locus-tag class description H6CHR_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) H6CHR_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H6CHR_00003 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H6CHR_00006 ENOG4107RN3 metallophosphoesterase H6CHR_00008 ENOG41061N2 exported protein H6CHR_00011 ENOG4107UXM Membrane H6CHR_00012 ENOG4105DZQ phospholipase D Transphosphatidylase H6CHR_00013 ENOG4105X23 Endonuclease Exonuclease phosphatase H6CHR_00017 ENOG4105EUB pirin domain protein H6CHR_00018 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase H6CHR_00022 ENOG4108JQC penicillin-binding protein 1A H6CHR_00025 ENOG4105EB3 Histidine kinase H6CHR_00026 ENOG4105E3W Two component transcriptional regulator (Winged helix family H6CHR_00028 ENOG410681U heavy metal transport detoxification protein H6CHR_00030 ENOG4105ECM Sensor protein basS pmrB H6CHR_00031 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H6CHR_00032 ENOG4105CBP Major Facilitator H6CHR_00033 ENOG4108K3A Glutathione S-transferase H6CHR_00036 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H6CHR_00037 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) H6CHR_00039 ENOG4107QJE Chromosome Partitioning Protein H6CHR_00041 ENOG4105FA0 parb-like partition protein H6CHR_00043 ENOG4105CQB FAD linked oxidase domain protein H6CHR_00044 ENOG4108WBT adenosyltransferase H6CHR_00052 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) H6CHR_00053 ENOG4107QMS site-determining protein H6CHR_00054 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) H6CHR_00056 ENOG4105C2W permease H6CHR_00057 ENOG4105KA0 thioesterase Superfamily protein H6CHR_00060 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H6CHR_00061 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_00067 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) H6CHR_00068 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme H6CHR_00073 ENOG4105F8J Adenylate Guanylate cyclase H6CHR_00075 ENOG4108Z9W Outer membrane porin H6CHR_00076 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H6CHR_00079 ENOG4105E2B Taurine dioxygenase H6CHR_00083 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) H6CHR_00088 ENOG4107QMH DNA methylase H6CHR_00090 ENOG4108IV0 ABC, transporter H6CHR_00091 ENOG4105C0Z ABC transporter H6CHR_00093 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_00095 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H6CHR_00099 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H6CHR_00104 ENOG41068W2 Cytochrome p-450 H6CHR_00105 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H6CHR_00106 ENOG4108X7A Terpene synthase metal-binding domain-containing protein H6CHR_00110 ENOG4105BZU Histidine kinase H6CHR_00111 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H6CHR_00113 ENOG4105DTD Dehydrogenase H6CHR_00119 ENOG41082JN Transcriptional regulator H6CHR_00127 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H6CHR_00130 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H6CHR_00139 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H6CHR_00140 ENOG4105F38 ABC transporter, permease H6CHR_00141 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component H6CHR_00144 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) H6CHR_00147 ENOG4107S9D Alpha beta hydrolase H6CHR_00152 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_00154 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H6CHR_00159 ENOG4105K4H Nlp p60 protein H6CHR_00161 ENOG4107R6F Alpha Beta Hydrolase Fold protein H6CHR_00162 ENOG4105BZU Histidine kinase H6CHR_00163 ENOG4108KSA LysR family transcriptional regulator H6CHR_00164 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H6CHR_00166 ENOG4105E39 Enoyl-CoA hydratase H6CHR_00168 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_00172 ENOG4105DQE DNA ligase H6CHR_00174 ENOG4105FDF Could be involved in DNA repair (By similarity) H6CHR_00175 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H6CHR_00176 ENOG4107JEE Short-chain dehydrogenase reductase Sdr H6CHR_00177 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) H6CHR_00179 ENOG4105VYA Uncharacterized conserved protein (DUF2132) H6CHR_00182 ENOG4108SKZ Patatin-like phospholipase H6CHR_00187 ENOG4105KWG Pfam:DUF1696 H6CHR_00189 ENOG4108V1U phospholipid-binding protein H6CHR_00198 ENOG4107RSM transcriptional regulator H6CHR_00199 ENOG4108Z4U Ferredoxin H6CHR_00203 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_00207 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H6CHR_00210 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H6CHR_00211 ENOG4105F27 Major Facilitator H6CHR_00212 ENOG41086DT Membrane protein of unknown function H6CHR_00216 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H6CHR_00217 ENOG4105D3R alkyl hydroperoxide reductase H6CHR_00218 ENOG4105ETT transcriptional Regulator, LysR family H6CHR_00219 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_00220 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_00224 ENOG4105EMU Dehydrogenase H6CHR_00231 ENOG4105ETE Transcriptional regulator (LacI family H6CHR_00233 ENOG4106PBJ Serine threonine-protein kinase Pkn6 H6CHR_00236 ENOG4105CSV Glutaminase H6CHR_00239 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) H6CHR_00245 ENOG4105DGI Alkaline phosphatase H6CHR_00250 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) H6CHR_00252 ENOG4105C7B Threonine dehydratase H6CHR_00253 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H6CHR_00256 ENOG4105C9U ATP-dependent DNA helicase RecQ H6CHR_00261 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H6CHR_00263 ENOG4105CZE histidine utilization repressor H6CHR_00264 ENOG4105C84 Histidine ammonia-lyase H6CHR_00265 ENOG4105CGP Urocanate hydratase H6CHR_00270 ENOG4105CI2 imidazolone-5-propionate hydrolase H6CHR_00276 ENOG4105C3R Methionine synthase H6CHR_00278 ENOG4105F52 Transcriptional regulator H6CHR_00280 ENOG4105C3R Methionine synthase H6CHR_00281 ENOG41063ZV H6CHR_00282 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 H6CHR_00286 ENOG4108W9H Tetr family transcriptional regulator H6CHR_00287 ENOG4105DP0 ferredoxin-NADP reductase H6CHR_00295 ENOG4105C0Z ABC transporter H6CHR_00296 ENOG4108IV0 ABC, transporter H6CHR_00297 ENOG4108RWI nicotinamidase H6CHR_00298 ENOG4108XHQ (2Fe-2S)-binding domain protein H6CHR_00299 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding H6CHR_00301 ENOG4105CP9 extracellular ligand-binding receptor H6CHR_00302 ENOG4105C0P Mg chelatase subunit ChlI H6CHR_00310 ENOG4108YZA Nitrogen regulatory protein pii H6CHR_00311 ENOG4105BZU Histidine kinase H6CHR_00313 ENOG4105EU8 FAD linked oxidase domain protein H6CHR_00314 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H6CHR_00317 ENOG4108V06 Glutathione peroxidase H6CHR_00319 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) H6CHR_00320 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H6CHR_00322 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H6CHR_00323 ENOG4105MP9 class II Aldolase H6CHR_00325 ENOG4105C01 Dihydroxy-acid dehydratase H6CHR_00329 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase H6CHR_00330 ENOG4105C26 Dehydrogenase H6CHR_00334 ENOG4108V8F Transcriptional regulator, MarR family H6CHR_00335 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H6CHR_00338 ENOG4105DH7 May be involved in recombination (By similarity) H6CHR_00339 ENOG4105CM2 brancheD-chain amino acid aminotransferase H6CHR_00342 ENOG4105E0F Histidine kinase H6CHR_00343 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H6CHR_00351 ENOG4105EMU Dehydrogenase H6CHR_00353 ENOG41061H0 Monooxygenase H6CHR_00354 ENOG4105F04 LysR family Transcriptional regulator H6CHR_00355 ENOG4105CGK Exodeoxyribonuclease III H6CHR_00356 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) H6CHR_00358 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H6CHR_00359 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H6CHR_00360 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H6CHR_00364 ENOG4105CJN penicillin-binding protein H6CHR_00367 ENOG4105DHJ ABC, transporter H6CHR_00371 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H6CHR_00372 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H6CHR_00376 ENOG4105D52 delta-aminolevulinic acid dehydratase H6CHR_00377 ENOG4108YXA Membrane H6CHR_00379 ENOG4105NZG Ferredoxin H6CHR_00380 ENOG4105DHZ alpha beta H6CHR_00381 ENOG4105DZ1 carboxypeptidase H6CHR_00382 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H6CHR_00383 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H6CHR_00384 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H6CHR_00385 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H6CHR_00386 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) H6CHR_00389 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H6CHR_00390 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H6CHR_00391 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) H6CHR_00392 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H6CHR_00393 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) H6CHR_00394 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) H6CHR_00395 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H6CHR_00396 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) H6CHR_00397 ENOG41084PQ 50s ribosomal protein l29 H6CHR_00398 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H6CHR_00402 ENOG4105T86 cytochrome C H6CHR_00403 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H6CHR_00406 ENOG41080Z8 PHOSPHOCARRIER protein H6CHR_00407 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H6CHR_00410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H6CHR_00411 ENOG4105E0F Histidine kinase H6CHR_00412 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H6CHR_00415 ENOG4105F4P )-transporter H6CHR_00416 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_00417 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H6CHR_00418 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) H6CHR_00419 ENOG4108Z43 UPF0250 protein H6CHR_00420 ENOG4105F0I Aminotransferase H6CHR_00422 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) H6CHR_00423 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H6CHR_00424 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H6CHR_00425 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H6CHR_00426 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H6CHR_00427 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H6CHR_00428 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H6CHR_00429 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H6CHR_00431 ENOG4105C2J ABC transporter H6CHR_00432 ENOG4105CNN ABC, transporter H6CHR_00433 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H6CHR_00434 ENOG4105CIB oxidoreductase Domain protein H6CHR_00441 ENOG4108DWA Nad synthetase H6CHR_00444 ENOG4107T0X DNA ligase H6CHR_00445 ENOG4107T0X DNA ligase H6CHR_00446 ENOG4107QRT dEAD DEAH box helicase H6CHR_00457 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H6CHR_00458 ENOG4105BZS acriflavin resistance protein H6CHR_00459 ENOG4105C1P efflux transporter, rnd family, mfp subunit H6CHR_00460 ENOG4108IG5 Transcriptional regulator H6CHR_00462 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H6CHR_00463 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H6CHR_00465 ENOG4108TGY Glutathione S-transferase H6CHR_00467 ENOG4105DTQ mandelate racemase muconate lactonizing H6CHR_00470 ENOG4108W5M transcriptional regulator H6CHR_00471 ENOG4105CQB FAD linked oxidase domain protein H6CHR_00472 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_00473 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_00474 ENOG4105GVF (ABC) transporter H6CHR_00477 ENOG4105CI2 imidazolone-5-propionate hydrolase H6CHR_00478 ENOG4105CKI cobalamin synthesis protein H6CHR_00479 ENOG4105DND Transcriptional regulator H6CHR_00481 ENOG4105DTQ mandelate racemase muconate lactonizing H6CHR_00485 ENOG4105CKI cobalamin synthesis protein H6CHR_00487 ENOG4108WYP Transcriptional regulator H6CHR_00489 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_00495 ENOG41069HH 4-oxalocrotonate tautomerase H6CHR_00496 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) H6CHR_00497 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H6CHR_00498 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H6CHR_00499 ENOG4105MWK D-amino acid dehydrogenase, small subunit H6CHR_00501 ENOG4107EXU Short-chain dehydrogenase reductase Sdr H6CHR_00505 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein H6CHR_00508 ENOG4105C26 Dehydrogenase H6CHR_00509 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator H6CHR_00510 ENOG4105DFW ABC transporter H6CHR_00512 ENOG4108HWW ABC transporter H6CHR_00513 ENOG4105C2J ABC transporter H6CHR_00514 ENOG4107R9N ABC transporter H6CHR_00515 ENOG41062B0 ABC transporter, permease H6CHR_00522 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H6CHR_00523 ENOG41082RQ UPF0102 protein H6CHR_00524 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H6CHR_00526 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H6CHR_00527 ENOG4105CZX twitching motility protein H6CHR_00528 ENOG4105CZX twitching motility protein H6CHR_00529 ENOG4105DFA alanine racemase domain protein H6CHR_00530 ENOG4105C26 Dehydrogenase H6CHR_00531 ENOG4105D82 Glutamate dehydrogenase H6CHR_00535 ENOG4105CYW agmatinase H6CHR_00537 ENOG4105S7S phosphonate abc transporter H6CHR_00538 ENOG4105D5T phosphonate abc transporter H6CHR_00539 ENOG4105EHI Phosphonate ABC transporter, periplasmic H6CHR_00540 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process H6CHR_00542 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) H6CHR_00545 ENOG4105U5Y Transcriptional regulator H6CHR_00548 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H6CHR_00551 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_00552 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H6CHR_00555 ENOG41067MG lrgb family H6CHR_00556 ENOG4105VAW lrga family H6CHR_00557 ENOG4105CQB FAD linked oxidase domain protein H6CHR_00559 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H6CHR_00565 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase H6CHR_00575 ENOG4105CH2 amidohydrolase H6CHR_00581 ENOG4105MH5 phosphoesterase PA-phosphatase related protein H6CHR_00588 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) H6CHR_00589 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H6CHR_00590 ENOG4105CB5 ATP-dependent DNA helicase recG H6CHR_00591 ENOG4105C5Q Transcriptional regulator H6CHR_00593 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) H6CHR_00594 ENOG4105II7 pyrroline-5-carboxylate reductase H6CHR_00595 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) H6CHR_00596 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H6CHR_00597 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits H6CHR_00598 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H6CHR_00599 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H6CHR_00600 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H6CHR_00601 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H6CHR_00602 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H6CHR_00603 ENOG4105VPB 50S ribosomal protein L30 H6CHR_00604 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) H6CHR_00605 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H6CHR_00606 ENOG41067V7 50S ribosomal protein L36 H6CHR_00607 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H6CHR_00608 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) H6CHR_00609 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H6CHR_00610 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H6CHR_00611 ENOG4108ZT0 50S ribosomal protein l17 H6CHR_00615 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_00619 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H6CHR_00622 ENOG4105EJC lysr family transcriptional regulator H6CHR_00623 ENOG4105F6U Short-chain dehydrogenase reductase Sdr H6CHR_00624 ENOG4105CPP Dehydrogenase, E1 component H6CHR_00625 ENOG4107RUY (E1 component), alpha subunit H6CHR_00633 ENOG4107R7Y intracellular protease Pfpi family H6CHR_00635 ENOG4105DZS Phenylacetate-CoA ligase H6CHR_00636 ENOG4108IV0 ABC, transporter H6CHR_00640 ENOG4105C0Z ABC transporter H6CHR_00641 ENOG4108IQE Amp-dependent synthetase and ligase H6CHR_00642 ENOG4105IJJ transcriptional regulator, crp fnr family H6CHR_00644 ENOG410904N short-chain dehydrogenase reductase H6CHR_00649 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H6CHR_00650 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H6CHR_00651 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) H6CHR_00652 ENOG4105C08 Histidine kinase H6CHR_00653 ENOG4105EEX Two component transcriptional regulator (Winged helix family H6CHR_00655 ENOG4105FE9 pseudouridine synthase H6CHR_00656 ENOG4105XJC Two component transcriptional regulator (Winged helix family H6CHR_00657 ENOG4105DHQ Histidine kinase H6CHR_00667 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H6CHR_00668 ENOG4106A3M Cytochrome p-450 H6CHR_00669 ENOG4105E27 serine threonine protein kinase H6CHR_00671 ENOG4108ZHJ Organic hydroperoxide resistance protein H6CHR_00672 ENOG4105K56 Transcriptional regulator H6CHR_00674 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H6CHR_00675 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H6CHR_00679 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H6CHR_00683 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_00685 ENOG4105C0Z ABC transporter H6CHR_00686 ENOG4108IV0 ABC, transporter H6CHR_00694 ENOG4107S78 Band 7 protein H6CHR_00696 ENOG4105EQN UPF0261 protein H6CHR_00697 ENOG4105C0Z ABC transporter H6CHR_00701 ENOG4105CI2 imidazolone-5-propionate hydrolase H6CHR_00702 ENOG4105CI2 imidazolone-5-propionate hydrolase H6CHR_00703 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) H6CHR_00704 ENOG4105ERH Fumarylacetoacetate hydrolase H6CHR_00710 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) H6CHR_00711 ENOG4109066 lysm domain bon superfamily protein H6CHR_00713 ENOG4105CH5 extracellular solute-binding protein, family 7 H6CHR_00715 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_00715 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_00721 ENOG4105DC8 reductase H6CHR_00724 ENOG4105FYV Amp nucleosidase H6CHR_00726 ENOG4108ZHR arsR family transcriptional regulator H6CHR_00730 ENOG4105EJC lysr family transcriptional regulator H6CHR_00731 ENOG4105CJ1 ABC, transporter H6CHR_00734 ENOG4106BRA Membrane H6CHR_00736 ENOG4105CH2 amidohydrolase H6CHR_00739 ENOG4108J2R molybdopterin oxidoreductase H6CHR_00751 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase H6CHR_00752 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H6CHR_00753 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H6CHR_00757 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H6CHR_00761 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) H6CHR_00763 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H6CHR_00766 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H6CHR_00777 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H6CHR_00780 ENOG4105C0K Gdp-mannose 4,6-dehydratase H6CHR_00783 ENOG4105C30 Nad-dependent epimerase dehydratase H6CHR_00788 ENOG4105CJT Mannose-1-phosphate guanylyltransferase H6CHR_00789 ENOG4105EXC Acyl-transferase H6CHR_00794 ENOG4105CAS nag kinase H6CHR_00796 ENOG4105CMR udp-glucose 4-epimerase H6CHR_00800 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H6CHR_00803 ENOG4105DZG Dehydrogenase H6CHR_00804 ENOG4105IPI Membrane H6CHR_00807 ENOG4108ZCF integral membrane protein H6CHR_00810 ENOG4106P55 Transcriptional regulator H6CHR_00812 ENOG4105CQB FAD linked oxidase domain protein H6CHR_00814 ENOG4105MIR Phenylalanine 4-monooxygenase H6CHR_00815 ENOG4105KZX Pterin carbinolamine dehydratase H6CHR_00817 ENOG4105J0Q Transcriptional regulator H6CHR_00819 ENOG4105CYM Glutathione S-transferase H6CHR_00820 ENOG4105F95 Monooxygenase H6CHR_00821 ENOG4105YVM Phosphoesterase, PA-phosphatase related H6CHR_00824 ENOG4105BZU Histidine kinase H6CHR_00825 ENOG4105DG4 malate L-lactate dehydrogenase H6CHR_00826 ENOG4105CTX dehydratase H6CHR_00827 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_00829 ENOG4108ERU trap dicarboxylate transporter subunit DctP H6CHR_00830 ENOG4107YCY Transcriptional regulator H6CHR_00831 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H6CHR_00832 ENOG4106517 Short-chain dehydrogenase reductase Sdr H6CHR_00834 ENOG4105C26 Dehydrogenase H6CHR_00835 ENOG4105EXG Transcriptional regulator H6CHR_00837 ENOG4105CSU acyl-Coa dehydrogenase H6CHR_00840 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_00842 ENOG41060WC Enoyl-CoA hydratase H6CHR_00843 ENOG4105NAU thioesterase Superfamily protein H6CHR_00844 ENOG4108JJ7 ABC transporter H6CHR_00845 ENOG4105C5I Dehydrogenase H6CHR_00847 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_00848 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H6CHR_00849 ENOG4105C0Z ABC transporter H6CHR_00850 ENOG4108IV0 ABC, transporter H6CHR_00852 ENOG4105RE0 Asp Glu hydantoin racemase H6CHR_00855 ENOG4108UAU isochorismatase H6CHR_00857 ENOG4107YNJ LysR family Transcriptional regulator H6CHR_00858 ENOG4107RP9 extracellular solute-binding protein, family 3 H6CHR_00859 ENOG4105EAD ABC transporter H6CHR_00860 ENOG4105DRP amino acid AbC transporter H6CHR_00861 ENOG4105CDA abc transporter atp-binding protein H6CHR_00862 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_00863 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_00865 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_00866 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_00867 ENOG4105CC9 acyl-Coa dehydrogenase H6CHR_00868 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_00869 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H6CHR_00870 ENOG4105CBN LysR family transcriptional regulator H6CHR_00871 ENOG4105EQ1 Transcriptional regulator H6CHR_00872 ENOG4105CHJ isochorismatase hydrolase H6CHR_00874 ENOG4105EFZ amidohydrolase H6CHR_00878 ENOG4105W5Q DNA repair protein (RadC H6CHR_00879 ENOG4105EKE dihydroorotase H6CHR_00883 ENOG4108U57 Involved in the degradation of terephthalate (TPA) via the protocatechuate (PCA) 4,5-cleavage pathway. Catalyzes the dehydrogenation of 1,2-dihydroxy-3,5-cyclohexadiene-1,4- dicarboxylate (DCD) to yield protocatechuate (PCA) (By similarity) H6CHR_00887 ENOG4107HP6 Transcriptional regulator H6CHR_00888 ENOG4105D0M Protease HtpX homolog H6CHR_00889 ENOG4105DZ0 fad dependent oxidoreductase H6CHR_00890 ENOG4105BZU Histidine kinase H6CHR_00891 ENOG4108ZXC Two component transcriptional regulator, luxr family H6CHR_00892 ENOG4108ZXC Two component transcriptional regulator, luxr family H6CHR_00894 ENOG4105E39 Enoyl-CoA hydratase H6CHR_00896 ENOG4105FE9 pseudouridine synthase H6CHR_00897 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H6CHR_00899 ENOG4107R0V Pyruvate dehydrogenase H6CHR_00901 ENOG4105CPP Dehydrogenase, E1 component H6CHR_00902 ENOG4107QSN dihydrolipoamide acetyltransferase H6CHR_00904 ENOG4107QX8 SPFH domain, Band 7 family protein H6CHR_00905 ENOG4105D7N magnesium and cobalt transport protein CorA H6CHR_00908 ENOG4105DJ2 Major Facilitator Superfamily H6CHR_00916 ENOG4105E1J oxidoreductase H6CHR_00918 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H6CHR_00921 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H6CHR_00922 ENOG4105DR4 Methyltransferase H6CHR_00923 ENOG4105CKI cobalamin synthesis protein H6CHR_00926 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) H6CHR_00927 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) H6CHR_00928 ENOG4108V6E Cell division protein mraZ H6CHR_00929 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H6CHR_00930 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H6CHR_00931 ENOG4105CJN penicillin-binding protein H6CHR_00932 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H6CHR_00933 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) H6CHR_00934 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H6CHR_00935 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) H6CHR_00936 ENOG4105CNI cell division protein FtsW H6CHR_00938 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H6CHR_00939 ENOG4105DFU Cell wall formation (By similarity) H6CHR_00940 ENOG4105CPF Cell wall formation (By similarity) H6CHR_00941 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) H6CHR_00942 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H6CHR_00943 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H6CHR_00944 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H6CHR_00946 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H6CHR_00949 ENOG4105K6V RNA polymerase H6CHR_00953 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) H6CHR_00954 ENOG4105KNE Phosphatidate cytidylyltransferase H6CHR_00958 ENOG4105E2X shikimate dehydrogenase H6CHR_00960 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) H6CHR_00961 ENOG4105IPS esterase H6CHR_00962 ENOG4105CNI cell division protein FtsW H6CHR_00963 ENOG4105D1U peptidase U62 modulator of DNA gyrase H6CHR_00964 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H6CHR_00966 ENOG4105DFU Cell wall formation (By similarity) H6CHR_00968 ENOG4107QX9 Thiol disulfide interChange protein H6CHR_00969 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H6CHR_00970 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H6CHR_00971 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) H6CHR_00973 ENOG4107T4Z adenosine kinase H6CHR_00975 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H6CHR_00976 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H6CHR_00978 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H6CHR_00979 ENOG4107TUY Histidine kinase H6CHR_00982 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY H6CHR_00983 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) H6CHR_00984 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H6CHR_00986 ENOG4107WP9 Histidine kinase H6CHR_00987 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H6CHR_00989 ENOG4105ENT Efflux transporter rnd family, mfp subunit H6CHR_00990 ENOG4105BZS acriflavin resistance protein H6CHR_00993 ENOG4107YAK holo-(acyl carrier protein) synthase 2 H6CHR_00998 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) H6CHR_01000 ENOG4105FGE Short-chain dehydrogenase reductase Sdr H6CHR_01004 ENOG4105M0Y H6CHR_01012 ENOG4105CHR reductase H6CHR_01013 ENOG4105CBN LysR family transcriptional regulator H6CHR_01014 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H6CHR_01016 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase H6CHR_01017 ENOG4105BZP glycoside hydrolase 15-related H6CHR_01018 ENOG4108K4C ec 3.1.3.12 H6CHR_01019 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate H6CHR_01020 ENOG4108RXX maleylacetoacetate isomerase H6CHR_01021 ENOG4108302 MgtC SapB transporter H6CHR_01022 ENOG4105E4C Lytic transglycosylase catalytic H6CHR_01023 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H6CHR_01024 ENOG4105ETT transcriptional Regulator, LysR family H6CHR_01027 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H6CHR_01031 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H6CHR_01035 ENOG4105BZJ Electron transfer flavoprotein H6CHR_01036 ENOG4105C10 Electron transfer flavoprotein H6CHR_01044 ENOG4105HEI LysR family (Transcriptional regulator H6CHR_01045 ENOG4108K01 transcriptional regulator H6CHR_01046 ENOG4105D5G Transposase H6CHR_01051 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H6CHR_01057 ENOG4108Q35 Adenylate H6CHR_01060 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_01062 ENOG4108M9J MaoC like domain protein H6CHR_01063 ENOG4105CHR reductase H6CHR_01065 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_01067 ENOG4105C0Z ABC transporter H6CHR_01068 ENOG4108IV0 ABC, transporter H6CHR_01069 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis H6CHR_01073 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F H6CHR_01075 ENOG4105CI0 Citrate lyase H6CHR_01076 ENOG4108WYP Transcriptional regulator H6CHR_01077 ENOG4107T8T UPF0173 metal-dependent hydrolase H6CHR_01082 ENOG4105IKQ hydratase H6CHR_01091 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_01095 ENOG4108NDG TRAP dicarboxylate H6CHR_01097 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_01098 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H6CHR_01103 ENOG4105C94 Transporter H6CHR_01107 ENOG4105EMU Dehydrogenase H6CHR_01108 ENOG4108M0I Transcriptional regulator H6CHR_01110 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H6CHR_01111 ENOG4108HR6 Dehydrogenase H6CHR_01113 ENOG4105C7W Xanthine dehydrogenase H6CHR_01114 ENOG4105CKI cobalamin synthesis protein H6CHR_01117 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H6CHR_01118 ENOG4105C2W permease H6CHR_01119 ENOG4108JQ9 ABC transporter H6CHR_01120 ENOG4105UIB (ABC) transporter H6CHR_01124 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_01132 ENOG4105HEI LysR family (Transcriptional regulator H6CHR_01133 ENOG4108RYK Nad-dependent epimerase dehydratase H6CHR_01135 ENOG4105CH2 amidohydrolase H6CHR_01136 ENOG4108RYR transcriptional regulator AsnC family H6CHR_01142 ENOG4105CJP fad dependent oxidoreductase H6CHR_01143 ENOG4108J59 Extracellular solute-binding protein, family 5 H6CHR_01145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H6CHR_01147 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H6CHR_01148 ENOG4105C26 Dehydrogenase H6CHR_01149 ENOG4108DN8 FAD dependent oxidoreductase H6CHR_01156 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H6CHR_01158 ENOG4105CC0 LysR family Transcriptional regulator H6CHR_01161 ENOG4105CS1 NAD(P)H quinone oxidoreductase H6CHR_01165 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H6CHR_01167 ENOG4105CF7 AraC family transcriptional regulator H6CHR_01168 ENOG4108MJI response regulator H6CHR_01172 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase H6CHR_01181 ENOG4105DS1 cytochrome b561 H6CHR_01182 ENOG4105EQ0 Major Facilitator superfamily H6CHR_01183 ENOG4105HEI LysR family (Transcriptional regulator H6CHR_01186 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) H6CHR_01187 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H6CHR_01190 ENOG4105CG3 alpha amylase, catalytic region H6CHR_01191 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) H6CHR_01192 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H6CHR_01198 ENOG4105BZ1 (ABC) transporter H6CHR_01200 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) H6CHR_01201 ENOG4105CQ0 ABC transporter H6CHR_01203 ENOG4105D7Q type ii secretion system H6CHR_01205 ENOG4107QHF type ii secretion system protein e H6CHR_01206 ENOG4105GVR general secretion pathway protein D H6CHR_01210 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) H6CHR_01215 ENOG4108VAU general secretion pathway protein G H6CHR_01217 ENOG4105C7B Threonine dehydratase H6CHR_01219 ENOG4108UKZ OsmC family H6CHR_01220 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) H6CHR_01221 ENOG4108Z9W Outer membrane porin H6CHR_01223 ENOG4105CH2 amidohydrolase H6CHR_01224 ENOG4108J59 Extracellular solute-binding protein, family 5 H6CHR_01225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H6CHR_01226 ENOG4105C3U ABC transporter H6CHR_01227 ENOG4108JQ7 (ABC) transporter H6CHR_01228 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H6CHR_01231 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H6CHR_01232 ENOG4107QP8 phosphohexose isomerase H6CHR_01234 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H6CHR_01235 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) H6CHR_01236 ENOG4105CHB tonB-dependent Receptor H6CHR_01238 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H6CHR_01240 ENOG4105D1S lipid A biosynthesis H6CHR_01241 ENOG4105D74 hydrolase H6CHR_01242 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) H6CHR_01245 ENOG4105CRE cytochrome C H6CHR_01246 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) H6CHR_01247 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) H6CHR_01248 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H6CHR_01249 ENOG4105XQ6 frataxin-like protein H6CHR_01250 ENOG4108JQC penicillin-binding protein 1A H6CHR_01255 ENOG4105E4G Type IV pilus H6CHR_01256 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H6CHR_01258 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein H6CHR_01265 ENOG4105DHJ ABC, transporter H6CHR_01266 ENOG4105CY3 ABC transporter, permease H6CHR_01267 ENOG4107PE3 Mammalian cell entry related domain protein H6CHR_01271 ENOG4105DA5 (ABC) transporter H6CHR_01272 ENOG4105E3A (ABC) transporter H6CHR_01273 ENOG4105VFK BolA family H6CHR_01274 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H6CHR_01275 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H6CHR_01278 ENOG4105CIH Imidazole acetol-phosphate transaminase H6CHR_01279 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H6CHR_01281 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H6CHR_01283 ENOG4105DSB aldose 1-epimerase H6CHR_01284 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H6CHR_01285 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H6CHR_01286 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase H6CHR_01288 ENOG4107YU2 histidine triad (hIT) protein H6CHR_01289 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H6CHR_01290 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) H6CHR_01291 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H6CHR_01292 ENOG4105C0H protease H6CHR_01293 ENOG4107QNR UPF0135 protein H6CHR_01294 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) H6CHR_01295 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H6CHR_01296 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) H6CHR_01297 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) H6CHR_01298 ENOG4105EIX cytochrome c1 H6CHR_01299 ENOG4107MKT Stringent starvation protein a H6CHR_01300 ENOG4105KB2 stringent starvation protein b H6CHR_01304 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H6CHR_01307 ENOG4105M6F mutator MutT protein H6CHR_01308 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) H6CHR_01311 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H6CHR_01315 ENOG4107QHF type ii secretion system protein e H6CHR_01317 ENOG4108KMV Glycosyl transferase (Group 1 H6CHR_01320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H6CHR_01324 ENOG4105DZ1 carboxypeptidase H6CHR_01326 ENOG4105C6Y Udp-glucose 6-dehydrogenase H6CHR_01328 ENOG4106WTF Glycosyl transferase, family 2 H6CHR_01329 ENOG4105CH7 arginosuccinase H6CHR_01330 ENOG4108HRK Histidine kinase H6CHR_01331 ENOG4108NEV two component transcriptional regulator, LytTR family H6CHR_01332 ENOG4105DSF transport protein H6CHR_01334 ENOG4105CSH Transporter H6CHR_01338 ENOG4105DIA mandelate racemase muconate lactonizing H6CHR_01341 ENOG4105HSS phospholipase C H6CHR_01342 ENOG4105BZ4 penicillin-binding protein H6CHR_01344 ENOG4105KA0 thioesterase Superfamily protein H6CHR_01347 ENOG4105EAH synthase H6CHR_01348 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H6CHR_01349 ENOG4105K46 50S ribosomal protein l27 H6CHR_01350 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H6CHR_01351 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H6CHR_01353 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H6CHR_01354 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H6CHR_01355 ENOG4105E4C Lytic transglycosylase catalytic H6CHR_01356 ENOG4105C37 (CBS) domain H6CHR_01357 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H6CHR_01360 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H6CHR_01361 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H6CHR_01362 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H6CHR_01364 ENOG4105EGS Mechanosensitive ion channel H6CHR_01365 ENOG4107T6V glycerophosphoryl diester phosphodiesterase H6CHR_01366 ENOG4108IJ9 (ABC) transporter H6CHR_01368 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component H6CHR_01370 ENOG4108JQ1 Dehydrogenase H6CHR_01374 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H6CHR_01377 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) H6CHR_01378 ENOG4108IA2 Sodium pantothenate symporter H6CHR_01381 ENOG4105C9M aspartyl-trna synthetase H6CHR_01382 ENOG4108TIT dATP pyrophosphohydrolase H6CHR_01383 ENOG4105X23 Endonuclease Exonuclease phosphatase H6CHR_01384 ENOG4105EUJ GTP cyclohydrolase i H6CHR_01393 ENOG4105BZU Histidine kinase H6CHR_01394 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_01398 ENOG4105D06 uba thif-type nad fad binding protein H6CHR_01399 ENOG4105CN1 protease H6CHR_01400 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H6CHR_01401 ENOG4105WZW rhodanese family H6CHR_01403 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) H6CHR_01404 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H6CHR_01405 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H6CHR_01406 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) H6CHR_01407 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) H6CHR_01408 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H6CHR_01409 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H6CHR_01410 ENOG4108IYU L-aspartate oxidase H6CHR_01415 ENOG4105CHH sulfate transporter H6CHR_01417 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H6CHR_01418 ENOG4108YXG UPF0502 protein H6CHR_01419 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit H6CHR_01420 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H6CHR_01421 ENOG4108JPZ Monovalent cation H antiporter subunit D H6CHR_01423 ENOG4107TDF Formate hydrogenlyase subunit 4 H6CHR_01424 ENOG4108JPZ Monovalent cation H antiporter subunit D H6CHR_01430 ENOG4105C5Q Transcriptional regulator H6CHR_01433 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H6CHR_01435 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) H6CHR_01442 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H6CHR_01443 ENOG4105QAX Iron-sulfur H6CHR_01447 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H6CHR_01448 ENOG4105CV6 ABC transporter, permease H6CHR_01450 ENOG4105C28 cystathionine H6CHR_01454 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H6CHR_01455 ENOG4108RAC Rubrerythrin H6CHR_01458 ENOG4105DRP amino acid AbC transporter H6CHR_01459 ENOG4105EAD ABC transporter H6CHR_01460 ENOG4107RP9 extracellular solute-binding protein, family 3 H6CHR_01463 ENOG4105W5Q DNA repair protein (RadC H6CHR_01464 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase H6CHR_01465 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) H6CHR_01466 ENOG4105C7B Threonine dehydratase H6CHR_01468 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H6CHR_01473 ENOG4105CHR reductase H6CHR_01474 ENOG4105CJW magnesium transporter H6CHR_01475 ENOG4107R1Y fructose-bisphosphate aldolase H6CHR_01476 ENOG4105C7I Dehydrogenase H6CHR_01478 ENOG4105BZU Histidine kinase H6CHR_01480 ENOG4105C31 Tryptophanyl-tRNA synthetase H6CHR_01481 ENOG4108Z4T Peptidase M50 H6CHR_01482 ENOG4107RTD sua5 ycio yrdc ywlc family protein H6CHR_01484 ENOG4105DB7 PHP domain protein H6CHR_01485 ENOG4105CSR polyphosphate kinase 2 H6CHR_01487 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein H6CHR_01488 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_01490 ENOG4105C0Z ABC transporter H6CHR_01491 ENOG4108IV0 ABC, transporter H6CHR_01493 ENOG4105CDA abc transporter atp-binding protein H6CHR_01496 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H6CHR_01498 ENOG4105E5Q amino acid AbC transporter H6CHR_01501 ENOG41079KZ Major Facilitator Superfamily H6CHR_01502 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) H6CHR_01503 ENOG4108Z6B deaminase H6CHR_01504 ENOG4105CC9 acyl-Coa dehydrogenase H6CHR_01506 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_01507 ENOG4108UKI Enoyl-CoA hydratase H6CHR_01509 ENOG4108UKI Enoyl-CoA hydratase H6CHR_01510 ENOG4108WYP Transcriptional regulator H6CHR_01511 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_01512 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_01513 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H6CHR_01514 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_01522 ENOG4105C0Z ABC transporter H6CHR_01523 ENOG4108IV0 ABC, transporter H6CHR_01524 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_01525 ENOG4105CC9 acyl-Coa dehydrogenase H6CHR_01526 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_01533 ENOG4105EYW Ion transport protein H6CHR_01537 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold H6CHR_01544 ENOG4105CHH sulfate transporter H6CHR_01549 ENOG4107UXM Membrane H6CHR_01552 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_01553 ENOG4105D7T ABC transporter H6CHR_01555 ENOG4105C6K Malic enzyme H6CHR_01560 ENOG4105CJ2 (LipO)protein H6CHR_01561 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H6CHR_01563 ENOG4107E2E PKHD-type hydroxylase H6CHR_01564 ENOG4105BZU Histidine kinase H6CHR_01569 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H6CHR_01572 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) H6CHR_01573 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_01582 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease H6CHR_01586 ENOG4105BZU Histidine kinase H6CHR_01587 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) H6CHR_01597 ENOG4105EEX Two component transcriptional regulator (Winged helix family H6CHR_01598 ENOG4105DFH Transport of potassium into the cell (By similarity) H6CHR_01599 ENOG4105DFH Transport of potassium into the cell (By similarity) H6CHR_01601 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_01602 ENOG4105CYC Transferase H6CHR_01603 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr H6CHR_01607 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_01608 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_01618 ENOG4105FDP GntR family transcriptional regulator H6CHR_01620 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H6CHR_01621 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H6CHR_01626 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_01628 ENOG4105C0Z ABC transporter H6CHR_01629 ENOG4108IV0 ABC, transporter H6CHR_01638 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) H6CHR_01645 ENOG4107SFQ iron-sulfur binding H6CHR_01649 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_01650 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ H6CHR_01651 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_01652 ENOG4105EEQ Na H antiporter H6CHR_01654 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H6CHR_01655 ENOG4108WUH Transcriptional regulator, TetR family H6CHR_01657 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_01659 ENOG4107QNJ CoA-transferase subunit B H6CHR_01661 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) H6CHR_01665 ENOG4108JQ7 (ABC) transporter H6CHR_01667 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H6CHR_01674 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H6CHR_01675 ENOG4107YNJ LysR family Transcriptional regulator H6CHR_01676 ENOG4105CMJ mandelate racemase muconate lactonizing H6CHR_01678 ENOG4106FTQ Taurine ABC transporter, periplasmic H6CHR_01680 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_01681 ENOG4105CYM Glutathione S-transferase H6CHR_01683 ENOG4105CSH Transporter H6CHR_01684 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) H6CHR_01685 ENOG4108FUF Transcriptional regulator, IclR family H6CHR_01690 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_01691 ENOG4105CD5 CoA-binding domain protein H6CHR_01695 ENOG4105HEI LysR family (Transcriptional regulator H6CHR_01697 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_01698 ENOG4108EKI Dehydrogenase H6CHR_01716 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_01720 ENOG4108FUF Transcriptional regulator, IclR family H6CHR_01723 ENOG4105DUM transcriptional regulator, lysR family H6CHR_01724 ENOG4105DB1 molybdopterin oxidoreductase H6CHR_01725 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H6CHR_01726 ENOG4108KDI dmso reductase anchor subunit H6CHR_01730 ENOG4105CPQ Dehydrogenase H6CHR_01731 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H6CHR_01734 ENOG4107RZC phospholipase d H6CHR_01739 ENOG4108JU3 Alkyl hydroperoxide reductase H6CHR_01742 ENOG41082BM Transcriptional regulator, arsr family H6CHR_01744 ENOG4107QVM von Willebrand factor, type A H6CHR_01750 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) H6CHR_01751 ENOG4108ZC9 flagellar basal-body rod protein flgc H6CHR_01752 ENOG4105W00 Flagellar hook capping protein H6CHR_01753 ENOG4105BZE flagellar hook protein, FlgE H6CHR_01754 ENOG4108KPB Flagellar basal-body rod protein FlgF H6CHR_01755 ENOG4105CGA flagellar basal-body rod protein FlgG H6CHR_01758 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj H6CHR_01759 ENOG4105C8Q Methyl-accepting chemotaxis H6CHR_01760 ENOG4108V3W Chemotaxis protein, CheW H6CHR_01761 ENOG4105C8Q Methyl-accepting chemotaxis H6CHR_01762 ENOG4105C8Q Methyl-accepting chemotaxis H6CHR_01763 ENOG4105C8Q Methyl-accepting chemotaxis H6CHR_01764 ENOG4105C8Q Methyl-accepting chemotaxis H6CHR_01765 ENOG4105E1Q flagellar hook-associated protein H6CHR_01766 ENOG4105DTJ flagellar hook-associated protein H6CHR_01773 ENOG4108SVW integral membrane protein H6CHR_01775 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H6CHR_01783 ENOG4105E0F Histidine kinase H6CHR_01785 ENOG4105EXG Transcriptional regulator H6CHR_01786 ENOG4105CHR reductase H6CHR_01790 ENOG4105D19 Role in flagellar biosynthesis (By similarity) H6CHR_01791 ENOG4105VS8 Flagellar biosynthetic protein fliq H6CHR_01792 ENOG4105CN7 Flagellar biosynthetic protein FliP H6CHR_01794 ENOG4105DD5 Flagellar motor switch protein H6CHR_01795 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H6CHR_01796 ENOG4107ZI8 flagellar basal body-associated protein flil H6CHR_01797 ENOG4105WF4 Flagellar hook-length control protein H6CHR_01798 ENOG4105GSA Flagellar export protein flij H6CHR_01799 ENOG4108JIR Flagellum-specific ATP synthase H6CHR_01801 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H6CHR_01802 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) H6CHR_01805 ENOG4105DTS flagellar hook-associated H6CHR_01806 ENOG4105MQ3 flagellar protein FliS H6CHR_01811 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region H6CHR_01812 ENOG4107RD7 Flagellar Motor Protein, MotA H6CHR_01813 ENOG4105ER2 Ompa motb domain protein H6CHR_01814 ENOG4105CBS Chea signal transduction histidine kinase H6CHR_01815 ENOG4105D58 Diguanylate phosphodiesterase H6CHR_01816 ENOG4105BZU Histidine kinase H6CHR_01820 ENOG4108VYJ response regulator receiver protein H6CHR_01821 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) H6CHR_01822 ENOG4105D00 flagellar biosynthetic protein flhB H6CHR_01823 ENOG4105D7B Flagellar biosynthesis protein flha H6CHR_01824 ENOG4105FZW flagellar biosynthesis regulator FlhF H6CHR_01826 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H6CHR_01829 ENOG4105TV9 FHA Domain-Containing protein H6CHR_01831 ENOG4108TQ9 Histidine kinase H6CHR_01832 ENOG4108S01 response regulator H6CHR_01837 ENOG4105BZU Histidine kinase H6CHR_01866 ENOG4105EMN RNA polymerase sigma factor H6CHR_01876 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_01878 ENOG4105BZU Histidine kinase H6CHR_01881 ENOG4105C5I Dehydrogenase H6CHR_01882 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H6CHR_01890 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 H6CHR_01891 ENOG4105CD8 aminopeptidase N H6CHR_01892 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) H6CHR_01894 ENOG4105CPC Aldo Keto reductase H6CHR_01895 ENOG4108Z66 YbaK ebsC protein H6CHR_01896 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) H6CHR_01897 ENOG4105M4H endoribonuclease L-psp H6CHR_01899 ENOG4108VPT UPF0234 protein H6CHR_01900 ENOG4105D4A Cell wall formation (By similarity) H6CHR_01901 ENOG4105CDH Citrulline--aspartate ligase H6CHR_01902 ENOG4105NBK UPF0345 protein H6CHR_01904 ENOG4105KUZ arsenate reductase H6CHR_01905 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H6CHR_01908 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H6CHR_01909 ENOG4105C28 cystathionine H6CHR_01910 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H6CHR_01916 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H6CHR_01924 ENOG4108JUA Transcriptional regulator H6CHR_01926 ENOG4105K63 Thioredoxin H6CHR_01930 ENOG4105C3M thioredoxin reductase H6CHR_01931 ENOG4105D0M Protease HtpX homolog H6CHR_01932 ENOG4108ZXC Two component transcriptional regulator, luxr family H6CHR_01933 ENOG4105ECQ AraC Family Transcriptional Regulator H6CHR_01934 ENOG4105K3G Periplasmic Protein H6CHR_01936 ENOG4105VN1 Heat shock protein H6CHR_01938 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H6CHR_01939 ENOG4105BZU Histidine kinase H6CHR_01940 ENOG4105DRR Transcriptional regulator, GntR family H6CHR_01943 ENOG4105CTX dehydratase H6CHR_01946 ENOG41083Z3 extracellular ligand-binding receptor H6CHR_01949 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_01950 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H6CHR_01951 ENOG4105C0Z ABC transporter H6CHR_01952 ENOG4108IV0 ABC, transporter H6CHR_01959 ENOG4105C7W Xanthine dehydrogenase H6CHR_01961 ENOG4105C7N Xanthine uracil vitamin C permease H6CHR_01962 ENOG4108JQ9 ABC transporter H6CHR_01963 ENOG4105UIB (ABC) transporter H6CHR_01967 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H6CHR_01969 ENOG4105BZU Histidine kinase H6CHR_01970 ENOG4107QHF type ii secretion system protein e H6CHR_01971 ENOG4105BZU Histidine kinase H6CHR_01974 ENOG4108TJN glycosyl transferase group 1 H6CHR_01975 ENOG4107QUY Guanine deaminase H6CHR_01976 ENOG4105DHP deoxycytidine triphosphate deaminase H6CHR_01977 ENOG4105CGZ zinc metallopeptidase H6CHR_01978 ENOG4105C1J atp-dependent rna helicase H6CHR_01979 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) H6CHR_01980 ENOG4105EE5 Membrane protein terC H6CHR_01985 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H6CHR_01986 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H6CHR_01987 ENOG41060W2 glyoxylate carboligase H6CHR_01988 ENOG4105CC0 LysR family Transcriptional regulator H6CHR_01999 ENOG4107YCY Transcriptional regulator H6CHR_02000 ENOG4105CK2 sodium dicarboxylate symporter H6CHR_02002 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_02003 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H6CHR_02006 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_02007 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_02011 ENOG4105C3M thioredoxin reductase H6CHR_02018 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme H6CHR_02019 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H6CHR_02022 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_02023 ENOG4105E7U AraC family transcriptional regulator H6CHR_02024 ENOG4105CPQ Dehydrogenase H6CHR_02027 ENOG4105CPQ Dehydrogenase H6CHR_02028 ENOG4105CHR reductase H6CHR_02030 ENOG4105JSC dimethylmenaquinone methyltransferase H6CHR_02033 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H6CHR_02034 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H6CHR_02035 ENOG4105P4J Allophanate hydrolase, subunit 1 H6CHR_02036 ENOG4107R7A Allophanate hydrolase subunit 2 H6CHR_02040 ENOG4108HW4 amino acid AbC transporter H6CHR_02041 ENOG4105DRP amino acid AbC transporter H6CHR_02042 ENOG4105CDA abc transporter atp-binding protein H6CHR_02043 ENOG4106PMH Extracellular solute-binding protein family 3 H6CHR_02046 ENOG4105DTQ mandelate racemase muconate lactonizing H6CHR_02052 ENOG41060NJ transcriptional regulator H6CHR_02055 ENOG4105EN6 Membrane H6CHR_02057 ENOG4105EXW epimerase dehydratase H6CHR_02058 ENOG4108KWP DNA-binding transcriptional regulator GlcC H6CHR_02062 ENOG4105EG2 ABC transporter, permease H6CHR_02064 ENOG4105ETT transcriptional Regulator, LysR family H6CHR_02065 ENOG4105KME endoribonuclease L-psp H6CHR_02069 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H6CHR_02071 ENOG4105F38 ABC transporter, permease H6CHR_02078 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H6CHR_02083 ENOG4105C7W Xanthine dehydrogenase H6CHR_02084 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding H6CHR_02085 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit H6CHR_02086 ENOG4105ECQ AraC Family Transcriptional Regulator H6CHR_02087 ENOG4105F27 Major Facilitator H6CHR_02088 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H6CHR_02091 ENOG4105EJC lysr family transcriptional regulator H6CHR_02093 ENOG4105CV8 reductase H6CHR_02094 ENOG4105C2W permease H6CHR_02100 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein H6CHR_02101 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H6CHR_02104 ENOG4107YCY Transcriptional regulator H6CHR_02112 ENOG4105CJ1 ABC, transporter H6CHR_02113 ENOG4107QWP ABC-2 type transporter H6CHR_02114 ENOG4107QWP ABC-2 type transporter H6CHR_02125 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein H6CHR_02130 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_02131 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H6CHR_02132 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase H6CHR_02156 ENOG4105CDV Ompa motb domain protein H6CHR_02166 ENOG4105EMN RNA polymerase sigma factor H6CHR_02167 ENOG4108K2P TRANSCRIPTIONal H6CHR_02168 ENOG4105C5I Dehydrogenase H6CHR_02171 ENOG4105E39 Enoyl-CoA hydratase H6CHR_02174 ENOG4105C59 p-type ATPase H6CHR_02176 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding H6CHR_02179 ENOG4107RT3 EamA-like transporter family H6CHR_02182 ENOG4107QKV phosphomannomutase H6CHR_02183 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H6CHR_02190 ENOG4108KE4 O-methyltransferase H6CHR_02192 ENOG4105ENT Efflux transporter rnd family, mfp subunit H6CHR_02193 ENOG4105YA8 Transcriptional regulator H6CHR_02194 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H6CHR_02197 ENOG4105CFH Aspartokinase H6CHR_02198 ENOG4105CPC Aldo Keto reductase H6CHR_02200 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) H6CHR_02205 ENOG4105C01 Dihydroxy-acid dehydratase H6CHR_02206 ENOG4108UHU Aldolase H6CHR_02208 ENOG4108UYE Lactoylglutathione lyase H6CHR_02212 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_02213 ENOG4105EA8 2-Nitropropane dioxygenase H6CHR_02214 ENOG4107GJV short-chain dehydrogenase reductase H6CHR_02216 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_02217 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H6CHR_02218 ENOG4105CHR reductase H6CHR_02221 ENOG4105DIQ Transcriptional regulator H6CHR_02222 ENOG4107TTA Xylose isomerase domain protein TIM barrel H6CHR_02226 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_02227 ENOG4105D7K pfkb domain protein H6CHR_02234 ENOG4105CHR reductase H6CHR_02237 ENOG4108RTU Aldolase H6CHR_02239 ENOG4105C01 Dihydroxy-acid dehydratase H6CHR_02240 ENOG4107EJG GntR family transcriptional regulator H6CHR_02242 ENOG4105D56 permease protein H6CHR_02245 ENOG4106IPI cyclase, family H6CHR_02249 ENOG4107EPV Aminotransferase class V H6CHR_02251 ENOG4105C1J atp-dependent rna helicase H6CHR_02252 ENOG4105C5H ABC transporter H6CHR_02258 ENOG4108JJA ABC, transporter H6CHR_02260 ENOG4105CHR reductase H6CHR_02261 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_02262 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_02264 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H6CHR_02265 ENOG4105E39 Enoyl-CoA hydratase H6CHR_02267 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_02268 ENOG4107QX3 carboxylase H6CHR_02273 ENOG4108KB1 transcriptional regulator, arac family H6CHR_02275 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_02277 ENOG4107QX3 carboxylase H6CHR_02278 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H6CHR_02280 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_02282 ENOG4105C0Z ABC transporter H6CHR_02283 ENOG4108IV0 ABC, transporter H6CHR_02286 ENOG4107QX3 carboxylase H6CHR_02288 ENOG4105KXX peptidase s58 dmpa H6CHR_02290 ENOG4105W1Y Transcriptional regulator H6CHR_02294 ENOG4108Z9K Osmotically inducible protein H6CHR_02295 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_02298 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase H6CHR_02299 ENOG4105CEP NADH dehydrogenase H6CHR_02300 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process H6CHR_02301 ENOG41067HS methyltransferase H6CHR_02304 ENOG41081QV Universal stress protein H6CHR_02306 ENOG4105BZU Histidine kinase H6CHR_02313 ENOG4105D3G Pseudouridine synthase H6CHR_02318 ENOG4105CKW Inner membrane protein yedI H6CHR_02319 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) H6CHR_02321 ENOG4105F4K antigen 43 H6CHR_02326 ENOG4106CJB Phospholipase Carboxylesterase H6CHR_02327 ENOG4105D9M gamma-glutamylcysteine synthetase H6CHR_02328 ENOG4107QWB Ornithine cyclodeaminase H6CHR_02329 ENOG4108UYB regulatoR H6CHR_02330 ENOG4105F0I Aminotransferase H6CHR_02332 ENOG4108VAC response regulator H6CHR_02333 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) H6CHR_02338 ENOG4107XZC Restriction modification system DNA (Specificity H6CHR_02341 ENOG4105CX6 glutaminyL-tRNA synthetase H6CHR_02343 ENOG4108VAC response regulator H6CHR_02344 ENOG4108HRK Histidine kinase H6CHR_02347 ENOG4105ENT Efflux transporter rnd family, mfp subunit H6CHR_02348 ENOG4105BZS acriflavin resistance protein H6CHR_02350 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H6CHR_02356 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) H6CHR_02361 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) H6CHR_02363 ENOG41061MV Arylsulfatase H6CHR_02364 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_02366 ENOG4108VHT MarR family transcriptional regulator H6CHR_02368 ENOG4105DDW LysR family Transcriptional regulator H6CHR_02371 ENOG4105ECY inositol monophosphatase H6CHR_02373 ENOG4105D7W serine acetyltransferase H6CHR_02374 ENOG4108RIR Molybdenum cofactor biosynthesis protein H6CHR_02375 ENOG4105N42 UPF0307 protein H6CHR_02376 ENOG4105CMS peptidase U62, modulator of DNA gyrase H6CHR_02378 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H6CHR_02379 ENOG4105KTH gatB Yqey H6CHR_02380 ENOG4105VCC 30S ribosomal protein S21 H6CHR_02381 ENOG4105CBX hi0933 family H6CHR_02383 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H6CHR_02384 ENOG4108MTB glycosyl transferase family H6CHR_02387 ENOG4108IFG nitrite reductase, (NAD(P)H) H6CHR_02388 ENOG4105D9P serine threonine protein kinase H6CHR_02391 ENOG4105D7T ABC transporter H6CHR_02393 ENOG4105I5W Transporter H6CHR_02395 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H6CHR_02398 ENOG4105ES9 amino acid H6CHR_02399 ENOG4105CHM Aminotransferase H6CHR_02400 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H6CHR_02401 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H6CHR_02403 ENOG4105CP7 Triose-phosphate isomerase H6CHR_02404 ENOG4107EJC Preprotein translocase subunit SecG H6CHR_02406 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H6CHR_02407 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H6CHR_02408 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H6CHR_02409 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H6CHR_02411 ENOG4107QIZ NADH dehydrogenase H6CHR_02412 ENOG4108IEH NADH dehydrogenase subunit g H6CHR_02413 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H6CHR_02414 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H6CHR_02415 ENOG4105DF2 NADH dehydrogenase subunit j H6CHR_02416 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H6CHR_02418 ENOG4105C8S subunit m H6CHR_02419 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H6CHR_02421 ENOG4108YZ4 nudix hydrolase H6CHR_02425 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_02427 ENOG4105CFM UPF0317 protein H6CHR_02432 ENOG4105C26 Dehydrogenase H6CHR_02433 ENOG4105C7K acetolactate synthase H6CHR_02435 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_02436 ENOG4105CM2 brancheD-chain amino acid aminotransferase H6CHR_02438 ENOG4105BZ1 (ABC) transporter H6CHR_02439 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes H6CHR_02441 ENOG4105CW7 secretion protein, HlyD family H6CHR_02442 ENOG4105C0R drug resistance transporter emrb qaca subfamily H6CHR_02443 ENOG4105C0Z ABC transporter H6CHR_02444 ENOG4108IV0 ABC, transporter H6CHR_02447 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_02450 ENOG4105VFU Rna-binding protein H6CHR_02452 ENOG4105ETT transcriptional Regulator, LysR family H6CHR_02453 ENOG4105DRR Transcriptional regulator, GntR family H6CHR_02456 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) H6CHR_02459 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H6CHR_02461 ENOG4105CSH Transporter H6CHR_02463 ENOG4108SHN Glycosyl transferase, family 2 H6CHR_02471 ENOG4105GRZ Ycii-related protein H6CHR_02472 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H6CHR_02475 ENOG4105JXH GntR family transcriptional regulator H6CHR_02478 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_02479 ENOG4105EXG Transcriptional regulator H6CHR_02480 ENOG4105CG3 alpha amylase, catalytic region H6CHR_02481 ENOG4107QK4 glycoside hydrolase, family 3 domain protein H6CHR_02484 ENOG4105CQ0 ABC transporter H6CHR_02488 ENOG4105CHR reductase H6CHR_02489 ENOG4105C5Q Transcriptional regulator H6CHR_02490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H6CHR_02491 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H6CHR_02493 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate H6CHR_02495 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_02496 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_02497 ENOG4105ETE Transcriptional regulator (LacI family H6CHR_02499 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H6CHR_02500 ENOG4105DQR SNARE associated Golgi H6CHR_02503 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H6CHR_02504 ENOG4105K8N protein family UPF0079, ATPase H6CHR_02505 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H6CHR_02509 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H6CHR_02512 ENOG4105ED9 Protein of unknown function (DUF455) H6CHR_02513 ENOG4108Z0R Transferase H6CHR_02514 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) H6CHR_02517 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H6CHR_02518 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H6CHR_02519 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H6CHR_02520 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H6CHR_02521 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H6CHR_02523 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H6CHR_02525 ENOG4108YZY peptidylprolyl cis-trans isomerase H6CHR_02526 ENOG4105EZE Cupin 4 family protein H6CHR_02529 ENOG4105Q2H domain protein H6CHR_02530 ENOG4105GJM (LipO)protein H6CHR_02531 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H6CHR_02535 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H6CHR_02537 ENOG4105EMN RNA polymerase sigma factor H6CHR_02538 ENOG4105E4C Lytic transglycosylase catalytic H6CHR_02539 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H6CHR_02542 ENOG4105C26 Dehydrogenase H6CHR_02547 ENOG4105C5Q Transcriptional regulator H6CHR_02548 ENOG4107QPD alcohol dehydrogenase H6CHR_02550 ENOG4108IV0 ABC, transporter H6CHR_02551 ENOG4105C0Z ABC transporter H6CHR_02558 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H6CHR_02560 ENOG4105E5Q amino acid AbC transporter H6CHR_02561 ENOG4105E5Q amino acid AbC transporter H6CHR_02562 ENOG4105EAB amino acid AbC transporter H6CHR_02563 ENOG4105CDA abc transporter atp-binding protein H6CHR_02565 ENOG4105D7K pfkb domain protein H6CHR_02567 ENOG4108M60 Transcriptional regulator H6CHR_02570 ENOG4107RTG Major Facilitator superfamily H6CHR_02572 ENOG4108UYU AsnC family transcriptional regulator H6CHR_02577 ENOG4108EC8 DNA internalization-related competence protein ComEC H6CHR_02582 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H6CHR_02583 ENOG4105E98 transcriptional regulator DeoR family H6CHR_02584 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H6CHR_02585 ENOG4108IJ9 (ABC) transporter H6CHR_02586 ENOG4108IJ9 (ABC) transporter H6CHR_02589 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component H6CHR_02593 ENOG4105CVE Lytic murein transglycosylase H6CHR_02594 ENOG4105F8C transglutaminase domain-containing protein H6CHR_02596 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H6CHR_02597 ENOG4105DGU Histone deacetylase H6CHR_02598 ENOG4105EGS Mechanosensitive ion channel H6CHR_02599 ENOG4105BZJ Electron transfer flavoprotein H6CHR_02600 ENOG4105C10 Electron transfer flavoprotein H6CHR_02601 ENOG4105CSU acyl-Coa dehydrogenase H6CHR_02605 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H6CHR_02606 ENOG4105C4M (Ubiquinol oxidase) subunit I H6CHR_02608 ENOG4105BZU Histidine kinase H6CHR_02612 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H6CHR_02613 ENOG4105C6X Major Facilitator H6CHR_02614 ENOG4105CSH Transporter H6CHR_02616 ENOG4107HP6 Transcriptional regulator H6CHR_02617 ENOG4105E2X shikimate dehydrogenase H6CHR_02619 ENOG4105E2X shikimate dehydrogenase H6CHR_02620 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase H6CHR_02627 ENOG4105EGI Transcriptional regulator H6CHR_02628 ENOG4105CBP Major Facilitator H6CHR_02632 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H6CHR_02634 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor H6CHR_02635 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) H6CHR_02636 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H6CHR_02639 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_02641 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_02642 ENOG4105EXW epimerase dehydratase H6CHR_02644 ENOG4105C0Z ABC transporter H6CHR_02645 ENOG4108IV0 ABC, transporter H6CHR_02646 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_02647 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H6CHR_02649 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H6CHR_02652 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase H6CHR_02653 ENOG4105CHR reductase H6CHR_02656 ENOG4105DHQ Histidine kinase H6CHR_02657 ENOG4105XJC Two component transcriptional regulator (Winged helix family H6CHR_02659 ENOG4105DIJ Phosphoethanolamine transferase H6CHR_02662 ENOG4107FQ9 ethanolamine ammonia-lyase H6CHR_02663 ENOG4105CPD ethanolamine ammonia-lyase H6CHR_02664 ENOG4108V1T peptidylprolyl cis-trans isomerase H6CHR_02666 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H6CHR_02668 ENOG4105CF1 Alkylated DNA repair protein H6CHR_02682 ENOG4105C26 Dehydrogenase H6CHR_02684 ENOG4105E39 Enoyl-CoA hydratase H6CHR_02685 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H6CHR_02686 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H6CHR_02695 ENOG41061ZR Transcriptional regulator H6CHR_02697 ENOG4107RZC phospholipase d H6CHR_02698 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase H6CHR_02699 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H6CHR_02701 ENOG4105BZ1 (ABC) transporter H6CHR_02702 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H6CHR_02707 ENOG4105C0B DNA polymerase III (alpha subunit) H6CHR_02711 ENOG4108W9H Tetr family transcriptional regulator H6CHR_02712 ENOG4105C42 Type I secretion membrane fusion protein (HlyD H6CHR_02713 ENOG4108JJA ABC, transporter H6CHR_02721 ENOG4105BZ9 Cytochrome C oxidase, subunit I H6CHR_02722 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) H6CHR_02725 ENOG4105NXH GreA GreB family elongation factor H6CHR_02728 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_02729 ENOG4108ERU trap dicarboxylate transporter subunit DctP H6CHR_02732 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_02733 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr H6CHR_02736 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H6CHR_02737 ENOG4105CMV Succinyl-CoA synthetase subunit beta H6CHR_02738 ENOG4105E39 Enoyl-CoA hydratase H6CHR_02742 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H6CHR_02743 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_02752 ENOG4105CHR reductase H6CHR_02755 ENOG4105C10 Electron transfer flavoprotein H6CHR_02758 ENOG4105D82 Glutamate dehydrogenase H6CHR_02759 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H6CHR_02761 ENOG4105MWK D-amino acid dehydrogenase, small subunit H6CHR_02762 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) H6CHR_02768 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H6CHR_02769 ENOG4107HP6 Transcriptional regulator H6CHR_02771 ENOG4105C7K acetolactate synthase H6CHR_02772 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) H6CHR_02776 ENOG4105MSY salicylate hydroxylase H6CHR_02780 ENOG4108Z9W Outer membrane porin H6CHR_02783 ENOG4105CSH Transporter H6CHR_02787 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_02788 ENOG4106YT9 Enoyl-CoA hydratase H6CHR_02789 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_02790 ENOG4105E39 Enoyl-CoA hydratase H6CHR_02791 ENOG4108X0B nad(p)h dehydrogenase (quinone) H6CHR_02792 ENOG4105MP9 class II Aldolase H6CHR_02793 ENOG4105CQZ Histidine kinase H6CHR_02794 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H6CHR_02796 ENOG4105CD5 CoA-binding domain protein H6CHR_02797 ENOG4105CD5 CoA-binding domain protein H6CHR_02798 ENOG4108IRC dna polymerase iii H6CHR_02799 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H6CHR_02803 ENOG4107QN1 sodium solute H6CHR_02804 ENOG41062QD Membrane H6CHR_02808 ENOG4105D4P Coproporphyrinogen iii oxidase H6CHR_02810 ENOG4105BZU Histidine kinase H6CHR_02814 ENOG4105CRU nitrate reductase, alpha subunit H6CHR_02815 ENOG4108IUE nitrate reductase beta subunit H6CHR_02816 ENOG4105R3A Nitrate reductase H6CHR_02817 ENOG4105D0D Nitrate reductase 2, gamma subunit H6CHR_02818 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H6CHR_02823 ENOG4105DZG Dehydrogenase H6CHR_02824 ENOG4105VMH Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria (By similarity) H6CHR_02826 ENOG4105DZG Dehydrogenase H6CHR_02832 ENOG4105C26 Dehydrogenase H6CHR_02838 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i H6CHR_02845 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H6CHR_02848 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H6CHR_02850 ENOG41080TK Universal stress protein H6CHR_02855 ENOG4105C0H protease H6CHR_02857 ENOG4105F8V Hydrolase, tatD family H6CHR_02859 ENOG4107QRG dna polymerase iii H6CHR_02860 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) H6CHR_02861 ENOG4105HHA aminodeoxychorismate lyase H6CHR_02862 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) H6CHR_02863 ENOG4105VCD cytoplasmic protein H6CHR_02864 ENOG4105D22 carbon starvation protein H6CHR_02870 ENOG4105C0A alcohol dehydrogenase H6CHR_02871 ENOG4105ETT transcriptional Regulator, LysR family H6CHR_02875 ENOG4105BZM domain protein H6CHR_02876 ENOG4105EJC lysr family transcriptional regulator H6CHR_02879 ENOG4105DJB Major Facilitator Superfamily H6CHR_02881 ENOG4107QJQ Mate efflux family protein H6CHR_02893 ENOG4105C0R drug resistance transporter emrb qaca subfamily H6CHR_02894 ENOG4105C2C drug resistance transporter, Bcr CflA H6CHR_02897 ENOG4105DY2 Paraquat-inducible protein b H6CHR_02898 ENOG4105F1S paraquat-inducible protein a H6CHR_02899 ENOG4105H2K paraquat-inducible protein a H6CHR_02900 ENOG4105HEI LysR family (Transcriptional regulator H6CHR_02901 ENOG4105F27 Major Facilitator H6CHR_02902 ENOG4105CPC Aldo Keto reductase H6CHR_02903 ENOG4105XJC Two component transcriptional regulator (Winged helix family H6CHR_02904 ENOG4105DHQ Histidine kinase H6CHR_02906 ENOG4105C2W permease H6CHR_02907 ENOG4105KCV RNA signal recognition particle 4.5S RNA H6CHR_02911 ENOG4105CSU acyl-Coa dehydrogenase H6CHR_02912 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H6CHR_02914 ENOG4105CHR reductase H6CHR_02916 ENOG4105CSU acyl-Coa dehydrogenase H6CHR_02917 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_02918 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H6CHR_02919 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H6CHR_02920 ENOG4108IV0 ABC, transporter H6CHR_02921 ENOG4105C0Z ABC transporter H6CHR_02923 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_02925 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_02926 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H6CHR_02927 ENOG4105CNG UPF0061 protein H6CHR_02928 ENOG4105E0X reductase H6CHR_02929 ENOG4107835 probably involved in intracellular septation (By similarity) H6CHR_02931 ENOG4107TF3 peptidylprolyl cis-trans isomerase H6CHR_02932 ENOG4108ETH Formylglycinamide ribotide synthetase H6CHR_02933 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H6CHR_02934 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) H6CHR_02935 ENOG4105MGM doxx family H6CHR_02936 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H6CHR_02938 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H6CHR_02940 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) H6CHR_02953 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) H6CHR_02954 ENOG4108IJ6 ABC transporter H6CHR_02955 ENOG4105ECW sulfate abc transporter H6CHR_02956 ENOG4108I5D sulfate abc transporter H6CHR_02957 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H6CHR_02959 ENOG4105JQN Transcriptional regulator H6CHR_02960 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H6CHR_02962 ENOG4105D7W serine acetyltransferase H6CHR_02963 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H6CHR_02964 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) H6CHR_02965 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) H6CHR_02968 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) H6CHR_02970 ENOG4108UT2 hemolysin iii H6CHR_02975 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) H6CHR_02977 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) H6CHR_02978 ENOG4108Z4U Ferredoxin H6CHR_02979 ENOG4105CAY ferredoxin--nadp reductase H6CHR_02980 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H6CHR_02982 ENOG4105W2Z cytochrome C, class I H6CHR_02984 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H6CHR_02985 ENOG4108TEB UPF0114 protein H6CHR_02988 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H6CHR_02995 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H6CHR_02996 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H6CHR_02997 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H6CHR_02998 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation H6CHR_03001 ENOG4105ENT Efflux transporter rnd family, mfp subunit H6CHR_03005 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H6CHR_03012 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant H6CHR_03013 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) H6CHR_03018 ENOG4108IV0 ABC, transporter H6CHR_03019 ENOG4108IUZ ABC transporter H6CHR_03021 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H6CHR_03033 ENOG4105CC0 LysR family Transcriptional regulator H6CHR_03035 ENOG4105E39 Enoyl-CoA hydratase H6CHR_03037 ENOG4105CC9 acyl-Coa dehydrogenase H6CHR_03039 ENOG4105CHR reductase H6CHR_03045 ENOG4105EG6 Saccharopine dehydrogenase H6CHR_03046 ENOG4105EAH synthase H6CHR_03048 ENOG4105CVN desaturase H6CHR_03049 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation H6CHR_03050 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H6CHR_03056 ENOG4105DHQ Histidine kinase H6CHR_03057 ENOG4105VEJ Heat shock protein H6CHR_03058 ENOG4105CSR polyphosphate kinase 2 H6CHR_03077 ENOG4105DFP Integrase H6CHR_03079 ENOG4105CFH Aspartokinase H6CHR_03080 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H6CHR_03081 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H6CHR_03083 ENOG4105C8N cysteinyl-tRNA synthetase H6CHR_03087 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) H6CHR_03088 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) H6CHR_03091 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division H6CHR_03092 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H6CHR_03093 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) H6CHR_03099 ENOG4106855 Competence protein H6CHR_03100 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H6CHR_03102 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H6CHR_03103 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H6CHR_03104 ENOG4107YIM Involved in the transcription termination process (By similarity) H6CHR_03105 ENOG4105CHM Aminotransferase H6CHR_03106 ENOG4107YD3 Thioesterase H6CHR_03107 ENOG4105E02 MotA TolQ exbB proton channel H6CHR_03108 ENOG4108ZZF transport protein (ExbD) H6CHR_03111 ENOG4105C0B DNA polymerase III (alpha subunit) H6CHR_03112 ENOG4105C72 UPF0176 protein H6CHR_03113 ENOG4105EUB pirin domain protein H6CHR_03115 ENOG4108VBZ doxx family H6CHR_03119 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) H6CHR_03120 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H6CHR_03123 ENOG4105CKT filamentous hemagglutinin H6CHR_03124 ENOG4105D5K Hemolysin activator protein H6CHR_03127 ENOG4105FDF Could be involved in DNA repair (By similarity) H6CHR_03129 ENOG4105C8Q Methyl-accepting chemotaxis H6CHR_03133 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H6CHR_03134 ENOG4108Z6B deaminase H6CHR_03139 ENOG4108ZXC Two component transcriptional regulator, luxr family H6CHR_03140 ENOG4105BZU Histidine kinase H6CHR_03141 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_03144 ENOG4105CSH Transporter H6CHR_03145 ENOG4105E2S oxidase) subunit II H6CHR_03146 ENOG4105BZ9 Cytochrome C oxidase, subunit I H6CHR_03147 ENOG4105CCU oxidase (Subunit III) H6CHR_03148 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) H6CHR_03150 ENOG4105TX3 Histidine kinase H6CHR_03151 ENOG4108UYB regulatoR H6CHR_03152 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) H6CHR_03154 ENOG4105C4Y ABC transporter H6CHR_03155 ENOG4107RCV ABC transporter, permease H6CHR_03157 ENOG4107SM8 Adenylate Guanylate cyclase H6CHR_03158 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H6CHR_03159 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H6CHR_03162 ENOG4108Z1B Cyclase dehydrase H6CHR_03163 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H6CHR_03170 ENOG4105CI3 gtp-binding protein typa H6CHR_03171 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H6CHR_03172 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H6CHR_03174 ENOG4105CHV Transcription elongation factor NusA H6CHR_03175 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) H6CHR_03176 ENOG4105CBP Major Facilitator H6CHR_03177 ENOG4108JQ5 ABC transporter H6CHR_03178 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component H6CHR_03179 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component H6CHR_03181 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H6CHR_03185 ENOG4105CXN decarboxylase H6CHR_03195 ENOG4105DQE DNA ligase H6CHR_03214 ENOG4105DFP Integrase H6CHR_03216 ENOG4105CP9 extracellular ligand-binding receptor H6CHR_03219 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H6CHR_03223 ENOG4107R11 Transcriptional regulator H6CHR_03224 ENOG4105CHM Aminotransferase H6CHR_03226 ENOG4105CQ7 ATP-dependent helicase H6CHR_03227 ENOG4108EKC n-acetylglutamate synthase H6CHR_03228 ENOG4105CHM Aminotransferase H6CHR_03229 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) H6CHR_03230 ENOG4105CZX twitching motility protein H6CHR_03231 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H6CHR_03232 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) H6CHR_03233 ENOG4105C5H ABC transporter H6CHR_03256 ENOG4105CUZ uba thif-type nad fad binding protein H6CHR_03258 ENOG4105KCK Peptidoglycan-associated lipoprotein H6CHR_03259 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) H6CHR_03260 ENOG4105BZ1 (ABC) transporter H6CHR_03261 ENOG4105C03 ribonuclease H6CHR_03262 ENOG4108Z03 MAF-like protein H6CHR_03263 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) H6CHR_03264 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) H6CHR_03265 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) H6CHR_03266 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) H6CHR_03267 ENOG4105C12 Phosphoribosylglycinamide synthetase H6CHR_03268 ENOG4105CDY transcriptional regulatory protein H6CHR_03277 ENOG4108M24 von Willebrand factor, type A H6CHR_03280 ENOG4105C2D reductase H6CHR_03287 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H6CHR_03290 ENOG4105D7A ATP-binding protein H6CHR_03292 ENOG4105NCT RNA Polymerase H6CHR_03294 ENOG4105E18 UPF0276 protein H6CHR_03299 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H6CHR_03300 ENOG4107TFB basic membrane H6CHR_03301 ENOG4108JQ9 ABC transporter H6CHR_03302 ENOG4105UIB (ABC) transporter H6CHR_03304 ENOG4105DZC cytosine deaminase H6CHR_03305 ENOG4105CJB Exodeoxyribonuclease I H6CHR_03306 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H6CHR_03307 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H6CHR_03308 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) H6CHR_03312 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H6CHR_03313 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H6CHR_03315 ENOG4108ZZF transport protein (ExbD) H6CHR_03316 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) H6CHR_03317 ENOG4105W49 UPF0434 protein H6CHR_03318 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) H6CHR_03319 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H6CHR_03322 ENOG4105HDK L-asparaginase H6CHR_03323 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) H6CHR_03325 ENOG4108JQ1 Dehydrogenase H6CHR_03326 ENOG4105F27 Major Facilitator H6CHR_03328 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H6CHR_03329 ENOG4108UKI Enoyl-CoA hydratase H6CHR_03333 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H6CHR_03335 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H6CHR_03336 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) H6CHR_03340 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H6CHR_03342 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H6CHR_03345 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H6CHR_03346 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H6CHR_03347 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H6CHR_03348 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H6CHR_03349 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H6CHR_03351 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H6CHR_03352 ENOG4105DZP Membrane-associated zinc metalloprotease H6CHR_03353 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H6CHR_03354 ENOG4105KNE Phosphatidate cytidylyltransferase H6CHR_03355 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H6CHR_03356 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H6CHR_03357 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H6CHR_03358 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) H6CHR_03359 ENOG4105CE9 30S ribosomal protein S2 H6CHR_03362 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H6CHR_03363 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H6CHR_03364 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H6CHR_03366 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) H6CHR_03367 ENOG4108NVM synthesis repressor PhaR H6CHR_03370 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H6CHR_03371 ENOG4105DTD Dehydrogenase H6CHR_03375 ENOG4105E0F Histidine kinase H6CHR_03376 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) H6CHR_03377 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) H6CHR_03378 ENOG4108JA2 transcriptioN-repair coupling factor H6CHR_03379 ENOG4105EAC phosphoserine phosphatase H6CHR_03384 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H6CHR_03385 ENOG4105CSM endonuclease III H6CHR_03386 ENOG4105DS1 cytochrome b561 H6CHR_03388 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) H6CHR_03389 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) H6CHR_03390 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H6CHR_03393 ENOG4105C1P efflux transporter, rnd family, mfp subunit H6CHR_03398 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase H6CHR_03399 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) H6CHR_03400 ENOG4105S6R Iron-hydroxamate transporter permease subunit H6CHR_03401 ENOG4108HUF Transporter H6CHR_03402 ENOG4108YZT Adenosylcobinamide kinase H6CHR_03403 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) H6CHR_03407 ENOG4105HF0 Membrane H6CHR_03409 ENOG4105ECQ AraC Family Transcriptional Regulator H6CHR_03410 ENOG4105ES4 Nitrilase H6CHR_03411 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_03415 ENOG4105DRR Transcriptional regulator, GntR family H6CHR_03416 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) H6CHR_03417 ENOG4106NZI LysR family Transcriptional regulator H6CHR_03418 ENOG4105C01 Dihydroxy-acid dehydratase H6CHR_03423 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) H6CHR_03424 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H6CHR_03426 ENOG4105VUH addiction module killer protein H6CHR_03427 ENOG4105YES addiction module antidote protein H6CHR_03429 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H6CHR_03431 ENOG4105DQE DNA ligase H6CHR_03440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H6CHR_03441 ENOG4105DEI Mannitol dehydrogenase H6CHR_03442 ENOG4105CHR reductase H6CHR_03443 ENOG4105EQD regulatoR H6CHR_03444 ENOG4105CMG Carbohydrate kinase H6CHR_03447 ENOG4105C0H protease H6CHR_03448 ENOG4105DHQ Histidine kinase H6CHR_03449 ENOG4105XJC Two component transcriptional regulator (Winged helix family H6CHR_03450 ENOG4107HP6 Transcriptional regulator H6CHR_03451 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase H6CHR_03453 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) H6CHR_03454 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate H6CHR_03455 ENOG41069M3 Transcriptional regulator H6CHR_03456 ENOG41061WM D-Alanyl-D-Alanine H6CHR_03457 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H6CHR_03458 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H6CHR_03459 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase H6CHR_03460 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H6CHR_03461 ENOG4108ZP8 Acetolactate synthase small subunit H6CHR_03462 ENOG4105C7K acetolactate synthase H6CHR_03467 ENOG41080IJ Diacylglycerol kinase H6CHR_03468 ENOG4108URH decarboxylase H6CHR_03469 ENOG4108YZA Nitrogen regulatory protein pii H6CHR_03470 ENOG4105FDR Membrane H6CHR_03472 ENOG4105F0N pyrophosphate phospho-hydrolase H6CHR_03477 ENOG4107RZC phospholipase d H6CHR_03479 ENOG4105C26 Dehydrogenase H6CHR_03481 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic H6CHR_03483 ENOG41080TK Universal stress protein H6CHR_03484 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class H6CHR_03487 ENOG4105CHR reductase H6CHR_03493 ENOG4105CF7 AraC family transcriptional regulator H6CHR_03494 ENOG4105CHR reductase H6CHR_03496 ENOG4105DBV ornithine carbamoyltransferase H6CHR_03500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H6CHR_03505 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) H6CHR_03506 ENOG4105CY0 Metallo-Beta-Lactamase H6CHR_03512 ENOG41080TK Universal stress protein H6CHR_03513 ENOG4107Y70 Heat shock protein H6CHR_03521 ENOG4105C0H protease H6CHR_03526 ENOG4105ERH Fumarylacetoacetate hydrolase H6CHR_03527 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase H6CHR_03528 ENOG4107XBN GntR Family Transcriptional Regulator H6CHR_03529 ENOG4108YYH Nadph-dependent fmn reductase H6CHR_03530 ENOG4105CV1 Transketolase (EC 2.2.1.1) H6CHR_03531 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) H6CHR_03532 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 H6CHR_03535 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 H6CHR_03536 ENOG4106F1P AAA ATPase, central domain protein H6CHR_03537 ENOG4108VFZ ribulose bisphosphate carboxylase, small H6CHR_03538 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate H6CHR_03539 ENOG4105DUM transcriptional regulator, lysR family H6CHR_03541 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_03545 ENOG4105CJ1 ABC, transporter H6CHR_03546 ENOG4105DZG Dehydrogenase H6CHR_03547 ENOG4105WJN methanol dehydrogenase-like protein, cytochrome cL (XoxG) H6CHR_03551 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H6CHR_03558 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E H6CHR_03559 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d H6CHR_03560 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) H6CHR_03561 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) H6CHR_03564 ENOG4105BZU Histidine kinase H6CHR_03565 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_03570 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) H6CHR_03571 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A H6CHR_03573 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H6CHR_03581 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family H6CHR_03583 ENOG4108P4C Formaldehyde-activating enzyme H6CHR_03585 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) H6CHR_03586 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) H6CHR_03588 ENOG4108M6X Dehydrogenase H6CHR_03591 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H6CHR_03592 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H6CHR_03593 ENOG4105CVM Molybdenum cofactor synthesis domain protein H6CHR_03595 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H6CHR_03597 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H6CHR_03598 ENOG4105E9H Lytic Murein transglycosylase H6CHR_03599 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H6CHR_03601 ENOG4105D2X ABC transporter substrate-binding protein H6CHR_03603 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H6CHR_03604 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H6CHR_03605 ENOG4107QMP dna polymerase iii subunits gamma and tau H6CHR_03610 ENOG4105CAU Arsenical resistance protein, ArsH H6CHR_03611 ENOG4105D6J arsenicaL-resistance protein H6CHR_03612 ENOG41085FC arsR family transcriptional regulator H6CHR_03615 ENOG41080HT Transcriptional regulator, arsr family H6CHR_03621 ENOG4107TPS domain protein H6CHR_03626 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H6CHR_03627 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation H6CHR_03628 ENOG4105K63 Thioredoxin H6CHR_03629 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H6CHR_03630 ENOG4105D9R oxidoreductase H6CHR_03631 ENOG4105NRA 50s ribosomal protein l31 type b H6CHR_03633 ENOG4107QI1 Mate efflux family protein H6CHR_03634 ENOG4105BZU Histidine kinase H6CHR_03635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H6CHR_03637 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H6CHR_03638 ENOG4105E2Z phosphate ABC transporter (Permease H6CHR_03639 ENOG4105C8U phosphate abc transporter H6CHR_03640 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H6CHR_03641 ENOG4105C9X ppx gppa phosphatase H6CHR_03643 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H6CHR_03645 ENOG4108JU3 Alkyl hydroperoxide reductase H6CHR_03646 ENOG4105CYM Glutathione S-transferase H6CHR_03655 ENOG4105CD5 CoA-binding domain protein H6CHR_03657 ENOG4105CGU Enoyl-CoA hydratase H6CHR_03658 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_03659 ENOG4105CC9 acyl-Coa dehydrogenase H6CHR_03665 ENOG4105CGU Enoyl-CoA hydratase H6CHR_03666 ENOG41073TP transcriptional regulator H6CHR_03667 ENOG4107U2T alpha beta H6CHR_03668 ENOG4105CPC Aldo Keto reductase H6CHR_03670 ENOG4105X7H acyl-CoA dehydrogenase H6CHR_03673 ENOG4107S2E monooxygenase H6CHR_03675 ENOG4105CHR reductase H6CHR_03681 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H6CHR_03683 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) H6CHR_03685 ENOG4105E2X shikimate dehydrogenase H6CHR_03689 ENOG4107S2E monooxygenase H6CHR_03691 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H6CHR_03693 ENOG4107EFR Flavocytochrome c H6CHR_03704 ENOG4105CHR reductase H6CHR_03706 ENOG4105CHR reductase H6CHR_03707 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_03708 ENOG4105CHR reductase H6CHR_03710 ENOG4108IV0 ABC, transporter H6CHR_03711 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_03712 ENOG4105C6F GntR Family Transcriptional Regulator H6CHR_03719 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_03724 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_03727 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_03730 ENOG4108UW8 fha domain-containing protein H6CHR_03731 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H6CHR_03732 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H6CHR_03738 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H6CHR_03742 ENOG4105E3J oxidoreductase H6CHR_03749 ENOG4105C7F AcnD-accessory protein PrpF H6CHR_03751 ENOG4105F04 LysR family Transcriptional regulator H6CHR_03752 ENOG4105CK2 sodium dicarboxylate symporter H6CHR_03753 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase H6CHR_03756 ENOG4108M9J MaoC like domain protein H6CHR_03758 ENOG4105D8G Major Facilitator superfamily H6CHR_03761 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H6CHR_03762 ENOG4108IPJ Membrane H6CHR_03763 ENOG4105C0R drug resistance transporter emrb qaca subfamily H6CHR_03765 ENOG4108IV0 ABC, transporter H6CHR_03766 ENOG4105C0Z ABC transporter H6CHR_03769 ENOG4105CHR reductase H6CHR_03770 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H6CHR_03772 ENOG41066T0 asmA family H6CHR_03777 ENOG41060WC Enoyl-CoA hydratase H6CHR_03779 ENOG4105K6S Short-chain dehydrogenase reductase Sdr H6CHR_03783 ENOG4107YZX Universal stress protein H6CHR_03785 ENOG4105CCT upf0313 protein H6CHR_03786 ENOG410645S MarR family Transcriptional regulator H6CHR_03791 ENOG4107S2Z UPF0761 membrane protein H6CHR_03794 ENOG4105CPC Aldo Keto reductase H6CHR_03799 ENOG4105C2N RNA methyltransferase TrmH family group 3 H6CHR_03800 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H6CHR_03801 ENOG4108UJV acyl-CoA thioesterase i H6CHR_03803 ENOG4105C28 cystathionine H6CHR_03805 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H6CHR_03806 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) H6CHR_03808 ENOG4105EPW hflc protein H6CHR_03809 ENOG4107QJR hflk protein H6CHR_03810 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H6CHR_03811 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) H6CHR_03812 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H6CHR_03813 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H6CHR_03815 ENOG4105CUT histidyl-tRNA synthetase H6CHR_03816 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) H6CHR_03819 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H6CHR_03820 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H6CHR_03821 ENOG4105FE9 pseudouridine synthase H6CHR_03822 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) H6CHR_03823 ENOG4105C34 Pseudouridine synthase H6CHR_03824 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H6CHR_03825 ENOG4105DVT helicase H6CHR_03829 ENOG4105D6Z AFG1 family ATPase H6CHR_03830 ENOG4107QN2 dihydrolipoyl dehydrogenase H6CHR_03831 ENOG4105C7S Dehydrogenase H6CHR_03832 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H6CHR_03834 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H6CHR_03836 ENOG4108JUA Transcriptional regulator H6CHR_03838 ENOG41082A2 Alpha beta hydrolase H6CHR_03840 ENOG4105ER2 Ompa motb domain protein H6CHR_03844 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H6CHR_03845 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H6CHR_03847 ENOG4105D8V Glucose sorbosone dehydrogenase H6CHR_03848 ENOG4105K4H Nlp p60 protein H6CHR_03849 ENOG4107QN2 dihydrolipoyl dehydrogenase H6CHR_03850 ENOG4107QSN dihydrolipoamide acetyltransferase H6CHR_03851 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H6CHR_03852 ENOG4105BZU Histidine kinase H6CHR_03853 ENOG4108ZXC Two component transcriptional regulator, luxr family H6CHR_03854 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H6CHR_03855 ENOG4105DGW oligopeptidase A H6CHR_03857 ENOG4105E66 phosphoriboisomerase A H6CHR_03858 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) H6CHR_03861 ENOG4105D5U fad dependent oxidoreductase H6CHR_03864 ENOG4107RZZ dna polymerase iii epsilon subunit H6CHR_03865 ENOG4108ZIT Ferredoxin, 2FE-2S H6CHR_03866 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB H6CHR_03867 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) H6CHR_03869 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins H6CHR_03870 ENOG4105C3J Cysteine desulfurase H6CHR_03871 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H6CHR_03873 ENOG4105CGF Aromatic amino acid aminotransferase H6CHR_03875 ENOG4108R3D Electron transport complex H6CHR_03879 ENOG4107QX3 carboxylase H6CHR_03880 ENOG4105DJT lAO AO transport system ATPase H6CHR_03882 ENOG4105DRR Transcriptional regulator, GntR family H6CHR_03886 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H6CHR_03887 ENOG4107QRT dEAD DEAH box helicase H6CHR_03888 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H6CHR_03895 ENOG4105CKD glutathione-regulated potassium-efflux system protein H6CHR_03896 ENOG4105CK2 sodium dicarboxylate symporter H6CHR_03897 ENOG4105CHR reductase H6CHR_03901 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_03902 ENOG4105EGI Transcriptional regulator H6CHR_03903 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_03904 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class H6CHR_03906 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H6CHR_03910 ENOG4108RH0 Crea protein H6CHR_03911 ENOG4108K5P (LipO)protein H6CHR_03912 ENOG4107RZC phospholipase d H6CHR_03915 ENOG4105F04 LysR family Transcriptional regulator H6CHR_03916 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H6CHR_03923 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_03926 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_03932 ENOG4107W7X Aldolase H6CHR_03933 ENOG4105FP9 thiamine pyrophosphate H6CHR_03934 ENOG4105C26 Dehydrogenase H6CHR_03938 ENOG4108UKV benzoate 1,2-dioxygenase H6CHR_03945 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_03947 ENOG4105DND Transcriptional regulator H6CHR_03952 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H6CHR_03953 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H6CHR_03960 ENOG4105DVF Cytosine-specific methyltransferase H6CHR_03974 ENOG4106NZI LysR family Transcriptional regulator H6CHR_03977 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H6CHR_03978 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H6CHR_03981 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_03985 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_03994 ENOG4105C0A alcohol dehydrogenase H6CHR_03995 ENOG4108Z9W Outer membrane porin H6CHR_03998 ENOG4105MP9 class II Aldolase H6CHR_03999 ENOG4108FUF Transcriptional regulator, IclR family H6CHR_04004 ENOG4108T2C cysteine dioxygenase type I H6CHR_04007 ENOG4105HMI Membrane H6CHR_04010 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_04011 ENOG4105FDP GntR family transcriptional regulator H6CHR_04012 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_04015 ENOG4105D5G Transposase H6CHR_04017 ENOG4105E39 Enoyl-CoA hydratase H6CHR_04021 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_04023 ENOG4105C7F AcnD-accessory protein PrpF H6CHR_04024 ENOG4105E39 Enoyl-CoA hydratase H6CHR_04028 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_04037 ENOG4107QJE Chromosome Partitioning Protein H6CHR_04047 ENOG4105FA0 parb-like partition protein H6CHR_04050 ENOG4105W5Q DNA repair protein (RadC H6CHR_04056 ENOG4105DFP Integrase H6CHR_04059 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H6CHR_04060 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H6CHR_04061 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H6CHR_04062 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) H6CHR_04063 ENOG4105VJV 50s ribosomal protein L35 H6CHR_04064 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H6CHR_04065 ENOG4105C22 threonyL-tRNA synthetase H6CHR_04066 ENOG4108I9X Isocitrate lyase H6CHR_04072 ENOG4108W9H Tetr family transcriptional regulator H6CHR_04079 ENOG4107S8A protein TIM barrel H6CHR_04082 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H6CHR_04087 ENOG4105CHH sulfate transporter H6CHR_04088 ENOG4108YZN class I peptide chain release factor H6CHR_04091 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H6CHR_04095 ENOG4106NZI LysR family Transcriptional regulator H6CHR_04097 ENOG4108ZAF Molybdopterin H6CHR_04098 ENOG4105M00 molybdopterin converting factor, subunit 1 H6CHR_04099 ENOG4105CVM Molybdenum cofactor synthesis domain protein H6CHR_04100 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b H6CHR_04101 ENOG4105D98 threonine synthase H6CHR_04102 ENOG4105D6E homoserine dehydrogenase H6CHR_04103 ENOG4105CHM Aminotransferase H6CHR_04105 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H6CHR_04106 ENOG4108IAB Phoh family H6CHR_04109 ENOG4105CDU Replicative dna helicase H6CHR_04110 ENOG4105K9Q Binds to the 23S rRNA (By similarity) H6CHR_04111 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H6CHR_04113 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) H6CHR_04116 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) H6CHR_04117 ENOG4108JU3 Alkyl hydroperoxide reductase H6CHR_04118 ENOG4105D3R alkyl hydroperoxide reductase H6CHR_04120 ENOG4105HB4 Pathways of utilization of iron bound to transferrin, lactoferrin and hemoglobin but not to haemin or citrate where dependent on the TonB system H6CHR_04122 ENOG4105M8F Biopolymer transport protein exbD tolR H6CHR_04124 ENOG4108ZJF Glcg protein H6CHR_04125 ENOG4108MN8 Membrane H6CHR_04126 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H6CHR_04127 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H6CHR_04128 ENOG4108K5P (LipO)protein H6CHR_04129 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) H6CHR_04130 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) H6CHR_04134 ENOG4107TF3 peptidylprolyl cis-trans isomerase H6CHR_04137 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H6CHR_04138 ENOG4105EBM Alpha Beta Hydrolase Fold protein H6CHR_04139 ENOG4105EJC lysr family transcriptional regulator H6CHR_04143 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) H6CHR_04145 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H6CHR_04149 ENOG4105C5I Dehydrogenase H6CHR_04151 ENOG4107RH7 Nicotinate phosphoribosyltransferase H6CHR_04152 ENOG4105VDW Csbd family H6CHR_04155 ENOG4105DGU Histone deacetylase H6CHR_04156 ENOG4108WFY phasin family H6CHR_04158 ENOG4107S2Z UPF0761 membrane protein H6CHR_04159 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H6CHR_04160 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H6CHR_04161 ENOG4105C2C drug resistance transporter, Bcr CflA H6CHR_04164 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_04165 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H6CHR_04169 ENOG4108IV0 ABC, transporter H6CHR_04170 ENOG4105C0Z ABC transporter H6CHR_04175 ENOG4108WYP Transcriptional regulator H6CHR_04179 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H6CHR_04182 ENOG4105E90 ABC transporter H6CHR_04183 ENOG4105C26 Dehydrogenase H6CHR_04184 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase H6CHR_04186 ENOG4107YCY Transcriptional regulator H6CHR_04187 ENOG4105E9Z Nad-dependent epimerase dehydratase H6CHR_04188 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_04190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_04191 ENOG4105CTX dehydratase H6CHR_04193 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) H6CHR_04195 ENOG4105DJ4 phosphatidylserine decarboxylase H6CHR_04197 ENOG4108V1T peptidylprolyl cis-trans isomerase H6CHR_04198 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H6CHR_04199 ENOG4105CFG Acts as a chaperone (By similarity) H6CHR_04200 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H6CHR_04201 ENOG4105ERH Fumarylacetoacetate hydrolase H6CHR_04203 ENOG4105CYN Serine protein kinase H6CHR_04204 ENOG4106AKX UPF0229 protein H6CHR_04205 ENOG4105ED1 spovr family H6CHR_04206 ENOG4108R3E Dna-3-methyladenine glycosylase i H6CHR_04207 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) H6CHR_04208 ENOG4107QPD alcohol dehydrogenase H6CHR_04209 ENOG4105C4W S-formylglutathione hydrolase H6CHR_04210 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H6CHR_04213 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H6CHR_04215 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H6CHR_04217 ENOG4107RZC phospholipase d H6CHR_04220 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H6CHR_04221 ENOG4107S9R deoxycytidine triphosphate deaminase H6CHR_04222 ENOG4107S9R deoxycytidine triphosphate deaminase H6CHR_04229 ENOG4105D4U had-superfamily hydrolase, subfamily iia H6CHR_04230 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H6CHR_04235 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H6CHR_04237 ENOG4107S2Z UPF0761 membrane protein H6CHR_04239 ENOG4105CQB FAD linked oxidase domain protein H6CHR_04240 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H6CHR_04241 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H6CHR_04247 ENOG4105CGK Exodeoxyribonuclease III H6CHR_04249 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H6CHR_04250 ENOG4105CUX Signal transduction histidine kinase H6CHR_04253 ENOG4105CEV competence damage-inducible protein H6CHR_04258 ENOG4105I08 Pseudouridine synthase H6CHR_04260 ENOG4106R49 Methyltransferase H6CHR_04263 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H6CHR_04264 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H6CHR_04265 ENOG4105UYK outer membrane protein a H6CHR_04266 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H6CHR_04268 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) H6CHR_04269 ENOG4105CQC Prephenate dehydratase H6CHR_04271 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H6CHR_04272 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H6CHR_04275 ENOG4105CFV Tetratricopeptide repeat protein H6CHR_04279 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_04280 ENOG4107Z6W Protein CrcB homolog H6CHR_04281 ENOG4105D65 subunit l H6CHR_04282 ENOG4108ZE9 Monovalent cation H antiporter subunit C H6CHR_04283 ENOG4107R4Z monovalent cation h antiporter subunit d H6CHR_04285 ENOG4105W4C monovalent cation H antiporter subunit F H6CHR_04286 ENOG4105KJM monovalent cation h antiporter subunit g H6CHR_04297 ENOG4107T8Q Glycosyl transferase (Group 1 H6CHR_04301 ENOG4108YYC ycei family H6CHR_04305 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family H6CHR_04308 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H6CHR_04314 ENOG4108IJ0 Aspartate ammonia-lyase H6CHR_04315 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H6CHR_04317 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H6CHR_04318 ENOG4105E0C molybdate abc transporter H6CHR_04319 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) H6CHR_04322 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H6CHR_04323 ENOG4105F0N pyrophosphate phospho-hydrolase H6CHR_04324 ENOG4105MWK D-amino acid dehydrogenase, small subunit H6CHR_04328 ENOG4108JJB ABC transporter H6CHR_04330 ENOG4105F4R Transcriptional regulator mode H6CHR_04334 ENOG4108IV0 ABC, transporter H6CHR_04335 ENOG4105C0Z ABC transporter H6CHR_04339 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H6CHR_04340 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit H6CHR_04341 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit H6CHR_04342 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit H6CHR_04343 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit H6CHR_04345 ENOG4108ZJI phenylacetic acid degradation protein H6CHR_04346 ENOG4108UKI Enoyl-CoA hydratase H6CHR_04347 ENOG4108Z0R Transferase H6CHR_04348 ENOG4108IG5 Transcriptional regulator H6CHR_04349 ENOG4105E6M Sulphatase-modifying factor protein H6CHR_04351 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_04357 ENOG4108JJ6 Type I secretion system ATPase H6CHR_04358 ENOG4105CH5 extracellular solute-binding protein, family 7 H6CHR_04359 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H6CHR_04361 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H6CHR_04364 ENOG4105KHC sulfurtransferase H6CHR_04367 ENOG4105D60 lipoprotein releasing system transmembrane protein H6CHR_04369 ENOG4105WKW Pfam:DUF1458 H6CHR_04373 ENOG4107RP9 extracellular solute-binding protein, family 3 H6CHR_04374 ENOG4105MWK D-amino acid dehydrogenase, small subunit H6CHR_04377 ENOG4105C2M dna polymerase I H6CHR_04379 ENOG4105CUV Homoserine Kinase H6CHR_04381 ENOG4105C4R Atp-dependent dna helicase H6CHR_04382 ENOG4108QVN serine threonine protein kinase H6CHR_04383 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) H6CHR_04386 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_04389 ENOG4105C1J atp-dependent rna helicase H6CHR_04390 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) H6CHR_04391 ENOG4105D0M Protease HtpX homolog H6CHR_04392 ENOG41090A4 Pterin carbinolamine dehydratase H6CHR_04393 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H6CHR_04394 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) H6CHR_04395 ENOG4105CIH Imidazole acetol-phosphate transaminase H6CHR_04396 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) H6CHR_04397 ENOG4105P8F nudix hydrolase H6CHR_04398 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H6CHR_04399 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) H6CHR_04400 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) H6CHR_04401 ENOG4105K5M 30s ribosomal protein S16 H6CHR_04404 ENOG4107QXV Phosphate transporter H6CHR_04405 ENOG4107GRR phosphate transport regulator H6CHR_04406 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H6CHR_04407 ENOG4105DJ0 Poly(A) Polymerase H6CHR_04408 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) H6CHR_04409 ENOG4105CXB phosphoribosylaminoimidazole synthetase H6CHR_04410 ENOG4106F5Q Membrane H6CHR_04412 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) H6CHR_04416 ENOG4105CJR Integral membrane protein (MviN H6CHR_04417 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) H6CHR_04419 ENOG4105C8Y Acetylornithine aminotransferase H6CHR_04420 ENOG4105DBV ornithine carbamoyltransferase H6CHR_04421 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) H6CHR_04423 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) H6CHR_04432 ENOG4105MSY salicylate hydroxylase H6CHR_04433 ENOG4105CE1 Ferrous iron transport protein b H6CHR_04435 ENOG4107QM5 aconitate hydratase H6CHR_04438 ENOG4107QIJ Aconitate hydratase 2 H6CHR_04440 ENOG4105CI0 Citrate lyase H6CHR_04441 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) H6CHR_04442 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H6CHR_04443 ENOG4105FDP GntR family transcriptional regulator H6CHR_04446 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H6CHR_04447 ENOG4105E33 succinate dehydrogenase H6CHR_04448 ENOG41060IS Flavinator of succinate dehydrogenase H6CHR_04449 ENOG4105BZN citrate synthase H6CHR_04452 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H6CHR_04453 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H6CHR_04454 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H6CHR_04455 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H6CHR_04457 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H6CHR_04458 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase H6CHR_04459 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H6CHR_04460 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H6CHR_04461 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) H6CHR_04462 ENOG4108VIA integral membrane protein H6CHR_04464 ENOG4105CRK lysyL-tRNA synthetase H6CHR_04465 ENOG4105R8A Heat shock protein H6CHR_04466 ENOG4108VKG metal-dependent hydrolase H6CHR_04468 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) H6CHR_04469 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) H6CHR_04470 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) H6CHR_04471 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H6CHR_04472 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H6CHR_04474 ENOG4105C3F Signal peptidase i H6CHR_04475 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H6CHR_04476 ENOG4105C0H protease H6CHR_04479 ENOG4105EMN RNA polymerase sigma factor H6CHR_04480 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H6CHR_04481 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H6CHR_04482 ENOG4105CHR reductase H6CHR_04483 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H6CHR_04484 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H6CHR_04485 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) H6CHR_04486 ENOG4105VGS 50s ribosomal protein l32 H6CHR_04487 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein H6CHR_04488 ENOG4108UHJ MAF-like protein H6CHR_04489 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H6CHR_04490 ENOG4106UW1 Major Facilitator superfamily H6CHR_04491 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H6CHR_04494 ENOG4105EI2 Pseudouridine synthase H6CHR_04495 ENOG4105C03 ribonuclease H6CHR_04496 ENOG4105D3Q Sugar transferase H6CHR_04498 ENOG4105C30 Nad-dependent epimerase dehydratase H6CHR_04502 ENOG4106CD9 glycosyl transferase group 1 H6CHR_04509 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H6CHR_04510 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) H6CHR_04511 ENOG410642W LysR family Transcriptional regulator H6CHR_04512 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H6CHR_04522 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) H6CHR_04525 ENOG4105D1Q UPF0246 protein H6CHR_04527 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H6CHR_04529 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) H6CHR_04530 ENOG4105E09 nadh pyrophosphatase H6CHR_04531 ENOG4105C6T cysteine synthase H6CHR_04533 ENOG4105VFU Rna-binding protein H6CHR_04537 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_04538 ENOG4105C0H protease H6CHR_04540 ENOG4108YYQ gCN5-related N-acetyltransferase H6CHR_04544 ENOG4108IV0 ABC, transporter H6CHR_04545 ENOG4105C0Z ABC transporter H6CHR_04546 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H6CHR_04547 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_04548 ENOG4105D1H recombination factor protein RarA H6CHR_04549 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) H6CHR_04550 ENOG4105CNU cell division protein FtsK H6CHR_04552 ENOG4105C3M thioredoxin reductase H6CHR_04553 ENOG4105KDC 50s ribosomal protein l28 H6CHR_04554 ENOG4105W0E 50S ribosomal protein L33 H6CHR_04557 ENOG4108V3E phosphoribosylglycinamide formyltransferase H6CHR_04558 ENOG4105X7H acyl-CoA dehydrogenase H6CHR_04559 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_04561 ENOG4105E39 Enoyl-CoA hydratase H6CHR_04563 ENOG4105DTN riboflavin biosynthesis protein ribF H6CHR_04565 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) H6CHR_04566 ENOG4105EAM Na Pi-cotransporter H6CHR_04567 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H6CHR_04568 ENOG4105CHR reductase H6CHR_04570 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H6CHR_04574 ENOG4107QHF type ii secretion system protein e H6CHR_04575 ENOG4105I7M spermidine synthase H6CHR_04578 ENOG4105EYA deoxyribonuclease H6CHR_04579 ENOG4105C0H protease H6CHR_04580 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H6CHR_04584 ENOG4105RQF LysR family Transcriptional regulator H6CHR_04586 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H6CHR_04591 ENOG4105CAF HipA N-terminal domain protein H6CHR_04593 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H6CHR_04596 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H6CHR_04600 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase H6CHR_04601 ENOG4105BZU Histidine kinase H6CHR_04602 ENOG4108YZ9 Urea amidohydrolase subunit gamma H6CHR_04604 ENOG4105KI2 Urea amidohydrolase subunit beta H6CHR_04605 ENOG4105CQM Urea amidohydrolase subunit alpha H6CHR_04606 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) H6CHR_04607 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) H6CHR_04608 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) H6CHR_04610 ENOG4105C7K acetolactate synthase H6CHR_04616 ENOG4105CSA Coproporphyrinogen iii oxidase H6CHR_04617 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H6CHR_04618 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H6CHR_04620 ENOG4105D9P serine threonine protein kinase H6CHR_04621 ENOG4105DSJ YicC domain protein H6CHR_04622 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H6CHR_04623 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) H6CHR_04624 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H6CHR_04625 ENOG4108RRZ Transcription elongation factor GreB H6CHR_04628 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) H6CHR_04629 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H6CHR_04630 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H6CHR_04631 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H6CHR_04632 ENOG4105CEN a g-specific adenine glycosylase H6CHR_04633 ENOG410890F Dynamin family H6CHR_04634 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H6CHR_04637 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) H6CHR_04639 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H6CHR_04640 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) H6CHR_04641 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H6CHR_04643 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H6CHR_04645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H6CHR_04647 ENOG4108JQ7 (ABC) transporter H6CHR_04648 ENOG4105DEF Extracellular solute-binding protein, family 5 H6CHR_04649 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H6CHR_04650 ENOG4107NQ8 LysR family Transcriptional regulator H6CHR_04656 ENOG4105CVJ phosphoglycerate mutase H6CHR_04657 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) H6CHR_04658 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H6CHR_04659 ENOG4107QSN dihydrolipoamide acetyltransferase H6CHR_04660 ENOG4107QN2 dihydrolipoyl dehydrogenase H6CHR_04661 ENOG4105EV9 Alpha Beta Hydrolase H6CHR_04662 ENOG4105C6K Malic enzyme H6CHR_04664 ENOG4105CEP NADH dehydrogenase H6CHR_04665 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class H6CHR_04666 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_04667 ENOG4105CHR reductase H6CHR_04669 ENOG4105C4M (Ubiquinol oxidase) subunit I H6CHR_04670 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H6CHR_04671 ENOG4105CQZ Histidine kinase H6CHR_04672 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H6CHR_04673 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) H6CHR_04674 ENOG4105E7W lamb ycsf family protein H6CHR_04675 ENOG4107R7A Allophanate hydrolase subunit 2 H6CHR_04676 ENOG4105P4J Allophanate hydrolase, subunit 1 H6CHR_04677 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H6CHR_04678 ENOG4106H78 methyltransferase H6CHR_04683 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H6CHR_04685 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H6CHR_04690 ENOG4107QS1 Cytochrome C Oxidase, Subunit III H6CHR_04692 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) H6CHR_04694 ENOG4105BZ9 Cytochrome C oxidase, subunit I H6CHR_04697 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H6CHR_04699 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H6CHR_04702 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein H6CHR_04705 ENOG4105E9F Enoyl-CoA hydratase H6CHR_04709 ENOG4105CSU acyl-Coa dehydrogenase H6CHR_04714 ENOG4105CIF Ornithine Cyclodeaminase H6CHR_04715 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_04716 ENOG4107QNJ CoA-transferase subunit B H6CHR_04718 ENOG4107HP6 Transcriptional regulator H6CHR_04721 ENOG4105K70 DNA-binding protein H6CHR_04722 ENOG4105DIA mandelate racemase muconate lactonizing H6CHR_04723 ENOG4105CG3 alpha amylase, catalytic region H6CHR_04724 ENOG4105CG3 alpha amylase, catalytic region H6CHR_04725 ENOG4105EWI Short-chain dehydrogenase reductase Sdr H6CHR_04726 ENOG4108PZW LysR family Transcriptional regulator H6CHR_04728 ENOG4108ERU trap dicarboxylate transporter subunit DctP H6CHR_04732 ENOG4105ZXK Dehydrogenase H6CHR_04736 ENOG4105CW7 secretion protein, HlyD family H6CHR_04737 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H6CHR_04739 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) H6CHR_04741 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H6CHR_04742 ENOG4106P55 Transcriptional regulator H6CHR_04745 ENOG4105ESI atpase involved in dna repair H6CHR_04748 ENOG4105D44 asparaginase H6CHR_04749 ENOG4108JQ6 ABC transporter H6CHR_04750 ENOG4105DEF Extracellular solute-binding protein, family 5 H6CHR_04752 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H6CHR_04761 ENOG4105GVR general secretion pathway protein D H6CHR_04766 ENOG4107QHF type ii secretion system protein e H6CHR_04767 ENOG4105D7Q type ii secretion system H6CHR_04768 ENOG4108VAU general secretion pathway protein G H6CHR_04776 ENOG4108IV0 ABC, transporter H6CHR_04777 ENOG4108IUZ ABC transporter H6CHR_04780 ENOG4105C26 Dehydrogenase H6CHR_04783 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H6CHR_04792 ENOG4105CHR reductase H6CHR_04793 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H6CHR_04794 ENOG4105CC0 LysR family Transcriptional regulator H6CHR_04796 ENOG4105DDW LysR family Transcriptional regulator H6CHR_04799 ENOG4106RE7 Cytochrome H6CHR_04800 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H6CHR_04816 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H6CHR_04819 ENOG4108Z20 Acyl-transferase H6CHR_04820 ENOG4105CD3 dihydroorotase H6CHR_04821 ENOG4105CXT aspartate transcarbamylase H6CHR_04822 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) H6CHR_04823 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H6CHR_04824 ENOG4108UJU UPF0301 protein H6CHR_04825 ENOG4105CVP deoxyribo-dipyrimidine photolyase H6CHR_04827 ENOG4105C8Q Methyl-accepting chemotaxis H6CHR_04829 ENOG4105M3Z response regulator H6CHR_04830 ENOG4108UNF response regulator H6CHR_04831 ENOG4105VCQ rubredoxin H6CHR_04833 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H6CHR_04834 ENOG4105DC1 bifunctional purine biosynthesis protein purh H6CHR_04836 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H6CHR_04837 ENOG4105W39 Membrane H6CHR_04838 ENOG4105C3G gtp-binding protein H6CHR_04839 ENOG4105QVC MOSC domain-containing protein H6CHR_04840 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H6CHR_04843 ENOG4105E39 Enoyl-CoA hydratase H6CHR_04852 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H6CHR_04853 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase H6CHR_04854 ENOG4105E8V Alpha Beta Hydrolase Fold protein H6CHR_04855 ENOG41077RS Phosphatase H6CHR_04858 ENOG4108HPI phosphatidate Cytidylyltransferase H6CHR_04859 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H6CHR_04860 ENOG4105C9A Phoh family H6CHR_04861 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H6CHR_04862 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H6CHR_04867 ENOG4105DR5 peptidase H6CHR_04868 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) H6CHR_04869 ENOG4105C0R drug resistance transporter emrb qaca subfamily H6CHR_04870 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H6CHR_04871 ENOG4108UJD 30S ribosomal protein S9 H6CHR_04872 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H6CHR_04873 ENOG4105D6S protein involved in catabolism of external DNA H6CHR_04875 ENOG4105SYT Methylenetetrahydrofolate reductase H6CHR_04877 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) H6CHR_04879 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) H6CHR_04885 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_04890 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H6CHR_04891 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H6CHR_04894 ENOG4105CSH Transporter H6CHR_04898 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H6CHR_04899 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase H6CHR_04901 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) H6CHR_04902 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H6CHR_04904 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H6CHR_04907 ENOG4108IPT Naphthoate synthase H6CHR_04909 ENOG4107QX3 carboxylase H6CHR_04910 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_04911 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_04914 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 H6CHR_04915 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) H6CHR_04919 ENOG4105K5B UPF0225 protein H6CHR_04922 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_04925 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_04926 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) H6CHR_04927 ENOG41077A9 carbonic anhydrase H6CHR_04928 ENOG4108Z6Z Transcriptional regulator H6CHR_04931 ENOG4105EI2 Pseudouridine synthase H6CHR_04932 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_04933 ENOG4105BZU Histidine kinase H6CHR_04934 ENOG4105CHR reductase H6CHR_04937 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H6CHR_04938 ENOG4105C38 Glycyl-tRNA synthetase beta subunit H6CHR_04939 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit H6CHR_04940 ENOG4105HDK L-asparaginase H6CHR_04942 ENOG4105CG3 alpha amylase, catalytic region H6CHR_04943 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H6CHR_04944 ENOG4108JU5 Magnesium and cobalt efflux protein H6CHR_04948 ENOG4105F87 Dehydratase H6CHR_04950 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_04956 ENOG4105C5H ABC transporter H6CHR_04957 ENOG4107RZC phospholipase d H6CHR_04958 ENOG4105CHM Aminotransferase H6CHR_04960 ENOG4105T38 integral membrane protein H6CHR_04961 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H6CHR_04963 ENOG4108NIW Leucine export protein LeuE H6CHR_04964 ENOG4108TGY Glutathione S-transferase H6CHR_04965 ENOG4105JAB phenazine biosynthesis protein, phzf family H6CHR_04970 ENOG4105F4K antigen 43 H6CHR_04972 ENOG4105VF7 tolerance protein H6CHR_04975 ENOG4108V1U phospholipid-binding protein H6CHR_04978 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H6CHR_04979 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) H6CHR_04980 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H6CHR_04981 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H6CHR_04982 ENOG4105C25 Primosomal protein n' H6CHR_04985 ENOG4105RK9 auxin efflux carrier H6CHR_04986 ENOG4105C4R Atp-dependent dna helicase H6CHR_04988 ENOG4105HDD phospholipase H6CHR_04990 ENOG4105C1G acyl-Coa dehydrogenase H6CHR_04991 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_04992 ENOG4105DND Transcriptional regulator H6CHR_04994 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H6CHR_05007 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_05012 ENOG4105CKT filamentous hemagglutinin H6CHR_05016 ENOG4105CPT Alpha beta hydrolase H6CHR_05017 ENOG4108WYP Transcriptional regulator H6CHR_05018 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein H6CHR_05019 ENOG4108IY8 ABC, transporter H6CHR_05020 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H6CHR_05025 ENOG4105ES5 Histidine kinase H6CHR_05027 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H6CHR_05029 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H6CHR_05030 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H6CHR_05031 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) H6CHR_05032 ENOG4108VZM 50s ribosomal protein L10 H6CHR_05033 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) H6CHR_05034 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) H6CHR_05036 ENOG4105PM1 preprotein translocase subunit SecE H6CHR_05038 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H6CHR_05042 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H6CHR_05043 ENOG4105DK0 Indole-3-glycerol phosphate synthase H6CHR_05044 ENOG4107QYG anthranilate phosphoribosyltransferase H6CHR_05045 ENOG410829K Lysine exporter protein (Lyse ygga) H6CHR_05047 ENOG4105DDQ anthranilate synthase H6CHR_05052 ENOG4105CHR reductase H6CHR_05053 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_05054 ENOG4108IV0 ABC, transporter H6CHR_05056 ENOG4105C0Z ABC transporter H6CHR_05057 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_05058 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H6CHR_05063 ENOG4105CHR reductase H6CHR_05064 ENOG4106IPI cyclase, family H6CHR_05066 ENOG4105CHU acetyl-coa acetyltransferase H6CHR_05069 ENOG4105FUY alpha subunit H6CHR_05075 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H6CHR_05077 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H6CHR_05079 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H6CHR_05086 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H6CHR_05094 ENOG4108ZF3 Phosphatase H6CHR_05095 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H6CHR_05103 ENOG4105EHI Phosphonate ABC transporter, periplasmic H6CHR_05104 ENOG4105EHI Phosphonate ABC transporter, periplasmic H6CHR_05105 ENOG4105BZU Histidine kinase H6CHR_05108 ENOG4108IG5 Transcriptional regulator H6CHR_05115 ENOG4105C0Z ABC transporter H6CHR_05116 ENOG4108IV0 ABC, transporter H6CHR_05118 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_05119 ENOG4108Z7G MaoC domain protein dehydratase H6CHR_05120 ENOG4105E39 Enoyl-CoA hydratase H6CHR_05125 ENOG4105C75 arginyL-tRNA synthetase H6CHR_05128 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA H6CHR_05129 ENOG4108IUZ ABC transporter H6CHR_05130 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H6CHR_05131 ENOG4107RZC phospholipase d H6CHR_05132 ENOG4105ETE Transcriptional regulator (LacI family H6CHR_05133 ENOG4105CXK mandelate racemase muconate lactonizing H6CHR_05137 ENOG4107V59 shikimate H6CHR_05141 ENOG41073TP transcriptional regulator H6CHR_05148 ENOG4105ENE Histidine kinase H6CHR_05149 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_05150 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H6CHR_05152 ENOG4105NVB glycoside hydrolase, family 19 H6CHR_05155 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H6CHR_05163 ENOG4105WH1 Two component transcriptional regulator luxr family H6CHR_05164 ENOG4105BZU Histidine kinase H6CHR_05167 ENOG4108IMY Transcriptional regulator H6CHR_05168 ENOG4107W7X Aldolase H6CHR_05169 ENOG4105CH5 extracellular solute-binding protein, family 7 H6CHR_05171 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H6CHR_05172 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) H6CHR_05174 ENOG4105NWN ApaG protein H6CHR_05175 ENOG4105DJV ribulose-phosphate 3-epimerase H6CHR_05178 ENOG4105DQE DNA ligase H6CHR_05182 ENOG4107TYG Oxidoreductase domain-containing protein H6CHR_05183 ENOG4105CQB FAD linked oxidase domain protein H6CHR_05184 ENOG4108IV0 ABC, transporter H6CHR_05185 ENOG4105CP9 extracellular ligand-binding receptor H6CHR_05186 ENOG4105C0Z ABC transporter H6CHR_05187 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_05188 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H6CHR_05189 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_05190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H6CHR_05191 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter H6CHR_05192 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H6CHR_05194 ENOG4105CMT Dihydroxyacetone kinase H6CHR_05195 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H6CHR_05196 ENOG41069M3 Transcriptional regulator H6CHR_05198 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H6CHR_05202 ENOG4105ETE Transcriptional regulator (LacI family H6CHR_05203 ENOG4106PBJ Serine threonine-protein kinase Pkn6 H6CHR_05212 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_05213 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H6CHR_05217 ENOG4105CIH Imidazole acetol-phosphate transaminase H6CHR_05218 ENOG4107QP3 malate synthase g H6CHR_05223 ENOG4105ETT transcriptional Regulator, LysR family H6CHR_05228 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 H6CHR_05231 ENOG4105C0R drug resistance transporter emrb qaca subfamily H6CHR_05232 ENOG4105E7A Glutamine amidotransferase H6CHR_05236 ENOG4105D7Z glutathione synthase H6CHR_05237 ENOG4105DKK Benzoate H6CHR_05238 ENOG4105DFH Transport of potassium into the cell (By similarity) H6CHR_05240 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) H6CHR_05243 ENOG4105C8T Leucyl-tRNA synthetase H6CHR_05244 ENOG4105SG9 biopolymer transport protein, ExbD H6CHR_05246 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H6CHR_05247 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H6CHR_05248 ENOG41090R7 Ferric uptake H6CHR_05249 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) H6CHR_05250 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN H6CHR_05251 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA H6CHR_05252 ENOG4105C4R Atp-dependent dna helicase H6CHR_05253 ENOG4107QUT magnesium and cobalt transport protein CorA H6CHR_05255 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) H6CHR_05256 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_05257 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H6CHR_05258 ENOG4105W8H transhydrogenase (subunit alpha H6CHR_05259 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H6CHR_05260 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H6CHR_05261 ENOG4105EEX Two component transcriptional regulator (Winged helix family H6CHR_05264 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H6CHR_05266 ENOG4105DEN Luciferase family H6CHR_05270 ENOG4105D3Q Sugar transferase H6CHR_05276 ENOG4108MX3 Polysaccharide Biosynthesis Protein H6CHR_05277 ENOG4108IAJ Nad-dependent epimerase dehydratase H6CHR_05278 ENOG4107QQG Dehydrogenase H6CHR_05282 ENOG4108UUM single-stranded DNA-binding protein H6CHR_05283 ENOG4105CMQ Chloride channel H6CHR_05285 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H6CHR_05291 ENOG4105MSY salicylate hydroxylase H6CHR_05294 ENOG4108KB2 LysR family Transcriptional regulator H6CHR_05296 ENOG4105BZU Histidine kinase H6CHR_05298 ENOG4105ETX regulatoR H6CHR_05299 ENOG4105ERH Fumarylacetoacetate hydrolase H6CHR_05300 ENOG4105F1J Homogentisate 1,2-dioxygenase H6CHR_05302 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase H6CHR_05308 ENOG4105SKN orotidine 5''-phosphate decarboxylase H6CHR_05310 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H6CHR_05311 ENOG41072GX Peptidase M22 Glycoprotease H6CHR_05314 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H6CHR_05315 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H6CHR_05316 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H6CHR_05317 ENOG4107QR8 Thioredoxin H6CHR_05319 ENOG4107RYR Transcriptional regulator, Crp Fnr family H6CHR_05321 ENOG4105C8V SAICAR synthetase H6CHR_05323 ENOG4105CA9 Pyruvate kinase H6CHR_05324 ENOG4105BZA Phosphoglycerate kinase H6CHR_05325 ENOG4105DUM transcriptional regulator, lysR family H6CHR_05328 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase H6CHR_05332 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H6CHR_05334 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H6CHR_05336 ENOG4105C79 DNA protecting protein DprA H6CHR_05337 ENOG4108RPN Protein smg homolog H6CHR_05340 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H6CHR_05341 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H6CHR_05342 ENOG4105VIE preprotein translocase, subunit YajC H6CHR_05344 ENOG4108YXU transcriptional regulator AsnC family H6CHR_05345 ENOG4107SFI Major Facilitator superfamily H6CHR_05346 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H6CHR_05352 ENOG4107TTD cytosine deaminase H6CHR_05353 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H6CHR_05354 ENOG4105FB2 class II Aldolase H6CHR_05355 ENOG4105G63 Type III effector Hrp-dependent H6CHR_05356 ENOG4105ZXK Dehydrogenase H6CHR_05359 ENOG4105C1J atp-dependent rna helicase H6CHR_05360 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H6CHR_05361 ENOG4105C0H protease H6CHR_05363 ENOG4108Z86 Glutamine amidotransferase H6CHR_05367 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase H6CHR_05373 ENOG4105DHQ Histidine kinase H6CHR_05376 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H6CHR_05377 ENOG4108004 Modulates RecA activity (By similarity) H6CHR_05378 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H6CHR_05379 ENOG4105CMV Succinyl-CoA synthetase subunit beta H6CHR_05380 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H6CHR_05381 ENOG4108ZCF integral membrane protein H6CHR_05382 ENOG4108ZF3 Phosphatase H6CHR_05384 ENOG4105F8J Adenylate Guanylate cyclase H6CHR_05386 ENOG4105KHS type IV fimbrial pilin protein H6CHR_05394 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H6CHR_05395 ENOG4105ERG peptidase m48, ste24p H6CHR_05396 ENOG41086DT Membrane protein of unknown function H6CHR_05398 ENOG4108ZCF integral membrane protein H6CHR_05402 ENOG4108VWS Yaeq family H6CHR_05403 ENOG4107QTF adenylosuccinate lyase H6CHR_05405 ENOG4108M3P Membrane H6CHR_05406 ENOG4108U78 Glutathione S-transferase H6CHR_05409 ENOG4108KPJ rna polymerase sigma factor H6CHR_05410 ENOG4105K6T rare lipoprotein A H6CHR_05411 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) H6CHR_05414 ENOG4105BZU Histidine kinase H6CHR_05415 ENOG4108ZXC Two component transcriptional regulator, luxr family H6CHR_05416 ENOG4105KCK Peptidoglycan-associated lipoprotein H6CHR_05418 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) H6CHR_05422 ENOG4108YXU transcriptional regulator AsnC family H6CHR_05423 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H6CHR_05424 ENOG4108RZE Tetr family transcriptional regulator H6CHR_05425 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase H6CHR_05431 ENOG4105CEV competence damage-inducible protein H6CHR_05432 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H6CHR_05434 ENOG4107JEE Short-chain dehydrogenase reductase Sdr H6CHR_05435 ENOG4108YZY peptidylprolyl cis-trans isomerase H6CHR_05438 ENOG4105EUB pirin domain protein H6CHR_05440 ENOG4105CPC Aldo Keto reductase H6CHR_05444 ENOG4105BZ9 Cytochrome C oxidase, subunit I H6CHR_05445 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) H6CHR_05447 ENOG4108Q1J Extracellular solute-binding protein, family 3 H6CHR_05448 ENOG4105DZG Dehydrogenase H6CHR_05451 ENOG4105HSS phospholipase C H6CHR_05452 ENOG4105C08 Histidine kinase H6CHR_05453 ENOG4105EHU Circadian clock protein KaiC H6CHR_05457 ENOG4105C9U ATP-dependent DNA helicase RecQ H6CHR_05471 ENOG4108IAJ Nad-dependent epimerase dehydratase H6CHR_05472 ENOG4105CPQ Dehydrogenase H6CHR_05473 ENOG4105CK5 oxidoreductase H6CHR_05480 ENOG4105BZU Histidine kinase H6CHR_05482 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H6CHR_05484 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H6CHR_05485 ENOG4105WEF catalase H6CHR_05490 ENOG4105EEF Alkane 1-monooxygenase H6CHR_05494 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) H6CHR_05495 ENOG4108IV0 ABC, transporter H6CHR_05496 ENOG4108IUZ ABC transporter H6CHR_05497 ENOG4105C32 Amino acid ABC transporter (Permease) H6CHR_05500 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H6CHR_05503 ENOG4105DND Transcriptional regulator H6CHR_05506 ENOG4105CEY Amp-dependent synthetase and ligase H6CHR_05510 ENOG4105ECQ AraC Family Transcriptional Regulator H6CHR_05516 ENOG4105DTQ mandelate racemase muconate lactonizing H6CHR_05519 ENOG4105ERH Fumarylacetoacetate hydrolase H6CHR_05520 ENOG4105EMU Dehydrogenase H6CHR_05523 ENOG4105C0B DNA polymerase III (alpha subunit) H6CHR_05534 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H6CHR_05536 ENOG4107U9T Pfam:Ribonuclease_BN H6CHR_05551 ENOG4105MSY salicylate hydroxylase H6CHR_05553 ENOG4108RF4 Tetr family transcriptional regulator H6CHR_05557 ENOG41061M1 UPF0337 protein H6CHR_05563 ENOG4105CQB FAD linked oxidase domain protein H6CHR_05565 ENOG4105C5R Aminotransferase H6CHR_05568 ENOG4108VX5 3-methyladenine DNA glycosylase H6CHR_05576 ENOG4105DZR Type I site-specific deoxyribonuclease H6CHR_05581 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H6CHR_05582 ENOG4105CV1 Transketolase (EC 2.2.1.1) H6CHR_05583 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) H6CHR_05584 ENOG4108S0S Nucleotidyl transferase H6CHR_05588 ENOG4107RAQ aminopeptidase H6CHR_05596 ENOG4105C6K Malic enzyme H6CHR_05600 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H6CHR_05601 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H6CHR_05602 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) H6CHR_05603 ENOG4105EHM Aminoglycoside phosphotransferase H6CHR_05604 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H6CHR_05606 ENOG4105VP5 Bacterial protein of unknown function (DUF937) H6CHR_05607 ENOG4105DXI Major Facilitator superfamily H6CHR_05611 ENOG4105EYW Ion transport protein H6CHR_05612 ENOG4105DWV Homoserine O-trans-acetylase H6CHR_05613 ENOG4105DWV Homoserine O-trans-acetylase H6CHR_05615 ENOG4105VFU Rna-binding protein H6CHR_05616 ENOG4107FW0 short-chain dehydrogenase reductase H6CHR_05618 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase H6CHR_05619 ENOG4105C2X Arabinose 5-phosphate isomerase H6CHR_05623 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H6CHR_05624 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H6CHR_05625 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H6CHR_05626 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) H6P1_00005 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H6P1_00011 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H6P1_00012 ENOG4105E4C Lytic transglycosylase catalytic H6P1_00013 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H6P1_00015 ENOG4105F5W AtP-binding protein H6P1_00016 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H6P1_00017 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) H6P1_00024 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H6P1_00031 ENOG4105C4R Atp-dependent dna helicase H6P1_00056 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H6P1_00071 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H6P1_00072 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor H6P1_00080 ENOG4105C7H Helicase, RecD TraA family H6P1_00081 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H6P1_00094 ENOG4105DQE DNA ligase H6P1_00095 ENOG4105SG9 biopolymer transport protein, ExbD H6P1_00097 ENOG4108PAU MotA TolQ exbB proton channel H6P1_00108 ENOG4105C2M dna polymerase I H6P1_00122 ENOG4108UUM single-stranded DNA-binding protein H6P1_00132 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H6P1_00157 ENOG4105K63 Thioredoxin H6P1_00165 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H6P1_00186 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H6P1_00190 ENOG4105F5W AtP-binding protein H6P1_00191 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H6P1_00193 ENOG4108ZQS transposase H6P1_00201 ENOG4105CEC DNA methylase N-4 N-6 H6P1_00216 ENOG4107RH7 Nicotinate phosphoribosyltransferase H6P1_00232 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate H6P1_00251 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H6P1_00254 ENOG4108R1E Serine threonine protein phosphatase 1 H6P1_00262 ENOG4105DVT helicase H6P1_00271 ENOG4105D7V transposase H6P1_00285 ENOG4105D7V transposase H6P1_00291 ENOG4105C2J ABC transporter H6P1_00293 ENOG4105IPI Membrane H6P1_00295 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H6P1_00299 ENOG4108D1K outer membrane usher protein H6P1_00301 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H6P1_00306 ENOG4107S78 Band 7 protein H6P1_00367 ENOG4105F8V Hydrolase, tatD family H6P1_00377 ENOG4105D1H recombination factor protein RarA H6P1_00391 ENOG4105C0B DNA polymerase III (alpha subunit) H6P1_00392 ENOG4105DTT CRISPR-associated helicase, cas3 H6P1_00393 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) H6P1_00405 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H6P1_00448 ENOG4105D7V transposase H6P1_00457 ENOG4107RA1 nh(3)-dependent nad( ) synthetase H6P1_00462 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H6P1_00470 ENOG4105BZU Histidine kinase H6P1_00478 ENOG4105CYB regulatoR H6P1_00489 ENOG4108ZUW Major pilin subunit H6P1_00517 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H6P1_00522 ENOG4105F5W AtP-binding protein H6P1_00554 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H6P1_00558 ENOG4107RQ0 Maleylacetate reductase H6P1_00564 ENOG4105CMM transposase H6P1_00571 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit H6P1_00574 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit H6P1_00576 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H6P1_00583 ENOG4108KBP metal-dependent protein hydrolase H6P1_00590 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation H6P1_00608 ENOG4105EIN peptidylprolyl cis-trans isomerase H6P1_00629 ENOG4106IJN integrase catalytic domain-containing protein H6P1_00659 ENOG4105C8N cysteinyl-tRNA synthetase H6P1_00683 ENOG4105CVR type I restriction-modification system H6P1_00704 ENOG4105KIR Thiol-disulfide oxidoreductase dcc H6P1_00708 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H6P1_00718 ENOG4105EEQ Na H antiporter H6P1_00720 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H6P1_00727 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H6P1_00747 ENOG4108V1T peptidylprolyl cis-trans isomerase H6P1_00749 ENOG4105K70 DNA-binding protein H6P1_00762 ENOG4105BZU Histidine kinase H6P1_00783 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H6P1_00788 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H6P1_00797 ENOG4105C9U ATP-dependent DNA helicase RecQ H6P1_00812 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H6P1_00817 ENOG4108Z12 YiaAB two helix domain-containing protein H6P1_00871 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H6P1_00872 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) H6P1_00880 ENOG4107S1Q Phosphatase H6P1_00881 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H6P1_00886 ENOG4107QHF type ii secretion system protein e H6P1_00897 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H6P1_00900 ENOG4105CZX twitching motility protein H6P1_00904 ENOG4107QHF type ii secretion system protein e H6P1_00930 ENOG4105DVT helicase H6P1_00933 ENOG4107QJE Chromosome Partitioning Protein H6P2_00014 ENOG4105CMA conjugation trbi family protein H6P2_00022 ENOG4106D0Q Type IV secretion system protein VirB2 H6P2_00040 ENOG4105W5Q DNA repair protein (RadC