locus-tag	class	description
Vapar_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vapar_0002	COG0592	DNA-directed DNA polymerase activity
Vapar_0003	COG0187	DNA topoisomerase II activity
Vapar_0008	COG1408	metallophosphoesterase
Vapar_0010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Vapar_0011	COG0392	lysyltransferase activity
Vapar_0012	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_0013	COG3568	Endonuclease Exonuclease Phosphatase
Vapar_0019	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Vapar_0023	COG4452	Inner membrane protein CreD
Vapar_0026	COG2205	protein histidine kinase activity
Vapar_0027	COG0745	RESPONSE REGULATOR receiver
Vapar_0030	COG2608	mercury ion transmembrane transporter activity
Vapar_0031	COG2217	Heavy metal translocating P-type atpase
Vapar_0032	COG0456	acetyltransferase
Vapar_0033	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vapar_0036	COG0745	RESPONSE REGULATOR receiver
Vapar_0037	COG0642	Histidine kinase
Vapar_0039	COG1902	pentaerythritol trinitrate reductase activity
Vapar_0041	COG1024	Enoyl-CoA hydratase
Vapar_0045	COG0445	tRNA wobble uridine modification
Vapar_0046	COG0357	Ribosomal RNA small subunit methyltransferase G
Vapar_0048	COG1192	Involved in chromosome partitioning
Vapar_0052	COG0277	FAD linked oxidase domain protein
Vapar_0054	COG2096	Adenosyltransferase
Vapar_0061	COG0583	DNA-binding transcription factor activity
Vapar_0065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Vapar_0066	COG2894	cell division
Vapar_0067	COG0850	regulation of cytokinetic process
Vapar_0068	COG2233	PERMEase
Vapar_0069	COG2050	protein possibly involved in aromatic compounds catabolism
Vapar_0072	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_0074	COG3246	L-lysine catabolic process to acetate
Vapar_0077	COG3284	Transcriptional regulator
Vapar_0078	COG1942	4-Oxalocrotonate Tautomerase
Vapar_0079	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0082	COG2207	Transcriptional regulator
Vapar_0092	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Vapar_0099	COG0492	ferredoxin-NADP+ reductase activity
Vapar_0101	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Vapar_0102	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_0103	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_0104	COG1116	anion transmembrane transporter activity
Vapar_0107	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vapar_0108	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Vapar_0111	COG0154	amidase activity
Vapar_0114	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_0116	COG1950	PFAM Membrane protein of
Vapar_0117	COG0583	DNA-binding transcription factor activity
Vapar_0118	COG1960	acyl-CoA dehydrogenase activity
Vapar_0119	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_0121	COG1276	copper resistance
Vapar_0123	COG1573	uracil-dna glycosylase
Vapar_0128	COG3246	L-lysine catabolic process to acetate
Vapar_0129	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0130	COG3485	protocatechuate 3,4-dioxygenase
Vapar_0134	COG0583	DNA-binding transcription factor activity
Vapar_0135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vapar_0137	COG2066	Belongs to the glutaminase family
Vapar_0140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Vapar_0141	COG0700	Nucleoside recognition
Vapar_0142	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_0147	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Vapar_0149	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vapar_0150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vapar_0153	COG0514	ATP-dependent DNA helicase (RecQ)
Vapar_0155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_0158	COG2986	histidine ammonia-lyase
Vapar_0159	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Vapar_0164	COG1228	amidohydrolase
Vapar_0165	COG0402	S-adenosylhomocysteine deaminase activity
Vapar_0171	COG1410	methionine synthase
Vapar_0171	COG0646	methionine synthase
Vapar_0176	COG1309	transcriptional regulator
Vapar_0185	COG0411	ABC transporter
Vapar_0187	COG1335	isochorismatase
Vapar_0189	COG2080	2 iron, 2 sulfur cluster binding
Vapar_0190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vapar_0190	COG2010	Cytochrome c
Vapar_0201	COG3501	Rhs element vgr protein
Vapar_0215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vapar_0215	COG0515	serine threonine protein kinase
Vapar_0216	COG0606	chelatase, subunit chli
Vapar_0218	COG0347	Belongs to the P(II) protein family
Vapar_0219	COG0004	ammonium transporteR
Vapar_0222	COG0277	FAD linked oxidase domain protein
Vapar_0223	COG0277	FAD linked oxidase domain protein
Vapar_0224	COG0247	lactate metabolic process
Vapar_0226	COG0386	Belongs to the glutathione peroxidase family
Vapar_0228	COG0477	Major facilitator Superfamily
Vapar_0229	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vapar_0234	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vapar_0237	COG0129	dihydroxy-acid dehydratase activity
Vapar_0240	COG3971	2-oxopent-4-enoate hydratase activity
Vapar_0242	COG3384	dioxygenase
Vapar_0243	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_0246	COG1846	Transcriptional regulator
Vapar_0248	COG3209	COG3209 Rhs family protein
Vapar_0248	COG3209	COG3209 Rhs family protein
Vapar_0250	COG3501	Rhs element vgr protein
Vapar_0253	COG2974	May be involved in recombination
Vapar_0260	COG0579	oxidoreductase
Vapar_0263	COG2211	Major facilitator Superfamily
Vapar_0267	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_0273	COG1335	isochorismatase
Vapar_0277	COG0708	Exodeoxyribonuclease III
Vapar_0278	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vapar_0280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Vapar_0281	COG0154	amidase activity
Vapar_0282	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Vapar_0283	COG1077	Cell shape determining protein MreB Mrl
Vapar_0286	COG0768	penicillin binding
Vapar_0289	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Vapar_0294	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Vapar_0298	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Vapar_0299	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Vapar_0300	COG0583	DNA-binding transcription factor activity
Vapar_0303	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_0306	COG1177	transmembrane transport
Vapar_0307	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vapar_0308	COG3842	ATPase activity
Vapar_0313	COG0028	Belongs to the TPP enzyme family
Vapar_0319	COG0724	RNA recognition motif
Vapar_0321	COG0023	Translation Initiation Factor
Vapar_0322	COG0513	Belongs to the DEAD box helicase family
Vapar_0323	COG0330	HflC and HflK could
Vapar_0324	COG1960	acyl-CoA dehydrogenase activity
Vapar_0326	COG0439	Biotin carboxylase
Vapar_0327	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vapar_0330	COG2733	membrane
Vapar_0332	COG0584	glycerophosphoryl diester phosphodiesterase
Vapar_0333	COG1473	amidohydrolase
Vapar_0336	COG0243	molybdopterin cofactor binding
Vapar_0339	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0340	COG1070	Carbohydrate kinase
Vapar_0341	COG1063	alcohol dehydrogenase
Vapar_0342	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vapar_0343	COG1129	ABC transporter
Vapar_0344	COG1879	ABC-type sugar transport system periplasmic component
Vapar_0345	COG2207	Transcriptional regulator
Vapar_0346	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_0355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vapar_0357	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_0358	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vapar_0359	COG1946	Acyl-CoA thioesterase
Vapar_0360	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0362	COG0410	ABC transporter
Vapar_0363	COG0411	ABC transporter
Vapar_0370	COG0667	Aldo Keto reductase
Vapar_0371	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vapar_0375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Vapar_0379	COG0629	single-stranded DNA binding
Vapar_0382	COG0217	transcriptional regulatory protein
Vapar_0386	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Vapar_0387	COG0482	sulfurtransferase activity
Vapar_0391	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Vapar_0392	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Vapar_0393	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Vapar_0394	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_0395	COG0601	transmembrane transport
Vapar_0396	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_0397	COG0444	Belongs to the ABC transporter superfamily
Vapar_0398	COG4608	Belongs to the ABC transporter superfamily
Vapar_0399	COG0747	negative chemotaxis
Vapar_0400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Vapar_0403	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Vapar_0405	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Vapar_0406	COG0735	belongs to the Fur family
Vapar_0407	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vapar_0411	COG0058	SHG alpha-glucan phosphorylase activity
Vapar_0412	COG0297	glycogen (starch) synthase activity
Vapar_0413	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Vapar_0414	COG1523	belongs to the glycosyl hydrolase 13 family
Vapar_0415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Vapar_0416	COG0366	Alpha amylase catalytic
Vapar_0417	COG2072	flavoprotein involved in K transport
Vapar_0422	COG0495	leucyl-tRNA aminoacylation
Vapar_0425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Vapar_0427	COG3158	transport of potassium into the cell
Vapar_0431	COG3135	benzoate transporter
Vapar_0432	COG0189	ligase activity
Vapar_0435	COG0121	glutamine amidotransferase
Vapar_0437	COG2814	Major facilitator Superfamily
Vapar_0440	COG0205	6-phosphofructokinase activity
Vapar_0444	COG1024	Enoyl-CoA hydratase
Vapar_0445	COG0183	Belongs to the thiolase family
Vapar_0447	COG0583	DNA-binding transcription factor activity
Vapar_0451	COG4804	nuclease activity
Vapar_0452	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Vapar_0454	COG1414	Transcriptional regulator
Vapar_0455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vapar_0456	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_0461	COG0018	arginyl-trna synthetase
Vapar_0463	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vapar_0464	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Vapar_0465	COG1137	ATPase activity
Vapar_0466	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Vapar_0467	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_0478	COG0069	glutamate synthase activity
Vapar_0479	COG0653	protein targeting
Vapar_0484	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Vapar_0488	COG1335	isochorismatase
Vapar_0490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Vapar_0493	COG2967	ApaG domain
Vapar_0494	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Vapar_0508	COG5002	protein histidine kinase activity
Vapar_0510	COG2205	protein histidine kinase activity
Vapar_0510	COG2198	Histidine kinase
Vapar_0510	COG0784	Response regulator, receiver
Vapar_0512	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Vapar_0513	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Vapar_0519	COG0515	serine threonine protein kinase
Vapar_0531	COG3501	Rhs element vgr protein
Vapar_0536	COG3501	Rhs element vgr protein
Vapar_0556	COG2072	flavoprotein involved in K transport
Vapar_0558	COG2144	transferase activity, transferring acyl groups
Vapar_0563	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vapar_0571	COG0546	phosphoglycolate phosphatase activity
Vapar_0575	COG0512	Glutamine amidotransferase of anthranilate synthase
Vapar_0577	COG1280	lysine exporter protein (LysE YggA)
Vapar_0578	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vapar_0579	COG0134	indole-3-glycerol-phosphate synthase activity
Vapar_0580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Vapar_0581	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vapar_0584	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Vapar_0585	COG0081	regulation of translation
Vapar_0586	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Vapar_0587	COG0222	ribosome binding
Vapar_0588	COG0085	RNA polymerase activity
Vapar_0589	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vapar_0593	COG5000	phosphorelay sensor kinase activity
Vapar_0594	COG2204	response regulator
Vapar_0595	COG2963	transposase activity
Vapar_0612	COG2272	Belongs to the type-B carboxylesterase lipase family
Vapar_0616	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vapar_0618	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Vapar_0620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_0621	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Vapar_0622	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_0623	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vapar_0624	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0627	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0635	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_0636	COG4638	Rieske (2fe-2S)
Vapar_0637	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
Vapar_0638	COG1335	isochorismatase
Vapar_0647	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Vapar_0654	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vapar_0661	COG0625	glutathione transferase activity
Vapar_0662	COG1017	nitric oxide dioxygenase activity
Vapar_0662	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vapar_0664	COG3436	PFAM IS66 Orf2 family protein
Vapar_0665	COG4372	Transposase
Vapar_0678	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_0681	COG1484	DNA-dependent DNA replication
Vapar_0686	COG0582	viral genome integration into host DNA
Vapar_0687	COG0840	transmembrane signaling receptor activity
Vapar_0691	COG0668	transmembrane transport
Vapar_0696	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vapar_0699	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vapar_0702	COG0438	transferase activity, transferring glycosyl groups
Vapar_0709	COG0154	amidase activity
Vapar_0710	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_0712	COG0776	regulation of translation
Vapar_0713	COG0583	DNA-binding transcription factor activity
Vapar_0716	COG5001	Diguanylate cyclase
Vapar_0716	COG5002	protein histidine kinase activity
Vapar_0716	COG3447	MASE1 domain protein
Vapar_0717	COG2205	protein histidine kinase activity
Vapar_0718	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vapar_0721	COG0210	DNA helicase
Vapar_0722	COG0679	Auxin Efflux Carrier
Vapar_0726	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Vapar_0727	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Vapar_0729	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Vapar_0735	COG0583	DNA-binding transcription factor activity
Vapar_0736	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0738	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vapar_0741	COG0384	phenazine biosynthesis protein PhzF
Vapar_0742	COG0625	glutathione transferase activity
Vapar_0745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vapar_0746	COG0697	spore germination
Vapar_0751	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_0757	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Vapar_0758	COG0438	transferase activity, transferring glycosyl groups
Vapar_0761	COG0438	transferase activity, transferring glycosyl groups
Vapar_0766	COG0662	Cupin 2, conserved barrel domain protein
Vapar_0766	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Vapar_0767	COG1216	Glycosyl transferase, family 2
Vapar_0767	COG0438	transferase activity, transferring glycosyl groups
Vapar_0770	COG2755	lipolytic protein G-D-S-L family
Vapar_0770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Vapar_0773	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vapar_0774	COG1216	Glycosyl transferase, family 2
Vapar_0774	COG0438	transferase activity, transferring glycosyl groups
Vapar_0775	COG1216	Glycosyl transferase, family 2
Vapar_0775	COG0438	transferase activity, transferring glycosyl groups
Vapar_0778	COG0753	catalase activity
Vapar_0782	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Vapar_0783	COG2721	sulfolactate sulfo-lyase activity
Vapar_0784	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vapar_0786	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_0787	COG2186	Transcriptional regulator
Vapar_0788	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0789	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_0790	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vapar_0791	COG2188	Transcriptional regulator
Vapar_0796	COG0410	ABC transporter
Vapar_0798	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vapar_0799	COG0066	3-isopropylmalate dehydratase activity
Vapar_0807	COG0583	DNA-binding transcription factor activity
Vapar_0808	COG4221	oxidoreductase activity
Vapar_0810	COG1960	acyl-CoA dehydrogenase activity
Vapar_0812	COG1024	Enoyl-CoA hydratase
Vapar_0812	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_0813	COG2852	Protein conserved in bacteria
Vapar_0814	COG0183	Belongs to the thiolase family
Vapar_0820	COG1024	Enoyl-CoA hydratase
Vapar_0821	COG0683	leucine binding
Vapar_0822	COG1607	acyl-coa hydrolase
Vapar_0823	COG5265	(ABC) transporter
Vapar_0824	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vapar_0825	COG0154	amidase activity
Vapar_0826	COG0583	DNA-binding transcription factor activity
Vapar_0827	COG1027	Aspartate ammonia-lyase
Vapar_0828	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vapar_0829	COG0765	amino acid transport
Vapar_0830	COG0765	amino acid transport
Vapar_0831	COG1126	abc transporter atp-binding protein
Vapar_0833	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_0835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vapar_0836	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_0837	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_0838	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_0839	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_0840	COG1024	Enoyl-CoA hydratase
Vapar_0841	COG1960	acyl-CoA dehydrogenase activity
Vapar_0842	COG1960	acyl-CoA dehydrogenase activity
Vapar_0843	COG0183	Belongs to the thiolase family
Vapar_0844	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_0844	COG1024	Enoyl-CoA hydratase
Vapar_0845	COG0583	DNA-binding transcription factor activity
Vapar_0846	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Vapar_0848	COG0154	amidase activity
Vapar_0849	COG0444	Belongs to the ABC transporter superfamily
Vapar_0850	COG4608	Belongs to the ABC transporter superfamily
Vapar_0851	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_0853	COG0747	negative chemotaxis
Vapar_0854	COG0418	dihydroorotase activity
Vapar_0859	COG0501	Belongs to the peptidase M48B family
Vapar_0862	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Vapar_0863	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Vapar_0864	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Vapar_0869	COG1566	PFAM secretion protein HlyD family protein
Vapar_0871	COG2814	Major facilitator Superfamily
Vapar_0873	COG1187	pseudouridine synthase activity
Vapar_0874	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vapar_0875	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_0886	COG0662	Cupin 2, conserved barrel domain protein
Vapar_0886	COG2207	Transcriptional regulator
Vapar_0891	COG1484	DNA-dependent DNA replication
Vapar_0894	COG3501	Rhs element vgr protein
Vapar_0899	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Vapar_0902	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Vapar_0903	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vapar_0904	COG0523	cobalamin synthesis protein
Vapar_0906	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Vapar_0908	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Vapar_0909	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Vapar_0910	COG2001	Belongs to the MraZ family
Vapar_0911	COG0275	rRNA processing
Vapar_0912	COG3116	cell division
Vapar_0914	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Vapar_0915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Vapar_0916	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Vapar_0917	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Vapar_0918	COG0772	Belongs to the SEDS family
Vapar_0919	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Vapar_0920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vapar_0921	COG1181	Belongs to the D-alanine--D-alanine ligase family
Vapar_0922	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Vapar_0925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Vapar_0928	COG0583	DNA-binding transcription factor activity
Vapar_0929	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vapar_0930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Vapar_0931	COG0575	Belongs to the CDS family
Vapar_0935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vapar_0938	COG3150	esterase
Vapar_0939	COG2197	response regulator
Vapar_0941	COG0772	Belongs to the SEDS family
Vapar_0942	COG0312	modulator of DNA gyrase
Vapar_0944	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vapar_0946	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vapar_0948	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Vapar_0949	COG0511	ligase activity, forming carbon-carbon bonds
Vapar_0950	COG0439	Biotin carboxylase
Vapar_0951	COG2264	protein methyltransferase activity
Vapar_0955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vapar_0956	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vapar_0956	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Vapar_0962	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vapar_0965	COG2204	response regulator
Vapar_0967	COG2205	protein histidine kinase activity
Vapar_0968	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vapar_0971	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vapar_0974	COG0037	tRNA processing
Vapar_0978	COG2175	clavaminate synthase activity
Vapar_0983	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vapar_0985	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Vapar_0986	COG3387	PFAM Glycoside hydrolase 15-related
Vapar_0988	COG0617	tRNA 3'-terminal CCA addition
Vapar_0990	COG0625	glutathione transferase activity
Vapar_0991	COG1285	pathogenesis
Vapar_0992	COG0741	lytic transglycosylase activity
Vapar_0993	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Vapar_0994	COG0583	DNA-binding transcription factor activity
Vapar_0997	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vapar_0999	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Vapar_1000	COG1522	sequence-specific DNA binding
Vapar_1001	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Vapar_1002	COG3177	Filamentation induced by cAMP protein fic
Vapar_1003	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vapar_1013	COG3411	Ferredoxin
Vapar_1021	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Vapar_1026	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_1028	COG0583	DNA-binding transcription factor activity
Vapar_1030	COG2951	lytic endotransglycosylase activity
Vapar_1035	COG0697	spore germination
Vapar_1036	COG0583	DNA-binding transcription factor activity
Vapar_1037	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Vapar_1040	COG3386	PFAM SMP-30 Gluconolaconase
Vapar_1041	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1043	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_1044	COG1879	ABC-type sugar transport system periplasmic component
Vapar_1045	COG4213	ABC transporter substrate-binding protein
Vapar_1047	COG4214	carbohydrate transport
Vapar_1048	COG1129	ABC transporter
Vapar_1049	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vapar_1050	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vapar_1053	COG0583	DNA-binding transcription factor activity
Vapar_1054	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1059	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Vapar_1059	COG0189	ligase activity
Vapar_1060	COG1132	(ABC) transporter
Vapar_1063	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vapar_1064	COG4178	(ABC) transporter
Vapar_1067	COG2271	Major facilitator Superfamily
Vapar_1083	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vapar_1086	COG1765	OsmC-like protein
Vapar_1087	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Vapar_1089	COG0601	transmembrane transport
Vapar_1091	COG0747	negative chemotaxis
Vapar_1092	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_1093	COG0444	Belongs to the ABC transporter superfamily
Vapar_1094	COG4608	Belongs to the ABC transporter superfamily
Vapar_1095	COG3384	dioxygenase
Vapar_1096	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Vapar_1097	COG1840	ABC-type Fe3 transport system, periplasmic component
Vapar_1099	COG3842	ATPase activity
Vapar_1102	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Vapar_1103	COG0166	Belongs to the GPI family
Vapar_1109	COG1175	transmembrane transport
Vapar_1110	COG0395	ABC-type sugar transport system, permease component
Vapar_1111	COG3842	ATPase activity
Vapar_1112	COG0246	Mannitol dehydrogenase
Vapar_1114	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Vapar_1116	COG2207	Transcriptional regulator
Vapar_1116	COG4753	response regulator
Vapar_1117	COG1070	Carbohydrate kinase
Vapar_1118	COG0459	protein refolding
Vapar_1119	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Vapar_1121	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_1125	COG4772	TonB-dependent receptor
Vapar_1126	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Vapar_1128	COG1560	Kdo2-lipid A biosynthetic process
Vapar_1130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Vapar_1132	COG1333	cytochrome c biogenesis protein
Vapar_1133	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vapar_1134	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Vapar_1135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Vapar_1136	COG0019	diaminopimelate decarboxylase activity
Vapar_1138	COG1965	Belongs to the frataxin family
Vapar_1145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Vapar_1146	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Vapar_1147	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Vapar_1152	COG0067	glutamate synthase
Vapar_1152	COG0069	glutamate synthase activity
Vapar_1152	COG0070	glutamate synthase
Vapar_1154	COG1127	ABC transporter
Vapar_1155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Vapar_1156	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Vapar_1157	COG2853	Lipoprotein
Vapar_1160	COG1131	(ABC) transporter
Vapar_1161	COG0842	Transport permease protein
Vapar_1162	COG5007	Belongs to the BolA IbaG family
Vapar_1163	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Vapar_1164	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vapar_1167	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vapar_1168	COG0131	Imidazoleglycerol-phosphate dehydratase
Vapar_1170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vapar_1173	COG1301	dicarboxylic acid transport
Vapar_1175	COG0107	imidazoleglycerol-phosphate synthase activity
Vapar_1176	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vapar_1177	COG0140	phosphoribosyl-ATP diphosphatase activity
Vapar_1179	COG0537	adenosine 5'-monophosphoramidase activity
Vapar_1180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vapar_1181	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vapar_1182	COG0805	protein transport
Vapar_1185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Vapar_1186	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Vapar_1187	COG1970	mechanosensitive ion channel activity
Vapar_1189	COG1596	polysaccharide export
Vapar_1191	COG3206	protein involved in exopolysaccharide biosynthesis
Vapar_1191	COG0489	protein tyrosine kinase activity
Vapar_1197	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vapar_1200	COG0723	plastoquinol--plastocyanin reductase activity
Vapar_1201	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Vapar_1202	COG2857	Cytochrome c1
Vapar_1203	COG0625	glutathione transferase activity
Vapar_1204	COG2969	positive regulation of protein catabolic process
Vapar_1207	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1208	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Vapar_1210	COG4591	ABC-type transport system involved in lipoprotein release permease component
Vapar_1211	COG1136	(ABC) transporter
Vapar_1212	COG0740	serine-type endopeptidase activity
Vapar_1215	COG0601	transmembrane transport
Vapar_1221	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Vapar_1222	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Vapar_1226	COG2030	dehydratase
Vapar_1226	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_1228	COG0411	ABC transporter
Vapar_1231	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vapar_1232	COG2151	metal-sulfur cluster biosynthetic enzyme
Vapar_1233	COG3396	Phenylacetate-CoA oxygenase
Vapar_1234	COG3460	Phenylacetate-CoA oxygenase
Vapar_1235	COG3396	Phenylacetate-CoA oxygenase
Vapar_1237	COG2050	protein possibly involved in aromatic compounds catabolism
Vapar_1238	COG1024	Enoyl-CoA hydratase
Vapar_1240	COG1309	transcriptional regulator
Vapar_1241	COG2304	oxidoreductase activity
Vapar_1243	COG0714	Associated with various cellular activities
Vapar_1244	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vapar_1245	COG0084	hydrolase, TatD family'
Vapar_1248	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Vapar_1249	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vapar_1252	COG0583	DNA-binding transcription factor activity
Vapar_1256	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1260	COG1283	sodium-dependent phosphate transmembrane transporter activity
Vapar_1262	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Vapar_1266	COG1609	Transcriptional regulator
Vapar_1267	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Vapar_1269	COG0196	riboflavin kinase activity
Vapar_1274	COG1960	acyl-CoA dehydrogenase activity
Vapar_1275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Vapar_1279	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vapar_1279	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vapar_1281	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Vapar_1282	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Vapar_1283	COG0492	ferredoxin-NADP+ reductase activity
Vapar_1285	COG1674	ftsk spoiiie
Vapar_1286	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Vapar_1287	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Vapar_1288	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_1290	COG0411	ABC transporter
Vapar_1293	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vapar_1293	COG0543	2 iron, 2 sulfur cluster binding
Vapar_1297	COG2816	NAD+ diphosphatase activity
Vapar_1298	COG0425	Belongs to the sulfur carrier protein TusA family
Vapar_1300	COG0525	valine-tRNA ligase activity
Vapar_1301	COG3022	response to hydroperoxide
Vapar_1303	COG2267	carboxylic ester hydrolase activity
Vapar_1304	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vapar_1304	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vapar_1305	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1308	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_1309	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_1312	COG1960	acyl-CoA dehydrogenase activity
Vapar_1314	COG1960	acyl-CoA dehydrogenase activity
Vapar_1316	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_1323	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vapar_1330	COG0477	Major facilitator Superfamily
Vapar_1331	COG1304	FMN binding
Vapar_1332	COG0583	DNA-binding transcription factor activity
Vapar_1335	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Vapar_1336	COG4221	oxidoreductase activity
Vapar_1337	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vapar_1338	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vapar_1341	COG2807	transmembrane transport
Vapar_1342	COG2186	Transcriptional regulator
Vapar_1345	COG1280	lysine exporter protein (LysE YggA)
Vapar_1349	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Vapar_1354	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Vapar_1361	COG0165	Argininosuccinate lyase
Vapar_1362	COG3275	phosphorelay sensor kinase activity
Vapar_1370	COG0583	DNA-binding transcription factor activity
Vapar_1373	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Vapar_1374	COG0181	hydroxymethylbilane synthase activity
Vapar_1378	COG1530	ribonuclease E activity
Vapar_1382	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vapar_1382	COG0616	signal peptide processing
Vapar_1383	COG2223	nitrite transmembrane transporter activity
Vapar_1384	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Vapar_1385	COG0424	maF-like protein
Vapar_1386	COG1399	metal-binding, possibly nucleic acid-binding protein
Vapar_1387	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Vapar_1388	COG0416	fatty acid biosynthetic process
Vapar_1389	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vapar_1391	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1392	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vapar_1393	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vapar_1398	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vapar_1399	COG0481	GTPase activity
Vapar_1400	COG0681	Belongs to the peptidase S26 family
Vapar_1402	COG0571	ribonuclease III activity
Vapar_1403	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Vapar_1404	COG1381	Involved in DNA repair and RecF pathway recombination
Vapar_1405	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Vapar_1406	COG0736	holo-[acyl-carrier-protein] synthase activity
Vapar_1407	COG1472	Belongs to the glycosyl hydrolase 3 family
Vapar_1408	COG1451	nucleotide metabolic process
Vapar_1409	COG0443	Heat shock 70 kDa protein
Vapar_1410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Vapar_1412	COG0762	integral membrane protein
Vapar_1413	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Vapar_1414	COG0159	tryptophan synthase activity
Vapar_1415	COG0133	tryptophan synthase activity
Vapar_1416	COG0135	phosphoribosylanthranilate isomerase activity
Vapar_1417	COG0101	tRNA pseudouridine synthase activity
Vapar_1419	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vapar_1420	COG0473	3-isopropylmalate dehydrogenase activity
Vapar_1421	COG0066	3-isopropylmalate dehydratase activity
Vapar_1422	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vapar_1425	COG0372	Belongs to the citrate synthase family
Vapar_1426	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Vapar_1427	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Vapar_1428	COG1053	succinate dehydrogenase
Vapar_1431	COG2188	Transcriptional regulator
Vapar_1432	COG0039	L-malate dehydrogenase activity
Vapar_1433	COG4106	trans-aconitate 2-methyltransferase activity
Vapar_1440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Vapar_1445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vapar_1447	COG3483	tryptophan 2,3-dioxygenase activity
Vapar_1449	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Vapar_1451	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vapar_1452	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vapar_1454	COG0268	Binds directly to 16S ribosomal RNA
Vapar_1455	COG0728	peptidoglycan biosynthetic process
Vapar_1458	COG3795	YCII-related domain
Vapar_1459	COG3795	YCII-related domain
Vapar_1460	COG4941	Belongs to the sigma-70 factor family
Vapar_1461	COG1917	Cupin 2, conserved barrel domain protein
Vapar_1461	COG4977	sequence-specific DNA binding
Vapar_1465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vapar_1466	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vapar_1467	COG0617	tRNA 3'-terminal CCA addition
Vapar_1469	COG1392	Phosphate transport regulator
Vapar_1470	COG0306	phosphate transporter
Vapar_1473	COG0228	four-way junction DNA binding
Vapar_1474	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Vapar_1475	COG0336	Belongs to the RNA methyltransferase TrmD family
Vapar_1476	COG0335	large ribosomal subunit rRNA binding
Vapar_1478	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Vapar_1479	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vapar_1480	COG1162	GTPase activity
Vapar_1481	COG2154	pterin-4-alpha-carbinolamine dehydratase
Vapar_1482	COG0501	Belongs to the peptidase M48B family
Vapar_1483	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Vapar_1484	COG0513	Belongs to the DEAD box helicase family
Vapar_1485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Vapar_1486	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_1488	COG3321	synthase
Vapar_1488	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1488	COG0604	alcohol dehydrogenase
Vapar_1493	COG4638	Rieske (2fe-2S)
Vapar_1498	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Vapar_1499	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1501	COG0683	leucine binding
Vapar_1505	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_1506	COG0411	ABC transporter
Vapar_1510	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_1519	COG4964	Belongs to the GSP D family
Vapar_1531	COG2197	response regulator
Vapar_1534	COG0516	GMP reductase activity
Vapar_1535	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Vapar_1536	COG0210	DNA helicase
Vapar_1540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Vapar_1546	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vapar_1548	COG0412	Dienelactone hydrolase
Vapar_1551	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Vapar_1552	COG4608	Belongs to the ABC transporter superfamily
Vapar_1553	COG0444	Belongs to the ABC transporter superfamily
Vapar_1554	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_1555	COG0601	transmembrane transport
Vapar_1556	COG0747	negative chemotaxis
Vapar_1561	COG3064	Membrane
Vapar_1569	COG1722	exodeoxyribonuclease VII activity
Vapar_1570	COG0142	geranyltranstransferase activity
Vapar_1571	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Vapar_1572	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Vapar_1573	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vapar_1575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Vapar_1576	COG0477	Major facilitator Superfamily
Vapar_1577	COG1910	domain protein
Vapar_1580	COG2188	Transcriptional regulator
Vapar_1582	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_1589	COG1122	ATPase activity
Vapar_1596	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Vapar_1599	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Vapar_1599	COG3608	succinylglutamate desuccinylase aspartoacylase
Vapar_1600	COG1320	monovalent cation:proton antiporter activity
Vapar_1601	COG2212	antiporter activity
Vapar_1603	COG0651	ATP synthesis coupled electron transport
Vapar_1604	COG1006	Multisubunit Na H antiporter MnhC subunit
Vapar_1605	COG2111	Na H antiporter
Vapar_1605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Vapar_1606	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Vapar_1609	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_1611	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Vapar_1615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vapar_1616	COG0287	Prephenate dehydrogenase
Vapar_1617	COG1605	Chorismate mutase
Vapar_1617	COG0077	Prephenate dehydratase
Vapar_1618	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Vapar_1622	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vapar_1624	COG4797	methyltransferase
Vapar_1624	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vapar_1626	COG1187	pseudouridine synthase activity
Vapar_1631	COG1546	Belongs to the CinA family
Vapar_1631	COG1058	Belongs to the CinA family
Vapar_1634	COG3852	Histidine kinase
Vapar_1637	COG0708	Exodeoxyribonuclease III
Vapar_1642	COG0583	DNA-binding transcription factor activity
Vapar_1643	COG0583	DNA-binding transcription factor activity
Vapar_1644	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_1647	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Vapar_1649	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_1655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Vapar_1657	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vapar_1658	COG5002	protein histidine kinase activity
Vapar_1659	COG0392	lysyltransferase activity
Vapar_1664	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Vapar_1668	COG0277	FAD linked oxidase domain protein
Vapar_1670	COG1295	ribonuclease BN
Vapar_1672	COG3118	belongs to the thioredoxin family
Vapar_1673	COG0702	epimerase
Vapar_1674	COG0583	DNA-binding transcription factor activity
Vapar_1676	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_1677	COG2267	carboxylic ester hydrolase activity
Vapar_1681	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vapar_1682	COG0583	DNA-binding transcription factor activity
Vapar_1686	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_1687	COG4638	Rieske (2fe-2S)
Vapar_1694	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Vapar_1698	COG3070	regulator of competence-specific genes
Vapar_1699	COG0346	lactoylglutathione lyase activity
Vapar_1701	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Vapar_1702	COG0596	Alpha beta hydrolase
Vapar_1704	COG0625	glutathione transferase activity
Vapar_1707	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Vapar_1708	COG2719	SpoVR family
Vapar_1709	COG2718	Belongs to the UPF0229 family
Vapar_1710	COG2766	serine protein kinase
Vapar_1711	COG0484	heat shock protein binding
Vapar_1712	COG0443	Heat shock 70 kDa protein
Vapar_1713	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Vapar_1716	COG0688	phosphatidylethanolamine metabolic process
Vapar_1717	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_1718	COG2706	6-phosphogluconolactonase activity
Vapar_1721	COG2721	sulfolactate sulfo-lyase activity
Vapar_1722	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vapar_1724	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_1726	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vapar_1727	COG2186	Transcriptional regulator
Vapar_1728	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_1729	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_1732	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_1734	COG0583	DNA-binding transcription factor activity
Vapar_1738	COG0842	Transport permease protein
Vapar_1739	COG0842	Transport permease protein
Vapar_1740	COG1131	(ABC) transporter
Vapar_1743	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_1745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vapar_1746	COG1802	Transcriptional regulator
Vapar_1752	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Vapar_1755	COG0583	DNA-binding transcription factor activity
Vapar_1756	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vapar_1757	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_1761	COG2814	Major facilitator Superfamily
Vapar_1762	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Vapar_1763	COG0358	DNA primase activity
Vapar_1764	COG1959	2 iron, 2 sulfur cluster binding
Vapar_1764	COG1295	ribonuclease BN
Vapar_1768	COG0123	including yeast histone deacetylase and acetoin utilization protein
Vapar_1769	COG0824	Thioesterase
Vapar_1771	COG3237	CsbD-like
Vapar_1772	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Vapar_1774	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vapar_1775	COG1322	Protein conserved in bacteria
Vapar_1777	COG1611	Belongs to the LOG family
Vapar_1778	COG1024	Enoyl-CoA hydratase
Vapar_1779	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Vapar_1782	COG0405	Gamma-glutamyltransferase
Vapar_1783	COG0322	excinuclease ABC activity
Vapar_1786	COG0583	DNA-binding transcription factor activity
Vapar_1787	COG0596	Alpha beta hydrolase
Vapar_1788	COG0473	3-isopropylmalate dehydrogenase activity
Vapar_1790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vapar_1797	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vapar_1798	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vapar_1801	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vapar_1802	COG0670	Belongs to the BI1 family
Vapar_1803	COG3193	protein, possibly involved in utilization of glycolate and propanediol
Vapar_1808	COG4774	siderophore transport
Vapar_1809	COG3128	pkhd-type hydroxylase
Vapar_1815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Vapar_1818	COG0360	Binds together with S18 to 16S ribosomal RNA
Vapar_1819	COG2965	DNA replication, synthesis of RNA primer
Vapar_1820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Vapar_1821	COG0359	binds to the 23S rRNA
Vapar_1822	COG0305	Participates in initiation and elongation during chromosome replication
Vapar_1827	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Vapar_1828	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vapar_1830	COG0436	Aminotransferase
Vapar_1832	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vapar_1833	COG1763	Mo-molybdopterin cofactor biosynthetic process
Vapar_1834	COG0303	'Molybdopterin
Vapar_1835	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Vapar_1836	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_1837	COG0314	molybdopterin synthase activity
Vapar_1838	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_1839	COG0542	response to heat
Vapar_1841	COG0183	Belongs to the thiolase family
Vapar_1844	COG0659	secondary active sulfate transmembrane transporter activity
Vapar_1846	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vapar_1847	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vapar_1854	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Vapar_1855	COG3214	Protein conserved in bacteria
Vapar_1858	COG0673	inositol 2-dehydrogenase activity
Vapar_1861	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_1862	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_1864	COG1309	transcriptional regulator
Vapar_1865	COG0028	Belongs to the TPP enzyme family
Vapar_1870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vapar_1871	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Vapar_1872	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Vapar_1873	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Vapar_1874	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Vapar_1875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vapar_1875	COG0072	phenylalanine-tRNA ligase activity
Vapar_1876	COG0776	regulation of translation
Vapar_1883	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_1886	COG1126	abc transporter atp-binding protein
Vapar_1887	COG0765	amino acid transport
Vapar_1891	COG1045	serine acetyltransferase
Vapar_1893	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vapar_1894	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vapar_1899	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_1905	COG1464	Belongs to the NlpA lipoprotein family
Vapar_1910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_1911	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_1914	COG0745	RESPONSE REGULATOR receiver
Vapar_1914	COG4191	Histidine kinase
Vapar_1914	COG2205	protein histidine kinase activity
Vapar_1915	COG0583	DNA-binding transcription factor activity
Vapar_1916	COG1335	isochorismatase
Vapar_1925	COG1596	polysaccharide export
Vapar_1926	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Vapar_1934	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vapar_1937	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Vapar_1940	COG0489	protein tyrosine kinase activity
Vapar_1940	COG3206	protein involved in exopolysaccharide biosynthesis
Vapar_1941	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Vapar_1942	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vapar_1945	COG1850	ribulose-bisphosphate carboxylase activity
Vapar_1947	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vapar_1948	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_1949	COG1609	Transcriptional regulator
Vapar_1951	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_1952	COG2721	sulfolactate sulfo-lyase activity
Vapar_1960	COG0431	NADPH-dependent FMN reductase
Vapar_1963	COG0798	PFAM Bile acid sodium symporter
Vapar_1965	COG2199	diguanylate cyclase activity
Vapar_1965	COG3287	FIST C domain
Vapar_1965	COG2200	EAL domain
Vapar_1966	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vapar_1969	COG0366	Alpha amylase catalytic
Vapar_1978	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Vapar_1979	COG0366	Alpha amylase catalytic
Vapar_1980	COG0366	Alpha amylase catalytic
Vapar_1983	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Vapar_1984	COG1640	4-alpha-glucanotransferase
Vapar_1991	COG2226	methyltransferase
Vapar_1999	COG0028	Belongs to the TPP enzyme family
Vapar_2001	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Vapar_2002	COG1335	isochorismatase
Vapar_2011	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_2014	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_2016	COG3045	CreA protein
Vapar_2022	COG3243	poly(R)-hydroxyalkanoic acid synthase
Vapar_2023	COG0183	Belongs to the thiolase family
Vapar_2024	COG0583	DNA-binding transcription factor activity
Vapar_2026	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Vapar_2030	COG1058	Belongs to the CinA family
Vapar_2030	COG1546	Belongs to the CinA family
Vapar_2031	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_2032	COG1301	dicarboxylic acid transport
Vapar_2033	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Vapar_2033	COG4651	solute:proton antiporter activity
Vapar_2042	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_2044	COG2249	NAD(P)H dehydrogenase (quinone) activity
Vapar_2045	COG0583	DNA-binding transcription factor activity
Vapar_2047	COG1522	sequence-specific DNA binding
Vapar_2048	COG0028	Belongs to the TPP enzyme family
Vapar_2054	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Vapar_2056	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Vapar_2071	COG4171	peptide transport system, permease
Vapar_2072	COG4172	Belongs to the ABC transporter superfamily
Vapar_2075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Vapar_2078	COG1475	DNA binding
Vapar_2080	COG5489	Protein of unknown function (DUF736)
Vapar_2087	COG1192	Involved in chromosome partitioning
Vapar_2094	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_2095	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_2096	COG1960	acyl-CoA dehydrogenase activity
Vapar_2097	COG0583	DNA-binding transcription factor activity
Vapar_2098	COG0456	acetyltransferase
Vapar_2105	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_2106	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Vapar_2107	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Vapar_2126	COG1802	Transcriptional regulator
Vapar_2129	COG1703	isobutyryl-CoA mutase activity
Vapar_2130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vapar_2131	COG0439	Biotin carboxylase
Vapar_2132	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Vapar_2134	COG1522	sequence-specific DNA binding
Vapar_2135	COG0697	spore germination
Vapar_2137	COG2878	Part of a membrane complex involved in electron transport
Vapar_2141	COG1959	2 iron, 2 sulfur cluster binding
Vapar_2142	COG1104	cysteine desulfurase activity
Vapar_2143	COG0822	iron-sulfur transferase activity
Vapar_2146	COG0443	Heat shock 70 kDa protein
Vapar_2147	COG0633	Ferredoxin
Vapar_2152	COG0579	oxidoreductase
Vapar_2155	COG0167	dihydroorotate dehydrogenase activity
Vapar_2156	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Vapar_2159	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Vapar_2160	COG4566	intracellular signal transduction
Vapar_2162	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Vapar_2163	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vapar_2164	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Vapar_2165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vapar_2166	COG0791	NLP P60 protein
Vapar_2167	COG2133	pyrroloquinoline quinone binding
Vapar_2171	COG0567	Dehydrogenase, E1 component
Vapar_2172	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vapar_2173	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vapar_2174	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Vapar_2178	COG1199	ATP-dependent helicase activity
Vapar_2180	COG0564	pseudouridine synthase activity
Vapar_2181	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Vapar_2182	COG1187	pseudouridine synthase activity
Vapar_2183	COG0105	UTP biosynthetic process
Vapar_2184	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Vapar_2187	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Vapar_2188	COG0124	histidyl-tRNA synthetase
Vapar_2191	COG1160	GTP binding
Vapar_2192	COG1923	regulation of RNA biosynthetic process
Vapar_2193	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Vapar_2194	COG0330	HflC and HflK could
Vapar_2195	COG0330	HflC and HflK could
Vapar_2197	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Vapar_2198	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vapar_2203	COG0626	cystathionine gamma-synthase activity
Vapar_2206	COG1136	(ABC) transporter
Vapar_2208	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vapar_2213	COG0667	Aldo Keto reductase
Vapar_2214	COG2059	Chromate
Vapar_2216	COG1295	ribonuclease BN
Vapar_2220	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_2229	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_2230	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_2234	COG1024	Enoyl-CoA hydratase
Vapar_2259	COG1987	bacterial-type flagellum assembly
Vapar_2260	COG1684	flagellar biosynthetic protein fliR
Vapar_2261	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Vapar_2262	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Vapar_2263	COG4786	Flagellar basal body rod
Vapar_2264	COG4786	Flagellar basal body rod
Vapar_2266	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Vapar_2267	COG1706	bacterial-type flagellum-dependent cell motility
Vapar_2269	COG1558	bacterial-type flagellum-dependent cell motility
Vapar_2270	COG1677	Flagellar hook-basal body complex protein FliE
Vapar_2274	COG1157	protein secretion by the type III secretion system
Vapar_2277	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Vapar_2283	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Vapar_2295	COG3039	Transposase
Vapar_2301	COG0582	viral genome integration into host DNA
Vapar_2303	COG0625	glutathione transferase activity
Vapar_2304	COG0492	ferredoxin-NADP+ reductase activity
Vapar_2311	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Vapar_2312	COG0573	inorganic phosphate transmembrane transporter activity
Vapar_2313	COG0581	inorganic phosphate transmembrane transporter activity
Vapar_2314	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vapar_2318	COG0534	Mate efflux family protein
Vapar_2320	COG0254	rRNA binding
Vapar_2321	COG0673	inositol 2-dehydrogenase activity
Vapar_2322	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Vapar_2331	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Vapar_2332	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Vapar_2334	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_2336	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_2337	COG0741	lytic transglycosylase activity
Vapar_2337	COG1388	LysM domain
Vapar_2338	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vapar_2339	COG2226	methyltransferase
Vapar_2340	COG0328	RNA-DNA hybrid ribonuclease activity
Vapar_2341	COG0303	'Molybdopterin
Vapar_2342	COG0746	molybdenum cofactor guanylyltransferase activity
Vapar_2343	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vapar_2344	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_2346	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_2358	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Vapar_2360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vapar_2360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vapar_2363	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Vapar_2368	COG0028	Belongs to the TPP enzyme family
Vapar_2369	COG0440	acetolactate synthase activity
Vapar_2371	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vapar_2372	COG1183	phosphatidylcholine synthase activity
Vapar_2373	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vapar_2374	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vapar_2376	COG1414	Transcriptional regulator
Vapar_2377	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Vapar_2378	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Vapar_2383	COG1414	Transcriptional regulator
Vapar_2384	COG0745	RESPONSE REGULATOR receiver
Vapar_2385	COG0642	Histidine kinase
Vapar_2386	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vapar_2394	COG4773	Receptor
Vapar_2396	COG2022	thiamine diphosphate biosynthetic process
Vapar_2399	COG0351	phosphomethylpyrimidine kinase
Vapar_2402	COG0492	ferredoxin-NADP+ reductase activity
Vapar_2403	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Vapar_2404	COG0529	Catalyzes the synthesis of activated sulfate
Vapar_2404	COG2895	sulfate adenylyltransferase (ATP) activity
Vapar_2409	COG2801	Transposase and inactivated derivatives
Vapar_2409	COG3415	Transposase
Vapar_2414	COG2204	response regulator
Vapar_2418	COG0411	ABC transporter
Vapar_2420	COG0410	ABC transporter
Vapar_2425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Vapar_2473	COG0740	serine-type endopeptidase activity
Vapar_2501	COG1011	Hydrolase
Vapar_2504	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Vapar_2505	COG1562	ergosterol biosynthetic process
Vapar_2508	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vapar_2510	COG0544	peptidyl-prolyl cis-trans isomerase activity
Vapar_2511	COG0740	serine-type endopeptidase activity
Vapar_2512	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Vapar_2513	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Vapar_2517	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Vapar_2519	COG2113	Glycine betaine
Vapar_2520	COG4176	ABC-type proline glycine betaine transport system permease component
Vapar_2522	COG0114	fumarate hydratase activity
Vapar_2523	COG2910	NAD(P)H-binding
Vapar_2524	COG0583	DNA-binding transcription factor activity
Vapar_2526	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vapar_2528	COG4654	Cytochrome c, class I
Vapar_2530	COG0129	dihydroxy-acid dehydratase activity
Vapar_2531	COG0583	DNA-binding transcription factor activity
Vapar_2532	COG0583	DNA-binding transcription factor activity
Vapar_2534	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Vapar_2535	COG1802	Transcriptional regulator
Vapar_2538	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_2541	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vapar_2542	COG4977	sequence-specific DNA binding
Vapar_2544	COG0730	response to heat
Vapar_2547	COG4206	TonB-dependent receptor
Vapar_2548	COG1797	cobyrinic acid a,c-diamide synthase activity
Vapar_2551	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vapar_2552	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vapar_2553	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Vapar_2554	COG0778	Nitroreductase
Vapar_2555	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Vapar_2556	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vapar_2562	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vapar_2565	COG1492	cobalamin metabolic process
Vapar_2566	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vapar_2567	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Vapar_2570	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_2571	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vapar_2572	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vapar_2577	COG0560	Phosphoserine phosphatase
Vapar_2578	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Vapar_2579	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Vapar_2579	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Vapar_2580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Vapar_2580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Vapar_2581	COG2205	protein histidine kinase activity
Vapar_2582	COG0745	RESPONSE REGULATOR receiver
Vapar_2585	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_2587	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vapar_2589	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Vapar_2590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vapar_2593	COG3339	Conserved Protein
Vapar_2595	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_2596	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Vapar_2596	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Vapar_2599	COG0052	Belongs to the universal ribosomal protein uS2 family
Vapar_2600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Vapar_2601	COG0528	UMP kinase activity
Vapar_2602	COG0233	cytoplasmic translational termination
Vapar_2605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Vapar_2606	COG0750	zinc metalloprotease
Vapar_2609	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vapar_2610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vapar_2611	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vapar_2612	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vapar_2613	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Vapar_2614	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vapar_2615	COG0505	Belongs to the CarA family
Vapar_2617	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Vapar_2619	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vapar_2622	COG1534	Rna-binding protein
Vapar_2623	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Vapar_2624	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vapar_2626	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vapar_2630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vapar_2631	COG1024	Enoyl-CoA hydratase
Vapar_2632	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_2633	COG2814	Major facilitator Superfamily
Vapar_2634	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vapar_2636	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Vapar_2637	COG0252	asparaginase activity
Vapar_2638	COG0563	adenylate kinase activity
Vapar_2639	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Vapar_2640	COG2835	tetraacyldisaccharide 4'-kinase activity
Vapar_2641	COG1663	tetraacyldisaccharide 4'-kinase activity
Vapar_2642	COG0848	biopolymer transport protein
Vapar_2643	COG0811	peptide transport
Vapar_2644	COG1570	exodeoxyribonuclease VII activity
Vapar_2645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Vapar_2650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Vapar_2651	COG0542	response to heat
Vapar_2652	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_2653	COG2925	Exonuclease
Vapar_2654	COG0402	S-adenosylhomocysteine deaminase activity
Vapar_2660	COG1744	ABC transporter substrate-binding protein PnrA-like
Vapar_2661	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Vapar_2666	COG1595	DNA-templated transcription, initiation
Vapar_2668	COG0433	COG0433 Predicted ATPase
Vapar_2671	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vapar_2682	COG2226	methyltransferase
Vapar_2683	COG0217	transcriptional regulatory protein
Vapar_2684	COG0151	Belongs to the GarS family
Vapar_2685	COG0408	coproporphyrinogen oxidase activity
Vapar_2686	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Vapar_2687	COG0799	negative regulation of ribosome biogenesis
Vapar_2688	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Vapar_2689	COG0424	maF-like protein
Vapar_2690	COG1530	ribonuclease E activity
Vapar_2691	COG1132	(ABC) transporter
Vapar_2692	COG0823	Involved in the tonB-independent uptake of proteins
Vapar_2693	COG2885	chlorophyll binding
Vapar_2695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Vapar_2702	COG1484	DNA-dependent DNA replication
Vapar_2703	COG4584	PFAM Integrase catalytic
Vapar_2716	COG2890	protein-(glutamine-N5) methyltransferase activity
Vapar_2717	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vapar_2719	COG2171	N-acyltransferase activity
Vapar_2721	COG1280	lysine exporter protein (LysE YggA)
Vapar_2722	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vapar_2722	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vapar_2723	COG1643	Atp-dependent helicase
Vapar_2725	COG0436	Aminotransferase
Vapar_2726	COG0583	DNA-binding transcription factor activity
Vapar_2730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Vapar_2738	COG1982	Orn Lys Arg decarboxylase major
Vapar_2739	COG1793	dna ligase
Vapar_2741	COG4166	transmembrane transport
Vapar_2742	COG4174	ABC transporter (Permease)
Vapar_2743	COG4239	(ABC) transporter, permease
Vapar_2744	COG4172	Belongs to the ABC transporter superfamily
Vapar_2745	COG0477	Major facilitator Superfamily
Vapar_2746	COG0779	Required for maturation of 30S ribosomal subunits
Vapar_2747	COG0195	Participates in both transcription termination and antitermination
Vapar_2747	COG2251	uridine kinase activity
Vapar_2748	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vapar_2749	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Vapar_2750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Vapar_2757	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Vapar_2758	COG2867	negative regulation of translational initiation
Vapar_2759	COG2914	Belongs to the UPF0125 (RnfH) family
Vapar_2764	COG0519	Catalyzes the synthesis of GMP from XMP
Vapar_2764	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vapar_2765	COG1733	regulation of RNA biosynthetic process
Vapar_2766	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_2769	COG2267	carboxylic ester hydrolase activity
Vapar_2775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Vapar_2778	COG0583	DNA-binding transcription factor activity
Vapar_2790	COG4191	Histidine kinase
Vapar_2791	COG4566	intracellular signal transduction
Vapar_2796	COG0590	tRNA wobble adenosine to inosine editing
Vapar_2797	COG1619	proteins homologs of microcin C7 resistance protein MccF
Vapar_2802	COG2205	protein histidine kinase activity
Vapar_2804	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Vapar_2806	COG1199	ATP-dependent helicase activity
Vapar_2812	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Vapar_2813	COG0667	Aldo Keto reductase
Vapar_2814	COG2207	Transcriptional regulator
Vapar_2816	COG2217	Heavy metal translocating P-type atpase
Vapar_2818	COG3278	Belongs to the heme-copper respiratory oxidase family
Vapar_2824	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vapar_2826	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Vapar_2829	COG0589	response to stress
Vapar_2845	COG2815	serine threonine protein kinase
Vapar_2845	COG0515	serine threonine protein kinase
Vapar_2849	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vapar_2850	COG3360	Dodecin
Vapar_2851	COG0432	Pfam Uncharacterised protein family UPF0047
Vapar_2854	COG0666	response to abiotic stimulus
Vapar_2855	COG0084	hydrolase, TatD family'
Vapar_2858	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vapar_2859	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Vapar_2865	COG3501	Rhs element vgr protein
Vapar_2875	COG2183	response to ionizing radiation
Vapar_2876	COG2186	Transcriptional regulator
Vapar_2879	COG1063	alcohol dehydrogenase
Vapar_2880	COG0765	amino acid transport
Vapar_2883	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_2884	COG0246	Mannitol dehydrogenase
Vapar_2889	COG0534	Mate efflux family protein
Vapar_2891	COG0477	Major facilitator Superfamily
Vapar_2893	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Vapar_2893	COG3008	intermembrane lipid transfer
Vapar_2894	COG2995	paraquat-inducible protein a
Vapar_2895	COG2995	paraquat-inducible protein a
Vapar_2896	COG2814	Major facilitator Superfamily
Vapar_2897	COG2814	Major facilitator Superfamily
Vapar_2901	COG0583	DNA-binding transcription factor activity
Vapar_2904	COG0277	FAD linked oxidase domain protein
Vapar_2904	COG0247	lactate metabolic process
Vapar_2909	COG0583	DNA-binding transcription factor activity
Vapar_2910	COG2814	Major facilitator Superfamily
Vapar_2911	COG0667	Aldo Keto reductase
Vapar_2912	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Vapar_2916	COG1960	acyl-CoA dehydrogenase activity
Vapar_2917	COG2130	NADP-dependent
Vapar_2922	COG1960	acyl-CoA dehydrogenase activity
Vapar_2923	COG0183	Belongs to the thiolase family
Vapar_2925	COG1024	Enoyl-CoA hydratase
Vapar_2925	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_2927	COG0411	ABC transporter
Vapar_2932	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_2933	COG2272	Belongs to the type-B carboxylesterase lipase family
Vapar_2935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Vapar_2936	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vapar_2937	COG2917	probably involved in intracellular septation
Vapar_2939	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vapar_2940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vapar_2940	COG0047	phosphoribosylformylglycinamidine synthase activity
Vapar_2941	COG0024	Methionine aminopeptidase
Vapar_2944	COG0765	amino acid transport
Vapar_2945	COG4597	amino acid ABC transporter
Vapar_2946	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vapar_2948	COG0242	peptide deformylase activity
Vapar_2950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Vapar_2952	COG1196	nuclear chromosome segregation
Vapar_2955	COG3550	peptidyl-serine autophosphorylation
Vapar_2957	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Vapar_2958	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Vapar_2959	COG4208	sulfate ABC transporter
Vapar_2961	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Vapar_2963	COG0450	alkyl hydroperoxide reductase
Vapar_2965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Vapar_2967	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vapar_2970	COG1045	serine acetyltransferase
Vapar_2973	COG1116	anion transmembrane transporter activity
Vapar_2974	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_2975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_2976	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Vapar_2978	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_2980	COG0431	NADPH-dependent FMN reductase
Vapar_2982	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Vapar_2983	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_2983	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Vapar_2987	COG5002	protein histidine kinase activity
Vapar_2988	COG0745	RESPONSE REGULATOR receiver
Vapar_2989	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Vapar_2990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Vapar_2992	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vapar_2993	COG3588	fructose-bisphosphate aldolase
Vapar_2994	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_2995	COG0583	DNA-binding transcription factor activity
Vapar_2999	COG0789	Transcriptional regulator
Vapar_3001	COG1446	asparaginase
Vapar_3002	COG4172	Belongs to the ABC transporter superfamily
Vapar_3003	COG0747	negative chemotaxis
Vapar_3004	COG0601	transmembrane transport
Vapar_3005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_3010	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_3012	COG0642	Histidine kinase
Vapar_3014	COG2326	polyphosphate kinase activity
Vapar_3019	COG3383	formate dehydrogenase (NAD+) activity
Vapar_3020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Vapar_3022	COG0191	fructose-bisphosphate aldolase activity
Vapar_3023	COG0126	phosphoglycerate kinase activity
Vapar_3024	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Vapar_3025	COG3954	Phosphoribulokinase
Vapar_3026	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Vapar_3029	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vapar_3030	COG0464	growth
Vapar_3032	COG1850	ribulose-bisphosphate carboxylase activity
Vapar_3033	COG0583	DNA-binding transcription factor activity
Vapar_3039	COG0842	Transport permease protein
Vapar_3039	COG1129	ABC transporter
Vapar_3041	COG2010	Cytochrome c
Vapar_3047	COG0714	Associated with various cellular activities
Vapar_3053	COG0535	radical SAM domain protein
Vapar_3056	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Vapar_3059	COG3851	Histidine kinase
Vapar_3060	COG2197	response regulator
Vapar_3062	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vapar_3062	COG0512	Glutamine amidotransferase of anthranilate synthase
Vapar_3065	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Vapar_3066	COG1229	Formylmethanofuran dehydrogenase subunit A
Vapar_3077	COG3284	Transcriptional regulator
Vapar_3079	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Vapar_3082	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Vapar_3084	COG0702	epimerase
Vapar_3086	COG0527	aspartate kinase activity
Vapar_3087	COG0037	tRNA processing
Vapar_3088	COG0825	malonyl-CoA metabolic process
Vapar_3090	COG0215	cysteine-tRNA ligase activity
Vapar_3094	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vapar_3099	COG0741	lytic transglycosylase activity
Vapar_3100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vapar_3101	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Vapar_3108	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vapar_3108	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vapar_3111	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Vapar_3112	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vapar_3113	COG0436	Aminotransferase
Vapar_3114	COG0824	Thioesterase
Vapar_3116	COG0848	biopolymer transport protein
Vapar_3120	COG1741	Belongs to the pirin family
Vapar_3123	COG1741	Belongs to the pirin family
Vapar_3125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_3125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Vapar_3126	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vapar_3127	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Vapar_3129	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vapar_3133	COG3976	FMN-binding domain protein
Vapar_3133	COG1053	succinate dehydrogenase
Vapar_3133	COG0431	NADPH-dependent FMN reductase
Vapar_3141	COG0410	ABC transporter
Vapar_3142	COG3842	ATPase activity
Vapar_3146	COG2205	protein histidine kinase activity
Vapar_3146	COG0784	Response regulator, receiver
Vapar_3146	COG2198	Histidine kinase
Vapar_3152	COG2207	Transcriptional regulator
Vapar_3156	COG0308	aminopeptidase N
Vapar_3157	COG2271	Major facilitator Superfamily
Vapar_3165	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_3166	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Vapar_3167	COG0028	Belongs to the TPP enzyme family
Vapar_3169	COG1414	Transcriptional regulator
Vapar_3172	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_3173	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_3174	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_3175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vapar_3176	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vapar_3189	COG1596	polysaccharide export
Vapar_3190	COG3206	protein involved in exopolysaccharide biosynthesis
Vapar_3190	COG0489	protein tyrosine kinase activity
Vapar_3191	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vapar_3192	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vapar_3198	COG0297	glycogen (starch) synthase activity
Vapar_3199	COG2197	response regulator
Vapar_3204	COG0587	DNA-directed DNA polymerase activity
Vapar_3205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vapar_3213	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vapar_3219	COG3384	dioxygenase
Vapar_3221	COG2197	response regulator
Vapar_3223	COG1132	(ABC) transporter
Vapar_3226	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Vapar_3228	COG1272	protein, Hemolysin III
Vapar_3230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Vapar_3232	COG0640	Transcriptional regulator
Vapar_3234	COG1183	phosphatidylcholine synthase activity
Vapar_3245	COG2818	Glycosylase
Vapar_3248	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vapar_3249	COG0583	DNA-binding transcription factor activity
Vapar_3250	COG0583	DNA-binding transcription factor activity
Vapar_3254	COG1024	Enoyl-CoA hydratase
Vapar_3260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_3265	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_3267	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vapar_3268	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_3273	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Vapar_3274	COG0545	Peptidyl-prolyl cis-trans isomerase
Vapar_3275	COG0531	amino acid
Vapar_3276	COG4303	Ethanolamine ammonia lyase large subunit
Vapar_3277	COG4302	ethanolamine ammonia-lyase activity
Vapar_3283	COG0671	phosphoesterase, PA-phosphatase related
Vapar_3285	COG0745	RESPONSE REGULATOR receiver
Vapar_3286	COG0642	Histidine kinase
Vapar_3287	COG0824	Thioesterase
Vapar_3288	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_3292	COG4336	lyase activity
Vapar_3293	COG0583	DNA-binding transcription factor activity
Vapar_3294	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vapar_3295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_3299	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Vapar_3300	COG0509	glycine decarboxylation via glycine cleavage system
Vapar_3301	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vapar_3301	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vapar_3307	COG0583	DNA-binding transcription factor activity
Vapar_3308	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_3309	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_3311	COG3959	Transketolase, thiamine diphosphate binding domain
Vapar_3312	COG3958	Transketolase
Vapar_3313	COG2084	Dehydrogenase
Vapar_3319	COG0477	Major facilitator Superfamily
Vapar_3322	COG2814	Major facilitator Superfamily
Vapar_3324	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Vapar_3325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vapar_3326	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_3327	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vapar_3328	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vapar_3329	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vapar_3330	COG1414	Transcriptional regulator
Vapar_3332	COG0745	RESPONSE REGULATOR receiver
Vapar_3333	COG0642	Histidine kinase
Vapar_3337	COG2084	Dehydrogenase
Vapar_3338	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_3339	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vapar_3340	COG1063	alcohol dehydrogenase
Vapar_3341	COG1609	Transcriptional regulator
Vapar_3342	COG3386	PFAM SMP-30 Gluconolaconase
Vapar_3343	COG1129	ABC transporter
Vapar_3347	COG3842	ATPase activity
Vapar_3349	COG1175	transmembrane transport
Vapar_3358	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vapar_3366	COG1294	oxidase, subunit
Vapar_3367	COG1271	oxidase subunit
Vapar_3368	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Vapar_3369	COG4988	ABC transporter
Vapar_3372	COG1960	acyl-CoA dehydrogenase activity
Vapar_3375	COG3264	Mechanosensitive ion channel
Vapar_3375	COG1511	domain protein
Vapar_3377	COG0714	Associated with various cellular activities
Vapar_3380	COG2951	lytic endotransglycosylase activity
Vapar_3386	COG1131	(ABC) transporter
Vapar_3393	COG0395	ABC-type sugar transport system, permease component
Vapar_3395	COG3842	ATPase activity
Vapar_3396	COG3842	ATPase activity
Vapar_3399	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Vapar_3401	COG2194	sulfuric ester hydrolase activity
Vapar_3403	COG2308	Evidence 4 Homologs of previously reported genes of
Vapar_3407	COG1305	Transglutaminase-like
Vapar_3410	COG2271	Major facilitator Superfamily
Vapar_3412	COG1609	Transcriptional regulator
Vapar_3414	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vapar_3416	COG1126	abc transporter atp-binding protein
Vapar_3418	COG0765	amino acid transport
Vapar_3419	COG0765	amino acid transport
Vapar_3421	COG1335	isochorismatase
Vapar_3427	COG1196	nuclear chromosome segregation
Vapar_3427	COG0741	lytic transglycosylase activity
Vapar_3427	COG0739	heme binding
Vapar_3428	COG0187	DNA topoisomerase II activity
Vapar_3432	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_3433	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Vapar_3434	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Vapar_3437	COG2850	peptidyl-arginine hydroxylation
Vapar_3438	COG1047	Peptidyl-prolyl cis-trans
Vapar_3440	COG0756	dUTP diphosphatase activity
Vapar_3442	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vapar_3443	COG0504	CTP synthase activity
Vapar_3444	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Vapar_3446	COG0148	phosphopyruvate hydratase activity
Vapar_3447	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Vapar_3448	COG3201	nicotinamide mononucleotide transporter
Vapar_3451	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Vapar_3453	COG2833	Protein of unknown function (DUF455)
Vapar_3455	COG0183	Belongs to the thiolase family
Vapar_3457	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_3458	COG4974	Belongs to the 'phage' integrase family
Vapar_3459	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_3461	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Vapar_3462	COG0802	atpase or kinase
Vapar_3463	COG0860	N-Acetylmuramoyl-L-alanine amidase
Vapar_3465	COG0586	Pfam SNARE associated Golgi protein
Vapar_3466	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Vapar_3468	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Vapar_3469	COG0577	efflux transmembrane transporter activity
Vapar_3469	COG1136	(ABC) transporter
Vapar_3472	COG5285	phytanoyl-CoA dioxygenase
Vapar_3474	COG3795	YCII-related domain
Vapar_3475	COG4941	Belongs to the sigma-70 factor family
Vapar_3479	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Vapar_3484	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_3487	COG0411	ABC transporter
Vapar_3490	COG1566	PFAM secretion protein HlyD family protein
Vapar_3492	COG1846	Transcriptional regulator
Vapar_3493	COG1132	(ABC) transporter
Vapar_3495	COG0494	nUDIX hydrolase
Vapar_3497	COG1007	ATP synthesis coupled electron transport
Vapar_3500	COG0713	ATP synthesis coupled electron transport
Vapar_3502	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vapar_3503	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Vapar_3504	COG1034	ATP synthesis coupled electron transport
Vapar_3507	COG0649	NAD binding
Vapar_3508	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vapar_3509	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vapar_3510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vapar_3512	COG0149	triose-phosphate isomerase activity
Vapar_3514	COG1185	polyribonucleotide nucleotidyltransferase activity
Vapar_3515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Vapar_3517	COG0683	leucine binding
Vapar_3520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vapar_3521	COG3707	response regulator
Vapar_3522	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_3523	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_3524	COG1116	anion transmembrane transporter activity
Vapar_3526	COG2223	nitrite transmembrane transporter activity
Vapar_3527	COG2815	serine threonine protein kinase
Vapar_3527	COG0515	serine threonine protein kinase
Vapar_3528	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vapar_3530	COG0243	molybdopterin cofactor binding
Vapar_3531	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vapar_3533	COG3842	ATPase activity
Vapar_3535	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vapar_3536	COG3833	ABC-type maltose transport systems, permease component
Vapar_3538	COG0791	NLP P60 protein
Vapar_3539	COG2081	HI0933 family
Vapar_3540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Vapar_3541	COG1610	YqeY-like protein
Vapar_3542	COG0494	nUDIX hydrolase
Vapar_3549	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Vapar_3549	COG1672	PFAM Archaeal ATPase
Vapar_3552	COG0312	modulator of DNA gyrase
Vapar_3554	COG0521	Mo-molybdopterin cofactor biosynthetic process
Vapar_3560	COG0642	Histidine kinase
Vapar_3561	COG0475	glutathione-regulated potassium exporter activity
Vapar_3563	COG0789	Transcriptional regulator
Vapar_3564	COG1045	serine acetyltransferase
Vapar_3567	COG1289	transmembrane transporter activity
Vapar_3569	COG1522	sequence-specific DNA binding
Vapar_3571	COG2311	Membrane
Vapar_3572	COG0583	DNA-binding transcription factor activity
Vapar_3574	COG1846	Transcriptional regulator
Vapar_3577	COG3119	arylsulfatase activity
Vapar_3582	COG1858	cytochrome C peroxidase
Vapar_3586	COG2375	cellular response to nickel ion
Vapar_3587	COG0598	Magnesium transport protein CorA
Vapar_3589	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Vapar_3592	COG2197	response regulator
Vapar_3594	COG4585	Histidine kinase
Vapar_3599	COG1968	undecaprenyl-diphosphatase activity
Vapar_3601	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vapar_3602	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vapar_3603	COG1737	Transcriptional regulator
Vapar_3605	COG1538	Outer membrane efflux protein
Vapar_3606	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vapar_3607	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vapar_3608	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vapar_3612	COG2972	Histidine kinase
Vapar_3615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vapar_3620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vapar_3621	COG0004	ammonium transporteR
Vapar_3622	COG3279	Response regulator of the LytR AlgR family
Vapar_3629	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Vapar_3631	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vapar_3631	COG0517	IMP dehydrogenase activity
Vapar_3633	COG0789	Transcriptional regulator
Vapar_3635	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_3637	COG2918	glutathione biosynthetic process
Vapar_3639	COG0400	carboxylic ester hydrolase activity
Vapar_3648	COG2354	Protein conserved in bacteria
Vapar_3651	COG4628	conserved protein (DUF2132)
Vapar_3654	COG0564	pseudouridine synthase activity
Vapar_3658	COG3415	Transposase
Vapar_3658	COG2801	Transposase and inactivated derivatives
Vapar_3659	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Vapar_3660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Vapar_3661	COG1252	NADH dehydrogenase
Vapar_3662	COG1525	nuclease
Vapar_3663	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_3664	COG1764	response to oxidative stress
Vapar_3668	COG0765	amino acid transport
Vapar_3669	COG0765	amino acid transport
Vapar_3673	COG0584	glycerophosphoryl diester phosphodiesterase
Vapar_3677	COG3191	aminopeptidase activity
Vapar_3681	COG0488	(ABC) transporter
Vapar_3682	COG0513	Belongs to the DEAD box helicase family
Vapar_3684	COG3842	ATPase activity
Vapar_3686	COG1175	transmembrane transport
Vapar_3688	COG2186	Transcriptional regulator
Vapar_3689	COG0129	dihydroxy-acid dehydratase activity
Vapar_3691	COG0800	Aldolase
Vapar_3692	COG0235	Class ii aldolase
Vapar_3699	COG1840	ABC-type Fe3 transport system, periplasmic component
Vapar_3701	COG3842	ATPase activity
Vapar_3703	COG0346	lactoylglutathione lyase activity
Vapar_3705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Vapar_3707	COG0800	Aldolase
Vapar_3712	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Vapar_3713	COG0259	pyridoxamine-phosphate oxidase activity
Vapar_3716	COG0679	Auxin Efflux Carrier
Vapar_3719	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vapar_3720	COG1309	transcriptional regulator
Vapar_3721	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vapar_3726	COG2169	Transcriptional regulator
Vapar_3728	COG0697	spore germination
Vapar_3732	COG0625	glutathione transferase activity
Vapar_3741	COG4774	siderophore transport
Vapar_3755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vapar_3757	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vapar_3762	COG0285	dihydrofolate synthase activity
Vapar_3763	COG1393	Belongs to the ArsC family
Vapar_3765	COG3123	guanosine phosphorylase activity
Vapar_3766	COG0137	argininosuccinate synthase activity
Vapar_3768	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Vapar_3769	COG1666	GTP binding
Vapar_3771	COG0251	oxidation-reduction process
Vapar_3772	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Vapar_3773	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Vapar_3774	COG0667	Aldo Keto reductase
Vapar_3775	COG2267	carboxylic ester hydrolase activity
Vapar_3778	COG3501	Rhs element vgr protein
Vapar_3786	COG1464	Belongs to the NlpA lipoprotein family
Vapar_3787	COG2011	ABC-type metal ion transport system permease component
Vapar_3788	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Vapar_3789	COG1464	Belongs to the NlpA lipoprotein family
Vapar_3792	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vapar_3793	COG0308	aminopeptidase N
Vapar_3795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Vapar_3805	COG0582	viral genome integration into host DNA
Vapar_3810	COG2080	2 iron, 2 sulfur cluster binding
Vapar_3811	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Vapar_3812	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vapar_3813	COG3302	dmso reductase anchor subunit
Vapar_3814	COG0437	4 iron, 4 sulfur cluster binding
Vapar_3815	COG0243	molybdopterin cofactor binding
Vapar_3816	COG0583	DNA-binding transcription factor activity
Vapar_3818	COG2721	sulfolactate sulfo-lyase activity
Vapar_3819	COG2721	sulfolactate sulfo-lyase activity
Vapar_3820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vapar_3821	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Vapar_3824	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Vapar_3826	COG1414	Transcriptional regulator
Vapar_3831	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_3832	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_3835	COG1414	Transcriptional regulator
Vapar_3838	COG2771	luxR family
Vapar_3842	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vapar_3842	COG2010	Cytochrome c
Vapar_3843	COG0583	DNA-binding transcription factor activity
Vapar_3844	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_3846	COG4521	taurine ABC transporter
Vapar_3847	COG2801	Transposase and inactivated derivatives
Vapar_3847	COG3415	Transposase
Vapar_3848	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vapar_3855	COG1253	flavin adenine dinucleotide binding
Vapar_3856	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Vapar_3859	COG3501	Rhs element vgr protein
Vapar_3865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_3867	COG1116	anion transmembrane transporter activity
Vapar_3868	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_3869	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_3871	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Vapar_3873	COG1960	acyl-CoA dehydrogenase activity
Vapar_3874	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_3878	COG0513	Belongs to the DEAD box helicase family
Vapar_3879	COG2321	neutral zinc metallopeptidase
Vapar_3880	COG0717	Belongs to the dCTP deaminase family
Vapar_3881	COG0402	S-adenosylhomocysteine deaminase activity
Vapar_3883	COG2366	antibiotic biosynthetic process
Vapar_3884	COG4977	sequence-specific DNA binding
Vapar_3885	COG0583	DNA-binding transcription factor activity
Vapar_3886	COG2814	Major facilitator Superfamily
Vapar_3887	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vapar_3888	COG4654	Cytochrome c, class I
Vapar_3890	COG0604	alcohol dehydrogenase
Vapar_3897	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_3899	COG0583	DNA-binding transcription factor activity
Vapar_3904	COG2252	PERMEase
Vapar_3906	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vapar_3919	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Vapar_3925	COG2351	hydroxyisourate hydrolase activity
Vapar_3926	COG2186	Transcriptional regulator
Vapar_3929	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vapar_3932	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vapar_3935	COG1953	Uracil, thiamine, allantoin
Vapar_3938	COG1309	transcriptional regulator
Vapar_3941	COG2233	PERMEase
Vapar_3942	COG0656	L-ascorbic acid biosynthetic process
Vapar_3944	COG4566	intracellular signal transduction
Vapar_3945	COG0477	Major facilitator Superfamily
Vapar_3948	COG1301	dicarboxylic acid transport
Vapar_3950	COG0628	permease
Vapar_3953	COG0583	DNA-binding transcription factor activity
Vapar_3954	COG3960	tartronate-semialdehyde synthase activity
Vapar_3955	COG3622	Belongs to the hyi family
Vapar_3956	COG2084	Dehydrogenase
Vapar_3958	COG0281	malic enzyme
Vapar_3958	COG0280	phosphate acetyltransferase
Vapar_3960	COG1116	anion transmembrane transporter activity
Vapar_3961	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_3967	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_3969	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vapar_3970	COG0590	tRNA wobble adenosine to inosine editing
Vapar_3971	COG0829	nickel cation binding
Vapar_3972	COG0583	DNA-binding transcription factor activity
Vapar_3981	COG2879	small protein
Vapar_3982	COG1966	Carbon starvation protein
Vapar_3984	COG0791	NLP P60 protein
Vapar_3996	COG0667	Aldo Keto reductase
Vapar_3997	COG3540	Alkaline phosphatase
Vapar_3998	COG0584	glycerophosphoryl diester phosphodiesterase
Vapar_3999	COG0395	ABC-type sugar transport system, permease component
Vapar_4000	COG1175	transmembrane transport
Vapar_4003	COG2390	Transcriptional regulator
Vapar_4005	COG1595	DNA-templated transcription, initiation
Vapar_4007	COG2814	Major facilitator Superfamily
Vapar_4011	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_4015	COG0477	Major facilitator Superfamily
Vapar_4021	COG0613	PHP domain protein
Vapar_4023	COG0009	L-threonylcarbamoyladenylate synthase
Vapar_4024	COG1994	Peptidase M50
Vapar_4025	COG0180	Tryptophanyl-tRNA synthetase
Vapar_4026	COG2197	response regulator
Vapar_4028	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Vapar_4030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vapar_4031	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Vapar_4032	COG1047	Peptidyl-prolyl cis-trans
Vapar_4033	COG2003	Belongs to the UPF0758 family
Vapar_4037	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Vapar_4039	COG0765	amino acid transport
Vapar_4040	COG0765	amino acid transport
Vapar_4042	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
Vapar_4044	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vapar_4045	COG0477	Major facilitator Superfamily
Vapar_4046	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Vapar_4047	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vapar_4048	COG1845	cytochrome c oxidase, subunit III
Vapar_4049	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Vapar_4052	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Vapar_4053	COG1272	protein, Hemolysin III
Vapar_4056	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Vapar_4057	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Vapar_4061	COG0437	4 iron, 4 sulfur cluster binding
Vapar_4062	COG3383	formate dehydrogenase (NAD+) activity
Vapar_4062	COG0243	molybdopterin cofactor binding
Vapar_4065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Vapar_4069	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vapar_4070	COG4149	molybdate abc transporter
Vapar_4072	COG3383	formate dehydrogenase (NAD+) activity
Vapar_4074	COG0583	DNA-binding transcription factor activity
Vapar_4075	COG0489	protein tyrosine kinase activity
Vapar_4077	COG3132	Protein of unknown function, DUF480
Vapar_4078	COG3698	Phosphodiester glycosidase
Vapar_4079	COG0473	3-isopropylmalate dehydrogenase activity
Vapar_4080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Vapar_4081	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vapar_4081	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vapar_4088	COG0659	secondary active sulfate transmembrane transporter activity
Vapar_4092	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Vapar_4093	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Vapar_4094	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Vapar_4095	COG0602	queuosine metabolic process
Vapar_4097	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Vapar_4099	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Vapar_4100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Vapar_4102	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vapar_4103	COG0588	phosphoglycerate mutase activity
Vapar_4104	COG0793	Belongs to the peptidase S41A family
Vapar_4105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vapar_4106	COG2982	Protein involved in outer membrane biogenesis
Vapar_4108	COG2197	response regulator
Vapar_4115	COG2823	Periplasmic or secreted lipoprotein
Vapar_4120	COG3568	Endonuclease Exonuclease Phosphatase
Vapar_4121	COG0494	nUDIX hydrolase
Vapar_4122	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Vapar_4125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vapar_4126	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Vapar_4129	COG2226	methyltransferase
Vapar_4133	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vapar_4135	COG1175	transmembrane transport
Vapar_4136	COG0395	ABC-type sugar transport system, permease component
Vapar_4137	COG3842	ATPase activity
Vapar_4138	COG0584	glycerophosphoryl diester phosphodiesterase
Vapar_4139	COG1511	domain protein
Vapar_4139	COG3264	Mechanosensitive ion channel
Vapar_4150	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Vapar_4151	COG0745	RESPONSE REGULATOR receiver
Vapar_4154	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Vapar_4155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Vapar_4165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Vapar_4169	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Vapar_4170	COG1317	bacterial-type flagellum organization
Vapar_4172	COG2882	bacterial-type flagellum organization
Vapar_4174	COG1580	Controls the rotational direction of flagella during chemotaxis
Vapar_4178	COG1338	Plays a role in the flagellum-specific transport system
Vapar_4179	COG1987	bacterial-type flagellum assembly
Vapar_4182	COG1256	bacterial-type flagellum assembly
Vapar_4184	COG0840	transmembrane signaling receptor activity
Vapar_4185	COG0840	transmembrane signaling receptor activity
Vapar_4187	COG0835	chemotaxis
Vapar_4188	COG0840	transmembrane signaling receptor activity
Vapar_4190	COG0835	chemotaxis
Vapar_4191	COG1705	Flagellar rod assembly protein muramidase FlgJ
Vapar_4191	COG3951	Flagellar rod assembly protein muramidase FlgJ
Vapar_4193	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Vapar_4194	COG4786	Flagellar basal body rod
Vapar_4195	COG4787	bacterial-type flagellum-dependent cell motility
Vapar_4196	COG1749	Flagellar hook protein flgE
Vapar_4197	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Vapar_4198	COG1558	bacterial-type flagellum-dependent cell motility
Vapar_4199	COG1815	bacterial-type flagellum-dependent cell motility
Vapar_4205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vapar_4206	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Vapar_4207	COG2890	protein-(glutamine-N5) methyltransferase activity
Vapar_4208	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Vapar_4210	COG1253	flavin adenine dinucleotide binding
Vapar_4211	COG0741	lytic transglycosylase activity
Vapar_4212	COG0442	prolyl-tRNA aminoacylation
Vapar_4213	COG0494	nUDIX hydrolase
Vapar_4215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Vapar_4216	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vapar_4217	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Vapar_4218	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Vapar_4219	COG0142	geranyltranstransferase activity
Vapar_4222	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Vapar_4224	COG1696	Membrane protein involved in D-alanine export
Vapar_4226	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Vapar_4227	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Vapar_4228	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Vapar_4228	COG2755	lipolytic protein G-D-S-L family
Vapar_4229	COG0494	nUDIX hydrolase
Vapar_4231	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Vapar_4232	COG0653	protein targeting
Vapar_4235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Vapar_4236	COG0583	DNA-binding transcription factor activity
Vapar_4240	COG0831	urea catabolic process
Vapar_4242	COG0832	Belongs to the urease beta subunit family
Vapar_4243	COG0804	urea catabolic process
Vapar_4246	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Vapar_4247	COG0830	nickel cation binding
Vapar_4248	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Vapar_4255	COG0745	RESPONSE REGULATOR receiver
Vapar_4258	COG2205	protein histidine kinase activity
Vapar_4259	COG0745	RESPONSE REGULATOR receiver
Vapar_4261	COG2982	Protein involved in outer membrane biogenesis
Vapar_4267	COG1538	Outer membrane efflux protein
Vapar_4272	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_4274	COG0583	DNA-binding transcription factor activity
Vapar_4275	COG2186	Transcriptional regulator
Vapar_4280	COG2271	Major facilitator Superfamily
Vapar_4282	COG1960	acyl-CoA dehydrogenase activity
Vapar_4284	COG0596	Alpha beta hydrolase
Vapar_4293	COG2309	aminopeptidase activity
Vapar_4294	COG1335	isochorismatase
Vapar_4296	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_4299	COG0410	ABC transporter
Vapar_4301	COG0583	DNA-binding transcription factor activity
Vapar_4303	COG0837	glucose binding
Vapar_4303	COG1737	Transcriptional regulator
Vapar_4306	COG1024	Enoyl-CoA hydratase
Vapar_4307	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_4309	COG0183	Belongs to the thiolase family
Vapar_4313	COG2207	Transcriptional regulator
Vapar_4314	COG1484	DNA-dependent DNA replication
Vapar_4316	COG1289	transmembrane transporter activity
Vapar_4320	COG0583	DNA-binding transcription factor activity
Vapar_4321	COG5001	Diguanylate cyclase
Vapar_4323	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vapar_4324	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vapar_4328	COG1561	YicC-like family, N-terminal region
Vapar_4329	COG0194	GDP metabolic process
Vapar_4330	COG1758	RNA polymerase activity
Vapar_4331	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vapar_4334	COG0529	Catalyzes the synthesis of activated sulfate
Vapar_4335	COG1420	regulation of RNA biosynthetic process
Vapar_4336	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vapar_4337	COG0497	DNA recombination
Vapar_4338	COG1660	Displays ATPase and GTPase activities
Vapar_4340	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Vapar_4341	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Vapar_4344	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Vapar_4345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Vapar_4346	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Vapar_4347	COG0193	aminoacyl-tRNA hydrolase activity
Vapar_4349	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vapar_4351	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_4353	COG4608	Belongs to the ABC transporter superfamily
Vapar_4354	COG0747	negative chemotaxis
Vapar_4356	COG0154	amidase activity
Vapar_4358	COG0583	DNA-binding transcription factor activity
Vapar_4361	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Vapar_4363	COG2267	carboxylic ester hydrolase activity
Vapar_4364	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Vapar_4366	COG1984	allophanate hydrolase subunit 2
Vapar_4367	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Vapar_4368	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Vapar_4369	COG0742	ribosomal rna small subunit methyltransferase
Vapar_4372	COG0612	Peptidase, M16
Vapar_4373	COG0612	Peptidase, M16
Vapar_4377	COG2197	response regulator
Vapar_4379	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Vapar_4380	COG4335	DNA alkylation repair
Vapar_4381	COG1999	signal sequence binding
Vapar_4382	COG0109	protoheme IX farnesyltransferase activity
Vapar_4389	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Vapar_4391	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vapar_4394	COG2226	methyltransferase
Vapar_4395	COG1040	competence protein
Vapar_4396	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Vapar_4398	COG0489	protein tyrosine kinase activity
Vapar_4402	COG1024	Enoyl-CoA hydratase
Vapar_4403	COG1022	Amp-dependent synthetase and ligase
Vapar_4403	COG3320	Male sterility
Vapar_4406	COG1960	acyl-CoA dehydrogenase activity
Vapar_4410	COG2764	glyoxalase bleomycin resistance protein dioxygenase
Vapar_4414	COG5507	3-demethylubiquinone-9 3-methyltransferase
Vapar_4418	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Vapar_4419	COG0430	RNA-3'-phosphate cyclase activity
Vapar_4421	COG1690	Belongs to the RtcB family
Vapar_4422	COG0275	rRNA processing
Vapar_4423	COG4650	regulator
Vapar_4424	COG2423	ornithine cyclodeaminase activity
Vapar_4428	COG1764	response to oxidative stress
Vapar_4429	COG0745	RESPONSE REGULATOR receiver
Vapar_4433	COG0183	Belongs to the thiolase family
Vapar_4434	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Vapar_4436	COG1414	Transcriptional regulator
Vapar_4440	COG3063	Type IV pilus biogenesis stability protein PilW
Vapar_4445	COG4964	Belongs to the GSP D family
Vapar_4456	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vapar_4457	COG2274	protein secretion by the type I secretion system
Vapar_4459	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Vapar_4463	COG0583	DNA-binding transcription factor activity
Vapar_4464	COG3485	protocatechuate 3,4-dioxygenase
Vapar_4465	COG3485	protocatechuate 3,4-dioxygenase
Vapar_4467	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vapar_4473	COG0583	DNA-binding transcription factor activity
Vapar_4478	COG0469	pyruvate kinase activity
Vapar_4479	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vapar_4481	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Vapar_4482	COG0045	succinate-CoA ligase (ADP-forming) activity
Vapar_4484	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_4485	COG4191	Histidine kinase
Vapar_4495	COG0582	viral genome integration into host DNA
Vapar_4501	COG0517	IMP dehydrogenase activity
Vapar_4502	COG4974	Belongs to the 'phage' integrase family
Vapar_4522	COG2831	hemolysin activation secretion protein
Vapar_4525	COG3210	domain, Protein
Vapar_4536	COG0587	DNA-directed DNA polymerase activity
Vapar_4537	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vapar_4565	COG0537	adenosine 5'-monophosphoramidase activity
Vapar_4567	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Vapar_4568	COG1074	ATP-dependent DNA helicase activity
Vapar_4569	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Vapar_4572	COG2733	membrane
Vapar_4577	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Vapar_4580	COG0420	3'-5' exonuclease activity
Vapar_4585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Vapar_4601	COG2274	protein secretion by the type I secretion system
Vapar_4605	COG0745	RESPONSE REGULATOR receiver
Vapar_4606	COG0745	RESPONSE REGULATOR receiver
Vapar_4607	COG2205	protein histidine kinase activity
Vapar_4609	COG2207	Transcriptional regulator
Vapar_4614	COG0540	Belongs to the ATCase OTCase family
Vapar_4615	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Vapar_4616	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Vapar_4617	COG1678	Uncharacterized ACR, COG1678
Vapar_4618	COG0415	Belongs to the DNA photolyase family
Vapar_4623	COG0840	transmembrane signaling receptor activity
Vapar_4627	COG1773	rubredoxin
Vapar_4629	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vapar_4630	COG0138	bifunctional purine biosynthesis protein purh
Vapar_4633	COG1238	metal cluster binding
Vapar_4635	COG0012	GTP binding
Vapar_4636	COG1879	ABC-type sugar transport system periplasmic component
Vapar_4637	COG1129	ABC transporter
Vapar_4638	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vapar_4639	COG1609	Transcriptional regulator
Vapar_4640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vapar_4641	COG1869	D-ribose catabolic process
Vapar_4643	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vapar_4644	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vapar_4646	COG1024	Enoyl-CoA hydratase
Vapar_4651	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vapar_4653	COG2863	cytochrome
Vapar_4656	COG1230	cation diffusion facilitator family transporter
Vapar_4657	COG2255	four-way junction helicase activity
Vapar_4658	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Vapar_4659	COG2267	carboxylic ester hydrolase activity
Vapar_4660	COG0671	phosphoesterase, PA-phosphatase related
Vapar_4660	COG2453	phosphatase
Vapar_4663	COG4589	Belongs to the CDS family
Vapar_4665	COG0632	four-way junction helicase activity
Vapar_4666	COG1702	phosphate starvation-inducible protein PhoH
Vapar_4667	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Vapar_4668	COG1490	D-aminoacyl-tRNA deacylase activity
Vapar_4669	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Vapar_4673	COG0739	heme binding
Vapar_4674	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Vapar_4675	COG2814	Major facilitator Superfamily
Vapar_4676	COG0316	Belongs to the HesB IscA family
Vapar_4677	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Vapar_4678	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Vapar_4679	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Vapar_4680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Vapar_4683	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Vapar_4686	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Vapar_4693	COG2423	ornithine cyclodeaminase activity
Vapar_4695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vapar_4696	COG3842	ATPase activity
Vapar_4698	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vapar_4699	COG1177	transmembrane transport
Vapar_4701	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_4702	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Vapar_4706	COG0477	Major facilitator Superfamily
Vapar_4711	COG1254	Belongs to the acylphosphatase family
Vapar_4713	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_4716	COG1414	Transcriptional regulator
Vapar_4717	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vapar_4721	COG1024	Enoyl-CoA hydratase
Vapar_4722	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vapar_4723	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_4724	COG1960	acyl-CoA dehydrogenase activity
Vapar_4727	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vapar_4728	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Vapar_4729	COG3012	SEC-C Motif Domain Protein
Vapar_4730	COG1960	acyl-CoA dehydrogenase activity
Vapar_4732	COG0183	Belongs to the thiolase family
Vapar_4733	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Vapar_4734	COG0288	reversible hydration of carbon dioxide
Vapar_4735	COG0789	Transcriptional regulator
Vapar_4742	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vapar_4743	COG0751	glycine-tRNA ligase activity
Vapar_4744	COG0752	glycyl-tRNA synthetase alpha subunit
Vapar_4745	COG1597	lipid kinase activity
Vapar_4746	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Vapar_4747	COG0671	phosphoesterase, PA-phosphatase related
Vapar_4752	COG0583	DNA-binding transcription factor activity
Vapar_4753	COG2814	Major facilitator Superfamily
Vapar_4760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_4762	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Vapar_4763	COG4535	Mg2 and Co2 transporter CorC
Vapar_4765	COG1522	sequence-specific DNA binding
Vapar_4768	COG3186	Phenylalanine-4-hydroxylase
Vapar_4769	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_4772	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_4781	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vapar_4792	COG0439	Biotin carboxylase
Vapar_4793	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_4798	COG1309	transcriptional regulator
Vapar_4802	COG1505	serine-type exopeptidase activity
Vapar_4803	COG0010	Belongs to the arginase family
Vapar_4808	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Vapar_4815	COG2084	Dehydrogenase
Vapar_4817	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vapar_4818	COG0792	nuclease activity
Vapar_4819	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Vapar_4824	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_4826	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Vapar_4827	COG0583	DNA-binding transcription factor activity
Vapar_4831	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vapar_4832	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vapar_4833	COG1538	Outer membrane efflux protein
Vapar_4836	COG0429	hydrolase of the alpha beta-hydrolase fold
Vapar_4838	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Vapar_4839	COG1335	isochorismatase
Vapar_4840	COG0251	oxidation-reduction process
Vapar_4841	COG2267	carboxylic ester hydrolase activity
Vapar_4842	COG0778	Nitroreductase
Vapar_4843	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Vapar_4844	COG1309	transcriptional regulator
Vapar_4857	COG3118	belongs to the thioredoxin family
Vapar_4858	COG1201	RNA secondary structure unwinding
Vapar_4859	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vapar_4859	COG1793	dna ligase
Vapar_4860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vapar_4860	COG1793	dna ligase
Vapar_4863	COG0673	inositol 2-dehydrogenase activity
Vapar_4864	COG1879	ABC-type sugar transport system periplasmic component
Vapar_4865	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vapar_4868	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Vapar_4869	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Vapar_4871	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Vapar_4872	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Vapar_4873	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Vapar_4874	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Vapar_4876	COG0356	it plays a direct role in the translocation of protons across the membrane
Vapar_4878	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Vapar_4879	COG2921	Belongs to the UPF0250 family
Vapar_4880	COG0321	lipoyl(octanoyl) transferase activity
Vapar_4881	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Vapar_4883	COG0583	DNA-binding transcription factor activity
Vapar_4884	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_4885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Vapar_4889	COG2130	NADP-dependent
Vapar_4891	COG0745	RESPONSE REGULATOR receiver
Vapar_4896	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vapar_4897	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vapar_4899	COG2814	Major facilitator Superfamily
Vapar_4901	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Vapar_4903	COG0678	peroxiredoxin activity
Vapar_4904	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Vapar_4905	COG0255	Belongs to the universal ribosomal protein uL29 family
Vapar_4906	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Vapar_4907	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Vapar_4908	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Vapar_4909	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vapar_4910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vapar_4911	COG0089	rRNA binding
Vapar_4912	COG0088	Forms part of the polypeptide exit tunnel
Vapar_4913	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vapar_4916	COG0051	transcription antitermination factor activity, RNA binding
Vapar_4917	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vapar_4918	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vapar_4919	COG0049	tRNA binding
Vapar_4920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Vapar_4921	COG1686	Belongs to the peptidase S11 family
Vapar_4922	COG2945	thiolester hydrolase activity
Vapar_4927	COG0598	Magnesium transport protein CorA
Vapar_4929	COG0583	DNA-binding transcription factor activity
Vapar_4930	COG0412	Dienelactone hydrolase
Vapar_4932	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_4933	COG2095	MarC family integral membrane protein
Vapar_4937	COG0410	ABC transporter
Vapar_4938	COG0411	ABC transporter
Vapar_4940	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_4943	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Vapar_4944	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_4947	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Vapar_4948	COG1652	LysM domain
Vapar_4950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Vapar_4953	COG0574	Belongs to the PEP-utilizing enzyme family
Vapar_4953	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vapar_4956	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vapar_4957	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Vapar_4959	COG0640	Transcriptional regulator
Vapar_4962	COG0625	glutathione transferase activity
Vapar_4963	COG0583	DNA-binding transcription factor activity
Vapar_4964	COG1131	(ABC) transporter
Vapar_4966	COG1846	Transcriptional regulator
Vapar_4967	COG1764	response to oxidative stress
Vapar_4969	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Vapar_4970	COG0583	DNA-binding transcription factor activity
Vapar_4971	COG1960	acyl-CoA dehydrogenase activity
Vapar_4972	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_4973	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_4976	COG0326	Molecular chaperone. Has ATPase activity
Vapar_4977	COG1840	ABC-type Fe3 transport system, periplasmic component
Vapar_4978	COG0583	DNA-binding transcription factor activity
Vapar_4980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Vapar_4982	COG0642	Histidine kinase
Vapar_4983	COG0745	RESPONSE REGULATOR receiver
Vapar_4985	COG1187	pseudouridine synthase activity
Vapar_4986	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Vapar_4990	COG0745	RESPONSE REGULATOR receiver
Vapar_4991	COG2205	protein histidine kinase activity
Vapar_4993	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Vapar_4994	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Vapar_4995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Vapar_4998	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Vapar_5001	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vapar_5003	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vapar_5006	COG1022	Amp-dependent synthetase and ligase
Vapar_5007	COG0411	ABC transporter
Vapar_5012	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_5013	COG0693	protein deglycase activity
Vapar_5020	COG4993	Dehydrogenase
Vapar_5021	COG1940	carbohydrate kinase activity
Vapar_5022	COG1129	ABC transporter
Vapar_5023	COG4214	carbohydrate transport
Vapar_5024	COG4213	ABC transporter substrate-binding protein
Vapar_5026	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vapar_5027	COG0583	DNA-binding transcription factor activity
Vapar_5030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Vapar_5031	COG0022	dehydrogenase e1 component
Vapar_5033	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5034	COG0583	DNA-binding transcription factor activity
Vapar_5037	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vapar_5040	COG1024	Enoyl-CoA hydratase
Vapar_5041	COG1960	acyl-CoA dehydrogenase activity
Vapar_5044	COG0203	ribosomal protein L17
Vapar_5045	COG0202	RNA polymerase activity
Vapar_5046	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Vapar_5047	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Vapar_5048	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vapar_5049	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Vapar_5050	COG0201	protein transport
Vapar_5051	COG0200	Binds to the 23S rRNA
Vapar_5052	COG1841	ribosomal large subunit assembly
Vapar_5053	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Vapar_5054	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Vapar_5055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Vapar_5056	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vapar_5057	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Vapar_5058	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Vapar_5059	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Vapar_5060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Vapar_5064	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Vapar_5065	COG0783	Belongs to the Dps family
Vapar_5067	COG1280	lysine exporter protein (LysE YggA)
Vapar_5068	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Vapar_5069	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Vapar_5071	COG0343	queuine tRNA-ribosyltransferase activity
Vapar_5082	COG0284	orotidine-5'-phosphate decarboxylase activity
Vapar_5085	COG1214	PFAM Peptidase M22, glycoprotease
Vapar_5088	COG0494	nUDIX hydrolase
Vapar_5089	COG2027	D-alanyl-D-alanine carboxypeptidase
Vapar_5091	COG0009	L-threonylcarbamoyladenylate synthase
Vapar_5092	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Vapar_5093	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vapar_5096	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Vapar_5098	COG1522	sequence-specific DNA binding
Vapar_5099	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Vapar_5100	COG0469	pyruvate kinase activity
Vapar_5101	COG0126	phosphoglycerate kinase activity
Vapar_5105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vapar_5111	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Vapar_5113	COG0242	peptide deformylase activity
Vapar_5115	COG0758	DNA mediated transformation
Vapar_5116	COG2922	Belongs to the Smg family
Vapar_5118	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vapar_5119	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vapar_5120	COG1862	Preprotein translocase
Vapar_5122	COG1522	sequence-specific DNA binding
Vapar_5124	COG0765	amino acid transport
Vapar_5125	COG2814	Major facilitator Superfamily
Vapar_5129	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vapar_5130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Vapar_5134	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_5140	COG0251	oxidation-reduction process
Vapar_5142	COG3622	Belongs to the hyi family
Vapar_5143	COG0235	Class ii aldolase
Vapar_5144	COG3395	kinase activity
Vapar_5145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vapar_5146	COG2084	Dehydrogenase
Vapar_5147	COG2271	Major facilitator Superfamily
Vapar_5148	COG2186	Transcriptional regulator
Vapar_5150	COG1522	sequence-specific DNA binding
Vapar_5156	COG4566	intracellular signal transduction
Vapar_5158	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vapar_5160	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Vapar_5162	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Vapar_5163	COG1595	DNA-templated transcription, initiation
Vapar_5166	COG0625	glutathione transferase activity
Vapar_5169	COG4772	TonB-dependent receptor
Vapar_5170	COG4681	YaeQ
Vapar_5173	COG0861	Integral membrane protein TerC family
Vapar_5175	COG1950	PFAM Membrane protein of
Vapar_5176	COG4783	chaperone-mediated protein folding
Vapar_5177	COG0315	cyclic pyranopterin monophosphate synthase activity
Vapar_5185	COG4969	Belongs to the N-Me-Phe pilin family
Vapar_5189	COG0631	protein serine/threonine phosphatase activity
Vapar_5190	COG0861	Integral membrane protein TerC family
Vapar_5191	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Vapar_5192	COG0045	succinate-CoA ligase (ADP-forming) activity
Vapar_5193	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vapar_5194	COG2137	regulation of response to DNA damage stimulus
Vapar_5195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Vapar_5198	COG0642	Histidine kinase
Vapar_5200	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Vapar_5200	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Vapar_5204	COG0583	DNA-binding transcription factor activity
Vapar_5205	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_5208	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Vapar_5211	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Vapar_5212	COG0513	Belongs to the DEAD box helicase family
Vapar_5216	COG1802	Transcriptional regulator
Vapar_5219	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_5222	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_5224	COG1473	amidohydrolase
Vapar_5228	COG1802	Transcriptional regulator
Vapar_5230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vapar_5231	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vapar_5232	COG4172	Belongs to the ABC transporter superfamily
Vapar_5233	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_5235	COG0747	negative chemotaxis
Vapar_5237	COG1741	Belongs to the pirin family
Vapar_5242	COG0765	amino acid transport
Vapar_5246	COG1047	Peptidyl-prolyl cis-trans
Vapar_5254	COG1914	H( )-stimulated, divalent metal cation uptake system
Vapar_5255	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Vapar_5258	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vapar_5259	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Vapar_5260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vapar_5261	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Vapar_5262	COG0006	proline dipeptidase activity
Vapar_5263	COG0583	DNA-binding transcription factor activity
Vapar_5266	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Vapar_5270	COG0281	malic enzyme
Vapar_5270	COG0280	phosphate acetyltransferase
Vapar_5273	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Vapar_5274	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vapar_5275	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Vapar_5277	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Vapar_5280	COG2814	Major facilitator Superfamily
Vapar_5281	COG2267	carboxylic ester hydrolase activity
Vapar_5285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vapar_5286	COG1739	Uncharacterized protein family UPF0029
Vapar_5287	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vapar_5288	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Vapar_5289	COG2119	membrane
Vapar_5290	COG0724	RNA recognition motif
Vapar_5291	COG4221	oxidoreductase activity
Vapar_5293	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Vapar_5297	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Vapar_5297	COG2066	Belongs to the glutaminase family
Vapar_5298	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Vapar_5299	COG0706	membrane insertase activity
Vapar_5300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Vapar_5301	COG0594	ribonuclease P activity
Vapar_5302	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Vapar_5304	COG0583	DNA-binding transcription factor activity
Vapar_5306	COG1960	acyl-CoA dehydrogenase activity
Vapar_5310	COG3485	protocatechuate 3,4-dioxygenase
Vapar_5312	COG2814	Major facilitator Superfamily
Vapar_5319	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vapar_5321	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_5322	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5323	COG3254	rhamnose metabolic process
Vapar_5326	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5329	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_5330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_5331	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vapar_5332	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vapar_5333	COG1063	alcohol dehydrogenase
Vapar_5335	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vapar_5336	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vapar_5337	COG0596	Alpha beta hydrolase
Vapar_5338	COG0281	malic enzyme
Vapar_5338	COG0280	phosphate acetyltransferase
Vapar_5339	COG1301	dicarboxylic acid transport
Vapar_5340	COG1252	NADH dehydrogenase
Vapar_5341	COG0183	Belongs to the thiolase family
Vapar_5342	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5351	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Vapar_5352	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_5354	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5356	COG1960	acyl-CoA dehydrogenase activity
Vapar_5357	COG0183	Belongs to the thiolase family
Vapar_5358	COG1309	transcriptional regulator
Vapar_5364	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5365	COG0583	DNA-binding transcription factor activity
Vapar_5366	COG4456	Virulence-associated protein
Vapar_5367	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vapar_5378	COG3708	Transcriptional regulator
Vapar_5378	COG2207	Transcriptional regulator
Vapar_5385	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5388	COG0583	DNA-binding transcription factor activity
Vapar_5395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vapar_5396	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Vapar_5403	COG4566	intracellular signal transduction
Vapar_5404	COG2197	response regulator
Vapar_5409	COG0583	DNA-binding transcription factor activity
Vapar_5415	COG0154	amidase activity
Vapar_5416	COG3483	tryptophan 2,3-dioxygenase activity
Vapar_5418	COG0346	lactoylglutathione lyase activity
Vapar_5419	COG0655	NAD(P)H dehydrogenase (quinone) activity
Vapar_5420	COG0583	DNA-binding transcription factor activity
Vapar_5424	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Vapar_5425	COG2207	Transcriptional regulator
Vapar_5426	COG2807	transmembrane transport
Vapar_5427	COG0625	glutathione transferase activity
Vapar_5431	COG0625	glutathione transferase activity
Vapar_5435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Vapar_5439	COG0753	catalase activity
Vapar_5440	COG0583	DNA-binding transcription factor activity
Vapar_5441	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5442	COG2755	lipolytic protein G-D-S-L family
Vapar_5442	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Vapar_5445	COG0596	Alpha beta hydrolase
Vapar_5449	COG5002	protein histidine kinase activity
Vapar_5454	COG0583	DNA-binding transcription factor activity
Vapar_5455	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_5456	COG0590	tRNA wobble adenosine to inosine editing
Vapar_5457	COG2351	hydroxyisourate hydrolase activity
Vapar_5459	COG3195	allantoin biosynthetic process
Vapar_5459	COG3648	Uricase
Vapar_5470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Vapar_5472	COG1335	isochorismatase
Vapar_5473	COG1741	Belongs to the pirin family
Vapar_5474	COG0583	DNA-binding transcription factor activity
Vapar_5478	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vapar_5478	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vapar_5488	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vapar_5489	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Vapar_5490	COG2080	2 iron, 2 sulfur cluster binding
Vapar_5491	COG2207	Transcriptional regulator
Vapar_5492	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_5493	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5494	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
Vapar_5497	COG1042	CoA-binding domain protein
Vapar_5497	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vapar_5497	COG0045	succinate-CoA ligase (ADP-forming) activity
Vapar_5498	COG1024	Enoyl-CoA hydratase
Vapar_5500	COG1960	acyl-CoA dehydrogenase activity
Vapar_5502	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Vapar_5503	COG0583	DNA-binding transcription factor activity
Vapar_5512	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_5513	COG0540	Belongs to the ATCase OTCase family
Vapar_5519	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_5528	COG0366	Alpha amylase catalytic
Vapar_5531	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_5532	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_5534	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_5537	COG3842	ATPase activity
Vapar_5539	COG2186	Transcriptional regulator
Vapar_5541	COG2207	Transcriptional regulator
Vapar_5541	COG1917	Cupin 2, conserved barrel domain protein
Vapar_5542	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vapar_5544	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5545	COG1620	l-lactate permease
Vapar_5548	COG0028	Belongs to the TPP enzyme family
Vapar_5551	COG4221	oxidoreductase activity
Vapar_5552	COG1902	pentaerythritol trinitrate reductase activity
Vapar_5556	COG2197	response regulator
Vapar_5565	COG2070	2-Nitropropane dioxygenase
Vapar_5567	COG0640	Transcriptional regulator
Vapar_5568	COG2391	methyltransferase activity
Vapar_5571	COG0671	phosphoesterase, PA-phosphatase related
Vapar_5572	COG0463	Glycosyl transferase, family 2
Vapar_5573	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Vapar_5575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vapar_5580	COG4191	Histidine kinase
Vapar_5580	COG0784	Response regulator, receiver
Vapar_5584	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_5585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vapar_5586	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vapar_5588	COG0028	Belongs to the TPP enzyme family
Vapar_5589	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_5591	COG0765	amino acid transport
Vapar_5592	COG1126	abc transporter atp-binding protein
Vapar_5594	COG1522	sequence-specific DNA binding
Vapar_5597	COG0251	oxidation-reduction process
Vapar_5598	COG2186	Transcriptional regulator
Vapar_5599	COG0473	3-isopropylmalate dehydrogenase activity
Vapar_5599	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vapar_5604	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_5606	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vapar_5607	COG1126	abc transporter atp-binding protein
Vapar_5615	COG1053	succinate dehydrogenase
Vapar_5622	COG0583	DNA-binding transcription factor activity
Vapar_5623	COG0154	amidase activity
Vapar_5625	COG0477	Major facilitator Superfamily
Vapar_5628	COG1522	sequence-specific DNA binding
Vapar_5629	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vapar_5630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vapar_5633	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vapar_5634	COG4166	transmembrane transport
Vapar_5635	COG0601	transmembrane transport
Vapar_5636	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vapar_5638	COG0473	3-isopropylmalate dehydrogenase activity
Vapar_5639	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_5640	COG0789	Transcriptional regulator
Vapar_5641	COG0494	nUDIX hydrolase
Vapar_5650	COG0583	DNA-binding transcription factor activity
Vapar_5651	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_5652	COG3485	protocatechuate 3,4-dioxygenase
Vapar_5655	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_5667	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vapar_5668	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_5671	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5674	COG0583	DNA-binding transcription factor activity
Vapar_5675	COG0583	DNA-binding transcription factor activity
Vapar_5676	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_5678	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5679	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_5680	COG3501	Rhs element vgr protein
Vapar_5681	COG3209	COG3209 Rhs family protein
Vapar_5690	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_5691	COG0745	RESPONSE REGULATOR receiver
Vapar_5691	COG3706	GGDEF domain
Vapar_5692	COG2814	Major facilitator Superfamily
Vapar_5700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vapar_5704	COG2186	Transcriptional regulator
Vapar_5710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vapar_5714	COG3321	synthase
Vapar_5714	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5714	COG0604	alcohol dehydrogenase
Vapar_5717	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vapar_5721	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_5722	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Vapar_5723	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_5729	COG0861	Integral membrane protein TerC family
Vapar_5738	COG0346	lactoylglutathione lyase activity
Vapar_5743	COG2159	amidohydrolase
Vapar_5744	COG0583	DNA-binding transcription factor activity
Vapar_5745	COG2084	Dehydrogenase
Vapar_5751	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_5752	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vapar_5754	COG0024	Methionine aminopeptidase
Vapar_5762	COG2207	Transcriptional regulator
Vapar_5769	COG2030	dehydratase
Vapar_5771	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5773	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_5774	COG1024	Enoyl-CoA hydratase
Vapar_5776	COG0183	Belongs to the thiolase family
Vapar_5789	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_5794	COG1289	transmembrane transporter activity
Vapar_5802	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vapar_5805	COG1522	sequence-specific DNA binding
Vapar_5806	COG0512	Glutamine amidotransferase of anthranilate synthase
Vapar_5806	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vapar_5808	COG3916	Acyl-homoserine-lactone synthase
Vapar_5810	COG4977	sequence-specific DNA binding
Vapar_5811	COG1475	DNA binding
Vapar_5816	COG3451	type IV secretory pathway VirB4
Vapar_5822	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Vapar_5830	COG3077	Addiction module antitoxin, RelB DinJ family
Vapar_5841	COG3459	Glycosyltransferase 36 associated
Vapar_5846	COG1126	abc transporter atp-binding protein
Vapar_5849	COG1484	DNA-dependent DNA replication
Vapar_5850	COG4584	PFAM Integrase catalytic
Vapar_5854	COG1196	nuclear chromosome segregation
Vapar_5871	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_5873	COG0183	Belongs to the thiolase family
Vapar_5874	COG1024	Enoyl-CoA hydratase
Vapar_5874	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vapar_5876	COG1024	Enoyl-CoA hydratase
Vapar_5882	COG0583	DNA-binding transcription factor activity
Vapar_5885	COG1473	amidohydrolase
Vapar_5886	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_5888	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vapar_5889	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_5890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Vapar_5893	COG0583	DNA-binding transcription factor activity
Vapar_5897	COG4654	Cytochrome c, class I
Vapar_5917	COG3550	peptidyl-serine autophosphorylation
Vapar_5928	COG1309	transcriptional regulator
Vapar_5936	COG3550	peptidyl-serine autophosphorylation
Vapar_5938	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vapar_5948	COG4172	Belongs to the ABC transporter superfamily
Vapar_5953	COG0583	DNA-binding transcription factor activity
Vapar_5957	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vapar_5963	COG0523	cobalamin synthesis protein
Vapar_5967	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vapar_5968	COG0583	DNA-binding transcription factor activity
Vapar_5975	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vapar_5976	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_5982	COG2433	Pfam Transposase IS66
Vapar_5992	COG2205	protein histidine kinase activity
Vapar_6002	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Vapar_6007	COG0444	Belongs to the ABC transporter superfamily
Vapar_6009	COG0601	transmembrane transport
Vapar_6013	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vapar_6015	COG0417	DNA replication proofreading
Vapar_6017	COG3447	MASE1 domain protein
Vapar_6017	COG5002	protein histidine kinase activity
Vapar_6017	COG5001	Diguanylate cyclase
Vapar_6024	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Vapar_6028	COG3386	PFAM SMP-30 Gluconolaconase
Vapar_6029	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_6031	COG3734	2-keto-3-deoxy-galactonokinase
Vapar_6032	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_6033	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_6037	COG0667	Aldo Keto reductase
Vapar_6042	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Vapar_6043	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Vapar_6044	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Vapar_6045	COG1335	isochorismatase
Vapar_6046	COG1942	4-Oxalocrotonate Tautomerase
Vapar_6051	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Vapar_6052	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vapar_6054	COG1802	Transcriptional regulator
Vapar_6056	COG0523	cobalamin synthesis protein
Vapar_6058	COG0402	S-adenosylhomocysteine deaminase activity
Vapar_6060	COG4948	Mandelate Racemase Muconate Lactonizing
Vapar_6063	COG1228	amidohydrolase
Vapar_6064	COG0596	Alpha beta hydrolase
Vapar_6065	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vapar_6071	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vapar_6072	COG0583	DNA-binding transcription factor activity
Vapar_6080	COG1309	transcriptional regulator
Vapar_6082	COG0604	alcohol dehydrogenase
Vapar_6084	COG2267	carboxylic ester hydrolase activity
Vapar_6086	COG3550	peptidyl-serine autophosphorylation
Vapar_6088	COG4133	protoheme IX ABC transporter activity
Vapar_6089	COG3639	organic phosphonate transmembrane transporter activity
Vapar_6090	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Vapar_6091	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Vapar_6092	COG3454	Phosphonate metabolism
Vapar_6093	COG4778	phosphonate C-P lyase system protein PhnL
Vapar_6094	COG4107	phosphonate C-P lyase system protein PhnK
Vapar_6095	COG3627	carbon phosphorus lyase activity
Vapar_6096	COG3626	phosphonate metabolism
Vapar_6098	COG3624	Phosphonate C-P lyase system protein PhnG
Vapar_6099	COG1609	Transcriptional regulator
Vapar_6100	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Vapar_6101	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Vapar_6103	COG4191	Histidine kinase
Vapar_6105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vapar_6108	COG1192	Involved in chromosome partitioning
Vapar_6109	COG1475	DNA binding
Vapar_6114	COG0583	DNA-binding transcription factor activity
Vapar_6120	COG2205	protein histidine kinase activity
Vapar_6126	COG0583	DNA-binding transcription factor activity
Vapar_6130	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_6134	COG1137	ATPase activity
Vapar_6138	COG3485	protocatechuate 3,4-dioxygenase
Vapar_6141	COG1609	Transcriptional regulator
Vapar_6143	COG1070	Carbohydrate kinase
Vapar_6144	COG2207	Transcriptional regulator
Vapar_6146	COG1024	Enoyl-CoA hydratase
Vapar_6148	COG2079	MmgE PrpD family protein
Vapar_6151	COG0583	DNA-binding transcription factor activity
Vapar_6160	COG3447	MASE1 domain protein
Vapar_6160	COG5001	Diguanylate cyclase
Vapar_6160	COG5002	protein histidine kinase activity
Vapar_6161	COG0596	Alpha beta hydrolase
Vapar_6169	COG4566	intracellular signal transduction
Vapar_6170	COG4191	Histidine kinase
Vapar_6174	COG3321	synthase
Vapar_6174	COG1028	Short-chain dehydrogenase reductase Sdr
Vapar_6174	COG0604	alcohol dehydrogenase
Vapar_6177	COG1024	Enoyl-CoA hydratase
Vapar_6179	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_6182	COG0583	DNA-binding transcription factor activity
Vapar_6187	COG2706	6-phosphogluconolactonase activity
Vapar_6191	COG0583	DNA-binding transcription factor activity
Vapar_6200	COG2814	Major facilitator Superfamily
Vapar_6201	COG0596	Alpha beta hydrolase
Vapar_6203	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Vapar_6204	COG1309	transcriptional regulator
Vapar_6205	COG4221	oxidoreductase activity
Vapar_6206	COG0604	alcohol dehydrogenase
Vapar_6214	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vapar_6221	COG0318	PFAM AMP-dependent synthetase and ligase
Vapar_6224	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Vapar_6230	COG0714	Associated with various cellular activities
Vapar_6231	COG3831	ATPase activity
Vapar_6233	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Vapar_6246	COG3901	Regulator of nitric oxide reductase transcription
Vapar_6246	COG0348	domain, Protein
Vapar_6247	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Vapar_6251	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vapar_6260	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_6261	COG0129	dihydroxy-acid dehydratase activity
Vapar_6264	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vapar_6267	COG0395	ABC-type sugar transport system, permease component
Vapar_6268	COG3842	ATPase activity
Vapar_6270	COG0596	Alpha beta hydrolase
Vapar_6283	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Vapar_6284	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vapar_6284	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vapar_6285	COG1051	belongs to the nudix hydrolase family
Vapar_6285	COG1056	cytidyltransferase-related domain
Vapar_6286	COG1397	ADP-ribosylglycohydrolase
Vapar_6290	COG0861	Integral membrane protein TerC family
Vapar_6295	COG0514	ATP-dependent DNA helicase (RecQ)
Vapar_6297	COG2832	Protein of unknown function (DUF454)
Vapar_6299	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vapar_6300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vapar_6303	COG2133	pyrroloquinoline quinone binding
Vapar_6305	COG3220	belongs to the UPF0276 family
Vapar_6310	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_6311	COG0477	Major facilitator Superfamily
Vapar_6312	COG3657	addiction module killer protein
Vapar_6313	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Vapar_6314	COG4221	oxidoreductase activity
Vapar_6315	COG1595	DNA-templated transcription, initiation
Vapar_6323	COG3604	Transcriptional regulator
Vapar_6327	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vapar_6328	COG1012	belongs to the aldehyde dehydrogenase family
Vapar_6330	COG0517	IMP dehydrogenase activity
Vapar_6331	COG0693	protein deglycase activity
Vapar_6345	COG3181	Tripartite tricarboxylate transporter family receptor
Vapar_6349	COG1462	curli production assembly transport component CsgG
Vapar_6351	COG3210	domain, Protein
Vapar_6356	COG2831	hemolysin activation secretion protein
Vapar_6359	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vapar_6362	COG0511	ligase activity, forming carbon-carbon bonds
Vapar_6364	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Vapar_6365	COG1984	allophanate hydrolase subunit 2
Vapar_6367	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Vapar_6368	COG4221	oxidoreductase activity
Vapar_6369	COG0765	amino acid transport
Vapar_6370	COG0765	amino acid transport
Vapar_6379	COG2070	2-Nitropropane dioxygenase