hydrolase
Varpa_4275	COG1840	ABC-type Fe3 transport system, periplasmic component
Varpa_4277	COG3842	ATPase activity
Varpa_4279	COG0346	lactoylglutathione lyase activity
Varpa_4282	COG0800	Aldolase
Varpa_4288	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Varpa_4289	COG0259	pyridoxamine-phosphate oxidase activity
Varpa_4294	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Varpa_4295	COG1309	transcriptional regulator
Varpa_4296	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Varpa_4297	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Varpa_4302	COG2169	Transcriptional regulator
Varpa_4304	COG0697	spore germination
Varpa_4307	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_4310	COG0277	FAD linked oxidase domain protein
Varpa_4313	COG0625	glutathione transferase activity
Varpa_4314	COG2366	antibiotic biosynthetic process
Varpa_4316	COG1538	Outer membrane efflux protein
Varpa_4317	COG1136	(ABC) transporter
Varpa_4317	COG0577	efflux transmembrane transporter activity
Varpa_4318	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Varpa_4323	COG4774	siderophore transport
Varpa_4337	COG0583	DNA-binding transcription factor activity
Varpa_4338	COG2084	Dehydrogenase
Varpa_4340	COG0154	amidase activity
Varpa_4341	COG0747	negative chemotaxis
Varpa_4342	COG4608	Belongs to the ABC transporter superfamily
Varpa_4343	COG0444	Belongs to the ABC transporter superfamily
Varpa_4344	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_4346	COG0473	3-isopropylmalate dehydrogenase activity
Varpa_4348	COG1960	acyl-CoA dehydrogenase activity
Varpa_4349	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_4351	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Varpa_4356	COG0285	dihydrofolate synthase activity
Varpa_4357	COG1393	Belongs to the ArsC family
Varpa_4359	COG3123	guanosine phosphorylase activity
Varpa_4360	COG0137	argininosuccinate synthase activity
Varpa_4362	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Varpa_4363	COG1666	GTP binding
Varpa_4365	COG0251	oxidation-reduction process
Varpa_4366	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Varpa_4367	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Varpa_4368	COG0667	Aldo Keto reductase
Varpa_4369	COG2267	carboxylic ester hydrolase activity
Varpa_4375	COG2011	ABC-type metal ion transport system permease component
Varpa_4376	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Varpa_4377	COG1464	Belongs to the NlpA lipoprotein family
Varpa_4379	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Varpa_4380	COG0308	aminopeptidase N
Varpa_4381	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Varpa_4382	COG1403	HNH endonuclease
Varpa_4386	COG0477	Major facilitator Superfamily
Varpa_4398	COG3302	dmso reductase anchor subunit
Varpa_4399	COG0437	4 iron, 4 sulfur cluster binding
Varpa_4400	COG0243	molybdopterin cofactor binding
Varpa_4401	COG0583	DNA-binding transcription factor activity
Varpa_4402	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Varpa_4404	COG1414	Transcriptional regulator
Varpa_4409	COG1012	belongs to the aldehyde dehydrogenase family
Varpa_4410	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_4419	COG1414	Transcriptional regulator
Varpa_4420	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Varpa_4426	COG3046	protein related to deoxyribodipyrimidine photolyase
Varpa_4429	COG0583	DNA-binding transcription factor activity
Varpa_4430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_4432	COG4521	taurine ABC transporter
Varpa_4434	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Varpa_4439	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_4440	COG0444	Belongs to the ABC transporter superfamily
Varpa_4441	COG4608	Belongs to the ABC transporter superfamily
Varpa_4442	COG1228	amidohydrolase
Varpa_4456	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_4463	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Varpa_4464	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Varpa_4466	COG1253	flavin adenine dinucleotide binding
Varpa_4467	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Varpa_4469	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Varpa_4475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Varpa_4477	COG1960	acyl-CoA dehydrogenase activity
Varpa_4478	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_4482	COG0513	Belongs to the DEAD box helicase family
Varpa_4483	COG2321	neutral zinc metallopeptidase
Varpa_4484	COG0717	Belongs to the dCTP deaminase family
Varpa_4485	COG0402	S-adenosylhomocysteine deaminase activity
Varpa_4487	COG4221	oxidoreductase activity
Varpa_4490	COG2366	antibiotic biosynthetic process
Varpa_4491	COG4977	sequence-specific DNA binding
Varpa_4492	COG0583	DNA-binding transcription factor activity
Varpa_4493	COG2814	Major facilitator Superfamily
Varpa_4494	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Varpa_4501	COG2301	Belongs to the HpcH HpaI aldolase family
Varpa_4505	COG3287	FIST C domain
Varpa_4505	COG2200	EAL domain
Varpa_4505	COG2199	diguanylate cyclase activity
Varpa_4511	COG2252	PERMEase
Varpa_4513	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Varpa_4519	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Varpa_4529	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Varpa_4538	COG2351	hydroxyisourate hydrolase activity
Varpa_4539	COG2186	Transcriptional regulator
Varpa_4542	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Varpa_4548	COG3511	phospholipase C
Varpa_4559	COG1953	Uracil, thiamine, allantoin
Varpa_4562	COG2233	PERMEase
Varpa_4563	COG0656	L-ascorbic acid biosynthetic process
Varpa_4565	COG1301	dicarboxylic acid transport
Varpa_4567	COG0628	permease
Varpa_4570	COG0583	DNA-binding transcription factor activity
Varpa_4571	COG3960	tartronate-semialdehyde synthase activity
Varpa_4572	COG3622	Belongs to the hyi family
Varpa_4573	COG2084	Dehydrogenase
Varpa_4582	COG3501	Rhs element vgr protein
Varpa_4584	COG1116	anion transmembrane transporter activity
Varpa_4585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_4589	COG0745	RESPONSE REGULATOR receiver
Varpa_4593	COG1733	regulation of RNA biosynthetic process
Varpa_4596	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Varpa_4598	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Varpa_4599	COG0590	tRNA wobble adenosine to inosine editing
Varpa_4600	COG0829	nickel cation binding
Varpa_4607	COG0583	DNA-binding transcription factor activity
Varpa_4611	COG0626	cystathionine gamma-synthase activity
Varpa_4614	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Varpa_4617	COG2879	small protein
Varpa_4618	COG1966	Carbon starvation protein
Varpa_4619	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Varpa_4620	COG0791	NLP P60 protein
Varpa_4622	COG2207	Transcriptional regulator
Varpa_4627	COG0300	oxidoreductase activity
Varpa_4631	COG3386	PFAM SMP-30 Gluconolaconase
Varpa_4634	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Varpa_4638	COG2814	Major facilitator Superfamily
Varpa_4642	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Varpa_4644	COG1538	Outer membrane efflux protein
Varpa_4645	COG0667	Aldo Keto reductase
Varpa_4646	COG2814	Major facilitator Superfamily
Varpa_4650	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_4653	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Varpa_4654	COG0583	DNA-binding transcription factor activity
Varpa_4657	COG0306	phosphate transporter
Varpa_4659	COG0613	PHP domain protein
Varpa_4661	COG0009	L-threonylcarbamoyladenylate synthase
Varpa_4662	COG1994	Peptidase M50
Varpa_4663	COG0180	Tryptophanyl-tRNA synthetase
Varpa_4664	COG2197	response regulator
Varpa_4667	COG1950	PFAM Membrane protein of
Varpa_4671	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Varpa_4674	COG3206	protein involved in exopolysaccharide biosynthesis
Varpa_4674	COG0489	protein tyrosine kinase activity
Varpa_4675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Varpa_4678	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Varpa_4681	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Varpa_4682	COG0438	transferase activity, transferring glycosyl groups
Varpa_4689	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Varpa_4690	COG1596	polysaccharide export
Varpa_4691	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Varpa_4692	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Varpa_4693	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Varpa_4694	COG1047	Peptidyl-prolyl cis-trans
Varpa_4695	COG2003	Belongs to the UPF0758 family
Varpa_4699	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Varpa_4701	COG0765	amino acid transport
Varpa_4702	COG0765	amino acid transport
Varpa_4705	COG2207	Transcriptional regulator
Varpa_4706	COG2080	2 iron, 2 sulfur cluster binding
Varpa_4707	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Varpa_4708	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Varpa_4709	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Varpa_4710	COG0477	Major facilitator Superfamily
Varpa_4711	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Varpa_4712	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Varpa_4713	COG1845	cytochrome c oxidase, subunit III
Varpa_4714	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Varpa_4717	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Varpa_4720	COG0477	Major facilitator Superfamily
Varpa_4721	COG0583	DNA-binding transcription factor activity
Varpa_4725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Varpa_4727	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Varpa_4728	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Varpa_4729	COG3639	organic phosphonate transmembrane transporter activity
Varpa_4730	COG3639	organic phosphonate transmembrane transporter activity
Varpa_4731	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Varpa_4732	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Varpa_4734	COG0243	molybdopterin cofactor binding
Varpa_4737	COG0725	ABC transporter, periplasmic molybdate-binding protein
Varpa_4738	COG4149	molybdate abc transporter
Varpa_4742	COG0583	DNA-binding transcription factor activity
Varpa_4743	COG0489	protein tyrosine kinase activity
Varpa_4747	COG1473	amidohydrolase
Varpa_4748	COG1522	sequence-specific DNA binding
Varpa_4750	COG3132	Protein of unknown function, DUF480
Varpa_4751	COG3698	Phosphodiester glycosidase
Varpa_4752	COG0473	3-isopropylmalate dehydrogenase activity
Varpa_4753	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Varpa_4753	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Varpa_4755	COG0659	secondary active sulfate transmembrane transporter activity
Varpa_4759	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Varpa_4760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Varpa_4761	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Varpa_4762	COG0602	queuosine metabolic process
Varpa_4764	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Varpa_4766	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Varpa_4767	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Varpa_4769	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Varpa_4770	COG0588	phosphoglycerate mutase activity
Varpa_4771	COG0793	Belongs to the peptidase S41A family
Varpa_4772	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Varpa_4773	COG2982	Protein involved in outer membrane biogenesis
Varpa_4775	COG2197	response regulator
Varpa_4782	COG2823	Periplasmic or secreted lipoprotein
Varpa_4783	COG3237	CsbD-like
Varpa_4789	COG0494	nUDIX hydrolase
Varpa_4792	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Varpa_4795	COG4145	pantothenate transmembrane transporter activity
Varpa_4796	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Varpa_4799	COG2226	methyltransferase
Varpa_4804	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Varpa_4806	COG1175	transmembrane transport
Varpa_4807	COG0395	ABC-type sugar transport system, permease component
Varpa_4808	COG3842	ATPase activity
Varpa_4809	COG0584	glycerophosphoryl diester phosphodiesterase
Varpa_4810	COG1511	domain protein
Varpa_4810	COG3264	Mechanosensitive ion channel
Varpa_4811	COG1522	sequence-specific DNA binding
Varpa_4813	COG4120	Belongs to the binding-protein-dependent transport system permease family
Varpa_4814	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Varpa_4817	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Varpa_4818	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Varpa_4819	COG2890	protein-(glutamine-N5) methyltransferase activity
Varpa_4820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Varpa_4822	COG1253	flavin adenine dinucleotide binding
Varpa_4823	COG0741	lytic transglycosylase activity
Varpa_4824	COG0442	prolyl-tRNA aminoacylation
Varpa_4825	COG0494	nUDIX hydrolase
Varpa_4827	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Varpa_4828	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Varpa_4829	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Varpa_4830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Varpa_4831	COG0142	geranyltranstransferase activity
Varpa_4834	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Varpa_4836	COG1696	Membrane protein involved in D-alanine export
Varpa_4839	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Varpa_4840	COG2755	lipolytic protein G-D-S-L family
Varpa_4840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Varpa_4841	COG0494	nUDIX hydrolase
Varpa_4843	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Varpa_4844	COG0653	protein targeting
Varpa_4847	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Varpa_4850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Varpa_4851	COG0583	DNA-binding transcription factor activity
Varpa_4854	COG0784	Response regulator, receiver
Varpa_4854	COG2205	protein histidine kinase activity
Varpa_4854	COG5002	protein histidine kinase activity
Varpa_4855	COG0831	urea catabolic process
Varpa_4857	COG0832	Belongs to the urease beta subunit family
Varpa_4858	COG0804	urea catabolic process
Varpa_4861	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Varpa_4862	COG0830	nickel cation binding
Varpa_4863	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Varpa_4869	COG0745	RESPONSE REGULATOR receiver
Varpa_4873	COG2205	protein histidine kinase activity
Varpa_4874	COG0745	RESPONSE REGULATOR receiver
Varpa_4875	COG1289	transmembrane transporter activity
Varpa_4878	COG1959	2 iron, 2 sulfur cluster binding
Varpa_4880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Varpa_4883	COG0473	3-isopropylmalate dehydrogenase activity
Varpa_4884	COG0066	3-isopropylmalate dehydratase activity
Varpa_4885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Varpa_4887	COG0583	DNA-binding transcription factor activity
Varpa_4890	COG0583	DNA-binding transcription factor activity
Varpa_4892	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Varpa_4894	COG0024	Methionine aminopeptidase
Varpa_4900	COG1609	Transcriptional regulator
Varpa_4904	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_4906	COG0861	Integral membrane protein TerC family
Varpa_4919	COG1846	Transcriptional regulator
Varpa_4920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Varpa_4924	COG1960	acyl-CoA dehydrogenase activity
Varpa_4938	COG4977	sequence-specific DNA binding
Varpa_4949	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Varpa_4951	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_4952	COG0154	amidase activity
Varpa_4953	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Varpa_4955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Varpa_4956	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Varpa_4960	COG1561	YicC-like family, N-terminal region
Varpa_4961	COG0194	GDP metabolic process
Varpa_4962	COG1758	RNA polymerase activity
Varpa_4963	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Varpa_4966	COG0861	Integral membrane protein TerC family
Varpa_4969	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Varpa_4970	COG4792	protein secretion
Varpa_4971	COG1684	flagellar biosynthetic protein fliR
Varpa_4983	COG4789	Type iii secretion
Varpa_4985	COG4790	Type iii secretion
Varpa_4988	COG1420	regulation of RNA biosynthetic process
Varpa_4989	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Varpa_4990	COG0497	DNA recombination
Varpa_4991	COG1660	Displays ATPase and GTPase activities
Varpa_4993	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Varpa_4994	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Varpa_4997	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Varpa_4998	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Varpa_4999	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Varpa_5000	COG0193	aminoacyl-tRNA hydrolase activity
Varpa_5002	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Varpa_5004	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Varpa_5006	COG4608	Belongs to the ABC transporter superfamily
Varpa_5007	COG0747	negative chemotaxis
Varpa_5008	COG0747	negative chemotaxis
Varpa_5009	COG0154	amidase activity
Varpa_5011	COG0583	DNA-binding transcription factor activity
Varpa_5016	COG2267	carboxylic ester hydrolase activity
Varpa_5017	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Varpa_5019	COG1984	allophanate hydrolase subunit 2
Varpa_5020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Varpa_5021	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Varpa_5022	COG0742	ribosomal rna small subunit methyltransferase
Varpa_5025	COG0612	Peptidase, M16
Varpa_5026	COG0612	Peptidase, M16
Varpa_5028	COG2205	protein histidine kinase activity
Varpa_5028	COG0784	Response regulator, receiver
Varpa_5029	COG2197	response regulator
Varpa_5031	COG0747	negative chemotaxis
Varpa_5033	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Varpa_5037	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Varpa_5041	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Varpa_5042	COG4335	DNA alkylation repair
Varpa_5043	COG1999	signal sequence binding
Varpa_5044	COG0109	protoheme IX farnesyltransferase activity
Varpa_5051	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Varpa_5053	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Varpa_5056	COG2226	methyltransferase
Varpa_5058	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Varpa_5061	COG0489	protein tyrosine kinase activity
Varpa_5065	COG1024	Enoyl-CoA hydratase
Varpa_5069	COG1960	acyl-CoA dehydrogenase activity
Varpa_5072	COG2764	glyoxalase bleomycin resistance protein dioxygenase
Varpa_5075	COG5507	3-demethylubiquinone-9 3-methyltransferase
Varpa_5077	COG3485	protocatechuate 3,4-dioxygenase
Varpa_5079	COG1252	NADH dehydrogenase
Varpa_5090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Varpa_5095	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Varpa_5098	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_5102	COG0430	RNA-3'-phosphate cyclase activity
Varpa_5103	COG3541	Predicted nucleotidyltransferase
Varpa_5105	COG1690	Belongs to the RtcB family
Varpa_5107	COG4650	regulator
Varpa_5110	COG1073	alpha beta
Varpa_5115	COG0417	DNA replication proofreading
Varpa_5116	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Varpa_5119	COG3468	outer membrane autotransporter barrel domain protein
Varpa_5123	COG0784	Response regulator, receiver
Varpa_5123	COG5002	protein histidine kinase activity
Varpa_5123	COG2205	protein histidine kinase activity
Varpa_5128	COG2801	Transposase and inactivated derivatives
Varpa_5129	COG2963	transposase activity
Varpa_5138	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_5139	COG0183	Belongs to the thiolase family
Varpa_5140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Varpa_5142	COG1414	Transcriptional regulator
Varpa_5146	COG3063	Type IV pilus biogenesis stability protein PilW
Varpa_5151	COG4964	Belongs to the GSP D family
Varpa_5163	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Varpa_5166	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Varpa_5170	COG0583	DNA-binding transcription factor activity
Varpa_5171	COG3485	protocatechuate 3,4-dioxygenase
Varpa_5172	COG3485	protocatechuate 3,4-dioxygenase
Varpa_5174	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Varpa_5179	COG2911	Protein conserved in bacteria
Varpa_5182	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Varpa_5183	COG3383	formate dehydrogenase (NAD+) activity
Varpa_5186	COG0583	DNA-binding transcription factor activity
Varpa_5191	COG0469	pyruvate kinase activity
Varpa_5193	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Varpa_5194	COG0179	Fumarylacetoacetate (FAA) hydrolase
Varpa_5195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Varpa_5196	COG0045	succinate-CoA ligase (ADP-forming) activity
Varpa_5197	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Varpa_5198	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_5199	COG4191	Histidine kinase
Varpa_5213	COG1733	regulation of RNA biosynthetic process
Varpa_5218	COG0540	Belongs to the ATCase OTCase family
Varpa_5219	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Varpa_5220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Varpa_5221	COG1678	Uncharacterized ACR, COG1678
Varpa_5222	COG0415	Belongs to the DNA photolyase family
Varpa_5224	COG0840	transmembrane signaling receptor activity
Varpa_5228	COG1773	rubredoxin
Varpa_5230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Varpa_5232	COG0138	bifunctional purine biosynthesis protein purh
Varpa_5235	COG1238	metal cluster binding
Varpa_5237	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Varpa_5240	COG0012	GTP binding
Varpa_5241	COG1879	ABC-type sugar transport system periplasmic component
Varpa_5242	COG1129	ABC transporter
Varpa_5243	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_5244	COG1609	Transcriptional regulator
Varpa_5245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Varpa_5246	COG1869	D-ribose catabolic process
Varpa_5248	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_5249	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Varpa_5252	COG1024	Enoyl-CoA hydratase
Varpa_5259	COG1999	signal sequence binding
Varpa_5261	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_5263	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Varpa_5266	COG0183	Belongs to the thiolase family
Varpa_5268	COG2909	trisaccharide binding
Varpa_5271	COG1960	acyl-CoA dehydrogenase activity
Varpa_5272	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_5278	COG3501	Rhs element vgr protein
Varpa_5284	COG2255	four-way junction helicase activity
Varpa_5285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Varpa_5286	COG2267	carboxylic ester hydrolase activity
Varpa_5287	COG0671	phosphoesterase, PA-phosphatase related
Varpa_5287	COG2453	phosphatase
Varpa_5290	COG4589	Belongs to the CDS family
Varpa_5293	COG0632	four-way junction helicase activity
Varpa_5294	COG1702	phosphate starvation-inducible protein PhoH
Varpa_5295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Varpa_5296	COG1490	D-aminoacyl-tRNA deacylase activity
Varpa_5297	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Varpa_5302	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Varpa_5303	COG2814	Major facilitator Superfamily
Varpa_5304	COG0316	Belongs to the HesB IscA family
Varpa_5305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Varpa_5306	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Varpa_5308	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Varpa_5309	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Varpa_5311	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Varpa_5312	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Varpa_5317	COG3243	poly(R)-hydroxyalkanoic acid synthase
Varpa_5319	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Varpa_5322	COG4555	ABC transporter
Varpa_5326	COG3177	Filamentation induced by cAMP protein fic
Varpa_5329	COG2423	ornithine cyclodeaminase activity
Varpa_5330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Varpa_5334	COG0477	Major facilitator Superfamily
Varpa_5338	COG1280	lysine exporter protein (LysE YggA)
Varpa_5340	COG0583	DNA-binding transcription factor activity
Varpa_5341	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_5342	COG3485	protocatechuate 3,4-dioxygenase
Varpa_5345	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_5346	COG1254	Belongs to the acylphosphatase family
Varpa_5348	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_5351	COG1414	Transcriptional regulator
Varpa_5352	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Varpa_5357	COG1024	Enoyl-CoA hydratase
Varpa_5358	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Varpa_5359	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_5360	COG1960	acyl-CoA dehydrogenase activity
Varpa_5364	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Varpa_5365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Varpa_5366	COG3012	SEC-C Motif Domain Protein
Varpa_5367	COG0784	Response regulator, receiver
Varpa_5367	COG2205	protein histidine kinase activity
Varpa_5370	COG1408	metallophosphoesterase
Varpa_5371	COG1960	acyl-CoA dehydrogenase activity
Varpa_5373	COG0183	Belongs to the thiolase family
Varpa_5374	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Varpa_5375	COG0288	reversible hydration of carbon dioxide
Varpa_5376	COG0789	Transcriptional regulator
Varpa_5381	COG0129	dihydroxy-acid dehydratase activity
Varpa_5382	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Varpa_5383	COG2186	Transcriptional regulator
Varpa_5384	COG3842	ATPase activity
Varpa_5387	COG3833	ABC-type maltose transport systems, permease component
Varpa_5390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Varpa_5393	COG0751	glycine-tRNA ligase activity
Varpa_5394	COG0752	glycyl-tRNA synthetase alpha subunit
Varpa_5395	COG1597	lipid kinase activity
Varpa_5401	COG2814	Major facilitator Superfamily
Varpa_5402	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Varpa_5403	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_5404	COG3246	L-lysine catabolic process to acetate
Varpa_5408	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_5410	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_5417	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_5419	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Varpa_5420	COG4535	Mg2 and Co2 transporter CorC
Varpa_5422	COG1522	sequence-specific DNA binding
Varpa_5425	COG3186	Phenylalanine-4-hydroxylase
Varpa_5426	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_5429	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Varpa_5435	COG2095	MarC family integral membrane protein
Varpa_5439	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_5441	COG0501	Belongs to the peptidase M48B family
Varpa_5455	COG0439	Biotin carboxylase
Varpa_5456	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_5460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Varpa_5460	COG2124	cytochrome p450
Varpa_5462	COG1309	transcriptional regulator
Varpa_5466	COG1505	serine-type exopeptidase activity
Varpa_5467	COG0010	Belongs to the arginase family
Varpa_5469	COG1072	(Pantothenic acid kinase))
Varpa_5470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Varpa_5476	COG2084	Dehydrogenase
Varpa_5478	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Varpa_5479	COG0792	nuclease activity
Varpa_5480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Varpa_5483	COG1309	transcriptional regulator
Varpa_5484	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Varpa_5486	COG1538	Outer membrane efflux protein
Varpa_5496	COG3118	belongs to the thioredoxin family
Varpa_5497	COG1201	RNA secondary structure unwinding
Varpa_5498	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Varpa_5498	COG1793	dna ligase
Varpa_5499	COG1793	dna ligase
Varpa_5499	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Varpa_5503	COG1879	ABC-type sugar transport system periplasmic component
Varpa_5504	COG1172	Belongs to the binding-protein-dependent transport system permease family
Varpa_5507	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Varpa_5508	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Varpa_5509	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Varpa_5510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Varpa_5511	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Varpa_5512	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Varpa_5514	COG0356	it plays a direct role in the translocation of protons across the membrane
Varpa_5516	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Varpa_5517	COG2921	Belongs to the UPF0250 family
Varpa_5518	COG0321	lipoyl(octanoyl) transferase activity
Varpa_5519	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Varpa_5523	COG3501	Rhs element vgr protein
Varpa_5554	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_5559	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Varpa_5566	COG3121	Chaperone
Varpa_5568	COG2130	NADP-dependent
Varpa_5570	COG0745	RESPONSE REGULATOR receiver
Varpa_5574	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Varpa_5575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Varpa_5579	COG3909	cytochrome
Varpa_5582	COG0678	peroxiredoxin activity
Varpa_5583	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Varpa_5584	COG0255	Belongs to the universal ribosomal protein uL29 family
Varpa_5585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Varpa_5586	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Varpa_5587	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Varpa_5588	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Varpa_5589	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Varpa_5590	COG0089	rRNA binding
Varpa_5591	COG0088	Forms part of the polypeptide exit tunnel
Varpa_5592	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Varpa_5595	COG0051	transcription antitermination factor activity, RNA binding
Varpa_5596	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Varpa_5597	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Varpa_5598	COG0049	tRNA binding
Varpa_5599	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Varpa_5600	COG1686	Belongs to the peptidase S11 family
Varpa_5601	COG2945	thiolester hydrolase activity
Varpa_5606	COG0598	Magnesium transport protein CorA
Varpa_5609	COG0583	DNA-binding transcription factor activity
Varpa_5610	COG0412	Dienelactone hydrolase
Varpa_5612	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_5613	COG2095	MarC family integral membrane protein
Varpa_5617	COG0410	ABC transporter
Varpa_5618	COG0411	ABC transporter
Varpa_5620	COG0559	Belongs to the binding-protein-dependent transport system permease family
Varpa_5623	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Varpa_5624	COG1250	3-hydroxyacyl-CoA dehydrogenase
Varpa_5627	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Varpa_5628	COG1652	LysM domain
Varpa_5632	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Varpa_5635	COG0574	Belongs to the PEP-utilizing enzyme family
Varpa_5635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Varpa_5637	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Varpa_5638	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Varpa_5640	COG0640	Transcriptional regulator
Varpa_5641	COG2124	cytochrome p450
Varpa_5643	COG0625	glutathione transferase activity
Varpa_5644	COG0583	DNA-binding transcription factor activity
Varpa_5647	COG1131	(ABC) transporter
Varpa_5649	COG1846	Transcriptional regulator
Varpa_5650	COG1764	response to oxidative stress
Varpa_5652	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Varpa_5653	COG0583	DNA-binding transcription factor activity
Varpa_5654	COG1960	acyl-CoA dehydrogenase activity
Varpa_5655	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_5656	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Varpa_5663	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Varpa_5664	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Varpa_5665	COG0714	Associated with various cellular activities
Varpa_5669	COG0326	Molecular chaperone. Has ATPase activity
Varpa_5671	COG1840	ABC-type Fe3 transport system, periplasmic component
Varpa_5672	COG0583	DNA-binding transcription factor activity
Varpa_5674	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Varpa_5676	COG0642	Histidine kinase
Varpa_5677	COG0745	RESPONSE REGULATOR receiver
Varpa_5679	COG1187	pseudouridine synthase activity
Varpa_5680	COG1051	belongs to the nudix hydrolase family
Varpa_5680	COG1056	cytidyltransferase-related domain
Varpa_5682	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Varpa_5686	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Varpa_5689	COG0745	RESPONSE REGULATOR receiver
Varpa_5690	COG2205	protein histidine kinase activity
Varpa_5693	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Varpa_5694	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Varpa_5695	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Varpa_5698	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Varpa_5701	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Varpa_5704	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Varpa_5706	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_5708	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Varpa_5709	COG1022	Amp-dependent synthetase and ligase
Varpa_5710	COG0411	ABC transporter
Varpa_5716	COG0318	PFAM AMP-dependent synthetase and ligase
Varpa_5717	COG3501	Rhs element vgr protein
Varpa_5723	COG0372	Belongs to the citrate synthase family
Varpa_5724	COG0372	Belongs to the citrate synthase family
Varpa_5725	COG0693	protein deglycase activity
Varpa_5731	COG3501	Rhs element vgr protein
Varpa_5732	COG3209	COG3209 Rhs family protein
Varpa_5736	COG1940	carbohydrate kinase activity
Varpa_5738	COG4214	carbohydrate transport
Varpa_5739	COG4213	ABC transporter substrate-binding protein
Varpa_5741	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Varpa_5742	COG0022	dehydrogenase e1 component
Varpa_5743	COG1028	Short-chain dehydrogenase reductase Sdr
Varpa_5744	COG0583	DNA-binding transcription factor activity
Varpa_5747	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Varpa_5750	COG1024	Enoyl-CoA hydratase
Varpa_5751	COG1960	acyl-CoA dehydrogenase activity
Varpa_5754	COG4977	sequence-specific DNA binding
Varpa_5756	COG0203	ribosomal protein L17
Varpa_5757	COG0202	RNA polymerase activity
Varpa_5758	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Varpa_5759	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Varpa_5760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Varpa_5761	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Varpa_5762	COG0201	protein transport
Varpa_5763	COG0200	Binds to the 23S rRNA
Varpa_5764	COG1841	ribosomal large subunit assembly
Varpa_5765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Varpa_5766	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Varpa_5767	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Varpa_5768	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Varpa_5769	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Varpa_5770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Varpa_5771	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Varpa_5772	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Varpa_5776	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Varpa_5777	COG0783	Belongs to the Dps family
Varpa_5780	COG0038	chloride channel
Varpa_5781	COG5295	Hep Hag repeat protein
Varpa_5785	COG1280	lysine exporter protein (LysE YggA)
Varpa_5786	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Varpa_5787	COG1090	epimerase
Varpa_5789	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Varpa_5790	COG0343	queuine tRNA-ribosyltransferase activity
Varpa_5801	COG0284	orotidine-5'-phosphate decarboxylase activity
Varpa_5804	COG1214	PFAM Peptidase M22, glycoprotease
Varpa_5805	COG1349	DNA-binding transcription factor activity
Varpa_5806	COG0494	nUDIX hydrolase
Varpa_5807	COG2027	D-alanyl-D-alanine carboxypeptidase
Varpa_5809	COG0009	L-threonylcarbamoyladenylate synthase
Varpa_5810	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Varpa_5811	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Varpa_5813	COG3620	sequence-specific DNA binding
Varpa_5814	COG3550	peptidyl-serine autophosphorylation
Varpa_5816	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Varpa_5819	COG1522	sequence-specific DNA binding
Varpa_5820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Varpa_5821	COG0469	pyruvate kinase activity
Varpa_5822	COG0126	phosphoglycerate kinase activity
Varpa_5826	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Varpa_5832	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Varpa_5834	COG0242	peptide deformylase activity
Varpa_5836	COG0758	DNA mediated transformation
Varpa_5837	COG2922	Belongs to the Smg family
Varpa_5839	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Varpa_5840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Varpa_5843	COG1522	sequence-specific DNA binding
Varpa_5849	COG0765	amino acid transport
Varpa_5850	COG2814	Major facilitator Superfamily
Varpa_5853	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Varpa_5859	COG0251	oxidation-reduction process
Varpa_5861	COG3622	Belongs to the hyi family
Varpa_5862	COG0235	Class ii aldolase
Varpa_5863	COG3395	kinase activity
Varpa_5864	COG2084	Dehydrogenase
Varpa_5866	COG1522	sequence-specific DNA binding
Varpa_5872	COG4566	intracellular signal transduction
Varpa_5874	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Varpa_5876	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Varpa_5877	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Varpa_5878	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Varpa_5879	COG1595	DNA-templated transcription, initiation
Varpa_5884	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Varpa_5887	COG0625	glutathione transferase activity
Varpa_5890	COG4772	TonB-dependent receptor
Varpa_5891	COG4681	YaeQ
Varpa_5894	COG0861	Integral membrane protein TerC family
Varpa_5896	COG1950	PFAM Membrane protein of
Varpa_5897	COG4783	chaperone-mediated protein folding
Varpa_5898	COG0315	cyclic pyranopterin monophosphate synthase activity
Varpa_5908	COG4969	Belongs to the N-Me-Phe pilin family
Varpa_5909	COG1234	tRNA 3'-trailer cleavage
Varpa_5911	COG1716	ATPase activity
Varpa_5912	COG0631	protein serine/threonine phosphatase activity
Varpa_5913	COG0861	Integral membrane protein TerC family
Varpa_5914	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Varpa_5915	COG0045	succinate-CoA ligase (ADP-forming) activity
Varpa_5916	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Varpa_5918	COG4682	membrane
Varpa_5920	COG2137	regulation of response to DNA damage stimulus
Varpa_5921	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Varpa_5925	COG0642	Histidine kinase
Varpa_5928	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Varpa_5928	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Varpa_5932	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Varpa_5936	COG2814	Major facilitator Superfamily
Varpa_5938	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Varpa_5939	COG0513	Belongs to the DEAD box helicase family
Varpa_5943	COG0697	spore germination
Varpa_5945	COG1802	Transcriptional regulator
Varpa_5951	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Varpa_5952	COG3550	peptidyl-serine autophosphorylation
Varpa_5955	COG1473	amidohydrolase
Varpa_5959	COG1047	Peptidyl-prolyl cis-trans
Varpa_5964	COG3181	Tripartite tricarboxylate transporter family receptor
Varpa_5966	COG0583	DNA-binding transcription factor activity
Varpa_5969	COG1914	H( )-stimulated, divalent metal cation uptake system
Varpa_5970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Varpa_5973	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Varpa_5974	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Varpa_5975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Varpa_5976	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Varpa_5977	COG0006	proline dipeptidase activity
Varpa_5981	COG4953	penicillin-binding protein 1C
Varpa_5982	COG2373	Large extracellular alpha-helical protein
Varpa_5987	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Varpa_5991	COG0280	phosphate acetyltransferase
Varpa_5991	COG0281	malic enzyme
Varpa_5994	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Varpa_5995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Varpa_5996	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Varpa_5998	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Varpa_6001	COG2814	Major facilitator Superfamily
Varpa_6002	COG2267	carboxylic ester hydrolase activity
Varpa_6006	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Varpa_6007	COG1739	Uncharacterized protein family UPF0029
Varpa_6008	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Varpa_6008	COG2813	Specifically methylates the guanine in position
Varpa_6009	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Varpa_6010	COG2119	membrane
Varpa_6011	COG0724	RNA recognition motif
Varpa_6012	COG4221	oxidoreductase activity
Varpa_6014	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Varpa_6018	COG2066	Belongs to the glutaminase family
Varpa_6018	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Varpa_6019	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Varpa_6020	COG0706	membrane insertase activity
Varpa_6021	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Varpa_6022	COG0594	ribonuclease P activity
Varpa_6023	COG0230	Belongs to the bacterial ribosomal protein bL34 family