locus-tag class description Vapar_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Vapar_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Vapar_0003 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Vapar_0008 ENOG4107RN3 metallophosphoesterase Vapar_0010 ENOG41061N2 exported protein Vapar_0011 ENOG4107UXM Membrane Vapar_0012 ENOG4105DZQ phospholipase D Transphosphatidylase Vapar_0013 ENOG4105X23 Endonuclease Exonuclease phosphatase Vapar_0017 ENOG4105EUB pirin domain protein Vapar_0019 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Vapar_0023 ENOG4105CT7 inner membrane cred family protein Vapar_0024 ENOG4108JQC penicillin-binding protein 1A Vapar_0026 ENOG4105EB3 Histidine kinase Vapar_0027 ENOG4105E3W Two component transcriptional regulator (Winged helix family Vapar_0030 ENOG410681U heavy metal transport detoxification protein Vapar_0031 ENOG4105C59 p-type ATPase Vapar_0032 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Vapar_0033 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Vapar_0036 ENOG4105XJC Two component transcriptional regulator (Winged helix family Vapar_0037 ENOG4105ECM Sensor protein basS pmrB Vapar_0039 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Vapar_0042 ENOG4108K3A Glutathione S-transferase Vapar_0045 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Vapar_0046 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Vapar_0047 ENOG4108NIW Leucine export protein LeuE Vapar_0048 ENOG4107QJE Chromosome Partitioning Protein Vapar_0052 ENOG4105CQB FAD linked oxidase domain protein Vapar_0054 ENOG4108WBT adenosyltransferase Vapar_0061 ENOG4107R11 Transcriptional regulator Vapar_0065 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Vapar_0066 ENOG4107QMS site-determining protein Vapar_0067 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Vapar_0068 ENOG4105C2W permease Vapar_0069 ENOG4105KA0 thioesterase Superfamily protein Vapar_0072 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) Vapar_0074 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme Vapar_0077 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Vapar_0078 ENOG4105VSH 4-oxalocrotonate tautomerase Vapar_0079 ENOG4105CHR reductase Vapar_0080 ENOG4105EXG Transcriptional regulator Vapar_0083 ENOG4108IV0 ABC, transporter Vapar_0084 ENOG4105C0Z ABC transporter Vapar_0086 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_0092 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Vapar_0099 ENOG4105C3M thioredoxin reductase Vapar_0101 ENOG4107XCH Cyclase family Vapar_0102 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component Vapar_0103 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_0104 ENOG4105D7T ABC transporter Vapar_0107 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Vapar_0108 ENOG4108T5G Adenylate Vapar_0111 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_0112 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_0114 ENOG4108ERU trap dicarboxylate transporter subunit DctP Vapar_0115 ENOG41069M3 Transcriptional regulator Vapar_0116 ENOG41082T9 Membrane Vapar_0117 ENOG4105ETT transcriptional Regulator, LysR family Vapar_0118 ENOG4105C1G acyl-Coa dehydrogenase Vapar_0119 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_0121 ENOG4105RRV Inherit from COG: copper resistance Vapar_0123 ENOG4108RG0 uracil-dna glycosylase Vapar_0128 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme Vapar_0129 ENOG4105CHR reductase Vapar_0134 ENOG4105DUM transcriptional regulator, lysR family Vapar_0135 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) Vapar_0137 ENOG4105CSV Glutaminase Vapar_0142 ENOG4107RZC phospholipase d Vapar_0147 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Vapar_0149 ENOG4105C7B Threonine dehydratase Vapar_0153 ENOG4105C9U ATP-dependent DNA helicase RecQ Vapar_0155 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_0157 ENOG4105CZE histidine utilization repressor Vapar_0158 ENOG4105C84 Histidine ammonia-lyase Vapar_0159 ENOG4105CGP Urocanate hydratase Vapar_0161 ENOG4105EAB amino acid AbC transporter Vapar_0162 ENOG4105E5Q amino acid AbC transporter Vapar_0163 ENOG41090B9 response to stress Vapar_0164 ENOG4105CI2 imidazolone-5-propionate hydrolase Vapar_0165 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Vapar_0167 ENOG4105C3R Methionine synthase Vapar_0171 ENOG4105C3R Methionine synthase Vapar_0172 ENOG41063ZV Vapar_0173 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 Vapar_0176 ENOG4108W9H Tetr family transcriptional regulator Vapar_0177 ENOG4105DP0 ferredoxin-NADP reductase Vapar_0183 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_0185 ENOG4105C0Z ABC transporter Vapar_0186 ENOG4108IV0 ABC, transporter Vapar_0187 ENOG4108RWI nicotinamidase Vapar_0189 ENOG4108XHQ (2Fe-2S)-binding domain protein Vapar_0190 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Vapar_0200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Vapar_0201 ENOG4105CS6 Rhs element vgr protein Vapar_0212 ENOG4106VK6 Flagellar motor protein Vapar_0215 ENOG4107QPV Serine Threonine protein kinase Vapar_0216 ENOG4105C0P Mg chelatase subunit ChlI Vapar_0218 ENOG4108YZA Nitrogen regulatory protein pii Vapar_0219 ENOG4105BZU Histidine kinase Vapar_0222 ENOG4105CQB FAD linked oxidase domain protein Vapar_0223 ENOG4105EU8 FAD linked oxidase domain protein Vapar_0224 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Vapar_0226 ENOG4108V06 Glutathione peroxidase Vapar_0228 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) Vapar_0229 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Vapar_0231 ENOG4105EXG Transcriptional regulator Vapar_0234 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Vapar_0235 ENOG4105MP9 class II Aldolase Vapar_0236 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_0237 ENOG4105C01 Dihydroxy-acid dehydratase Vapar_0242 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase Vapar_0243 ENOG4105C26 Dehydrogenase Vapar_0246 ENOG4108V8F Transcriptional regulator, MarR family Vapar_0248 ENOG4105CNA YD repeat protein Vapar_0248 ENOG4105CNA YD repeat protein Vapar_0250 ENOG4105CS6 Rhs element vgr protein Vapar_0251 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Vapar_0253 ENOG4105DH7 May be involved in recombination (By similarity) Vapar_0254 ENOG4105CM2 brancheD-chain amino acid aminotransferase Vapar_0258 ENOG4105E0F Histidine kinase Vapar_0260 ENOG4105D5U fad dependent oxidoreductase Vapar_0263 ENOG4105EYM Major Facilitator superfamily Vapar_0267 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_0273 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Vapar_0274 ENOG4108JQ9 ABC transporter Vapar_0277 ENOG4105CGK Exodeoxyribonuclease III Vapar_0278 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Vapar_0280 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Vapar_0281 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_0282 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Vapar_0283 ENOG4105DFF Rod shape-determining protein mreb Vapar_0286 ENOG4105CJN penicillin-binding protein Vapar_0289 ENOG4105F1J Homogentisate 1,2-dioxygenase Vapar_0294 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Vapar_0298 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Vapar_0300 ENOG4105CN8 Transcriptional regulator Vapar_0303 ENOG41080HI glycine oxidase Vapar_0306 ENOG4105D38 putrescine abc transporter Vapar_0307 ENOG4105F38 ABC transporter, permease Vapar_0308 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_0312 ENOG4105CHM Aminotransferase Vapar_0319 ENOG4105VFU Rna-binding protein Vapar_0321 ENOG4108ZJT translation initiation factor, Sui1 Vapar_0322 ENOG4105C1J atp-dependent rna helicase Vapar_0323 ENOG4107QX8 SPFH domain, Band 7 family protein Vapar_0324 ENOG4105C1G acyl-Coa dehydrogenase Vapar_0326 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Vapar_0327 ENOG4107QX3 carboxylase Vapar_0328 ENOG4105BZU Histidine kinase Vapar_0330 ENOG4106BRA Membrane Vapar_0331 ENOG4105CWC Acetylornithine deacetylase Vapar_0332 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Vapar_0333 ENOG4105CH2 amidohydrolase Vapar_0336 ENOG4108J2R molybdopterin oxidoreductase Vapar_0339 ENOG4108R85 Short chain dehydrogenase Vapar_0340 ENOG4105CMG Carbohydrate kinase Vapar_0341 ENOG4105CPQ Dehydrogenase Vapar_0342 ENOG4105CNN ABC, transporter Vapar_0344 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Vapar_0345 ENOG4108W3Q Transcriptional regulator Vapar_0346 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_0355 ENOG4105MSY salicylate hydroxylase Vapar_0359 ENOG4105C29 acyl-CoA thioesterase Vapar_0360 ENOG4105CHR reductase Vapar_0362 ENOG4108IV0 ABC, transporter Vapar_0363 ENOG4105C0Z ABC transporter Vapar_0364 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Vapar_0365 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_0367 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Vapar_0369 ENOG41061GT Aldolase Vapar_0370 ENOG4108FN7 Aldo keto reductase Vapar_0371 ENOG4105CNN ABC, transporter Vapar_0374 ENOG4105CMG Carbohydrate kinase Vapar_0376 ENOG4105FDP GntR family transcriptional regulator Vapar_0379 ENOG4108UUM single-stranded DNA-binding protein Vapar_0382 ENOG4105CDY transcriptional regulatory protein Vapar_0386 ENOG4105DEN Luciferase family Vapar_0387 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Vapar_0391 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Vapar_0392 ENOG4105W8H transhydrogenase (subunit alpha Vapar_0393 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Vapar_0394 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_0395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Vapar_0396 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_0397 ENOG4105C3U ABC transporter Vapar_0398 ENOG4108JQ7 (ABC) transporter Vapar_0399 ENOG4105DEF Extracellular solute-binding protein, family 5 Vapar_0400 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Vapar_0401 ENOG4107QUT magnesium and cobalt transport protein CorA Vapar_0403 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA Vapar_0404 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Vapar_0405 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Vapar_0406 ENOG41090R7 Ferric uptake Vapar_0407 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Vapar_0410 ENOG4105SG9 biopolymer transport protein, ExbD Vapar_0411 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Vapar_0412 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Vapar_0413 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Vapar_0414 ENOG4108IUM Glycogen debranching enzyme Vapar_0415 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Vapar_0416 ENOG4105CG3 alpha amylase, catalytic region Vapar_0417 ENOG4105E1J oxidoreductase Vapar_0422 ENOG4105C8T Leucyl-tRNA synthetase Vapar_0425 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Vapar_0427 ENOG4105DFH Transport of potassium into the cell (By similarity) Vapar_0431 ENOG4105DKK Benzoate Vapar_0432 ENOG4105D7Z glutathione synthase Vapar_0435 ENOG4105E7A Glutamine amidotransferase Vapar_0437 ENOG4105C0R drug resistance transporter emrb qaca subfamily Vapar_0440 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 Vapar_0444 ENOG4108UKI Enoyl-CoA hydratase Vapar_0445 ENOG4105F2C Acetyl-CoA acetyltransferase Vapar_0447 ENOG4105ETT transcriptional Regulator, LysR family Vapar_0451 ENOG4105DFS Conserved Protein Vapar_0452 ENOG4107QP3 malate synthase g Vapar_0454 ENOG4107258 Transcriptional regulator Vapar_0455 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Vapar_0456 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_0461 ENOG4105C75 arginyL-tRNA synthetase Vapar_0463 ENOG4108Z33 Thiol disulfide Interchange Protein Vapar_0464 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA Vapar_0465 ENOG4108IUZ ABC transporter Vapar_0466 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Vapar_0467 ENOG4107RZC phospholipase d Vapar_0473 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Vapar_0478 ENOG4105CBC glutamate synthase Vapar_0479 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Vapar_0484 ENOG4108ZAI phosphatidylglycerophosphatase a Vapar_0487 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Vapar_0488 ENOG4108W2Y isochorismatase Vapar_0489 ENOG4105ECQ AraC Family Transcriptional Regulator Vapar_0490 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) Vapar_0493 ENOG4105NWN ApaG protein Vapar_0494 ENOG4105DJV ribulose-phosphate 3-epimerase Vapar_0497 ENOG4105FDF Could be involved in DNA repair (By similarity) Vapar_0498 ENOG4105DQE DNA ligase Vapar_0508 ENOG4108YBA Histidine kinase Vapar_0510 ENOG4105BZU Histidine kinase Vapar_0512 ENOG4105EHI Phosphonate ABC transporter, periplasmic Vapar_0513 ENOG4105EHI Phosphonate ABC transporter, periplasmic Vapar_0515 ENOG4106VK6 Flagellar motor protein Vapar_0519 ENOG4105D9P serine threonine protein kinase Vapar_0530 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Vapar_0531 ENOG4105CS6 Rhs element vgr protein Vapar_0536 ENOG4105CS6 Rhs element vgr protein Vapar_0548 ENOG4108WC9 type VI secretion system effector, hcp1 family Vapar_0556 ENOG4105H3G oxidoreductase Vapar_0563 ENOG4107SQD Transcriptional regulator, GntR family Vapar_0571 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Vapar_0575 ENOG4105DDQ anthranilate synthase Vapar_0578 ENOG4107QYG anthranilate phosphoribosyltransferase Vapar_0579 ENOG4105DK0 Indole-3-glycerol phosphate synthase Vapar_0580 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Vapar_0581 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Vapar_0584 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Vapar_0585 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Vapar_0586 ENOG4108VZM 50s ribosomal protein L10 Vapar_0587 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Vapar_0588 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Vapar_0589 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Vapar_0591 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Vapar_0593 ENOG4105ES5 Histidine kinase Vapar_0610 ENOG4108Z9W Outer membrane porin Vapar_0612 ENOG4105EBR Carboxylesterase Vapar_0616 ENOG4105ERH Fumarylacetoacetate hydrolase Vapar_0617 ENOG4105KME endoribonuclease L-psp Vapar_0618 ENOG4105DG4 malate L-lactate dehydrogenase Vapar_0620 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component Vapar_0622 ENOG4107XKF NMT1 THI5 Like Domain Protein Vapar_0623 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase Vapar_0624 ENOG4105CHR reductase Vapar_0627 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Vapar_0629 ENOG4108K3Z AraC family transcriptional regulator Vapar_0632 ENOG4108IV0 ABC, transporter Vapar_0633 ENOG4105C0Z ABC transporter Vapar_0635 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_0636 ENOG4105FUY alpha subunit Vapar_0637 ENOG4108SBK dioxygenase, subunit beta Vapar_0638 ENOG4105D3W isochorismatase Vapar_0647 ENOG4106IPI cyclase, family Vapar_0654 ENOG4105ERH Fumarylacetoacetate hydrolase Vapar_0660 ENOG4105EXG Transcriptional regulator Vapar_0662 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Vapar_0664 ENOG4108YXQ IS66 Orf2 family protein Vapar_0665 ENOG4105E5H Transposase Vapar_0678 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_0686 ENOG41067CV Integrase Vapar_0687 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_0691 ENOG4105D64 Mechanosensitive ion channel Vapar_0696 ENOG4105BZ9 Cytochrome C oxidase, subunit I Vapar_0697 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Vapar_0699 ENOG4108Q1J Extracellular solute-binding protein, family 3 Vapar_0700 ENOG4105DZG Dehydrogenase Vapar_0702 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Vapar_0709 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_0711 ENOG4105DUM transcriptional regulator, lysR family Vapar_0712 ENOG4105K70 DNA-binding protein Vapar_0713 ENOG4105F04 LysR family Transcriptional regulator Vapar_0715 ENOG4105BZU Histidine kinase Vapar_0716 ENOG4105BZU Histidine kinase Vapar_0717 ENOG4105BZU Histidine kinase Vapar_0718 ENOG4107RA1 nh(3)-dependent nad( ) synthetase Vapar_0719 ENOG4105HDD phospholipase Vapar_0721 ENOG4105C4R Atp-dependent dna helicase Vapar_0722 ENOG4105RK9 auxin efflux carrier Vapar_0726 ENOG4105C25 Primosomal protein n' Vapar_0727 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Vapar_0729 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Vapar_0735 ENOG4105CBN LysR family transcriptional regulator Vapar_0736 ENOG4105DTD Dehydrogenase Vapar_0739 ENOG410829K Lysine exporter protein (Lyse ygga) Vapar_0741 ENOG4105JAB phenazine biosynthesis protein, phzf family Vapar_0742 ENOG4108TGY Glutathione S-transferase Vapar_0743 ENOG4108NIW Leucine export protein LeuE Vapar_0745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Vapar_0746 ENOG4105T38 integral membrane protein Vapar_0751 ENOG4105MWK D-amino acid dehydrogenase, small subunit Vapar_0753 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Vapar_0755 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Vapar_0756 ENOG4108DMA Nad-dependent epimerase dehydratase Vapar_0757 ENOG4105C0K Gdp-mannose 4,6-dehydratase Vapar_0758 ENOG4105E2K Glycosyl transferase (Group 1 Vapar_0761 ENOG4105E2K Glycosyl transferase (Group 1 Vapar_0766 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Vapar_0770 ENOG4105EXC Acyl-transferase Vapar_0773 ENOG4105CAS nag kinase Vapar_0777 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Vapar_0778 ENOG4105CH6 catalase Vapar_0782 ENOG4105DG4 malate L-lactate dehydrogenase Vapar_0783 ENOG4105CTX dehydratase Vapar_0784 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_0786 ENOG4108ERU trap dicarboxylate transporter subunit DctP Vapar_0787 ENOG4107YCY Transcriptional regulator Vapar_0788 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Vapar_0789 ENOG4106517 Short-chain dehydrogenase reductase Sdr Vapar_0790 ENOG4105ERH Fumarylacetoacetate hydrolase Vapar_0791 ENOG4105FDP GntR family transcriptional regulator Vapar_0792 ENOG4105CP9 extracellular ligand-binding receptor Vapar_0793 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_0794 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Vapar_0795 ENOG4105C0Z ABC transporter Vapar_0796 ENOG4108IV0 ABC, transporter Vapar_0798 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Vapar_0799 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Vapar_0807 ENOG4105EJC lysr family transcriptional regulator Vapar_0808 ENOG4107GJV short-chain dehydrogenase reductase Vapar_0810 ENOG4105CSU acyl-Coa dehydrogenase Vapar_0813 ENOG4105WDY DNA (cytosine-5-)-methyltransferase Vapar_0814 ENOG4105CHU acetyl-coa acetyltransferase Vapar_0817 ENOG4105CHR reductase Vapar_0820 ENOG41060WC Enoyl-CoA hydratase Vapar_0821 ENOG4105CAD extracellular ligand-binding receptor Vapar_0822 ENOG4105NAU thioesterase Superfamily protein Vapar_0823 ENOG4108JJ7 ABC transporter Vapar_0824 ENOG4105C5I Dehydrogenase Vapar_0825 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_0826 ENOG4107YNJ LysR family Transcriptional regulator Vapar_0827 ENOG4108IJ0 Aspartate ammonia-lyase Vapar_0828 ENOG4107RP9 extracellular solute-binding protein, family 3 Vapar_0829 ENOG4105EAD ABC transporter Vapar_0830 ENOG4105DRP amino acid AbC transporter Vapar_0831 ENOG4105CDA abc transporter atp-binding protein Vapar_0833 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_0834 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_0835 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ Vapar_0837 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_0839 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_0840 ENOG4105E39 Enoyl-CoA hydratase Vapar_0841 ENOG4105C1G acyl-Coa dehydrogenase Vapar_0842 ENOG4105CC9 acyl-Coa dehydrogenase Vapar_0843 ENOG4105CHU acetyl-coa acetyltransferase Vapar_0844 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Vapar_0845 ENOG4105CBN LysR family transcriptional regulator Vapar_0848 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_0850 ENOG4108JQ7 (ABC) transporter Vapar_0851 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_0853 ENOG4105DEF Extracellular solute-binding protein, family 5 Vapar_0854 ENOG4105EKE dihydroorotase Vapar_0859 ENOG4105D0M Protease HtpX homolog Vapar_0862 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) Vapar_0863 ENOG4105EW6 flavin reductase domain protein, FMN-binding Vapar_0864 ENOG4105DZ0 fad dependent oxidoreductase Vapar_0868 ENOG4105ZQC membrane protein AaeX Vapar_0869 ENOG4105Y49 secretion protein, HlyD family Vapar_0871 ENOG4105C2C drug resistance transporter, Bcr CflA Vapar_0873 ENOG4105FE9 pseudouridine synthase Vapar_0874 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Vapar_0881 ENOG4105HSS phospholipase C Vapar_0886 ENOG4105FTV AraC Family Transcriptional Regulator Vapar_0894 ENOG4105CS6 Rhs element vgr protein Vapar_0899 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Vapar_0902 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Vapar_0903 ENOG4105DR4 Methyltransferase Vapar_0904 ENOG4105CKI cobalamin synthesis protein Vapar_0906 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Vapar_0908 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Vapar_0909 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Vapar_0910 ENOG4108V6E Cell division protein mraZ Vapar_0911 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Vapar_0912 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Vapar_0913 ENOG4105CJN penicillin-binding protein Vapar_0914 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Vapar_0915 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Vapar_0916 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Vapar_0917 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Vapar_0918 ENOG4105CNI cell division protein FtsW Vapar_0919 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Vapar_0920 ENOG4105DFU Cell wall formation (By similarity) Vapar_0921 ENOG4105CPF Cell wall formation (By similarity) Vapar_0922 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) Vapar_0923 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Vapar_0924 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Vapar_0925 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Vapar_0928 ENOG4105ETT transcriptional Regulator, LysR family Vapar_0929 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Vapar_0930 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Vapar_0931 ENOG4105KNE Phosphatidate cytidylyltransferase Vapar_0935 ENOG4105E2X shikimate dehydrogenase Vapar_0938 ENOG4105IPS esterase Vapar_0939 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_0941 ENOG4105CNI cell division protein FtsW Vapar_0942 ENOG4105D1U peptidase U62 modulator of DNA gyrase Vapar_0944 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Vapar_0946 ENOG4105DFU Cell wall formation (By similarity) Vapar_0948 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Vapar_0949 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Vapar_0950 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Vapar_0951 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Vapar_0955 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Vapar_0956 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Vapar_0958 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Vapar_0959 ENOG4107TUY Histidine kinase Vapar_0962 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Vapar_0963 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) Vapar_0965 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Vapar_0967 ENOG4107WP9 Histidine kinase Vapar_0968 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Vapar_0971 ENOG4105BZS acriflavin resistance protein Vapar_0974 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Vapar_0978 ENOG4105E2B Taurine dioxygenase Vapar_0979 ENOG4105M0Y Vapar_0983 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Vapar_0986 ENOG4105BZP glycoside hydrolase 15-related Vapar_0987 ENOG4108K4C ec 3.1.3.12 Vapar_0988 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Vapar_0990 ENOG4107MKT Stringent starvation protein a Vapar_0991 ENOG4108302 MgtC SapB transporter Vapar_0992 ENOG4107SC1 transglycosylase Vapar_0993 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Vapar_0994 ENOG4105ETT transcriptional Regulator, LysR family Vapar_0997 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Vapar_0999 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Vapar_1000 ENOG4105EW9 transcriptional regulator AsnC family Vapar_1001 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Vapar_1003 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Vapar_1010 ENOG4107R0V Pyruvate dehydrogenase Vapar_1011 ENOG4105CPP Dehydrogenase, E1 component Vapar_1012 ENOG4107QSN dihydrolipoamide acetyltransferase Vapar_1013 ENOG4105NZG Ferredoxin Vapar_1014 ENOG4105E4R Precorrin-3B C17-methyltransferase Vapar_1018 ENOG4108P62 biosynthesis protein (CbiG) Vapar_1020 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Vapar_1021 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) Vapar_1022 ENOG41081F0 Precorrin-8x methylmutase Vapar_1024 ENOG4105CIA precorrin-4 C(11)-methyltransferase Vapar_1028 ENOG4105EJC lysr family transcriptional regulator Vapar_1030 ENOG4105CVE Lytic murein transglycosylase Vapar_1036 ENOG4105DDW LysR family Transcriptional regulator Vapar_1039 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Vapar_1040 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Vapar_1041 ENOG4105FGE Short-chain dehydrogenase reductase Sdr Vapar_1043 ENOG4105C26 Dehydrogenase Vapar_1044 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator Vapar_1045 ENOG4105DFW ABC transporter Vapar_1047 ENOG4108HWW ABC transporter Vapar_1048 ENOG4105C2J ABC transporter Vapar_1049 ENOG4107R9N ABC transporter Vapar_1050 ENOG41062B0 ABC transporter, permease Vapar_1053 ENOG4105CBN LysR family transcriptional regulator Vapar_1054 ENOG4105CHR reductase Vapar_1058 ENOG4107RRY Cyanophycin synthetase Vapar_1059 ENOG4108DIG cyanophycin synthetase Vapar_1060 ENOG4105BZ1 (ABC) transporter Vapar_1062 ENOG4105EXC Acyl-transferase Vapar_1063 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Vapar_1064 ENOG4105CQ0 ABC transporter Vapar_1067 ENOG4105DCM major facilitator superfamily Vapar_1068 ENOG4105HSS phospholipase C Vapar_1071 ENOG4105D7Q type ii secretion system Vapar_1072 ENOG4107QHF type ii secretion system protein e Vapar_1073 ENOG4105GVR general secretion pathway protein D Vapar_1081 ENOG4108VAU general secretion pathway protein G Vapar_1083 ENOG4105C7B Threonine dehydratase Vapar_1085 ENOG4108Z9W Outer membrane porin Vapar_1086 ENOG4108UKZ OsmC family Vapar_1087 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) Vapar_1088 ENOG4108Z9W Outer membrane porin Vapar_1089 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Vapar_1090 ENOG4105CH2 amidohydrolase Vapar_1091 ENOG4105DEF Extracellular solute-binding protein, family 5 Vapar_1092 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_1093 ENOG4105C3U ABC transporter Vapar_1094 ENOG4108JQ7 (ABC) transporter Vapar_1095 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Vapar_1096 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Vapar_1097 ENOG4105C4Y ABC transporter Vapar_1098 ENOG4107RCV ABC transporter, permease Vapar_1099 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_1102 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Vapar_1103 ENOG4107QP8 phosphohexose isomerase Vapar_1105 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Vapar_1106 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_1110 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Vapar_1111 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_1112 ENOG4105DEI Mannitol dehydrogenase Vapar_1113 ENOG4105CHR reductase Vapar_1114 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Vapar_1116 ENOG4105EQD regulatoR Vapar_1117 ENOG4105CMG Carbohydrate kinase Vapar_1118 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Vapar_1119 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Vapar_1121 ENOG4107RZC phospholipase d Vapar_1125 ENOG4105CHB tonB-dependent Receptor Vapar_1126 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Vapar_1128 ENOG4105D1S lipid A biosynthesis Vapar_1130 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Vapar_1132 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Vapar_1133 ENOG4105CRE cytochrome C Vapar_1134 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Vapar_1135 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Vapar_1136 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Vapar_1138 ENOG4105XQ6 frataxin-like protein Vapar_1139 ENOG4108JQC penicillin-binding protein 1A Vapar_1144 ENOG4105E4G Type IV pilus Vapar_1145 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Vapar_1146 ENOG4105D49 3-dehydroquinate synthase Vapar_1147 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Vapar_1154 ENOG4105DHJ ABC, transporter Vapar_1155 ENOG4105CY3 ABC transporter, permease Vapar_1156 ENOG4107PE3 Mammalian cell entry related domain protein Vapar_1160 ENOG4105DA5 (ABC) transporter Vapar_1161 ENOG4105E3A (ABC) transporter Vapar_1162 ENOG4105VFK BolA family Vapar_1163 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Vapar_1164 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Vapar_1165 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Vapar_1167 ENOG4105CIH Imidazole acetol-phosphate transaminase Vapar_1168 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Vapar_1170 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Vapar_1173 ENOG4105CK2 sodium dicarboxylate symporter Vapar_1175 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Vapar_1176 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Vapar_1177 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase Vapar_1179 ENOG4107YU2 histidine triad (hIT) protein Vapar_1180 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Vapar_1181 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Vapar_1182 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Vapar_1183 ENOG4105C0H protease Vapar_1184 ENOG4105CSH Transporter Vapar_1185 ENOG4107QNR UPF0135 protein Vapar_1186 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Vapar_1187 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Vapar_1192 ENOG4105D3Q Sugar transferase Vapar_1197 ENOG4105E3R (LipO)protein Vapar_1200 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Vapar_1201 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Vapar_1202 ENOG4105EIX cytochrome c1 Vapar_1203 ENOG4107MKT Stringent starvation protein a Vapar_1204 ENOG4105KB2 stringent starvation protein b Vapar_1207 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Vapar_1208 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Vapar_1210 ENOG4105D60 lipoprotein releasing system transmembrane protein Vapar_1211 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Vapar_1212 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Vapar_1213 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) Vapar_1222 ENOG4108MEJ flavin reductase domain protein Vapar_1225 ENOG4105CHR reductase Vapar_1226 ENOG4105DXM phenylacetic acid degradation protein Vapar_1227 ENOG4108IV0 ABC, transporter Vapar_1228 ENOG4105C0Z ABC transporter Vapar_1231 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Vapar_1232 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit Vapar_1233 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit Vapar_1234 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit Vapar_1235 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit Vapar_1237 ENOG4108ZJI phenylacetic acid degradation protein Vapar_1238 ENOG4108UKI Enoyl-CoA hydratase Vapar_1240 ENOG4108IG5 Transcriptional regulator Vapar_1241 ENOG4107QVM von Willebrand factor, type A Vapar_1243 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Vapar_1244 ENOG4105C0H protease Vapar_1245 ENOG4105EYA deoxyribonuclease Vapar_1248 ENOG4105I7M spermidine synthase Vapar_1249 ENOG4107QHF type ii secretion system protein e Vapar_1252 ENOG4105F04 LysR family Transcriptional regulator Vapar_1256 ENOG4105CHR reductase Vapar_1258 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Vapar_1260 ENOG4105EAM Na Pi-cotransporter Vapar_1262 ENOG4108IJ6 ABC transporter Vapar_1264 ENOG4108I5D sulfate abc transporter Vapar_1266 ENOG4105ETE Transcriptional regulator (LacI family Vapar_1267 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Vapar_1269 ENOG4105DTN riboflavin biosynthesis protein ribF Vapar_1274 ENOG4105X7H acyl-CoA dehydrogenase Vapar_1275 ENOG4108V3E phosphoribosylglycinamide formyltransferase Vapar_1281 ENOG4105W0E 50S ribosomal protein L33 Vapar_1282 ENOG4105KDC 50s ribosomal protein l28 Vapar_1283 ENOG4105C3M thioredoxin reductase Vapar_1285 ENOG4105CNU cell division protein FtsK Vapar_1286 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) Vapar_1287 ENOG4105D1H recombination factor protein RarA Vapar_1288 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_1289 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Vapar_1290 ENOG4105C0Z ABC transporter Vapar_1291 ENOG4108IV0 ABC, transporter Vapar_1293 ENOG4108EX3 reductase Vapar_1296 ENOG4105C6T cysteine synthase Vapar_1297 ENOG4105E09 nadh pyrophosphatase Vapar_1298 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) Vapar_1299 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Vapar_1300 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Vapar_1301 ENOG4105D1Q UPF0246 protein Vapar_1303 ENOG4108MUZ hydrolase Vapar_1304 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Vapar_1305 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Vapar_1308 ENOG4105CXK mandelate racemase muconate lactonizing Vapar_1312 ENOG4105C1G acyl-Coa dehydrogenase Vapar_1314 ENOG4105CC9 acyl-Coa dehydrogenase Vapar_1316 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_1323 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Vapar_1330 ENOG4105CSH Transporter Vapar_1331 ENOG4105DMF Dehydrogenase Vapar_1332 ENOG4108PZW LysR family Transcriptional regulator Vapar_1335 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) Vapar_1336 ENOG4105EMU Dehydrogenase Vapar_1337 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Vapar_1338 ENOG4105CIH Imidazole acetol-phosphate transaminase Vapar_1341 ENOG4105DJ2 Major Facilitator Superfamily Vapar_1342 ENOG4105JXH GntR family transcriptional regulator Vapar_1343 ENOG4105BZ4 penicillin-binding protein Vapar_1345 ENOG410829K Lysine exporter protein (Lyse ygga) Vapar_1348 ENOG4108Z7F N-acetyltransferase Vapar_1349 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) Vapar_1354 ENOG4108UVJ appr-1-p processing domain protein Vapar_1361 ENOG4105CH7 arginosuccinase Vapar_1362 ENOG4108HRK Histidine kinase Vapar_1363 ENOG4108NEV two component transcriptional regulator, LytTR family Vapar_1364 ENOG4105DSF transport protein Vapar_1370 ENOG4105DUM transcriptional regulator, lysR family Vapar_1373 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Vapar_1374 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Vapar_1378 ENOG4105C03 ribonuclease Vapar_1379 ENOG4105EI2 Pseudouridine synthase Vapar_1382 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Vapar_1383 ENOG4106UW1 Major Facilitator superfamily Vapar_1384 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Vapar_1385 ENOG4108UHJ MAF-like protein Vapar_1386 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein Vapar_1387 ENOG4105VGS 50s ribosomal protein l32 Vapar_1388 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Vapar_1389 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Vapar_1390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Vapar_1391 ENOG4105CHR reductase Vapar_1392 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Vapar_1393 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Vapar_1398 ENOG4105C0H protease Vapar_1399 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Vapar_1400 ENOG4105C3F Signal peptidase i Vapar_1402 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Vapar_1403 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Vapar_1404 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) Vapar_1405 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Vapar_1406 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Vapar_1407 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Vapar_1408 ENOG4108VKG metal-dependent hydrolase Vapar_1409 ENOG4105R8A Heat shock protein Vapar_1410 ENOG4105CRK lysyL-tRNA synthetase Vapar_1412 ENOG4108VIA integral membrane protein Vapar_1413 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Vapar_1414 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Vapar_1415 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Vapar_1416 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Vapar_1417 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Vapar_1419 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Vapar_1420 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Vapar_1421 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Vapar_1422 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Vapar_1425 ENOG4105BZN citrate synthase Vapar_1426 ENOG41060IS Flavinator of succinate dehydrogenase Vapar_1427 ENOG4105E33 succinate dehydrogenase Vapar_1428 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Vapar_1431 ENOG4105FDP GntR family transcriptional regulator Vapar_1432 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Vapar_1433 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Vapar_1436 ENOG4107QIJ Aconitate hydratase 2 Vapar_1437 ENOG4107QPN acyl-Coa dehydrogenase Vapar_1440 ENOG4107QM5 aconitate hydratase Vapar_1443 ENOG4105CE1 Ferrous iron transport protein b Vapar_1445 ENOG4105MSY salicylate hydroxylase Vapar_1447 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) Vapar_1449 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Vapar_1451 ENOG4105DBV ornithine carbamoyltransferase Vapar_1452 ENOG4105C8Y Acetylornithine aminotransferase Vapar_1454 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) Vapar_1455 ENOG4105CJR Integral membrane protein (MviN Vapar_1458 ENOG4105GRZ Ycii-related protein Vapar_1459 ENOG4105GRZ Ycii-related protein Vapar_1460 ENOG4105CHP RNA polymerase Vapar_1461 ENOG4105E7U AraC family transcriptional regulator Vapar_1465 ENOG4105CXB phosphoribosylaminoimidazole synthetase Vapar_1466 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) Vapar_1467 ENOG4105DJ0 Poly(A) Polymerase Vapar_1468 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Vapar_1469 ENOG4107GRR phosphate transport regulator Vapar_1470 ENOG4107QXV Phosphate transporter Vapar_1473 ENOG4105K5M 30s ribosomal protein S16 Vapar_1474 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Vapar_1475 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Vapar_1476 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Vapar_1477 ENOG4105P8F nudix hydrolase Vapar_1478 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Vapar_1479 ENOG4105E45 Histidinol-phosphate aminotransferase Vapar_1480 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Vapar_1481 ENOG41090A4 Pterin carbinolamine dehydratase Vapar_1482 ENOG4105D0M Protease HtpX homolog Vapar_1483 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) Vapar_1484 ENOG4105C1J atp-dependent rna helicase Vapar_1485 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Vapar_1486 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Vapar_1493 ENOG4105FUY alpha subunit Vapar_1495 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_1498 ENOG4106IPI cyclase, family Vapar_1499 ENOG4105CHR reductase Vapar_1501 ENOG4105CP9 extracellular ligand-binding receptor Vapar_1505 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_1506 ENOG4105C0Z ABC transporter Vapar_1507 ENOG4108IV0 ABC, transporter Vapar_1509 ENOG4105CHR reductase Vapar_1510 ENOG4105DTD Dehydrogenase Vapar_1531 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_1534 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) Vapar_1535 ENOG41090JD Blue (Type 1) copper domain protein Vapar_1536 ENOG4105C4R Atp-dependent dna helicase Vapar_1540 ENOG4105CUV Homoserine Kinase Vapar_1542 ENOG4105C2M dna polymerase I Vapar_1545 ENOG4105MWK D-amino acid dehydrogenase, small subunit Vapar_1546 ENOG4107RP9 extracellular solute-binding protein, family 3 Vapar_1548 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Vapar_1558 ENOG4105FC8 fad dependent oxidoreductase Vapar_1561 ENOG4108NST exported protein Vapar_1564 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Vapar_1566 ENOG4105KHC sulfurtransferase Vapar_1569 ENOG41086K9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Vapar_1570 ENOG4105CTB Polyprenyl synthetase Vapar_1571 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Vapar_1572 ENOG4105CH5 extracellular solute-binding protein, family 7 Vapar_1573 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_1575 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Vapar_1576 ENOG41079KZ Major Facilitator Superfamily Vapar_1577 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Vapar_1579 ENOG4105EVZ LysR family transcriptional regulator Vapar_1580 ENOG4108K85 Transcriptional regulator Vapar_1582 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_1584 ENOG4105C0Z ABC transporter Vapar_1585 ENOG4108IV0 ABC, transporter Vapar_1586 ENOG4105CE7 Amidase, hydantoinase carbamoylase family Vapar_1589 ENOG4108JJB ABC transporter Vapar_1596 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Vapar_1599 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Vapar_1600 ENOG4105KJM monovalent cation h antiporter subunit g Vapar_1601 ENOG4105W4C monovalent cation H antiporter subunit F Vapar_1603 ENOG4107R4Z monovalent cation h antiporter subunit d Vapar_1604 ENOG4108ZE9 Monovalent cation H antiporter subunit C Vapar_1605 ENOG4105D65 subunit l Vapar_1606 ENOG4107Z6W Protein CrcB homolog Vapar_1607 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_1609 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_1611 ENOG4105CFV Tetratricopeptide repeat protein Vapar_1614 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Vapar_1615 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Vapar_1618 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Vapar_1620 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Vapar_1621 ENOG4105UYK outer membrane protein a Vapar_1622 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Vapar_1623 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Vapar_1624 ENOG4106R49 Methyltransferase Vapar_1626 ENOG4105I08 Pseudouridine synthase Vapar_1631 ENOG4107TH8 cina domain protein Vapar_1632 ENOG4105C5F glutamine synthetase Vapar_1634 ENOG4105CUX Signal transduction histidine kinase Vapar_1635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Vapar_1637 ENOG4105CGK Exodeoxyribonuclease III Vapar_1642 ENOG4105EGI Transcriptional regulator Vapar_1643 ENOG4107YNJ LysR family Transcriptional regulator Vapar_1644 ENOG4105CMJ mandelate racemase muconate lactonizing Vapar_1647 ENOG4108VHC Short-chain dehydrogenase reductase Sdr Vapar_1649 ENOG4108DN8 FAD dependent oxidoreductase Vapar_1657 ENOG4105EHU Circadian clock protein KaiC Vapar_1658 ENOG4105BZU Histidine kinase Vapar_1659 ENOG4107UXM Membrane Vapar_1660 ENOG4105DQE DNA ligase Vapar_1663 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) Vapar_1664 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Vapar_1668 ENOG4105CQB FAD linked oxidase domain protein Vapar_1670 ENOG4107S2Z UPF0761 membrane protein Vapar_1672 ENOG4105K63 Thioredoxin Vapar_1673 ENOG4105K4T epimerase Vapar_1674 ENOG4105EMY transcriptional regulator Vapar_1677 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Vapar_1681 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Vapar_1682 ENOG4106NZI LysR family Transcriptional regulator Vapar_1687 ENOG4108K3M Rieske [2Fe-2S] domain Vapar_1690 ENOG4107QVI Methyltransferase, type 11 Vapar_1694 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Vapar_1698 ENOG4105HP8 regulator of competence-specific genes Vapar_1699 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase Vapar_1701 ENOG4105C4W S-formylglutathione hydrolase Vapar_1702 ENOG4105EBM Alpha Beta Hydrolase Fold protein Vapar_1703 ENOG4107QPD alcohol dehydrogenase Vapar_1707 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Vapar_1708 ENOG4105ED1 spovr family Vapar_1709 ENOG4106AKX UPF0229 protein Vapar_1710 ENOG4105CYN Serine protein kinase Vapar_1711 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Vapar_1712 ENOG4105CFG Acts as a chaperone (By similarity) Vapar_1713 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Vapar_1714 ENOG4108V1T peptidylprolyl cis-trans isomerase Vapar_1716 ENOG4105DJ4 phosphatidylserine decarboxylase Vapar_1718 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Vapar_1720 ENOG4105CHR reductase Vapar_1721 ENOG4105CTX dehydratase Vapar_1724 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_1726 ENOG4105E9Z Nad-dependent epimerase dehydratase Vapar_1727 ENOG4105JXH GntR family transcriptional regulator Vapar_1729 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase Vapar_1732 ENOG4105C26 Dehydrogenase Vapar_1734 ENOG4105CWB LysR family transcriptional Regulator Vapar_1735 ENOG4105E90 ABC transporter Vapar_1738 ENOG4107QWP ABC-2 type transporter Vapar_1739 ENOG4107QWP ABC-2 type transporter Vapar_1740 ENOG4105CJ1 ABC, transporter Vapar_1743 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Vapar_1744 ENOG4108RXX maleylacetoacetate isomerase Vapar_1746 ENOG4108WYP Transcriptional regulator Vapar_1750 ENOG4105C0Z ABC transporter Vapar_1751 ENOG4108IV0 ABC, transporter Vapar_1755 ENOG4108W5M transcriptional regulator Vapar_1756 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Vapar_1757 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_1761 ENOG4105C2C drug resistance transporter, Bcr CflA Vapar_1762 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Vapar_1763 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Vapar_1764 ENOG4107S2Z UPF0761 membrane protein Vapar_1766 ENOG4108WFY phasin family Vapar_1768 ENOG4105DGU Histone deacetylase Vapar_1771 ENOG4105VDW Csbd family Vapar_1772 ENOG4107RH7 Nicotinate phosphoribosyltransferase Vapar_1774 ENOG4105C5I Dehydrogenase Vapar_1775 ENOG4107QSV RmuC domain protein Vapar_1778 ENOG4105E39 Enoyl-CoA hydratase Vapar_1779 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Vapar_1782 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Vapar_1783 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Vapar_1786 ENOG4105EJC lysr family transcriptional regulator Vapar_1787 ENOG4105EBM Alpha Beta Hydrolase Fold protein Vapar_1788 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Vapar_1790 ENOG4107TF3 peptidylprolyl cis-trans isomerase Vapar_1797 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Vapar_1798 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Vapar_1799 ENOG4108K5P (LipO)protein Vapar_1800 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Vapar_1801 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Vapar_1802 ENOG4108MN8 Membrane Vapar_1803 ENOG4108ZJF Glcg protein Vapar_1805 ENOG4105M8F Biopolymer transport protein exbD tolR Vapar_1808 ENOG4108IU3 tonb-dependent siderophore receptor Vapar_1809 ENOG4107E2E PKHD-type hydroxylase Vapar_1812 ENOG4108UQY Iron-storage protein Vapar_1814 ENOG4108JU3 Alkyl hydroperoxide reductase Vapar_1815 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Vapar_1816 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Vapar_1818 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Vapar_1820 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Vapar_1821 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Vapar_1822 ENOG4105CDU Replicative dna helicase Vapar_1827 ENOG4108IAB Phoh family Vapar_1828 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Vapar_1830 ENOG4105CHM Aminotransferase Vapar_1831 ENOG4105D6E homoserine dehydrogenase Vapar_1832 ENOG4105D98 threonine synthase Vapar_1833 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Vapar_1834 ENOG4105CVM Molybdenum cofactor synthesis domain protein Vapar_1835 ENOG4105M00 molybdopterin converting factor, subunit 1 Vapar_1836 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Vapar_1837 ENOG4108ZAF Molybdopterin Vapar_1839 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Vapar_1841 ENOG4105CHU acetyl-coa acetyltransferase Vapar_1842 ENOG4108YZN class I peptide chain release factor Vapar_1844 ENOG4105CHH sulfate transporter Vapar_1846 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Vapar_1847 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Vapar_1854 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Vapar_1855 ENOG4105T0Z Conserved Protein Vapar_1861 ENOG4107XKF NMT1 THI5 Like Domain Protein Vapar_1862 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Vapar_1864 ENOG4108W9H Tetr family transcriptional regulator Vapar_1869 ENOG4108I9X Isocitrate lyase Vapar_1870 ENOG4105C22 threonyL-tRNA synthetase Vapar_1871 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Vapar_1872 ENOG4105VJV 50s ribosomal protein L35 Vapar_1873 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Vapar_1874 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Vapar_1875 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Vapar_1876 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Vapar_1878 ENOG41067QW Transcriptional regulator Vapar_1883 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_1886 ENOG4105CDA abc transporter atp-binding protein Vapar_1887 ENOG4105DRP amino acid AbC transporter Vapar_1891 ENOG4105D7W serine acetyltransferase Vapar_1893 ENOG4105ESN nucleotide-binding protein Vapar_1894 ENOG4105C9B Cysteine desulfurase Vapar_1899 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_1902 ENOG4108UZX fmn reductase Vapar_1905 ENOG4105D01 (LipO)protein Vapar_1908 ENOG4105CPU Monooxygenase Vapar_1910 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_1911 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component Vapar_1914 ENOG4105BZU Histidine kinase Vapar_1915 ENOG4105CC0 LysR family Transcriptional regulator Vapar_1916 ENOG4105CHJ isochorismatase hydrolase Vapar_1926 ENOG4107QQG Dehydrogenase Vapar_1927 ENOG4107R5Z Oxidoreductase domain protein Vapar_1928 ENOG4105J5G Transferase hexapeptide repeat containing protein Vapar_1929 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Vapar_1934 ENOG4105D3Q Sugar transferase Vapar_1937 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Vapar_1942 ENOG4105E3R (LipO)protein Vapar_1945 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Vapar_1947 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_1948 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_1949 ENOG4105ETE Transcriptional regulator (LacI family Vapar_1951 ENOG4105C26 Dehydrogenase Vapar_1952 ENOG4105CTX dehydratase Vapar_1953 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_1960 ENOG4105CAU Arsenical resistance protein, ArsH Vapar_1963 ENOG4105D6J arsenicaL-resistance protein Vapar_1965 ENOG4105BZU Histidine kinase Vapar_1966 ENOG4107QHF type ii secretion system protein e Vapar_1967 ENOG4105BZU Histidine kinase Vapar_1968 ENOG4105CG3 alpha amylase, catalytic region Vapar_1969 ENOG4105CG3 alpha amylase, catalytic region Vapar_1978 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Vapar_1979 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) Vapar_1980 ENOG4105CG3 alpha amylase, catalytic region Vapar_1983 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Vapar_1984 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) Vapar_1991 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Vapar_1992 ENOG4105BZ9 Cytochrome C oxidase, subunit I Vapar_1993 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Vapar_2001 ENOG41080XQ Signal transduction protein with cbs domains Vapar_2002 ENOG4105GTG Isochorismatase Vapar_2011 ENOG4105CJP fad dependent oxidoreductase Vapar_2014 ENOG4107RZC phospholipase d Vapar_2015 ENOG4108K5P (LipO)protein Vapar_2016 ENOG4108RH0 Crea protein Vapar_2017 ENOG4105E09 nadh pyrophosphatase Vapar_2020 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Vapar_2022 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class Vapar_2023 ENOG4105CHU acetyl-coa acetyltransferase Vapar_2024 ENOG4108KB2 LysR family Transcriptional regulator Vapar_2026 ENOG4108M9J MaoC like domain protein Vapar_2030 ENOG4105CEV competence damage-inducible protein Vapar_2031 ENOG4105CHR reductase Vapar_2032 ENOG4105CK2 sodium dicarboxylate symporter Vapar_2033 ENOG4105CKD glutathione-regulated potassium-efflux system protein Vapar_2035 ENOG4105D6E homoserine dehydrogenase Vapar_2044 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF Vapar_2047 ENOG4105EW9 transcriptional regulator AsnC family Vapar_2048 ENOG4105C7K acetolactate synthase Vapar_2054 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Vapar_2071 ENOG4108EU3 peptide transport system, permease Vapar_2072 ENOG4108JQ5 ABC transporter Vapar_2075 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Vapar_2078 ENOG4105FEQ ParB domain protein nuclease Vapar_2087 ENOG4107QJE Chromosome Partitioning Protein Vapar_2092 ENOG4105DUM transcriptional regulator, lysR family Vapar_2094 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_2096 ENOG4105CSU acyl-Coa dehydrogenase Vapar_2097 ENOG4107RSM transcriptional regulator Vapar_2098 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Vapar_2102 ENOG4108IV0 ABC, transporter Vapar_2103 ENOG4105C0Z ABC transporter Vapar_2104 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Vapar_2105 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_2106 ENOG4105C87 Aminotransferase class I and II Vapar_2107 ENOG4107ZXU DSBA oxidoreductase Vapar_2122 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Vapar_2126 ENOG4105DRR Transcriptional regulator, GntR family Vapar_2129 ENOG4105DJT lAO AO transport system ATPase Vapar_2130 ENOG4107QX3 carboxylase Vapar_2131 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Vapar_2132 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Vapar_2135 ENOG4105FDR Membrane Vapar_2137 ENOG4108R3D Electron transport complex Vapar_2139 ENOG4105CGF Aromatic amino acid aminotransferase Vapar_2140 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Vapar_2141 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Vapar_2142 ENOG4105C3J Cysteine desulfurase Vapar_2143 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Vapar_2146 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB Vapar_2147 ENOG4108ZIT Ferredoxin, 2FE-2S Vapar_2148 ENOG4107RZZ dna polymerase iii epsilon subunit Vapar_2152 ENOG4105D5U fad dependent oxidoreductase Vapar_2155 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Vapar_2156 ENOG4105E66 phosphoriboisomerase A Vapar_2158 ENOG4105DGW oligopeptidase A Vapar_2159 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Vapar_2160 ENOG4108ZXC Two component transcriptional regulator, luxr family Vapar_2161 ENOG4105BZU Histidine kinase Vapar_2162 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Vapar_2163 ENOG4107QSN dihydrolipoamide acetyltransferase Vapar_2164 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Vapar_2165 ENOG4107QN2 dihydrolipoyl dehydrogenase Vapar_2166 ENOG4105K4H Nlp p60 protein Vapar_2167 ENOG4105D8V Glucose sorbosone dehydrogenase Vapar_2170 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Vapar_2171 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Vapar_2172 ENOG4105C7S Dehydrogenase Vapar_2173 ENOG4107QN2 dihydrolipoyl dehydrogenase Vapar_2174 ENOG4105D6Z AFG1 family ATPase Vapar_2178 ENOG4105DVT helicase Vapar_2180 ENOG4105C34 Pseudouridine synthase Vapar_2181 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Vapar_2182 ENOG4105FE9 pseudouridine synthase Vapar_2183 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Vapar_2184 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Vapar_2187 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Vapar_2188 ENOG4105CUT histidyl-tRNA synthetase Vapar_2191 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Vapar_2192 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Vapar_2193 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Vapar_2194 ENOG4107QJR hflk protein Vapar_2195 ENOG4105EPW hflc protein Vapar_2197 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Vapar_2198 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Vapar_2203 ENOG4105C28 cystathionine Vapar_2205 ENOG4108UJV acyl-CoA thioesterase i Vapar_2206 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Vapar_2208 ENOG4105C2N RNA methyltransferase TrmH family group 3 Vapar_2211 ENOG4108Z7F N-acetyltransferase Vapar_2212 ENOG4105NI3 Protein of unknown function (DUF3237) Vapar_2213 ENOG4105CPC Aldo Keto reductase Vapar_2214 ENOG4105CAH Chromate Vapar_2216 ENOG4107S2Z UPF0761 membrane protein Vapar_2225 ENOG4105CCT upf0313 protein Vapar_2229 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F Vapar_2230 ENOG4105K6S Short-chain dehydrogenase reductase Sdr Vapar_2234 ENOG41060WC Enoyl-CoA hydratase Vapar_2259 ENOG4105VS8 Flagellar biosynthetic protein fliq Vapar_2260 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Vapar_2261 ENOG4105D00 flagellar biosynthetic protein flhB Vapar_2262 ENOG4105D7B Flagellar biosynthesis protein flha Vapar_2263 ENOG4105CGA flagellar basal-body rod protein FlgG Vapar_2264 ENOG4105CGA flagellar basal-body rod protein FlgG Vapar_2266 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Vapar_2267 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Vapar_2269 ENOG4108ZC9 flagellar basal-body rod protein flgc Vapar_2270 ENOG41084DA flagellar hook-basal body complex protein fliE Vapar_2271 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Vapar_2277 ENOG410822I Flagellar hook capping protein Vapar_2278 ENOG4105BZE flagellar hook protein, FlgE Vapar_2280 ENOG4105DD5 Flagellar motor switch protein Vapar_2282 ENOG4105CN7 Flagellar biosynthetic protein FliP Vapar_2283 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Vapar_2295 ENOG4105F2I Transposase Vapar_2303 ENOG4105CYM Glutathione S-transferase Vapar_2304 ENOG4105C3M thioredoxin reductase Vapar_2310 ENOG4105C9X ppx gppa phosphatase Vapar_2311 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Vapar_2312 ENOG4105C8U phosphate abc transporter Vapar_2313 ENOG4105E2Z phosphate ABC transporter (Permease Vapar_2314 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Vapar_2317 ENOG4105BZU Histidine kinase Vapar_2318 ENOG4107QI1 Mate efflux family protein Vapar_2320 ENOG4105NRA 50s ribosomal protein l31 type b Vapar_2321 ENOG4105D9R oxidoreductase Vapar_2322 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Vapar_2323 ENOG4105K63 Thioredoxin Vapar_2325 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Vapar_2330 ENOG4107QMP dna polymerase iii subunits gamma and tau Vapar_2331 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Vapar_2332 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Vapar_2334 ENOG4105D2X ABC transporter substrate-binding protein Vapar_2336 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_2337 ENOG4105E9H Lytic Murein transglycosylase Vapar_2338 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Vapar_2339 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) Vapar_2340 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Vapar_2341 ENOG4105CVM Molybdenum cofactor synthesis domain protein Vapar_2342 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Vapar_2343 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Vapar_2344 ENOG4105C26 Dehydrogenase Vapar_2346 ENOG4107RZC phospholipase d Vapar_2358 ENOG4105F0N pyrophosphate phospho-hydrolase Vapar_2360 ENOG4105C4K Nad synthetase Vapar_2361 ENOG4108YZA Nitrogen regulatory protein pii Vapar_2362 ENOG4108URH decarboxylase Vapar_2363 ENOG41080IJ Diacylglycerol kinase Vapar_2368 ENOG4105C7K acetolactate synthase Vapar_2369 ENOG4108ZP8 Acetolactate synthase small subunit Vapar_2371 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Vapar_2372 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Vapar_2373 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Vapar_2374 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Vapar_2375 ENOG41061WM D-Alanyl-D-Alanine Vapar_2376 ENOG41069M3 Transcriptional regulator Vapar_2377 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate Vapar_2378 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Vapar_2382 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase Vapar_2383 ENOG4107HP6 Transcriptional regulator Vapar_2384 ENOG4105XJC Two component transcriptional regulator (Winged helix family Vapar_2385 ENOG4105DHQ Histidine kinase Vapar_2386 ENOG4105C0H protease Vapar_2394 ENOG4105CNM Receptor Vapar_2395 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Vapar_2396 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Vapar_2402 ENOG4105CAY ferredoxin--nadp reductase Vapar_2403 ENOG4108Z4U Ferredoxin Vapar_2404 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) Vapar_2409 ENOG4108KQ5 Integrase catalytic subunit Vapar_2414 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Vapar_2418 ENOG4105C0Z ABC transporter Vapar_2420 ENOG4108IV0 ABC, transporter Vapar_2425 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Vapar_2473 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Vapar_2501 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant Vapar_2504 ENOG4107S11 squalene-associated FAD-dependent desaturase Vapar_2505 ENOG4105FE1 phytoene synthase Vapar_2508 ENOG4105ENT Efflux transporter rnd family, mfp subunit Vapar_2510 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Vapar_2511 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Vapar_2512 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Vapar_2513 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Vapar_2517 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Vapar_2519 ENOG4105GIJ Glycine betaine Vapar_2520 ENOG4108HQS Glycine betaine Vapar_2521 ENOG4108IJ7 Glycine betaine Vapar_2523 ENOG4108RYK Nad-dependent epimerase dehydratase Vapar_2524 ENOG4105EJC lysr family transcriptional regulator Vapar_2525 ENOG4108TEB UPF0114 protein Vapar_2526 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Vapar_2528 ENOG4105W2Z cytochrome C, class I Vapar_2530 ENOG4105C01 Dihydroxy-acid dehydratase Vapar_2531 ENOG4106NZI LysR family Transcriptional regulator Vapar_2532 ENOG4105CBN LysR family transcriptional regulator Vapar_2533 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Vapar_2534 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Vapar_2535 ENOG4105DRR Transcriptional regulator, GntR family Vapar_2538 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_2541 ENOG4105ES4 Nitrilase Vapar_2542 ENOG41063TF transcriptional regulator (AraC Vapar_2544 ENOG4105HF0 Membrane Vapar_2547 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Vapar_2548 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Vapar_2549 ENOG4108YZT Adenosylcobinamide kinase Vapar_2551 ENOG4105EHG Permease protein Vapar_2552 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Vapar_2553 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Vapar_2554 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Vapar_2555 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Vapar_2556 ENOG4105CIH Imidazole acetol-phosphate transaminase Vapar_2565 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Vapar_2566 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Vapar_2567 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Vapar_2570 ENOG4105CHR reductase Vapar_2571 ENOG4105CSM endonuclease III Vapar_2572 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Vapar_2577 ENOG4105EAC phosphoserine phosphatase Vapar_2578 ENOG4108JA2 transcriptioN-repair coupling factor Vapar_2579 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) Vapar_2580 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) Vapar_2581 ENOG4105E0F Histidine kinase Vapar_2582 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Vapar_2585 ENOG4105DTD Dehydrogenase Vapar_2587 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Vapar_2589 ENOG4108NVM synthesis repressor PhaR Vapar_2590 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Vapar_2595 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Vapar_2596 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Vapar_2599 ENOG4105CE9 30S ribosomal protein S2 Vapar_2600 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Vapar_2601 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Vapar_2602 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Vapar_2604 ENOG4105KNE Phosphatidate cytidylyltransferase Vapar_2605 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Vapar_2606 ENOG4105DZP Membrane-associated zinc metalloprotease Vapar_2607 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Vapar_2609 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Vapar_2610 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Vapar_2611 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Vapar_2612 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Vapar_2613 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Vapar_2617 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Vapar_2619 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Vapar_2622 ENOG4105HBR Rna-binding protein Vapar_2623 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Vapar_2624 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Vapar_2625 ENOG4105EEI dihydropteroate synthase Vapar_2626 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Vapar_2628 ENOG4105C1G acyl-Coa dehydrogenase Vapar_2630 ENOG4105IJJ transcriptional regulator, crp fnr family Vapar_2631 ENOG4108UKI Enoyl-CoA hydratase Vapar_2632 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Vapar_2633 ENOG4108RWP Major Facilitator Superfamily protein Vapar_2634 ENOG4108M3J Dehydrogenase Vapar_2636 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Vapar_2637 ENOG4105HDK L-asparaginase Vapar_2638 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Vapar_2639 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Vapar_2640 ENOG4105W49 UPF0434 protein Vapar_2641 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Vapar_2642 ENOG4108ZZF transport protein (ExbD) Vapar_2644 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Vapar_2645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Vapar_2650 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Vapar_2651 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Vapar_2652 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Vapar_2653 ENOG4105CJB Exodeoxyribonuclease I Vapar_2654 ENOG4105DZC cytosine deaminase Vapar_2657 ENOG4105UIB (ABC) transporter Vapar_2658 ENOG4108JQ9 ABC transporter Vapar_2659 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Vapar_2660 ENOG4107TFB basic membrane Vapar_2661 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Vapar_2666 ENOG4105NCT RNA Polymerase Vapar_2668 ENOG4105D7A ATP-binding protein Vapar_2671 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Vapar_2678 ENOG4105CHR reductase Vapar_2682 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Vapar_2683 ENOG4105CDY transcriptional regulatory protein Vapar_2684 ENOG4105C12 Phosphoribosylglycinamide synthetase Vapar_2685 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) Vapar_2686 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Vapar_2687 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Vapar_2688 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Vapar_2689 ENOG4108Z03 MAF-like protein Vapar_2690 ENOG4105C03 ribonuclease Vapar_2691 ENOG4105BZ1 (ABC) transporter Vapar_2692 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Vapar_2693 ENOG4105KCK Peptidoglycan-associated lipoprotein Vapar_2695 ENOG4105CUZ uba thif-type nad fad binding protein Vapar_2715 ENOG4105C5H ABC transporter Vapar_2716 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) Vapar_2717 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Vapar_2718 ENOG4105CZX twitching motility protein Vapar_2719 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Vapar_2721 ENOG410829K Lysine exporter protein (Lyse ygga) Vapar_2722 ENOG4108EKC n-acetylglutamate synthase Vapar_2723 ENOG4105CQ7 ATP-dependent helicase Vapar_2725 ENOG4105CHM Aminotransferase Vapar_2726 ENOG4107R11 Transcriptional regulator Vapar_2730 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Vapar_2733 ENOG4105CP9 extracellular ligand-binding receptor Vapar_2738 ENOG4105CXN decarboxylase Vapar_2740 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Vapar_2741 ENOG4105E43 Extracellular solute-binding protein, family 5 Vapar_2742 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component Vapar_2743 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component Vapar_2744 ENOG4108JQ5 ABC transporter Vapar_2745 ENOG4105CBP Major Facilitator Vapar_2746 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Vapar_2747 ENOG4105CHV Transcription elongation factor NusA Vapar_2749 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Vapar_2750 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Vapar_2757 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Vapar_2758 ENOG4108Z1B Cyclase dehydrase Vapar_2759 ENOG4105VDB UPF0125 protein Vapar_2761 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Vapar_2764 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Vapar_2766 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr Vapar_2768 ENOG4105CYW agmatinase Vapar_2769 ENOG4105D74 hydrolase Vapar_2771 ENOG4108JU7 Transcriptional regulator Vapar_2775 ENOG4105CR4 methylisocitrate lyase Vapar_2778 ENOG4108W5M transcriptional regulator Vapar_2780 ENOG4105KME endoribonuclease L-psp Vapar_2782 ENOG4105DIK (ABC) transporter Vapar_2783 ENOG4105CC5 ABC transporter Vapar_2784 ENOG4105DSE periplasmic solute binding protein Vapar_2790 ENOG4105BZU Histidine kinase Vapar_2791 ENOG4108ZXC Two component transcriptional regulator, luxr family Vapar_2796 ENOG4108Z6B deaminase Vapar_2797 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A Vapar_2802 ENOG4105BZU Histidine kinase Vapar_2803 ENOG4107Z5C methylesterase Vapar_2804 ENOG4105BZU Histidine kinase Vapar_2806 ENOG4105DVT helicase Vapar_2811 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Vapar_2812 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Vapar_2813 ENOG4105CPC Aldo Keto reductase Vapar_2814 ENOG4105CF7 AraC family transcriptional regulator Vapar_2816 ENOG4105C59 p-type ATPase Vapar_2818 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Vapar_2824 ENOG4105D4P Coproporphyrinogen iii oxidase Vapar_2826 ENOG4107QRI Phosphoketolase Vapar_2829 ENOG41080TK Universal stress protein Vapar_2835 ENOG4105CWU Biogenesis protein Vapar_2845 ENOG4105D9P serine threonine protein kinase Vapar_2847 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Vapar_2849 ENOG4108IFG nitrite reductase, (NAD(P)H) Vapar_2850 ENOG4105WKW Pfam:DUF1458 Vapar_2855 ENOG4105F8V Hydrolase, tatD family Vapar_2857 ENOG4107QRG dna polymerase iii Vapar_2858 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Vapar_2859 ENOG4105HHA aminodeoxychorismate lyase Vapar_2860 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Vapar_2864 ENOG4105C0A alcohol dehydrogenase Vapar_2865 ENOG4105CS6 Rhs element vgr protein Vapar_2875 ENOG4105BZM domain protein Vapar_2876 ENOG4105C6F GntR Family Transcriptional Regulator Vapar_2879 ENOG4105CPQ Dehydrogenase Vapar_2880 ENOG4105E5Q amino acid AbC transporter Vapar_2881 ENOG4105E5Q amino acid AbC transporter Vapar_2883 ENOG4105CXK mandelate racemase muconate lactonizing Vapar_2884 ENOG4105DEI Mannitol dehydrogenase Vapar_2889 ENOG4107QJQ Mate efflux family protein Vapar_2893 ENOG4105DY2 Paraquat-inducible protein b Vapar_2894 ENOG4105F1S paraquat-inducible protein a Vapar_2895 ENOG4105F1S paraquat-inducible protein a Vapar_2896 ENOG4105C0R drug resistance transporter emrb qaca subfamily Vapar_2897 ENOG4105C2C drug resistance transporter, Bcr CflA Vapar_2898 ENOG4105D0M Protease HtpX homolog Vapar_2901 ENOG4105ETT transcriptional Regulator, LysR family Vapar_2904 ENOG4105CQB FAD linked oxidase domain protein Vapar_2909 ENOG4105HEI LysR family (Transcriptional regulator Vapar_2910 ENOG4105F27 Major Facilitator Vapar_2911 ENOG4105CPC Aldo Keto reductase Vapar_2912 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Vapar_2916 ENOG4105CSU acyl-Coa dehydrogenase Vapar_2917 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Vapar_2919 ENOG4105CHR reductase Vapar_2922 ENOG4105CSU acyl-Coa dehydrogenase Vapar_2923 ENOG4105CHU acetyl-coa acetyltransferase Vapar_2924 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Vapar_2925 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Vapar_2926 ENOG4108IV0 ABC, transporter Vapar_2927 ENOG4105C0Z ABC transporter Vapar_2929 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_2932 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_2933 ENOG4105EBR Carboxylesterase Vapar_2935 ENOG4105CNG UPF0061 protein Vapar_2936 ENOG4105E0X reductase Vapar_2937 ENOG4107835 probably involved in intracellular septation (By similarity) Vapar_2939 ENOG4107TF3 peptidylprolyl cis-trans isomerase Vapar_2940 ENOG4108ETH Formylglycinamide ribotide synthetase Vapar_2941 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Vapar_2942 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Vapar_2944 ENOG4105DRP amino acid AbC transporter Vapar_2945 ENOG4105EZ7 amino acid ABC transporter Vapar_2946 ENOG4107QXX ABC transporter Vapar_2948 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Vapar_2950 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Vapar_2952 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Vapar_2957 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) Vapar_2958 ENOG4108IJ6 ABC transporter Vapar_2959 ENOG4105ECW sulfate abc transporter Vapar_2960 ENOG4108I5D sulfate abc transporter Vapar_2961 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Vapar_2963 ENOG4105D3R alkyl hydroperoxide reductase Vapar_2964 ENOG4105JQN Transcriptional regulator Vapar_2965 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Vapar_2967 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Vapar_2970 ENOG4105D7W serine acetyltransferase Vapar_2973 ENOG4105E2Y ABC, transporter Vapar_2974 ENOG4105GVF (ABC) transporter Vapar_2975 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_2976 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Vapar_2978 ENOG4105GVF (ABC) transporter Vapar_2980 ENOG4108UZX fmn reductase Vapar_2981 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Vapar_2982 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) Vapar_2983 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Vapar_2987 ENOG4105BZU Histidine kinase Vapar_2988 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Vapar_2989 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) Vapar_2990 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Vapar_2992 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Vapar_2993 ENOG4107R1Y fructose-bisphosphate aldolase Vapar_2995 ENOG4108PZW LysR family Transcriptional regulator Vapar_3001 ENOG4105D44 asparaginase Vapar_3002 ENOG4108JQ6 ABC transporter Vapar_3003 ENOG4105DEF Extracellular solute-binding protein, family 5 Vapar_3004 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Vapar_3005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_3012 ENOG4105DHQ Histidine kinase Vapar_3014 ENOG4105CSR polyphosphate kinase 2 Vapar_3018 ENOG4107QIZ NADH dehydrogenase Vapar_3019 ENOG4108JB9 formate dehydrogenase Vapar_3020 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Vapar_3022 ENOG4105D2N Aldolase Vapar_3023 ENOG4105BZA Phosphoglycerate kinase Vapar_3024 ENOG4105CV1 Transketolase (EC 2.2.1.1) Vapar_3025 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) Vapar_3026 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Vapar_3028 ENOG4105DJV ribulose-phosphate 3-epimerase Vapar_3029 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 Vapar_3030 ENOG4106F1P AAA ATPase, central domain protein Vapar_3032 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Vapar_3033 ENOG4105DUM transcriptional regulator, lysR family Vapar_3035 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_3039 ENOG4105CJ1 ABC, transporter Vapar_3040 ENOG4105DZG Dehydrogenase Vapar_3041 ENOG4105WJN methanol dehydrogenase-like protein, cytochrome cL (XoxG) Vapar_3047 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Vapar_3053 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E Vapar_3056 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) Vapar_3059 ENOG4105BZU Histidine kinase Vapar_3060 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_3065 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) Vapar_3066 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A Vapar_3073 ENOG4105I9Z UPF0264 protein Vapar_3077 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Vapar_3079 ENOG4108P4C Formaldehyde-activating enzyme Vapar_3082 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) Vapar_3084 ENOG4108M6X Dehydrogenase Vapar_3086 ENOG4105CFH Aspartokinase Vapar_3087 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Vapar_3088 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Vapar_3090 ENOG4105C8N cysteinyl-tRNA synthetase Vapar_3094 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) Vapar_3099 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Vapar_3100 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Vapar_3101 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Vapar_3108 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Vapar_3109 ENOG4108R6K riboflavin synthase, subunit alpha Vapar_3110 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Vapar_3111 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Vapar_3112 ENOG4107YIM Involved in the transcription termination process (By similarity) Vapar_3113 ENOG4105CHM Aminotransferase Vapar_3114 ENOG4107YD3 Thioesterase Vapar_3115 ENOG4105E02 MotA TolQ exbB proton channel Vapar_3116 ENOG4108ZZF transport protein (ExbD) Vapar_3118 ENOG4105C0B DNA polymerase III (alpha subunit) Vapar_3119 ENOG4105C72 UPF0176 protein Vapar_3120 ENOG4105EUB pirin domain protein Vapar_3125 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Vapar_3126 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) Vapar_3127 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Vapar_3129 ENOG4105IJJ transcriptional regulator, crp fnr family Vapar_3131 ENOG4105MP9 class II Aldolase Vapar_3133 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Vapar_3134 ENOG41079YP Citrate utilization protein b Vapar_3136 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Vapar_3141 ENOG4108IV0 ABC, transporter Vapar_3142 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_3145 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein Vapar_3146 ENOG4105BZU Histidine kinase Vapar_3147 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Vapar_3149 ENOG4105BZU Histidine kinase Vapar_3152 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions Vapar_3156 ENOG4105CD8 aminopeptidase N Vapar_3157 ENOG4105DJB Major Facilitator Superfamily Vapar_3158 ENOG4108Z9W Outer membrane porin Vapar_3165 ENOG4105C26 Dehydrogenase Vapar_3166 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) Vapar_3167 ENOG4105C7K acetolactate synthase Vapar_3168 ENOG4105CHR reductase Vapar_3169 ENOG4107HP6 Transcriptional regulator Vapar_3172 ENOG4105CHR reductase Vapar_3174 ENOG4105MWK D-amino acid dehydrogenase, small subunit Vapar_3175 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Vapar_3176 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Vapar_3192 ENOG4105C30 Nad-dependent epimerase dehydratase Vapar_3198 ENOG4106CD9 glycosyl transferase group 1 Vapar_3199 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_3204 ENOG4105C0B DNA polymerase III (alpha subunit) Vapar_3205 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA Vapar_3209 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_3210 ENOG4108Z9W Outer membrane porin Vapar_3211 ENOG4105C01 Dihydroxy-acid dehydratase Vapar_3213 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Vapar_3219 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Vapar_3221 ENOG4108KX4 response regulator Vapar_3223 ENOG4105BZ1 (ABC) transporter Vapar_3226 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Vapar_3228 ENOG4108UT2 hemolysin iii Vapar_3230 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Vapar_3232 ENOG4105MHT Transcriptional regulator, ARSR family Vapar_3234 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Vapar_3239 ENOG4105UYK outer membrane protein a Vapar_3245 ENOG4108R3E Dna-3-methyladenine glycosylase i Vapar_3248 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Vapar_3249 ENOG4105DZ2 Transcriptional regulator Vapar_3250 ENOG4105ETT transcriptional Regulator, LysR family Vapar_3253 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Vapar_3254 ENOG4105E39 Enoyl-CoA hydratase Vapar_3257 ENOG4105C26 Dehydrogenase Vapar_3260 ENOG410846T CoA-transferase family III Vapar_3266 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase Vapar_3267 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Vapar_3268 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_3270 ENOG4105EXG Transcriptional regulator Vapar_3271 ENOG4105C26 Dehydrogenase Vapar_3274 ENOG4108V1T peptidylprolyl cis-trans isomerase Vapar_3275 ENOG4105CUB amino acid Vapar_3276 ENOG4105CPD ethanolamine ammonia-lyase Vapar_3277 ENOG4107FQ9 ethanolamine ammonia-lyase Vapar_3283 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Vapar_3285 ENOG4105XJC Two component transcriptional regulator (Winged helix family Vapar_3286 ENOG4105DHQ Histidine kinase Vapar_3288 ENOG4105CHR reductase Vapar_3289 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase Vapar_3291 ENOG4107RGD Major Facilitator superfamily Vapar_3292 ENOG4105CFM UPF0317 protein Vapar_3293 ENOG4105VP0 transcriptional regulator, lysR family Vapar_3294 ENOG4105EXW epimerase dehydratase Vapar_3295 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_3297 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_3299 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Vapar_3300 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Vapar_3301 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Vapar_3305 ENOG4107QWG 2-Nitropropane dioxygenase Vapar_3307 ENOG4108PZW LysR family Transcriptional regulator Vapar_3309 ENOG4108ERU trap dicarboxylate transporter subunit DctP Vapar_3313 ENOG4105ZXK Dehydrogenase Vapar_3314 ENOG4106IUH DTW domain containing protein Vapar_3319 ENOG4105CSH Transporter Vapar_3320 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Vapar_3322 ENOG4105C2C drug resistance transporter, Bcr CflA Vapar_3324 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Vapar_3325 ENOG4107V59 shikimate Vapar_3326 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_3327 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_3328 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Vapar_3329 ENOG4105E2X shikimate dehydrogenase Vapar_3330 ENOG4107HP6 Transcriptional regulator Vapar_3332 ENOG4105XJC Two component transcriptional regulator (Winged helix family Vapar_3333 ENOG4105DHQ Histidine kinase Vapar_3337 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Vapar_3338 ENOG4105CHR reductase Vapar_3339 ENOG4105C5I Dehydrogenase Vapar_3340 ENOG4105CPQ Dehydrogenase Vapar_3341 ENOG4105DIQ Transcriptional regulator Vapar_3343 ENOG4105C2J ABC transporter Vapar_3347 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_3349 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Vapar_3352 ENOG4105C2J ABC transporter Vapar_3353 ENOG4105CNN ABC, transporter Vapar_3354 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator Vapar_3358 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Vapar_3366 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Vapar_3367 ENOG4105C4M (Ubiquinol oxidase) subunit I Vapar_3368 ENOG4108JJ8 (ABC) transporter Vapar_3369 ENOG4108JJ9 ABC, transporter Vapar_3372 ENOG4105CSU acyl-Coa dehydrogenase Vapar_3373 ENOG4105C10 Electron transfer flavoprotein Vapar_3374 ENOG4105BZJ Electron transfer flavoprotein Vapar_3375 ENOG4105EGS Mechanosensitive ion channel Vapar_3376 ENOG4105DGU Histone deacetylase Vapar_3377 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Vapar_3379 ENOG4105F8C transglutaminase domain-containing protein Vapar_3380 ENOG4105CVE Lytic murein transglycosylase Vapar_3386 ENOG4105CJ1 ABC, transporter Vapar_3393 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component Vapar_3395 ENOG4108IJ9 (ABC) transporter Vapar_3396 ENOG4108IJ9 (ABC) transporter Vapar_3397 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Vapar_3398 ENOG4105E98 transcriptional regulator DeoR family Vapar_3399 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Vapar_3401 ENOG4105DIJ Phosphoethanolamine transferase Vapar_3404 ENOG4108EC8 DNA internalization-related competence protein ComEC Vapar_3410 ENOG4105C54 Major Facilitator superfamily Vapar_3412 ENOG4108M60 Transcriptional regulator Vapar_3413 ENOG4105C5I Dehydrogenase Vapar_3414 ENOG4105D7K pfkb domain protein Vapar_3416 ENOG4105CDA abc transporter atp-binding protein Vapar_3417 ENOG4105EAB amino acid AbC transporter Vapar_3418 ENOG4105E5Q amino acid AbC transporter Vapar_3419 ENOG4105E5Q amino acid AbC transporter Vapar_3421 ENOG4105D3W isochorismatase Vapar_3425 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Vapar_3427 ENOG4105E4C Lytic transglycosylase catalytic Vapar_3428 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Vapar_3432 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Vapar_3433 ENOG4105GJM (LipO)protein Vapar_3434 ENOG4105Q2H domain protein Vapar_3437 ENOG4105EZE Cupin 4 family protein Vapar_3438 ENOG4108YZY peptidylprolyl cis-trans isomerase Vapar_3440 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Vapar_3442 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Vapar_3443 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Vapar_3444 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Vapar_3446 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Vapar_3447 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Vapar_3448 ENOG4106Z1T Nicotinamide Mononucleotide Transporter Vapar_3451 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Vapar_3452 ENOG4108Z0R Transferase Vapar_3453 ENOG4105ED9 Protein of unknown function (DUF455) Vapar_3455 ENOG4105CHU acetyl-coa acetyltransferase Vapar_3458 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Vapar_3461 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Vapar_3462 ENOG4105K8N protein family UPF0079, ATPase Vapar_3463 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Vapar_3465 ENOG4105DQR SNARE associated Golgi Vapar_3466 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Vapar_3468 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Vapar_3469 ENOG4107R39 (ABC) transporter Vapar_3472 ENOG4105EV8 ectoine hydroxylase Vapar_3474 ENOG4105GRZ Ycii-related protein Vapar_3475 ENOG4105CHP RNA polymerase Vapar_3482 ENOG4107T31 5'-nucleotidase Vapar_3484 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_3486 ENOG4108IV0 ABC, transporter Vapar_3487 ENOG4105C0Z ABC transporter Vapar_3489 ENOG4105C0R drug resistance transporter emrb qaca subfamily Vapar_3490 ENOG4105CW7 secretion protein, HlyD family Vapar_3492 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes Vapar_3493 ENOG4105BZ1 (ABC) transporter Vapar_3495 ENOG4108YZ4 nudix hydrolase Vapar_3497 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Vapar_3498 ENOG4105C8S subunit m Vapar_3500 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Vapar_3501 ENOG4105DF2 NADH dehydrogenase subunit j Vapar_3502 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Vapar_3503 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Vapar_3504 ENOG4108IEH NADH dehydrogenase subunit g Vapar_3505 ENOG4107QIZ NADH dehydrogenase Vapar_3507 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Vapar_3508 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Vapar_3509 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Vapar_3510 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Vapar_3511 ENOG4107EJC Preprotein translocase subunit SecG Vapar_3512 ENOG4105CP7 Triose-phosphate isomerase Vapar_3514 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Vapar_3515 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Vapar_3516 ENOG4105CHM Aminotransferase Vapar_3517 ENOG4105ES9 amino acid Vapar_3520 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Vapar_3522 ENOG4105I5W Transporter Vapar_3524 ENOG4105D7T ABC transporter Vapar_3528 ENOG4108IFG nitrite reductase, (NAD(P)H) Vapar_3531 ENOG4108I0Q anthranilate phosphoribosyltransferase Vapar_3532 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Vapar_3533 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_3535 ENOG4105F38 ABC transporter, permease Vapar_3536 ENOG4105EG2 ABC transporter, permease Vapar_3538 ENOG4108UY0 (LipO)protein Vapar_3539 ENOG4105CBX hi0933 family Vapar_3540 ENOG4105VCC 30S ribosomal protein S21 Vapar_3541 ENOG4105KTH gatB Yqey Vapar_3542 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Vapar_3549 ENOG4107SM8 Adenylate Guanylate cyclase Vapar_3550 ENOG4108NKV transcriptional regulator Vapar_3552 ENOG4105CMS peptidase U62, modulator of DNA gyrase Vapar_3554 ENOG4108RIR Molybdenum cofactor biosynthesis protein Vapar_3560 ENOG4105GR3 Histidine kinase Vapar_3563 ENOG4105W1Y Transcriptional regulator Vapar_3564 ENOG4105D7W serine acetyltransferase Vapar_3566 ENOG4105ECY inositol monophosphatase Vapar_3572 ENOG4105DDW LysR family Transcriptional regulator Vapar_3574 ENOG4108VHT MarR family transcriptional regulator Vapar_3576 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_3577 ENOG4105ENH Sulfatase Vapar_3579 ENOG4105BZU Histidine kinase Vapar_3582 ENOG4105CA0 peroxidase Vapar_3586 ENOG4105Q26 Siderophore-interacting protein Vapar_3587 ENOG4105D7N magnesium and cobalt transport protein CorA Vapar_3589 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Vapar_3592 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_3594 ENOG4105ENE Histidine kinase Vapar_3599 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Vapar_3601 ENOG4107RP9 extracellular solute-binding protein, family 3 Vapar_3602 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Vapar_3603 ENOG4106G6Q Transcriptional regulator Vapar_3605 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Vapar_3606 ENOG4105BZS acriflavin resistance protein Vapar_3607 ENOG4105BZS acriflavin resistance protein Vapar_3608 ENOG4105ENT Efflux transporter rnd family, mfp subunit Vapar_3612 ENOG4105C2F Histidine kinase Vapar_3613 ENOG4108VAC response regulator Vapar_3615 ENOG4105CX6 glutaminyL-tRNA synthetase Vapar_3620 ENOG4105CY0 Metallo-Beta-Lactamase Vapar_3622 ENOG4108VAC response regulator Vapar_3629 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Vapar_3631 ENOG4105C2X Arabinose 5-phosphate isomerase Vapar_3633 ENOG4105VUF Transcriptional regulator Vapar_3635 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Vapar_3637 ENOG4105D9M gamma-glutamylcysteine synthetase Vapar_3639 ENOG4106CJB Phospholipase Carboxylesterase Vapar_3648 ENOG4105CKW Inner membrane protein yedI Vapar_3651 ENOG4105VYA Uncharacterized conserved protein (DUF2132) Vapar_3654 ENOG4105D3G Pseudouridine synthase Vapar_3655 ENOG41068KF Universal stress protein Vapar_3658 ENOG4108KQ5 Integrase catalytic subunit Vapar_3659 ENOG41067HS methyltransferase Vapar_3660 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Vapar_3661 ENOG4105CEP NADH dehydrogenase Vapar_3662 ENOG4105KK6 nuclease Vapar_3663 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_3664 ENOG4108Z9K Osmotically inducible protein Vapar_3667 ENOG4107RP9 extracellular solute-binding protein, family 3 Vapar_3668 ENOG4105E5Q amino acid AbC transporter Vapar_3669 ENOG4105E5Q amino acid AbC transporter Vapar_3673 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Vapar_3676 ENOG4105MWK D-amino acid dehydrogenase, small subunit Vapar_3677 ENOG4105KXX peptidase s58 dmpa Vapar_3681 ENOG4105C5H ABC transporter Vapar_3682 ENOG4105C1J atp-dependent rna helicase Vapar_3686 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component Vapar_3688 ENOG4107EJG GntR family transcriptional regulator Vapar_3689 ENOG4105C01 Dihydroxy-acid dehydratase Vapar_3691 ENOG4108RTU Aldolase Vapar_3692 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase Vapar_3701 ENOG4108UCS ABC, transporter Vapar_3703 ENOG4108UYE Lactoylglutathione lyase Vapar_3707 ENOG4108UHU Aldolase Vapar_3708 ENOG4105C01 Dihydroxy-acid dehydratase Vapar_3712 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Vapar_3713 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Vapar_3716 ENOG4105RK9 auxin efflux carrier Vapar_3719 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Vapar_3720 ENOG4105YA8 Transcriptional regulator Vapar_3721 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Vapar_3724 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase Vapar_3725 ENOG4107QKV phosphomannomutase Vapar_3728 ENOG4107RT3 EamA-like transporter family Vapar_3732 ENOG4105CYM Glutathione S-transferase Vapar_3736 ENOG4105IBP Cyclic peptide transporter Vapar_3738 ENOG4108V3E phosphoribosylglycinamide formyltransferase Vapar_3740 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) Vapar_3741 ENOG4105E0K tonB-dependent siderophore receptor Vapar_3755 ENOG4107S4Y M20 DapE family protein YgeY Vapar_3757 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Vapar_3758 ENOG4105C28 cystathionine Vapar_3759 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Vapar_3762 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Vapar_3763 ENOG4105KUZ arsenate reductase Vapar_3765 ENOG4105NBK UPF0345 protein Vapar_3766 ENOG4105CDH Citrulline--aspartate ligase Vapar_3768 ENOG4105D4A Cell wall formation (By similarity) Vapar_3769 ENOG4108VPT UPF0234 protein Vapar_3771 ENOG4105M4H endoribonuclease L-psp Vapar_3772 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Vapar_3773 ENOG4108Z66 YbaK ebsC protein Vapar_3774 ENOG4105CPC Aldo Keto reductase Vapar_3775 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Vapar_3778 ENOG4105CS6 Rhs element vgr protein Vapar_3786 ENOG4105D01 (LipO)protein Vapar_3787 ENOG4108UMI ABC transporter, permease Vapar_3788 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Vapar_3789 ENOG4105D01 (LipO)protein Vapar_3792 ENOG4107VXZ Hydrolase Vapar_3793 ENOG4105CD8 aminopeptidase N Vapar_3795 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Vapar_3805 ENOG41067CV Integrase Vapar_3810 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit Vapar_3811 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding Vapar_3812 ENOG4105C7W Xanthine dehydrogenase Vapar_3813 ENOG4108KDI dmso reductase anchor subunit Vapar_3814 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Vapar_3815 ENOG4105DB1 molybdopterin oxidoreductase Vapar_3816 ENOG4105DUM transcriptional regulator, lysR family Vapar_3817 ENOG4105FDP GntR family transcriptional regulator Vapar_3818 ENOG4105VP7 SAF domain protein Vapar_3819 ENOG4105CTX dehydratase Vapar_3820 ENOG4108JQ1 Dehydrogenase Vapar_3821 ENOG4105DG4 malate L-lactate dehydrogenase Vapar_3824 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Vapar_3826 ENOG4108FUF Transcriptional regulator, IclR family Vapar_3831 ENOG4108EKI Dehydrogenase Vapar_3832 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_3835 ENOG4108FUF Transcriptional regulator, IclR family Vapar_3842 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Vapar_3843 ENOG4105CR8 Transcriptional regulator Vapar_3844 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Vapar_3845 ENOG4108IY8 ABC, transporter Vapar_3846 ENOG4106FTQ Taurine ABC transporter, periplasmic Vapar_3847 ENOG4108KQ5 Integrase catalytic subunit Vapar_3848 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Vapar_3856 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Vapar_3859 ENOG4105CS6 Rhs element vgr protein Vapar_3865 ENOG4105GVF (ABC) transporter Vapar_3867 ENOG4105E2Y ABC, transporter Vapar_3868 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Vapar_3869 ENOG4107Z6I Thiamine biosynthesis protein Vapar_3871 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Vapar_3873 ENOG4105FDT acyl-CoA dehydrogenase Vapar_3874 ENOG4105GVF (ABC) transporter Vapar_3875 ENOG4108T2C cysteine dioxygenase type I Vapar_3878 ENOG4105C1J atp-dependent rna helicase Vapar_3879 ENOG4105CGZ zinc metallopeptidase Vapar_3880 ENOG4105DHP deoxycytidine triphosphate deaminase Vapar_3881 ENOG4107QUY Guanine deaminase Vapar_3883 ENOG4107SQI penicillin amidase Vapar_3884 ENOG41063TF transcriptional regulator (AraC Vapar_3886 ENOG4107RDB Major Facilitator Vapar_3887 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Vapar_3888 ENOG4105W2Z cytochrome C, class I Vapar_3890 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Vapar_3895 ENOG4105GAK amidohydrolase 2 Vapar_3898 ENOG4105CI0 Citrate lyase Vapar_3899 ENOG410810E transcriptional regulator, lysR family Vapar_3902 ENOG4105UIB (ABC) transporter Vapar_3903 ENOG4108JQ9 ABC transporter Vapar_3904 ENOG4105C7N Xanthine uracil vitamin C permease Vapar_3906 ENOG4105C7W Xanthine dehydrogenase Vapar_3915 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_3919 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Vapar_3926 ENOG4107YCY Transcriptional regulator Vapar_3929 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Vapar_3932 ENOG4107RP9 extracellular solute-binding protein, family 3 Vapar_3935 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Vapar_3941 ENOG4105C2W permease Vapar_3942 ENOG4105CV8 reductase Vapar_3943 ENOG4105BZU Histidine kinase Vapar_3944 ENOG4108ZXC Two component transcriptional regulator, luxr family Vapar_3945 ENOG4105CSH Transporter Vapar_3948 ENOG4105CK2 sodium dicarboxylate symporter Vapar_3950 ENOG4105F4G Membrane Vapar_3953 ENOG4105CC0 LysR family Transcriptional regulator Vapar_3954 ENOG41060W2 glyoxylate carboligase Vapar_3955 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Vapar_3956 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Vapar_3958 ENOG4105C6K Malic enzyme Vapar_3960 ENOG4105D7T ABC transporter Vapar_3961 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Vapar_3966 ENOG4105EW9 transcriptional regulator AsnC family Vapar_3967 ENOG4105MWK D-amino acid dehydrogenase, small subunit Vapar_3969 ENOG4105D2X ABC transporter substrate-binding protein Vapar_3970 ENOG4108Z6B deaminase Vapar_3971 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Vapar_3972 ENOG4107NQ8 LysR family Transcriptional regulator Vapar_3980 ENOG4105E0K tonB-dependent siderophore receptor Vapar_3981 ENOG4105VCD cytoplasmic protein Vapar_3982 ENOG4105D22 carbon starvation protein Vapar_3984 ENOG4105K4H Nlp p60 protein Vapar_3996 ENOG4105CPC Aldo Keto reductase Vapar_3997 ENOG4105DGI Alkaline phosphatase Vapar_3998 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Vapar_3999 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Vapar_4003 ENOG4105DKT Transcriptional regulator Vapar_4005 ENOG4105EMN RNA polymerase sigma factor Vapar_4007 ENOG4105F27 Major Facilitator Vapar_4008 ENOG4108IV0 ABC, transporter Vapar_4009 ENOG4105C0Z ABC transporter Vapar_4011 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_4012 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein Vapar_4019 ENOG4105CSR polyphosphate kinase 2 Vapar_4021 ENOG4105DB7 PHP domain protein Vapar_4023 ENOG4107RTD sua5 ycio yrdc ywlc family protein Vapar_4024 ENOG4108Z4T Peptidase M50 Vapar_4025 ENOG4105C31 Tryptophanyl-tRNA synthetase Vapar_4026 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_4028 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Vapar_4030 ENOG4105C7B Threonine dehydratase Vapar_4031 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Vapar_4032 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase Vapar_4033 ENOG4105W5Q DNA repair protein (RadC Vapar_4037 ENOG4105RKW reductase (By Vapar_4038 ENOG4106PMH Extracellular solute-binding protein family 3 Vapar_4039 ENOG4105EAD ABC transporter Vapar_4040 ENOG4105DRP amino acid AbC transporter Vapar_4044 ENOG4107VXZ Hydrolase Vapar_4045 ENOG4105CSH Transporter Vapar_4046 ENOG4105E2S oxidase) subunit II Vapar_4047 ENOG4105BZ9 Cytochrome C oxidase, subunit I Vapar_4048 ENOG4105CCU oxidase (Subunit III) Vapar_4049 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) Vapar_4051 ENOG4105TX3 Histidine kinase Vapar_4052 ENOG4108UYB regulatoR Vapar_4053 ENOG4108UT2 hemolysin iii Vapar_4054 ENOG41069P5 Protein slyX homolog Vapar_4056 ENOG4105CV6 ABC transporter, permease Vapar_4057 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Vapar_4061 ENOG4105QAX Iron-sulfur Vapar_4062 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Vapar_4065 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Vapar_4068 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Vapar_4069 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Vapar_4070 ENOG4105E0C molybdate abc transporter Vapar_4071 ENOG4105F4R Transcriptional regulator mode Vapar_4072 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Vapar_4074 ENOG4105C5Q Transcriptional regulator Vapar_4077 ENOG4108YXG UPF0502 protein Vapar_4078 ENOG4108T58 Mg2 transport protein CorA Vapar_4079 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Vapar_4080 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Vapar_4081 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Vapar_4088 ENOG4105CHH sulfate transporter Vapar_4092 ENOG4108IYU L-aspartate oxidase Vapar_4093 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Vapar_4094 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Vapar_4095 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Vapar_4097 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Vapar_4098 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Vapar_4099 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Vapar_4100 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) Vapar_4102 ENOG4105WZW rhodanese family Vapar_4103 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Vapar_4104 ENOG4105CN1 protease Vapar_4105 ENOG4105D06 uba thif-type nad fad binding protein Vapar_4106 ENOG41066T0 asmA family Vapar_4108 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_4109 ENOG4105BZU Histidine kinase Vapar_4115 ENOG4105K3G Periplasmic Protein Vapar_4117 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) Vapar_4119 ENOG4105EUJ GTP cyclohydrolase i Vapar_4120 ENOG4105X23 Endonuclease Exonuclease phosphatase Vapar_4121 ENOG4108TIT dATP pyrophosphohydrolase Vapar_4122 ENOG4105C9M aspartyl-trna synthetase Vapar_4125 ENOG4105CK7 Sodium proline symporter Vapar_4126 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Vapar_4129 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Vapar_4133 ENOG4108JQ1 Dehydrogenase Vapar_4135 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Vapar_4137 ENOG4108IJ9 (ABC) transporter Vapar_4138 ENOG4107T6V glycerophosphoryl diester phosphodiesterase Vapar_4139 ENOG4105EGS Mechanosensitive ion channel Vapar_4140 ENOG4105D00 flagellar biosynthetic protein flhB Vapar_4141 ENOG4105D7B Flagellar biosynthesis protein flha Vapar_4142 ENOG4105FZW flagellar biosynthesis regulator FlhF Vapar_4144 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Vapar_4150 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) Vapar_4151 ENOG4108VYJ response regulator receiver protein Vapar_4153 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Vapar_4154 ENOG4105BZU Histidine kinase Vapar_4155 ENOG4105D58 Diguanylate phosphodiesterase Vapar_4156 ENOG4105CBS Chea signal transduction histidine kinase Vapar_4157 ENOG4105ER2 Ompa motb domain protein Vapar_4158 ENOG4107RD7 Flagellar Motor Protein, MotA Vapar_4159 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region Vapar_4164 ENOG4105MQ3 flagellar protein FliS Vapar_4165 ENOG4105DTS flagellar hook-associated Vapar_4167 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Vapar_4168 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Vapar_4169 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Vapar_4170 ENOG4108CG0 Flagellar assembly protein Vapar_4171 ENOG4108JIR Flagellum-specific ATP synthase Vapar_4172 ENOG4105GSA Flagellar export protein flij Vapar_4174 ENOG4107ZI8 flagellar basal body-associated protein flil Vapar_4175 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Vapar_4176 ENOG4105DD5 Flagellar motor switch protein Vapar_4178 ENOG4105CN7 Flagellar biosynthetic protein FliP Vapar_4179 ENOG4105VS8 Flagellar biosynthetic protein fliq Vapar_4180 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Vapar_4181 ENOG4105DTJ flagellar hook-associated protein Vapar_4182 ENOG4105E1Q flagellar hook-associated protein Vapar_4183 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_4184 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_4185 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_4186 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_4187 ENOG4108V3W Chemotaxis protein, CheW Vapar_4188 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_4189 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_4190 ENOG4108V3W Chemotaxis protein, CheW Vapar_4191 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj Vapar_4192 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Vapar_4193 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Vapar_4194 ENOG4105CGA flagellar basal-body rod protein FlgG Vapar_4195 ENOG4108KPB Flagellar basal-body rod protein FlgF Vapar_4196 ENOG4105BZE flagellar hook protein, FlgE Vapar_4197 ENOG4105W00 Flagellar hook capping protein Vapar_4198 ENOG4108ZC9 flagellar basal-body rod protein flgc Vapar_4199 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Vapar_4205 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Vapar_4206 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Vapar_4207 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Vapar_4210 ENOG4105C37 (CBS) domain Vapar_4211 ENOG4105E4C Lytic transglycosylase catalytic Vapar_4212 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Vapar_4213 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Vapar_4215 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Vapar_4216 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Vapar_4217 ENOG4105K46 50S ribosomal protein l27 Vapar_4218 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Vapar_4219 ENOG4105EAH synthase Vapar_4220 ENOG4107QHF type ii secretion system protein e Vapar_4224 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Vapar_4226 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) Vapar_4227 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) Vapar_4228 ENOG4105EXC Acyl-transferase Vapar_4229 ENOG4105M6F mutator MutT protein Vapar_4231 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Vapar_4232 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Vapar_4235 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit Vapar_4236 ENOG4105RQF LysR family Transcriptional regulator Vapar_4238 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Vapar_4239 ENOG4105BZU Histidine kinase Vapar_4240 ENOG4108YZ9 Urea amidohydrolase subunit gamma Vapar_4242 ENOG4105KI2 Urea amidohydrolase subunit beta Vapar_4243 ENOG4105CQM Urea amidohydrolase subunit alpha Vapar_4246 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Vapar_4247 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Vapar_4248 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Vapar_4252 ENOG4108Z9W Outer membrane porin Vapar_4254 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Vapar_4255 ENOG4105E3W Two component transcriptional regulator (Winged helix family Vapar_4258 ENOG4105EB3 Histidine kinase Vapar_4259 ENOG4105E3W Two component transcriptional regulator (Winged helix family Vapar_4261 ENOG41066T0 asmA family Vapar_4267 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Vapar_4274 ENOG4105DDW LysR family Transcriptional regulator Vapar_4275 ENOG4107YCY Transcriptional regulator Vapar_4280 ENOG4105DJB Major Facilitator Superfamily Vapar_4282 ENOG4105CSU acyl-Coa dehydrogenase Vapar_4294 ENOG4108UAU isochorismatase Vapar_4296 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_4298 ENOG4105C0Z ABC transporter Vapar_4299 ENOG4108IV0 ABC, transporter Vapar_4301 ENOG4105ETT transcriptional Regulator, LysR family Vapar_4303 ENOG4105CHC glucokinase (EC 2.7.1.2) Vapar_4306 ENOG4105E39 Enoyl-CoA hydratase Vapar_4307 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_4309 ENOG4105CHU acetyl-coa acetyltransferase Vapar_4312 ENOG4105CHR reductase Vapar_4313 ENOG4105R1U AraC Family Transcriptional Regulator Vapar_4316 ENOG4105DSW Fusaric acid resistance protein Vapar_4317 ENOG4105ZQC membrane protein AaeX Vapar_4318 ENOG4105Y49 secretion protein, HlyD family Vapar_4320 ENOG4105CR8 Transcriptional regulator Vapar_4321 ENOG4105BZU Histidine kinase Vapar_4323 ENOG4105CSA Coproporphyrinogen iii oxidase Vapar_4324 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Vapar_4328 ENOG4105DSJ YicC domain protein Vapar_4329 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Vapar_4330 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Vapar_4331 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Vapar_4332 ENOG4108RRZ Transcription elongation factor GreB Vapar_4334 ENOG4108EJ0 Catalyzes the synthesis of activated sulfate (By similarity) Vapar_4335 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Vapar_4336 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Vapar_4337 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Vapar_4338 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Vapar_4339 ENOG4105CEN a g-specific adenine glycosylase Vapar_4340 ENOG410890F Dynamin family Vapar_4341 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Vapar_4344 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Vapar_4345 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Vapar_4346 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Vapar_4347 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Vapar_4349 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding Vapar_4351 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_4353 ENOG4108JQ7 (ABC) transporter Vapar_4354 ENOG4105DEF Extracellular solute-binding protein, family 5 Vapar_4356 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_4358 ENOG4105F04 LysR family Transcriptional regulator Vapar_4363 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Vapar_4364 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Vapar_4365 ENOG4105E7W lamb ycsf family protein Vapar_4366 ENOG4107R7A Allophanate hydrolase subunit 2 Vapar_4367 ENOG4105P4J Allophanate hydrolase, subunit 1 Vapar_4368 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Vapar_4369 ENOG4106H78 methyltransferase Vapar_4377 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_4379 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Vapar_4380 ENOG4105F1N DNA alkylation repair Vapar_4382 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Vapar_4387 ENOG4107QS1 Cytochrome C Oxidase, Subunit III Vapar_4389 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) Vapar_4391 ENOG4105BZ9 Cytochrome C oxidase, subunit I Vapar_4392 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Vapar_4394 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Vapar_4395 ENOG4105MJ2 Competence protein Vapar_4396 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Vapar_4398 ENOG4105D1F ATP-binding protein Vapar_4399 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein Vapar_4402 ENOG4105E9F Enoyl-CoA hydratase Vapar_4403 ENOG4105E4E Thioester reductase domain-containing protein Vapar_4405 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_4406 ENOG4105CSU acyl-Coa dehydrogenase Vapar_4410 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase Vapar_4414 ENOG4105KCV RNA signal recognition particle 4.5S RNA Vapar_4418 ENOG4108T5G Adenylate Vapar_4419 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP Vapar_4421 ENOG4105E0Y RtcB Protein Vapar_4422 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Vapar_4423 ENOG4105CYB regulatoR Vapar_4424 ENOG4105CIF Ornithine Cyclodeaminase Vapar_4427 ENOG4105E0F Histidine kinase Vapar_4428 ENOG4108ZHJ Organic hydroperoxide resistance protein Vapar_4429 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Vapar_4431 ENOG4108Z4X TRANSCRIPTIONal Vapar_4433 ENOG4105CHU acetyl-coa acetyltransferase Vapar_4434 ENOG4107QNJ CoA-transferase subunit B Vapar_4436 ENOG4107HP6 Transcriptional regulator Vapar_4439 ENOG4108Q9V regulatoR Vapar_4440 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) Vapar_4454 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Vapar_4457 ENOG4108JJA ABC, transporter Vapar_4460 ENOG4105KCK Peptidoglycan-associated lipoprotein Vapar_4463 ENOG4105DDW LysR family Transcriptional regulator Vapar_4466 ENOG4106RE7 Cytochrome Vapar_4467 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Vapar_4475 ENOG4105FCD Major Facilitator Vapar_4477 ENOG4105DUM transcriptional regulator, lysR family Vapar_4478 ENOG4105CA9 Pyruvate kinase Vapar_4479 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Vapar_4481 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Vapar_4482 ENOG4105CMV Succinyl-CoA synthetase subunit beta Vapar_4484 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_4485 ENOG4105BZU Histidine kinase Vapar_4487 ENOG4105CFN oxalyl-CoA decarboxylase Vapar_4522 ENOG4105D5K Hemolysin activator protein Vapar_4525 ENOG4105CKT filamentous hemagglutinin Vapar_4536 ENOG4105C0B DNA polymerase III (alpha subunit) Vapar_4537 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA Vapar_4565 ENOG4107YU2 histidine triad (hIT) protein Vapar_4567 ENOG4107QYX exodeoxyribonuclease v alpha Vapar_4568 ENOG4107QKA exodeoxyribonuclease V beta Vapar_4569 ENOG4105DSY exodeoxyribonuclease V, gamma Vapar_4572 ENOG4106BRA Membrane Vapar_4577 ENOG4108UVJ appr-1-p processing domain protein Vapar_4580 ENOG4107VRP DNA repair exonuclease Vapar_4585 ENOG4105C0D helicase Vapar_4600 ENOG4107QZV Type I secretion membrane fusion protein Vapar_4601 ENOG4108JJA ABC, transporter Vapar_4605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Vapar_4606 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Vapar_4607 ENOG4105C08 Histidine kinase Vapar_4609 ENOG4108K01 transcriptional regulator Vapar_4613 ENOG4105CD3 dihydroorotase Vapar_4614 ENOG4105CXT aspartate transcarbamylase Vapar_4615 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Vapar_4616 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Vapar_4617 ENOG4108UJU UPF0301 protein Vapar_4618 ENOG4105CVP deoxyribo-dipyrimidine photolyase Vapar_4622 ENOG4105CBS Chea signal transduction histidine kinase Vapar_4623 ENOG4105C8Q Methyl-accepting chemotaxis Vapar_4625 ENOG4105M3Z response regulator Vapar_4626 ENOG4108UNF response regulator Vapar_4627 ENOG4105VCQ rubredoxin Vapar_4629 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Vapar_4630 ENOG4105DC1 bifunctional purine biosynthesis protein purh Vapar_4632 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Vapar_4633 ENOG4105W39 Membrane Vapar_4635 ENOG4105C3G gtp-binding protein Vapar_4636 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Vapar_4637 ENOG4105C2J ABC transporter Vapar_4638 ENOG4105CNN ABC, transporter Vapar_4639 ENOG4105ETE Transcriptional regulator (LacI family Vapar_4640 ENOG4108RVA ribokinase Vapar_4641 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Vapar_4643 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family Vapar_4644 ENOG4105T95 Thiol disulfide interChange protein Vapar_4646 ENOG4105E39 Enoyl-CoA hydratase Vapar_4650 ENOG4105CF1 Alkylated DNA repair protein Vapar_4651 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Vapar_4656 ENOG4105PGM cation diffusion facilitator family transporter Vapar_4657 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Vapar_4658 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase Vapar_4659 ENOG4105E8V Alpha Beta Hydrolase Fold protein Vapar_4660 ENOG41077RS Phosphatase Vapar_4663 ENOG4108HPI phosphatidate Cytidylyltransferase Vapar_4665 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Vapar_4666 ENOG4105C9A Phoh family Vapar_4667 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Vapar_4668 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Vapar_4672 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Vapar_4673 ENOG4105DR5 peptidase Vapar_4674 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Vapar_4675 ENOG4105C0R drug resistance transporter emrb qaca subfamily Vapar_4676 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Vapar_4677 ENOG4108UJD 30S ribosomal protein S9 Vapar_4678 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Vapar_4679 ENOG4105D6S protein involved in catabolism of external DNA Vapar_4681 ENOG4105SYT Methylenetetrahydrofolate reductase Vapar_4683 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Vapar_4686 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Vapar_4691 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_4692 ENOG41067B5 Histone deacetylase superfamily protein Vapar_4693 ENOG4107QWB Ornithine cyclodeaminase Vapar_4695 ENOG4108JPW Aminotransferase Vapar_4696 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_4698 ENOG4105F38 ABC transporter, permease Vapar_4699 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component Vapar_4700 ENOG4105CYW agmatinase Vapar_4701 ENOG4105C26 Dehydrogenase Vapar_4702 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Vapar_4706 ENOG4105CSH Transporter Vapar_4710 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Vapar_4711 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Vapar_4713 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_4716 ENOG4108K8U Glycerol operon regulatory protein Vapar_4717 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Vapar_4721 ENOG41060WC Enoyl-CoA hydratase Vapar_4722 ENOG4107QX3 carboxylase Vapar_4723 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_4724 ENOG4105C1G acyl-Coa dehydrogenase Vapar_4727 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 Vapar_4728 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Vapar_4729 ENOG4105K5B UPF0225 protein Vapar_4730 ENOG4105C1G acyl-Coa dehydrogenase Vapar_4732 ENOG4105CHU acetyl-coa acetyltransferase Vapar_4733 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) Vapar_4734 ENOG41077A9 carbonic anhydrase Vapar_4735 ENOG4108Z6Z Transcriptional regulator Vapar_4738 ENOG4105D3G Pseudouridine synthase Vapar_4739 ENOG4105CHR reductase Vapar_4742 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Vapar_4743 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Vapar_4744 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit Vapar_4745 ENOG4105CBD Diacylglycerol kinase Vapar_4746 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Vapar_4747 ENOG410841Q phosphoesterase PA-phosphatase related protein Vapar_4752 ENOG4105HEI LysR family (Transcriptional regulator Vapar_4753 ENOG4105EQ0 Major Facilitator superfamily Vapar_4760 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component Vapar_4762 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Vapar_4763 ENOG4108JU5 Magnesium and cobalt efflux protein Vapar_4765 ENOG4108XM1 transcriptional regulator AsnC family Vapar_4767 ENOG4105F87 Dehydratase Vapar_4768 ENOG4105MIR Phenylalanine 4-monooxygenase Vapar_4769 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_4771 ENOG4105C5H ABC transporter Vapar_4772 ENOG4107RZC phospholipase d Vapar_4781 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase Vapar_4788 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Vapar_4792 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Vapar_4793 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_4796 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Vapar_4798 ENOG4105U5Y Transcriptional regulator Vapar_4803 ENOG4105CYW agmatinase Vapar_4808 ENOG4105D82 Glutamate dehydrogenase Vapar_4810 ENOG4105C26 Dehydrogenase Vapar_4811 ENOG4105EW9 transcriptional regulator AsnC family Vapar_4812 ENOG4105DFA alanine racemase domain protein Vapar_4813 ENOG4105CZX twitching motility protein Vapar_4814 ENOG4105CZX twitching motility protein Vapar_4815 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Vapar_4817 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Vapar_4818 ENOG41082RQ UPF0102 protein Vapar_4819 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Vapar_4824 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Vapar_4826 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Vapar_4831 ENOG4105C1P efflux transporter, rnd family, mfp subunit Vapar_4832 ENOG4105BZS acriflavin resistance protein Vapar_4833 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Vapar_4836 ENOG4105DNZ Alpha Beta Hydrolase Vapar_4838 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) Vapar_4839 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Vapar_4840 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) Vapar_4841 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Vapar_4842 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) Vapar_4843 ENOG4108VQN 4-hydroxyphenylacetate 3-monooxygenase reductase Vapar_4844 ENOG4108R86 Transcriptional regulator Vapar_4857 ENOG4105K63 Thioredoxin Vapar_4858 ENOG4107QRT dEAD DEAH box helicase Vapar_4859 ENOG4107T0X DNA ligase Vapar_4860 ENOG4107T0X DNA ligase Vapar_4863 ENOG4105CIB oxidoreductase Domain protein Vapar_4864 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Vapar_4865 ENOG4105CNN ABC, transporter Vapar_4868 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Vapar_4869 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Vapar_4871 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Vapar_4872 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Vapar_4873 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Vapar_4874 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Vapar_4875 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Vapar_4876 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) Vapar_4878 ENOG4105F0I Aminotransferase Vapar_4879 ENOG4108Z43 UPF0250 protein Vapar_4880 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Vapar_4881 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Vapar_4884 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_4885 ENOG4105F4P )-transporter Vapar_4889 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Vapar_4890 ENOG410804D Sensor Signal Transduction Histidine Kinase Vapar_4891 ENOG4105E3W Two component transcriptional regulator (Winged helix family Vapar_4896 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Vapar_4897 ENOG41080Z8 PHOSPHOCARRIER protein Vapar_4899 ENOG4105C2C drug resistance transporter, Bcr CflA Vapar_4901 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Vapar_4902 ENOG4105KY5 gCN5-related N-acetyltransferase Vapar_4904 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Vapar_4905 ENOG41084PQ 50s ribosomal protein l29 Vapar_4906 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Vapar_4907 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Vapar_4908 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Vapar_4909 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Vapar_4910 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Vapar_4911 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Vapar_4912 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Vapar_4913 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Vapar_4916 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Vapar_4917 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Vapar_4918 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Vapar_4919 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Vapar_4920 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Vapar_4921 ENOG4105DZ1 carboxypeptidase Vapar_4922 ENOG4105DHZ alpha beta Vapar_4925 ENOG4108YXA Membrane Vapar_4926 ENOG4105D52 delta-aminolevulinic acid dehydratase Vapar_4927 ENOG4105D7N magnesium and cobalt transport protein CorA Vapar_4929 ENOG4105CR8 Transcriptional regulator Vapar_4932 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Vapar_4933 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Vapar_4937 ENOG4108IV0 ABC, transporter Vapar_4938 ENOG4105C0Z ABC transporter Vapar_4940 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_4943 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Vapar_4944 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Vapar_4947 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Vapar_4948 ENOG4109066 lysm domain bon superfamily protein Vapar_4950 ENOG4105CH5 extracellular solute-binding protein, family 7 Vapar_4952 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_4953 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Vapar_4955 ENOG4105DC8 reductase Vapar_4956 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Vapar_4957 ENOG4105FYV Amp nucleosidase Vapar_4959 ENOG4108ZHR arsR family transcriptional regulator Vapar_4963 ENOG4105HEI LysR family (Transcriptional regulator Vapar_4964 ENOG4105CJ1 ABC, transporter Vapar_4966 ENOG4105K56 Transcriptional regulator Vapar_4967 ENOG4108ZHJ Organic hydroperoxide resistance protein Vapar_4969 ENOG4105E27 serine threonine protein kinase Vapar_4970 ENOG4107RSM transcriptional regulator Vapar_4971 ENOG4105CSU acyl-Coa dehydrogenase Vapar_4973 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_4976 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Vapar_4977 ENOG4105C4Y ABC transporter Vapar_4978 ENOG4105CC0 LysR family Transcriptional regulator Vapar_4980 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Vapar_4982 ENOG4105DHQ Histidine kinase Vapar_4983 ENOG4105XJC Two component transcriptional regulator (Winged helix family Vapar_4985 ENOG4105FE9 pseudouridine synthase Vapar_4986 ENOG4108QBV Monogalactosyldiacylglycerol synthase Vapar_4990 ENOG4105EEX Two component transcriptional regulator (Winged helix family Vapar_4991 ENOG4105C08 Histidine kinase Vapar_4993 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Vapar_4994 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Vapar_4995 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Vapar_4998 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Vapar_5001 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Vapar_5003 ENOG410904N short-chain dehydrogenase reductase Vapar_5005 ENOG4105IJJ transcriptional regulator, crp fnr family Vapar_5006 ENOG4108IQE Amp-dependent synthetase and ligase Vapar_5007 ENOG4105C0Z ABC transporter Vapar_5011 ENOG4108IV0 ABC, transporter Vapar_5013 ENOG4107R7Y intracellular protease Pfpi family Vapar_5018 ENOG4105DZG Dehydrogenase Vapar_5020 ENOG4105DZG Dehydrogenase Vapar_5021 ENOG4105E2R ROK family Vapar_5022 ENOG4105C2J ABC transporter Vapar_5023 ENOG4108HWW ABC transporter Vapar_5024 ENOG4105DFW ABC transporter Vapar_5026 ENOG4107RP9 extracellular solute-binding protein, family 3 Vapar_5027 ENOG4108M0I Transcriptional regulator Vapar_5030 ENOG4107RUY (E1 component), alpha subunit Vapar_5031 ENOG4105CPP Dehydrogenase, E1 component Vapar_5033 ENOG4105F6U Short-chain dehydrogenase reductase Sdr Vapar_5034 ENOG4105EJC lysr family transcriptional regulator Vapar_5037 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Vapar_5040 ENOG4108UKI Enoyl-CoA hydratase Vapar_5041 ENOG4105C1G acyl-Coa dehydrogenase Vapar_5044 ENOG4108ZT0 50S ribosomal protein l17 Vapar_5045 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Vapar_5046 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Vapar_5047 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Vapar_5048 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Vapar_5049 ENOG41067V7 50S ribosomal protein L36 Vapar_5050 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Vapar_5051 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Vapar_5052 ENOG4105VPB 50S ribosomal protein L30 Vapar_5053 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Vapar_5054 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Vapar_5055 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Vapar_5056 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Vapar_5057 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Vapar_5058 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Vapar_5059 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Vapar_5060 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Vapar_5062 ENOG4105II7 pyrroline-5-carboxylate reductase Vapar_5064 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) Vapar_5068 ENOG4105CB5 ATP-dependent DNA helicase recG Vapar_5069 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Vapar_5071 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Vapar_5082 ENOG4105SKN orotidine 5''-phosphate decarboxylase Vapar_5085 ENOG41072GX Peptidase M22 Glycoprotease Vapar_5087 ENOG4105E98 transcriptional regulator DeoR family Vapar_5088 ENOG4107VIJ nudix hydrolase Vapar_5089 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family Vapar_5091 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Vapar_5092 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Vapar_5093 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Vapar_5096 ENOG4105C8V SAICAR synthetase Vapar_5098 ENOG4108ZRZ Transcriptional regulator (AsnC family) Vapar_5099 ENOG4105K6H D-cysteine desulfhydrase Vapar_5100 ENOG4105CA9 Pyruvate kinase Vapar_5101 ENOG4105BZA Phosphoglycerate kinase Vapar_5102 ENOG4105DUM transcriptional regulator, lysR family Vapar_5105 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase Vapar_5111 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Vapar_5115 ENOG4105C79 DNA protecting protein DprA Vapar_5116 ENOG4108RPN Protein smg homolog Vapar_5118 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Vapar_5119 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Vapar_5120 ENOG4105VIE preprotein translocase, subunit YajC Vapar_5122 ENOG4105F7P transcriptional regulator AsnC family Vapar_5123 ENOG4106PMH Extracellular solute-binding protein family 3 Vapar_5124 ENOG4105DRP amino acid AbC transporter Vapar_5125 ENOG4107SFI Major Facilitator superfamily Vapar_5127 ENOG4107QS1 Cytochrome C Oxidase, Subunit III Vapar_5129 ENOG4105BZ9 Cytochrome C oxidase, subunit I Vapar_5130 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Vapar_5134 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component Vapar_5140 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) Vapar_5142 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Vapar_5143 ENOG4105FB2 class II Aldolase Vapar_5144 ENOG4105G63 Type III effector Hrp-dependent Vapar_5145 ENOG4105EXW epimerase dehydratase Vapar_5146 ENOG4105ZXK Dehydrogenase Vapar_5147 ENOG4105CSP Major Facilitator Superfamily Vapar_5148 ENOG4105JXH GntR family transcriptional regulator Vapar_5149 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Vapar_5150 ENOG4108YXU transcriptional regulator AsnC family Vapar_5156 ENOG4108ZXC Two component transcriptional regulator, luxr family Vapar_5157 ENOG4105BZU Histidine kinase Vapar_5160 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Vapar_5161 ENOG4105K6T rare lipoprotein A Vapar_5162 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Vapar_5163 ENOG4108KPJ rna polymerase sigma factor Vapar_5166 ENOG4108U78 Glutathione S-transferase Vapar_5167 ENOG4107QTF adenylosuccinate lyase Vapar_5169 ENOG4105GAV receptor Vapar_5170 ENOG4108VWS Yaeq family Vapar_5173 ENOG4108ZCF integral membrane protein Vapar_5175 ENOG41086DT Membrane protein of unknown function Vapar_5176 ENOG4105ERG peptidase m48, ste24p Vapar_5177 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Vapar_5185 ENOG4105KHS type IV fimbrial pilin protein Vapar_5187 ENOG4105F8J Adenylate Guanylate cyclase Vapar_5189 ENOG4108ZF3 Phosphatase Vapar_5190 ENOG4108ZCF integral membrane protein Vapar_5191 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Vapar_5192 ENOG4105CMV Succinyl-CoA synthetase subunit beta Vapar_5193 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Vapar_5194 ENOG4108004 Modulates RecA activity (By similarity) Vapar_5195 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Vapar_5198 ENOG4105DHQ Histidine kinase Vapar_5200 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Vapar_5202 ENOG4105C9U ATP-dependent DNA helicase RecQ Vapar_5204 ENOG4105ETT transcriptional Regulator, LysR family Vapar_5211 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Vapar_5212 ENOG4105C1J atp-dependent rna helicase Vapar_5216 ENOG4108WYP Transcriptional regulator Vapar_5219 ENOG4105MWK D-amino acid dehydrogenase, small subunit Vapar_5220 ENOG4105CTU Proline racemase Vapar_5221 ENOG4105CP9 extracellular ligand-binding receptor Vapar_5222 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Vapar_5224 ENOG4105CH2 amidohydrolase Vapar_5228 ENOG4105DRR Transcriptional regulator, GntR family Vapar_5231 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Vapar_5232 ENOG4108JQ6 ABC transporter Vapar_5233 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_5235 ENOG4105DEF Extracellular solute-binding protein, family 5 Vapar_5236 ENOG4105MP9 class II Aldolase Vapar_5237 ENOG4105EUB pirin domain protein Vapar_5242 ENOG4105E5Q amino acid AbC transporter Vapar_5243 ENOG4105F87 Dehydratase Vapar_5244 ENOG4105CM2 brancheD-chain amino acid aminotransferase Vapar_5245 ENOG4108JEH abc transporter atp-binding protein Vapar_5246 ENOG4108YZY peptidylprolyl cis-trans isomerase Vapar_5250 ENOG4105EUB pirin domain protein Vapar_5252 ENOG4105D4Y metalloprotease Vapar_5255 ENOG4105VRH Antibiotic biosynthesis monooxygenase Vapar_5258 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Vapar_5259 ENOG4105CV1 Transketolase (EC 2.2.1.1) Vapar_5260 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Vapar_5261 ENOG4108S0S Nucleotidyl transferase Vapar_5262 ENOG4107RAQ aminopeptidase Vapar_5263 ENOG410642W LysR family Transcriptional regulator Vapar_5270 ENOG4105C6K Malic enzyme Vapar_5273 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Vapar_5274 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Vapar_5275 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Vapar_5276 ENOG4105EHM Aminoglycoside phosphotransferase Vapar_5277 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Vapar_5280 ENOG4105DXI Major Facilitator superfamily Vapar_5281 ENOG4105E5G Alpha beta hydrolase fold Vapar_5285 ENOG4105EYW Ion transport protein Vapar_5286 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Vapar_5287 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Vapar_5288 ENOG4105DWV Homoserine O-trans-acetylase Vapar_5290 ENOG4105VFU Rna-binding protein Vapar_5291 ENOG4105EMU Dehydrogenase Vapar_5293 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Vapar_5294 ENOG4105C2X Arabinose 5-phosphate isomerase Vapar_5297 ENOG4105CSV Glutaminase Vapar_5298 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Vapar_5299 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Vapar_5300 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Vapar_5301 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Vapar_5306 ENOG4108KC1 acyl-Coa dehydrogenase Vapar_5312 ENOG4105D2S major facilitator superfamily Vapar_5319 ENOG4105CNN ABC, transporter Vapar_5321 ENOG4105DIA mandelate racemase muconate lactonizing Vapar_5322 ENOG4105CHR reductase Vapar_5323 ENOG4105QJH Domain of unknown function (DUF718) Vapar_5326 ENOG4105CHR reductase Vapar_5329 ENOG4105CXK mandelate racemase muconate lactonizing Vapar_5330 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_5331 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Vapar_5332 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_5333 ENOG4105CPQ Dehydrogenase Vapar_5334 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Vapar_5335 ENOG4107QSN dihydrolipoamide acetyltransferase Vapar_5336 ENOG4107QN2 dihydrolipoyl dehydrogenase Vapar_5337 ENOG4105EV9 Alpha Beta Hydrolase Vapar_5338 ENOG4105C6K Malic enzyme Vapar_5340 ENOG4105CEP NADH dehydrogenase Vapar_5341 ENOG4105CHU acetyl-coa acetyltransferase Vapar_5342 ENOG4105CHR reductase Vapar_5344 ENOG4105CQZ Histidine kinase Vapar_5345 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Vapar_5351 ENOG4108NH8 Cation transport protein Vapar_5352 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_5354 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase Vapar_5355 ENOG4105EA8 2-Nitropropane dioxygenase Vapar_5356 ENOG4105CSU acyl-Coa dehydrogenase Vapar_5357 ENOG4105CHU acetyl-coa acetyltransferase Vapar_5358 ENOG4108IG5 Transcriptional regulator Vapar_5360 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Vapar_5364 ENOG4105E1F short-chain dehydrogenase reductase Vapar_5365 ENOG4105HEI LysR family (Transcriptional regulator Vapar_5366 ENOG4105XMH SpoVT AbrB domain protein Vapar_5367 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Vapar_5370 ENOG4105R5N Phosphoribosyl-dephospho-CoA transferase Vapar_5377 ENOG4108K70 Transcriptional regulator Vapar_5385 ENOG4108R85 Short chain dehydrogenase Vapar_5387 ENOG41061H0 Monooxygenase Vapar_5388 ENOG4105F04 LysR family Transcriptional regulator Vapar_5395 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Vapar_5396 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Vapar_5403 ENOG4108ZXC Two component transcriptional regulator, luxr family Vapar_5404 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_5409 ENOG4105EQ2 LysR family Transcriptional regulator Vapar_5415 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_5416 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) Vapar_5419 ENOG4105CS1 NAD(P)H quinone oxidoreductase Vapar_5420 ENOG4105CC0 LysR family Transcriptional regulator Vapar_5424 ENOG41061N2 exported protein Vapar_5425 ENOG4105R1U AraC Family Transcriptional Regulator Vapar_5426 ENOG4105DJ2 Major Facilitator Superfamily Vapar_5427 ENOG4108K3A Glutathione S-transferase Vapar_5431 ENOG4108K3A Glutathione S-transferase Vapar_5435 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Vapar_5439 ENOG4105CH6 catalase Vapar_5440 ENOG4105HEI LysR family (Transcriptional regulator Vapar_5441 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr Vapar_5442 ENOG4105EXC Acyl-transferase Vapar_5445 ENOG4105CPT Alpha beta hydrolase Vapar_5449 ENOG4105BZU Histidine kinase Vapar_5454 ENOG4105RQF LysR family Transcriptional regulator Vapar_5455 ENOG4105DIA mandelate racemase muconate lactonizing Vapar_5456 ENOG4107Y2X deaminase Vapar_5458 ENOG4105VT2 5-hydroxyisourate hydrolase Vapar_5459 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) Vapar_5470 ENOG4105EFZ amidohydrolase Vapar_5472 ENOG4105CHJ isochorismatase hydrolase Vapar_5474 ENOG4105EQ1 Transcriptional regulator Vapar_5478 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Vapar_5488 ENOG4105C7W Xanthine dehydrogenase Vapar_5489 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding Vapar_5490 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit Vapar_5491 ENOG4105CF7 AraC family transcriptional regulator Vapar_5497 ENOG4105CD5 CoA-binding domain protein Vapar_5498 ENOG4106YT9 Enoyl-CoA hydratase Vapar_5500 ENOG4105CC9 acyl-Coa dehydrogenase Vapar_5503 ENOG4105HEI LysR family (Transcriptional regulator Vapar_5507 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_5512 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_5513 ENOG4105CXT aspartate transcarbamylase Vapar_5518 ENOG4105FDP GntR family transcriptional regulator Vapar_5519 ENOG4105DIA mandelate racemase muconate lactonizing Vapar_5523 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Vapar_5528 ENOG4105CG3 alpha amylase, catalytic region Vapar_5532 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Vapar_5534 ENOG4105CXK mandelate racemase muconate lactonizing Vapar_5537 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_5539 ENOG41073TP transcriptional regulator Vapar_5541 ENOG4106HBX Transcriptional Regulator AraC Family Vapar_5542 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Vapar_5544 ENOG4105CHR reductase Vapar_5545 ENOG4105DAA L-lactate Vapar_5548 ENOG4105C7K acetolactate synthase Vapar_5551 ENOG4105EMU Dehydrogenase Vapar_5552 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Vapar_5556 ENOG4105WH1 Two component transcriptional regulator luxr family Vapar_5557 ENOG4105FCD Major Facilitator Vapar_5560 ENOG4105EUR Domain-Containing protein Vapar_5565 ENOG4105EA8 2-Nitropropane dioxygenase Vapar_5567 ENOG41080HT Transcriptional regulator, arsr family Vapar_5568 ENOG4105MD1 YeeE YedE family protein Vapar_5571 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Vapar_5573 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Vapar_5575 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Vapar_5576 ENOG4105DBV ornithine carbamoyltransferase Vapar_5577 ENOG41068KF Universal stress protein Vapar_5579 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Vapar_5580 ENOG4105BZU Histidine kinase Vapar_5583 ENOG4105DUM transcriptional regulator, lysR family Vapar_5585 ENOG4105JSC dimethylmenaquinone methyltransferase Vapar_5586 ENOG4108JQ1 Dehydrogenase Vapar_5588 ENOG4105C7K acetolactate synthase Vapar_5589 ENOG4105MWK D-amino acid dehydrogenase, small subunit Vapar_5591 ENOG4105E5Q amino acid AbC transporter Vapar_5592 ENOG4105CDA abc transporter atp-binding protein Vapar_5594 ENOG4108UYU AsnC family transcriptional regulator Vapar_5597 ENOG4108UQ8 endoribonuclease L-psp Vapar_5598 ENOG4108KWP DNA-binding transcriptional regulator GlcC Vapar_5599 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Vapar_5602 ENOG4105E5Q amino acid AbC transporter Vapar_5604 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Vapar_5606 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Vapar_5607 ENOG4105CDA abc transporter atp-binding protein Vapar_5611 ENOG4108MP6 LysR family Transcriptional regulator Vapar_5622 ENOG4107RSM transcriptional regulator Vapar_5623 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Vapar_5625 ENOG4105C0R drug resistance transporter emrb qaca subfamily Vapar_5628 ENOG4108RYR transcriptional regulator AsnC family Vapar_5630 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Vapar_5633 ENOG4105CJP fad dependent oxidoreductase Vapar_5634 ENOG4108J59 Extracellular solute-binding protein, family 5 Vapar_5636 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_5638 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Vapar_5639 ENOG4105C26 Dehydrogenase Vapar_5640 ENOG4108Z6Z Transcriptional regulator Vapar_5650 ENOG4105DND Transcriptional regulator Vapar_5667 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Vapar_5671 ENOG4105CHR reductase Vapar_5674 ENOG4107RSM transcriptional regulator Vapar_5675 ENOG4107YNJ LysR family Transcriptional regulator Vapar_5676 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase Vapar_5678 ENOG4105CHR reductase Vapar_5679 ENOG4105CMJ mandelate racemase muconate lactonizing Vapar_5680 ENOG4105CS6 Rhs element vgr protein Vapar_5681 ENOG4105CNA YD repeat protein Vapar_5690 ENOG4105C26 Dehydrogenase Vapar_5691 ENOG4105BZU Histidine kinase Vapar_5692 ENOG4105D2S major facilitator superfamily Vapar_5700 ENOG4105E2X shikimate dehydrogenase Vapar_5704 ENOG41073TP transcriptional regulator Vapar_5710 ENOG4105JSC dimethylmenaquinone methyltransferase Vapar_5717 ENOG4105ERH Fumarylacetoacetate hydrolase Vapar_5720 ENOG4108YYH Nadph-dependent fmn reductase Vapar_5721 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_5722 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Vapar_5723 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_5729 ENOG4105EE5 Membrane protein terC Vapar_5738 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase Vapar_5743 ENOG4105KHM amidohydrolase 2 Vapar_5744 ENOG4107F9Y LysR family transcriptional regulator Vapar_5745 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Vapar_5747 ENOG4105EQ2 LysR family Transcriptional regulator Vapar_5752 ENOG4105C5I Dehydrogenase Vapar_5754 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Vapar_5762 ENOG4108K01 transcriptional regulator Vapar_5763 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_5766 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Vapar_5769 ENOG410900P UPF0336 protein Vapar_5773 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_5774 ENOG4108UKI Enoyl-CoA hydratase Vapar_5776 ENOG4105CHU acetyl-coa acetyltransferase Vapar_5789 ENOG4105EWI Short-chain dehydrogenase reductase Sdr Vapar_5792 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_5794 ENOG4105EM2 membrane Vapar_5800 ENOG4105CHM Aminotransferase Vapar_5802 ENOG4105JSC dimethylmenaquinone methyltransferase Vapar_5805 ENOG4108XM1 transcriptional regulator AsnC family Vapar_5811 ENOG4105FA0 parb-like partition protein Vapar_5822 ENOG4108EHY type IV secretion system Vapar_5841 ENOG4105E2V Glycosyltransferase 36 Vapar_5846 ENOG4105CDA abc transporter atp-binding protein Vapar_5849 ENOG4105F5W AtP-binding protein Vapar_5850 ENOG4105D70 Integrase catalytic subunit Vapar_5854 ENOG4105ESI atpase involved in dna repair Vapar_5866 ENOG4105C5Q Transcriptional regulator Vapar_5871 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_5873 ENOG4105CHU acetyl-coa acetyltransferase Vapar_5874 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Vapar_5876 ENOG4105E39 Enoyl-CoA hydratase Vapar_5886 ENOG4105C26 Dehydrogenase Vapar_5888 ENOG4105E9Z Nad-dependent epimerase dehydratase Vapar_5889 ENOG4105DTQ mandelate racemase muconate lactonizing Vapar_5890 ENOG4108Z9W Outer membrane porin Vapar_5897 ENOG4105W2Z cytochrome C, class I Vapar_5917 ENOG4105CAF HipA N-terminal domain protein Vapar_5927 ENOG4108Z9W Outer membrane porin Vapar_5936 ENOG4105CAF HipA N-terminal domain protein Vapar_5938 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Vapar_5948 ENOG4108JQ6 ABC transporter Vapar_5958 ENOG4108JJ6 Type I secretion system ATPase Vapar_5961 ENOG4108Z9W Outer membrane porin Vapar_5963 ENOG4105CKI cobalamin synthesis protein Vapar_5967 ENOG4105ERH Fumarylacetoacetate hydrolase Vapar_5968 ENOG41063Z6 transcriptional regulator, lysR family Vapar_5972 ENOG4108IV0 ABC, transporter Vapar_5973 ENOG4105C0Z ABC transporter Vapar_5974 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Vapar_5975 ENOG4105C32 Amino acid ABC transporter (Permease) Vapar_5976 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_6002 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Vapar_6008 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Vapar_6013 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Vapar_6015 ENOG4105CQ2 DNA polymerase Vapar_6017 ENOG4105BZU Histidine kinase Vapar_6025 ENOG41082A2 Alpha beta hydrolase Vapar_6028 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Vapar_6031 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 Vapar_6032 ENOG4105CXK mandelate racemase muconate lactonizing Vapar_6033 ENOG4107TUS Dihydrodipicolinate synthase Vapar_6037 ENOG4107S5I aldo keto reductase Vapar_6038 ENOG4105EQ2 LysR family Transcriptional regulator Vapar_6042 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Vapar_6043 ENOG4105W8H transhydrogenase (subunit alpha Vapar_6044 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Vapar_6045 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Vapar_6046 ENOG41084KP 4-oxalocrotonate tautomerase Vapar_6052 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Vapar_6054 ENOG4108WYP Transcriptional regulator Vapar_6056 ENOG4105CKI cobalamin synthesis protein Vapar_6058 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Vapar_6060 ENOG4105DTQ mandelate racemase muconate lactonizing Vapar_6063 ENOG4105CI2 imidazolone-5-propionate hydrolase Vapar_6064 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) Vapar_6065 ENOG4105ERH Fumarylacetoacetate hydrolase Vapar_6071 ENOG4105JSC dimethylmenaquinone methyltransferase Vapar_6072 ENOG4105EGI Transcriptional regulator Vapar_6077 ENOG4105EN6 Membrane Vapar_6080 ENOG4108IG5 Transcriptional regulator Vapar_6082 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Vapar_6084 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Vapar_6086 ENOG4105CAF HipA N-terminal domain protein Vapar_6088 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) Vapar_6090 ENOG4105EHI Phosphonate ABC transporter, periplasmic Vapar_6091 ENOG4105D5T phosphonate abc transporter Vapar_6092 ENOG4105FD8 phosphonate metabolism protein PhnM Vapar_6093 ENOG4105HRV phosphonate c-p lyase system protein phnl Vapar_6094 ENOG4105ENV phosphonate C-P lyase system protein PhnK Vapar_6095 ENOG4105FT8 Phosphonate metabolism Vapar_6098 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG Vapar_6099 ENOG4105CMD Transcriptional regulator, GntR family Vapar_6100 ENOG4108TXN phosphonate metabolism protein Vapar_6101 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) Vapar_6103 ENOG4105BZU Histidine kinase Vapar_6104 ENOG4105BZU Histidine kinase Vapar_6105 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Vapar_6106 ENOG4105BZU Histidine kinase Vapar_6109 ENOG4105FA0 parb-like partition protein Vapar_6113 ENOG4105GAK amidohydrolase 2 Vapar_6114 ENOG4105DND Transcriptional regulator Vapar_6120 ENOG4105BZU Histidine kinase Vapar_6123 ENOG4106FGB Beta-lactamase Vapar_6126 ENOG4105ETT transcriptional Regulator, LysR family Vapar_6130 ENOG4105C26 Dehydrogenase Vapar_6134 ENOG4108IUZ ABC transporter Vapar_6135 ENOG4108IV0 ABC, transporter Vapar_6141 ENOG4105DIQ Transcriptional regulator Vapar_6142 ENOG4105C6Z Gluconate Vapar_6143 ENOG4105CMG Carbohydrate kinase Vapar_6144 ENOG41075H3 AraC family transcriptional regulator Vapar_6146 ENOG4108UKI Enoyl-CoA hydratase Vapar_6147 ENOG4105CD5 CoA-binding domain protein Vapar_6148 ENOG4108PGP mmge prpd family protein Vapar_6150 ENOG4107RYR Transcriptional regulator, Crp Fnr family Vapar_6151 ENOG4105DDW LysR family Transcriptional regulator Vapar_6158 ENOG4105C1G acyl-Coa dehydrogenase Vapar_6160 ENOG4105BZU Histidine kinase Vapar_6161 ENOG4105CIR epoxide hydrolase Vapar_6168 ENOG4105E0F Histidine kinase Vapar_6169 ENOG4108ZXC Two component transcriptional regulator, luxr family Vapar_6170 ENOG4105BZU Histidine kinase Vapar_6177 ENOG4105CGU Enoyl-CoA hydratase Vapar_6181 ENOG4105J5T Amp-dependent synthetase and ligase Vapar_6182 ENOG4105DDW LysR family Transcriptional regulator Vapar_6185 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Vapar_6187 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Vapar_6188 ENOG4107QM5 aconitate hydratase Vapar_6191 ENOG4105EJC lysr family transcriptional regulator Vapar_6200 ENOG4105C0R drug resistance transporter emrb qaca subfamily Vapar_6201 ENOG4108J2P Alpha beta hydrolase fold Vapar_6203 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Vapar_6204 ENOG4108IG5 Transcriptional regulator Vapar_6205 ENOG4105EMU Dehydrogenase Vapar_6206 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family Vapar_6210 ENOG4105EXG Transcriptional regulator Vapar_6214 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Vapar_6221 ENOG4105CEY Amp-dependent synthetase and ligase Vapar_6224 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Vapar_6230 ENOG4105KKX ATPase associated with various cellular activities aaa_5 Vapar_6231 ENOG4108KDT Molybdate metabolism regulator Vapar_6233 ENOG4105DEG Vwa containing coxe family protein Vapar_6242 ENOG4105DZG Dehydrogenase Vapar_6247 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) Vapar_6251 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Vapar_6261 ENOG4105C01 Dihydroxy-acid dehydratase Vapar_6262 ENOG4105GAK amidohydrolase 2 Vapar_6264 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Vapar_6267 ENOG4105DRS transport system, permease Vapar_6268 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Vapar_6270 ENOG4105CPT Alpha beta hydrolase Vapar_6279 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Vapar_6283 ENOG4107RH7 Nicotinate phosphoribosyltransferase Vapar_6286 ENOG41065RQ ADP-ribosylation crystallin J1 Vapar_6287 ENOG4105R0I Feruloyl esterase Vapar_6290 ENOG4108ZCF integral membrane protein Vapar_6295 ENOG4105C9U ATP-dependent DNA helicase RecQ Vapar_6297 ENOG4105WD1 Membrane Vapar_6299 ENOG4108IJF Heavy metal efflux pump, CzcA Vapar_6300 ENOG4105EP1 Efflux transporter rnd family, mfp subunit Vapar_6305 ENOG4105E18 UPF0276 protein Vapar_6311 ENOG4105EV4 Multidrug resistance protein mdtH Vapar_6312 ENOG4105VUH addiction module killer protein Vapar_6313 ENOG4105YES addiction module antidote protein Vapar_6314 ENOG4105EMU Dehydrogenase Vapar_6315 ENOG4105EMN RNA polymerase sigma factor Vapar_6327 ENOG4105DZQ phospholipase D Transphosphatidylase Vapar_6330 ENOG41080XP Cbs domain Vapar_6331 ENOG4108Z0Z intracellular protease Pfpi family Vapar_6335 ENOG4105CMQ Chloride channel Vapar_6347 ENOG4105ECQ AraC Family Transcriptional Regulator Vapar_6349 ENOG4108N8Y HfaB protein Vapar_6351 ENOG4105CKT filamentous hemagglutinin Vapar_6356 ENOG4105D5K Hemolysin activator protein Vapar_6359 ENOG4105JSC dimethylmenaquinone methyltransferase Vapar_6360 ENOG4105CHM Aminotransferase Vapar_6362 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Vapar_6363 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Vapar_6364 ENOG4105P4J Allophanate hydrolase, subunit 1 Vapar_6365 ENOG4107R7A Allophanate hydrolase subunit 2 Vapar_6369 ENOG4108HW4 amino acid AbC transporter Vapar_6370 ENOG4105DRP amino acid AbC transporter Vapar_6379 ENOG4105EA8 2-Nitropropane dioxygenase Vapar_6380 ENOG4105EMN RNA polymerase sigma factor