locus-tag	class	description
E5CHR_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5CHR_00002	COG0592	DNA-directed DNA polymerase activity
E5CHR_00007	COG1408	metallophosphoesterase
E5CHR_00010	COG0392	lysyltransferase activity
E5CHR_00011	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_00012	COG3568	Endonuclease Exonuclease Phosphatase
E5CHR_00015	COG4948	Mandelate Racemase Muconate Lactonizing
E5CHR_00017	COG4149	molybdate abc transporter
E5CHR_00018	COG3842	ATPase activity
E5CHR_00021	COG2186	Transcriptional regulator
E5CHR_00023	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5CHR_00028	COG2205	protein histidine kinase activity
E5CHR_00029	COG0745	RESPONSE REGULATOR receiver
E5CHR_00031	COG2608	mercury ion transmembrane transporter activity
E5CHR_00033	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5CHR_00034	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5CHR_00038	COG0745	RESPONSE REGULATOR receiver
E5CHR_00039	COG0642	Histidine kinase
E5CHR_00040	COG1902	pentaerythritol trinitrate reductase activity
E5CHR_00043	COG5487	UPF0391 membrane protein
E5CHR_00044	COG0445	tRNA wobble uridine modification
E5CHR_00045	COG0357	Ribosomal RNA small subunit methyltransferase G
E5CHR_00046	COG1280	lysine exporter protein (LysE YggA)
E5CHR_00047	COG1192	Involved in chromosome partitioning
E5CHR_00051	COG0277	FAD linked oxidase domain protein
E5CHR_00052	COG2096	Adenosyltransferase
E5CHR_00057	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E5CHR_00059	COG0850	regulation of cytokinetic process
E5CHR_00061	COG2233	PERMEase
E5CHR_00062	COG2050	protein possibly involved in aromatic compounds catabolism
E5CHR_00067	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5CHR_00074	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5CHR_00079	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5CHR_00080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5CHR_00082	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5CHR_00083	COG0583	DNA-binding transcription factor activity
E5CHR_00084	COG0235	Class ii aldolase
E5CHR_00086	COG1024	Enoyl-CoA hydratase
E5CHR_00092	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5CHR_00103	COG0740	serine-type endopeptidase activity
E5CHR_00105	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00110	COG0477	Major facilitator Superfamily
E5CHR_00111	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5CHR_00112	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5CHR_00113	COG1845	cytochrome c oxidase, subunit III
E5CHR_00114	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5CHR_00117	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E5CHR_00120	COG0004	ammonium transporteR
E5CHR_00122	COG2207	Transcriptional regulator
E5CHR_00123	COG2223	nitrite transmembrane transporter activity
E5CHR_00125	COG2205	protein histidine kinase activity
E5CHR_00126	COG4789	Type iii secretion
E5CHR_00132	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5CHR_00133	COG0450	alkyl hydroperoxide reductase
E5CHR_00134	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5CHR_00139	COG0640	Transcriptional regulator
E5CHR_00143	COG0583	DNA-binding transcription factor activity
E5CHR_00144	COG1960	acyl-CoA dehydrogenase activity
E5CHR_00145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_00153	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5CHR_00154	COG0700	Nucleoside recognition
E5CHR_00160	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E5CHR_00162	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5CHR_00163	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5CHR_00171	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5CHR_00176	COG1228	amidohydrolase
E5CHR_00184	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5CHR_00185	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5CHR_00186	COG4149	molybdate abc transporter
E5CHR_00192	COG0583	DNA-binding transcription factor activity
E5CHR_00196	COG0646	methionine synthase
E5CHR_00196	COG1410	methionine synthase
E5CHR_00201	COG1309	transcriptional regulator
E5CHR_00211	COG1335	isochorismatase
E5CHR_00212	COG2080	2 iron, 2 sulfur cluster binding
E5CHR_00213	COG2010	Cytochrome c
E5CHR_00213	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5CHR_00215	COG2721	sulfolactate sulfo-lyase activity
E5CHR_00219	COG4948	Mandelate Racemase Muconate Lactonizing
E5CHR_00220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5CHR_00222	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_00224	COG1126	abc transporter atp-binding protein
E5CHR_00225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5CHR_00227	COG0765	amino acid transport
E5CHR_00230	COG0606	chelatase, subunit chli
E5CHR_00232	COG0347	Belongs to the P(II) protein family
E5CHR_00233	COG0004	ammonium transporteR
E5CHR_00235	COG0277	FAD linked oxidase domain protein
E5CHR_00236	COG0247	lactate metabolic process
E5CHR_00238	COG0386	Belongs to the glutathione peroxidase family
E5CHR_00241	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5CHR_00242	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5CHR_00244	COG0129	dihydroxy-acid dehydratase activity
E5CHR_00246	COG3971	2-oxopent-4-enoate hydratase activity
E5CHR_00251	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_00254	COG1846	Transcriptional regulator
E5CHR_00258	COG2974	May be involved in recombination
E5CHR_00264	COG0745	RESPONSE REGULATOR receiver
E5CHR_00265	COG0579	oxidoreductase
E5CHR_00277	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5CHR_00278	COG1335	isochorismatase
E5CHR_00280	COG1335	isochorismatase
E5CHR_00286	COG0583	DNA-binding transcription factor activity
E5CHR_00289	COG2072	flavoprotein involved in K transport
E5CHR_00290	COG0708	Exodeoxyribonuclease III
E5CHR_00291	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5CHR_00293	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5CHR_00294	COG0154	amidase activity
E5CHR_00295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5CHR_00296	COG1077	Cell shape determining protein MreB Mrl
E5CHR_00299	COG0768	penicillin binding
E5CHR_00301	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5CHR_00305	COG0622	Phosphoesterase
E5CHR_00306	COG2095	MarC family integral membrane protein
E5CHR_00307	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00309	COG0412	Dienelactone hydrolase
E5CHR_00310	COG0583	DNA-binding transcription factor activity
E5CHR_00313	COG0598	Magnesium transport protein CorA
E5CHR_00317	COG3411	Ferredoxin
E5CHR_00318	COG2945	thiolester hydrolase activity
E5CHR_00319	COG1686	Belongs to the peptidase S11 family
E5CHR_00320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5CHR_00321	COG0049	tRNA binding
E5CHR_00322	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5CHR_00323	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5CHR_00324	COG0051	transcription antitermination factor activity, RNA binding
E5CHR_00325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5CHR_00326	COG0088	Forms part of the polypeptide exit tunnel
E5CHR_00327	COG0089	rRNA binding
E5CHR_00328	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5CHR_00329	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5CHR_00330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5CHR_00331	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5CHR_00332	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5CHR_00333	COG0255	Belongs to the universal ribosomal protein uL29 family
E5CHR_00334	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5CHR_00335	COG0678	peroxiredoxin activity
E5CHR_00339	COG3909	cytochrome
E5CHR_00340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5CHR_00343	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5CHR_00344	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5CHR_00346	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5CHR_00347	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5CHR_00348	COG0596	Alpha beta hydrolase
E5CHR_00349	COG0280	phosphate acetyltransferase
E5CHR_00349	COG0281	malic enzyme
E5CHR_00350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5CHR_00351	COG1301	dicarboxylic acid transport
E5CHR_00352	COG1252	NADH dehydrogenase
E5CHR_00353	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5CHR_00354	COG0183	Belongs to the thiolase family
E5CHR_00355	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00356	COG1271	oxidase subunit
E5CHR_00357	COG1294	oxidase, subunit
E5CHR_00362	COG2205	protein histidine kinase activity
E5CHR_00363	COG2130	NADP-dependent
E5CHR_00365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E5CHR_00366	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_00368	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5CHR_00369	COG0321	lipoyl(octanoyl) transferase activity
E5CHR_00370	COG2921	Belongs to the UPF0250 family
E5CHR_00371	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5CHR_00373	COG0356	it plays a direct role in the translocation of protons across the membrane
E5CHR_00375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5CHR_00376	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5CHR_00377	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5CHR_00378	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5CHR_00379	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5CHR_00380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5CHR_00386	COG1129	ABC transporter
E5CHR_00387	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5CHR_00388	COG1879	ABC-type sugar transport system periplasmic component
E5CHR_00389	COG0673	inositol 2-dehydrogenase activity
E5CHR_00390	COG0516	GMP reductase activity
E5CHR_00390	COG0517	IMP dehydrogenase activity
E5CHR_00392	COG1881	PFAM PEBP family protein
E5CHR_00393	COG3588	fructose-bisphosphate aldolase
E5CHR_00394	COG2902	Dehydrogenase
E5CHR_00406	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5CHR_00407	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5CHR_00417	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00418	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00420	COG3842	ATPase activity
E5CHR_00421	COG0395	ABC-type sugar transport system, permease component
E5CHR_00424	COG1233	COG1233 Phytoene dehydrogenase and related
E5CHR_00425	COG1609	Transcriptional regulator
E5CHR_00430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5CHR_00431	COG0792	nuclease activity
E5CHR_00432	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5CHR_00433	COG2823	Periplasmic or secreted lipoprotein
E5CHR_00434	COG2084	Dehydrogenase
E5CHR_00438	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5CHR_00447	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5CHR_00447	COG2124	cytochrome p450
E5CHR_00448	COG1309	transcriptional regulator
E5CHR_00449	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5CHR_00454	COG2376	Dihydroxyacetone kinase
E5CHR_00458	COG1175	transmembrane transport
E5CHR_00459	COG0395	ABC-type sugar transport system, permease component
E5CHR_00460	COG3842	ATPase activity
E5CHR_00461	COG0445	tRNA wobble uridine modification
E5CHR_00462	COG1346	cytolysis
E5CHR_00463	COG1380	Effector of murein hydrolase LrgA
E5CHR_00464	COG0277	FAD linked oxidase domain protein
E5CHR_00482	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5CHR_00492	COG0343	queuine tRNA-ribosyltransferase activity
E5CHR_00493	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5CHR_00494	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5CHR_00498	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_00500	COG1960	acyl-CoA dehydrogenase activity
E5CHR_00501	COG1024	Enoyl-CoA hydratase
E5CHR_00504	COG0596	Alpha beta hydrolase
E5CHR_00505	COG0583	DNA-binding transcription factor activity
E5CHR_00507	COG0783	Belongs to the Dps family
E5CHR_00508	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5CHR_00511	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5CHR_00512	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5CHR_00513	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5CHR_00514	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5CHR_00515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5CHR_00516	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5CHR_00517	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5CHR_00518	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5CHR_00519	COG1841	ribosomal large subunit assembly
E5CHR_00520	COG0200	Binds to the 23S rRNA
E5CHR_00521	COG0201	protein transport
E5CHR_00522	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5CHR_00523	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5CHR_00524	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5CHR_00525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5CHR_00526	COG0202	RNA polymerase activity
E5CHR_00527	COG0203	ribosomal protein L17
E5CHR_00529	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5CHR_00529	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5CHR_00529	COG0506	proline dehydrogenase activity
E5CHR_00533	COG1960	acyl-CoA dehydrogenase activity
E5CHR_00534	COG1024	Enoyl-CoA hydratase
E5CHR_00537	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5CHR_00541	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00543	COG0022	dehydrogenase e1 component
E5CHR_00544	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5CHR_00547	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5CHR_00548	COG2814	Major facilitator Superfamily
E5CHR_00551	COG2814	Major facilitator Superfamily
E5CHR_00553	COG1686	Belongs to the peptidase S11 family
E5CHR_00558	COG1595	DNA-templated transcription, initiation
E5CHR_00563	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_00566	COG0667	Aldo Keto reductase
E5CHR_00567	COG0346	lactoylglutathione lyase activity
E5CHR_00575	COG4213	ABC transporter substrate-binding protein
E5CHR_00576	COG4214	carbohydrate transport
E5CHR_00577	COG1129	ABC transporter
E5CHR_00585	COG0477	Major facilitator Superfamily
E5CHR_00592	COG1022	Amp-dependent synthetase and ligase
E5CHR_00593	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5CHR_00595	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5CHR_00601	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5CHR_00602	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E5CHR_00603	COG2205	protein histidine kinase activity
E5CHR_00604	COG0745	RESPONSE REGULATOR receiver
E5CHR_00605	COG1187	pseudouridine synthase activity
E5CHR_00607	COG0745	RESPONSE REGULATOR receiver
E5CHR_00608	COG0642	Histidine kinase
E5CHR_00610	COG0326	Molecular chaperone. Has ATPase activity
E5CHR_00611	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_00612	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_00613	COG1960	acyl-CoA dehydrogenase activity
E5CHR_00614	COG0583	DNA-binding transcription factor activity
E5CHR_00616	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5CHR_00618	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_00620	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_00621	COG2267	carboxylic ester hydrolase activity
E5CHR_00624	COG0183	Belongs to the thiolase family
E5CHR_00628	COG1764	response to oxidative stress
E5CHR_00629	COG1846	Transcriptional regulator
E5CHR_00631	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5CHR_00632	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E5CHR_00636	COG0724	RNA recognition motif
E5CHR_00637	COG3530	Putative quorum-sensing-regulated virulence factor
E5CHR_00638	COG0513	Belongs to the DEAD box helicase family
E5CHR_00640	COG0842	Transport permease protein
E5CHR_00641	COG1131	(ABC) transporter
E5CHR_00642	COG0583	DNA-binding transcription factor activity
E5CHR_00643	COG0625	glutathione transferase activity
E5CHR_00645	COG2124	cytochrome p450
E5CHR_00646	COG0640	Transcriptional regulator
E5CHR_00647	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5CHR_00651	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5CHR_00652	COG4208	sulfate ABC transporter
E5CHR_00654	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5CHR_00659	COG1652	LysM domain
E5CHR_00660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E5CHR_00661	COG2733	membrane
E5CHR_00662	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5CHR_00663	COG1473	amidohydrolase
E5CHR_00666	COG0243	molybdopterin cofactor binding
E5CHR_00669	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_00682	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5CHR_00683	COG4106	trans-aconitate 2-methyltransferase activity
E5CHR_00686	COG2076	Multidrug Resistance protein
E5CHR_00688	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5CHR_00689	COG1086	Polysaccharide biosynthesis protein
E5CHR_00702	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5CHR_00705	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E5CHR_00708	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5CHR_00712	COG0662	Cupin 2, conserved barrel domain protein
E5CHR_00712	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E5CHR_00713	COG1216	Glycosyl transferase, family 2
E5CHR_00713	COG0438	transferase activity, transferring glycosyl groups
E5CHR_00716	COG2755	lipolytic protein G-D-S-L family
E5CHR_00716	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5CHR_00718	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5CHR_00719	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5CHR_00721	COG0753	catalase activity
E5CHR_00724	COG2119	membrane
E5CHR_00727	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5CHR_00730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E5CHR_00731	COG1309	transcriptional regulator
E5CHR_00732	COG2309	aminopeptidase activity
E5CHR_00740	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5CHR_00743	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5CHR_00748	COG1137	ATPase activity
E5CHR_00755	COG3064	Membrane
E5CHR_00759	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E5CHR_00760	COG2721	sulfolactate sulfo-lyase activity
E5CHR_00761	COG2186	Transcriptional regulator
E5CHR_00762	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00764	COG0765	amino acid transport
E5CHR_00765	COG0765	amino acid transport
E5CHR_00768	COG4948	Mandelate Racemase Muconate Lactonizing
E5CHR_00772	COG2188	Transcriptional regulator
E5CHR_00779	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5CHR_00780	COG0066	3-isopropylmalate dehydratase activity
E5CHR_00786	COG1053	succinate dehydrogenase
E5CHR_00786	COG0431	NADPH-dependent FMN reductase
E5CHR_00786	COG3976	FMN-binding domain protein
E5CHR_00790	COG1960	acyl-CoA dehydrogenase activity
E5CHR_00792	COG1024	Enoyl-CoA hydratase
E5CHR_00792	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5CHR_00793	COG2852	Protein conserved in bacteria
E5CHR_00794	COG0183	Belongs to the thiolase family
E5CHR_00798	COG1024	Enoyl-CoA hydratase
E5CHR_00799	COG1607	acyl-coa hydrolase
E5CHR_00800	COG5265	(ABC) transporter
E5CHR_00801	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5CHR_00802	COG0583	DNA-binding transcription factor activity
E5CHR_00804	COG0765	amino acid transport
E5CHR_00805	COG0765	amino acid transport
E5CHR_00806	COG1126	abc transporter atp-binding protein
E5CHR_00807	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5CHR_00810	COG1280	lysine exporter protein (LysE YggA)
E5CHR_00812	COG2003	Belongs to the UPF0758 family
E5CHR_00814	COG0418	dihydroorotase activity
E5CHR_00821	COG1414	Transcriptional regulator
E5CHR_00822	COG0501	Belongs to the peptidase M48B family
E5CHR_00823	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E5CHR_00830	COG1187	pseudouridine synthase activity
E5CHR_00831	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5CHR_00833	COG1030	water channel activity
E5CHR_00834	COG0330	HflC and HflK could
E5CHR_00835	COG0598	Magnesium transport protein CorA
E5CHR_00838	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5CHR_00840	COG2807	transmembrane transport
E5CHR_00843	COG2175	clavaminate synthase activity
E5CHR_00846	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5CHR_00849	COG2175	clavaminate synthase activity
E5CHR_00858	COG0596	Alpha beta hydrolase
E5CHR_00858	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5CHR_00860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5CHR_00862	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_00864	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5CHR_00867	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5CHR_00868	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5CHR_00869	COG0523	cobalamin synthesis protein
E5CHR_00872	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5CHR_00873	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5CHR_00874	COG2001	Belongs to the MraZ family
E5CHR_00875	COG0275	rRNA processing
E5CHR_00878	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5CHR_00879	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5CHR_00880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5CHR_00881	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5CHR_00882	COG0772	Belongs to the SEDS family
E5CHR_00883	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5CHR_00884	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5CHR_00885	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5CHR_00886	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5CHR_00888	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5CHR_00889	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E5CHR_00893	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5CHR_00894	COG0575	Belongs to the CDS family
E5CHR_00896	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5CHR_00897	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5CHR_00900	COG3150	esterase
E5CHR_00901	COG2197	response regulator
E5CHR_00903	COG0772	Belongs to the SEDS family
E5CHR_00904	COG0312	modulator of DNA gyrase
E5CHR_00905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5CHR_00907	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5CHR_00910	COG0511	ligase activity, forming carbon-carbon bonds
E5CHR_00911	COG0439	Biotin carboxylase
E5CHR_00912	COG2264	protein methyltransferase activity
E5CHR_00914	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5CHR_00916	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5CHR_00923	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5CHR_00924	COG2943	transferase activity, transferring hexosyl groups
E5CHR_00924	COG3416	Protein conserved in bacteria
E5CHR_00926	COG2204	response regulator
E5CHR_00928	COG2205	protein histidine kinase activity
E5CHR_00929	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5CHR_00931	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5CHR_00932	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5CHR_00939	COG0037	tRNA processing
E5CHR_00941	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_00943	COG2175	clavaminate synthase activity
E5CHR_00945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5CHR_00946	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_00951	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5CHR_00953	COG0617	tRNA 3'-terminal CCA addition
E5CHR_00956	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5CHR_00957	COG0583	DNA-binding transcription factor activity
E5CHR_00959	COG2200	EAL domain
E5CHR_00960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5CHR_00963	COG0110	maltose O-acetyltransferase activity
E5CHR_00964	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5CHR_00965	COG1522	sequence-specific DNA binding
E5CHR_00967	COG1254	Belongs to the acylphosphatase family
E5CHR_00973	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_00974	COG0183	Belongs to the thiolase family
E5CHR_00978	COG0515	serine threonine protein kinase
E5CHR_00978	COG2815	serine threonine protein kinase
E5CHR_00980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5CHR_00981	COG4597	amino acid ABC transporter
E5CHR_00982	COG0765	amino acid transport
E5CHR_00983	COG1126	abc transporter atp-binding protein
E5CHR_00989	COG2072	flavoprotein involved in K transport
E5CHR_00992	COG0129	dihydroxy-acid dehydratase activity
E5CHR_00995	COG3386	PFAM SMP-30 Gluconolaconase
E5CHR_00997	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_00998	COG1879	ABC-type sugar transport system periplasmic component
E5CHR_01001	COG4214	carbohydrate transport
E5CHR_01002	COG1129	ABC transporter
E5CHR_01003	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5CHR_01004	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5CHR_01010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5CHR_01010	COG0189	ligase activity
E5CHR_01011	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5CHR_01011	COG0189	ligase activity
E5CHR_01012	COG1132	(ABC) transporter
E5CHR_01014	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5CHR_01015	COG4178	(ABC) transporter
E5CHR_01017	COG1459	type II secretion system
E5CHR_01026	COG4970	Tfp pilus assembly protein FimT
E5CHR_01029	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5CHR_01031	COG1765	OsmC-like protein
E5CHR_01032	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E5CHR_01035	COG1473	amidohydrolase
E5CHR_01036	COG4166	transmembrane transport
E5CHR_01037	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5CHR_01038	COG0444	Belongs to the ABC transporter superfamily
E5CHR_01039	COG4608	Belongs to the ABC transporter superfamily
E5CHR_01040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5CHR_01041	COG1840	ABC-type Fe3 transport system, periplasmic component
E5CHR_01043	COG3842	ATPase activity
E5CHR_01046	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5CHR_01047	COG0166	Belongs to the GPI family
E5CHR_01048	COG0439	Biotin carboxylase
E5CHR_01049	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_01052	COG1802	Transcriptional regulator
E5CHR_01055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5CHR_01058	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5CHR_01059	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E5CHR_01060	COG0745	RESPONSE REGULATOR receiver
E5CHR_01061	COG5002	protein histidine kinase activity
E5CHR_01062	COG0459	protein refolding
E5CHR_01063	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5CHR_01064	COG2186	Transcriptional regulator
E5CHR_01065	COG2807	transmembrane transport
E5CHR_01066	COG0456	acetyltransferase
E5CHR_01070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_01071	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_01073	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_01078	COG2207	Transcriptional regulator
E5CHR_01080	COG0625	glutathione transferase activity
E5CHR_01084	COG4772	TonB-dependent receptor
E5CHR_01086	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5CHR_01088	COG1560	Kdo2-lipid A biosynthetic process
E5CHR_01090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5CHR_01092	COG1333	cytochrome c biogenesis protein
E5CHR_01093	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5CHR_01094	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5CHR_01095	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E5CHR_01098	COG1965	Belongs to the frataxin family
E5CHR_01105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5CHR_01107	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E5CHR_01112	COG0067	glutamate synthase
E5CHR_01112	COG0069	glutamate synthase activity
E5CHR_01112	COG0070	glutamate synthase
E5CHR_01114	COG1127	ABC transporter
E5CHR_01115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5CHR_01116	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5CHR_01120	COG1131	(ABC) transporter
E5CHR_01121	COG0842	Transport permease protein
E5CHR_01122	COG5007	Belongs to the BolA IbaG family
E5CHR_01123	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5CHR_01124	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5CHR_01125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5CHR_01127	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5CHR_01128	COG0131	Imidazoleglycerol-phosphate dehydratase
E5CHR_01130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5CHR_01132	COG1301	dicarboxylic acid transport
E5CHR_01134	COG0107	imidazoleglycerol-phosphate synthase activity
E5CHR_01135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5CHR_01136	COG0140	phosphoribosyl-ATP diphosphatase activity
E5CHR_01138	COG0537	adenosine 5'-monophosphoramidase activity
E5CHR_01139	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5CHR_01140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5CHR_01141	COG0805	protein transport
E5CHR_01142	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_01143	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5CHR_01144	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5CHR_01145	COG1970	mechanosensitive ion channel activity
E5CHR_01146	COG0723	plastoquinol--plastocyanin reductase activity
E5CHR_01147	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5CHR_01148	COG2857	Cytochrome c1
E5CHR_01149	COG0625	glutathione transferase activity
E5CHR_01150	COG2969	positive regulation of protein catabolic process
E5CHR_01152	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_01154	COG1309	transcriptional regulator
E5CHR_01157	COG0653	protein targeting
E5CHR_01158	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5CHR_01160	COG0494	nUDIX hydrolase
E5CHR_01161	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5CHR_01162	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E5CHR_01164	COG1696	Membrane protein involved in D-alanine export
E5CHR_01170	COG0142	geranyltranstransferase activity
E5CHR_01171	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5CHR_01172	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5CHR_01173	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5CHR_01174	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5CHR_01176	COG0494	nUDIX hydrolase
E5CHR_01177	COG0442	prolyl-tRNA aminoacylation
E5CHR_01178	COG0741	lytic transglycosylase activity
E5CHR_01179	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5CHR_01181	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5CHR_01182	COG2890	protein-(glutamine-N5) methyltransferase activity
E5CHR_01183	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5CHR_01184	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5CHR_01186	COG3264	Mechanosensitive ion channel
E5CHR_01186	COG1511	domain protein
E5CHR_01187	COG0584	glycerophosphoryl diester phosphodiesterase
E5CHR_01188	COG3842	ATPase activity
E5CHR_01189	COG0395	ABC-type sugar transport system, permease component
E5CHR_01190	COG1175	transmembrane transport
E5CHR_01192	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5CHR_01196	COG2226	methyltransferase
E5CHR_01199	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5CHR_01200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5CHR_01201	COG3842	ATPase activity
E5CHR_01202	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5CHR_01203	COG1177	transmembrane transport
E5CHR_01206	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5CHR_01211	COG3568	Endonuclease Exonuclease Phosphatase
E5CHR_01212	COG0302	gtp cyclohydrolase
E5CHR_01214	COG2076	Multidrug Resistance protein
E5CHR_01222	COG4585	Histidine kinase
E5CHR_01223	COG2197	response regulator
E5CHR_01225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5CHR_01226	COG0793	Belongs to the peptidase S41A family
E5CHR_01227	COG0588	phosphoglycerate mutase activity
E5CHR_01228	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5CHR_01230	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5CHR_01231	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5CHR_01233	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5CHR_01238	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5CHR_01239	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5CHR_01240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E5CHR_01241	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5CHR_01246	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5CHR_01246	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5CHR_01247	COG3132	Protein of unknown function, DUF480
E5CHR_01250	COG0489	protein tyrosine kinase activity
E5CHR_01251	COG2223	nitrite transmembrane transporter activity
E5CHR_01253	COG3383	formate dehydrogenase (NAD+) activity
E5CHR_01257	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5CHR_01258	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5CHR_01259	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_01262	COG2003	Belongs to the UPF0758 family
E5CHR_01263	COG1047	Peptidyl-prolyl cis-trans
E5CHR_01264	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5CHR_01265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5CHR_01267	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5CHR_01276	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5CHR_01277	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5CHR_01292	COG3162	membrane
E5CHR_01294	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5CHR_01294	COG0045	succinate-CoA ligase (ADP-forming) activity
E5CHR_01294	COG1042	CoA-binding domain protein
E5CHR_01295	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5CHR_01296	COG0589	response to stress
E5CHR_01297	COG2217	Heavy metal translocating P-type atpase
E5CHR_01299	COG3278	Belongs to the heme-copper respiratory oxidase family
E5CHR_01306	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5CHR_01307	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5CHR_01310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5CHR_01312	COG0671	phosphoesterase, PA-phosphatase related
E5CHR_01315	COG0045	succinate-CoA ligase (ADP-forming) activity
E5CHR_01315	COG1042	CoA-binding domain protein
E5CHR_01315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5CHR_01321	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E5CHR_01322	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5CHR_01323	COG0784	Response regulator, receiver
E5CHR_01323	COG4191	Histidine kinase
E5CHR_01328	COG0071	Belongs to the small heat shock protein (HSP20) family
E5CHR_01338	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_01339	COG0589	response to stress
E5CHR_01340	COG0589	response to stress
E5CHR_01343	COG0589	response to stress
E5CHR_01347	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_01349	COG1914	H( )-stimulated, divalent metal cation uptake system
E5CHR_01350	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E5CHR_01351	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5CHR_01354	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_01357	COG0242	peptide deformylase activity
E5CHR_01360	COG4638	Rieske (2fe-2S)
E5CHR_01364	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5CHR_01368	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5CHR_01377	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_01385	COG0438	transferase activity, transferring glycosyl groups
E5CHR_01392	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5CHR_01395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5CHR_01396	COG2175	clavaminate synthase activity
E5CHR_01402	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_01403	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5CHR_01403	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5CHR_01404	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5CHR_01404	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5CHR_01405	COG1024	Enoyl-CoA hydratase
E5CHR_01409	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5CHR_01412	COG1335	isochorismatase
E5CHR_01413	COG1802	Transcriptional regulator
E5CHR_01416	COG2271	Major facilitator Superfamily
E5CHR_01420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5CHR_01424	COG3128	pkhd-type hydroxylase
E5CHR_01425	COG4774	siderophore transport
E5CHR_01426	COG5002	protein histidine kinase activity
E5CHR_01427	COG2197	response regulator
E5CHR_01428	COG0180	Tryptophanyl-tRNA synthetase
E5CHR_01429	COG1994	Peptidase M50
E5CHR_01430	COG0009	L-threonylcarbamoyladenylate synthase
E5CHR_01432	COG0613	PHP domain protein
E5CHR_01434	COG0306	phosphate transporter
E5CHR_01441	COG1129	ABC transporter
E5CHR_01443	COG3540	Alkaline phosphatase
E5CHR_01446	COG1595	DNA-templated transcription, initiation
E5CHR_01448	COG0477	Major facilitator Superfamily
E5CHR_01449	COG0829	nickel cation binding
E5CHR_01457	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E5CHR_01470	COG0163	prenyltransferase activity
E5CHR_01471	COG0523	cobalamin synthesis protein
E5CHR_01472	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5CHR_01472	COG2080	2 iron, 2 sulfur cluster binding
E5CHR_01475	COG0583	DNA-binding transcription factor activity
E5CHR_01476	COG2233	PERMEase
E5CHR_01477	COG0280	phosphate acetyltransferase
E5CHR_01477	COG0281	malic enzyme
E5CHR_01478	COG2084	Dehydrogenase
E5CHR_01479	COG3622	Belongs to the hyi family
E5CHR_01480	COG3960	tartronate-semialdehyde synthase activity
E5CHR_01481	COG0583	DNA-binding transcription factor activity
E5CHR_01484	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5CHR_01485	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_01486	COG0251	oxidation-reduction process
E5CHR_01488	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5CHR_01489	COG3971	2-oxopent-4-enoate hydratase activity
E5CHR_01491	COG3548	integral membrane protein
E5CHR_01499	COG0427	acetyl-CoA hydrolase
E5CHR_01504	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_01505	COG3386	PFAM SMP-30 Gluconolaconase
E5CHR_01506	COG1024	Enoyl-CoA hydratase
E5CHR_01507	COG1609	Transcriptional regulator
E5CHR_01509	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_01510	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_01516	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5CHR_01517	COG0439	Biotin carboxylase
E5CHR_01520	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5CHR_01524	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_01531	COG4221	oxidoreductase activity
E5CHR_01539	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5CHR_01550	COG0628	permease
E5CHR_01551	COG2186	Transcriptional regulator
E5CHR_01552	COG1301	dicarboxylic acid transport
E5CHR_01553	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5CHR_01558	COG0656	L-ascorbic acid biosynthetic process
E5CHR_01559	COG1953	Uracil, thiamine, allantoin
E5CHR_01560	COG2233	PERMEase
E5CHR_01563	COG1953	Uracil, thiamine, allantoin
E5CHR_01567	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5CHR_01570	COG2186	Transcriptional regulator
E5CHR_01591	COG1280	lysine exporter protein (LysE YggA)
E5CHR_01592	COG2133	pyrroloquinoline quinone binding
E5CHR_01594	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5CHR_01595	COG1021	2,3-dihydroxybenzoate-AMP ligase
E5CHR_01602	COG1320	monovalent cation:proton antiporter activity
E5CHR_01603	COG2212	antiporter activity
E5CHR_01605	COG0651	ATP synthesis coupled electron transport
E5CHR_01606	COG1006	Multisubunit Na H antiporter MnhC subunit
E5CHR_01607	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5CHR_01607	COG2111	Na H antiporter
E5CHR_01608	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5CHR_01610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E5CHR_01614	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5CHR_01615	COG0287	Prephenate dehydrogenase
E5CHR_01617	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5CHR_01621	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5CHR_01627	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5CHR_01627	COG4797	methyltransferase
E5CHR_01629	COG1187	pseudouridine synthase activity
E5CHR_01634	COG1058	Belongs to the CinA family
E5CHR_01634	COG1546	Belongs to the CinA family
E5CHR_01635	COG0174	glutamine synthetase
E5CHR_01637	COG3852	Histidine kinase
E5CHR_01638	COG2204	response regulator
E5CHR_01640	COG0708	Exodeoxyribonuclease III
E5CHR_01641	COG1956	GAF domain-containing protein
E5CHR_01648	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5CHR_01654	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5CHR_01655	COG0277	FAD linked oxidase domain protein
E5CHR_01657	COG1295	ribonuclease BN
E5CHR_01658	COG3118	belongs to the thioredoxin family
E5CHR_01667	COG1538	Outer membrane efflux protein
E5CHR_01670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5CHR_01671	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_01674	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5CHR_01675	COG0596	Alpha beta hydrolase
E5CHR_01677	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5CHR_01678	COG2818	Glycosylase
E5CHR_01679	COG2719	SpoVR family
E5CHR_01680	COG2718	Belongs to the UPF0229 family
E5CHR_01681	COG2766	serine protein kinase
E5CHR_01682	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5CHR_01683	COG2186	Transcriptional regulator
E5CHR_01688	COG0673	inositol 2-dehydrogenase activity
E5CHR_01691	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5CHR_01700	COG0484	heat shock protein binding
E5CHR_01701	COG0443	Heat shock 70 kDa protein
E5CHR_01702	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5CHR_01705	COG0688	phosphatidylethanolamine metabolic process
E5CHR_01707	COG2721	sulfolactate sulfo-lyase activity
E5CHR_01708	COG2706	6-phosphogluconolactonase activity
E5CHR_01711	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5CHR_01712	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5CHR_01713	COG2186	Transcriptional regulator
E5CHR_01715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5CHR_01716	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_01721	COG2188	Transcriptional regulator
E5CHR_01722	COG0683	leucine binding
E5CHR_01725	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5CHR_01732	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_01734	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5CHR_01739	COG1137	ATPase activity
E5CHR_01745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5CHR_01749	COG0517	IMP dehydrogenase activity
E5CHR_01749	COG1125	glycine betaine transport
E5CHR_01750	COG2814	Major facilitator Superfamily
E5CHR_01752	COG0358	DNA primase activity
E5CHR_01753	COG1295	ribonuclease BN
E5CHR_01758	COG3237	CsbD-like
E5CHR_01759	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5CHR_01764	COG1611	Belongs to the LOG family
E5CHR_01765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5CHR_01767	COG0322	excinuclease ABC activity
E5CHR_01770	COG0473	3-isopropylmalate dehydrogenase activity
E5CHR_01773	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5CHR_01777	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5CHR_01778	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5CHR_01781	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5CHR_01782	COG0670	Belongs to the BI1 family
E5CHR_01783	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E5CHR_01788	COG3128	pkhd-type hydroxylase
E5CHR_01791	COG1477	protein flavinylation
E5CHR_01797	COG3634	alkyl hydroperoxide reductase activity
E5CHR_01800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5CHR_01803	COG0360	Binds together with S18 to 16S ribosomal RNA
E5CHR_01804	COG2965	DNA replication, synthesis of RNA primer
E5CHR_01805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5CHR_01806	COG0359	binds to the 23S rRNA
E5CHR_01811	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5CHR_01812	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5CHR_01814	COG0436	Aminotransferase
E5CHR_01817	COG1763	Mo-molybdopterin cofactor biosynthetic process
E5CHR_01818	COG0303	'Molybdopterin
E5CHR_01819	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E5CHR_01820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5CHR_01821	COG0314	molybdopterin synthase activity
E5CHR_01822	COG0583	DNA-binding transcription factor activity
E5CHR_01826	COG0542	response to heat
E5CHR_01834	COG0431	NADPH-dependent FMN reductase
E5CHR_01835	COG1393	Belongs to the ArsC family
E5CHR_01840	COG3214	Protein conserved in bacteria
E5CHR_01842	COG2084	Dehydrogenase
E5CHR_01846	COG0673	inositol 2-dehydrogenase activity
E5CHR_01851	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_01852	COG1309	transcriptional regulator
E5CHR_01853	COG0028	Belongs to the TPP enzyme family
E5CHR_01856	COG2224	Isocitrate lyase
E5CHR_01857	COG2246	polysaccharide biosynthetic process
E5CHR_01858	COG0546	phosphoglycolate phosphatase activity
E5CHR_01858	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5CHR_01860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5CHR_01861	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5CHR_01862	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5CHR_01863	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5CHR_01864	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5CHR_01865	COG0072	phenylalanine-tRNA ligase activity
E5CHR_01865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5CHR_01866	COG0776	regulation of translation
E5CHR_01869	COG0582	viral genome integration into host DNA
E5CHR_01874	COG4983	Phage plasmid primase, P4 family domain protein
E5CHR_01878	COG0025	NhaP-type Na H and K H
E5CHR_01879	COG0667	Aldo Keto reductase
E5CHR_01881	COG0583	DNA-binding transcription factor activity
E5CHR_01885	COG1960	acyl-CoA dehydrogenase activity
E5CHR_01886	COG1024	Enoyl-CoA hydratase
E5CHR_01887	COG0427	acetyl-CoA hydrolase
E5CHR_01890	COG0583	DNA-binding transcription factor activity
E5CHR_01891	COG1968	undecaprenyl-diphosphatase activity
E5CHR_01896	COG1132	(ABC) transporter
E5CHR_01897	COG3045	CreA protein
E5CHR_01903	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5CHR_01904	COG0183	Belongs to the thiolase family
E5CHR_01905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5CHR_01906	COG0477	Major facilitator Superfamily
E5CHR_01907	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_01908	COG1301	dicarboxylic acid transport
E5CHR_01909	COG4651	solute:proton antiporter activity
E5CHR_01909	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5CHR_01912	COG1070	Carbohydrate kinase
E5CHR_01913	COG4753	response regulator
E5CHR_01913	COG2207	Transcriptional regulator
E5CHR_01915	COG0246	Mannitol dehydrogenase
E5CHR_01916	COG3842	ATPase activity
E5CHR_01917	COG0395	ABC-type sugar transport system, permease component
E5CHR_01918	COG1175	transmembrane transport
E5CHR_01928	COG2165	general secretion pathway protein
E5CHR_01940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5CHR_01942	COG0747	negative chemotaxis
E5CHR_01945	COG0747	negative chemotaxis
E5CHR_01946	COG0601	transmembrane transport
E5CHR_01947	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5CHR_01950	COG1473	amidohydrolase
E5CHR_01952	COG0745	RESPONSE REGULATOR receiver
E5CHR_01957	COG2770	Histidine kinase
E5CHR_01957	COG2208	phosphoserine phosphatase activity
E5CHR_01962	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_01966	COG1309	transcriptional regulator
E5CHR_01969	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5CHR_01970	COG1126	abc transporter atp-binding protein
E5CHR_01971	COG0765	amino acid transport
E5CHR_01973	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_01974	COG1802	Transcriptional regulator
E5CHR_01975	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5CHR_01975	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5CHR_01976	COG1703	isobutyryl-CoA mutase activity
E5CHR_01977	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5CHR_01978	COG4770	biotin carboxylase activity
E5CHR_01981	COG2878	Part of a membrane complex involved in electron transport
E5CHR_01984	COG0556	nucleotide-excision repair
E5CHR_01985	COG1959	2 iron, 2 sulfur cluster binding
E5CHR_01986	COG1104	cysteine desulfurase activity
E5CHR_01987	COG0822	iron-sulfur transferase activity
E5CHR_01989	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5CHR_01990	COG0443	Heat shock 70 kDa protein
E5CHR_01992	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5CHR_01997	COG0167	dihydroorotate dehydrogenase activity
E5CHR_01998	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5CHR_02001	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5CHR_02002	COG4566	intracellular signal transduction
E5CHR_02003	COG4191	Histidine kinase
E5CHR_02004	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5CHR_02005	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5CHR_02006	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5CHR_02007	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5CHR_02008	COG0791	NLP P60 protein
E5CHR_02009	COG2133	pyrroloquinoline quinone binding
E5CHR_02011	COG2368	4-hydroxyphenylacetate
E5CHR_02017	COG0567	Dehydrogenase, E1 component
E5CHR_02018	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5CHR_02019	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5CHR_02020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5CHR_02023	COG1199	ATP-dependent helicase activity
E5CHR_02025	COG0564	pseudouridine synthase activity
E5CHR_02026	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5CHR_02027	COG1187	pseudouridine synthase activity
E5CHR_02028	COG0105	UTP biosynthetic process
E5CHR_02029	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5CHR_02032	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5CHR_02033	COG0124	histidyl-tRNA synthetase
E5CHR_02035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5CHR_02036	COG1160	GTP binding
E5CHR_02037	COG1923	regulation of RNA biosynthetic process
E5CHR_02038	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5CHR_02039	COG0330	HflC and HflK could
E5CHR_02040	COG0330	HflC and HflK could
E5CHR_02042	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5CHR_02043	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5CHR_02045	COG0626	cystathionine gamma-synthase activity
E5CHR_02048	COG1136	(ABC) transporter
E5CHR_02049	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5CHR_02051	COG3618	amidohydrolase
E5CHR_02052	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02058	COG0667	Aldo Keto reductase
E5CHR_02061	COG1295	ribonuclease BN
E5CHR_02062	COG3119	arylsulfatase activity
E5CHR_02064	COG0583	DNA-binding transcription factor activity
E5CHR_02067	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5CHR_02071	COG2951	lytic endotransglycosylase activity
E5CHR_02074	COG0714	Associated with various cellular activities
E5CHR_02076	COG1196	nuclear chromosome segregation
E5CHR_02076	COG3264	Mechanosensitive ion channel
E5CHR_02079	COG1960	acyl-CoA dehydrogenase activity
E5CHR_02085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5CHR_02089	COG1414	Transcriptional regulator
E5CHR_02090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5CHR_02092	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5CHR_02094	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5CHR_02095	COG2814	Major facilitator Superfamily
E5CHR_02100	COG0583	DNA-binding transcription factor activity
E5CHR_02101	COG0477	Major facilitator Superfamily
E5CHR_02104	COG1116	anion transmembrane transporter activity
E5CHR_02108	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E5CHR_02114	COG3384	dioxygenase
E5CHR_02118	COG3384	dioxygenase
E5CHR_02121	COG4941	Belongs to the sigma-70 factor family
E5CHR_02122	COG3795	YCII-related domain
E5CHR_02126	COG3842	ATPase activity
E5CHR_02131	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5CHR_02131	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5CHR_02132	COG0509	glycine decarboxylation via glycine cleavage system
E5CHR_02133	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5CHR_02136	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02139	COG0642	Histidine kinase
E5CHR_02140	COG0745	RESPONSE REGULATOR receiver
E5CHR_02142	COG2194	sulfuric ester hydrolase activity
E5CHR_02147	COG4302	ethanolamine ammonia-lyase activity
E5CHR_02148	COG4303	Ethanolamine ammonia lyase large subunit
E5CHR_02149	COG0545	Peptidyl-prolyl cis-trans isomerase
E5CHR_02152	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E5CHR_02153	COG2169	Transcriptional regulator
E5CHR_02153	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5CHR_02160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_02166	COG1024	Enoyl-CoA hydratase
E5CHR_02168	COG0583	DNA-binding transcription factor activity
E5CHR_02169	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5CHR_02171	COG3800	Transcriptional regulator
E5CHR_02171	COG1396	sequence-specific DNA binding
E5CHR_02174	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_02179	COG2366	antibiotic biosynthetic process
E5CHR_02180	COG1183	phosphatidylcholine synthase activity
E5CHR_02181	COG0519	Catalyzes the synthesis of GMP from XMP
E5CHR_02182	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5CHR_02186	COG1132	(ABC) transporter
E5CHR_02187	COG3384	dioxygenase
E5CHR_02196	COG0587	DNA-directed DNA polymerase activity
E5CHR_02198	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E5CHR_02199	COG4608	Belongs to the ABC transporter superfamily
E5CHR_02200	COG0444	Belongs to the ABC transporter superfamily
E5CHR_02201	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5CHR_02202	COG0601	transmembrane transport
E5CHR_02203	COG0747	negative chemotaxis
E5CHR_02209	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5CHR_02210	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02214	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5CHR_02220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5CHR_02223	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5CHR_02229	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5CHR_02230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5CHR_02231	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5CHR_02231	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5CHR_02233	COG1741	Belongs to the pirin family
E5CHR_02234	COG2259	Doxx family
E5CHR_02236	COG1741	Belongs to the pirin family
E5CHR_02240	COG0848	biopolymer transport protein
E5CHR_02242	COG0824	Thioesterase
E5CHR_02243	COG0436	Aminotransferase
E5CHR_02244	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5CHR_02245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5CHR_02248	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5CHR_02248	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5CHR_02255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5CHR_02256	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5CHR_02257	COG0741	lytic transglycosylase activity
E5CHR_02260	COG3228	Belongs to the MtfA family
E5CHR_02261	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5CHR_02265	COG0215	cysteine-tRNA ligase activity
E5CHR_02267	COG0825	malonyl-CoA metabolic process
E5CHR_02268	COG0037	tRNA processing
E5CHR_02271	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5CHR_02271	COG2755	lipolytic protein G-D-S-L family
E5CHR_02272	COG1609	Transcriptional regulator
E5CHR_02273	COG1063	alcohol dehydrogenase
E5CHR_02274	COG1070	Carbohydrate kinase
E5CHR_02277	COG1116	anion transmembrane transporter activity
E5CHR_02277	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5CHR_02278	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_02283	COG1525	nuclease
E5CHR_02285	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5CHR_02285	COG1024	Enoyl-CoA hydratase
E5CHR_02286	COG0596	Alpha beta hydrolase
E5CHR_02287	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02287	COG3321	synthase
E5CHR_02287	COG0604	alcohol dehydrogenase
E5CHR_02293	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5CHR_02294	COG4638	Rieske (2fe-2S)
E5CHR_02295	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5CHR_02299	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E5CHR_02307	COG0411	ABC transporter
E5CHR_02309	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_02310	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02315	COG2326	polyphosphate kinase activity
E5CHR_02317	COG0642	Histidine kinase
E5CHR_02319	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_02324	COG2204	response regulator
E5CHR_02327	COG1126	abc transporter atp-binding protein
E5CHR_02332	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5CHR_02333	COG1011	Hydrolase
E5CHR_02335	COG2124	cytochrome p450
E5CHR_02339	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02347	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02348	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02352	COG2124	cytochrome p450
E5CHR_02354	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5CHR_02358	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_02363	COG0655	NAD(P)H dehydrogenase (quinone) activity
E5CHR_02366	COG0477	Major facilitator Superfamily
E5CHR_02367	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02369	COG2814	Major facilitator Superfamily
E5CHR_02371	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_02377	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E5CHR_02381	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5CHR_02384	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5CHR_02385	COG0740	serine-type endopeptidase activity
E5CHR_02386	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5CHR_02387	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5CHR_02394	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5CHR_02397	COG0114	fumarate hydratase activity
E5CHR_02399	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5CHR_02401	COG4654	Cytochrome c, class I
E5CHR_02403	COG0129	dihydroxy-acid dehydratase activity
E5CHR_02404	COG0583	DNA-binding transcription factor activity
E5CHR_02405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5CHR_02407	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_02413	COG4206	TonB-dependent receptor
E5CHR_02414	COG1797	cobyrinic acid a,c-diamide synthase activity
E5CHR_02416	COG4607	ABC-type enterochelin transport system periplasmic component
E5CHR_02417	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5CHR_02418	COG1121	(ABC) transporter
E5CHR_02419	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E5CHR_02420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5CHR_02426	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5CHR_02428	COG1538	Outer membrane efflux protein
E5CHR_02429	COG2188	Transcriptional regulator
E5CHR_02431	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_02433	COG3119	arylsulfatase activity
E5CHR_02436	COG1492	cobalamin metabolic process
E5CHR_02437	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5CHR_02438	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5CHR_02440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5CHR_02441	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5CHR_02443	COG0626	cystathionine gamma-synthase activity
E5CHR_02444	COG0560	Phosphoserine phosphatase
E5CHR_02445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5CHR_02446	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5CHR_02446	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5CHR_02447	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5CHR_02447	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5CHR_02448	COG2205	protein histidine kinase activity
E5CHR_02449	COG0745	RESPONSE REGULATOR receiver
E5CHR_02452	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5CHR_02456	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E5CHR_02457	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5CHR_02459	COG0557	exoribonuclease II activity
E5CHR_02460	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02464	COG0052	Belongs to the universal ribosomal protein uS2 family
E5CHR_02465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5CHR_02466	COG0528	UMP kinase activity
E5CHR_02467	COG0233	cytoplasmic translational termination
E5CHR_02469	COG0575	Belongs to the CDS family
E5CHR_02470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5CHR_02471	COG0750	zinc metalloprotease
E5CHR_02474	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5CHR_02475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5CHR_02476	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5CHR_02477	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5CHR_02478	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5CHR_02479	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5CHR_02480	COG0505	Belongs to the CarA family
E5CHR_02481	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5CHR_02483	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5CHR_02486	COG1534	Rna-binding protein
E5CHR_02487	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5CHR_02488	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5CHR_02490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5CHR_02495	COG1024	Enoyl-CoA hydratase
E5CHR_02496	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5CHR_02498	COG2814	Major facilitator Superfamily
E5CHR_02499	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5CHR_02500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5CHR_02501	COG0252	asparaginase activity
E5CHR_02502	COG0563	adenylate kinase activity
E5CHR_02503	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E5CHR_02504	COG2835	tetraacyldisaccharide 4'-kinase activity
E5CHR_02505	COG1663	tetraacyldisaccharide 4'-kinase activity
E5CHR_02506	COG0848	biopolymer transport protein
E5CHR_02507	COG0811	peptide transport
E5CHR_02508	COG1570	exodeoxyribonuclease VII activity
E5CHR_02509	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5CHR_02513	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5CHR_02514	COG0542	response to heat
E5CHR_02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_02516	COG2925	Exonuclease
E5CHR_02519	COG0456	acetyltransferase
E5CHR_02522	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5CHR_02524	COG5002	protein histidine kinase activity
E5CHR_02527	COG3038	cytochrome b561
E5CHR_02531	COG0402	S-adenosylhomocysteine deaminase activity
E5CHR_02532	COG0583	DNA-binding transcription factor activity
E5CHR_02534	COG1024	Enoyl-CoA hydratase
E5CHR_02537	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_02540	COG5001	Diguanylate cyclase
E5CHR_02540	COG3300	MHYT domain
E5CHR_02541	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5CHR_02544	COG0433	COG0433 Predicted ATPase
E5CHR_02547	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5CHR_02554	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02559	COG0217	transcriptional regulatory protein
E5CHR_02560	COG0151	Belongs to the GarS family
E5CHR_02561	COG0408	coproporphyrinogen oxidase activity
E5CHR_02562	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5CHR_02563	COG0799	negative regulation of ribosome biogenesis
E5CHR_02564	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5CHR_02565	COG0424	maF-like protein
E5CHR_02566	COG1530	ribonuclease E activity
E5CHR_02567	COG1132	(ABC) transporter
E5CHR_02568	COG0823	Involved in the tonB-independent uptake of proteins
E5CHR_02569	COG2885	chlorophyll binding
E5CHR_02571	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5CHR_02574	COG0583	DNA-binding transcription factor activity
E5CHR_02579	COG2890	protein-(glutamine-N5) methyltransferase activity
E5CHR_02580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5CHR_02582	COG2171	N-acyltransferase activity
E5CHR_02583	COG0436	Aminotransferase
E5CHR_02584	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5CHR_02584	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5CHR_02585	COG1643	Atp-dependent helicase
E5CHR_02588	COG0436	Aminotransferase
E5CHR_02589	COG0583	DNA-binding transcription factor activity
E5CHR_02592	COG0795	lipopolysaccharide-transporting ATPase activity
E5CHR_02593	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5CHR_02600	COG0612	Peptidase, M16
E5CHR_02601	COG0582	viral genome integration into host DNA
E5CHR_02629	COG1982	Orn Lys Arg decarboxylase major
E5CHR_02630	COG1793	dna ligase
E5CHR_02631	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5CHR_02632	COG4166	transmembrane transport
E5CHR_02633	COG4174	ABC transporter (Permease)
E5CHR_02634	COG4239	(ABC) transporter, permease
E5CHR_02635	COG4172	Belongs to the ABC transporter superfamily
E5CHR_02636	COG0477	Major facilitator Superfamily
E5CHR_02637	COG0779	Required for maturation of 30S ribosomal subunits
E5CHR_02638	COG0195	Participates in both transcription termination and antitermination
E5CHR_02638	COG2251	uridine kinase activity
E5CHR_02639	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5CHR_02640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5CHR_02641	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5CHR_02649	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5CHR_02650	COG2867	negative regulation of translational initiation
E5CHR_02654	COG0519	Catalyzes the synthesis of GMP from XMP
E5CHR_02654	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5CHR_02655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5CHR_02656	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E5CHR_02665	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5CHR_02669	COG3158	transport of potassium into the cell
E5CHR_02671	COG0084	hydrolase, TatD family'
E5CHR_02674	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5CHR_02675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5CHR_02683	COG2183	response to ionizing radiation
E5CHR_02686	COG0534	Mate efflux family protein
E5CHR_02701	COG0477	Major facilitator Superfamily
E5CHR_02702	COG2814	Major facilitator Superfamily
E5CHR_02703	COG2814	Major facilitator Superfamily
E5CHR_02710	COG1960	acyl-CoA dehydrogenase activity
E5CHR_02711	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E5CHR_02712	COG4638	Rieske (2fe-2S)
E5CHR_02715	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02718	COG3008	intermembrane lipid transfer
E5CHR_02718	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5CHR_02719	COG2995	paraquat-inducible protein a
E5CHR_02720	COG2995	paraquat-inducible protein a
E5CHR_02722	COG5507	3-demethylubiquinone-9 3-methyltransferase
E5CHR_02725	COG1960	acyl-CoA dehydrogenase activity
E5CHR_02726	COG2130	NADP-dependent
E5CHR_02730	COG1960	acyl-CoA dehydrogenase activity
E5CHR_02733	COG0183	Belongs to the thiolase family
E5CHR_02734	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5CHR_02735	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5CHR_02735	COG1024	Enoyl-CoA hydratase
E5CHR_02736	COG1129	ABC transporter
E5CHR_02737	COG0411	ABC transporter
E5CHR_02742	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_02743	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5CHR_02744	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5CHR_02745	COG2917	probably involved in intracellular septation
E5CHR_02747	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5CHR_02748	COG0047	phosphoribosylformylglycinamidine synthase activity
E5CHR_02748	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5CHR_02749	COG0024	Methionine aminopeptidase
E5CHR_02750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5CHR_02751	COG0765	amino acid transport
E5CHR_02752	COG4597	amino acid ABC transporter
E5CHR_02753	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5CHR_02754	COG2259	Doxx family
E5CHR_02755	COG0242	peptide deformylase activity
E5CHR_02757	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5CHR_02759	COG1196	nuclear chromosome segregation
E5CHR_02762	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5CHR_02763	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5CHR_02764	COG4208	sulfate ABC transporter
E5CHR_02766	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5CHR_02768	COG0450	alkyl hydroperoxide reductase
E5CHR_02770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5CHR_02771	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5CHR_02774	COG1045	serine acetyltransferase
E5CHR_02776	COG1116	anion transmembrane transporter activity
E5CHR_02777	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_02778	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5CHR_02779	COG0431	NADPH-dependent FMN reductase
E5CHR_02780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5CHR_02781	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E5CHR_02782	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5CHR_02782	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5CHR_02784	COG1272	protein, Hemolysin III
E5CHR_02786	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5CHR_02787	COG3383	formate dehydrogenase (NAD+) activity
E5CHR_02795	COG0175	sulfate reduction
E5CHR_02796	COG0175	sulfate reduction
E5CHR_02797	COG2895	sulfate adenylyltransferase (ATP) activity
E5CHR_02798	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5CHR_02799	COG0492	ferredoxin-NADP+ reductase activity
E5CHR_02800	COG0671	phosphoesterase, PA-phosphatase related
E5CHR_02803	COG0351	phosphomethylpyrimidine kinase
E5CHR_02806	COG2022	thiamine diphosphate biosynthetic process
E5CHR_02808	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5CHR_02808	COG2755	lipolytic protein G-D-S-L family
E5CHR_02814	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5CHR_02819	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_02821	COG2175	clavaminate synthase activity
E5CHR_02825	COG1024	Enoyl-CoA hydratase
E5CHR_02826	COG1960	acyl-CoA dehydrogenase activity
E5CHR_02827	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_02829	COG1024	Enoyl-CoA hydratase
E5CHR_02834	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_02835	COG0642	Histidine kinase
E5CHR_02836	COG0745	RESPONSE REGULATOR receiver
E5CHR_02837	COG1414	Transcriptional regulator
E5CHR_02838	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5CHR_02840	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5CHR_02841	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E5CHR_02842	COG1414	Transcriptional regulator
E5CHR_02844	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5CHR_02845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5CHR_02846	COG1183	phosphatidylcholine synthase activity
E5CHR_02847	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5CHR_02848	COG0440	acetolactate synthase activity
E5CHR_02849	COG0028	Belongs to the TPP enzyme family
E5CHR_02854	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5CHR_02856	COG0347	Belongs to the P(II) protein family
E5CHR_02860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5CHR_02866	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_02868	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_02875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5CHR_02876	COG0746	molybdenum cofactor guanylyltransferase activity
E5CHR_02878	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5CHR_02878	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5CHR_02879	COG0328	RNA-DNA hybrid ribonuclease activity
E5CHR_02881	COG1388	LysM domain
E5CHR_02881	COG0741	lytic transglycosylase activity
E5CHR_02882	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_02884	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5CHR_02886	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5CHR_02887	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5CHR_02888	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5CHR_02931	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5CHR_02931	COG0493	'glutamate synthase
E5CHR_02932	COG1074	ATP-dependent DNA helicase activity
E5CHR_02935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5CHR_02936	COG0673	inositol 2-dehydrogenase activity
E5CHR_02937	COG0254	rRNA binding
E5CHR_02939	COG0534	Mate efflux family protein
E5CHR_02940	COG5002	protein histidine kinase activity
E5CHR_02943	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5CHR_02944	COG0581	inorganic phosphate transmembrane transporter activity
E5CHR_02945	COG0573	inorganic phosphate transmembrane transporter activity
E5CHR_02946	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5CHR_02947	COG0248	Ppx GppA phosphatase
E5CHR_02951	COG3634	alkyl hydroperoxide reductase activity
E5CHR_02952	COG0625	glutathione transferase activity
E5CHR_02956	COG0583	DNA-binding transcription factor activity
E5CHR_02959	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5CHR_02960	COG0765	amino acid transport
E5CHR_02961	COG0765	amino acid transport
E5CHR_02964	COG1082	Xylose isomerase domain protein TIM barrel
E5CHR_02965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5CHR_02966	COG0698	ribose 5-phosphate isomerase
E5CHR_02970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_02971	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5CHR_02975	COG1522	sequence-specific DNA binding
E5CHR_02978	COG4993	Dehydrogenase
E5CHR_02979	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
E5CHR_02983	COG2188	Transcriptional regulator
E5CHR_02985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_02988	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_02990	COG0183	Belongs to the thiolase family
E5CHR_02992	COG0439	Biotin carboxylase
E5CHR_02997	COG0156	8-amino-7-oxononanoate synthase activity
E5CHR_02999	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5CHR_03000	COG2124	cytochrome p450
E5CHR_03001	COG1309	transcriptional regulator
E5CHR_03002	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5CHR_03004	COG0410	ABC transporter
E5CHR_03005	COG0411	ABC transporter
E5CHR_03007	COG1335	isochorismatase
E5CHR_03013	COG0583	DNA-binding transcription factor activity
E5CHR_03014	COG0277	FAD linked oxidase domain protein
E5CHR_03015	COG0277	FAD linked oxidase domain protein
E5CHR_03016	COG0247	lactate metabolic process
E5CHR_03018	COG3119	arylsulfatase activity
E5CHR_03025	COG2149	membrane
E5CHR_03028	COG0726	polysaccharide deacetylase
E5CHR_03033	COG2076	Multidrug Resistance protein
E5CHR_03034	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5CHR_03036	COG0667	Aldo Keto reductase
E5CHR_03039	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03042	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03049	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5CHR_03050	COG0366	Alpha amylase catalytic
E5CHR_03054	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5CHR_03055	COG1640	4-alpha-glucanotransferase
E5CHR_03057	COG1414	Transcriptional regulator
E5CHR_03059	COG0243	molybdopterin cofactor binding
E5CHR_03061	COG1024	Enoyl-CoA hydratase
E5CHR_03062	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_03063	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03064	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_03067	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_03069	COG1024	Enoyl-CoA hydratase
E5CHR_03079	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5CHR_03080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_03081	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03083	COG1024	Enoyl-CoA hydratase
E5CHR_03087	COG0473	3-isopropylmalate dehydrogenase activity
E5CHR_03087	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5CHR_03095	COG1129	ABC transporter
E5CHR_03097	COG1053	succinate dehydrogenase
E5CHR_03098	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_03101	COG4221	oxidoreductase activity
E5CHR_03108	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03109	COG4689	acetoacetate decarboxylase
E5CHR_03116	COG2188	Transcriptional regulator
E5CHR_03119	COG0765	amino acid transport
E5CHR_03120	COG0765	amino acid transport
E5CHR_03122	COG1126	abc transporter atp-binding protein
E5CHR_03123	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03124	COG0006	proline dipeptidase activity
E5CHR_03128	COG2308	Evidence 4 Homologs of previously reported genes of
E5CHR_03132	COG1305	Transglutaminase-like
E5CHR_03134	COG1522	sequence-specific DNA binding
E5CHR_03136	COG1280	lysine exporter protein (LysE YggA)
E5CHR_03137	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5CHR_03141	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_03143	COG1024	Enoyl-CoA hydratase
E5CHR_03144	COG1609	Transcriptional regulator
E5CHR_03146	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5CHR_03148	COG1126	abc transporter atp-binding protein
E5CHR_03151	COG0765	amino acid transport
E5CHR_03159	COG0739	heme binding
E5CHR_03159	COG1196	nuclear chromosome segregation
E5CHR_03159	COG0741	lytic transglycosylase activity
E5CHR_03168	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5CHR_03169	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E5CHR_03170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5CHR_03173	COG2850	peptidyl-arginine hydroxylation
E5CHR_03174	COG1047	Peptidyl-prolyl cis-trans
E5CHR_03177	COG0583	DNA-binding transcription factor activity
E5CHR_03178	COG0756	dUTP diphosphatase activity
E5CHR_03180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5CHR_03181	COG0504	CTP synthase activity
E5CHR_03182	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E5CHR_03184	COG0148	phosphopyruvate hydratase activity
E5CHR_03185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E5CHR_03188	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5CHR_03190	COG2833	Protein of unknown function (DUF455)
E5CHR_03193	COG4974	Belongs to the 'phage' integrase family
E5CHR_03194	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03197	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5CHR_03198	COG0802	atpase or kinase
E5CHR_03199	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5CHR_03202	COG0586	Pfam SNARE associated Golgi protein
E5CHR_03203	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5CHR_03207	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5CHR_03208	COG4181	ATPase activity
E5CHR_03209	COG0583	DNA-binding transcription factor activity
E5CHR_03216	COG0583	DNA-binding transcription factor activity
E5CHR_03220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5CHR_03222	COG3795	YCII-related domain
E5CHR_03223	COG4941	Belongs to the sigma-70 factor family
E5CHR_03232	COG2814	Major facilitator Superfamily
E5CHR_03233	COG1566	PFAM secretion protein HlyD family protein
E5CHR_03234	COG1538	Outer membrane efflux protein
E5CHR_03235	COG1846	Transcriptional regulator
E5CHR_03236	COG1132	(ABC) transporter
E5CHR_03238	COG0494	nUDIX hydrolase
E5CHR_03240	COG1007	ATP synthesis coupled electron transport
E5CHR_03243	COG0713	ATP synthesis coupled electron transport
E5CHR_03245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5CHR_03246	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5CHR_03247	COG1034	ATP synthesis coupled electron transport
E5CHR_03250	COG0649	NAD binding
E5CHR_03251	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5CHR_03252	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5CHR_03253	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5CHR_03256	COG0149	triose-phosphate isomerase activity
E5CHR_03257	COG3321	synthase
E5CHR_03257	COG0604	alcohol dehydrogenase
E5CHR_03257	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5CHR_03257	COG4221	oxidoreductase activity
E5CHR_03258	COG1185	polyribonucleotide nucleotidyltransferase activity
E5CHR_03259	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5CHR_03260	COG0436	Aminotransferase
E5CHR_03261	COG0683	leucine binding
E5CHR_03264	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5CHR_03265	COG3707	response regulator
E5CHR_03266	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5CHR_03267	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_03268	COG1116	anion transmembrane transporter activity
E5CHR_03270	COG2223	nitrite transmembrane transporter activity
E5CHR_03271	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5CHR_03273	COG0243	molybdopterin cofactor binding
E5CHR_03274	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5CHR_03277	COG2081	HI0933 family
E5CHR_03278	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5CHR_03279	COG1610	YqeY-like protein
E5CHR_03281	COG0312	modulator of DNA gyrase
E5CHR_03282	COG3028	Belongs to the UPF0307 family
E5CHR_03283	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5CHR_03284	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5CHR_03286	COG0765	amino acid transport
E5CHR_03287	COG0765	amino acid transport
E5CHR_03288	COG4221	oxidoreductase activity
E5CHR_03289	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5CHR_03291	COG1984	allophanate hydrolase subunit 2
E5CHR_03292	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E5CHR_03294	COG0511	ligase activity, forming carbon-carbon bonds
E5CHR_03296	COG0436	Aminotransferase
E5CHR_03297	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5CHR_03309	COG0436	Aminotransferase
E5CHR_03311	COG3265	gluconokinase activity
E5CHR_03312	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03313	COG1063	alcohol dehydrogenase
E5CHR_03314	COG1045	serine acetyltransferase
E5CHR_03317	COG1289	transmembrane transporter activity
E5CHR_03321	COG2375	cellular response to nickel ion
E5CHR_03326	COG2159	amidohydrolase
E5CHR_03330	COG0583	DNA-binding transcription factor activity
E5CHR_03331	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5CHR_03334	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_03336	COG0583	DNA-binding transcription factor activity
E5CHR_03337	COG3119	arylsulfatase activity
E5CHR_03338	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03339	COG1968	undecaprenyl-diphosphatase activity
E5CHR_03341	COG3246	L-lysine catabolic process to acetate
E5CHR_03343	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_03344	COG2301	Belongs to the HpcH HpaI aldolase family
E5CHR_03348	COG1802	Transcriptional regulator
E5CHR_03350	COG1024	Enoyl-CoA hydratase
E5CHR_03353	COG1360	Flagellar Motor Protein
E5CHR_03359	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5CHR_03360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5CHR_03365	COG2972	Histidine kinase
E5CHR_03368	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5CHR_03373	COG0411	ABC transporter
E5CHR_03378	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5CHR_03381	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03383	COG2918	glutathione biosynthetic process
E5CHR_03384	COG0400	carboxylic ester hydrolase activity
E5CHR_03386	COG0583	DNA-binding transcription factor activity
E5CHR_03399	COG2354	Protein conserved in bacteria
E5CHR_03402	COG4628	conserved protein (DUF2132)
E5CHR_03405	COG0564	pseudouridine synthase activity
E5CHR_03406	COG0589	response to stress
E5CHR_03409	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E5CHR_03410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5CHR_03411	COG1252	NADH dehydrogenase
E5CHR_03413	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_03414	COG1764	response to oxidative stress
E5CHR_03417	COG0789	Transcriptional regulator
E5CHR_03419	COG3191	aminopeptidase activity
E5CHR_03425	COG0488	(ABC) transporter
E5CHR_03426	COG0513	Belongs to the DEAD box helicase family
E5CHR_03427	COG3842	ATPase activity
E5CHR_03429	COG1175	transmembrane transport
E5CHR_03431	COG2186	Transcriptional regulator
E5CHR_03432	COG3734	2-keto-3-deoxy-galactonokinase
E5CHR_03433	COG0800	Aldolase
E5CHR_03435	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E5CHR_03438	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5CHR_03439	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5CHR_03451	COG1595	DNA-templated transcription, initiation
E5CHR_03453	COG3474	cytochrome
E5CHR_03454	COG0302	gtp cyclohydrolase
E5CHR_03455	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03460	COG0346	lactoylglutathione lyase activity
E5CHR_03463	COG0800	Aldolase
E5CHR_03469	COG0259	pyridoxamine-phosphate oxidase activity
E5CHR_03472	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5CHR_03473	COG2301	Belongs to the HpcH HpaI aldolase family
E5CHR_03479	COG4772	TonB-dependent receptor
E5CHR_03481	COG2986	histidine ammonia-lyase
E5CHR_03482	COG1309	transcriptional regulator
E5CHR_03483	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5CHR_03486	COG2207	Transcriptional regulator
E5CHR_03487	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_03489	COG2030	dehydratase
E5CHR_03494	COG1803	Methylglyoxal synthase
E5CHR_03495	COG0235	Class ii aldolase
E5CHR_03504	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5CHR_03505	COG2863	cytochrome
E5CHR_03506	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5CHR_03506	COG2010	Cytochrome c
E5CHR_03509	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5CHR_03510	COG1309	transcriptional regulator
E5CHR_03513	COG1132	(ABC) transporter
E5CHR_03516	COG2217	Heavy metal translocating P-type atpase
E5CHR_03517	COG0789	Transcriptional regulator
E5CHR_03523	COG0745	RESPONSE REGULATOR receiver
E5CHR_03527	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5CHR_03528	COG2301	Belongs to the HpcH HpaI aldolase family
E5CHR_03532	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5CHR_03535	COG1286	toxin biosynthetic process
E5CHR_03537	COG0285	dihydrofolate synthase activity
E5CHR_03538	COG1393	Belongs to the ArsC family
E5CHR_03540	COG3123	guanosine phosphorylase activity
E5CHR_03541	COG0137	argininosuccinate synthase activity
E5CHR_03542	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5CHR_03543	COG1666	GTP binding
E5CHR_03545	COG0251	oxidation-reduction process
E5CHR_03546	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5CHR_03547	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5CHR_03548	COG0667	Aldo Keto reductase
E5CHR_03550	COG3850	Histidine kinase
E5CHR_03550	COG4999	Histidine kinase
E5CHR_03550	COG3437	response regulator, receiver
E5CHR_03550	COG2205	protein histidine kinase activity
E5CHR_03551	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5CHR_03553	COG5002	protein histidine kinase activity
E5CHR_03553	COG5000	phosphorelay sensor kinase activity
E5CHR_03554	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E5CHR_03555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5CHR_03556	COG0308	aminopeptidase N
E5CHR_03557	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5CHR_03561	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03562	COG0583	DNA-binding transcription factor activity
E5CHR_03563	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5CHR_03564	COG1301	dicarboxylic acid transport
E5CHR_03567	COG0745	RESPONSE REGULATOR receiver
E5CHR_03568	COG2205	protein histidine kinase activity
E5CHR_03571	COG0840	transmembrane signaling receptor activity
E5CHR_03572	COG0745	RESPONSE REGULATOR receiver
E5CHR_03575	COG0840	transmembrane signaling receptor activity
E5CHR_03576	COG0835	chemotaxis
E5CHR_03582	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5CHR_03583	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5CHR_03584	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E5CHR_03585	COG0745	RESPONSE REGULATOR receiver
E5CHR_03587	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E5CHR_03588	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5CHR_03590	COG2198	Histidine kinase
E5CHR_03590	COG0643	Histidine kinase
E5CHR_03599	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E5CHR_03601	COG1677	Flagellar hook-basal body complex protein FliE
E5CHR_03602	COG1766	The M ring may be actively involved in energy transduction
E5CHR_03603	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5CHR_03607	COG3144	bacterial-type flagellum assembly
E5CHR_03608	COG1580	Controls the rotational direction of flagella during chemotaxis
E5CHR_03609	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5CHR_03612	COG1338	Plays a role in the flagellum-specific transport system
E5CHR_03613	COG1987	bacterial-type flagellum assembly
E5CHR_03617	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5CHR_03623	COG1256	bacterial-type flagellum assembly
E5CHR_03624	COG0840	transmembrane signaling receptor activity
E5CHR_03626	COG0835	chemotaxis
E5CHR_03627	COG0840	transmembrane signaling receptor activity
E5CHR_03628	COG0835	chemotaxis
E5CHR_03629	COG3951	Flagellar rod assembly protein muramidase FlgJ
E5CHR_03629	COG1705	Flagellar rod assembly protein muramidase FlgJ
E5CHR_03630	COG1706	bacterial-type flagellum-dependent cell motility
E5CHR_03631	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5CHR_03632	COG4786	Flagellar basal body rod
E5CHR_03635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E5CHR_03636	COG1558	bacterial-type flagellum-dependent cell motility
E5CHR_03637	COG1815	bacterial-type flagellum-dependent cell motility
E5CHR_03642	COG0604	alcohol dehydrogenase
E5CHR_03643	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5CHR_03648	COG0583	DNA-binding transcription factor activity
E5CHR_03649	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03653	COG3302	dmso reductase anchor subunit
E5CHR_03654	COG0437	4 iron, 4 sulfur cluster binding
E5CHR_03655	COG0243	molybdopterin cofactor binding
E5CHR_03656	COG0583	DNA-binding transcription factor activity
E5CHR_03661	COG1414	Transcriptional regulator
E5CHR_03666	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_03667	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_03671	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03672	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5CHR_03673	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03675	COG1414	Transcriptional regulator
E5CHR_03676	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E5CHR_03677	COG0477	Major facilitator Superfamily
E5CHR_03678	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_03679	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5CHR_03680	COG4521	taurine ABC transporter
E5CHR_03681	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5CHR_03685	COG0601	transmembrane transport
E5CHR_03686	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5CHR_03687	COG0444	Belongs to the ABC transporter superfamily
E5CHR_03688	COG4608	Belongs to the ABC transporter superfamily
E5CHR_03692	COG0247	lactate metabolic process
E5CHR_03693	COG1592	Rubrerythrin
E5CHR_03695	COG2197	response regulator
E5CHR_03696	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_03697	COG1253	flavin adenine dinucleotide binding
E5CHR_03698	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5CHR_03699	COG0513	Belongs to the DEAD box helicase family
E5CHR_03700	COG2321	neutral zinc metallopeptidase
E5CHR_03702	COG0717	Belongs to the dCTP deaminase family
E5CHR_03703	COG0402	S-adenosylhomocysteine deaminase activity
E5CHR_03707	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5CHR_03712	COG2252	PERMEase
E5CHR_03714	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5CHR_03719	COG1850	ribulose-bisphosphate carboxylase activity
E5CHR_03721	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5CHR_03722	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5CHR_03723	COG1609	Transcriptional regulator
E5CHR_03726	COG1024	Enoyl-CoA hydratase
E5CHR_03727	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_03728	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_03729	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5CHR_03732	COG0667	Aldo Keto reductase
E5CHR_03739	COG0438	transferase activity, transferring glycosyl groups
E5CHR_03745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5CHR_03745	COG3608	succinylglutamate desuccinylase aspartoacylase
E5CHR_03754	COG0667	Aldo Keto reductase
E5CHR_03760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_03761	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5CHR_03768	COG2084	Dehydrogenase
E5CHR_03769	COG0745	RESPONSE REGULATOR receiver
E5CHR_03770	COG0642	Histidine kinase
E5CHR_03773	COG0671	phosphoesterase, PA-phosphatase related
E5CHR_03774	COG0463	Glycosyl transferase, family 2
E5CHR_03775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5CHR_03777	COG1116	anion transmembrane transporter activity
E5CHR_03778	COG0390	transport system, permease component
E5CHR_03780	COG1609	Transcriptional regulator
E5CHR_03784	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5CHR_03786	COG1950	PFAM Membrane protein of
E5CHR_03787	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_03788	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5CHR_03789	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5CHR_03792	COG1122	ATPase activity
E5CHR_03796	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5CHR_03798	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5CHR_03799	COG2151	metal-sulfur cluster biosynthetic enzyme
E5CHR_03800	COG3396	Phenylacetate-CoA oxygenase
E5CHR_03801	COG3460	Phenylacetate-CoA oxygenase
E5CHR_03802	COG3396	Phenylacetate-CoA oxygenase
E5CHR_03804	COG2050	protein possibly involved in aromatic compounds catabolism
E5CHR_03805	COG1024	Enoyl-CoA hydratase
E5CHR_03807	COG1309	transcriptional regulator
E5CHR_03809	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5CHR_03816	COG3547	Transposase (IS116 IS110 IS902 family)
E5CHR_03817	COG2188	Transcriptional regulator
E5CHR_03818	COG2070	2-Nitropropane dioxygenase
E5CHR_03820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_03821	COG1116	anion transmembrane transporter activity
E5CHR_03824	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E5CHR_03826	COG0392	lysyltransferase activity
E5CHR_03827	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5CHR_03828	COG0142	geranyltranstransferase activity
E5CHR_03829	COG1722	exodeoxyribonuclease VII activity
E5CHR_03838	COG3360	Dodecin
E5CHR_03847	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5CHR_03849	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_03850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5CHR_03854	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5CHR_03855	COG3842	ATPase activity
E5CHR_03856	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5CHR_03858	COG0210	DNA helicase
E5CHR_03859	COG0516	GMP reductase activity
E5CHR_03862	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03864	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5CHR_03865	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_03868	COG2010	Cytochrome c
E5CHR_03868	COG4993	Dehydrogenase
E5CHR_03870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5CHR_03873	COG0535	radical SAM domain protein
E5CHR_03874	COG1129	ABC transporter
E5CHR_03874	COG0842	Transport permease protein
E5CHR_03879	COG0348	domain, Protein
E5CHR_03879	COG3901	Regulator of nitric oxide reductase transcription
E5CHR_03883	COG3851	Histidine kinase
E5CHR_03891	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5CHR_03892	COG0028	Belongs to the TPP enzyme family
E5CHR_03898	COG0513	Belongs to the DEAD box helicase family
E5CHR_03899	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5CHR_03900	COG0501	Belongs to the peptidase M48B family
E5CHR_03901	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5CHR_03902	COG1162	GTPase activity
E5CHR_03903	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5CHR_03904	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5CHR_03906	COG0335	large ribosomal subunit rRNA binding
E5CHR_03907	COG0336	Belongs to the RNA methyltransferase TrmD family
E5CHR_03908	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5CHR_03909	COG0228	four-way junction DNA binding
E5CHR_03912	COG0306	phosphate transporter
E5CHR_03913	COG1392	Phosphate transport regulator
E5CHR_03915	COG0617	tRNA 3'-terminal CCA addition
E5CHR_03916	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5CHR_03917	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5CHR_03920	COG1917	Cupin 2, conserved barrel domain protein
E5CHR_03920	COG4977	sequence-specific DNA binding
E5CHR_03921	COG1289	transmembrane transporter activity
E5CHR_03924	COG0728	peptidoglycan biosynthetic process
E5CHR_03925	COG0268	Binds directly to 16S ribosomal RNA
E5CHR_03927	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5CHR_03928	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5CHR_03929	COG3550	peptidyl-serine autophosphorylation
E5CHR_03930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E5CHR_03932	COG3483	tryptophan 2,3-dioxygenase activity
E5CHR_03934	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5CHR_03936	COG1918	ferrous iron import across plasma membrane
E5CHR_03936	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5CHR_03939	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5CHR_03942	COG1049	propionate catabolic process, 2-methylcitrate cycle
E5CHR_03945	COG4106	trans-aconitate 2-methyltransferase activity
E5CHR_03946	COG0039	L-malate dehydrogenase activity
E5CHR_03947	COG2188	Transcriptional regulator
E5CHR_03950	COG1053	succinate dehydrogenase
E5CHR_03951	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5CHR_03952	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5CHR_03953	COG0372	Belongs to the citrate synthase family
E5CHR_03955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5CHR_03956	COG0066	3-isopropylmalate dehydratase activity
E5CHR_03957	COG0473	3-isopropylmalate dehydrogenase activity
E5CHR_03958	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5CHR_03960	COG0101	tRNA pseudouridine synthase activity
E5CHR_03961	COG0135	phosphoribosylanthranilate isomerase activity
E5CHR_03962	COG0133	tryptophan synthase activity
E5CHR_03963	COG0159	tryptophan synthase activity
E5CHR_03964	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5CHR_03965	COG0762	integral membrane protein
E5CHR_03967	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5CHR_03968	COG0443	Heat shock 70 kDa protein
E5CHR_03969	COG1451	nucleotide metabolic process
E5CHR_03970	COG1472	Belongs to the glycosyl hydrolase 3 family
E5CHR_03971	COG0736	holo-[acyl-carrier-protein] synthase activity
E5CHR_03972	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5CHR_03973	COG1381	Involved in DNA repair and RecF pathway recombination
E5CHR_03974	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5CHR_03975	COG0571	ribonuclease III activity
E5CHR_03977	COG0681	Belongs to the peptidase S26 family
E5CHR_03978	COG0481	GTPase activity
E5CHR_03979	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_03984	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5CHR_03985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5CHR_03986	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_03987	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5CHR_03988	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5CHR_03989	COG0416	fatty acid biosynthetic process
E5CHR_03990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5CHR_03991	COG1399	metal-binding, possibly nucleic acid-binding protein
E5CHR_03992	COG0424	maF-like protein
E5CHR_03993	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5CHR_03994	COG2223	nitrite transmembrane transporter activity
E5CHR_03999	COG1530	ribonuclease E activity
E5CHR_04002	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5CHR_04006	COG0297	glycogen (starch) synthase activity
E5CHR_04007	COG3206	protein involved in exopolysaccharide biosynthesis
E5CHR_04007	COG0489	protein tyrosine kinase activity
E5CHR_04014	COG0181	hydroxymethylbilane synthase activity
E5CHR_04015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5CHR_04017	COG3459	Glycosyltransferase 36 associated
E5CHR_04020	COG3275	phosphorelay sensor kinase activity
E5CHR_04021	COG0165	Argininosuccinate lyase
E5CHR_04029	COG0438	transferase activity, transferring glycosyl groups
E5CHR_04032	COG2197	response regulator
E5CHR_04037	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5CHR_04039	COG0583	DNA-binding transcription factor activity
E5CHR_04040	COG4948	Mandelate Racemase Muconate Lactonizing
E5CHR_04042	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5CHR_04044	COG0477	Major facilitator Superfamily
E5CHR_04046	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5CHR_04052	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5CHR_04052	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5CHR_04055	COG3022	response to hydroperoxide
E5CHR_04056	COG0525	valine-tRNA ligase activity
E5CHR_04059	COG0425	Belongs to the sulfur carrier protein TusA family
E5CHR_04060	COG2816	NAD+ diphosphatase activity
E5CHR_04064	COG3706	GGDEF domain
E5CHR_04064	COG4251	negative regulation of phosphorylation
E5CHR_04064	COG5001	Diguanylate cyclase
E5CHR_04064	COG2203	Gaf domain
E5CHR_04066	COG5001	Diguanylate cyclase
E5CHR_04066	COG5002	protein histidine kinase activity
E5CHR_04066	COG3447	MASE1 domain protein
E5CHR_04067	COG2204	response regulator
E5CHR_04074	COG1222	aaa ATPase
E5CHR_04096	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5CHR_04097	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5CHR_04098	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5CHR_04099	COG1674	ftsk spoiiie
E5CHR_04101	COG0492	ferredoxin-NADP+ reductase activity
E5CHR_04102	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5CHR_04103	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5CHR_04105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5CHR_04105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5CHR_04107	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5CHR_04108	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04115	COG0196	riboflavin kinase activity
E5CHR_04117	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5CHR_04118	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5CHR_04119	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5CHR_04121	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04123	COG0405	Gamma-glutamyltransferase
E5CHR_04124	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04125	COG0583	DNA-binding transcription factor activity
E5CHR_04128	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5CHR_04129	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5CHR_04132	COG0084	hydrolase, TatD family'
E5CHR_04133	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_04134	COG0714	Associated with various cellular activities
E5CHR_04136	COG2304	oxidoreductase activity
E5CHR_04138	COG1959	2 iron, 2 sulfur cluster binding
E5CHR_04141	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5CHR_04142	COG0038	chloride channel
E5CHR_04145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E5CHR_04146	COG1737	Transcriptional regulator
E5CHR_04151	COG0601	transmembrane transport
E5CHR_04153	COG0251	oxidation-reduction process
E5CHR_04154	COG1201	RNA secondary structure unwinding
E5CHR_04156	COG1573	uracil-dna glycosylase
E5CHR_04157	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5CHR_04159	COG3842	ATPase activity
E5CHR_04163	COG0045	succinate-CoA ligase (ADP-forming) activity
E5CHR_04164	COG1024	Enoyl-CoA hydratase
E5CHR_04165	COG1024	Enoyl-CoA hydratase
E5CHR_04167	COG1024	Enoyl-CoA hydratase
E5CHR_04168	COG2951	lytic endotransglycosylase activity
E5CHR_04169	COG1136	(ABC) transporter
E5CHR_04170	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5CHR_04172	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5CHR_04180	COG0784	Response regulator, receiver
E5CHR_04180	COG2198	Histidine kinase
E5CHR_04180	COG5002	protein histidine kinase activity
E5CHR_04181	COG0831	urea catabolic process
E5CHR_04183	COG0832	Belongs to the urease beta subunit family
E5CHR_04184	COG0804	urea catabolic process
E5CHR_04187	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E5CHR_04188	COG0830	nickel cation binding
E5CHR_04189	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E5CHR_04195	COG1024	Enoyl-CoA hydratase
E5CHR_04197	COG1414	Transcriptional regulator
E5CHR_04198	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04199	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5CHR_04204	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5CHR_04211	COG0402	S-adenosylhomocysteine deaminase activity
E5CHR_04212	COG0583	DNA-binding transcription factor activity
E5CHR_04213	COG1335	isochorismatase
E5CHR_04214	COG1942	4-Oxalocrotonate Tautomerase
E5CHR_04219	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5CHR_04220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_04224	COG0523	cobalamin synthesis protein
E5CHR_04227	COG4948	Mandelate Racemase Muconate Lactonizing
E5CHR_04229	COG1741	Belongs to the pirin family
E5CHR_04232	COG0583	DNA-binding transcription factor activity
E5CHR_04233	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04268	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5CHR_04269	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5CHR_04270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5CHR_04272	COG2815	serine threonine protein kinase
E5CHR_04272	COG0515	serine threonine protein kinase
E5CHR_04273	COG1561	YicC-like family, N-terminal region
E5CHR_04274	COG0194	GDP metabolic process
E5CHR_04275	COG1758	RNA polymerase activity
E5CHR_04276	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5CHR_04279	COG1285	pathogenesis
E5CHR_04285	COG2860	membrane
E5CHR_04287	COG1420	regulation of RNA biosynthetic process
E5CHR_04301	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5CHR_04302	COG0497	DNA recombination
E5CHR_04303	COG1660	Displays ATPase and GTPase activities
E5CHR_04304	COG1194	a g-specific adenine glycosylase
E5CHR_04305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5CHR_04306	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5CHR_04308	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5CHR_04309	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5CHR_04311	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5CHR_04312	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5CHR_04313	COG0193	aminoacyl-tRNA hydrolase activity
E5CHR_04315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5CHR_04317	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5CHR_04318	COG0444	Belongs to the ABC transporter superfamily
E5CHR_04319	COG4608	Belongs to the ABC transporter superfamily
E5CHR_04320	COG0747	negative chemotaxis
E5CHR_04321	COG0154	amidase activity
E5CHR_04323	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5CHR_04324	COG0673	inositol 2-dehydrogenase activity
E5CHR_04326	COG0583	DNA-binding transcription factor activity
E5CHR_04329	COG1473	amidohydrolase
E5CHR_04330	COG0747	negative chemotaxis
E5CHR_04331	COG0601	transmembrane transport
E5CHR_04333	COG0444	Belongs to the ABC transporter superfamily
E5CHR_04335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5CHR_04341	COG1957	nucleoside hydrolase
E5CHR_04342	COG0406	alpha-ribazole phosphatase activity
E5CHR_04343	COG2267	carboxylic ester hydrolase activity
E5CHR_04344	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5CHR_04345	COG1984	allophanate hydrolase subunit 2
E5CHR_04346	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E5CHR_04347	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5CHR_04348	COG0742	ribosomal rna small subunit methyltransferase
E5CHR_04349	COG0612	Peptidase, M16
E5CHR_04350	COG0612	Peptidase, M16
E5CHR_04354	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5CHR_04355	COG1999	signal sequence binding
E5CHR_04356	COG0109	protoheme IX farnesyltransferase activity
E5CHR_04362	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E5CHR_04364	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5CHR_04365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5CHR_04367	COG2226	methyltransferase
E5CHR_04368	COG1040	competence protein
E5CHR_04369	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5CHR_04372	COG0489	protein tyrosine kinase activity
E5CHR_04373	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5CHR_04377	COG1733	regulation of RNA biosynthetic process
E5CHR_04379	COG1024	Enoyl-CoA hydratase
E5CHR_04387	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04397	COG1733	regulation of RNA biosynthetic process
E5CHR_04398	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04405	COG3485	protocatechuate 3,4-dioxygenase
E5CHR_04410	COG0183	Belongs to the thiolase family
E5CHR_04411	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5CHR_04413	COG1414	Transcriptional regulator
E5CHR_04418	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5CHR_04428	COG1137	ATPase activity
E5CHR_04430	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_04433	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5CHR_04436	COG0583	DNA-binding transcription factor activity
E5CHR_04439	COG0583	DNA-binding transcription factor activity
E5CHR_04440	COG3485	protocatechuate 3,4-dioxygenase
E5CHR_04441	COG3485	protocatechuate 3,4-dioxygenase
E5CHR_04443	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5CHR_04505	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5CHR_04509	COG0583	DNA-binding transcription factor activity
E5CHR_04511	COG1473	amidohydrolase
E5CHR_04515	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04517	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04518	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04527	COG1566	PFAM secretion protein HlyD family protein
E5CHR_04529	COG0477	Major facilitator Superfamily
E5CHR_04532	COG0540	Belongs to the ATCase OTCase family
E5CHR_04533	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E5CHR_04534	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5CHR_04535	COG1678	Uncharacterized ACR, COG1678
E5CHR_04536	COG0415	Belongs to the DNA photolyase family
E5CHR_04537	COG2198	Histidine kinase
E5CHR_04537	COG0643	Histidine kinase
E5CHR_04538	COG0840	transmembrane signaling receptor activity
E5CHR_04543	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5CHR_04545	COG0138	bifunctional purine biosynthesis protein purh
E5CHR_04547	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5CHR_04548	COG1238	metal cluster binding
E5CHR_04551	COG2080	2 iron, 2 sulfur cluster binding
E5CHR_04552	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5CHR_04553	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5CHR_04554	COG0012	GTP binding
E5CHR_04555	COG0633	Ferredoxin
E5CHR_04555	COG3217	Mosc domain protein beta barrel domain protein
E5CHR_04556	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5CHR_04559	COG1024	Enoyl-CoA hydratase
E5CHR_04565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04566	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04570	COG1024	Enoyl-CoA hydratase
E5CHR_04573	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04574	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04575	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_04577	COG2084	Dehydrogenase
E5CHR_04584	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04585	COG1024	Enoyl-CoA hydratase
E5CHR_04586	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5CHR_04586	COG1902	pentaerythritol trinitrate reductase activity
E5CHR_04587	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5CHR_04588	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04590	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04591	COG0583	DNA-binding transcription factor activity
E5CHR_04592	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04593	COG1024	Enoyl-CoA hydratase
E5CHR_04594	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04595	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5CHR_04604	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5CHR_04606	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04615	COG2255	four-way junction helicase activity
E5CHR_04617	COG0632	four-way junction helicase activity
E5CHR_04618	COG1702	phosphate starvation-inducible protein PhoH
E5CHR_04619	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5CHR_04620	COG1490	D-aminoacyl-tRNA deacylase activity
E5CHR_04621	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5CHR_04622	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5CHR_04623	COG0739	heme binding
E5CHR_04624	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5CHR_04625	COG2814	Major facilitator Superfamily
E5CHR_04626	COG0316	Belongs to the HesB IscA family
E5CHR_04627	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5CHR_04628	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5CHR_04629	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5CHR_04630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5CHR_04633	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5CHR_04634	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5CHR_04638	COG1309	transcriptional regulator
E5CHR_04643	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_04649	COG1309	transcriptional regulator
E5CHR_04650	COG1024	Enoyl-CoA hydratase
E5CHR_04652	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_04655	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5CHR_04656	COG3842	ATPase activity
E5CHR_04658	COG2175	clavaminate synthase activity
E5CHR_04660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5CHR_04662	COG0477	Major facilitator Superfamily
E5CHR_04667	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5CHR_04670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5CHR_04672	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5CHR_04673	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_04674	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04677	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5CHR_04678	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5CHR_04682	COG3012	SEC-C Motif Domain Protein
E5CHR_04683	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04684	COG0183	Belongs to the thiolase family
E5CHR_04685	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E5CHR_04686	COG0288	reversible hydration of carbon dioxide
E5CHR_04687	COG0789	Transcriptional regulator
E5CHR_04690	COG0564	pseudouridine synthase activity
E5CHR_04691	COG2197	response regulator
E5CHR_04692	COG2205	protein histidine kinase activity
E5CHR_04696	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5CHR_04697	COG0751	glycine-tRNA ligase activity
E5CHR_04698	COG0752	glycyl-tRNA synthetase alpha subunit
E5CHR_04700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5CHR_04701	COG4535	Mg2 and Co2 transporter CorC
E5CHR_04703	COG1522	sequence-specific DNA binding
E5CHR_04706	COG3186	Phenylalanine-4-hydroxylase
E5CHR_04707	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_04715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_04716	COG2188	Transcriptional regulator
E5CHR_04717	COG0697	spore germination
E5CHR_04718	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5CHR_04720	COG0384	phenazine biosynthesis protein PhzF
E5CHR_04722	COG1280	lysine exporter protein (LysE YggA)
E5CHR_04724	COG3468	outer membrane autotransporter barrel domain protein
E5CHR_04724	COG3468	outer membrane autotransporter barrel domain protein
E5CHR_04729	COG1881	PFAM PEBP family protein
E5CHR_04732	COG0402	S-adenosylhomocysteine deaminase activity
E5CHR_04734	COG1609	Transcriptional regulator
E5CHR_04736	COG4232	protein-disulfide reductase activity
E5CHR_04737	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5CHR_04738	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5CHR_04739	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5CHR_04742	COG0679	Auxin Efflux Carrier
E5CHR_04743	COG0210	DNA helicase
E5CHR_04746	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5CHR_04747	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_04750	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5CHR_04751	COG1129	ABC transporter
E5CHR_04753	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04754	COG0028	Belongs to the TPP enzyme family
E5CHR_04755	COG1902	pentaerythritol trinitrate reductase activity
E5CHR_04756	COG3347	Dehydrogenase
E5CHR_04756	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04757	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5CHR_04762	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5CHR_04769	COG0402	S-adenosylhomocysteine deaminase activity
E5CHR_04770	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04773	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_04774	COG1116	anion transmembrane transporter activity
E5CHR_04774	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5CHR_04776	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04780	COG3246	L-lysine catabolic process to acetate
E5CHR_04781	COG2175	clavaminate synthase activity
E5CHR_04783	COG2175	clavaminate synthase activity
E5CHR_04788	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04789	COG3246	L-lysine catabolic process to acetate
E5CHR_04791	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_04792	COG1116	anion transmembrane transporter activity
E5CHR_04797	COG0439	Biotin carboxylase
E5CHR_04799	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04800	COG2186	Transcriptional regulator
E5CHR_04801	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04802	COG0511	ligase activity, forming carbon-carbon bonds
E5CHR_04803	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_04804	COG0431	NADPH-dependent FMN reductase
E5CHR_04810	COG1012	belongs to the aldehyde dehydrogenase family
E5CHR_04810	COG1454	alcohol dehydrogenase
E5CHR_04811	COG2175	clavaminate synthase activity
E5CHR_04816	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_04819	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04822	COG1960	acyl-CoA dehydrogenase activity
E5CHR_04824	COG1024	Enoyl-CoA hydratase
E5CHR_04826	COG0583	DNA-binding transcription factor activity
E5CHR_04827	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5CHR_04828	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04829	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5CHR_04830	COG0426	domain, Protein
E5CHR_04830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5CHR_04831	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04855	COG3451	type IV secretory pathway VirB4
E5CHR_04858	COG4962	Type ii secretion system protein e
E5CHR_04861	COG0583	DNA-binding transcription factor activity
E5CHR_04863	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5CHR_04866	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_04867	COG0445	tRNA wobble uridine modification
E5CHR_04869	COG1802	Transcriptional regulator
E5CHR_04872	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_04874	COG4670	ketone body catabolic process
E5CHR_04877	COG4959	Type IV secretory pathway protease TraF
E5CHR_04880	COG1192	Involved in chromosome partitioning
E5CHR_04886	COG1396	sequence-specific DNA binding
E5CHR_04889	COG5489	Protein of unknown function (DUF736)
E5CHR_04891	COG1475	DNA binding
E5CHR_04896	COG0582	viral genome integration into host DNA
E5CHR_04898	COG2204	response regulator
E5CHR_04899	COG5000	phosphorelay sensor kinase activity
E5CHR_04903	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5CHR_04904	COG0085	RNA polymerase activity
E5CHR_04905	COG0222	ribosome binding
E5CHR_04906	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5CHR_04907	COG0081	regulation of translation
E5CHR_04908	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5CHR_04910	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5CHR_04912	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5CHR_04916	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5CHR_04917	COG0134	indole-3-glycerol-phosphate synthase activity
E5CHR_04918	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5CHR_04919	COG1280	lysine exporter protein (LysE YggA)
E5CHR_04925	COG0546	phosphoglycolate phosphatase activity
E5CHR_04949	COG3501	Rhs element vgr protein
E5CHR_04961	COG0515	serine threonine protein kinase
E5CHR_04968	COG0154	amidase activity
E5CHR_04970	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E5CHR_04973	COG4251	negative regulation of phosphorylation
E5CHR_04989	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5CHR_04994	COG1473	amidohydrolase
E5CHR_05000	COG3265	gluconokinase activity
E5CHR_05005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5CHR_05005	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5CHR_05008	COG2967	ApaG domain
E5CHR_05010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E5CHR_05014	COG0583	DNA-binding transcription factor activity
E5CHR_05017	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5CHR_05018	COG2205	protein histidine kinase activity
E5CHR_05018	COG2198	Histidine kinase
E5CHR_05018	COG0784	Response regulator, receiver
E5CHR_05019	COG2197	response regulator
E5CHR_05022	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_05025	COG2226	methyltransferase
E5CHR_05026	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5CHR_05027	COG4948	Mandelate Racemase Muconate Lactonizing
E5CHR_05028	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5CHR_05030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5CHR_05033	COG0583	DNA-binding transcription factor activity
E5CHR_05034	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5CHR_05038	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_05042	COG0653	protein targeting
E5CHR_05043	COG0069	glutamate synthase activity
E5CHR_05045	COG0783	Belongs to the Dps family
E5CHR_05046	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5CHR_05049	COG2197	response regulator
E5CHR_05050	COG4585	Histidine kinase
E5CHR_05052	COG0784	Response regulator, receiver
E5CHR_05052	COG2205	protein histidine kinase activity
E5CHR_05053	COG3038	cytochrome b561
E5CHR_05056	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5CHR_05057	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5CHR_05058	COG1137	ATPase activity
E5CHR_05059	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5CHR_05060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5CHR_05062	COG0018	arginyl-trna synthetase
E5CHR_05068	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5CHR_05069	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5CHR_05070	COG1414	Transcriptional regulator
E5CHR_05072	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5CHR_05075	COG2205	protein histidine kinase activity
E5CHR_05075	COG0784	Response regulator, receiver
E5CHR_05082	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E5CHR_05083	COG0583	DNA-binding transcription factor activity
E5CHR_05085	COG0205	6-phosphofructokinase activity
E5CHR_05088	COG2814	Major facilitator Superfamily
E5CHR_05089	COG0121	glutamine amidotransferase
E5CHR_05090	COG0189	ligase activity
E5CHR_05091	COG3135	benzoate transporter
E5CHR_05092	COG3158	transport of potassium into the cell
E5CHR_05094	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5CHR_05096	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
E5CHR_05097	COG0495	leucyl-tRNA aminoacylation
E5CHR_05098	COG1523	belongs to the glycosyl hydrolase 13 family
E5CHR_05099	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5CHR_05100	COG0297	glycogen (starch) synthase activity
E5CHR_05101	COG0058	SHG alpha-glucan phosphorylase activity
E5CHR_05103	COG1921	L-seryl-tRNASec selenium transferase activity
E5CHR_05105	COG0492	ferredoxin-NADP+ reductase activity
E5CHR_05110	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_05112	COG1305	Transglutaminase-like
E5CHR_05113	COG0583	DNA-binding transcription factor activity
E5CHR_05116	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5CHR_05117	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5CHR_05118	COG0735	belongs to the Fur family
E5CHR_05119	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5CHR_05121	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5CHR_05122	COG0210	DNA helicase
E5CHR_05123	COG0598	Magnesium transport protein CorA
E5CHR_05127	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_05128	COG4638	Rieske (2fe-2S)
E5CHR_05129	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5CHR_05131	COG0028	Belongs to the TPP enzyme family
E5CHR_05133	COG0747	negative chemotaxis
E5CHR_05134	COG4608	Belongs to the ABC transporter superfamily
E5CHR_05135	COG0444	Belongs to the ABC transporter superfamily
E5CHR_05136	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5CHR_05137	COG0601	transmembrane transport
E5CHR_05138	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_05142	COG0745	RESPONSE REGULATOR receiver
E5CHR_05145	COG0482	sulfurtransferase activity
E5CHR_05146	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_05148	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5CHR_05150	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_05151	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E5CHR_05152	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5CHR_05153	COG2721	sulfolactate sulfo-lyase activity
E5CHR_05154	COG2721	sulfolactate sulfo-lyase activity
E5CHR_05158	COG0629	single-stranded DNA binding
E5CHR_05167	COG0745	RESPONSE REGULATOR receiver
E5CHR_05169	COG3852	Histidine kinase
E5CHR_05174	COG1902	pentaerythritol trinitrate reductase activity
E5CHR_05184	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5CHR_05186	COG0596	Alpha beta hydrolase
E5CHR_05188	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5CHR_05190	COG0583	DNA-binding transcription factor activity
E5CHR_05194	COG0583	DNA-binding transcription factor activity
E5CHR_05198	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_05200	COG5002	protein histidine kinase activity
E5CHR_05201	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E5CHR_05203	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5CHR_05204	COG1946	Acyl-CoA thioesterase
E5CHR_05205	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5CHR_05206	COG3181	Tripartite tricarboxylate transporter family receptor
E5CHR_05207	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5CHR_05210	COG0583	DNA-binding transcription factor activity
E5CHR_05212	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5CHR_05213	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E5CHR_05220	COG0284	orotidine-5'-phosphate decarboxylase activity
E5CHR_05224	COG2027	D-alanyl-D-alanine carboxypeptidase
E5CHR_05227	COG0009	L-threonylcarbamoyladenylate synthase
E5CHR_05228	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5CHR_05229	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5CHR_05230	COG3118	belongs to the thioredoxin family
E5CHR_05232	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5CHR_05235	COG0469	pyruvate kinase activity
E5CHR_05236	COG0126	phosphoglycerate kinase activity
E5CHR_05239	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5CHR_05241	COG0242	peptide deformylase activity
E5CHR_05243	COG0758	DNA mediated transformation
E5CHR_05244	COG2922	Belongs to the Smg family
E5CHR_05247	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5CHR_05248	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5CHR_05249	COG1862	Preprotein translocase
E5CHR_05250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5CHR_05251	COG0439	Biotin carboxylase
E5CHR_05252	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5CHR_05257	COG0318	PFAM AMP-dependent synthetase and ligase
E5CHR_05259	COG1960	acyl-CoA dehydrogenase activity
E5CHR_05261	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5CHR_05264	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5CHR_05264	COG1024	Enoyl-CoA hydratase
E5CHR_05269	COG1024	Enoyl-CoA hydratase
E5CHR_05270	COG2909	trisaccharide binding
E5CHR_05272	COG4948	Mandelate Racemase Muconate Lactonizing
E5CHR_05273	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5CHR_05275	COG1129	ABC transporter
E5CHR_05278	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5CHR_05280	COG0183	Belongs to the thiolase family
E5CHR_05281	COG2030	dehydratase
E5CHR_05282	COG1024	Enoyl-CoA hydratase
E5CHR_05283	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5CHR_05283	COG1024	Enoyl-CoA hydratase
E5CHR_05284	COG1024	Enoyl-CoA hydratase
E5CHR_05285	COG1960	acyl-CoA dehydrogenase activity
E5CHR_05286	COG2368	4-hydroxyphenylacetate
E5CHR_05298	COG1028	Short-chain dehydrogenase reductase Sdr
E5CHR_05300	COG1522	sequence-specific DNA binding
E5CHR_05301	COG0625	glutathione transferase activity
E5CHR_05304	COG5002	protein histidine kinase activity
E5CHR_05304	COG5001	Diguanylate cyclase
E5CHR_05309	COG0586	Pfam SNARE associated Golgi protein
E5CHR_05313	COG3622	Belongs to the hyi family
E5CHR_05314	COG3395	kinase activity
E5CHR_05315	COG2084	Dehydrogenase
E5CHR_05316	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5CHR_05317	COG1522	sequence-specific DNA binding
E5CHR_05322	COG4566	intracellular signal transduction
E5CHR_05326	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5CHR_05330	COG0625	glutathione transferase activity
E5CHR_05336	COG0861	Integral membrane protein TerC family
E5CHR_05338	COG1950	PFAM Membrane protein of
E5CHR_05340	COG4783	chaperone-mediated protein folding
E5CHR_05341	COG0315	cyclic pyranopterin monophosphate synthase activity
E5CHR_05350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5CHR_05351	COG0438	transferase activity, transferring glycosyl groups
E5CHR_05352	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5CHR_05358	COG3307	-O-antigen
E5CHR_05359	COG4969	Belongs to the N-Me-Phe pilin family
E5CHR_05363	COG0861	Integral membrane protein TerC family
E5CHR_05364	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5CHR_05365	COG0045	succinate-CoA ligase (ADP-forming) activity
E5CHR_05366	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5CHR_05367	COG2137	regulation of response to DNA damage stimulus
E5CHR_05368	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5CHR_05371	COG0642	Histidine kinase
E5CHR_05373	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E5CHR_05373	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E5CHR_05375	COG0551	DNA topoisomerase type I activity
E5CHR_05375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5CHR_05377	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5CHR_05379	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5CHR_05381	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5CHR_05382	COG0513	Belongs to the DEAD box helicase family
E5CHR_05387	COG1473	amidohydrolase
E5CHR_05389	COG0129	dihydroxy-acid dehydratase activity
E5CHR_05390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5CHR_05392	COG3842	ATPase activity
E5CHR_05395	COG3833	ABC-type maltose transport systems, permease component
E5CHR_05396	COG2982	Protein involved in outer membrane biogenesis
E5CHR_05400	COG1047	Peptidyl-prolyl cis-trans
E5CHR_05402	COG0765	amino acid transport
E5CHR_05403	COG0765	amino acid transport
E5CHR_05414	COG2814	Major facilitator Superfamily
E5CHR_05416	COG0583	DNA-binding transcription factor activity
E5CHR_05417	COG0165	Argininosuccinate lyase
E5CHR_05421	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5CHR_05422	COG0667	Aldo Keto reductase
E5CHR_05424	COG1522	sequence-specific DNA binding
E5CHR_05425	COG2423	ornithine cyclodeaminase activity
E5CHR_05427	COG2094	Belongs to the DNA glycosylase MPG family
E5CHR_05437	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5CHR_05443	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5CHR_05444	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5CHR_05445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E5CHR_05448	COG0006	proline dipeptidase activity
E5CHR_05451	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5CHR_05455	COG0281	malic enzyme
E5CHR_05455	COG0280	phosphate acetyltransferase
E5CHR_05458	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5CHR_05459	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5CHR_05460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E5CHR_05462	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5CHR_05464	COG3753	Protein conserved in bacteria
E5CHR_05465	COG2814	Major facilitator Superfamily
E5CHR_05466	COG2267	carboxylic ester hydrolase activity
E5CHR_05470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5CHR_05471	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5CHR_05472	COG0724	RNA recognition motif
E5CHR_05473	COG0300	oxidoreductase activity
E5CHR_05475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5CHR_05479	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E5CHR_05479	COG2066	Belongs to the glutaminase family
E5CHR_05480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5CHR_05481	COG0706	membrane insertase activity
E5CHR_05482	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5CHR_05483	COG0594	ribonuclease P activity
E5CHR_05484	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5P1_00001	COG1192	Involved in chromosome partitioning
E5P1_00004	COG1199	ATP-dependent helicase activity
E5P1_00037	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5P1_00048	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5P1_00053	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5P1_00054	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5P1_00062	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5P1_00063	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5P1_00117	COG4682	membrane
E5P1_00118	COG0433	COG0433 Predicted ATPase
E5P1_00137	COG0551	DNA topoisomerase type I activity
E5P1_00137	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5P1_00150	COG4974	Belongs to the 'phage' integrase family
E5P1_00184	COG0545	Peptidyl-prolyl cis-trans isomerase
E5P1_00186	COG2954	triphosphatase activity
E5P1_00204	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5P1_00211	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5P1_00223	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5P1_00227	COG3011	Protein conserved in bacteria
E5P1_00246	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5P1_00268	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E5P1_00270	COG0215	cysteine-tRNA ligase activity
E5P1_00319	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5P1_00338	COG1074	ATP-dependent DNA helicase activity
E5P1_00345	COG4286	Uncharacterised protein family (UPF0160)
E5P1_00353	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5P1_00353	COG0519	Catalyzes the synthesis of GMP from XMP
E5P1_00357	COG0519	Catalyzes the synthesis of GMP from XMP
E5P1_00357	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5P1_00366	COG2801	Transposase and inactivated derivatives
E5P1_00368	COG3181	Tripartite tricarboxylate transporter family receptor
E5P1_00372	COG1454	alcohol dehydrogenase
E5P1_00375	COG3181	Tripartite tricarboxylate transporter family receptor
E5P1_00376	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5P1_00382	COG1484	DNA-dependent DNA replication
E5P1_00387	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5P1_00425	COG4650	regulator
E5P1_00441	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5P1_00446	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5P1_00497	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5P1_00501	COG4637	Psort location Cytoplasmic, score
E5P1_00508	COG1518	maintenance of DNA repeat elements
E5P1_00509	COG1203	CRISPR-associated helicase, Cas3
E5P1_00510	COG0587	DNA-directed DNA polymerase activity
E5P1_00524	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5P1_00534	COG0084	hydrolase, TatD family'
E5P1_00592	COG2268	Band 7 protein
E5P1_00597	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5P1_00603	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5P1_00605	COG0628	permease
E5P1_00607	COG1129	ABC transporter
E5P1_00614	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E5P1_00627	COG0675	Transposase, IS605 OrfB family
E5P1_00635	COG1222	aaa ATPase
E5P1_00636	COG1199	ATP-dependent helicase activity
E5P1_00646	COG0557	exoribonuclease II activity
E5P1_00664	COG0617	tRNA 3'-terminal CCA addition
E5P1_00667	COG1056	cytidyltransferase-related domain
E5P1_00667	COG1051	belongs to the nudix hydrolase family
E5P1_00671	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5P1_00671	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5P1_00679	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5P1_00694	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E5P1_00704	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5P1_00705	COG1484	DNA-dependent DNA replication
E5P1_00709	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5P1_00715	COG0494	nUDIX hydrolase
E5P1_00730	COG4974	Belongs to the 'phage' integrase family
E5P1_00763	COG0328	RNA-DNA hybrid ribonuclease activity
E5P1_00773	COG0629	single-stranded DNA binding
E5P1_00780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5P1_00787	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5P1_00787	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5P1_00814	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5P1_00815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5P1_00823	COG0840	transmembrane signaling receptor activity
E5P1_00824	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5P1_00839	COG0582	viral genome integration into host DNA
E5P1_00863	COG0210	DNA helicase
E5P1_00871	COG0653	protein targeting
E5P1_00878	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5P1_00880	COG1484	DNA-dependent DNA replication
E5P1_00882	COG0187	DNA topoisomerase II activity
E5P1_00883	COG0741	lytic transglycosylase activity
E5P1_00883	COG1196	nuclear chromosome segregation
E5P1_00883	COG0739	heme binding
E5P1_00884	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5P1_00890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5P2_00001	COG1192	Involved in chromosome partitioning
E5P2_00006	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5P2_00007	COG0583	DNA-binding transcription factor activity
E5P2_00026	COG1960	acyl-CoA dehydrogenase activity
E5P2_00029	COG0318	PFAM AMP-dependent synthetase and ligase
E5P2_00030	COG4608	Belongs to the ABC transporter superfamily
E5P2_00031	COG2207	Transcriptional regulator
E5P2_00032	COG2175	clavaminate synthase activity
E5P2_00035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5P2_00038	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5P2_00043	COG4566	intracellular signal transduction
E5P2_00046	COG0318	PFAM AMP-dependent synthetase and ligase
E5P2_00047	COG1024	Enoyl-CoA hydratase
E5P2_00050	COG0183	Belongs to the thiolase family
E5P2_00055	COG1024	Enoyl-CoA hydratase
E5P2_00064	COG1309	transcriptional regulator
E5P2_00065	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5P2_00068	COG1024	Enoyl-CoA hydratase
E5P2_00071	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00072	COG0318	PFAM AMP-dependent synthetase and ligase
E5P2_00073	COG1960	acyl-CoA dehydrogenase activity
E5P2_00080	COG2072	flavoprotein involved in K transport
E5P2_00089	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00092	COG4566	intracellular signal transduction
E5P2_00095	COG2831	hemolysin activation secretion protein
E5P2_00100	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00102	COG4948	Mandelate Racemase Muconate Lactonizing
E5P2_00104	COG1012	belongs to the aldehyde dehydrogenase family
E5P2_00106	COG3842	ATPase activity
E5P2_00111	COG3386	PFAM SMP-30 Gluconolaconase
E5P2_00115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5P2_00117	COG2197	response regulator
E5P2_00118	COG4585	Histidine kinase
E5P2_00119	COG2205	protein histidine kinase activity
E5P2_00120	COG0667	Aldo Keto reductase
E5P2_00122	COG0765	amino acid transport
E5P2_00123	COG0765	amino acid transport
E5P2_00124	COG1126	abc transporter atp-binding protein
E5P2_00126	COG1522	sequence-specific DNA binding
E5P2_00127	COG3842	ATPase activity
E5P2_00130	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5P2_00131	COG0778	Nitroreductase
E5P2_00131	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E5P2_00132	COG1920	GTP binding
E5P2_00133	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5P2_00134	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E5P2_00135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E5P2_00136	COG0251	oxidation-reduction process
E5P2_00138	COG0523	cobalamin synthesis protein
E5P2_00142	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5P2_00144	COG1414	Transcriptional regulator
E5P2_00149	COG3268	Saccharopine dehydrogenase
E5P2_00150	COG0318	PFAM AMP-dependent synthetase and ligase
E5P2_00152	COG0183	Belongs to the thiolase family
E5P2_00153	COG0604	alcohol dehydrogenase
E5P2_00158	COG1024	Enoyl-CoA hydratase
E5P2_00159	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5P2_00160	COG2814	Major facilitator Superfamily
E5P2_00164	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E5P2_00166	COG0583	DNA-binding transcription factor activity
E5P2_00170	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00172	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00173	COG1053	succinate dehydrogenase
E5P2_00176	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00178	COG0165	Argininosuccinate lyase
E5P2_00179	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5P2_00181	COG0765	amino acid transport
E5P2_00182	COG0010	Belongs to the arginase family
E5P2_00184	COG0579	oxidoreductase
E5P2_00188	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E5P2_00192	COG1335	isochorismatase
E5P2_00195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5P2_00197	COG0791	NLP P60 protein
E5P2_00199	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5P2_00205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5P2_00206	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5P2_00211	COG3386	PFAM SMP-30 Gluconolaconase
E5P2_00212	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5P2_00214	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5P2_00216	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5P2_00221	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5P2_00223	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5P2_00224	COG0439	Biotin carboxylase
E5P2_00226	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00231	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5P2_00234	COG0066	3-isopropylmalate dehydratase activity
E5P2_00235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5P2_00236	COG0277	FAD linked oxidase domain protein
E5P2_00236	COG0247	lactate metabolic process
E5P2_00240	COG0028	Belongs to the TPP enzyme family
E5P2_00251	COG0625	glutathione transferase activity
E5P2_00260	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00261	COG0583	DNA-binding transcription factor activity
E5P2_00262	COG0604	alcohol dehydrogenase
E5P2_00264	COG1024	Enoyl-CoA hydratase
E5P2_00266	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5P2_00274	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5P2_00275	COG1414	Transcriptional regulator
E5P2_00279	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5P2_00280	COG0586	Pfam SNARE associated Golgi protein
E5P2_00282	COG1672	PFAM Archaeal ATPase
E5P2_00282	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E5P2_00286	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00287	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00290	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5P2_00291	COG3842	ATPase activity
E5P2_00292	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5P2_00297	COG0439	Biotin carboxylase
E5P2_00298	COG0511	ligase activity, forming carbon-carbon bonds
E5P2_00300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5P2_00301	COG2721	sulfolactate sulfo-lyase activity
E5P2_00304	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E5P2_00305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5P2_00306	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5P2_00310	COG0445	tRNA wobble uridine modification
E5P2_00311	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00313	COG1960	acyl-CoA dehydrogenase activity
E5P2_00317	COG0318	PFAM AMP-dependent synthetase and ligase
E5P2_00318	COG1414	Transcriptional regulator
E5P2_00324	COG2079	MmgE PrpD family protein
E5P2_00325	COG1053	succinate dehydrogenase
E5P2_00326	COG2079	MmgE PrpD family protein
E5P2_00327	COG0523	cobalamin synthesis protein
E5P2_00329	COG1335	isochorismatase
E5P2_00331	COG3550	peptidyl-serine autophosphorylation
E5P2_00332	COG1760	l-serine dehydratase
E5P2_00334	COG1335	isochorismatase
E5P2_00337	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5P2_00338	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E5P2_00360	COG2207	Transcriptional regulator
E5P2_00361	COG0789	Transcriptional regulator
E5P2_00370	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00371	COG0235	Class ii aldolase
E5P2_00372	COG1024	Enoyl-CoA hydratase
E5P2_00374	COG3119	arylsulfatase activity
E5P2_00382	COG3284	Transcriptional regulator
E5P2_00384	COG1917	Cupin 2, conserved barrel domain protein
E5P2_00386	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00388	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5P2_00389	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E5P2_00392	COG0583	DNA-binding transcription factor activity
E5P2_00393	COG0583	DNA-binding transcription factor activity
E5P2_00396	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00397	COG2814	Major facilitator Superfamily
E5P2_00400	COG3639	organic phosphonate transmembrane transporter activity
E5P2_00401	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E5P2_00402	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E5P2_00403	COG3454	Phosphonate metabolism
E5P2_00404	COG4778	phosphonate C-P lyase system protein PhnL
E5P2_00405	COG4107	phosphonate C-P lyase system protein PhnK
E5P2_00406	COG3627	carbon phosphorus lyase activity
E5P2_00407	COG3626	phosphonate metabolism
E5P2_00409	COG3624	Phosphonate C-P lyase system protein PhnG
E5P2_00410	COG1609	Transcriptional regulator
E5P2_00411	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E5P2_00412	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E5P2_00419	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5P2_00420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5P2_00422	COG1045	serine acetyltransferase
E5P2_00429	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5P2_00430	COG0583	DNA-binding transcription factor activity
E5P2_00433	COG1175	transmembrane transport
E5P2_00435	COG3842	ATPase activity
E5P2_00443	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5P2_00446	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00452	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5P2_00453	COG1960	acyl-CoA dehydrogenase activity
E5P2_00456	COG0183	Belongs to the thiolase family
E5P2_00457	COG2030	dehydratase
E5P2_00459	COG0583	DNA-binding transcription factor activity
E5P2_00460	COG1053	succinate dehydrogenase
E5P2_00460	COG0431	NADPH-dependent FMN reductase
E5P2_00460	COG3976	FMN-binding domain protein
E5P2_00469	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00470	COG1802	Transcriptional regulator
E5P2_00471	COG1024	Enoyl-CoA hydratase
E5P2_00474	COG1960	acyl-CoA dehydrogenase activity
E5P2_00475	COG1960	acyl-CoA dehydrogenase activity
E5P2_00477	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5P2_00478	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5P2_00482	COG3181	Tripartite tricarboxylate transporter family receptor
E5P2_00486	COG1960	acyl-CoA dehydrogenase activity
E5P2_00490	COG1024	Enoyl-CoA hydratase
E5P2_00492	COG1902	pentaerythritol trinitrate reductase activity
E5P2_00493	COG1024	Enoyl-CoA hydratase
E5P2_00494	COG1960	acyl-CoA dehydrogenase activity
E5P2_00496	COG1024	Enoyl-CoA hydratase
E5P2_00497	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5P2_00498	COG1960	acyl-CoA dehydrogenase activity
E5P2_00499	COG1960	acyl-CoA dehydrogenase activity
E5P2_00500	COG1024	Enoyl-CoA hydratase
E5P2_00501	COG0318	PFAM AMP-dependent synthetase and ligase
E5P2_00506	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00507	COG1024	Enoyl-CoA hydratase
E5P2_00510	COG1960	acyl-CoA dehydrogenase activity
E5P2_00511	COG1960	acyl-CoA dehydrogenase activity
E5P2_00512	COG1024	Enoyl-CoA hydratase
E5P2_00513	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00514	COG2030	dehydratase
E5P2_00516	COG0583	DNA-binding transcription factor activity
E5P2_00517	COG1028	Short-chain dehydrogenase reductase Sdr
E5P2_00518	COG2070	2-Nitropropane dioxygenase
E5P2_00519	COG2130	NADP-dependent
E5P2_00523	COG0651	ATP synthesis coupled electron transport
E5P2_00526	COG0651	ATP synthesis coupled electron transport
E5P2_00527	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5P2_00527	COG0649	NAD binding
E5P2_00527	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5P2_00528	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5P2_00534	COG0651	ATP synthesis coupled electron transport
E5P2_00535	COG0650	Formate hydrogenlyase subunit 4
E5P2_00537	COG0651	ATP synthesis coupled electron transport
E5P2_00538	COG3261	NADH dehydrogenase
E5P2_00538	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E5P2_00539	COG3260	NADH ubiquinone oxidoreductase 20
E5P2_00544	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5P2_00545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5P3_00005	COG0517	IMP dehydrogenase activity
E5P3_00008	COG0517	IMP dehydrogenase activity
E5P3_00017	COG4584	PFAM Integrase catalytic
E5P3_00018	COG1484	DNA-dependent DNA replication
E5P3_00043	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5P3_00047	COG1121	(ABC) transporter
E5P3_00062	COG3701	Conjugal transfer protein
E5P3_00063	COG3451	type IV secretory pathway VirB4
E5P3_00064	COG5268	conjugation
E5P3_00065	COG3838	Conjugal transfer protein Trbc
E5P3_00066	COG4962	Type ii secretion system protein e