locus-tag	class	description
IG196_00005	COG2080	2 iron, 2 sulfur cluster binding
IG196_00010	COG2010	Cytochrome c
IG196_00010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_00150	COG0347	Belongs to the P(II) protein family
IG196_00155	COG0004	ammonium transporteR
IG196_00165	COG0583	DNA-binding transcription factor activity
IG196_00170	COG1620	l-lactate permease
IG196_00175	COG0277	FAD linked oxidase domain protein
IG196_00180	COG0277	FAD linked oxidase domain protein
IG196_00185	COG0247	lactate metabolic process
IG196_00195	COG0386	Belongs to the glutathione peroxidase family
IG196_00205	COG0477	Major facilitator Superfamily
IG196_00210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IG196_00230	COG0217	transcriptional regulatory protein
IG196_00245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_00260	COG0129	dihydroxy-acid dehydratase activity
IG196_00270	COG3971	2-oxopent-4-enoate hydratase activity
IG196_00290	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_00295	COG1012	belongs to the aldehyde dehydrogenase family
IG196_00315	COG1846	Transcriptional regulator
IG196_00330	COG0583	DNA-binding transcription factor activity
IG196_00340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IG196_00360	COG2974	May be involved in recombination
IG196_00390	COG0745	RESPONSE REGULATOR receiver
IG196_00400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IG196_00405	COG2211	Major facilitator Superfamily
IG196_00430	COG0708	Exodeoxyribonuclease III
IG196_00435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IG196_00445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG196_00450	COG0154	amidase activity
IG196_00455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG196_00460	COG1077	Cell shape determining protein MreB Mrl
IG196_00465	COG1792	Involved in formation and maintenance of cell shape
IG196_00475	COG0768	penicillin binding
IG196_00480	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_00490	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IG196_00500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_00515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IG196_00540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IG196_00545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IG196_00550	COG0583	DNA-binding transcription factor activity
IG196_00590	COG0436	Aminotransferase
IG196_00595	COG0028	Belongs to the TPP enzyme family
IG196_00605	COG0004	ammonium transporteR
IG196_00625	COG0724	RNA recognition motif
IG196_00635	COG0023	Translation Initiation Factor
IG196_00640	COG0513	Belongs to the DEAD box helicase family
IG196_00645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_00650	COG2272	Belongs to the type-B carboxylesterase lipase family
IG196_00665	COG0330	HflC and HflK could
IG196_00670	COG1960	acyl-CoA dehydrogenase activity
IG196_00675	COG1960	acyl-CoA dehydrogenase activity
IG196_00680	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_00685	COG0439	Biotin carboxylase
IG196_00690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG196_00705	COG2733	membrane
IG196_00720	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_00725	COG1473	amidohydrolase
IG196_00740	COG0243	molybdopterin cofactor binding
IG196_00755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_00785	COG0583	DNA-binding transcription factor activity
IG196_00800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_00810	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG196_00825	COG1946	Acyl-CoA thioesterase
IG196_00840	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_00845	COG0659	secondary active sulfate transmembrane transporter activity
IG196_00890	COG0667	Aldo Keto reductase
IG196_00895	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_00910	COG1070	Carbohydrate kinase
IG196_00915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IG196_00920	COG2188	Transcriptional regulator
IG196_00935	COG0629	single-stranded DNA binding
IG196_00965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_00970	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_00975	COG0482	sulfurtransferase activity
IG196_00995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IG196_01010	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_01015	COG0601	transmembrane transport
IG196_01020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_01025	COG0444	Belongs to the ABC transporter superfamily
IG196_01030	COG4608	Belongs to the ABC transporter superfamily
IG196_01035	COG0747	negative chemotaxis
IG196_01060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IG196_01070	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IG196_01075	COG0735	belongs to the Fur family
IG196_01080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_01085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IG196_01100	COG0058	SHG alpha-glucan phosphorylase activity
IG196_01105	COG0297	glycogen (starch) synthase activity
IG196_01110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IG196_01125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG196_01130	COG0366	Alpha amylase catalytic
IG196_01135	COG2072	flavoprotein involved in K transport
IG196_01140	COG0495	leucyl-tRNA aminoacylation
IG196_01155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IG196_01165	COG3158	transport of potassium into the cell
IG196_01170	COG3135	benzoate transporter
IG196_01175	COG0189	ligase activity
IG196_01190	COG0121	glutamine amidotransferase
IG196_01200	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_01205	COG0154	amidase activity
IG196_01225	COG2814	Major facilitator Superfamily
IG196_01240	COG0205	6-phosphofructokinase activity
IG196_01255	COG0583	DNA-binding transcription factor activity
IG196_01260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IG196_01275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG196_01280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_01285	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_01290	COG1414	Transcriptional regulator
IG196_01295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_01300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_01320	COG0018	arginyl-trna synthetase
IG196_01330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IG196_01335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IG196_01340	COG1137	ATPase activity
IG196_01345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IG196_01350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_01355	COG1280	lysine exporter protein (LysE YggA)
IG196_01365	COG2353	YceI-like domain
IG196_01370	COG3038	cytochrome b561
IG196_01405	COG0069	glutamate synthase activity
IG196_01435	COG2197	response regulator
IG196_01450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IG196_01460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_01465	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_01495	COG1335	isochorismatase
IG196_01500	COG4977	sequence-specific DNA binding
IG196_01505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IG196_01520	COG2967	ApaG domain
IG196_01525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IG196_01545	COG0693	protein deglycase activity
IG196_01545	COG0753	catalase activity
IG196_01560	COG3210	domain, Protein
IG196_01580	COG5002	protein histidine kinase activity
IG196_01595	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_01600	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_01630	COG0515	serine threonine protein kinase
IG196_01765	COG0546	phosphoglycolate phosphatase activity
IG196_01795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IG196_01800	COG0134	indole-3-glycerol-phosphate synthase activity
IG196_01805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IG196_01825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG196_01835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IG196_01845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IG196_01850	COG0081	regulation of translation
IG196_01855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IG196_01860	COG0222	ribosome binding
IG196_01865	COG0085	RNA polymerase activity
IG196_01870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IG196_01880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IG196_01880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG196_01890	COG5000	phosphorelay sensor kinase activity
IG196_01895	COG2204	response regulator
IG196_01945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IG196_01960	COG0210	DNA helicase
IG196_01965	COG0679	Auxin Efflux Carrier
IG196_01985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IG196_01990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IG196_02005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_02010	COG4232	protein-disulfide reductase activity
IG196_02015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG196_02025	COG1609	Transcriptional regulator
IG196_02055	COG0583	DNA-binding transcription factor activity
IG196_02060	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_02070	COG1215	transferase activity, transferring glycosyl groups
IG196_02075	COG1649	PFAM Uncharacterised BCR, COG1649
IG196_02075	COG0726	polysaccharide deacetylase
IG196_02090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_02095	COG1280	lysine exporter protein (LysE YggA)
IG196_02105	COG0384	phenazine biosynthesis protein PhzF
IG196_02110	COG0625	glutathione transferase activity
IG196_02115	COG0384	phenazine biosynthesis protein PhzF
IG196_02130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_02140	COG0697	spore germination
IG196_02170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_02215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IG196_02235	COG3959	Transketolase, thiamine diphosphate binding domain
IG196_02240	COG3958	Transketolase
IG196_02250	COG0463	Glycosyl transferase, family 2
IG196_02280	COG0463	Glycosyl transferase, family 2
IG196_02290	COG2755	lipolytic protein G-D-S-L family
IG196_02290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG196_02300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG196_02305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IG196_02310	COG1309	transcriptional regulator
IG196_02320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IG196_02325	COG2721	sulfolactate sulfo-lyase activity
IG196_02330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_02340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_02345	COG2186	Transcriptional regulator
IG196_02350	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_02355	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_02360	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_02365	COG0583	DNA-binding transcription factor activity
IG196_02370	COG4221	oxidoreductase activity
IG196_02380	COG1960	acyl-CoA dehydrogenase activity
IG196_02390	COG1024	Enoyl-CoA hydratase
IG196_02390	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_02395	COG0183	Belongs to the thiolase family
IG196_02415	COG1024	Enoyl-CoA hydratase
IG196_02420	COG0683	leucine binding
IG196_02430	COG5265	(ABC) transporter
IG196_02435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG196_02445	COG3712	iron ion homeostasis
IG196_02450	COG1595	DNA-templated transcription, initiation
IG196_02455	COG0154	amidase activity
IG196_02460	COG0583	DNA-binding transcription factor activity
IG196_02465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_02470	COG0765	amino acid transport
IG196_02475	COG0765	amino acid transport
IG196_02480	COG1126	abc transporter atp-binding protein
IG196_02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_02500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_02500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_02505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_02510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG196_02515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_02565	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_02575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_02580	COG1024	Enoyl-CoA hydratase
IG196_02585	COG1960	acyl-CoA dehydrogenase activity
IG196_02590	COG1960	acyl-CoA dehydrogenase activity
IG196_02595	COG0183	Belongs to the thiolase family
IG196_02600	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_02600	COG1024	Enoyl-CoA hydratase
IG196_02605	COG0583	DNA-binding transcription factor activity
IG196_02615	COG0154	amidase activity
IG196_02620	COG0444	Belongs to the ABC transporter superfamily
IG196_02625	COG4608	Belongs to the ABC transporter superfamily
IG196_02630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_02640	COG0747	negative chemotaxis
IG196_02665	COG1595	DNA-templated transcription, initiation
IG196_02670	COG0418	dihydroorotase activity
IG196_02690	COG0501	Belongs to the peptidase M48B family
IG196_02700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG196_02705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IG196_02710	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IG196_02725	COG3604	Transcriptional regulator
IG196_02755	COG1566	PFAM secretion protein HlyD family protein
IG196_02770	COG1187	pseudouridine synthase activity
IG196_02775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG196_02780	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_02805	COG2807	transmembrane transport
IG196_02810	COG0590	tRNA wobble adenosine to inosine editing
IG196_02830	COG0656	L-ascorbic acid biosynthetic process
IG196_02835	COG2814	Major facilitator Superfamily
IG196_02855	COG0583	DNA-binding transcription factor activity
IG196_02860	COG1335	isochorismatase
IG196_02895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IG196_02910	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IG196_02920	COG0523	cobalamin synthesis protein
IG196_02940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IG196_02945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IG196_02950	COG2001	Belongs to the MraZ family
IG196_02955	COG0275	rRNA processing
IG196_02970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG196_02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IG196_02980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG196_02985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IG196_02990	COG0772	Belongs to the SEDS family
IG196_02995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IG196_03000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG196_03005	COG1181	Belongs to the D-alanine--D-alanine ligase family
IG196_03010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IG196_03025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IG196_03035	COG0583	DNA-binding transcription factor activity
IG196_03040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG196_03045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IG196_03055	COG0575	Belongs to the CDS family
IG196_03075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG196_03090	COG3150	esterase
IG196_03095	COG2197	response regulator
IG196_03105	COG0772	Belongs to the SEDS family
IG196_03110	COG0312	modulator of DNA gyrase
IG196_03120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IG196_03130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG196_03140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_03145	COG0511	ligase activity, forming carbon-carbon bonds
IG196_03150	COG0439	Biotin carboxylase
IG196_03155	COG2264	protein methyltransferase activity
IG196_03165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG196_03175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG196_03205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG196_03210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IG196_03235	COG2204	response regulator
IG196_03245	COG2205	protein histidine kinase activity
IG196_03250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG196_03260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_03285	COG0037	tRNA processing
IG196_03295	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_03305	COG2175	clavaminate synthase activity
IG196_03315	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IG196_03320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_03340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_03350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_03360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_03375	COG0583	DNA-binding transcription factor activity
IG196_03380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IG196_03385	COG0739	heme binding
IG196_03385	COG1196	nuclear chromosome segregation
IG196_03385	COG0741	lytic transglycosylase activity
IG196_03405	COG0617	tRNA 3'-terminal CCA addition
IG196_03415	COG3387	PFAM Glycoside hydrolase 15-related
IG196_03420	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IG196_03455	COG2205	protein histidine kinase activity
IG196_03475	COG2832	Protein of unknown function (DUF454)
IG196_03485	COG5295	Hep Hag repeat protein
IG196_03495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IG196_03495	COG0506	proline dehydrogenase activity
IG196_03495	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IG196_03515	COG0697	spore germination
IG196_03520	COG0583	DNA-binding transcription factor activity
IG196_03525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IG196_03540	COG3386	PFAM SMP-30 Gluconolaconase
IG196_03545	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_03555	COG1012	belongs to the aldehyde dehydrogenase family
IG196_03560	COG1879	ABC-type sugar transport system periplasmic component
IG196_03565	COG4213	ABC transporter substrate-binding protein
IG196_03575	COG4214	carbohydrate transport
IG196_03580	COG1129	ABC transporter
IG196_03585	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_03590	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_03620	COG0189	ligase activity
IG196_03620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG196_03625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG196_03625	COG0189	ligase activity
IG196_03630	COG1132	(ABC) transporter
IG196_03640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IG196_03645	COG4178	(ABC) transporter
IG196_03650	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_03655	COG3842	ATPase activity
IG196_03660	COG4149	molybdate abc transporter
IG196_03675	COG2271	Major facilitator Superfamily
IG196_03690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_03700	COG2863	cytochrome
IG196_03715	COG2233	PERMEase
IG196_03720	COG0583	DNA-binding transcription factor activity
IG196_03805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_03810	COG1765	OsmC-like protein
IG196_03815	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IG196_03830	COG1473	amidohydrolase
IG196_03840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_03845	COG0444	Belongs to the ABC transporter superfamily
IG196_03850	COG4608	Belongs to the ABC transporter superfamily
IG196_03865	COG3384	dioxygenase
IG196_03870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IG196_03875	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_03900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IG196_03905	COG0166	Belongs to the GPI family
IG196_03935	COG1175	transmembrane transport
IG196_03940	COG0395	ABC-type sugar transport system, permease component
IG196_03950	COG0246	Mannitol dehydrogenase
IG196_03960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IG196_03970	COG2207	Transcriptional regulator
IG196_03970	COG4753	response regulator
IG196_03975	COG1070	Carbohydrate kinase
IG196_03980	COG0459	protein refolding
IG196_03985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IG196_03990	COG1595	DNA-templated transcription, initiation
IG196_03995	COG3712	iron ion homeostasis
IG196_04000	COG4774	siderophore transport
IG196_04025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_04030	COG4774	siderophore transport
IG196_04045	COG4772	TonB-dependent receptor
IG196_04050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IG196_04060	COG1560	Kdo2-lipid A biosynthetic process
IG196_04070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IG196_04080	COG1333	cytochrome c biogenesis protein
IG196_04085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG196_04090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG196_04095	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IG196_04100	COG0019	diaminopimelate decarboxylase activity
IG196_04110	COG1965	Belongs to the frataxin family
IG196_04145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG196_04150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IG196_04155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IG196_04180	COG0070	glutamate synthase
IG196_04180	COG0067	glutamate synthase
IG196_04180	COG0069	glutamate synthase activity
IG196_04190	COG1127	ABC transporter
IG196_04195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IG196_04200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IG196_04205	COG2853	Lipoprotein
IG196_04225	COG1131	(ABC) transporter
IG196_04230	COG0842	Transport permease protein
IG196_04235	COG5007	Belongs to the BolA IbaG family
IG196_04240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG196_04245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IG196_04265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_04270	COG0131	Imidazoleglycerol-phosphate dehydratase
IG196_04280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IG196_04285	COG2814	Major facilitator Superfamily
IG196_04290	COG0583	DNA-binding transcription factor activity
IG196_04300	COG1301	dicarboxylic acid transport
IG196_04310	COG0107	imidazoleglycerol-phosphate synthase activity
IG196_04315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IG196_04320	COG0140	phosphoribosyl-ATP diphosphatase activity
IG196_04330	COG0537	adenosine 5'-monophosphoramidase activity
IG196_04335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG196_04340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG196_04345	COG0805	protein transport
IG196_04360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IG196_04365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IG196_04370	COG1970	mechanosensitive ion channel activity
IG196_04375	COG1596	polysaccharide export
IG196_04380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IG196_04420	COG1086	Polysaccharide biosynthesis protein
IG196_04445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IG196_04460	COG0489	protein tyrosine kinase activity
IG196_04460	COG3206	protein involved in exopolysaccharide biosynthesis
IG196_04465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG196_04475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_04490	COG0723	plastoquinol--plastocyanin reductase activity
IG196_04495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IG196_04500	COG2857	Cytochrome c1
IG196_04505	COG0625	glutathione transferase activity
IG196_04510	COG2969	positive regulation of protein catabolic process
IG196_04530	COG1850	ribulose-bisphosphate carboxylase activity
IG196_04540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_04545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_04550	COG1609	Transcriptional regulator
IG196_04650	COG1595	DNA-templated transcription, initiation
IG196_04670	COG2226	methyltransferase
IG196_04685	COG2824	Alkylphosphonate utilization operon protein PhnA
IG196_04700	COG0640	Transcriptional regulator
IG196_04725	COG0798	PFAM Bile acid sodium symporter
IG196_04745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_04750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_04790	COG1595	DNA-templated transcription, initiation
IG196_04805	COG1595	DNA-templated transcription, initiation
IG196_04815	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_04825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IG196_04835	COG4591	ABC-type transport system involved in lipoprotein release permease component
IG196_04840	COG1136	(ABC) transporter
IG196_04870	COG0740	serine-type endopeptidase activity
IG196_04890	COG0601	transmembrane transport
IG196_04920	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_04975	COG1012	belongs to the aldehyde dehydrogenase family
IG196_05010	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IG196_05030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG196_05045	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_05050	COG2030	dehydratase
IG196_05050	COG1012	belongs to the aldehyde dehydrogenase family
IG196_05075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IG196_05080	COG2151	metal-sulfur cluster biosynthetic enzyme
IG196_05085	COG3396	Phenylacetate-CoA oxygenase
IG196_05090	COG3460	Phenylacetate-CoA oxygenase
IG196_05095	COG3396	Phenylacetate-CoA oxygenase
IG196_05105	COG2050	protein possibly involved in aromatic compounds catabolism
IG196_05110	COG1024	Enoyl-CoA hydratase
IG196_05120	COG1309	transcriptional regulator
IG196_05125	COG2304	oxidoreductase activity
IG196_05135	COG0714	Associated with various cellular activities
IG196_05140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_05145	COG0084	hydrolase, TatD family'
IG196_05160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_05165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IG196_05195	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_05215	COG0583	DNA-binding transcription factor activity
IG196_05230	COG1283	sodium-dependent phosphate transmembrane transporter activity
IG196_05235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IG196_05240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IG196_05260	COG1609	Transcriptional regulator
IG196_05275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IG196_05285	COG0196	riboflavin kinase activity
IG196_05295	COG1024	Enoyl-CoA hydratase
IG196_05310	COG1960	acyl-CoA dehydrogenase activity
IG196_05315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IG196_05335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IG196_05335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG196_05345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IG196_05350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IG196_05355	COG0492	ferredoxin-NADP+ reductase activity
IG196_05365	COG1674	ftsk spoiiie
IG196_05370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IG196_05375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IG196_05380	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_05450	COG2816	NAD+ diphosphatase activity
IG196_05455	COG0425	Belongs to the sulfur carrier protein TusA family
IG196_05465	COG0525	valine-tRNA ligase activity
IG196_05470	COG3022	response to hydroperoxide
IG196_05480	COG2267	carboxylic ester hydrolase activity
IG196_05485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IG196_05485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IG196_05490	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_05505	COG4948	Mandelate Racemase Muconate Lactonizing
IG196_05510	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_05525	COG1960	acyl-CoA dehydrogenase activity
IG196_05535	COG1960	acyl-CoA dehydrogenase activity
IG196_05545	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_05575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IG196_05605	COG1283	sodium-dependent phosphate transmembrane transporter activity
IG196_05610	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
IG196_05625	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_05630	COG0583	DNA-binding transcription factor activity
IG196_05635	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_05650	COG2186	Transcriptional regulator
IG196_05665	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_05680	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_05690	COG4948	Mandelate Racemase Muconate Lactonizing
IG196_05695	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_05700	COG3254	rhamnose metabolic process
IG196_05740	COG0583	DNA-binding transcription factor activity
IG196_05755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IG196_05760	COG4221	oxidoreductase activity
IG196_05790	COG4166	transmembrane transport
IG196_05795	COG0601	transmembrane transport
IG196_05805	COG4172	Belongs to the ABC transporter superfamily
IG196_05815	COG1473	amidohydrolase
IG196_05820	COG2807	transmembrane transport
IG196_05825	COG2186	Transcriptional regulator
IG196_05830	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IG196_05835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG196_05840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IG196_05860	COG1280	lysine exporter protein (LysE YggA)
IG196_05945	COG4566	intracellular signal transduction
IG196_05950	COG0477	Major facilitator Superfamily
IG196_05960	COG0165	Argininosuccinate lyase
IG196_05965	COG3275	phosphorelay sensor kinase activity
IG196_05985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG196_05990	COG2271	Major facilitator Superfamily
IG196_06000	COG0583	DNA-binding transcription factor activity
IG196_06015	COG3459	Glycosyltransferase 36 associated
IG196_06025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IG196_06030	COG0181	hydroxymethylbilane synthase activity
IG196_06035	COG1587	Uroporphyrinogen-III synthase
IG196_06055	COG0583	DNA-binding transcription factor activity
IG196_06060	COG1530	ribonuclease E activity
IG196_06080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IG196_06080	COG0616	signal peptide processing
IG196_06085	COG2223	nitrite transmembrane transporter activity
IG196_06090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IG196_06095	COG0424	maF-like protein
IG196_06105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IG196_06110	COG0416	fatty acid biosynthetic process
IG196_06115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG196_06125	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_06130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG196_06135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IG196_06160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_06165	COG0481	GTPase activity
IG196_06170	COG0681	Belongs to the peptidase S26 family
IG196_06180	COG0571	ribonuclease III activity
IG196_06185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IG196_06190	COG1381	Involved in DNA repair and RecF pathway recombination
IG196_06200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IG196_06205	COG0736	holo-[acyl-carrier-protein] synthase activity
IG196_06210	COG1472	Belongs to the glycosyl hydrolase 3 family
IG196_06220	COG1451	nucleotide metabolic process
IG196_06225	COG0443	Heat shock 70 kDa protein
IG196_06240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IG196_06255	COG0762	integral membrane protein
IG196_06260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IG196_06265	COG0159	tryptophan synthase activity
IG196_06270	COG0133	tryptophan synthase activity
IG196_06275	COG0135	phosphoribosylanthranilate isomerase activity
IG196_06280	COG0101	tRNA pseudouridine synthase activity
IG196_06290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IG196_06295	COG0473	3-isopropylmalate dehydrogenase activity
IG196_06300	COG0066	3-isopropylmalate dehydratase activity
IG196_06305	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IG196_06315	COG0372	Belongs to the citrate synthase family
IG196_06320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IG196_06325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IG196_06330	COG1053	succinate dehydrogenase
IG196_06345	COG2188	Transcriptional regulator
IG196_06350	COG0039	L-malate dehydrogenase activity
IG196_06355	COG4106	trans-aconitate 2-methyltransferase activity
IG196_06370	COG1049	propionate catabolic process, 2-methylcitrate cycle
IG196_06425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IG196_06435	COG0672	)-iron permease
IG196_06440	COG2822	iron ion transport
IG196_06450	COG2822	iron ion transport
IG196_06460	COG1918	ferrous iron import across plasma membrane
IG196_06460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IG196_06470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_06485	COG0628	permease
IG196_06495	COG1301	dicarboxylic acid transport
IG196_06535	COG0583	DNA-binding transcription factor activity
IG196_06590	COG0366	Alpha amylase catalytic
IG196_06595	COG1942	4-Oxalocrotonate Tautomerase
IG196_06610	COG0284	orotidine-5'-phosphate decarboxylase activity
IG196_06645	COG0154	amidase activity
IG196_06655	COG4608	Belongs to the ABC transporter superfamily
IG196_06660	COG0444	Belongs to the ABC transporter superfamily
IG196_06665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_06675	COG0473	3-isopropylmalate dehydrogenase activity
IG196_06680	COG0656	L-ascorbic acid biosynthetic process
IG196_06685	COG2233	PERMEase
IG196_06700	COG1309	transcriptional regulator
IG196_06715	COG1953	Uracil, thiamine, allantoin
IG196_06730	COG4774	siderophore transport
IG196_06755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_06770	COG2186	Transcriptional regulator
IG196_06775	COG2351	hydroxyisourate hydrolase activity
IG196_06830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG196_06860	COG0730	response to heat
IG196_06870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_06880	COG2252	PERMEase
IG196_06885	COG3845	ABC transporter
IG196_06920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG196_06925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IG196_06930	COG2814	Major facilitator Superfamily
IG196_06935	COG0583	DNA-binding transcription factor activity
IG196_06940	COG4977	sequence-specific DNA binding
IG196_06945	COG2366	antibiotic biosynthetic process
IG196_06960	COG0402	S-adenosylhomocysteine deaminase activity
IG196_06965	COG0717	Belongs to the dCTP deaminase family
IG196_06970	COG2321	neutral zinc metallopeptidase
IG196_06975	COG0513	Belongs to the DEAD box helicase family
IG196_06990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_06995	COG1960	acyl-CoA dehydrogenase activity
IG196_07005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_07015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_07020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_07025	COG1116	anion transmembrane transporter activity
IG196_07045	COG2197	response regulator
IG196_07065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IG196_07070	COG1253	flavin adenine dinucleotide binding
IG196_07080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IG196_07085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IG196_07120	COG0583	DNA-binding transcription factor activity
IG196_07140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG196_07155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG196_07160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IG196_07240	COG0516	GMP reductase activity
IG196_07245	COG3047	cAMP biosynthetic process
IG196_07250	COG0210	DNA helicase
IG196_07270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IG196_07290	COG0583	DNA-binding transcription factor activity
IG196_07295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG196_07305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG196_07320	COG4774	siderophore transport
IG196_07345	COG0412	Dienelactone hydrolase
IG196_07365	COG4172	Belongs to the ABC transporter superfamily
IG196_07370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_07375	COG0601	transmembrane transport
IG196_07380	COG4166	transmembrane transport
IG196_07390	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_07395	COG4608	Belongs to the ABC transporter superfamily
IG196_07400	COG0444	Belongs to the ABC transporter superfamily
IG196_07405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_07410	COG0601	transmembrane transport
IG196_07415	COG0747	negative chemotaxis
IG196_07445	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_07465	COG2030	dehydratase
IG196_07480	COG2079	MmgE PrpD family protein
IG196_07485	COG2301	Belongs to the HpcH HpaI aldolase family
IG196_07550	COG2226	methyltransferase
IG196_07560	COG3064	Membrane
IG196_07600	COG1722	exodeoxyribonuclease VII activity
IG196_07605	COG0142	geranyltranstransferase activity
IG196_07610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IG196_07615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IG196_07620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_07630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG196_07635	COG0477	Major facilitator Superfamily
IG196_07650	COG3842	ATPase activity
IG196_07655	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_07660	COG1802	Transcriptional regulator
IG196_07670	COG1012	belongs to the aldehyde dehydrogenase family
IG196_07680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_07700	COG2188	Transcriptional regulator
IG196_07710	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_07785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IG196_07785	COG3608	succinylglutamate desuccinylase aspartoacylase
IG196_07810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_07815	COG1309	transcriptional regulator
IG196_07825	COG1320	monovalent cation:proton antiporter activity
IG196_07830	COG2212	antiporter activity
IG196_07840	COG0651	ATP synthesis coupled electron transport
IG196_07845	COG1006	Multisubunit Na H antiporter MnhC subunit
IG196_07850	COG2111	Na H antiporter
IG196_07850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IG196_07855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG196_07860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_07860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_07870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_07880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IG196_07900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IG196_07905	COG0287	Prephenate dehydrogenase
IG196_07910	COG1605	Chorismate mutase
IG196_07910	COG0077	Prephenate dehydratase
IG196_07915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IG196_07935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG196_07955	COG0582	viral genome integration into host DNA
IG196_08060	COG5377	YqaJ viral recombinase family
IG196_08135	COG4569	acetaldehyde dehydrogenase (acetylating) activity
IG196_08140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_08155	COG0596	Alpha beta hydrolase
IG196_08190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG196_08190	COG2755	lipolytic protein G-D-S-L family
IG196_08200	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_08205	COG0583	DNA-binding transcription factor activity
IG196_08210	COG0753	catalase activity
IG196_08215	COG1764	response to oxidative stress
IG196_08220	COG2353	YceI-like domain
IG196_08255	COG0625	glutathione transferase activity
IG196_08280	COG1741	Belongs to the pirin family
IG196_08295	COG0625	glutathione transferase activity
IG196_08300	COG2807	transmembrane transport
IG196_08305	COG2207	Transcriptional regulator
IG196_08310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IG196_08325	COG1454	alcohol dehydrogenase
IG196_08330	COG0583	DNA-binding transcription factor activity
IG196_08335	COG0655	NAD(P)H dehydrogenase (quinone) activity
IG196_08340	COG0346	lactoylglutathione lyase activity
IG196_08350	COG3483	tryptophan 2,3-dioxygenase activity
IG196_08355	COG0154	amidase activity
IG196_08385	COG0583	DNA-binding transcription factor activity
IG196_08395	COG2205	protein histidine kinase activity
IG196_08415	COG2197	response regulator
IG196_08420	COG2197	response regulator
IG196_08455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG196_08465	COG1126	abc transporter atp-binding protein
IG196_08470	COG0765	amino acid transport
IG196_08475	COG0626	cystathionine gamma-synthase activity
IG196_08480	COG0583	DNA-binding transcription factor activity
IG196_08485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_08490	COG2205	protein histidine kinase activity
IG196_08500	COG0745	RESPONSE REGULATOR receiver
IG196_08530	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IG196_08535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IG196_08550	COG2205	protein histidine kinase activity
IG196_08635	COG0601	transmembrane transport
IG196_08640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_08645	COG0444	Belongs to the ABC transporter superfamily
IG196_08710	COG0534	Mate efflux family protein
IG196_08715	COG1538	Outer membrane efflux protein
IG196_08735	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_08740	COG0583	DNA-binding transcription factor activity
IG196_08755	COG0768	penicillin binding
IG196_08760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_08775	COG1595	DNA-templated transcription, initiation
IG196_08800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_08815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG196_08835	COG2132	Multicopper oxidase
IG196_08865	COG2197	response regulator
IG196_08870	COG2197	response regulator
IG196_08900	COG2271	Major facilitator Superfamily
IG196_08930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_08930	COG4797	methyltransferase
IG196_08965	COG1058	Belongs to the CinA family
IG196_08965	COG1546	Belongs to the CinA family
IG196_08970	COG0174	glutamine synthetase
IG196_08980	COG3852	Histidine kinase
IG196_08995	COG0708	Exodeoxyribonuclease III
IG196_09010	COG0303	'Molybdopterin
IG196_09015	COG0303	'Molybdopterin
IG196_09035	COG0437	4 iron, 4 sulfur cluster binding
IG196_09040	COG0243	molybdopterin cofactor binding
IG196_09040	COG3383	formate dehydrogenase (NAD+) activity
IG196_09070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG196_09075	COG0596	Alpha beta hydrolase
IG196_09085	COG1764	response to oxidative stress
IG196_09130	COG1012	belongs to the aldehyde dehydrogenase family
IG196_09150	COG1137	ATPase activity
IG196_09170	COG3485	protocatechuate 3,4-dioxygenase
IG196_09210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_09230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IG196_09235	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IG196_09245	COG0535	radical SAM domain protein
IG196_09260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_09265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_09270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IG196_09275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_09285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_09290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IG196_09315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IG196_09335	COG0277	FAD linked oxidase domain protein
IG196_09345	COG1295	ribonuclease BN
IG196_09355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_09365	COG2267	carboxylic ester hydrolase activity
IG196_09385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IG196_09390	COG0583	DNA-binding transcription factor activity
IG196_09410	COG1414	Transcriptional regulator
IG196_09415	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_09420	COG4638	Rieske (2fe-2S)
IG196_09465	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IG196_09475	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_09520	COG0431	NADPH-dependent FMN reductase
IG196_09535	COG0640	Transcriptional regulator
IG196_09550	COG3070	regulator of competence-specific genes
IG196_09555	COG0346	lactoylglutathione lyase activity
IG196_09565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_09580	COG0625	glutathione transferase activity
IG196_09600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IG196_09605	COG2719	SpoVR family
IG196_09610	COG2718	Belongs to the UPF0229 family
IG196_09615	COG2766	serine protein kinase
IG196_09620	COG0484	heat shock protein binding
IG196_09625	COG0443	Heat shock 70 kDa protein
IG196_09630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IG196_09645	COG0688	phosphatidylethanolamine metabolic process
IG196_09665	COG2721	sulfolactate sulfo-lyase activity
IG196_09670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_09680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_09690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_09695	COG2186	Transcriptional regulator
IG196_09700	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_09705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_09715	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_09730	COG1012	belongs to the aldehyde dehydrogenase family
IG196_09750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_09760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IG196_09770	COG1802	Transcriptional regulator
IG196_09805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_09825	COG0583	DNA-binding transcription factor activity
IG196_09830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_09835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_09850	COG2814	Major facilitator Superfamily
IG196_09865	COG1295	ribonuclease BN
IG196_09865	COG1959	2 iron, 2 sulfur cluster binding
IG196_09880	COG0123	including yeast histone deacetylase and acetoin utilization protein
IG196_09895	COG3237	CsbD-like
IG196_09900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IG196_09910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG196_09925	COG0477	Major facilitator Superfamily
IG196_09940	COG1611	Belongs to the LOG family
IG196_09945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IG196_09960	COG0405	Gamma-glutamyltransferase
IG196_09965	COG0322	excinuclease ABC activity
IG196_09970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IG196_09980	COG0583	DNA-binding transcription factor activity
IG196_09985	COG0596	Alpha beta hydrolase
IG196_09990	COG0473	3-isopropylmalate dehydrogenase activity
IG196_10005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG196_10040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IG196_10045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG196_10060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IG196_10065	COG0670	Belongs to the BI1 family
IG196_10070	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IG196_10100	COG3128	pkhd-type hydroxylase
IG196_10105	COG4774	siderophore transport
IG196_10110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG196_10115	COG1477	protein flavinylation
IG196_10150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IG196_10165	COG0360	Binds together with S18 to 16S ribosomal RNA
IG196_10170	COG2965	DNA replication, synthesis of RNA primer
IG196_10175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IG196_10180	COG0359	binds to the 23S rRNA
IG196_10185	COG0305	Participates in initiation and elongation during chromosome replication
IG196_10215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IG196_10220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IG196_10230	COG0436	Aminotransferase
IG196_10245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IG196_10250	COG1763	Mo-molybdopterin cofactor biosynthetic process
IG196_10255	COG0303	'Molybdopterin
IG196_10265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_10275	COG0314	molybdopterin synthase activity
IG196_10285	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_10290	COG0542	response to heat
IG196_10300	COG1022	Amp-dependent synthetase and ligase
IG196_10330	COG1309	transcriptional regulator
IG196_10335	COG1024	Enoyl-CoA hydratase
IG196_10340	COG0183	Belongs to the thiolase family
IG196_10365	COG0583	DNA-binding transcription factor activity
IG196_10385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG196_10400	COG2814	Major facilitator Superfamily
IG196_10410	COG0789	Transcriptional regulator
IG196_10425	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_10430	COG4974	Belongs to the 'phage' integrase family
IG196_10435	COG0583	DNA-binding transcription factor activity
IG196_10440	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_10445	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IG196_10465	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_10470	COG1309	transcriptional regulator
IG196_10475	COG0183	Belongs to the thiolase family
IG196_10490	COG2833	Protein of unknown function (DUF455)
IG196_10500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IG196_10510	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_10535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IG196_10540	COG0148	phosphopyruvate hydratase activity
IG196_10550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IG196_10555	COG0504	CTP synthase activity
IG196_10560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IG196_10570	COG0756	dUTP diphosphatase activity
IG196_10580	COG1047	Peptidyl-prolyl cis-trans
IG196_10585	COG2850	peptidyl-arginine hydroxylation
IG196_10600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IG196_10605	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IG196_10610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_10625	COG2814	Major facilitator Superfamily
IG196_10630	COG2814	Major facilitator Superfamily
IG196_10640	COG0583	DNA-binding transcription factor activity
IG196_10650	COG0741	lytic transglycosylase activity
IG196_10695	COG0765	amino acid transport
IG196_10700	COG0765	amino acid transport
IG196_10705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_10710	COG1126	abc transporter atp-binding protein
IG196_10720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG196_10730	COG1609	Transcriptional regulator
IG196_10740	COG2197	response regulator
IG196_10745	COG2957	Belongs to the agmatine deiminase family
IG196_10750	COG2957	Belongs to the agmatine deiminase family
IG196_10755	COG0583	DNA-binding transcription factor activity
IG196_10760	COG5002	protein histidine kinase activity
IG196_10775	COG1024	Enoyl-CoA hydratase
IG196_10790	COG1960	acyl-CoA dehydrogenase activity
IG196_10795	COG1960	acyl-CoA dehydrogenase activity
IG196_10810	COG2271	Major facilitator Superfamily
IG196_10840	COG2197	response regulator
IG196_10845	COG4585	Histidine kinase
IG196_10890	COG2308	Evidence 4 Homologs of previously reported genes of
IG196_10915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG196_10930	COG3842	ATPase activity
IG196_10945	COG0395	ABC-type sugar transport system, permease component
IG196_10965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG196_10980	COG1131	(ABC) transporter
IG196_11010	COG2951	lytic endotransglycosylase activity
IG196_11025	COG0714	Associated with various cellular activities
IG196_11035	COG3264	Mechanosensitive ion channel
IG196_11035	COG1196	nuclear chromosome segregation
IG196_11050	COG1960	acyl-CoA dehydrogenase activity
IG196_11065	COG4988	ABC transporter
IG196_11070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IG196_11075	COG1271	oxidase subunit
IG196_11080	COG1294	oxidase, subunit
IG196_11105	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_11115	COG2030	dehydratase
IG196_11125	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_11130	COG1024	Enoyl-CoA hydratase
IG196_11145	COG0640	Transcriptional regulator
IG196_11160	COG3795	YCII-related domain
IG196_11165	COG3795	YCII-related domain
IG196_11170	COG0477	Major facilitator Superfamily
IG196_11180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IG196_11190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IG196_11200	COG2985	domain, Protein
IG196_11205	COG2985	domain, Protein
IG196_11255	COG0642	Histidine kinase
IG196_11260	COG0745	RESPONSE REGULATOR receiver
IG196_11270	COG1414	Transcriptional regulator
IG196_11275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG196_11280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG196_11295	COG2814	Major facilitator Superfamily
IG196_11305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IG196_11305	COG1082	Xylose isomerase domain protein TIM barrel
IG196_11310	COG0477	Major facilitator Superfamily
IG196_11335	COG3148	PFAM DTW domain containing protein
IG196_11360	COG1473	amidohydrolase
IG196_11410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG196_11435	COG1309	transcriptional regulator
IG196_11455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG196_11455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG196_11460	COG0509	glycine decarboxylation via glycine cleavage system
IG196_11465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG196_11490	COG2207	Transcriptional regulator
IG196_11495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_11495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_11505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_11510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_11525	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_11535	COG0824	Thioesterase
IG196_11540	COG0642	Histidine kinase
IG196_11545	COG0745	RESPONSE REGULATOR receiver
IG196_11555	COG0671	phosphoesterase, PA-phosphatase related
IG196_11560	COG2194	sulfuric ester hydrolase activity
IG196_11570	COG4302	ethanolamine ammonia-lyase activity
IG196_11575	COG4303	Ethanolamine ammonia lyase large subunit
IG196_11580	COG0531	amino acid
IG196_11585	COG0545	Peptidyl-prolyl cis-trans isomerase
IG196_11595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IG196_11605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IG196_11635	COG3284	Transcriptional regulator
IG196_11640	COG1012	belongs to the aldehyde dehydrogenase family
IG196_11700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_11705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_11715	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_11725	COG0456	acetyltransferase
IG196_11745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_11775	COG1024	Enoyl-CoA hydratase
IG196_11790	COG0583	DNA-binding transcription factor activity
IG196_11795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IG196_11810	COG2818	Glycosylase
IG196_11815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_11845	COG1183	phosphatidylcholine synthase activity
IG196_11850	COG0519	Catalyzes the synthesis of GMP from XMP
IG196_11850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG196_11855	COG0583	DNA-binding transcription factor activity
IG196_11860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_11865	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_11880	COG0640	Transcriptional regulator
IG196_11890	COG0583	DNA-binding transcription factor activity
IG196_11895	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_11900	COG1960	acyl-CoA dehydrogenase activity
IG196_11910	COG1272	protein, Hemolysin III
IG196_11915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_11925	COG1024	Enoyl-CoA hydratase
IG196_11930	COG1160	GTP binding
IG196_11970	COG0583	DNA-binding transcription factor activity
IG196_11975	COG3384	dioxygenase
IG196_11995	COG0583	DNA-binding transcription factor activity
IG196_12020	COG0587	DNA-directed DNA polymerase activity
IG196_12050	COG0583	DNA-binding transcription factor activity
IG196_12100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_12105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IG196_12110	COG2080	2 iron, 2 sulfur cluster binding
IG196_12135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG196_12140	COG0366	Alpha amylase catalytic
IG196_12145	COG0366	Alpha amylase catalytic
IG196_12160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG196_12165	COG1640	4-alpha-glucanotransferase
IG196_12175	COG0517	IMP dehydrogenase activity
IG196_12210	COG2267	carboxylic ester hydrolase activity
IG196_12230	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_12275	COG0583	DNA-binding transcription factor activity
IG196_12315	COG0154	amidase activity
IG196_12330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IG196_12335	COG2271	Major facilitator Superfamily
IG196_12365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG196_12370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_12380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_12385	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_12405	COG1414	Transcriptional regulator
IG196_12410	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_12415	COG0028	Belongs to the TPP enzyme family
IG196_12420	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IG196_12425	COG1012	belongs to the aldehyde dehydrogenase family
IG196_12465	COG2271	Major facilitator Superfamily
IG196_12500	COG0583	DNA-binding transcription factor activity
IG196_12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_12520	COG3437	response regulator, receiver
IG196_12525	COG2205	protein histidine kinase activity
IG196_12525	COG2198	Histidine kinase
IG196_12525	COG0784	Response regulator, receiver
IG196_12545	COG3842	ATPase activity
IG196_12585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG196_12590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_12610	COG3976	FMN-binding domain protein
IG196_12610	COG1053	succinate dehydrogenase
IG196_12610	COG0431	NADPH-dependent FMN reductase
IG196_12635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_12655	COG0583	DNA-binding transcription factor activity
IG196_12660	COG0477	Major facilitator Superfamily
IG196_12665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IG196_12695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IG196_12700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG196_12705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IG196_12705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_12715	COG1741	Belongs to the pirin family
IG196_12720	COG2259	Doxx family
IG196_12730	COG1741	Belongs to the pirin family
IG196_12735	COG1054	Belongs to the UPF0176 family
IG196_12750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IG196_12750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IG196_12765	COG0848	biopolymer transport protein
IG196_12775	COG0824	Thioesterase
IG196_12780	COG0436	Aminotransferase
IG196_12785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG196_12790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG196_12805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG196_12805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG196_12810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IG196_12815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG196_12820	COG0741	lytic transglycosylase activity
IG196_12845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_12850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IG196_12865	COG0215	cysteine-tRNA ligase activity
IG196_12875	COG0825	malonyl-CoA metabolic process
IG196_12880	COG0037	tRNA processing
IG196_12885	COG0527	aspartate kinase activity
IG196_12925	COG4585	Histidine kinase
IG196_12950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_12985	COG2207	Transcriptional regulator
IG196_13005	COG2326	polyphosphate kinase activity
IG196_13015	COG0642	Histidine kinase
IG196_13025	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_13045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_13080	COG0411	ABC transporter
IG196_13110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG196_13115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IG196_13120	COG1011	Hydrolase
IG196_13130	COG1280	lysine exporter protein (LysE YggA)
IG196_13140	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IG196_13145	COG1562	ergosterol biosynthetic process
IG196_13155	COG3158	transport of potassium into the cell
IG196_13160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_13175	COG0544	peptidyl-prolyl cis-trans isomerase activity
IG196_13180	COG0740	serine-type endopeptidase activity
IG196_13185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IG196_13190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IG196_13240	COG2113	Glycine betaine
IG196_13245	COG4176	ABC-type proline glycine betaine transport system permease component
IG196_13250	COG4175	Glycine betaine
IG196_13255	COG0114	fumarate hydratase activity
IG196_13260	COG2910	NAD(P)H-binding
IG196_13265	COG0583	DNA-binding transcription factor activity
IG196_13275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG196_13285	COG4654	Cytochrome c, class I
IG196_13300	COG0129	dihydroxy-acid dehydratase activity
IG196_13305	COG0583	DNA-binding transcription factor activity
IG196_13310	COG0583	DNA-binding transcription factor activity
IG196_13325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IG196_13330	COG1802	Transcriptional regulator
IG196_13350	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_13365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG196_13380	COG0730	response to heat
IG196_13400	COG1797	cobyrinic acid a,c-diamide synthase activity
IG196_13410	COG4607	ABC-type enterochelin transport system periplasmic component
IG196_13415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG196_13420	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IG196_13425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IG196_13430	COG0778	Nitroreductase
IG196_13445	COG1429	ligase activity, forming nitrogen-metal bonds
IG196_13450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IG196_13455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_13465	COG1346	cytolysis
IG196_13490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_13500	COG1538	Outer membrane efflux protein
IG196_13520	COG1492	cobalamin metabolic process
IG196_13525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IG196_13530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IG196_13545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IG196_13550	COG3550	peptidyl-serine autophosphorylation
IG196_13560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_13580	COG0560	Phosphoserine phosphatase
IG196_13585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IG196_13590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IG196_13590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IG196_13595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IG196_13595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IG196_13620	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_13630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG196_13645	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IG196_13650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG196_13665	COG0557	exoribonuclease II activity
IG196_13670	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_13675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IG196_13675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IG196_13695	COG0052	Belongs to the universal ribosomal protein uS2 family
IG196_13700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IG196_13705	COG0528	UMP kinase activity
IG196_13710	COG0233	cytoplasmic translational termination
IG196_13715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IG196_13720	COG0575	Belongs to the CDS family
IG196_13725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IG196_13730	COG0750	zinc metalloprotease
IG196_13735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_13745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_13750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG196_13755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_13760	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_13770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG196_13775	COG0505	Belongs to the CarA family
IG196_13780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IG196_13790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG196_13805	COG1534	Rna-binding protein
IG196_13810	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IG196_13815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_13825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG196_13845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_13850	COG1024	Enoyl-CoA hydratase
IG196_13855	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_13865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_13875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IG196_13880	COG0252	asparaginase activity
IG196_13885	COG0563	adenylate kinase activity
IG196_13890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IG196_13895	COG2835	tetraacyldisaccharide 4'-kinase activity
IG196_13900	COG1663	tetraacyldisaccharide 4'-kinase activity
IG196_13905	COG0848	biopolymer transport protein
IG196_13910	COG0811	peptide transport
IG196_13915	COG1570	exodeoxyribonuclease VII activity
IG196_13970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IG196_13975	COG0542	response to heat
IG196_13980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_13985	COG2925	Exonuclease
IG196_14010	COG4191	Histidine kinase
IG196_14015	COG4566	intracellular signal transduction
IG196_14030	COG2808	Putative FMN-binding domain
IG196_14045	COG1619	proteins homologs of microcin C7 resistance protein MccF
IG196_14075	COG5002	protein histidine kinase activity
IG196_14085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IG196_14090	COG4999	Histidine kinase
IG196_14090	COG3850	Histidine kinase
IG196_14090	COG3437	response regulator, receiver
IG196_14090	COG2205	protein histidine kinase activity
IG196_14120	COG0156	8-amino-7-oxononanoate synthase activity
IG196_14125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IG196_14130	COG0667	Aldo Keto reductase
IG196_14135	COG2207	Transcriptional regulator
IG196_14140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_14145	COG3360	Dodecin
IG196_14155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_14160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_14165	COG1473	amidohydrolase
IG196_14175	COG1126	abc transporter atp-binding protein
IG196_14180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_14190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_14210	COG0601	transmembrane transport
IG196_14215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_14240	COG0045	succinate-CoA ligase (ADP-forming) activity
IG196_14240	COG1042	CoA-binding domain protein
IG196_14240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IG196_14250	COG2258	MOSC domain
IG196_14265	COG2207	Transcriptional regulator
IG196_14270	COG1473	amidohydrolase
IG196_14275	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_14285	COG0583	DNA-binding transcription factor activity
IG196_14300	COG2351	hydroxyisourate hydrolase activity
IG196_14305	COG2351	hydroxyisourate hydrolase activity
IG196_14310	COG0590	tRNA wobble adenosine to inosine editing
IG196_14320	COG0251	oxidation-reduction process
IG196_14325	COG2801	Transposase and inactivated derivatives
IG196_14335	COG0666	response to abiotic stimulus
IG196_14340	COG0084	hydrolase, TatD family'
IG196_14355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IG196_14360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IG196_14435	COG2183	response to ionizing radiation
IG196_14440	COG4585	Histidine kinase
IG196_14445	COG2201	protein-glutamate methylesterase activity
IG196_14485	COG0534	Mate efflux family protein
IG196_14500	COG4774	siderophore transport
IG196_14505	COG3712	iron ion homeostasis
IG196_14510	COG1595	DNA-templated transcription, initiation
IG196_14525	COG0477	Major facilitator Superfamily
IG196_14535	COG3008	intermembrane lipid transfer
IG196_14535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IG196_14540	COG2995	paraquat-inducible protein a
IG196_14545	COG2995	paraquat-inducible protein a
IG196_14550	COG2814	Major facilitator Superfamily
IG196_14555	COG2814	Major facilitator Superfamily
IG196_14570	COG0583	DNA-binding transcription factor activity
IG196_14580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IG196_14615	COG0277	FAD linked oxidase domain protein
IG196_14615	COG0247	lactate metabolic process
IG196_14620	COG1802	Transcriptional regulator
IG196_14640	COG0583	DNA-binding transcription factor activity
IG196_14645	COG2814	Major facilitator Superfamily
IG196_14665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IG196_14670	COG0583	DNA-binding transcription factor activity
IG196_14690	COG1960	acyl-CoA dehydrogenase activity
IG196_14695	COG2130	NADP-dependent
IG196_14725	COG1960	acyl-CoA dehydrogenase activity
IG196_14735	COG0183	Belongs to the thiolase family
IG196_14745	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_14745	COG1024	Enoyl-CoA hydratase
IG196_14755	COG0411	ABC transporter
IG196_14765	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_14780	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_14785	COG2272	Belongs to the type-B carboxylesterase lipase family
IG196_14795	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IG196_14800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG196_14805	COG2917	probably involved in intracellular septation
IG196_14815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG196_14840	COG0047	phosphoribosylformylglycinamidine synthase activity
IG196_14840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IG196_14845	COG0024	Methionine aminopeptidase
IG196_14850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IG196_14875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_14880	COG0765	amino acid transport
IG196_14885	COG4597	amino acid ABC transporter
IG196_14890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_14900	COG0242	peptide deformylase activity
IG196_14910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IG196_14920	COG1196	nuclear chromosome segregation
IG196_14935	COG3550	peptidyl-serine autophosphorylation
IG196_14985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG196_15000	COG0433	COG0433 Predicted ATPase
IG196_15010	COG1595	DNA-templated transcription, initiation
IG196_15035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IG196_15040	COG1744	ABC transporter substrate-binding protein PnrA-like
IG196_15050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IG196_15060	COG3845	ABC transporter
IG196_15065	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG196_15070	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG196_15080	COG0402	S-adenosylhomocysteine deaminase activity
IG196_15100	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_15140	COG0519	Catalyzes the synthesis of GMP from XMP
IG196_15140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG196_15170	COG2867	negative regulation of translational initiation
IG196_15175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IG196_15210	COG1217	gtp-binding protein TYPA
IG196_15215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IG196_15220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IG196_15225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IG196_15230	COG2251	uridine kinase activity
IG196_15230	COG0195	Participates in both transcription termination and antitermination
IG196_15235	COG0779	Required for maturation of 30S ribosomal subunits
IG196_15240	COG0477	Major facilitator Superfamily
IG196_15245	COG4172	Belongs to the ABC transporter superfamily
IG196_15250	COG4239	(ABC) transporter, permease
IG196_15255	COG4174	ABC transporter (Permease)
IG196_15260	COG4166	transmembrane transport
IG196_15270	COG1793	dna ligase
IG196_15335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IG196_15355	COG0583	DNA-binding transcription factor activity
IG196_15360	COG0436	Aminotransferase
IG196_15380	COG1643	Atp-dependent helicase
IG196_15385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_15390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IG196_15390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IG196_15395	COG1280	lysine exporter protein (LysE YggA)
IG196_15410	COG2171	N-acyltransferase activity
IG196_15420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_15425	COG2890	protein-(glutamine-N5) methyltransferase activity
IG196_15430	COG0488	(ABC) transporter
IG196_15460	COG1228	amidohydrolase
IG196_15480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IG196_15495	COG0823	Involved in the tonB-independent uptake of proteins
IG196_15500	COG1132	(ABC) transporter
IG196_15505	COG1802	Transcriptional regulator
IG196_15510	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_15515	COG3246	L-lysine catabolic process to acetate
IG196_15525	COG1530	ribonuclease E activity
IG196_15530	COG0424	maF-like protein
IG196_15535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IG196_15540	COG0799	negative regulation of ribosome biogenesis
IG196_15545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IG196_15550	COG0408	coproporphyrinogen oxidase activity
IG196_15555	COG0151	Belongs to the GarS family
IG196_15560	COG0217	transcriptional regulatory protein
IG196_15565	COG2226	methyltransferase
IG196_15590	COG1538	Outer membrane efflux protein
IG196_15600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_15605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IG196_15610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IG196_15615	COG4208	sulfate ABC transporter
IG196_15625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IG196_15635	COG0450	alkyl hydroperoxide reductase
IG196_15645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG196_15650	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_15670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_15690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IG196_15695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_15705	COG1045	serine acetyltransferase
IG196_15725	COG0778	Nitroreductase
IG196_15735	COG1116	anion transmembrane transporter activity
IG196_15740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_15745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_15750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_15755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_15760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_15765	COG0431	NADPH-dependent FMN reductase
IG196_15775	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IG196_15780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_15780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IG196_15790	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_15800	COG5002	protein histidine kinase activity
IG196_15805	COG0745	RESPONSE REGULATOR receiver
IG196_15810	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
IG196_15815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG196_15825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG196_15830	COG0427	acetyl-CoA hydrolase
IG196_15835	COG0583	DNA-binding transcription factor activity
IG196_15840	COG0251	oxidation-reduction process
IG196_15850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_15855	COG0583	DNA-binding transcription factor activity
IG196_15860	COG0667	Aldo Keto reductase
IG196_15880	COG0789	Transcriptional regulator
IG196_15890	COG2382	esterase
IG196_15900	COG1446	asparaginase
IG196_15905	COG4172	Belongs to the ABC transporter superfamily
IG196_15910	COG0747	negative chemotaxis
IG196_15915	COG0601	transmembrane transport
IG196_15920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_15935	COG2205	protein histidine kinase activity
IG196_15935	COG4191	Histidine kinase
IG196_15935	COG0745	RESPONSE REGULATOR receiver
IG196_15970	COG0529	Catalyzes the synthesis of activated sulfate
IG196_15970	COG2895	sulfate adenylyltransferase (ATP) activity
IG196_15975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IG196_15980	COG0492	ferredoxin-NADP+ reductase activity
IG196_16015	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IG196_16035	COG0351	phosphomethylpyrimidine kinase
IG196_16050	COG2022	thiamine diphosphate biosynthetic process
IG196_16125	COG0154	amidase activity
IG196_16145	COG2267	carboxylic ester hydrolase activity
IG196_16175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_16180	COG0642	Histidine kinase
IG196_16190	COG1414	Transcriptional regulator
IG196_16210	COG2207	Transcriptional regulator
IG196_16210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IG196_16220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IG196_16225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IG196_16230	COG1414	Transcriptional regulator
IG196_16240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_16245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_16250	COG1183	phosphatidylcholine synthase activity
IG196_16255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IG196_16260	COG0440	acetolactate synthase activity
IG196_16265	COG0028	Belongs to the TPP enzyme family
IG196_16290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IG196_16345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_16405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_16415	COG1012	belongs to the aldehyde dehydrogenase family
IG196_16435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IG196_16440	COG0746	molybdenum cofactor guanylyltransferase activity
IG196_16450	COG0328	RNA-DNA hybrid ribonuclease activity
IG196_16455	COG2226	methyltransferase
IG196_16460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG196_16465	COG1388	LysM domain
IG196_16465	COG0741	lytic transglycosylase activity
IG196_16470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG196_16470	COG0475	glutathione-regulated potassium exporter activity
IG196_16475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_16485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_16495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IG196_16500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IG196_16505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IG196_16525	COG1074	ATP-dependent DNA helicase activity
IG196_16540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IG196_16545	COG0673	inositol 2-dehydrogenase activity
IG196_16550	COG0254	rRNA binding
IG196_16560	COG0534	Mate efflux family protein
IG196_16580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IG196_16585	COG0581	inorganic phosphate transmembrane transporter activity
IG196_16590	COG0573	inorganic phosphate transmembrane transporter activity
IG196_16595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IG196_16600	COG0248	Ppx GppA phosphatase
IG196_16615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IG196_16625	COG0492	ferredoxin-NADP+ reductase activity
IG196_16635	COG0625	glutathione transferase activity
IG196_16655	COG0582	viral genome integration into host DNA
IG196_17025	COG0582	viral genome integration into host DNA
IG196_17070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_17075	COG0589	response to stress
IG196_17085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_17110	COG0589	response to stress
IG196_17120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IG196_17125	COG3932	Exopolysaccharide synthesis, ExoD
IG196_17160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_17180	COG1063	alcohol dehydrogenase
IG196_17225	COG0589	response to stress
IG196_17255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IG196_17265	COG0784	Response regulator, receiver
IG196_17265	COG4191	Histidine kinase
IG196_17285	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_17295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IG196_17330	COG0642	Histidine kinase
IG196_17350	COG1022	Amp-dependent synthetase and ligase
IG196_17365	COG2814	Major facilitator Superfamily
IG196_17370	COG1309	transcriptional regulator
IG196_17375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_17380	COG1132	(ABC) transporter
IG196_17535	COG1024	Enoyl-CoA hydratase
IG196_17555	COG1522	sequence-specific DNA binding
IG196_17560	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_17600	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_17620	COG1295	ribonuclease BN
IG196_17630	COG2059	Chromate
IG196_17635	COG0667	Aldo Keto reductase
IG196_17655	COG0644	oxidoreductase
IG196_17660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG196_17675	COG4181	ATPase activity
IG196_17695	COG0626	cystathionine gamma-synthase activity
IG196_17700	COG0501	Belongs to the peptidase M48B family
IG196_17720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IG196_17725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IG196_17735	COG0330	HflC and HflK could
IG196_17740	COG0330	HflC and HflK could
IG196_17745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IG196_17750	COG1923	regulation of RNA biosynthetic process
IG196_17755	COG1160	GTP binding
IG196_17760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_17770	COG0124	histidyl-tRNA synthetase
IG196_17775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IG196_17790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IG196_17795	COG0105	UTP biosynthetic process
IG196_17800	COG1187	pseudouridine synthase activity
IG196_17805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG196_17810	COG0564	pseudouridine synthase activity
IG196_17820	COG1199	ATP-dependent helicase activity
IG196_17840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IG196_17845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG196_17850	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG196_17855	COG0567	Dehydrogenase, E1 component
IG196_17875	COG2368	4-hydroxyphenylacetate
IG196_17885	COG2133	pyrroloquinoline quinone binding
IG196_17890	COG0791	NLP P60 protein
IG196_17900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG196_17910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG196_17915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IG196_17925	COG4566	intracellular signal transduction
IG196_17930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG196_17945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IG196_17950	COG0167	dihydroorotate dehydrogenase activity
IG196_17965	COG0579	oxidoreductase
IG196_18000	COG1596	polysaccharide export
IG196_18005	COG0489	protein tyrosine kinase activity
IG196_18005	COG3206	protein involved in exopolysaccharide biosynthesis
IG196_18010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IG196_18015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_18045	COG0297	glycogen (starch) synthase activity
IG196_18050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IG196_18055	COG2197	response regulator
IG196_18065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IG196_18085	COG0443	Heat shock 70 kDa protein
IG196_18100	COG0822	iron-sulfur transferase activity
IG196_18105	COG1104	cysteine desulfurase activity
IG196_18110	COG1959	2 iron, 2 sulfur cluster binding
IG196_18115	COG0556	nucleotide-excision repair
IG196_18130	COG2878	Part of a membrane complex involved in electron transport
IG196_18140	COG0697	spore germination
IG196_18145	COG1522	sequence-specific DNA binding
IG196_18155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IG196_18160	COG4770	biotin carboxylase activity
IG196_18165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG196_18170	COG1703	isobutyryl-CoA mutase activity
IG196_18180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_18180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_18185	COG1802	Transcriptional regulator
IG196_18195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IG196_18215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IG196_18225	COG1802	Transcriptional regulator
IG196_18230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG196_18240	COG4166	transmembrane transport
IG196_18255	COG4172	Belongs to the ABC transporter superfamily
IG196_18265	COG2808	Putative FMN-binding domain
IG196_18280	COG0028	Belongs to the TPP enzyme family
IG196_18310	COG3813	Protein conserved in bacteria
IG196_18325	COG0346	lactoylglutathione lyase activity
IG196_18350	COG1595	DNA-templated transcription, initiation
IG196_18355	COG3712	iron ion homeostasis
IG196_18395	COG1733	regulation of RNA biosynthetic process
IG196_18410	COG0583	DNA-binding transcription factor activity
IG196_18415	COG2249	NAD(P)H dehydrogenase (quinone) activity
IG196_18430	COG2076	Multidrug Resistance protein
IG196_18465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IG196_18515	COG4774	siderophore transport
IG196_18530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG196_18530	COG4651	solute:proton antiporter activity
IG196_18535	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IG196_18540	COG1301	dicarboxylic acid transport
IG196_18545	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_18555	COG1546	Belongs to the CinA family
IG196_18555	COG1058	Belongs to the CinA family
IG196_18575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_18580	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IG196_18590	COG0583	DNA-binding transcription factor activity
IG196_18600	COG0183	Belongs to the thiolase family
IG196_18605	COG3243	poly(R)-hydroxyalkanoic acid synthase
IG196_18640	COG3045	CreA protein
IG196_18650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_18660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_18710	COG1742	UPF0060 membrane protein
IG196_18725	COG1360	Flagellar Motor Protein
IG196_18795	COG0387	Pfam Sodium calcium exchanger
IG196_18805	COG2197	response regulator
IG196_18860	COG4964	Belongs to the GSP D family
IG196_18880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_18885	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_18920	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_18930	COG2814	Major facilitator Superfamily
IG196_18950	COG0604	alcohol dehydrogenase
IG196_18960	COG0604	alcohol dehydrogenase
IG196_18960	COG3321	synthase
IG196_18965	COG0583	DNA-binding transcription factor activity
IG196_18970	COG4948	Mandelate Racemase Muconate Lactonizing
IG196_18980	COG0583	DNA-binding transcription factor activity
IG196_18985	COG1902	pentaerythritol trinitrate reductase activity
IG196_18995	COG1595	DNA-templated transcription, initiation
IG196_19025	COG2197	response regulator
IG196_19045	COG0006	proline dipeptidase activity
IG196_19050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG196_19060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG196_19065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG196_19070	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_19090	COG1522	sequence-specific DNA binding
IG196_19105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG196_19115	COG0275	rRNA processing
IG196_19185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG196_19215	COG0392	lysyltransferase activity
IG196_19220	COG5002	protein histidine kinase activity
IG196_19225	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IG196_19235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IG196_19265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG196_19270	COG0417	DNA replication proofreading
IG196_19310	COG0402	S-adenosylhomocysteine deaminase activity
IG196_19330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_19350	COG1024	Enoyl-CoA hydratase
IG196_19355	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_19360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_19370	COG0583	DNA-binding transcription factor activity
IG196_19400	COG0730	response to heat
IG196_19405	COG0402	S-adenosylhomocysteine deaminase activity
IG196_19425	COG2894	cell division
IG196_19430	COG1215	transferase activity, transferring glycosyl groups
IG196_19435	COG1215	transferase activity, transferring glycosyl groups
IG196_19440	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IG196_19445	COG0457	Tetratricopeptide repeat
IG196_19480	COG3436	PFAM IS66 Orf2 family protein
IG196_19485	COG4372	Transposase
IG196_19510	COG0776	regulation of translation
IG196_19515	COG0072	phenylalanine-tRNA ligase activity
IG196_19515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG196_19520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IG196_19525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IG196_19530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IG196_19535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IG196_19540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IG196_19565	COG2207	Transcriptional regulator
IG196_19575	COG0028	Belongs to the TPP enzyme family
IG196_19580	COG1309	transcriptional regulator
IG196_19590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_19595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_19610	COG0673	inositol 2-dehydrogenase activity
IG196_19625	COG3214	Protein conserved in bacteria
IG196_19630	COG4774	siderophore transport
IG196_19635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG196_19650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IG196_19655	COG0802	atpase or kinase
IG196_19660	COG0860	N-Acetylmuramoyl-L-alanine amidase
IG196_19670	COG2226	methyltransferase
IG196_19675	COG0789	Transcriptional regulator
IG196_19685	COG0586	Pfam SNARE associated Golgi protein
IG196_19695	COG0583	DNA-binding transcription factor activity
IG196_19700	COG2271	Major facilitator Superfamily
IG196_19705	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_19710	COG0129	dihydroxy-acid dehydratase activity
IG196_19715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IG196_19720	COG0477	Major facilitator Superfamily
IG196_19750	COG2207	Transcriptional regulator
IG196_19755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IG196_19760	COG4181	ATPase activity
IG196_19780	COG0625	glutathione transferase activity
IG196_19790	COG2186	Transcriptional regulator
IG196_19805	COG3795	YCII-related domain
IG196_19810	COG4941	Belongs to the sigma-70 factor family
IG196_19895	COG1566	PFAM secretion protein HlyD family protein
IG196_19905	COG1846	Transcriptional regulator
IG196_19910	COG1132	(ABC) transporter
IG196_19920	COG0494	nUDIX hydrolase
IG196_19930	COG1007	ATP synthesis coupled electron transport
IG196_19945	COG0713	ATP synthesis coupled electron transport
IG196_19955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_19960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IG196_19965	COG1034	ATP synthesis coupled electron transport
IG196_19980	COG0649	NAD binding
IG196_19985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_19990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_19995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_20010	COG0149	triose-phosphate isomerase activity
IG196_20020	COG1185	polyribonucleotide nucleotidyltransferase activity
IG196_20025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IG196_20040	COG0436	Aminotransferase
IG196_20045	COG0683	leucine binding
IG196_20060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IG196_20065	COG3707	response regulator
IG196_20070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_20075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_20080	COG1116	anion transmembrane transporter activity
IG196_20090	COG2223	nitrite transmembrane transporter activity
IG196_20100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG196_20115	COG0243	molybdopterin cofactor binding
IG196_20120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IG196_20135	COG0791	NLP P60 protein
IG196_20140	COG2081	HI0933 family
IG196_20145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IG196_20155	COG0494	nUDIX hydrolase
IG196_20170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_20175	COG0385	Bile acid
IG196_20180	COG2072	flavoprotein involved in K transport
IG196_20185	COG0300	oxidoreductase activity
IG196_20190	COG1063	alcohol dehydrogenase
IG196_20195	COG3842	ATPase activity
IG196_20200	COG0395	ABC-type sugar transport system, permease component
IG196_20205	COG1175	transmembrane transport
IG196_20210	COG1653	transport
IG196_20220	COG0312	modulator of DNA gyrase
IG196_20230	COG0521	Mo-molybdopterin cofactor biosynthetic process
IG196_20270	COG2205	protein histidine kinase activity
IG196_20275	COG0475	glutathione-regulated potassium exporter activity
IG196_20300	COG0789	Transcriptional regulator
IG196_20310	COG0024	Methionine aminopeptidase
IG196_20345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IG196_20350	COG1045	serine acetyltransferase
IG196_20360	COG0483	inositol monophosphate 1-phosphatase activity
IG196_20365	COG1289	transmembrane transporter activity
IG196_20380	COG1522	sequence-specific DNA binding
IG196_20400	COG2311	Membrane
IG196_20410	COG0583	DNA-binding transcription factor activity
IG196_20435	COG3119	arylsulfatase activity
IG196_20445	COG3039	Transposase
IG196_20470	COG2274	protein secretion by the type I secretion system
IG196_20490	COG0784	Response regulator, receiver
IG196_20490	COG2205	protein histidine kinase activity
IG196_20490	COG5002	protein histidine kinase activity
IG196_20495	COG1024	Enoyl-CoA hydratase
IG196_20500	COG1960	acyl-CoA dehydrogenase activity
IG196_20505	COG1960	acyl-CoA dehydrogenase activity
IG196_20510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_20530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_20535	COG0583	DNA-binding transcription factor activity
IG196_20540	COG1695	Transcriptional regulator
IG196_20545	COG2375	cellular response to nickel ion
IG196_20550	COG0598	Magnesium transport protein CorA
IG196_20570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IG196_20590	COG4941	Belongs to the sigma-70 factor family
IG196_20595	COG3795	YCII-related domain
IG196_20600	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_20610	COG4585	Histidine kinase
IG196_20635	COG1968	undecaprenyl-diphosphatase activity
IG196_20650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_20655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG196_20660	COG1737	Transcriptional regulator
IG196_20720	COG2972	Histidine kinase
IG196_20735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG196_20775	COG3177	Filamentation induced by cAMP protein fic
IG196_20780	COG0004	ammonium transporteR
IG196_20805	COG4774	siderophore transport
IG196_20820	COG1131	(ABC) transporter
IG196_20825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IG196_20835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IG196_20865	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_20870	COG2201	protein-glutamate methylesterase activity
IG196_20875	COG2918	glutathione biosynthetic process
IG196_20900	COG0523	cobalamin synthesis protein
IG196_20935	COG0583	DNA-binding transcription factor activity
IG196_20940	COG0405	Gamma-glutamyltransferase
IG196_20955	COG4774	siderophore transport
IG196_20995	COG2354	Protein conserved in bacteria
IG196_21010	COG4628	conserved protein (DUF2132)
IG196_21025	COG0564	pseudouridine synthase activity
IG196_21030	COG0589	response to stress
IG196_21050	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IG196_21055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG196_21065	COG1252	NADH dehydrogenase
IG196_21090	COG3485	protocatechuate 3,4-dioxygenase
IG196_21100	COG3246	L-lysine catabolic process to acetate
IG196_21135	COG4773	Receptor
IG196_21140	COG3712	iron ion homeostasis
IG196_21145	COG1595	DNA-templated transcription, initiation
IG196_21150	COG0300	oxidoreductase activity
IG196_21160	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_21170	COG1764	response to oxidative stress
IG196_21190	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_21200	COG2271	Major facilitator Superfamily
IG196_21215	COG0765	amino acid transport
IG196_21220	COG0765	amino acid transport
IG196_21230	COG0583	DNA-binding transcription factor activity
IG196_21235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IG196_21245	COG0454	-acetyltransferase
IG196_21255	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_21275	COG2132	Multicopper oxidase
IG196_21295	COG3191	aminopeptidase activity
IG196_21315	COG0789	Transcriptional regulator
IG196_21330	COG0488	(ABC) transporter
IG196_21335	COG0513	Belongs to the DEAD box helicase family
IG196_21355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_21360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_21365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_21370	COG2186	Transcriptional regulator
IG196_21375	COG0129	dihydroxy-acid dehydratase activity
IG196_21380	COG3734	2-keto-3-deoxy-galactonokinase
IG196_21385	COG0800	Aldolase
IG196_21390	COG0235	Class ii aldolase
IG196_21400	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_21425	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_21435	COG3842	ATPase activity
IG196_21450	COG0346	lactoylglutathione lyase activity
IG196_21465	COG0800	Aldolase
IG196_21475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_21480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_21485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_21490	COG3265	gluconokinase activity
IG196_21515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_21520	COG0259	pyridoxamine-phosphate oxidase activity
IG196_21550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG196_21555	COG1309	transcriptional regulator
IG196_21560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG196_21585	COG2169	Transcriptional regulator
IG196_21595	COG0697	spore germination
IG196_21610	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_21615	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_21620	COG3268	Saccharopine dehydrogenase
IG196_21640	COG0625	glutathione transferase activity
IG196_21715	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IG196_21730	COG1595	DNA-templated transcription, initiation
IG196_21775	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_21800	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_21825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG196_21850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG196_21875	COG0285	dihydrofolate synthase activity
IG196_21880	COG1393	Belongs to the ArsC family
IG196_21890	COG3123	guanosine phosphorylase activity
IG196_21895	COG0137	argininosuccinate synthase activity
IG196_21905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IG196_21910	COG1666	GTP binding
IG196_21920	COG0251	oxidation-reduction process
IG196_21925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IG196_21930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IG196_21935	COG0667	Aldo Keto reductase
IG196_21940	COG2267	carboxylic ester hydrolase activity
IG196_21950	COG1464	Belongs to the NlpA lipoprotein family
IG196_21965	COG1464	Belongs to the NlpA lipoprotein family
IG196_21970	COG2011	ABC-type metal ion transport system permease component
IG196_21980	COG1464	Belongs to the NlpA lipoprotein family
IG196_21995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG196_22000	COG0308	aminopeptidase N
IG196_22005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IG196_22015	COG1403	HNH endonuclease
IG196_22120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IG196_22125	COG4638	Rieske (2fe-2S)
IG196_22140	COG0683	leucine binding
IG196_22150	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG196_22205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_22210	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_22220	COG0513	Belongs to the DEAD box helicase family
IG196_22225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IG196_22235	COG2154	pterin-4-alpha-carbinolamine dehydratase
IG196_22240	COG1162	GTPase activity
IG196_22250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_22255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IG196_22260	COG0494	nUDIX hydrolase
IG196_22265	COG0335	large ribosomal subunit rRNA binding
IG196_22270	COG0336	Belongs to the RNA methyltransferase TrmD family
IG196_22275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IG196_22280	COG0228	four-way junction DNA binding
IG196_22295	COG0306	phosphate transporter
IG196_22300	COG1392	Phosphate transport regulator
IG196_22315	COG0617	tRNA 3'-terminal CCA addition
IG196_22320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IG196_22325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IG196_22345	COG1917	Cupin 2, conserved barrel domain protein
IG196_22345	COG4977	sequence-specific DNA binding
IG196_22350	COG4941	Belongs to the sigma-70 factor family
IG196_22360	COG3795	YCII-related domain
IG196_22380	COG0728	peptidoglycan biosynthetic process
IG196_22385	COG0268	Binds directly to 16S ribosomal RNA
IG196_22395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IG196_22400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG196_22410	COG0727	PFAM Uncharacterised protein family (UPF0153)
IG196_22415	COG1522	sequence-specific DNA binding
IG196_22420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG196_22430	COG3483	tryptophan 2,3-dioxygenase activity
IG196_22440	COG0583	DNA-binding transcription factor activity
IG196_22445	COG3960	tartronate-semialdehyde synthase activity
IG196_22450	COG3622	Belongs to the hyi family
IG196_22455	COG2084	Dehydrogenase
IG196_22485	COG1414	Transcriptional regulator
IG196_22490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_22505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_22515	COG1116	anion transmembrane transporter activity
IG196_22520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_22550	COG0745	RESPONSE REGULATOR receiver
IG196_22565	COG0642	Histidine kinase
IG196_22575	COG2267	carboxylic ester hydrolase activity
IG196_22585	COG1733	regulation of RNA biosynthetic process
IG196_22605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_22615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_22625	COG0829	nickel cation binding
IG196_22630	COG0583	DNA-binding transcription factor activity
IG196_22665	COG2855	membrane
IG196_22675	COG2879	small protein
IG196_22680	COG1966	Carbon starvation protein
IG196_22710	COG4969	Belongs to the N-Me-Phe pilin family
IG196_22730	COG0791	NLP P60 protein
IG196_22745	COG1106	Psort location Cytoplasmic, score
IG196_22790	COG0667	Aldo Keto reductase
IG196_22795	COG3540	Alkaline phosphatase
IG196_22805	COG2814	Major facilitator Superfamily
IG196_22825	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_22845	COG0477	Major facilitator Superfamily
IG196_22865	COG0613	PHP domain protein
IG196_22875	COG0009	L-threonylcarbamoyladenylate synthase
IG196_22880	COG1994	Peptidase M50
IG196_22885	COG0180	Tryptophanyl-tRNA synthetase
IG196_22890	COG2197	response regulator
IG196_22895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_22895	COG2205	protein histidine kinase activity
IG196_22900	COG1950	PFAM Membrane protein of
IG196_22910	COG0583	DNA-binding transcription factor activity
IG196_22915	COG1473	amidohydrolase
IG196_22920	COG0583	DNA-binding transcription factor activity
IG196_22930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_22970	COG1191	sigma factor activity
IG196_22985	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG196_23010	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IG196_23015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IG196_23020	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IG196_23025	COG2198	Histidine kinase
IG196_23025	COG0643	Histidine kinase
IG196_23050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG196_23070	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IG196_23075	COG1334	flagellar protein FlaG
IG196_23085	COG1677	Flagellar hook-basal body complex protein FliE
IG196_23120	COG1580	Controls the rotational direction of flagella during chemotaxis
IG196_23130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IG196_23145	COG1987	bacterial-type flagellum assembly
IG196_23170	COG3275	phosphorelay sensor kinase activity
IG196_23175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_23185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IG196_23235	COG1256	bacterial-type flagellum assembly
IG196_23245	COG0835	chemotaxis
IG196_23250	COG0840	transmembrane signaling receptor activity
IG196_23265	COG0840	transmembrane signaling receptor activity
IG196_23270	COG3951	Flagellar rod assembly protein muramidase FlgJ
IG196_23270	COG1705	Flagellar rod assembly protein muramidase FlgJ
IG196_23275	COG1706	bacterial-type flagellum-dependent cell motility
IG196_23280	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IG196_23305	COG1558	bacterial-type flagellum-dependent cell motility
IG196_23310	COG1815	bacterial-type flagellum-dependent cell motility
IG196_23340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_23345	COG0235	Class ii aldolase
IG196_23350	COG0625	glutathione transferase activity
IG196_23355	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_23360	COG1396	sequence-specific DNA binding
IG196_23375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IG196_23380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_23385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IG196_23390	COG1047	Peptidyl-prolyl cis-trans
IG196_23395	COG2003	Belongs to the UPF0758 family
IG196_23405	COG0737	Belongs to the 5'-nucleotidase family
IG196_23420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IG196_23430	COG0765	amino acid transport
IG196_23435	COG0765	amino acid transport
IG196_23455	COG1012	belongs to the aldehyde dehydrogenase family
IG196_23465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_23470	COG0765	amino acid transport
IG196_23475	COG1126	abc transporter atp-binding protein
IG196_23480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_23485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG196_23500	COG0477	Major facilitator Superfamily
IG196_23505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG196_23510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG196_23515	COG1845	cytochrome c oxidase, subunit III
IG196_23520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IG196_23535	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IG196_23540	COG1272	protein, Hemolysin III
IG196_23545	COG2900	Belongs to the SlyX family
IG196_23550	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_23565	COG0583	DNA-binding transcription factor activity
IG196_23570	COG0477	Major facilitator Superfamily
IG196_23575	COG0583	DNA-binding transcription factor activity
IG196_23585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IG196_23590	COG0709	Synthesizes selenophosphate from selenide and ATP
IG196_23595	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_23600	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IG196_23605	COG3639	organic phosphonate transmembrane transporter activity
IG196_23610	COG3639	organic phosphonate transmembrane transporter activity
IG196_23615	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IG196_23620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG196_23630	COG0243	molybdopterin cofactor binding
IG196_23650	COG0725	ABC transporter, periplasmic molybdate-binding protein
IG196_23655	COG4149	molybdate abc transporter
IG196_23665	COG0778	Nitroreductase
IG196_23680	COG0583	DNA-binding transcription factor activity
IG196_23685	COG0489	protein tyrosine kinase activity
IG196_23695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_23700	COG1473	amidohydrolase
IG196_23705	COG1522	sequence-specific DNA binding
IG196_23715	COG3132	Protein of unknown function, DUF480
IG196_23725	COG0473	3-isopropylmalate dehydrogenase activity
IG196_23730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_23755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_23765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG196_23765	COG1024	Enoyl-CoA hydratase
IG196_23770	COG0659	secondary active sulfate transmembrane transporter activity
IG196_23790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IG196_23795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IG196_23800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IG196_23805	COG0602	queuosine metabolic process
IG196_23810	COG0720	synthase
IG196_23815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IG196_23825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IG196_23830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IG196_23840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG196_23845	COG0588	phosphoglycerate mutase activity
IG196_23850	COG0793	Belongs to the peptidase S41A family
IG196_23855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IG196_23860	COG2982	Protein involved in outer membrane biogenesis
IG196_23870	COG2197	response regulator
IG196_23875	COG4585	Histidine kinase
IG196_23880	COG5487	UPF0391 membrane protein
IG196_23900	COG2823	Periplasmic or secreted lipoprotein
IG196_23930	COG0494	nUDIX hydrolase
IG196_23945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IG196_23965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IG196_23980	COG2226	methyltransferase
IG196_24005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_24015	COG1175	transmembrane transport
IG196_24020	COG0395	ABC-type sugar transport system, permease component
IG196_24025	COG3842	ATPase activity
IG196_24030	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_24035	COG3264	Mechanosensitive ion channel
IG196_24035	COG1511	domain protein
IG196_24040	COG1522	sequence-specific DNA binding
IG196_24050	COG4120	Belongs to the binding-protein-dependent transport system permease family
IG196_24055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IG196_24070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IG196_24075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IG196_24080	COG2890	protein-(glutamine-N5) methyltransferase activity
IG196_24085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IG196_24090	COG1253	flavin adenine dinucleotide binding
IG196_24095	COG0741	lytic transglycosylase activity
IG196_24100	COG0442	prolyl-tRNA aminoacylation
IG196_24105	COG0494	nUDIX hydrolase
IG196_24115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IG196_24120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IG196_24125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IG196_24130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IG196_24135	COG0142	geranyltranstransferase activity
IG196_24155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IG196_24165	COG1696	Membrane protein involved in D-alanine export
IG196_24175	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IG196_24180	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IG196_24185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG196_24185	COG2755	lipolytic protein G-D-S-L family
IG196_24190	COG0494	nUDIX hydrolase
IG196_24200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IG196_24205	COG0653	protein targeting
IG196_24215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IG196_24235	COG0831	urea catabolic process
IG196_24245	COG0832	Belongs to the urease beta subunit family
IG196_24250	COG0804	urea catabolic process
IG196_24265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IG196_24270	COG0830	nickel cation binding
IG196_24275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG196_24285	COG0583	DNA-binding transcription factor activity
IG196_24310	COG0745	RESPONSE REGULATOR receiver
IG196_24330	COG2205	protein histidine kinase activity
IG196_24335	COG0745	RESPONSE REGULATOR receiver
IG196_24340	COG1309	transcriptional regulator
IG196_24350	COG0493	'glutamate synthase
IG196_24360	COG1953	Uracil, thiamine, allantoin
IG196_24385	COG1335	isochorismatase
IG196_24390	COG1335	isochorismatase
IG196_24400	COG0670	Belongs to the BI1 family
IG196_24405	COG1959	2 iron, 2 sulfur cluster binding
IG196_24430	COG0589	response to stress
IG196_24455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_24460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG196_24470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG196_24505	COG3278	Belongs to the heme-copper respiratory oxidase family
IG196_24515	COG2217	Heavy metal translocating P-type atpase
IG196_24565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG196_24570	COG2814	Major facilitator Superfamily
IG196_24575	COG4771	TonB-dependent receptor
IG196_24600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IG196_24605	COG3287	FIST C domain
IG196_24605	COG2200	EAL domain
IG196_24605	COG2199	diguanylate cyclase activity
IG196_24655	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_24660	COG1703	isobutyryl-CoA mutase activity
IG196_24665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_24670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_24670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_24675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_24675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_24680	COG1024	Enoyl-CoA hydratase
IG196_24705	COG3246	L-lysine catabolic process to acetate
IG196_24710	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_24720	COG3246	L-lysine catabolic process to acetate
IG196_24725	COG2175	clavaminate synthase activity
IG196_24750	COG2207	Transcriptional regulator
IG196_24760	COG2175	clavaminate synthase activity
IG196_24765	COG3246	L-lysine catabolic process to acetate
IG196_24795	COG4942	peptidase
IG196_24795	COG1388	LysM domain
IG196_24805	COG5002	protein histidine kinase activity
IG196_24805	COG2205	protein histidine kinase activity
IG196_24805	COG0784	Response regulator, receiver
IG196_24810	COG2197	response regulator
IG196_24825	COG0582	viral genome integration into host DNA
IG196_24835	COG1304	FMN binding
IG196_24840	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_24855	COG0776	regulation of translation
IG196_24920	COG3468	outer membrane autotransporter barrel domain protein
IG196_25005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_25025	COG1473	amidohydrolase
IG196_25045	COG0625	glutathione transferase activity
IG196_25050	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_25090	COG2175	clavaminate synthase activity
IG196_25185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG196_25190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IG196_25195	COG0277	FAD linked oxidase domain protein
IG196_25295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG196_25300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IG196_25320	COG1561	YicC-like family, N-terminal region
IG196_25325	COG0194	GDP metabolic process
IG196_25330	COG1758	RNA polymerase activity
IG196_25335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG196_25365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_25380	COG1420	regulation of RNA biosynthetic process
IG196_25385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IG196_25390	COG0497	DNA recombination
IG196_25395	COG1660	Displays ATPase and GTPase activities
IG196_25405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IG196_25410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IG196_25425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IG196_25435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IG196_25440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IG196_25445	COG0193	aminoacyl-tRNA hydrolase activity
IG196_25455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IG196_25465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_25475	COG4608	Belongs to the ABC transporter superfamily
IG196_25485	COG0747	negative chemotaxis
IG196_25490	COG0154	amidase activity
IG196_25510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_25515	COG0588	phosphoglycerate mutase activity
IG196_25520	COG2267	carboxylic ester hydrolase activity
IG196_25525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IG196_25530	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_25535	COG1984	allophanate hydrolase subunit 2
IG196_25540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_25545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IG196_25550	COG0742	ribosomal rna small subunit methyltransferase
IG196_25565	COG0612	Peptidase, M16
IG196_25570	COG0612	Peptidase, M16
IG196_25580	COG2205	protein histidine kinase activity
IG196_25585	COG2197	response regulator
IG196_25600	COG0583	DNA-binding transcription factor activity
IG196_25610	COG4335	DNA alkylation repair
IG196_25615	COG1999	signal sequence binding
IG196_25620	COG0109	protoheme IX farnesyltransferase activity
IG196_25655	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IG196_25660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG196_25675	COG2226	methyltransferase
IG196_25680	COG1040	competence protein
IG196_25685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IG196_25700	COG0489	protein tyrosine kinase activity
IG196_25720	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_25735	COG1024	Enoyl-CoA hydratase
IG196_25755	COG1960	acyl-CoA dehydrogenase activity
IG196_25770	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IG196_25785	COG5507	3-demethylubiquinone-9 3-methyltransferase
IG196_25795	COG2186	Transcriptional regulator
IG196_25800	COG0154	amidase activity
IG196_25820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IG196_25830	COG0430	RNA-3'-phosphate cyclase activity
IG196_25845	COG1690	Belongs to the RtcB family
IG196_25855	COG4650	regulator
IG196_25870	COG1073	alpha beta
IG196_25880	COG4771	TonB-dependent receptor
IG196_25895	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_25900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_25920	COG0601	transmembrane transport
IG196_25945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_25950	COG0583	DNA-binding transcription factor activity
IG196_25955	COG1012	belongs to the aldehyde dehydrogenase family
IG196_25965	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_25980	COG0395	ABC-type sugar transport system, permease component
IG196_25985	COG0693	protein deglycase activity
IG196_26010	COG0183	Belongs to the thiolase family
IG196_26015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IG196_26025	COG1414	Transcriptional regulator
IG196_26035	COG3063	Type IV pilus biogenesis stability protein PilW
IG196_26060	COG4964	Belongs to the GSP D family
IG196_26120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_26125	COG2274	protein secretion by the type I secretion system
IG196_26135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IG196_26155	COG0583	DNA-binding transcription factor activity
IG196_26160	COG3485	protocatechuate 3,4-dioxygenase
IG196_26165	COG3485	protocatechuate 3,4-dioxygenase
IG196_26175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_26245	COG1902	pentaerythritol trinitrate reductase activity
IG196_26250	COG0697	spore germination
IG196_26280	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_26285	COG1053	succinate dehydrogenase
IG196_26300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG196_26305	COG0540	Belongs to the ATCase OTCase family
IG196_26310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IG196_26315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IG196_26320	COG1678	Uncharacterized ACR, COG1678
IG196_26325	COG0415	Belongs to the DNA photolyase family
IG196_26330	COG2198	Histidine kinase
IG196_26330	COG0784	Response regulator, receiver
IG196_26330	COG0643	Histidine kinase
IG196_26355	COG1773	rubredoxin
IG196_26365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IG196_26370	COG0154	amidase activity
IG196_26375	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_26390	COG0138	bifunctional purine biosynthesis protein purh
IG196_26395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IG196_26405	COG1238	metal cluster binding
IG196_26415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_26425	COG0012	GTP binding
IG196_26430	COG1879	ABC-type sugar transport system periplasmic component
IG196_26435	COG1129	ABC transporter
IG196_26440	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_26445	COG1609	Transcriptional regulator
IG196_26450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG196_26455	COG1869	D-ribose catabolic process
IG196_26465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_26485	COG1024	Enoyl-CoA hydratase
IG196_26550	COG1960	acyl-CoA dehydrogenase activity
IG196_26555	COG1960	acyl-CoA dehydrogenase activity
IG196_26565	COG0778	Nitroreductase
IG196_26585	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_26590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_26610	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_26660	COG1024	Enoyl-CoA hydratase
IG196_26705	COG0183	Belongs to the thiolase family
IG196_26715	COG1024	Enoyl-CoA hydratase
IG196_26725	COG1024	Enoyl-CoA hydratase
IG196_26725	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_26735	COG1946	Acyl-CoA thioesterase
IG196_26740	COG1024	Enoyl-CoA hydratase
IG196_26740	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_26745	COG0183	Belongs to the thiolase family
IG196_26750	COG2909	trisaccharide binding
IG196_26755	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_26770	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_26775	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_26780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_26795	COG1024	Enoyl-CoA hydratase
IG196_26805	COG1960	acyl-CoA dehydrogenase activity
IG196_26810	COG1960	acyl-CoA dehydrogenase activity
IG196_26830	COG2255	four-way junction helicase activity
IG196_26835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IG196_26840	COG2267	carboxylic ester hydrolase activity
IG196_26845	COG0671	phosphoesterase, PA-phosphatase related
IG196_26845	COG2453	phosphatase
IG196_26860	COG4589	Belongs to the CDS family
IG196_26925	COG1012	belongs to the aldehyde dehydrogenase family
IG196_26940	COG0632	four-way junction helicase activity
IG196_26945	COG1702	phosphate starvation-inducible protein PhoH
IG196_26950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IG196_26955	COG4106	trans-aconitate 2-methyltransferase activity
IG196_26960	COG1490	D-aminoacyl-tRNA deacylase activity
IG196_26965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IG196_26980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IG196_26990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IG196_26995	COG2814	Major facilitator Superfamily
IG196_27000	COG0316	Belongs to the HesB IscA family
IG196_27005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IG196_27010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IG196_27025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IG196_27030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IG196_27045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IG196_27065	COG3243	poly(R)-hydroxyalkanoic acid synthase
IG196_27075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IG196_27100	COG4555	ABC transporter
IG196_27125	COG2423	ornithine cyclodeaminase activity
IG196_27130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IG196_27135	COG0683	leucine binding
IG196_27145	COG0477	Major facilitator Superfamily
IG196_27165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG196_27170	COG2146	nitrite reductase [NAD(P)H] activity
IG196_27175	COG2116	formate transmembrane transporter activity
IG196_27180	COG0515	serine threonine protein kinase
IG196_27180	COG2815	serine threonine protein kinase
IG196_27190	COG1254	Belongs to the acylphosphatase family
IG196_27200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_27215	COG1414	Transcriptional regulator
IG196_27220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_27245	COG1024	Enoyl-CoA hydratase
IG196_27250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG196_27255	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_27260	COG1960	acyl-CoA dehydrogenase activity
IG196_27275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG196_27280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IG196_27285	COG3012	SEC-C Motif Domain Protein
IG196_27320	COG1408	metallophosphoesterase
IG196_27325	COG1960	acyl-CoA dehydrogenase activity
IG196_27335	COG0183	Belongs to the thiolase family
IG196_27340	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IG196_27345	COG0288	reversible hydration of carbon dioxide
IG196_27350	COG0789	Transcriptional regulator
IG196_27365	COG0564	pseudouridine synthase activity
IG196_27385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IG196_27400	COG0751	glycine-tRNA ligase activity
IG196_27405	COG0752	glycyl-tRNA synthetase alpha subunit
IG196_27410	COG1597	lipid kinase activity
IG196_27420	COG0671	phosphoesterase, PA-phosphatase related
IG196_27435	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IG196_27450	COG1522	sequence-specific DNA binding
IG196_27465	COG3186	Phenylalanine-4-hydroxylase
IG196_27470	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_27510	COG0488	(ABC) transporter
IG196_27515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_27560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_27570	COG3550	peptidyl-serine autophosphorylation
IG196_27610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG196_27635	COG0439	Biotin carboxylase
IG196_27640	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_27655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG196_27655	COG2124	cytochrome p450
IG196_27685	COG1505	serine-type exopeptidase activity
IG196_27700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IG196_27730	COG2084	Dehydrogenase
IG196_27740	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IG196_27745	COG0792	nuclease activity
IG196_27750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IG196_27770	COG1309	transcriptional regulator
IG196_27775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_27780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_27830	COG3118	belongs to the thioredoxin family
IG196_27850	COG1879	ABC-type sugar transport system periplasmic component
IG196_27855	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_27870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IG196_27875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IG196_27880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IG196_27885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IG196_27890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG196_27895	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IG196_27905	COG0356	it plays a direct role in the translocation of protons across the membrane
IG196_27920	COG2921	Belongs to the UPF0250 family
IG196_27925	COG0321	lipoyl(octanoyl) transferase activity
IG196_27930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IG196_27940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IG196_27945	COG1012	belongs to the aldehyde dehydrogenase family
IG196_27955	COG2271	Major facilitator Superfamily
IG196_27970	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_27975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IG196_27995	COG2130	NADP-dependent
IG196_28030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_28035	COG1136	(ABC) transporter
IG196_28035	COG0577	efflux transmembrane transporter activity
IG196_28040	COG1538	Outer membrane efflux protein
IG196_28045	COG2205	protein histidine kinase activity
IG196_28070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG196_28075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG196_28090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_28095	COG3909	cytochrome
IG196_28110	COG0678	peroxiredoxin activity
IG196_28115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IG196_28120	COG0255	Belongs to the universal ribosomal protein uL29 family
IG196_28125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IG196_28130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IG196_28135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IG196_28140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IG196_28145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IG196_28150	COG0089	rRNA binding
IG196_28155	COG0088	Forms part of the polypeptide exit tunnel
IG196_28160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IG196_28175	COG0051	transcription antitermination factor activity, RNA binding
IG196_28180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG196_28185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG196_28190	COG0049	tRNA binding
IG196_28195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IG196_28200	COG1686	Belongs to the peptidase S11 family
IG196_28205	COG2945	thiolester hydrolase activity
IG196_28220	COG1981	membrane
IG196_28230	COG0598	Magnesium transport protein CorA
IG196_28240	COG0583	DNA-binding transcription factor activity
IG196_28250	COG0412	Dienelactone hydrolase
IG196_28260	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_28265	COG2095	MarC family integral membrane protein
IG196_28280	COG1022	Amp-dependent synthetase and ligase
IG196_28300	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_28315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IG196_28320	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_28335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IG196_28340	COG1652	LysM domain
IG196_28345	COG2207	Transcriptional regulator
IG196_28360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IG196_28385	COG0640	Transcriptional regulator
IG196_28395	COG0574	Belongs to the PEP-utilizing enzyme family
IG196_28395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG196_28405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_28410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IG196_28420	COG0640	Transcriptional regulator
IG196_28435	COG0625	glutathione transferase activity
IG196_28445	COG1131	(ABC) transporter
IG196_28450	COG0842	Transport permease protein
IG196_28460	COG1846	Transcriptional regulator
IG196_28465	COG1764	response to oxidative stress
IG196_28475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IG196_28480	COG0583	DNA-binding transcription factor activity
IG196_28485	COG1960	acyl-CoA dehydrogenase activity
IG196_28505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_28540	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IG196_28550	COG0714	Associated with various cellular activities
IG196_28570	COG0326	Molecular chaperone. Has ATPase activity
IG196_28575	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_28580	COG0583	DNA-binding transcription factor activity
IG196_28590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IG196_28600	COG0642	Histidine kinase
IG196_28615	COG1187	pseudouridine synthase activity
IG196_28620	COG1051	belongs to the nudix hydrolase family
IG196_28620	COG1056	cytidyltransferase-related domain
IG196_28630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IG196_28650	COG0745	RESPONSE REGULATOR receiver
IG196_28655	COG2205	protein histidine kinase activity
IG196_28665	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IG196_28670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IG196_28675	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IG196_28700	COG2391	methyltransferase activity
IG196_28735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG196_28740	COG4654	Cytochrome c, class I
IG196_28770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_28785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IG196_28825	COG1022	Amp-dependent synthetase and ligase
IG196_28830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_28840	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_28880	COG2252	PERMEase
IG196_28950	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_28990	COG1940	carbohydrate kinase activity
IG196_28995	COG1129	ABC transporter
IG196_29000	COG4214	carbohydrate transport
IG196_29005	COG4213	ABC transporter substrate-binding protein
IG196_29015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_29025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IG196_29030	COG0022	dehydrogenase e1 component
IG196_29040	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_29045	COG0583	DNA-binding transcription factor activity
IG196_29060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_29075	COG1024	Enoyl-CoA hydratase
IG196_29080	COG1960	acyl-CoA dehydrogenase activity
IG196_29100	COG0203	ribosomal protein L17
IG196_29105	COG0202	RNA polymerase activity
IG196_29110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IG196_29115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IG196_29120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IG196_29125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IG196_29130	COG0201	protein transport
IG196_29135	COG0200	Binds to the 23S rRNA
IG196_29140	COG1841	ribosomal large subunit assembly
IG196_29145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IG196_29150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IG196_29155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IG196_29160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IG196_29165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IG196_29170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IG196_29175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IG196_29180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IG196_29200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IG196_29205	COG0783	Belongs to the Dps family
IG196_29400	COG4770	biotin carboxylase activity
IG196_29405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_29410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_29415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IG196_29465	COG1280	lysine exporter protein (LysE YggA)
IG196_29470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IG196_29475	COG1090	epimerase
IG196_29485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IG196_29490	COG0343	queuine tRNA-ribosyltransferase activity
IG196_29550	COG0284	orotidine-5'-phosphate decarboxylase activity
IG196_29565	COG1214	PFAM Peptidase M22, glycoprotease
IG196_29575	COG1349	DNA-binding transcription factor activity
IG196_29580	COG0494	nUDIX hydrolase
IG196_29585	COG2027	D-alanyl-D-alanine carboxypeptidase
IG196_29595	COG0009	L-threonylcarbamoyladenylate synthase
IG196_29600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IG196_29605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IG196_29615	COG3620	sequence-specific DNA binding
IG196_29620	COG3550	peptidyl-serine autophosphorylation
IG196_29630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IG196_29640	COG1522	sequence-specific DNA binding
IG196_29645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IG196_29655	COG0469	pyruvate kinase activity
IG196_29660	COG0126	phosphoglycerate kinase activity
IG196_29680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_29710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG196_29720	COG0242	peptide deformylase activity
IG196_29730	COG0758	DNA mediated transformation
IG196_29735	COG2922	Belongs to the Smg family
IG196_29745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IG196_29750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IG196_29755	COG1862	Preprotein translocase
IG196_29765	COG1522	sequence-specific DNA binding
IG196_29800	COG0765	amino acid transport
IG196_29805	COG2814	Major facilitator Superfamily
IG196_29815	COG1845	cytochrome c oxidase, subunit III
IG196_29825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG196_29830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG196_29855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_29885	COG0251	oxidation-reduction process
IG196_29895	COG3622	Belongs to the hyi family
IG196_29900	COG0235	Class ii aldolase
IG196_29905	COG3395	kinase activity
IG196_29910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_29915	COG2084	Dehydrogenase
IG196_29920	COG2271	Major facilitator Superfamily
IG196_29925	COG2186	Transcriptional regulator
IG196_29935	COG1522	sequence-specific DNA binding
IG196_29965	COG4566	intracellular signal transduction
IG196_29985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IG196_29995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG196_30000	COG1595	DNA-templated transcription, initiation
IG196_30020	COG0625	glutathione transferase activity
IG196_30030	COG4772	TonB-dependent receptor
IG196_30050	COG0861	Integral membrane protein TerC family
IG196_30060	COG1950	PFAM Membrane protein of
IG196_30065	COG4783	chaperone-mediated protein folding
IG196_30070	COG0315	cyclic pyranopterin monophosphate synthase activity
IG196_30125	COG1716	ATPase activity
IG196_30130	COG0631	protein serine/threonine phosphatase activity
IG196_30135	COG0861	Integral membrane protein TerC family
IG196_30140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IG196_30145	COG0045	succinate-CoA ligase (ADP-forming) activity
IG196_30150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IG196_30155	COG0427	acetyl-CoA hydrolase
IG196_30160	COG3781	membrane
IG196_30170	COG4682	membrane
IG196_30180	COG2137	regulation of response to DNA damage stimulus
IG196_30185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IG196_30200	COG0642	Histidine kinase
IG196_30215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IG196_30215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IG196_30235	COG0583	DNA-binding transcription factor activity
IG196_30240	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_30265	COG1960	acyl-CoA dehydrogenase activity
IG196_30275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IG196_30285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IG196_30290	COG1522	sequence-specific DNA binding
IG196_30300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IG196_30305	COG0513	Belongs to the DEAD box helicase family
IG196_30335	COG0697	spore germination
IG196_30345	COG1802	Transcriptional regulator
IG196_30360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_30385	COG1473	amidohydrolase
IG196_30390	COG1741	Belongs to the pirin family
IG196_30400	COG0583	DNA-binding transcription factor activity
IG196_30405	COG1047	Peptidyl-prolyl cis-trans
IG196_30410	COG3025	triphosphatase activity
IG196_30455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IG196_30460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IG196_30465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IG196_30480	COG0006	proline dipeptidase activity
IG196_30505	COG4953	penicillin-binding protein 1C
IG196_30510	COG2373	Large extracellular alpha-helical protein
IG196_30535	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_30555	COG0280	phosphate acetyltransferase
IG196_30555	COG0281	malic enzyme
IG196_30575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IG196_30580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG196_30585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IG196_30595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IG196_30610	COG2814	Major facilitator Superfamily
IG196_30615	COG2267	carboxylic ester hydrolase activity
IG196_30635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_30640	COG1739	Uncharacterized protein family UPF0029
IG196_30645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_30645	COG2813	Specifically methylates the guanine in position
IG196_30650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_30655	COG2119	membrane
IG196_30660	COG0724	RNA recognition motif
IG196_30665	COG0300	oxidoreductase activity
IG196_30675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IG196_30700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IG196_30705	COG0706	membrane insertase activity
IG196_30710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IG196_30715	COG0594	ribonuclease P activity
IG196_30720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IG196_30725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IG196_30730	COG0592	DNA-directed DNA polymerase activity
IG196_30765	COG1408	metallophosphoesterase
IG196_30775	COG0392	lysyltransferase activity
IG196_30780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_30785	COG3568	Endonuclease Exonuclease Phosphatase
IG196_30810	COG0454	-acetyltransferase
IG196_30810	COG0456	acetyltransferase
IG196_30815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG196_30840	COG1472	Belongs to the glycosyl hydrolase 3 family
IG196_30855	COG2205	protein histidine kinase activity
IG196_30860	COG0745	RESPONSE REGULATOR receiver
IG196_30875	COG2608	mercury ion transmembrane transporter activity
IG196_30880	COG2217	Heavy metal translocating P-type atpase
IG196_30905	COG0745	RESPONSE REGULATOR receiver
IG196_30910	COG0642	Histidine kinase
IG196_30915	COG0456	acetyltransferase
IG196_30925	COG1902	pentaerythritol trinitrate reductase activity
IG196_30935	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_30945	COG1024	Enoyl-CoA hydratase
IG196_30950	COG1024	Enoyl-CoA hydratase
IG196_30955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_30975	COG0445	tRNA wobble uridine modification
IG196_30980	COG0357	Ribosomal RNA small subunit methyltransferase G
IG196_30990	COG1192	Involved in chromosome partitioning
IG196_31010	COG0277	FAD linked oxidase domain protein
IG196_31020	COG2096	Adenosyltransferase
IG196_31110	COG0583	DNA-binding transcription factor activity
IG196_31130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IG196_31135	COG2894	cell division
IG196_31140	COG0850	regulation of cytokinetic process
IG196_31145	COG2233	PERMEase
IG196_31150	COG2050	protein possibly involved in aromatic compounds catabolism
IG196_31180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_31195	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_31205	COG3246	L-lysine catabolic process to acetate
IG196_31230	COG1309	transcriptional regulator
IG196_31235	COG1819	glycosyl
IG196_31240	COG3284	Transcriptional regulator
IG196_31245	COG1942	4-Oxalocrotonate Tautomerase
IG196_31250	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_31305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG196_31335	COG1959	2 iron, 2 sulfur cluster binding
IG196_31355	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG196_31360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_31365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_31370	COG1116	anion transmembrane transporter activity
IG196_31370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_31385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG196_31395	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IG196_31420	COG0583	DNA-binding transcription factor activity
IG196_31425	COG1960	acyl-CoA dehydrogenase activity
IG196_31430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_31445	COG0583	DNA-binding transcription factor activity
IG196_31455	COG1473	amidohydrolase
IG196_31460	COG1760	l-serine dehydratase
IG196_31475	COG1573	uracil-dna glycosylase
IG196_31490	COG0583	DNA-binding transcription factor activity
IG196_31515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_31525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG196_31535	COG1129	ABC transporter
IG196_31540	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_31550	COG0683	leucine binding
IG196_31570	COG2066	Belongs to the glutaminase family
IG196_31585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG196_31595	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IG196_31605	COG0700	Nucleoside recognition
IG196_31610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_31625	COG0410	ABC transporter
IG196_31645	COG0683	leucine binding
IG196_31650	COG0633	Ferredoxin
IG196_31720	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IG196_31730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_31735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_31750	COG1070	Carbohydrate kinase
IG196_31780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_31785	COG1116	anion transmembrane transporter activity
IG196_31795	COG2986	histidine ammonia-lyase
IG196_31800	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IG196_31815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_31820	COG0765	amino acid transport
IG196_31830	COG1228	amidohydrolase
IG196_31865	COG5380	lipid catabolic process
IG196_31870	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IG196_31875	COG0646	methionine synthase
IG196_31875	COG1410	methionine synthase
IG196_31900	COG1309	transcriptional regulator
IG196_31930	COG0683	leucine binding
IG196_31950	COG1335	isochorismatase