locus-tag	class	description
H6CHR_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H6CHR_00006	COG1408	metallophosphoesterase
H6CHR_00008	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H6CHR_00011	COG0392	lysyltransferase activity
H6CHR_00012	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_00013	COG3568	Endonuclease Exonuclease Phosphatase
H6CHR_00018	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H6CHR_00025	COG2205	protein histidine kinase activity
H6CHR_00026	COG0745	RESPONSE REGULATOR receiver
H6CHR_00028	COG2608	mercury ion transmembrane transporter activity
H6CHR_00030	COG0642	Histidine kinase
H6CHR_00031	COG1902	pentaerythritol trinitrate reductase activity
H6CHR_00032	COG0477	Major facilitator Superfamily
H6CHR_00036	COG0445	tRNA wobble uridine modification
H6CHR_00037	COG0357	Ribosomal RNA small subunit methyltransferase G
H6CHR_00039	COG1192	Involved in chromosome partitioning
H6CHR_00041	COG1475	DNA binding
H6CHR_00043	COG0277	FAD linked oxidase domain protein
H6CHR_00044	COG2096	Adenosyltransferase
H6CHR_00052	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H6CHR_00054	COG0850	regulation of cytokinetic process
H6CHR_00056	COG2233	PERMEase
H6CHR_00057	COG2050	protein possibly involved in aromatic compounds catabolism
H6CHR_00060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H6CHR_00068	COG3246	L-lysine catabolic process to acetate
H6CHR_00078	COG3246	L-lysine catabolic process to acetate
H6CHR_00079	COG2175	clavaminate synthase activity
H6CHR_00083	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H6CHR_00088	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H6CHR_00095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H6CHR_00099	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H6CHR_00104	COG2124	cytochrome p450
H6CHR_00105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H6CHR_00106	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_00110	COG2205	protein histidine kinase activity
H6CHR_00110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6CHR_00111	COG0484	heat shock protein binding
H6CHR_00113	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00119	COG1309	transcriptional regulator
H6CHR_00123	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_00127	COG0745	RESPONSE REGULATOR receiver
H6CHR_00130	COG0740	serine-type endopeptidase activity
H6CHR_00139	COG3842	ATPase activity
H6CHR_00140	COG1176	ABC-type spermidine putrescine transport system, permease component I
H6CHR_00141	COG1177	transmembrane transport
H6CHR_00144	COG0251	oxidation-reduction process
H6CHR_00147	COG2267	carboxylic ester hydrolase activity
H6CHR_00154	COG0181	hydroxymethylbilane synthase activity
H6CHR_00159	COG0791	NLP P60 protein
H6CHR_00161	COG0596	Alpha beta hydrolase
H6CHR_00162	COG2205	protein histidine kinase activity
H6CHR_00163	COG0583	DNA-binding transcription factor activity
H6CHR_00164	COG0604	alcohol dehydrogenase
H6CHR_00166	COG1024	Enoyl-CoA hydratase
H6CHR_00168	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_00175	COG1051	belongs to the nudix hydrolase family
H6CHR_00176	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00177	COG2201	protein-glutamate methylesterase activity
H6CHR_00179	COG4628	conserved protein (DUF2132)
H6CHR_00182	COG1752	Esterase of the alpha-beta hydrolase superfamily
H6CHR_00189	COG1881	PFAM PEBP family protein
H6CHR_00198	COG0583	DNA-binding transcription factor activity
H6CHR_00200	COG1024	Enoyl-CoA hydratase
H6CHR_00203	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_00207	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H6CHR_00210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H6CHR_00211	COG2814	Major facilitator Superfamily
H6CHR_00212	COG1950	PFAM Membrane protein of
H6CHR_00216	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6CHR_00217	COG0450	alkyl hydroperoxide reductase
H6CHR_00218	COG0583	DNA-binding transcription factor activity
H6CHR_00219	COG1960	acyl-CoA dehydrogenase activity
H6CHR_00220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_00224	COG4221	oxidoreductase activity
H6CHR_00228	COG3246	L-lysine catabolic process to acetate
H6CHR_00230	COG3485	protocatechuate 3,4-dioxygenase
H6CHR_00231	COG1609	Transcriptional regulator
H6CHR_00236	COG2066	Belongs to the glutaminase family
H6CHR_00239	COG0402	S-adenosylhomocysteine deaminase activity
H6CHR_00242	COG2188	Transcriptional regulator
H6CHR_00243	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H6CHR_00244	COG0700	Nucleoside recognition
H6CHR_00245	COG3540	Alkaline phosphatase
H6CHR_00250	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H6CHR_00252	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H6CHR_00253	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6CHR_00261	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_00264	COG2986	histidine ammonia-lyase
H6CHR_00265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H6CHR_00270	COG1228	amidohydrolase
H6CHR_00278	COG0583	DNA-binding transcription factor activity
H6CHR_00280	COG1410	methionine synthase
H6CHR_00280	COG0646	methionine synthase
H6CHR_00286	COG1309	transcriptional regulator
H6CHR_00295	COG0411	ABC transporter
H6CHR_00297	COG1335	isochorismatase
H6CHR_00298	COG2080	2 iron, 2 sulfur cluster binding
H6CHR_00299	COG2010	Cytochrome c
H6CHR_00299	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H6CHR_00302	COG0606	chelatase, subunit chli
H6CHR_00310	COG0347	Belongs to the P(II) protein family
H6CHR_00311	COG0004	ammonium transporteR
H6CHR_00313	COG0277	FAD linked oxidase domain protein
H6CHR_00314	COG0247	lactate metabolic process
H6CHR_00315	COG3391	amine dehydrogenase activity
H6CHR_00317	COG0386	Belongs to the glutathione peroxidase family
H6CHR_00319	COG0477	Major facilitator Superfamily
H6CHR_00320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H6CHR_00322	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H6CHR_00324	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_00325	COG0129	dihydroxy-acid dehydratase activity
H6CHR_00327	COG3971	2-oxopent-4-enoate hydratase activity
H6CHR_00329	COG3384	dioxygenase
H6CHR_00330	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_00334	COG1846	Transcriptional regulator
H6CHR_00338	COG2974	May be involved in recombination
H6CHR_00343	COG0745	RESPONSE REGULATOR receiver
H6CHR_00351	COG4221	oxidoreductase activity
H6CHR_00354	COG0583	DNA-binding transcription factor activity
H6CHR_00355	COG0708	Exodeoxyribonuclease III
H6CHR_00356	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H6CHR_00358	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H6CHR_00359	COG0154	amidase activity
H6CHR_00360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H6CHR_00361	COG1077	Cell shape determining protein MreB Mrl
H6CHR_00364	COG0768	penicillin binding
H6CHR_00366	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H6CHR_00367	COG1127	ABC transporter
H6CHR_00371	COG2095	MarC family integral membrane protein
H6CHR_00372	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00374	COG0412	Dienelactone hydrolase
H6CHR_00379	COG3411	Ferredoxin
H6CHR_00380	COG2945	thiolester hydrolase activity
H6CHR_00381	COG1686	Belongs to the peptidase S11 family
H6CHR_00382	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H6CHR_00383	COG0049	tRNA binding
H6CHR_00384	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6CHR_00385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H6CHR_00386	COG0051	transcription antitermination factor activity, RNA binding
H6CHR_00389	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H6CHR_00390	COG0088	Forms part of the polypeptide exit tunnel
H6CHR_00391	COG0089	rRNA binding
H6CHR_00392	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H6CHR_00393	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H6CHR_00394	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H6CHR_00395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H6CHR_00396	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H6CHR_00397	COG0255	Belongs to the universal ribosomal protein uL29 family
H6CHR_00398	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H6CHR_00399	COG0678	peroxiredoxin activity
H6CHR_00400	COG0456	acetyltransferase
H6CHR_00402	COG3909	cytochrome
H6CHR_00403	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6CHR_00406	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6CHR_00407	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H6CHR_00411	COG2205	protein histidine kinase activity
H6CHR_00412	COG2130	NADP-dependent
H6CHR_00415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H6CHR_00416	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_00417	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H6CHR_00418	COG0321	lipoyl(octanoyl) transferase activity
H6CHR_00419	COG2921	Belongs to the UPF0250 family
H6CHR_00420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H6CHR_00422	COG0356	it plays a direct role in the translocation of protons across the membrane
H6CHR_00424	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H6CHR_00425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H6CHR_00426	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H6CHR_00427	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H6CHR_00428	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H6CHR_00429	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H6CHR_00431	COG1129	ABC transporter
H6CHR_00432	COG1172	Belongs to the binding-protein-dependent transport system permease family
H6CHR_00433	COG1879	ABC-type sugar transport system periplasmic component
H6CHR_00434	COG0673	inositol 2-dehydrogenase activity
H6CHR_00441	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H6CHR_00441	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H6CHR_00444	COG1793	dna ligase
H6CHR_00444	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H6CHR_00445	COG1793	dna ligase
H6CHR_00446	COG1201	RNA secondary structure unwinding
H6CHR_00458	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6CHR_00459	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6CHR_00460	COG1309	transcriptional regulator
H6CHR_00462	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00463	COG2084	Dehydrogenase
H6CHR_00465	COG0625	glutathione transferase activity
H6CHR_00467	COG4948	Mandelate Racemase Muconate Lactonizing
H6CHR_00470	COG0583	DNA-binding transcription factor activity
H6CHR_00471	COG0277	FAD linked oxidase domain protein
H6CHR_00472	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_00473	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_00474	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H6CHR_00477	COG1228	amidohydrolase
H6CHR_00478	COG0523	cobalamin synthesis protein
H6CHR_00479	COG0583	DNA-binding transcription factor activity
H6CHR_00481	COG4948	Mandelate Racemase Muconate Lactonizing
H6CHR_00485	COG0523	cobalamin synthesis protein
H6CHR_00487	COG1802	Transcriptional regulator
H6CHR_00489	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_00490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H6CHR_00495	COG1942	4-Oxalocrotonate Tautomerase
H6CHR_00496	COG1335	isochorismatase
H6CHR_00499	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6CHR_00503	COG0028	Belongs to the TPP enzyme family
H6CHR_00505	COG3386	PFAM SMP-30 Gluconolaconase
H6CHR_00508	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_00509	COG1879	ABC-type sugar transport system periplasmic component
H6CHR_00510	COG4213	ABC transporter substrate-binding protein
H6CHR_00512	COG4214	carbohydrate transport
H6CHR_00513	COG1129	ABC transporter
H6CHR_00514	COG1172	Belongs to the binding-protein-dependent transport system permease family
H6CHR_00515	COG1172	Belongs to the binding-protein-dependent transport system permease family
H6CHR_00522	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H6CHR_00523	COG0792	nuclease activity
H6CHR_00524	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H6CHR_00526	COG2084	Dehydrogenase
H6CHR_00531	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H6CHR_00535	COG0010	Belongs to the arginase family
H6CHR_00536	COG3639	organic phosphonate transmembrane transporter activity
H6CHR_00537	COG3639	organic phosphonate transmembrane transporter activity
H6CHR_00538	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H6CHR_00539	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H6CHR_00540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H6CHR_00542	COG0709	Synthesizes selenophosphate from selenide and ATP
H6CHR_00545	COG1309	transcriptional regulator
H6CHR_00548	COG2124	cytochrome p450
H6CHR_00548	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H6CHR_00551	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_00552	COG0439	Biotin carboxylase
H6CHR_00555	COG1346	cytolysis
H6CHR_00556	COG1380	Effector of murein hydrolase LrgA
H6CHR_00557	COG0277	FAD linked oxidase domain protein
H6CHR_00565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_00575	COG1473	amidohydrolase
H6CHR_00588	COG0343	queuine tRNA-ribosyltransferase activity
H6CHR_00589	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H6CHR_00590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H6CHR_00592	COG0783	Belongs to the Dps family
H6CHR_00593	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H6CHR_00595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H6CHR_00596	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H6CHR_00597	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H6CHR_00598	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H6CHR_00599	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H6CHR_00600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H6CHR_00601	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H6CHR_00602	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H6CHR_00603	COG1841	ribosomal large subunit assembly
H6CHR_00604	COG0200	Binds to the 23S rRNA
H6CHR_00605	COG0201	protein transport
H6CHR_00606	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H6CHR_00607	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H6CHR_00608	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H6CHR_00609	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H6CHR_00610	COG0202	RNA polymerase activity
H6CHR_00611	COG0203	ribosomal protein L17
H6CHR_00615	COG1960	acyl-CoA dehydrogenase activity
H6CHR_00619	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H6CHR_00622	COG0583	DNA-binding transcription factor activity
H6CHR_00623	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00624	COG0022	dehydrogenase e1 component
H6CHR_00625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H6CHR_00633	COG0693	protein deglycase activity
H6CHR_00641	COG1022	Amp-dependent synthetase and ligase
H6CHR_00642	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_00644	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00649	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H6CHR_00650	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H6CHR_00651	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H6CHR_00652	COG2205	protein histidine kinase activity
H6CHR_00653	COG0745	RESPONSE REGULATOR receiver
H6CHR_00655	COG1187	pseudouridine synthase activity
H6CHR_00656	COG0745	RESPONSE REGULATOR receiver
H6CHR_00667	COG0326	Molecular chaperone. Has ATPase activity
H6CHR_00668	COG2124	cytochrome p450
H6CHR_00669	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H6CHR_00671	COG1764	response to oxidative stress
H6CHR_00672	COG1846	Transcriptional regulator
H6CHR_00674	COG1250	3-hydroxyacyl-CoA dehydrogenase
H6CHR_00675	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H6CHR_00679	COG0584	glycerophosphoryl diester phosphodiesterase
H6CHR_00683	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_00694	COG2268	Band 7 protein
H6CHR_00695	COG5564	TIM-barrel signal transduction protein
H6CHR_00696	COG5441	Belongs to the UPF0261 family
H6CHR_00701	COG1228	amidohydrolase
H6CHR_00702	COG1228	amidohydrolase
H6CHR_00703	COG0596	Alpha beta hydrolase
H6CHR_00704	COG0179	Fumarylacetoacetate (FAA) hydrolase
H6CHR_00710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H6CHR_00711	COG1652	LysM domain
H6CHR_00713	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H6CHR_00724	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H6CHR_00726	COG0640	Transcriptional regulator
H6CHR_00730	COG0583	DNA-binding transcription factor activity
H6CHR_00731	COG1131	(ABC) transporter
H6CHR_00732	COG0842	Transport permease protein
H6CHR_00734	COG2733	membrane
H6CHR_00736	COG1473	amidohydrolase
H6CHR_00739	COG0243	molybdopterin cofactor binding
H6CHR_00757	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H6CHR_00758	COG4106	trans-aconitate 2-methyltransferase activity
H6CHR_00761	COG2076	Multidrug Resistance protein
H6CHR_00763	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H6CHR_00772	COG0463	Glycosyl transferase, family 2
H6CHR_00777	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H6CHR_00779	COG0275	rRNA processing
H6CHR_00780	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H6CHR_00783	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6CHR_00788	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H6CHR_00788	COG0662	Cupin 2, conserved barrel domain protein
H6CHR_00789	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H6CHR_00789	COG2755	lipolytic protein G-D-S-L family
H6CHR_00790	COG1216	Glycosyl transferase, family 2
H6CHR_00790	COG0438	transferase activity, transferring glycosyl groups
H6CHR_00794	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H6CHR_00796	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H6CHR_00797	COG1309	transcriptional regulator
H6CHR_00800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6CHR_00801	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00803	COG4993	Dehydrogenase
H6CHR_00804	COG0628	permease
H6CHR_00807	COG0861	Integral membrane protein TerC family
H6CHR_00810	COG0583	DNA-binding transcription factor activity
H6CHR_00812	COG0277	FAD linked oxidase domain protein
H6CHR_00813	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_00814	COG3186	Phenylalanine-4-hydroxylase
H6CHR_00815	COG2154	pterin-4-alpha-carbinolamine dehydratase
H6CHR_00819	COG0625	glutathione transferase activity
H6CHR_00820	COG2072	flavoprotein involved in K transport
H6CHR_00821	COG0671	phosphoesterase, PA-phosphatase related
H6CHR_00823	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H6CHR_00824	COG5002	protein histidine kinase activity
H6CHR_00825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H6CHR_00826	COG2721	sulfolactate sulfo-lyase activity
H6CHR_00827	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6CHR_00829	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_00830	COG2186	Transcriptional regulator
H6CHR_00831	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00832	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_00833	COG0179	Fumarylacetoacetate (FAA) hydrolase
H6CHR_00837	COG1960	acyl-CoA dehydrogenase activity
H6CHR_00839	COG1250	3-hydroxyacyl-CoA dehydrogenase
H6CHR_00839	COG1024	Enoyl-CoA hydratase
H6CHR_00840	COG0183	Belongs to the thiolase family
H6CHR_00842	COG1024	Enoyl-CoA hydratase
H6CHR_00843	COG1607	acyl-coa hydrolase
H6CHR_00844	COG5265	(ABC) transporter
H6CHR_00845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H6CHR_00847	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_00849	COG0411	ABC transporter
H6CHR_00851	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_00852	COG3473	Maleate cis-trans isomerase
H6CHR_00853	COG0596	Alpha beta hydrolase
H6CHR_00854	COG2309	aminopeptidase activity
H6CHR_00855	COG1335	isochorismatase
H6CHR_00857	COG0583	DNA-binding transcription factor activity
H6CHR_00859	COG0765	amino acid transport
H6CHR_00860	COG0765	amino acid transport
H6CHR_00861	COG1126	abc transporter atp-binding protein
H6CHR_00862	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_00865	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_00866	COG1960	acyl-CoA dehydrogenase activity
H6CHR_00867	COG1960	acyl-CoA dehydrogenase activity
H6CHR_00868	COG0183	Belongs to the thiolase family
H6CHR_00870	COG0583	DNA-binding transcription factor activity
H6CHR_00871	COG0583	DNA-binding transcription factor activity
H6CHR_00872	COG1335	isochorismatase
H6CHR_00874	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H6CHR_00878	COG2003	Belongs to the UPF0758 family
H6CHR_00879	COG0418	dihydroorotase activity
H6CHR_00887	COG1414	Transcriptional regulator
H6CHR_00888	COG0501	Belongs to the peptidase M48B family
H6CHR_00889	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H6CHR_00890	COG4191	Histidine kinase
H6CHR_00891	COG4566	intracellular signal transduction
H6CHR_00892	COG4566	intracellular signal transduction
H6CHR_00894	COG1024	Enoyl-CoA hydratase
H6CHR_00896	COG1187	pseudouridine synthase activity
H6CHR_00897	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6CHR_00898	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_00904	COG0330	HflC and HflK could
H6CHR_00905	COG0598	Magnesium transport protein CorA
H6CHR_00908	COG2807	transmembrane transport
H6CHR_00910	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_00911	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_00916	COG2072	flavoprotein involved in K transport
H6CHR_00918	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H6CHR_00921	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H6CHR_00922	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H6CHR_00923	COG0523	cobalamin synthesis protein
H6CHR_00926	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H6CHR_00927	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H6CHR_00928	COG2001	Belongs to the MraZ family
H6CHR_00929	COG0275	rRNA processing
H6CHR_00930	COG3116	cell division
H6CHR_00932	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H6CHR_00933	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H6CHR_00934	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H6CHR_00935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H6CHR_00936	COG0772	Belongs to the SEDS family
H6CHR_00938	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H6CHR_00939	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H6CHR_00940	COG1181	Belongs to the D-alanine--D-alanine ligase family
H6CHR_00941	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H6CHR_00943	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H6CHR_00944	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H6CHR_00946	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H6CHR_00949	COG1595	DNA-templated transcription, initiation
H6CHR_00953	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H6CHR_00954	COG0575	Belongs to the CDS family
H6CHR_00958	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H6CHR_00961	COG3150	esterase
H6CHR_00962	COG0772	Belongs to the SEDS family
H6CHR_00963	COG0312	modulator of DNA gyrase
H6CHR_00964	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6CHR_00966	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H6CHR_00968	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6CHR_00969	COG0511	ligase activity, forming carbon-carbon bonds
H6CHR_00970	COG0439	Biotin carboxylase
H6CHR_00971	COG2264	protein methyltransferase activity
H6CHR_00973	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6CHR_00975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H6CHR_00982	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H6CHR_00984	COG2204	response regulator
H6CHR_00986	COG2205	protein histidine kinase activity
H6CHR_00987	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6CHR_00989	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6CHR_00990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6CHR_00993	COG2091	lysine biosynthetic process via aminoadipic acid
H6CHR_00998	COG0037	tRNA processing
H6CHR_01000	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_01012	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_01013	COG0583	DNA-binding transcription factor activity
H6CHR_01014	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6CHR_01016	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H6CHR_01017	COG3387	PFAM Glycoside hydrolase 15-related
H6CHR_01019	COG0617	tRNA 3'-terminal CCA addition
H6CHR_01020	COG0625	glutathione transferase activity
H6CHR_01021	COG1285	pathogenesis
H6CHR_01022	COG0741	lytic transglycosylase activity
H6CHR_01022	COG1196	nuclear chromosome segregation
H6CHR_01022	COG0739	heme binding
H6CHR_01023	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H6CHR_01024	COG0583	DNA-binding transcription factor activity
H6CHR_01027	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_01031	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H6CHR_01032	COG1522	sequence-specific DNA binding
H6CHR_01044	COG0583	DNA-binding transcription factor activity
H6CHR_01045	COG2207	Transcriptional regulator
H6CHR_01046	COG3328	transposase activity
H6CHR_01050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H6CHR_01051	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6CHR_01057	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H6CHR_01060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_01062	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H6CHR_01063	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_01067	COG0411	ABC transporter
H6CHR_01069	COG3386	PFAM SMP-30 Gluconolaconase
H6CHR_01072	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_01073	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_01075	COG2301	Belongs to the HpcH HpaI aldolase family
H6CHR_01076	COG1802	Transcriptional regulator
H6CHR_01077	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H6CHR_01082	COG3971	2-oxopent-4-enoate hydratase activity
H6CHR_01084	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_01085	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_01091	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_01095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_01098	COG1021	2,3-dihydroxybenzoate-AMP ligase
H6CHR_01102	COG0179	Fumarylacetoacetate (FAA) hydrolase
H6CHR_01103	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H6CHR_01107	COG4221	oxidoreductase activity
H6CHR_01108	COG0583	DNA-binding transcription factor activity
H6CHR_01111	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H6CHR_01113	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H6CHR_01114	COG0523	cobalamin synthesis protein
H6CHR_01117	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H6CHR_01118	COG2233	PERMEase
H6CHR_01124	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_01126	COG1960	acyl-CoA dehydrogenase activity
H6CHR_01132	COG0583	DNA-binding transcription factor activity
H6CHR_01133	COG2910	NAD(P)H-binding
H6CHR_01135	COG1473	amidohydrolase
H6CHR_01136	COG1522	sequence-specific DNA binding
H6CHR_01137	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H6CHR_01142	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6CHR_01143	COG4166	transmembrane transport
H6CHR_01144	COG0601	transmembrane transport
H6CHR_01145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6CHR_01147	COG0473	3-isopropylmalate dehydrogenase activity
H6CHR_01148	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_01149	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6CHR_01156	COG0154	amidase activity
H6CHR_01158	COG0583	DNA-binding transcription factor activity
H6CHR_01160	COG0346	lactoylglutathione lyase activity
H6CHR_01161	COG0655	NAD(P)H dehydrogenase (quinone) activity
H6CHR_01164	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_01165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6CHR_01167	COG2207	Transcriptional regulator
H6CHR_01168	COG2208	phosphoserine phosphatase activity
H6CHR_01172	COG2172	sigma factor antagonist activity
H6CHR_01181	COG3038	cytochrome b561
H6CHR_01182	COG2814	Major facilitator Superfamily
H6CHR_01183	COG0583	DNA-binding transcription factor activity
H6CHR_01186	COG1640	4-alpha-glucanotransferase
H6CHR_01187	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H6CHR_01189	COG0668	transmembrane transport
H6CHR_01190	COG0366	Alpha amylase catalytic
H6CHR_01191	COG0366	Alpha amylase catalytic
H6CHR_01192	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H6CHR_01196	COG1181	Belongs to the D-alanine--D-alanine ligase family
H6CHR_01196	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H6CHR_01197	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H6CHR_01197	COG0189	ligase activity
H6CHR_01198	COG1132	(ABC) transporter
H6CHR_01200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H6CHR_01201	COG4178	(ABC) transporter
H6CHR_01210	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H6CHR_01217	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H6CHR_01219	COG1765	OsmC-like protein
H6CHR_01220	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H6CHR_01223	COG1473	amidohydrolase
H6CHR_01224	COG4166	transmembrane transport
H6CHR_01225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6CHR_01226	COG0444	Belongs to the ABC transporter superfamily
H6CHR_01227	COG4608	Belongs to the ABC transporter superfamily
H6CHR_01228	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H6CHR_01231	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H6CHR_01232	COG0166	Belongs to the GPI family
H6CHR_01234	COG0459	protein refolding
H6CHR_01235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H6CHR_01236	COG4772	TonB-dependent receptor
H6CHR_01238	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H6CHR_01240	COG1560	Kdo2-lipid A biosynthetic process
H6CHR_01241	COG2267	carboxylic ester hydrolase activity
H6CHR_01242	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H6CHR_01244	COG1333	cytochrome c biogenesis protein
H6CHR_01245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H6CHR_01246	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H6CHR_01247	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H6CHR_01249	COG1965	Belongs to the frataxin family
H6CHR_01256	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H6CHR_01258	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H6CHR_01263	COG0067	glutamate synthase
H6CHR_01263	COG0069	glutamate synthase activity
H6CHR_01263	COG0070	glutamate synthase
H6CHR_01265	COG1127	ABC transporter
H6CHR_01266	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H6CHR_01267	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H6CHR_01268	COG2853	Lipoprotein
H6CHR_01271	COG1131	(ABC) transporter
H6CHR_01272	COG0842	Transport permease protein
H6CHR_01273	COG5007	Belongs to the BolA IbaG family
H6CHR_01274	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H6CHR_01275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H6CHR_01276	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H6CHR_01278	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H6CHR_01279	COG0131	Imidazoleglycerol-phosphate dehydratase
H6CHR_01280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H6CHR_01281	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H6CHR_01284	COG0107	imidazoleglycerol-phosphate synthase activity
H6CHR_01285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H6CHR_01286	COG0140	phosphoribosyl-ATP diphosphatase activity
H6CHR_01288	COG0537	adenosine 5'-monophosphoramidase activity
H6CHR_01289	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H6CHR_01290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H6CHR_01291	COG0805	protein transport
H6CHR_01292	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_01293	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H6CHR_01294	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H6CHR_01295	COG1970	mechanosensitive ion channel activity
H6CHR_01296	COG0723	plastoquinol--plastocyanin reductase activity
H6CHR_01297	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H6CHR_01298	COG2857	Cytochrome c1
H6CHR_01299	COG0625	glutathione transferase activity
H6CHR_01300	COG2969	positive regulation of protein catabolic process
H6CHR_01304	COG0653	protein targeting
H6CHR_01307	COG0494	nUDIX hydrolase
H6CHR_01308	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H6CHR_01309	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H6CHR_01311	COG1696	Membrane protein involved in D-alanine export
H6CHR_01313	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H6CHR_01317	COG0438	transferase activity, transferring glycosyl groups
H6CHR_01320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H6CHR_01324	COG1686	Belongs to the peptidase S11 family
H6CHR_01328	COG0463	Glycosyl transferase, family 2
H6CHR_01329	COG0165	Argininosuccinate lyase
H6CHR_01330	COG3275	phosphorelay sensor kinase activity
H6CHR_01334	COG0477	Major facilitator Superfamily
H6CHR_01338	COG4948	Mandelate Racemase Muconate Lactonizing
H6CHR_01342	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H6CHR_01347	COG0142	geranyltranstransferase activity
H6CHR_01348	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H6CHR_01349	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H6CHR_01350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H6CHR_01351	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H6CHR_01353	COG0494	nUDIX hydrolase
H6CHR_01354	COG0442	prolyl-tRNA aminoacylation
H6CHR_01355	COG0741	lytic transglycosylase activity
H6CHR_01356	COG1253	flavin adenine dinucleotide binding
H6CHR_01357	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H6CHR_01359	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H6CHR_01360	COG2890	protein-(glutamine-N5) methyltransferase activity
H6CHR_01361	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H6CHR_01362	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H6CHR_01364	COG3264	Mechanosensitive ion channel
H6CHR_01364	COG1196	nuclear chromosome segregation
H6CHR_01365	COG0584	glycerophosphoryl diester phosphodiesterase
H6CHR_01366	COG3842	ATPase activity
H6CHR_01367	COG0395	ABC-type sugar transport system, permease component
H6CHR_01368	COG1175	transmembrane transport
H6CHR_01370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6CHR_01374	COG2226	methyltransferase
H6CHR_01377	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H6CHR_01378	COG4145	pantothenate transmembrane transporter activity
H6CHR_01381	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H6CHR_01382	COG0494	nUDIX hydrolase
H6CHR_01383	COG3568	Endonuclease Exonuclease Phosphatase
H6CHR_01384	COG0302	gtp cyclohydrolase
H6CHR_01393	COG4585	Histidine kinase
H6CHR_01394	COG2197	response regulator
H6CHR_01398	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H6CHR_01399	COG0793	Belongs to the peptidase S41A family
H6CHR_01400	COG0588	phosphoglycerate mutase activity
H6CHR_01401	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6CHR_01403	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H6CHR_01404	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H6CHR_01406	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H6CHR_01407	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H6CHR_01408	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H6CHR_01409	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H6CHR_01410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H6CHR_01415	COG0659	secondary active sulfate transmembrane transporter activity
H6CHR_01417	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6CHR_01417	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6CHR_01418	COG3132	Protein of unknown function, DUF480
H6CHR_01419	COG3260	NADH ubiquinone oxidoreductase 20
H6CHR_01420	COG0649	NAD binding
H6CHR_01421	COG0651	ATP synthesis coupled electron transport
H6CHR_01423	COG0650	Formate hydrogenlyase subunit 4
H6CHR_01424	COG0651	ATP synthesis coupled electron transport
H6CHR_01429	COG0489	protein tyrosine kinase activity
H6CHR_01430	COG0583	DNA-binding transcription factor activity
H6CHR_01433	COG3383	formate dehydrogenase (NAD+) activity
H6CHR_01434	COG0463	Glycosyl transferase, family 2
H6CHR_01435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H6CHR_01442	COG3383	formate dehydrogenase (NAD+) activity
H6CHR_01442	COG0243	molybdopterin cofactor binding
H6CHR_01443	COG0437	4 iron, 4 sulfur cluster binding
H6CHR_01447	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H6CHR_01448	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H6CHR_01450	COG0626	cystathionine gamma-synthase activity
H6CHR_01454	COG0247	lactate metabolic process
H6CHR_01455	COG1592	Rubrerythrin
H6CHR_01456	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
H6CHR_01458	COG0765	amino acid transport
H6CHR_01459	COG0765	amino acid transport
H6CHR_01460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6CHR_01463	COG2003	Belongs to the UPF0758 family
H6CHR_01464	COG1047	Peptidyl-prolyl cis-trans
H6CHR_01465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H6CHR_01466	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H6CHR_01468	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H6CHR_01473	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_01474	COG2239	Acts as a magnesium transporter
H6CHR_01475	COG3588	fructose-bisphosphate aldolase
H6CHR_01476	COG2902	Dehydrogenase
H6CHR_01478	COG5002	protein histidine kinase activity
H6CHR_01480	COG0180	Tryptophanyl-tRNA synthetase
H6CHR_01481	COG1994	Peptidase M50
H6CHR_01482	COG0009	L-threonylcarbamoyladenylate synthase
H6CHR_01484	COG0613	PHP domain protein
H6CHR_01493	COG1126	abc transporter atp-binding protein
H6CHR_01496	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6CHR_01501	COG0477	Major facilitator Superfamily
H6CHR_01502	COG0829	nickel cation binding
H6CHR_01504	COG1960	acyl-CoA dehydrogenase activity
H6CHR_01506	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_01507	COG1024	Enoyl-CoA hydratase
H6CHR_01509	COG1024	Enoyl-CoA hydratase
H6CHR_01510	COG1802	Transcriptional regulator
H6CHR_01511	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_01512	COG1960	acyl-CoA dehydrogenase activity
H6CHR_01513	COG1250	3-hydroxyacyl-CoA dehydrogenase
H6CHR_01513	COG1024	Enoyl-CoA hydratase
H6CHR_01514	COG0183	Belongs to the thiolase family
H6CHR_01524	COG1960	acyl-CoA dehydrogenase activity
H6CHR_01525	COG1960	acyl-CoA dehydrogenase activity
H6CHR_01526	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_01533	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_01537	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H6CHR_01544	COG0659	secondary active sulfate transmembrane transporter activity
H6CHR_01549	COG0392	lysyltransferase activity
H6CHR_01552	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_01553	COG1116	anion transmembrane transporter activity
H6CHR_01555	COG0281	malic enzyme
H6CHR_01555	COG0280	phosphate acetyltransferase
H6CHR_01560	COG1477	protein flavinylation
H6CHR_01561	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H6CHR_01563	COG3128	pkhd-type hydroxylase
H6CHR_01565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H6CHR_01569	COG2226	methyltransferase
H6CHR_01572	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H6CHR_01573	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6CHR_01582	COG1953	Uracil, thiamine, allantoin
H6CHR_01583	COG2085	NADP oxidoreductase coenzyme F420-dependent
H6CHR_01586	COG5002	protein histidine kinase activity
H6CHR_01587	COG4133	protoheme IX ABC transporter activity
H6CHR_01597	COG0745	RESPONSE REGULATOR receiver
H6CHR_01598	COG3158	transport of potassium into the cell
H6CHR_01599	COG3158	transport of potassium into the cell
H6CHR_01601	COG0183	Belongs to the thiolase family
H6CHR_01602	COG0427	acetyl-CoA hydrolase
H6CHR_01603	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_01608	COG0183	Belongs to the thiolase family
H6CHR_01620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H6CHR_01621	COG0066	3-isopropylmalate dehydratase activity
H6CHR_01637	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H6CHR_01645	COG0437	4 iron, 4 sulfur cluster binding
H6CHR_01653	COG0028	Belongs to the TPP enzyme family
H6CHR_01654	COG0604	alcohol dehydrogenase
H6CHR_01655	COG1309	transcriptional regulator
H6CHR_01656	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_01657	COG1960	acyl-CoA dehydrogenase activity
H6CHR_01659	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H6CHR_01660	COG1396	sequence-specific DNA binding
H6CHR_01661	COG0235	Class ii aldolase
H6CHR_01665	COG4608	Belongs to the ABC transporter superfamily
H6CHR_01666	COG0444	Belongs to the ABC transporter superfamily
H6CHR_01667	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6CHR_01674	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6CHR_01675	COG0583	DNA-binding transcription factor activity
H6CHR_01676	COG4948	Mandelate Racemase Muconate Lactonizing
H6CHR_01678	COG4521	taurine ABC transporter
H6CHR_01679	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H6CHR_01680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_01681	COG0625	glutathione transferase activity
H6CHR_01683	COG0477	Major facilitator Superfamily
H6CHR_01684	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H6CHR_01685	COG1414	Transcriptional regulator
H6CHR_01690	COG1960	acyl-CoA dehydrogenase activity
H6CHR_01695	COG0583	DNA-binding transcription factor activity
H6CHR_01697	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_01698	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_01705	COG4964	Belongs to the GSP D family
H6CHR_01716	COG2197	response regulator
H6CHR_01720	COG1414	Transcriptional regulator
H6CHR_01723	COG0583	DNA-binding transcription factor activity
H6CHR_01724	COG0243	molybdopterin cofactor binding
H6CHR_01725	COG0437	4 iron, 4 sulfur cluster binding
H6CHR_01726	COG3302	dmso reductase anchor subunit
H6CHR_01730	COG1063	alcohol dehydrogenase
H6CHR_01734	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_01739	COG3634	alkyl hydroperoxide reductase activity
H6CHR_01742	COG0640	Transcriptional regulator
H6CHR_01744	COG2304	oxidoreductase activity
H6CHR_01750	COG1815	bacterial-type flagellum-dependent cell motility
H6CHR_01752	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H6CHR_01753	COG1749	Flagellar hook protein flgE
H6CHR_01756	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H6CHR_01757	COG1706	bacterial-type flagellum-dependent cell motility
H6CHR_01758	COG3951	Flagellar rod assembly protein muramidase FlgJ
H6CHR_01758	COG1705	Flagellar rod assembly protein muramidase FlgJ
H6CHR_01759	COG0840	transmembrane signaling receptor activity
H6CHR_01760	COG0835	chemotaxis
H6CHR_01762	COG0840	transmembrane signaling receptor activity
H6CHR_01764	COG0840	transmembrane signaling receptor activity
H6CHR_01765	COG1256	bacterial-type flagellum assembly
H6CHR_01773	COG2020	methyltransferase activity
H6CHR_01775	COG2267	carboxylic ester hydrolase activity
H6CHR_01786	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_01787	COG0745	RESPONSE REGULATOR receiver
H6CHR_01792	COG1338	Plays a role in the flagellum-specific transport system
H6CHR_01795	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H6CHR_01796	COG1580	Controls the rotational direction of flagella during chemotaxis
H6CHR_01797	COG3144	bacterial-type flagellum assembly
H6CHR_01802	COG1766	The M ring may be actively involved in energy transduction
H6CHR_01803	COG1677	Flagellar hook-basal body complex protein FliE
H6CHR_01805	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H6CHR_01814	COG2198	Histidine kinase
H6CHR_01814	COG0643	Histidine kinase
H6CHR_01815	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H6CHR_01816	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H6CHR_01818	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H6CHR_01821	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H6CHR_01823	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H6CHR_01826	COG1191	sigma factor activity
H6CHR_01829	COG1716	ATPase activity
H6CHR_01831	COG2205	protein histidine kinase activity
H6CHR_01832	COG2197	response regulator
H6CHR_01836	COG4251	negative regulation of phosphorylation
H6CHR_01837	COG4251	negative regulation of phosphorylation
H6CHR_01844	COG4669	(LipO)protein
H6CHR_01859	COG4792	protein secretion
H6CHR_01860	COG4791	protein targeting
H6CHR_01861	COG4794	Type iii secretion
H6CHR_01862	COG4790	Type iii secretion
H6CHR_01872	COG4789	Type iii secretion
H6CHR_01876	COG2197	response regulator
H6CHR_01877	COG0784	Response regulator, receiver
H6CHR_01878	COG2198	Histidine kinase
H6CHR_01878	COG2205	protein histidine kinase activity
H6CHR_01878	COG0784	Response regulator, receiver
H6CHR_01881	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H6CHR_01882	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_01890	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H6CHR_01891	COG0308	aminopeptidase N
H6CHR_01892	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H6CHR_01894	COG0667	Aldo Keto reductase
H6CHR_01895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H6CHR_01896	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H6CHR_01897	COG0251	oxidation-reduction process
H6CHR_01899	COG1666	GTP binding
H6CHR_01900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H6CHR_01901	COG0137	argininosuccinate synthase activity
H6CHR_01902	COG3123	guanosine phosphorylase activity
H6CHR_01904	COG1393	Belongs to the ArsC family
H6CHR_01905	COG0285	dihydrofolate synthase activity
H6CHR_01910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6CHR_01916	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6CHR_01919	COG0028	Belongs to the TPP enzyme family
H6CHR_01920	COG0583	DNA-binding transcription factor activity
H6CHR_01924	COG3604	Transcriptional regulator
H6CHR_01926	COG3118	belongs to the thioredoxin family
H6CHR_01930	COG0492	ferredoxin-NADP+ reductase activity
H6CHR_01931	COG0501	Belongs to the peptidase M48B family
H6CHR_01932	COG4566	intracellular signal transduction
H6CHR_01934	COG2823	Periplasmic or secreted lipoprotein
H6CHR_01936	COG0071	Belongs to the small heat shock protein (HSP20) family
H6CHR_01938	COG0542	response to heat
H6CHR_01939	COG2205	protein histidine kinase activity
H6CHR_01939	COG4191	Histidine kinase
H6CHR_01939	COG0745	RESPONSE REGULATOR receiver
H6CHR_01940	COG1802	Transcriptional regulator
H6CHR_01943	COG2721	sulfolactate sulfo-lyase activity
H6CHR_01945	COG2188	Transcriptional regulator
H6CHR_01946	COG0683	leucine binding
H6CHR_01949	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_01959	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H6CHR_01961	COG2252	PERMEase
H6CHR_01967	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H6CHR_01970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6CHR_01971	COG3287	FIST C domain
H6CHR_01971	COG2200	EAL domain
H6CHR_01971	COG2199	diguanylate cyclase activity
H6CHR_01975	COG0402	S-adenosylhomocysteine deaminase activity
H6CHR_01976	COG0717	Belongs to the dCTP deaminase family
H6CHR_01977	COG2321	neutral zinc metallopeptidase
H6CHR_01978	COG0513	Belongs to the DEAD box helicase family
H6CHR_01979	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H6CHR_01980	COG1253	flavin adenine dinucleotide binding
H6CHR_01985	COG2084	Dehydrogenase
H6CHR_01986	COG3622	Belongs to the hyi family
H6CHR_01987	COG3960	tartronate-semialdehyde synthase activity
H6CHR_01988	COG0583	DNA-binding transcription factor activity
H6CHR_01999	COG2186	Transcriptional regulator
H6CHR_02000	COG1301	dicarboxylic acid transport
H6CHR_02002	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_02003	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6CHR_02006	COG0183	Belongs to the thiolase family
H6CHR_02007	COG1960	acyl-CoA dehydrogenase activity
H6CHR_02011	COG0492	ferredoxin-NADP+ reductase activity
H6CHR_02018	COG3246	L-lysine catabolic process to acetate
H6CHR_02019	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02022	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_02023	COG1917	Cupin 2, conserved barrel domain protein
H6CHR_02023	COG4977	sequence-specific DNA binding
H6CHR_02024	COG1063	alcohol dehydrogenase
H6CHR_02027	COG1063	alcohol dehydrogenase
H6CHR_02028	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H6CHR_02033	COG0511	ligase activity, forming carbon-carbon bonds
H6CHR_02035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H6CHR_02036	COG1984	allophanate hydrolase subunit 2
H6CHR_02038	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H6CHR_02039	COG4221	oxidoreductase activity
H6CHR_02040	COG0765	amino acid transport
H6CHR_02041	COG0765	amino acid transport
H6CHR_02042	COG1126	abc transporter atp-binding protein
H6CHR_02043	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6CHR_02055	COG2860	membrane
H6CHR_02056	COG0129	dihydroxy-acid dehydratase activity
H6CHR_02057	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6CHR_02058	COG2186	Transcriptional regulator
H6CHR_02059	COG3842	ATPase activity
H6CHR_02062	COG3833	ABC-type maltose transport systems, permease component
H6CHR_02064	COG0583	DNA-binding transcription factor activity
H6CHR_02065	COG0251	oxidation-reduction process
H6CHR_02069	COG3842	ATPase activity
H6CHR_02071	COG1176	ABC-type spermidine putrescine transport system, permease component I
H6CHR_02077	COG1793	dna ligase
H6CHR_02078	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6CHR_02083	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H6CHR_02084	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H6CHR_02085	COG2080	2 iron, 2 sulfur cluster binding
H6CHR_02087	COG2814	Major facilitator Superfamily
H6CHR_02088	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H6CHR_02089	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02091	COG0583	DNA-binding transcription factor activity
H6CHR_02093	COG0656	L-ascorbic acid biosynthetic process
H6CHR_02094	COG2233	PERMEase
H6CHR_02098	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02100	COG3754	Rhamnan synthesis protein F
H6CHR_02101	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6CHR_02104	COG2186	Transcriptional regulator
H6CHR_02105	COG2351	hydroxyisourate hydrolase activity
H6CHR_02112	COG1131	(ABC) transporter
H6CHR_02113	COG0842	Transport permease protein
H6CHR_02114	COG0842	Transport permease protein
H6CHR_02125	COG0674	pyruvate-flavodoxin oxidoreductase activity
H6CHR_02125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H6CHR_02130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_02131	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6CHR_02138	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02167	COG1414	Transcriptional regulator
H6CHR_02171	COG1024	Enoyl-CoA hydratase
H6CHR_02174	COG2217	Heavy metal translocating P-type atpase
H6CHR_02175	COG0789	Transcriptional regulator
H6CHR_02176	COG2010	Cytochrome c
H6CHR_02176	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H6CHR_02177	COG2863	cytochrome
H6CHR_02179	COG0697	spore germination
H6CHR_02181	COG2169	Transcriptional regulator
H6CHR_02185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H6CHR_02190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H6CHR_02192	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6CHR_02193	COG1309	transcriptional regulator
H6CHR_02194	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6CHR_02197	COG0527	aspartate kinase activity
H6CHR_02198	COG0667	Aldo Keto reductase
H6CHR_02200	COG0259	pyridoxamine-phosphate oxidase activity
H6CHR_02206	COG0800	Aldolase
H6CHR_02208	COG0346	lactoylglutathione lyase activity
H6CHR_02211	COG1840	ABC-type Fe3 transport system, periplasmic component
H6CHR_02212	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_02213	COG2070	2-Nitropropane dioxygenase
H6CHR_02214	COG4221	oxidoreductase activity
H6CHR_02218	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02221	COG1609	Transcriptional regulator
H6CHR_02222	COG1082	Xylose isomerase domain protein TIM barrel
H6CHR_02223	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_02226	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_02227	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6CHR_02234	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02237	COG0800	Aldolase
H6CHR_02239	COG0129	dihydroxy-acid dehydratase activity
H6CHR_02240	COG2186	Transcriptional regulator
H6CHR_02242	COG1175	transmembrane transport
H6CHR_02244	COG3842	ATPase activity
H6CHR_02245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H6CHR_02247	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02249	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H6CHR_02251	COG0513	Belongs to the DEAD box helicase family
H6CHR_02252	COG0488	(ABC) transporter
H6CHR_02260	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02261	COG0183	Belongs to the thiolase family
H6CHR_02262	COG1960	acyl-CoA dehydrogenase activity
H6CHR_02264	COG1250	3-hydroxyacyl-CoA dehydrogenase
H6CHR_02264	COG1024	Enoyl-CoA hydratase
H6CHR_02265	COG1024	Enoyl-CoA hydratase
H6CHR_02267	COG1960	acyl-CoA dehydrogenase activity
H6CHR_02268	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H6CHR_02275	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_02278	COG1021	2,3-dihydroxybenzoate-AMP ligase
H6CHR_02280	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_02288	COG3191	aminopeptidase activity
H6CHR_02290	COG0789	Transcriptional regulator
H6CHR_02294	COG1764	response to oxidative stress
H6CHR_02295	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_02299	COG1252	NADH dehydrogenase
H6CHR_02300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H6CHR_02301	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H6CHR_02304	COG0589	response to stress
H6CHR_02306	COG2199	diguanylate cyclase activity
H6CHR_02306	COG2200	EAL domain
H6CHR_02306	COG3287	FIST C domain
H6CHR_02310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6CHR_02313	COG0564	pseudouridine synthase activity
H6CHR_02318	COG2354	Protein conserved in bacteria
H6CHR_02319	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H6CHR_02321	COG3468	outer membrane autotransporter barrel domain protein
H6CHR_02326	COG0400	carboxylic ester hydrolase activity
H6CHR_02327	COG2918	glutathione biosynthetic process
H6CHR_02328	COG2423	ornithine cyclodeaminase activity
H6CHR_02330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H6CHR_02332	COG3279	Response regulator of the LytR AlgR family
H6CHR_02333	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H6CHR_02341	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6CHR_02343	COG3279	Response regulator of the LytR AlgR family
H6CHR_02344	COG3275	phosphorelay sensor kinase activity
H6CHR_02348	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6CHR_02356	COG1968	undecaprenyl-diphosphatase activity
H6CHR_02361	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H6CHR_02363	COG3119	arylsulfatase activity
H6CHR_02366	COG1846	Transcriptional regulator
H6CHR_02368	COG0583	DNA-binding transcription factor activity
H6CHR_02370	COG1289	transmembrane transporter activity
H6CHR_02373	COG1045	serine acetyltransferase
H6CHR_02374	COG0521	Mo-molybdopterin cofactor biosynthetic process
H6CHR_02375	COG3028	Belongs to the UPF0307 family
H6CHR_02376	COG0312	modulator of DNA gyrase
H6CHR_02378	COG0494	nUDIX hydrolase
H6CHR_02379	COG1610	YqeY-like protein
H6CHR_02380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H6CHR_02381	COG2081	HI0933 family
H6CHR_02384	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H6CHR_02385	COG0243	molybdopterin cofactor binding
H6CHR_02387	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H6CHR_02389	COG2223	nitrite transmembrane transporter activity
H6CHR_02391	COG1116	anion transmembrane transporter activity
H6CHR_02392	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_02393	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H6CHR_02394	COG3707	response regulator
H6CHR_02395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H6CHR_02398	COG0683	leucine binding
H6CHR_02399	COG0436	Aminotransferase
H6CHR_02400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H6CHR_02401	COG1185	polyribonucleotide nucleotidyltransferase activity
H6CHR_02403	COG0149	triose-phosphate isomerase activity
H6CHR_02406	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H6CHR_02407	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H6CHR_02408	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H6CHR_02409	COG0649	NAD binding
H6CHR_02412	COG1034	ATP synthesis coupled electron transport
H6CHR_02413	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H6CHR_02414	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H6CHR_02416	COG0713	ATP synthesis coupled electron transport
H6CHR_02419	COG1007	ATP synthesis coupled electron transport
H6CHR_02421	COG0494	nUDIX hydrolase
H6CHR_02423	COG0583	DNA-binding transcription factor activity
H6CHR_02427	COG4336	lyase activity
H6CHR_02432	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_02433	COG0028	Belongs to the TPP enzyme family
H6CHR_02437	COG0583	DNA-binding transcription factor activity
H6CHR_02438	COG1132	(ABC) transporter
H6CHR_02439	COG1846	Transcriptional regulator
H6CHR_02441	COG1566	PFAM secretion protein HlyD family protein
H6CHR_02442	COG2814	Major facilitator Superfamily
H6CHR_02450	COG0724	RNA recognition motif
H6CHR_02452	COG0583	DNA-binding transcription factor activity
H6CHR_02453	COG1802	Transcriptional regulator
H6CHR_02459	COG0154	amidase activity
H6CHR_02461	COG0477	Major facilitator Superfamily
H6CHR_02463	COG1215	transferase activity, transferring glycosyl groups
H6CHR_02471	COG3795	YCII-related domain
H6CHR_02472	COG0154	amidase activity
H6CHR_02475	COG2186	Transcriptional regulator
H6CHR_02478	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_02480	COG0366	Alpha amylase catalytic
H6CHR_02484	COG4178	(ABC) transporter
H6CHR_02486	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02488	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02489	COG0583	DNA-binding transcription factor activity
H6CHR_02490	COG1136	(ABC) transporter
H6CHR_02491	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H6CHR_02493	COG1850	ribulose-bisphosphate carboxylase activity
H6CHR_02495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6CHR_02496	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_02497	COG1609	Transcriptional regulator
H6CHR_02499	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H6CHR_02500	COG0586	Pfam SNARE associated Golgi protein
H6CHR_02503	COG0860	N-Acetylmuramoyl-L-alanine amidase
H6CHR_02504	COG0802	atpase or kinase
H6CHR_02505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H6CHR_02508	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02509	COG4974	Belongs to the 'phage' integrase family
H6CHR_02511	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02512	COG2833	Protein of unknown function (DUF455)
H6CHR_02514	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H6CHR_02517	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H6CHR_02518	COG0148	phosphopyruvate hydratase activity
H6CHR_02519	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H6CHR_02520	COG0504	CTP synthase activity
H6CHR_02521	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H6CHR_02523	COG0756	dUTP diphosphatase activity
H6CHR_02525	COG1047	Peptidyl-prolyl cis-trans
H6CHR_02526	COG2850	peptidyl-arginine hydroxylation
H6CHR_02529	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H6CHR_02530	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H6CHR_02531	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6CHR_02538	COG0741	lytic transglycosylase activity
H6CHR_02542	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_02549	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6CHR_02551	COG0411	ABC transporter
H6CHR_02558	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H6CHR_02560	COG0765	amino acid transport
H6CHR_02563	COG1126	abc transporter atp-binding protein
H6CHR_02565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6CHR_02567	COG1609	Transcriptional regulator
H6CHR_02571	COG5654	RES domain protein
H6CHR_02572	COG1522	sequence-specific DNA binding
H6CHR_02574	COG1305	Transglutaminase-like
H6CHR_02578	COG2308	Evidence 4 Homologs of previously reported genes of
H6CHR_02582	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H6CHR_02585	COG3842	ATPase activity
H6CHR_02586	COG3842	ATPase activity
H6CHR_02589	COG0395	ABC-type sugar transport system, permease component
H6CHR_02593	COG2951	lytic endotransglycosylase activity
H6CHR_02596	COG0714	Associated with various cellular activities
H6CHR_02598	COG1511	domain protein
H6CHR_02598	COG3264	Mechanosensitive ion channel
H6CHR_02601	COG1960	acyl-CoA dehydrogenase activity
H6CHR_02605	COG1294	oxidase, subunit
H6CHR_02606	COG1271	oxidase subunit
H6CHR_02608	COG4251	negative regulation of phosphorylation
H6CHR_02609	COG0784	Response regulator, receiver
H6CHR_02610	COG0784	Response regulator, receiver
H6CHR_02610	COG4191	Histidine kinase
H6CHR_02612	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H6CHR_02613	COG2814	Major facilitator Superfamily
H6CHR_02614	COG0477	Major facilitator Superfamily
H6CHR_02616	COG1414	Transcriptional regulator
H6CHR_02617	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H6CHR_02619	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H6CHR_02628	COG0477	Major facilitator Superfamily
H6CHR_02632	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H6CHR_02634	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H6CHR_02634	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H6CHR_02635	COG0509	glycine decarboxylation via glycine cleavage system
H6CHR_02636	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H6CHR_02641	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_02642	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6CHR_02649	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02653	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02656	COG0642	Histidine kinase
H6CHR_02657	COG0745	RESPONSE REGULATOR receiver
H6CHR_02659	COG2194	sulfuric ester hydrolase activity
H6CHR_02662	COG4302	ethanolamine ammonia-lyase activity
H6CHR_02663	COG4303	Ethanolamine ammonia lyase large subunit
H6CHR_02664	COG0545	Peptidyl-prolyl cis-trans isomerase
H6CHR_02665	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H6CHR_02666	COG2169	Transcriptional regulator
H6CHR_02666	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H6CHR_02668	COG3145	DNA-N1-methyladenine dioxygenase activity
H6CHR_02671	COG0583	DNA-binding transcription factor activity
H6CHR_02684	COG1024	Enoyl-CoA hydratase
H6CHR_02686	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6CHR_02692	COG2909	trisaccharide binding
H6CHR_02692	COG2909	trisaccharide binding
H6CHR_02694	COG2909	trisaccharide binding
H6CHR_02694	COG2909	trisaccharide binding
H6CHR_02695	COG2909	trisaccharide binding
H6CHR_02697	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_02698	COG1183	phosphatidylcholine synthase activity
H6CHR_02699	COG1160	GTP binding
H6CHR_02701	COG1132	(ABC) transporter
H6CHR_02702	COG3384	dioxygenase
H6CHR_02707	COG0587	DNA-directed DNA polymerase activity
H6CHR_02711	COG1309	transcriptional regulator
H6CHR_02713	COG2274	protein secretion by the type I secretion system
H6CHR_02725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H6CHR_02728	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_02729	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_02733	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02736	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H6CHR_02737	COG0045	succinate-CoA ligase (ADP-forming) activity
H6CHR_02738	COG1024	Enoyl-CoA hydratase
H6CHR_02742	COG2130	NADP-dependent
H6CHR_02743	COG1960	acyl-CoA dehydrogenase activity
H6CHR_02745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_02746	COG2070	2-Nitropropane dioxygenase
H6CHR_02747	COG2188	Transcriptional regulator
H6CHR_02750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H6CHR_02758	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H6CHR_02759	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H6CHR_02761	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6CHR_02762	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H6CHR_02765	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_02766	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_02768	COG2267	carboxylic ester hydrolase activity
H6CHR_02769	COG1414	Transcriptional regulator
H6CHR_02771	COG0028	Belongs to the TPP enzyme family
H6CHR_02772	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H6CHR_02773	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_02776	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_02781	COG1487	ribonuclease activity
H6CHR_02788	COG1024	Enoyl-CoA hydratase
H6CHR_02789	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_02790	COG1024	Enoyl-CoA hydratase
H6CHR_02791	COG2249	NAD(P)H dehydrogenase (quinone) activity
H6CHR_02793	COG4191	Histidine kinase
H6CHR_02793	COG0784	Response regulator, receiver
H6CHR_02797	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6CHR_02797	COG0045	succinate-CoA ligase (ADP-forming) activity
H6CHR_02797	COG1042	CoA-binding domain protein
H6CHR_02798	COG2176	DNA-directed DNA polymerase activity
H6CHR_02798	COG5002	protein histidine kinase activity
H6CHR_02799	COG0745	RESPONSE REGULATOR receiver
H6CHR_02803	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6CHR_02804	COG3162	membrane
H6CHR_02808	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H6CHR_02810	COG3850	Histidine kinase
H6CHR_02814	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H6CHR_02815	COG1140	nitrate reductase beta subunit
H6CHR_02816	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H6CHR_02817	COG2181	nitrate reductase activity
H6CHR_02818	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6CHR_02826	COG2010	Cytochrome c
H6CHR_02826	COG4993	Dehydrogenase
H6CHR_02832	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_02838	COG3278	Belongs to the heme-copper respiratory oxidase family
H6CHR_02845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_02848	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_02850	COG0589	response to stress
H6CHR_02855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_02857	COG0084	hydrolase, TatD family'
H6CHR_02860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H6CHR_02861	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H6CHR_02863	COG2879	small protein
H6CHR_02864	COG1966	Carbon starvation protein
H6CHR_02875	COG2183	response to ionizing radiation
H6CHR_02876	COG0583	DNA-binding transcription factor activity
H6CHR_02879	COG2271	Major facilitator Superfamily
H6CHR_02881	COG0534	Mate efflux family protein
H6CHR_02892	COG0477	Major facilitator Superfamily
H6CHR_02893	COG2814	Major facilitator Superfamily
H6CHR_02894	COG2814	Major facilitator Superfamily
H6CHR_02897	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H6CHR_02897	COG3008	intermembrane lipid transfer
H6CHR_02898	COG2995	paraquat-inducible protein a
H6CHR_02899	COG2995	paraquat-inducible protein a
H6CHR_02900	COG0583	DNA-binding transcription factor activity
H6CHR_02901	COG2814	Major facilitator Superfamily
H6CHR_02902	COG0667	Aldo Keto reductase
H6CHR_02903	COG0745	RESPONSE REGULATOR receiver
H6CHR_02904	COG0642	Histidine kinase
H6CHR_02906	COG2233	PERMEase
H6CHR_02907	COG5507	3-demethylubiquinone-9 3-methyltransferase
H6CHR_02911	COG1960	acyl-CoA dehydrogenase activity
H6CHR_02912	COG2130	NADP-dependent
H6CHR_02916	COG1960	acyl-CoA dehydrogenase activity
H6CHR_02917	COG0183	Belongs to the thiolase family
H6CHR_02918	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6CHR_02919	COG1024	Enoyl-CoA hydratase
H6CHR_02919	COG1250	3-hydroxyacyl-CoA dehydrogenase
H6CHR_02921	COG0411	ABC transporter
H6CHR_02923	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_02925	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_02926	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H6CHR_02927	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H6CHR_02928	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6CHR_02929	COG2917	probably involved in intracellular septation
H6CHR_02931	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6CHR_02932	COG0047	phosphoribosylformylglycinamidine synthase activity
H6CHR_02932	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H6CHR_02933	COG0024	Methionine aminopeptidase
H6CHR_02934	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H6CHR_02935	COG2259	Doxx family
H6CHR_02936	COG0242	peptide deformylase activity
H6CHR_02938	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H6CHR_02940	COG1196	nuclear chromosome segregation
H6CHR_02953	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H6CHR_02954	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H6CHR_02955	COG4208	sulfate ABC transporter
H6CHR_02957	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H6CHR_02960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H6CHR_02962	COG1045	serine acetyltransferase
H6CHR_02963	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H6CHR_02964	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H6CHR_02965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H6CHR_02965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6CHR_02968	COG0583	DNA-binding transcription factor activity
H6CHR_02970	COG1272	protein, Hemolysin III
H6CHR_02977	COG2895	sulfate adenylyltransferase (ATP) activity
H6CHR_02978	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H6CHR_02979	COG0492	ferredoxin-NADP+ reductase activity
H6CHR_02980	COG0671	phosphoesterase, PA-phosphatase related
H6CHR_02982	COG4654	Cytochrome c, class I
H6CHR_02984	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H6CHR_02986	COG0114	fumarate hydratase activity
H6CHR_02988	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H6CHR_02995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H6CHR_02996	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H6CHR_02997	COG0740	serine-type endopeptidase activity
H6CHR_02998	COG0544	peptidyl-prolyl cis-trans isomerase activity
H6CHR_03001	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6CHR_03002	COG1562	ergosterol biosynthetic process
H6CHR_03004	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H6CHR_03012	COG1011	Hydrolase
H6CHR_03013	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H6CHR_03019	COG1137	ATPase activity
H6CHR_03021	COG2204	response regulator
H6CHR_03029	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H6CHR_03031	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_03032	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H6CHR_03033	COG0583	DNA-binding transcription factor activity
H6CHR_03035	COG1024	Enoyl-CoA hydratase
H6CHR_03037	COG1960	acyl-CoA dehydrogenase activity
H6CHR_03040	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03045	COG3268	Saccharopine dehydrogenase
H6CHR_03046	COG0142	geranyltranstransferase activity
H6CHR_03048	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H6CHR_03050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_03054	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_03056	COG0642	Histidine kinase
H6CHR_03058	COG2326	polyphosphate kinase activity
H6CHR_03077	COG0582	viral genome integration into host DNA
H6CHR_03080	COG0037	tRNA processing
H6CHR_03081	COG0825	malonyl-CoA metabolic process
H6CHR_03083	COG0215	cysteine-tRNA ligase activity
H6CHR_03087	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6CHR_03088	COG3228	Belongs to the MtfA family
H6CHR_03091	COG0741	lytic transglycosylase activity
H6CHR_03092	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H6CHR_03093	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H6CHR_03099	COG4968	Prepilin-type N-terminal cleavage methylation domain
H6CHR_03100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H6CHR_03100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H6CHR_03103	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H6CHR_03104	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6CHR_03105	COG0436	Aminotransferase
H6CHR_03106	COG0824	Thioesterase
H6CHR_03108	COG0848	biopolymer transport protein
H6CHR_03113	COG1741	Belongs to the pirin family
H6CHR_03115	COG2259	Doxx family
H6CHR_03116	COG1741	Belongs to the pirin family
H6CHR_03119	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6CHR_03120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H6CHR_03123	COG3210	domain, Protein
H6CHR_03124	COG2831	hemolysin activation secretion protein
H6CHR_03127	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H6CHR_03129	COG0840	transmembrane signaling receptor activity
H6CHR_03133	COG1619	proteins homologs of microcin C7 resistance protein MccF
H6CHR_03139	COG4566	intracellular signal transduction
H6CHR_03140	COG4191	Histidine kinase
H6CHR_03141	COG2197	response regulator
H6CHR_03144	COG0477	Major facilitator Superfamily
H6CHR_03145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H6CHR_03146	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H6CHR_03147	COG1845	cytochrome c oxidase, subunit III
H6CHR_03148	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H6CHR_03151	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H6CHR_03152	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H6CHR_03154	COG1840	ABC-type Fe3 transport system, periplasmic component
H6CHR_03156	COG3842	ATPase activity
H6CHR_03157	COG1672	PFAM Archaeal ATPase
H6CHR_03157	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H6CHR_03158	COG0519	Catalyzes the synthesis of GMP from XMP
H6CHR_03158	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H6CHR_03162	COG2867	negative regulation of translational initiation
H6CHR_03163	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H6CHR_03171	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H6CHR_03172	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H6CHR_03173	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H6CHR_03174	COG0195	Participates in both transcription termination and antitermination
H6CHR_03174	COG2251	uridine kinase activity
H6CHR_03175	COG0779	Required for maturation of 30S ribosomal subunits
H6CHR_03176	COG0477	Major facilitator Superfamily
H6CHR_03177	COG4172	Belongs to the ABC transporter superfamily
H6CHR_03178	COG4239	(ABC) transporter, permease
H6CHR_03179	COG4174	ABC transporter (Permease)
H6CHR_03182	COG1793	dna ligase
H6CHR_03183	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H6CHR_03185	COG1982	Orn Lys Arg decarboxylase major
H6CHR_03214	COG0582	viral genome integration into host DNA
H6CHR_03219	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H6CHR_03223	COG0583	DNA-binding transcription factor activity
H6CHR_03224	COG0436	Aminotransferase
H6CHR_03226	COG1643	Atp-dependent helicase
H6CHR_03227	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H6CHR_03227	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H6CHR_03228	COG0436	Aminotransferase
H6CHR_03229	COG2171	N-acyltransferase activity
H6CHR_03231	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6CHR_03232	COG2890	protein-(glutamine-N5) methyltransferase activity
H6CHR_03233	COG0488	(ABC) transporter
H6CHR_03256	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H6CHR_03258	COG2885	chlorophyll binding
H6CHR_03259	COG0823	Involved in the tonB-independent uptake of proteins
H6CHR_03260	COG1132	(ABC) transporter
H6CHR_03261	COG1530	ribonuclease E activity
H6CHR_03262	COG0424	maF-like protein
H6CHR_03263	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H6CHR_03264	COG0799	negative regulation of ribosome biogenesis
H6CHR_03265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H6CHR_03266	COG0408	coproporphyrinogen oxidase activity
H6CHR_03267	COG0151	Belongs to the GarS family
H6CHR_03268	COG0217	transcriptional regulatory protein
H6CHR_03277	COG4245	von Willebrand factor, type A
H6CHR_03280	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03287	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H6CHR_03290	COG0433	COG0433 Predicted ATPase
H6CHR_03292	COG1595	DNA-templated transcription, initiation
H6CHR_03294	COG3220	belongs to the UPF0276 family
H6CHR_03299	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H6CHR_03300	COG1744	ABC transporter substrate-binding protein PnrA-like
H6CHR_03304	COG0402	S-adenosylhomocysteine deaminase activity
H6CHR_03305	COG2925	Exonuclease
H6CHR_03306	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_03307	COG0542	response to heat
H6CHR_03308	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H6CHR_03312	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H6CHR_03313	COG1570	exodeoxyribonuclease VII activity
H6CHR_03314	COG0811	peptide transport
H6CHR_03315	COG0848	biopolymer transport protein
H6CHR_03316	COG1663	tetraacyldisaccharide 4'-kinase activity
H6CHR_03317	COG2835	tetraacyldisaccharide 4'-kinase activity
H6CHR_03318	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H6CHR_03319	COG0563	adenylate kinase activity
H6CHR_03322	COG0252	asparaginase activity
H6CHR_03323	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H6CHR_03325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6CHR_03326	COG2814	Major facilitator Superfamily
H6CHR_03328	COG1250	3-hydroxyacyl-CoA dehydrogenase
H6CHR_03329	COG1024	Enoyl-CoA hydratase
H6CHR_03333	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6CHR_03335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6CHR_03336	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H6CHR_03340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H6CHR_03342	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H6CHR_03343	COG0505	Belongs to the CarA family
H6CHR_03344	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6CHR_03345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H6CHR_03346	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6CHR_03347	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6CHR_03348	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H6CHR_03349	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6CHR_03352	COG0750	zinc metalloprotease
H6CHR_03353	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H6CHR_03354	COG0575	Belongs to the CDS family
H6CHR_03355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H6CHR_03356	COG0233	cytoplasmic translational termination
H6CHR_03357	COG0528	UMP kinase activity
H6CHR_03358	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H6CHR_03359	COG0052	Belongs to the universal ribosomal protein uS2 family
H6CHR_03361	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6CHR_03362	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H6CHR_03363	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03364	COG0557	exoribonuclease II activity
H6CHR_03366	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6CHR_03367	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H6CHR_03370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H6CHR_03371	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03374	COG0745	RESPONSE REGULATOR receiver
H6CHR_03375	COG2205	protein histidine kinase activity
H6CHR_03376	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H6CHR_03376	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H6CHR_03377	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H6CHR_03377	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H6CHR_03378	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H6CHR_03379	COG0560	Phosphoserine phosphatase
H6CHR_03380	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_03384	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6CHR_03385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H6CHR_03386	COG3038	cytochrome b561
H6CHR_03388	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H6CHR_03389	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H6CHR_03390	COG1492	cobalamin metabolic process
H6CHR_03393	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6CHR_03398	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H6CHR_03399	COG1120	ATPase activity
H6CHR_03401	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H6CHR_03403	COG4206	TonB-dependent receptor
H6CHR_03407	COG0730	response to heat
H6CHR_03410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H6CHR_03411	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_03415	COG1802	Transcriptional regulator
H6CHR_03416	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H6CHR_03417	COG0583	DNA-binding transcription factor activity
H6CHR_03418	COG0129	dihydroxy-acid dehydratase activity
H6CHR_03420	COG0351	phosphomethylpyrimidine kinase
H6CHR_03423	COG2022	thiamine diphosphate biosynthetic process
H6CHR_03426	COG3657	addiction module killer protein
H6CHR_03427	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H6CHR_03429	COG0484	heat shock protein binding
H6CHR_03438	COG1175	transmembrane transport
H6CHR_03441	COG0246	Mannitol dehydrogenase
H6CHR_03443	COG2207	Transcriptional regulator
H6CHR_03443	COG4753	response regulator
H6CHR_03444	COG1070	Carbohydrate kinase
H6CHR_03447	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_03448	COG0642	Histidine kinase
H6CHR_03449	COG0745	RESPONSE REGULATOR receiver
H6CHR_03450	COG1414	Transcriptional regulator
H6CHR_03453	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H6CHR_03454	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H6CHR_03455	COG1414	Transcriptional regulator
H6CHR_03457	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6CHR_03458	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6CHR_03459	COG1183	phosphatidylcholine synthase activity
H6CHR_03460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H6CHR_03461	COG0440	acetolactate synthase activity
H6CHR_03462	COG0028	Belongs to the TPP enzyme family
H6CHR_03467	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H6CHR_03469	COG0347	Belongs to the P(II) protein family
H6CHR_03470	COG0697	spore germination
H6CHR_03472	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H6CHR_03477	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_03479	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_03481	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H6CHR_03483	COG0589	response to stress
H6CHR_03484	COG3243	poly(R)-hydroxyalkanoic acid synthase
H6CHR_03487	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03490	COG0745	RESPONSE REGULATOR receiver
H6CHR_03493	COG2207	Transcriptional regulator
H6CHR_03494	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03496	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H6CHR_03500	COG0542	response to heat
H6CHR_03505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H6CHR_03506	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H6CHR_03512	COG0589	response to stress
H6CHR_03513	COG0071	Belongs to the small heat shock protein (HSP20) family
H6CHR_03517	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H6CHR_03521	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_03523	COG3321	synthase
H6CHR_03523	COG0604	alcohol dehydrogenase
H6CHR_03523	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03526	COG0179	Fumarylacetoacetate (FAA) hydrolase
H6CHR_03528	COG1802	Transcriptional regulator
H6CHR_03530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H6CHR_03531	COG3954	Phosphoribulokinase
H6CHR_03532	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H6CHR_03534	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H6CHR_03536	COG0464	growth
H6CHR_03537	COG4451	ribulose bisphosphate carboxylase, small
H6CHR_03538	COG1850	ribulose-bisphosphate carboxylase activity
H6CHR_03545	COG1131	(ABC) transporter
H6CHR_03547	COG2010	Cytochrome c
H6CHR_03551	COG0714	Associated with various cellular activities
H6CHR_03558	COG0535	radical SAM domain protein
H6CHR_03560	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H6CHR_03561	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H6CHR_03564	COG3851	Histidine kinase
H6CHR_03565	COG2197	response regulator
H6CHR_03568	COG0512	Glutamine amidotransferase of anthranilate synthase
H6CHR_03568	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H6CHR_03570	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
H6CHR_03571	COG1229	Formylmethanofuran dehydrogenase subunit A
H6CHR_03573	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H6CHR_03581	COG3284	Transcriptional regulator
H6CHR_03583	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
H6CHR_03585	COG0189	ligase activity
H6CHR_03586	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
H6CHR_03588	COG0702	epimerase
H6CHR_03591	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H6CHR_03592	COG0746	molybdenum cofactor guanylyltransferase activity
H6CHR_03593	COG0303	'Molybdopterin
H6CHR_03595	COG0328	RNA-DNA hybrid ribonuclease activity
H6CHR_03597	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6CHR_03598	COG0741	lytic transglycosylase activity
H6CHR_03598	COG1388	LysM domain
H6CHR_03599	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_03601	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H6CHR_03603	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H6CHR_03604	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H6CHR_03605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H6CHR_03610	COG0431	NADPH-dependent FMN reductase
H6CHR_03611	COG0798	PFAM Bile acid sodium symporter
H6CHR_03612	COG0640	Transcriptional regulator
H6CHR_03615	COG0640	Transcriptional regulator
H6CHR_03621	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6CHR_03621	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6CHR_03627	COG1074	ATP-dependent DNA helicase activity
H6CHR_03629	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H6CHR_03630	COG0673	inositol 2-dehydrogenase activity
H6CHR_03631	COG0254	rRNA binding
H6CHR_03633	COG0534	Mate efflux family protein
H6CHR_03634	COG5002	protein histidine kinase activity
H6CHR_03637	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H6CHR_03638	COG0581	inorganic phosphate transmembrane transporter activity
H6CHR_03639	COG0573	inorganic phosphate transmembrane transporter activity
H6CHR_03640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H6CHR_03645	COG3634	alkyl hydroperoxide reductase activity
H6CHR_03646	COG0625	glutathione transferase activity
H6CHR_03655	COG1042	CoA-binding domain protein
H6CHR_03655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6CHR_03655	COG0045	succinate-CoA ligase (ADP-forming) activity
H6CHR_03656	COG2030	dehydratase
H6CHR_03657	COG1024	Enoyl-CoA hydratase
H6CHR_03658	COG1960	acyl-CoA dehydrogenase activity
H6CHR_03659	COG1960	acyl-CoA dehydrogenase activity
H6CHR_03661	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03665	COG1024	Enoyl-CoA hydratase
H6CHR_03666	COG2186	Transcriptional regulator
H6CHR_03668	COG0667	Aldo Keto reductase
H6CHR_03670	COG1960	acyl-CoA dehydrogenase activity
H6CHR_03673	COG2072	flavoprotein involved in K transport
H6CHR_03675	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03677	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03679	COG1024	Enoyl-CoA hydratase
H6CHR_03680	COG2070	2-Nitropropane dioxygenase
H6CHR_03683	COG4670	ketone body catabolic process
H6CHR_03685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H6CHR_03689	COG2072	flavoprotein involved in K transport
H6CHR_03691	COG1053	succinate dehydrogenase
H6CHR_03692	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H6CHR_03693	COG1053	succinate dehydrogenase
H6CHR_03705	COG3618	amidohydrolase
H6CHR_03707	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_03708	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03711	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_03712	COG2186	Transcriptional regulator
H6CHR_03716	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H6CHR_03719	COG0183	Belongs to the thiolase family
H6CHR_03722	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_03724	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_03727	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_03729	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_03730	COG1716	ATPase activity
H6CHR_03731	COG1053	succinate dehydrogenase
H6CHR_03732	COG2084	Dehydrogenase
H6CHR_03735	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H6CHR_03738	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03749	COG2828	Protein conserved in bacteria
H6CHR_03751	COG0583	DNA-binding transcription factor activity
H6CHR_03752	COG1301	dicarboxylic acid transport
H6CHR_03756	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H6CHR_03758	COG2814	Major facilitator Superfamily
H6CHR_03761	COG1902	pentaerythritol trinitrate reductase activity
H6CHR_03762	COG0697	spore germination
H6CHR_03763	COG0477	Major facilitator Superfamily
H6CHR_03770	COG1053	succinate dehydrogenase
H6CHR_03772	COG2982	Protein involved in outer membrane biogenesis
H6CHR_03777	COG1024	Enoyl-CoA hydratase
H6CHR_03779	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03783	COG0589	response to stress
H6CHR_03786	COG0456	acetyltransferase
H6CHR_03786	COG1846	Transcriptional regulator
H6CHR_03787	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03791	COG1295	ribonuclease BN
H6CHR_03794	COG0667	Aldo Keto reductase
H6CHR_03799	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6CHR_03800	COG1136	(ABC) transporter
H6CHR_03803	COG0626	cystathionine gamma-synthase activity
H6CHR_03805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H6CHR_03806	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H6CHR_03808	COG0330	HflC and HflK could
H6CHR_03809	COG0330	HflC and HflK could
H6CHR_03810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H6CHR_03811	COG1923	regulation of RNA biosynthetic process
H6CHR_03812	COG1160	GTP binding
H6CHR_03813	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6CHR_03815	COG0124	histidyl-tRNA synthetase
H6CHR_03816	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H6CHR_03819	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H6CHR_03820	COG0105	UTP biosynthetic process
H6CHR_03821	COG1187	pseudouridine synthase activity
H6CHR_03822	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H6CHR_03823	COG0564	pseudouridine synthase activity
H6CHR_03825	COG1199	ATP-dependent helicase activity
H6CHR_03829	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H6CHR_03830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6CHR_03831	COG0508	dehydrogenase complex catalyzes the overall conversion of
H6CHR_03832	COG0567	Dehydrogenase, E1 component
H6CHR_03836	COG3604	Transcriptional regulator
H6CHR_03840	COG1360	Flagellar Motor Protein
H6CHR_03844	COG0473	3-isopropylmalate dehydrogenase activity
H6CHR_03845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6CHR_03847	COG2133	pyrroloquinoline quinone binding
H6CHR_03848	COG0791	NLP P60 protein
H6CHR_03849	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6CHR_03850	COG0508	dehydrogenase complex catalyzes the overall conversion of
H6CHR_03851	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H6CHR_03852	COG4191	Histidine kinase
H6CHR_03853	COG4566	intracellular signal transduction
H6CHR_03854	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H6CHR_03855	COG0339	signal peptide processing
H6CHR_03857	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H6CHR_03858	COG0167	dihydroorotate dehydrogenase activity
H6CHR_03861	COG0579	oxidoreductase
H6CHR_03866	COG0443	Heat shock 70 kDa protein
H6CHR_03867	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H6CHR_03869	COG0822	iron-sulfur transferase activity
H6CHR_03870	COG1104	cysteine desulfurase activity
H6CHR_03871	COG1959	2 iron, 2 sulfur cluster binding
H6CHR_03872	COG0556	nucleotide-excision repair
H6CHR_03875	COG2878	Part of a membrane complex involved in electron transport
H6CHR_03878	COG4770	biotin carboxylase activity
H6CHR_03879	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H6CHR_03880	COG1703	isobutyryl-CoA mutase activity
H6CHR_03881	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H6CHR_03881	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H6CHR_03882	COG1802	Transcriptional regulator
H6CHR_03886	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H6CHR_03887	COG1201	RNA secondary structure unwinding
H6CHR_03888	COG0745	RESPONSE REGULATOR receiver
H6CHR_03895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H6CHR_03895	COG4651	solute:proton antiporter activity
H6CHR_03896	COG1301	dicarboxylic acid transport
H6CHR_03897	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_03901	COG1960	acyl-CoA dehydrogenase activity
H6CHR_03902	COG0583	DNA-binding transcription factor activity
H6CHR_03903	COG0183	Belongs to the thiolase family
H6CHR_03904	COG3243	poly(R)-hydroxyalkanoic acid synthase
H6CHR_03910	COG3045	CreA protein
H6CHR_03912	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_03915	COG0583	DNA-binding transcription factor activity
H6CHR_03916	COG3622	Belongs to the hyi family
H6CHR_03923	COG0183	Belongs to the thiolase family
H6CHR_03926	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_03932	COG0235	Class ii aldolase
H6CHR_03934	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_03938	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H6CHR_03945	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_03947	COG0583	DNA-binding transcription factor activity
H6CHR_03949	COG1024	Enoyl-CoA hydratase
H6CHR_03953	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H6CHR_03960	COG0270	DNA (cytosine-5-)-methyltransferase activity
H6CHR_03962	COG2948	multi-organism process
H6CHR_03965	COG3846	protein secretion by the type IV secretion system
H6CHR_03968	COG3451	type IV secretory pathway VirB4
H6CHR_03971	COG4962	Type ii secretion system protein e
H6CHR_03974	COG0583	DNA-binding transcription factor activity
H6CHR_03977	COG0066	3-isopropylmalate dehydratase activity
H6CHR_03978	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H6CHR_03985	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_03994	COG1454	alcohol dehydrogenase
H6CHR_03999	COG1414	Transcriptional regulator
H6CHR_04006	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H6CHR_04007	COG2855	membrane
H6CHR_04011	COG2188	Transcriptional regulator
H6CHR_04015	COG3328	transposase activity
H6CHR_04017	COG1024	Enoyl-CoA hydratase
H6CHR_04021	COG0183	Belongs to the thiolase family
H6CHR_04023	COG2828	Protein conserved in bacteria
H6CHR_04024	COG1024	Enoyl-CoA hydratase
H6CHR_04034	COG4959	Type IV secretory pathway protease TraF
H6CHR_04037	COG1192	Involved in chromosome partitioning
H6CHR_04045	COG5489	Protein of unknown function (DUF736)
H6CHR_04047	COG1475	DNA binding
H6CHR_04050	COG2003	Belongs to the UPF0758 family
H6CHR_04055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H6CHR_04056	COG0582	viral genome integration into host DNA
H6CHR_04059	COG0776	regulation of translation
H6CHR_04060	COG0072	phenylalanine-tRNA ligase activity
H6CHR_04060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6CHR_04061	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H6CHR_04062	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H6CHR_04063	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H6CHR_04064	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H6CHR_04065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H6CHR_04066	COG2224	Isocitrate lyase
H6CHR_04072	COG1309	transcriptional regulator
H6CHR_04074	COG0673	inositol 2-dehydrogenase activity
H6CHR_04079	COG1082	Xylose isomerase domain protein TIM barrel
H6CHR_04082	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H6CHR_04087	COG0659	secondary active sulfate transmembrane transporter activity
H6CHR_04091	COG0542	response to heat
H6CHR_04095	COG0583	DNA-binding transcription factor activity
H6CHR_04096	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_04097	COG0314	molybdopterin synthase activity
H6CHR_04098	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H6CHR_04099	COG0303	'Molybdopterin
H6CHR_04100	COG1763	Mo-molybdopterin cofactor biosynthetic process
H6CHR_04101	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H6CHR_04103	COG0436	Aminotransferase
H6CHR_04105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H6CHR_04106	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H6CHR_04109	COG0305	Participates in initiation and elongation during chromosome replication
H6CHR_04110	COG0359	binds to the 23S rRNA
H6CHR_04111	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H6CHR_04112	COG2965	DNA replication, synthesis of RNA primer
H6CHR_04113	COG0360	Binds together with S18 to 16S ribosomal RNA
H6CHR_04116	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H6CHR_04117	COG3634	alkyl hydroperoxide reductase activity
H6CHR_04124	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H6CHR_04125	COG0670	Belongs to the BI1 family
H6CHR_04126	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H6CHR_04129	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H6CHR_04130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H6CHR_04134	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6CHR_04137	COG0473	3-isopropylmalate dehydrogenase activity
H6CHR_04138	COG0596	Alpha beta hydrolase
H6CHR_04139	COG0583	DNA-binding transcription factor activity
H6CHR_04143	COG0322	excinuclease ABC activity
H6CHR_04145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H6CHR_04146	COG1611	Belongs to the LOG family
H6CHR_04149	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H6CHR_04151	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H6CHR_04152	COG3237	CsbD-like
H6CHR_04154	COG0824	Thioesterase
H6CHR_04155	COG0123	including yeast histone deacetylase and acetoin utilization protein
H6CHR_04158	COG1959	2 iron, 2 sulfur cluster binding
H6CHR_04158	COG1295	ribonuclease BN
H6CHR_04161	COG2814	Major facilitator Superfamily
H6CHR_04164	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_04165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6CHR_04175	COG1802	Transcriptional regulator
H6CHR_04177	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H6CHR_04179	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_04183	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_04184	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6CHR_04185	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_04186	COG2186	Transcriptional regulator
H6CHR_04187	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6CHR_04188	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_04191	COG2721	sulfolactate sulfo-lyase activity
H6CHR_04192	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04193	COG2706	6-phosphogluconolactonase activity
H6CHR_04194	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_04195	COG0688	phosphatidylethanolamine metabolic process
H6CHR_04198	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H6CHR_04199	COG0443	Heat shock 70 kDa protein
H6CHR_04200	COG0484	heat shock protein binding
H6CHR_04201	COG0179	Fumarylacetoacetate (FAA) hydrolase
H6CHR_04203	COG2766	serine protein kinase
H6CHR_04204	COG2718	Belongs to the UPF0229 family
H6CHR_04205	COG2719	SpoVR family
H6CHR_04206	COG2818	Glycosylase
H6CHR_04207	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H6CHR_04209	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H6CHR_04210	COG3265	gluconokinase activity
H6CHR_04213	COG1538	Outer membrane efflux protein
H6CHR_04215	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H6CHR_04217	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_04220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H6CHR_04221	COG0717	Belongs to the dCTP deaminase family
H6CHR_04222	COG0717	Belongs to the dCTP deaminase family
H6CHR_04223	COG0574	Belongs to the PEP-utilizing enzyme family
H6CHR_04223	COG3848	Pyruvate phosphate dikinase
H6CHR_04229	COG0647	UMP catabolic process
H6CHR_04230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H6CHR_04235	COG2267	carboxylic ester hydrolase activity
H6CHR_04237	COG1295	ribonuclease BN
H6CHR_04239	COG0277	FAD linked oxidase domain protein
H6CHR_04240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H6CHR_04241	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H6CHR_04250	COG3852	Histidine kinase
H6CHR_04252	COG0174	glutamine synthetase
H6CHR_04253	COG1058	Belongs to the CinA family
H6CHR_04253	COG1546	Belongs to the CinA family
H6CHR_04258	COG1187	pseudouridine synthase activity
H6CHR_04260	COG4797	methyltransferase
H6CHR_04260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H6CHR_04264	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H6CHR_04268	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H6CHR_04270	COG0287	Prephenate dehydrogenase
H6CHR_04271	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H6CHR_04275	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H6CHR_04280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H6CHR_04281	COG2111	Na H antiporter
H6CHR_04281	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H6CHR_04282	COG1006	Multisubunit Na H antiporter MnhC subunit
H6CHR_04283	COG0651	ATP synthesis coupled electron transport
H6CHR_04285	COG2212	antiporter activity
H6CHR_04286	COG1320	monovalent cation:proton antiporter activity
H6CHR_04301	COG2353	YceI-like domain
H6CHR_04305	COG3608	succinylglutamate desuccinylase aspartoacylase
H6CHR_04305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H6CHR_04308	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H6CHR_04314	COG1027	Aspartate ammonia-lyase
H6CHR_04315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H6CHR_04319	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H6CHR_04322	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H6CHR_04323	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H6CHR_04324	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6CHR_04325	COG1522	sequence-specific DNA binding
H6CHR_04328	COG1122	ATPase activity
H6CHR_04339	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H6CHR_04340	COG2151	metal-sulfur cluster biosynthetic enzyme
H6CHR_04341	COG3396	Phenylacetate-CoA oxygenase
H6CHR_04342	COG3460	Phenylacetate-CoA oxygenase
H6CHR_04343	COG3396	Phenylacetate-CoA oxygenase
H6CHR_04345	COG2050	protein possibly involved in aromatic compounds catabolism
H6CHR_04346	COG1024	Enoyl-CoA hydratase
H6CHR_04348	COG1309	transcriptional regulator
H6CHR_04349	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H6CHR_04358	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H6CHR_04359	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H6CHR_04361	COG1722	exodeoxyribonuclease VII activity
H6CHR_04366	COG1136	(ABC) transporter
H6CHR_04366	COG0577	efflux transmembrane transporter activity
H6CHR_04369	COG3360	Dodecin
H6CHR_04373	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6CHR_04379	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H6CHR_04381	COG0210	DNA helicase
H6CHR_04382	COG0515	serine threonine protein kinase
H6CHR_04383	COG0516	GMP reductase activity
H6CHR_04386	COG0183	Belongs to the thiolase family
H6CHR_04389	COG0513	Belongs to the DEAD box helicase family
H6CHR_04390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H6CHR_04391	COG0501	Belongs to the peptidase M48B family
H6CHR_04392	COG2154	pterin-4-alpha-carbinolamine dehydratase
H6CHR_04393	COG1162	GTPase activity
H6CHR_04394	COG0438	transferase activity, transferring glycosyl groups
H6CHR_04395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H6CHR_04396	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H6CHR_04397	COG0494	nUDIX hydrolase
H6CHR_04398	COG0335	large ribosomal subunit rRNA binding
H6CHR_04399	COG0336	Belongs to the RNA methyltransferase TrmD family
H6CHR_04400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H6CHR_04401	COG0228	four-way junction DNA binding
H6CHR_04404	COG0306	phosphate transporter
H6CHR_04405	COG1392	Phosphate transport regulator
H6CHR_04406	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H6CHR_04407	COG0617	tRNA 3'-terminal CCA addition
H6CHR_04408	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H6CHR_04409	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H6CHR_04410	COG0628	permease
H6CHR_04412	COG0438	transferase activity, transferring glycosyl groups
H6CHR_04416	COG0728	peptidoglycan biosynthetic process
H6CHR_04417	COG0268	Binds directly to 16S ribosomal RNA
H6CHR_04419	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H6CHR_04420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H6CHR_04421	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H6CHR_04423	COG3483	tryptophan 2,3-dioxygenase activity
H6CHR_04425	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_04432	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_04435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H6CHR_04440	COG2301	Belongs to the HpcH HpaI aldolase family
H6CHR_04441	COG4106	trans-aconitate 2-methyltransferase activity
H6CHR_04442	COG0039	L-malate dehydrogenase activity
H6CHR_04443	COG2188	Transcriptional regulator
H6CHR_04446	COG1053	succinate dehydrogenase
H6CHR_04447	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H6CHR_04448	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H6CHR_04449	COG0372	Belongs to the citrate synthase family
H6CHR_04452	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H6CHR_04453	COG0066	3-isopropylmalate dehydratase activity
H6CHR_04454	COG0473	3-isopropylmalate dehydrogenase activity
H6CHR_04455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H6CHR_04457	COG0101	tRNA pseudouridine synthase activity
H6CHR_04458	COG0135	phosphoribosylanthranilate isomerase activity
H6CHR_04459	COG0133	tryptophan synthase activity
H6CHR_04460	COG0159	tryptophan synthase activity
H6CHR_04461	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H6CHR_04462	COG0762	integral membrane protein
H6CHR_04464	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H6CHR_04465	COG0443	Heat shock 70 kDa protein
H6CHR_04466	COG1451	nucleotide metabolic process
H6CHR_04468	COG0736	holo-[acyl-carrier-protein] synthase activity
H6CHR_04469	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H6CHR_04470	COG1381	Involved in DNA repair and RecF pathway recombination
H6CHR_04471	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H6CHR_04472	COG0571	ribonuclease III activity
H6CHR_04474	COG0681	Belongs to the peptidase S26 family
H6CHR_04475	COG0481	GTPase activity
H6CHR_04476	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_04480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H6CHR_04481	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6CHR_04482	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04483	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H6CHR_04484	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H6CHR_04485	COG0416	fatty acid biosynthetic process
H6CHR_04486	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H6CHR_04487	COG1399	metal-binding, possibly nucleic acid-binding protein
H6CHR_04488	COG0424	maF-like protein
H6CHR_04489	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H6CHR_04490	COG2223	nitrite transmembrane transporter activity
H6CHR_04491	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H6CHR_04491	COG0616	signal peptide processing
H6CHR_04495	COG1530	ribonuclease E activity
H6CHR_04498	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6CHR_04502	COG0297	glycogen (starch) synthase activity
H6CHR_04503	COG3206	protein involved in exopolysaccharide biosynthesis
H6CHR_04503	COG0489	protein tyrosine kinase activity
H6CHR_04504	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H6CHR_04509	COG0181	hydroxymethylbilane synthase activity
H6CHR_04510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H6CHR_04511	COG0583	DNA-binding transcription factor activity
H6CHR_04512	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H6CHR_04522	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H6CHR_04522	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H6CHR_04525	COG3022	response to hydroperoxide
H6CHR_04526	COG0525	valine-tRNA ligase activity
H6CHR_04529	COG0425	Belongs to the sulfur carrier protein TusA family
H6CHR_04530	COG2816	NAD+ diphosphatase activity
H6CHR_04533	COG0724	RNA recognition motif
H6CHR_04537	COG2197	response regulator
H6CHR_04538	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_04547	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_04548	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H6CHR_04549	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H6CHR_04550	COG1674	ftsk spoiiie
H6CHR_04552	COG0492	ferredoxin-NADP+ reductase activity
H6CHR_04553	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H6CHR_04554	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H6CHR_04556	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6CHR_04556	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6CHR_04557	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H6CHR_04558	COG1960	acyl-CoA dehydrogenase activity
H6CHR_04559	COG1960	acyl-CoA dehydrogenase activity
H6CHR_04561	COG1024	Enoyl-CoA hydratase
H6CHR_04563	COG0196	riboflavin kinase activity
H6CHR_04565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H6CHR_04566	COG1283	sodium-dependent phosphate transmembrane transporter activity
H6CHR_04568	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04570	COG0405	Gamma-glutamyltransferase
H6CHR_04571	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_04574	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6CHR_04575	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H6CHR_04578	COG0084	hydrolase, TatD family'
H6CHR_04579	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_04580	COG0714	Associated with various cellular activities
H6CHR_04582	COG2304	oxidoreductase activity
H6CHR_04583	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04584	COG0583	DNA-binding transcription factor activity
H6CHR_04585	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_04586	COG0445	tRNA wobble uridine modification
H6CHR_04591	COG3550	peptidyl-serine autophosphorylation
H6CHR_04593	COG1136	(ABC) transporter
H6CHR_04596	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H6CHR_04602	COG0831	urea catabolic process
H6CHR_04604	COG0832	Belongs to the urease beta subunit family
H6CHR_04605	COG0804	urea catabolic process
H6CHR_04606	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H6CHR_04607	COG0830	nickel cation binding
H6CHR_04608	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H6CHR_04610	COG0028	Belongs to the TPP enzyme family
H6CHR_04616	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H6CHR_04617	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H6CHR_04618	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H6CHR_04620	COG0515	serine threonine protein kinase
H6CHR_04620	COG2815	serine threonine protein kinase
H6CHR_04621	COG1561	YicC-like family, N-terminal region
H6CHR_04622	COG0194	GDP metabolic process
H6CHR_04623	COG1758	RNA polymerase activity
H6CHR_04624	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H6CHR_04628	COG1420	regulation of RNA biosynthetic process
H6CHR_04629	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H6CHR_04630	COG0497	DNA recombination
H6CHR_04631	COG1660	Displays ATPase and GTPase activities
H6CHR_04633	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H6CHR_04634	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H6CHR_04637	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H6CHR_04639	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H6CHR_04640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H6CHR_04641	COG0193	aminoacyl-tRNA hydrolase activity
H6CHR_04643	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H6CHR_04645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6CHR_04647	COG4608	Belongs to the ABC transporter superfamily
H6CHR_04648	COG0747	negative chemotaxis
H6CHR_04649	COG0154	amidase activity
H6CHR_04650	COG0583	DNA-binding transcription factor activity
H6CHR_04656	COG0406	alpha-ribazole phosphatase activity
H6CHR_04657	COG2267	carboxylic ester hydrolase activity
H6CHR_04659	COG0508	dehydrogenase complex catalyzes the overall conversion of
H6CHR_04660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6CHR_04661	COG0596	Alpha beta hydrolase
H6CHR_04662	COG0280	phosphate acetyltransferase
H6CHR_04662	COG0281	malic enzyme
H6CHR_04663	COG1301	dicarboxylic acid transport
H6CHR_04664	COG1252	NADH dehydrogenase
H6CHR_04665	COG3243	poly(R)-hydroxyalkanoic acid synthase
H6CHR_04666	COG0183	Belongs to the thiolase family
H6CHR_04667	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04669	COG1271	oxidase subunit
H6CHR_04670	COG1294	oxidase, subunit
H6CHR_04673	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H6CHR_04674	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H6CHR_04675	COG1984	allophanate hydrolase subunit 2
H6CHR_04676	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H6CHR_04677	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H6CHR_04678	COG0742	ribosomal rna small subunit methyltransferase
H6CHR_04679	COG0612	Peptidase, M16
H6CHR_04680	COG0612	Peptidase, M16
H6CHR_04683	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H6CHR_04684	COG1999	signal sequence binding
H6CHR_04685	COG0109	protoheme IX farnesyltransferase activity
H6CHR_04692	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H6CHR_04694	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H6CHR_04695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H6CHR_04697	COG2226	methyltransferase
H6CHR_04699	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H6CHR_04705	COG1024	Enoyl-CoA hydratase
H6CHR_04709	COG1960	acyl-CoA dehydrogenase activity
H6CHR_04714	COG2423	ornithine cyclodeaminase activity
H6CHR_04715	COG0183	Belongs to the thiolase family
H6CHR_04716	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H6CHR_04718	COG1414	Transcriptional regulator
H6CHR_04721	COG0776	regulation of translation
H6CHR_04722	COG4948	Mandelate Racemase Muconate Lactonizing
H6CHR_04724	COG0366	Alpha amylase catalytic
H6CHR_04725	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04726	COG0583	DNA-binding transcription factor activity
H6CHR_04727	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04728	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_04730	COG3959	Transketolase, thiamine diphosphate binding domain
H6CHR_04731	COG3958	Transketolase
H6CHR_04732	COG2084	Dehydrogenase
H6CHR_04739	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H6CHR_04741	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H6CHR_04742	COG0583	DNA-binding transcription factor activity
H6CHR_04745	COG1196	nuclear chromosome segregation
H6CHR_04748	COG1446	asparaginase
H6CHR_04749	COG4172	Belongs to the ABC transporter superfamily
H6CHR_04750	COG0747	negative chemotaxis
H6CHR_04761	COG1450	Type ii and iii secretion system protein
H6CHR_04766	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6CHR_04767	COG1459	type II secretion system
H6CHR_04777	COG1137	ATPase activity
H6CHR_04780	COG1012	belongs to the aldehyde dehydrogenase family
H6CHR_04791	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04792	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_04793	COG1902	pentaerythritol trinitrate reductase activity
H6CHR_04794	COG0583	DNA-binding transcription factor activity
H6CHR_04796	COG0583	DNA-binding transcription factor activity
H6CHR_04797	COG3485	protocatechuate 3,4-dioxygenase
H6CHR_04798	COG3485	protocatechuate 3,4-dioxygenase
H6CHR_04800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6CHR_04807	COG0582	viral genome integration into host DNA
H6CHR_04816	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H6CHR_04821	COG0540	Belongs to the ATCase OTCase family
H6CHR_04822	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H6CHR_04823	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H6CHR_04824	COG1678	Uncharacterized ACR, COG1678
H6CHR_04825	COG0415	Belongs to the DNA photolyase family
H6CHR_04826	COG2198	Histidine kinase
H6CHR_04826	COG0784	Response regulator, receiver
H6CHR_04826	COG0643	Histidine kinase
H6CHR_04831	COG1773	rubredoxin
H6CHR_04833	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H6CHR_04834	COG0138	bifunctional purine biosynthesis protein purh
H6CHR_04837	COG1238	metal cluster binding
H6CHR_04838	COG0012	GTP binding
H6CHR_04839	COG0633	Ferredoxin
H6CHR_04839	COG3217	Mosc domain protein beta barrel domain protein
H6CHR_04840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_04843	COG1024	Enoyl-CoA hydratase
H6CHR_04852	COG2255	four-way junction helicase activity
H6CHR_04853	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H6CHR_04854	COG2267	carboxylic ester hydrolase activity
H6CHR_04855	COG2453	phosphatase
H6CHR_04855	COG0671	phosphoesterase, PA-phosphatase related
H6CHR_04858	COG4589	Belongs to the CDS family
H6CHR_04859	COG0632	four-way junction helicase activity
H6CHR_04860	COG1702	phosphate starvation-inducible protein PhoH
H6CHR_04861	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H6CHR_04862	COG1490	D-aminoacyl-tRNA deacylase activity
H6CHR_04863	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H6CHR_04866	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H6CHR_04867	COG0739	heme binding
H6CHR_04868	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H6CHR_04869	COG2814	Major facilitator Superfamily
H6CHR_04870	COG0316	Belongs to the HesB IscA family
H6CHR_04871	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H6CHR_04872	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H6CHR_04873	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H6CHR_04874	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H6CHR_04877	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H6CHR_04879	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H6CHR_04883	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H6CHR_04885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_04891	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H6CHR_04894	COG0477	Major facilitator Superfamily
H6CHR_04899	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6CHR_04901	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H6CHR_04902	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H6CHR_04904	COG0156	8-amino-7-oxononanoate synthase activity
H6CHR_04907	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H6CHR_04909	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H6CHR_04910	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_04911	COG1960	acyl-CoA dehydrogenase activity
H6CHR_04914	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H6CHR_04915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H6CHR_04919	COG3012	SEC-C Motif Domain Protein
H6CHR_04922	COG1960	acyl-CoA dehydrogenase activity
H6CHR_04925	COG0183	Belongs to the thiolase family
H6CHR_04926	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H6CHR_04927	COG0288	reversible hydration of carbon dioxide
H6CHR_04928	COG0789	Transcriptional regulator
H6CHR_04931	COG0564	pseudouridine synthase activity
H6CHR_04932	COG2197	response regulator
H6CHR_04933	COG5002	protein histidine kinase activity
H6CHR_04937	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H6CHR_04938	COG0751	glycine-tRNA ligase activity
H6CHR_04939	COG0752	glycyl-tRNA synthetase alpha subunit
H6CHR_04940	COG0252	asparaginase activity
H6CHR_04942	COG0366	Alpha amylase catalytic
H6CHR_04943	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H6CHR_04944	COG4535	Mg2 and Co2 transporter CorC
H6CHR_04950	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_04957	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_04958	COG0436	Aminotransferase
H6CHR_04960	COG0697	spore germination
H6CHR_04961	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6CHR_04963	COG1280	lysine exporter protein (LysE YggA)
H6CHR_04964	COG0625	glutathione transferase activity
H6CHR_04965	COG0384	phenazine biosynthesis protein PhzF
H6CHR_04970	COG3468	outer membrane autotransporter barrel domain protein
H6CHR_04972	COG1324	tolerance protein
H6CHR_04978	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H6CHR_04980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6CHR_04981	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H6CHR_04982	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H6CHR_04985	COG0679	Auxin Efflux Carrier
H6CHR_04986	COG0210	DNA helicase
H6CHR_04990	COG1960	acyl-CoA dehydrogenase activity
H6CHR_04991	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_04992	COG0583	DNA-binding transcription factor activity
H6CHR_04994	COG1053	succinate dehydrogenase
H6CHR_05007	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_05012	COG3210	domain, Protein
H6CHR_05016	COG0596	Alpha beta hydrolase
H6CHR_05017	COG1802	Transcriptional regulator
H6CHR_05018	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H6CHR_05019	COG1116	anion transmembrane transporter activity
H6CHR_05020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6CHR_05024	COG2204	response regulator
H6CHR_05025	COG5000	phosphorelay sensor kinase activity
H6CHR_05027	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6CHR_05027	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6CHR_05029	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H6CHR_05030	COG0085	RNA polymerase activity
H6CHR_05031	COG0222	ribosome binding
H6CHR_05032	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H6CHR_05033	COG0081	regulation of translation
H6CHR_05034	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H6CHR_05036	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H6CHR_05038	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H6CHR_05042	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H6CHR_05043	COG0134	indole-3-glycerol-phosphate synthase activity
H6CHR_05044	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H6CHR_05045	COG1280	lysine exporter protein (LysE YggA)
H6CHR_05053	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_05057	COG0559	Belongs to the binding-protein-dependent transport system permease family
H6CHR_05058	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H6CHR_05063	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_05064	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H6CHR_05069	COG4638	Rieske (2fe-2S)
H6CHR_05074	COG2313	pseudouridylate synthase activity
H6CHR_05075	COG0604	alcohol dehydrogenase
H6CHR_05077	COG1250	3-hydroxyacyl-CoA dehydrogenase
H6CHR_05079	COG0546	phosphoglycolate phosphatase activity
H6CHR_05080	COG2197	response regulator
H6CHR_05082	COG3916	Acyl-homoserine-lactone synthase
H6CHR_05084	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H6CHR_05084	COG2885	chlorophyll binding
H6CHR_05086	COG0745	RESPONSE REGULATOR receiver
H6CHR_05094	COG0631	protein serine/threonine phosphatase activity
H6CHR_05095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H6CHR_05103	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H6CHR_05104	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H6CHR_05105	COG0784	Response regulator, receiver
H6CHR_05105	COG2205	protein histidine kinase activity
H6CHR_05107	COG4251	negative regulation of phosphorylation
H6CHR_05108	COG1309	transcriptional regulator
H6CHR_05119	COG2030	dehydratase
H6CHR_05120	COG1024	Enoyl-CoA hydratase
H6CHR_05125	COG0018	arginyl-trna synthetase
H6CHR_05127	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H6CHR_05128	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H6CHR_05129	COG1137	ATPase activity
H6CHR_05130	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H6CHR_05131	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6CHR_05132	COG1609	Transcriptional regulator
H6CHR_05133	COG4948	Mandelate Racemase Muconate Lactonizing
H6CHR_05136	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_05137	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H6CHR_05139	COG1175	transmembrane transport
H6CHR_05141	COG2186	Transcriptional regulator
H6CHR_05148	COG4585	Histidine kinase
H6CHR_05149	COG2197	response regulator
H6CHR_05152	COG3179	chitinase
H6CHR_05155	COG0653	protein targeting
H6CHR_05163	COG2197	response regulator
H6CHR_05164	COG2198	Histidine kinase
H6CHR_05164	COG2205	protein histidine kinase activity
H6CHR_05164	COG0784	Response regulator, receiver
H6CHR_05167	COG1396	sequence-specific DNA binding
H6CHR_05168	COG0235	Class ii aldolase
H6CHR_05169	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H6CHR_05172	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H6CHR_05174	COG2967	ApaG domain
H6CHR_05175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H6CHR_05182	COG0673	inositol 2-dehydrogenase activity
H6CHR_05183	COG0277	FAD linked oxidase domain protein
H6CHR_05188	COG0445	tRNA wobble uridine modification
H6CHR_05189	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_05190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6CHR_05191	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H6CHR_05192	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6CHR_05194	COG2376	Dihydroxyacetone kinase
H6CHR_05195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6CHR_05198	COG2084	Dehydrogenase
H6CHR_05202	COG1609	Transcriptional regulator
H6CHR_05212	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_05213	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6CHR_05217	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H6CHR_05218	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H6CHR_05223	COG0583	DNA-binding transcription factor activity
H6CHR_05225	COG0583	DNA-binding transcription factor activity
H6CHR_05228	COG0205	6-phosphofructokinase activity
H6CHR_05231	COG2814	Major facilitator Superfamily
H6CHR_05232	COG0121	glutamine amidotransferase
H6CHR_05236	COG0189	ligase activity
H6CHR_05237	COG3135	benzoate transporter
H6CHR_05238	COG3158	transport of potassium into the cell
H6CHR_05240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H6CHR_05243	COG0495	leucyl-tRNA aminoacylation
H6CHR_05246	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H6CHR_05247	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6CHR_05248	COG0735	belongs to the Fur family
H6CHR_05249	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H6CHR_05251	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H6CHR_05252	COG0210	DNA helicase
H6CHR_05253	COG0598	Magnesium transport protein CorA
H6CHR_05255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H6CHR_05256	COG0318	PFAM AMP-dependent synthetase and ligase
H6CHR_05261	COG0745	RESPONSE REGULATOR receiver
H6CHR_05264	COG0482	sulfurtransferase activity
H6CHR_05266	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H6CHR_05270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H6CHR_05277	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6CHR_05278	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H6CHR_05279	COG0489	protein tyrosine kinase activity
H6CHR_05279	COG3206	protein involved in exopolysaccharide biosynthesis
H6CHR_05280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H6CHR_05281	COG1596	polysaccharide export
H6CHR_05282	COG0629	single-stranded DNA binding
H6CHR_05288	COG0446	pyridine nucleotide-disulphide oxidoreductase
H6CHR_05289	COG3181	Tripartite tricarboxylate transporter family receptor
H6CHR_05291	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_05294	COG0583	DNA-binding transcription factor activity
H6CHR_05296	COG2205	protein histidine kinase activity
H6CHR_05296	COG3437	response regulator, receiver
H6CHR_05296	COG3850	Histidine kinase
H6CHR_05296	COG4999	Histidine kinase
H6CHR_05298	COG0745	RESPONSE REGULATOR receiver
H6CHR_05299	COG0179	Fumarylacetoacetate (FAA) hydrolase
H6CHR_05300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H6CHR_05302	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_05308	COG0284	orotidine-5'-phosphate decarboxylase activity
H6CHR_05310	COG0456	acetyltransferase
H6CHR_05311	COG1214	PFAM Peptidase M22, glycoprotease
H6CHR_05314	COG0009	L-threonylcarbamoyladenylate synthase
H6CHR_05315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H6CHR_05316	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H6CHR_05317	COG3118	belongs to the thioredoxin family
H6CHR_05321	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H6CHR_05323	COG0469	pyruvate kinase activity
H6CHR_05324	COG0126	phosphoglycerate kinase activity
H6CHR_05328	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_05332	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H6CHR_05334	COG0242	peptide deformylase activity
H6CHR_05336	COG0758	DNA mediated transformation
H6CHR_05337	COG2922	Belongs to the Smg family
H6CHR_05341	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6CHR_05342	COG1862	Preprotein translocase
H6CHR_05344	COG1522	sequence-specific DNA binding
H6CHR_05345	COG2814	Major facilitator Superfamily
H6CHR_05346	COG1959	2 iron, 2 sulfur cluster binding
H6CHR_05352	COG0402	S-adenosylhomocysteine deaminase activity
H6CHR_05353	COG3622	Belongs to the hyi family
H6CHR_05354	COG0235	Class ii aldolase
H6CHR_05355	COG3395	kinase activity
H6CHR_05356	COG2084	Dehydrogenase
H6CHR_05359	COG0513	Belongs to the DEAD box helicase family
H6CHR_05360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H6CHR_05361	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6CHR_05363	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H6CHR_05367	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H6CHR_05367	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H6CHR_05376	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H6CHR_05377	COG2137	regulation of response to DNA damage stimulus
H6CHR_05378	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H6CHR_05379	COG0045	succinate-CoA ligase (ADP-forming) activity
H6CHR_05380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H6CHR_05381	COG0861	Integral membrane protein TerC family
H6CHR_05382	COG0631	protein serine/threonine phosphatase activity
H6CHR_05386	COG4969	Belongs to the N-Me-Phe pilin family
H6CHR_05394	COG0315	cyclic pyranopterin monophosphate synthase activity
H6CHR_05396	COG1950	PFAM Membrane protein of
H6CHR_05398	COG0861	Integral membrane protein TerC family
H6CHR_05405	COG4269	membrane
H6CHR_05406	COG0625	glutathione transferase activity
H6CHR_05409	COG1595	DNA-templated transcription, initiation
H6CHR_05411	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H6CHR_05415	COG4566	intracellular signal transduction
H6CHR_05416	COG2885	chlorophyll binding
H6CHR_05418	COG2076	Multidrug Resistance protein
H6CHR_05419	COG0546	phosphoglycolate phosphatase activity
H6CHR_05419	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H6CHR_05422	COG1522	sequence-specific DNA binding
H6CHR_05424	COG1309	transcriptional regulator
H6CHR_05425	COG0346	lactoylglutathione lyase activity
H6CHR_05431	COG1546	Belongs to the CinA family
H6CHR_05431	COG1058	Belongs to the CinA family
H6CHR_05432	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_05434	COG1028	Short-chain dehydrogenase reductase Sdr
H6CHR_05435	COG1047	Peptidyl-prolyl cis-trans
H6CHR_05440	COG0667	Aldo Keto reductase
H6CHR_05444	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H6CHR_05447	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6CHR_05452	COG2205	protein histidine kinase activity
H6CHR_05453	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H6CHR_05457	COG0514	ATP-dependent DNA helicase (RecQ)
H6CHR_05471	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6CHR_05472	COG1063	alcohol dehydrogenase
H6CHR_05473	COG0673	inositol 2-dehydrogenase activity
H6CHR_05482	COG2204	response regulator
H6CHR_05484	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H6CHR_05485	COG3546	catalase activity
H6CHR_05490	COG3239	Fatty acid desaturase
H6CHR_05494	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H6CHR_05496	COG1137	ATPase activity
H6CHR_05500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H6CHR_05502	COG3485	protocatechuate 3,4-dioxygenase
H6CHR_05503	COG0583	DNA-binding transcription factor activity
H6CHR_05506	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H6CHR_05510	COG4977	sequence-specific DNA binding
H6CHR_05516	COG4948	Mandelate Racemase Muconate Lactonizing
H6CHR_05519	COG0179	Fumarylacetoacetate (FAA) hydrolase
H6CHR_05520	COG4221	oxidoreductase activity
H6CHR_05523	COG0587	DNA-directed DNA polymerase activity
H6CHR_05534	COG0445	tRNA wobble uridine modification
H6CHR_05536	COG1295	ribonuclease BN
H6CHR_05551	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6CHR_05557	COG3237	CsbD-like
H6CHR_05563	COG0247	lactate metabolic process
H6CHR_05563	COG0277	FAD linked oxidase domain protein
H6CHR_05565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H6CHR_05568	COG2094	Belongs to the DNA glycosylase MPG family
H6CHR_05576	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H6CHR_05581	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H6CHR_05582	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H6CHR_05583	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H6CHR_05584	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H6CHR_05588	COG0006	proline dipeptidase activity
H6CHR_05592	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H6CHR_05596	COG0281	malic enzyme
H6CHR_05596	COG0280	phosphate acetyltransferase
H6CHR_05600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H6CHR_05601	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6CHR_05602	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H6CHR_05604	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H6CHR_05606	COG3753	Protein conserved in bacteria
H6CHR_05607	COG2814	Major facilitator Superfamily
H6CHR_05611	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6CHR_05612	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H6CHR_05612	COG2813	Specifically methylates the guanine in position
H6CHR_05613	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H6CHR_05614	COG2119	membrane
H6CHR_05615	COG0724	RNA recognition motif
H6CHR_05616	COG0300	oxidoreductase activity
H6CHR_05618	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H6CHR_05623	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H6CHR_05624	COG0706	membrane insertase activity
H6CHR_05625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H6CHR_05626	COG0594	ribonuclease P activity
H6CHR_05627	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H6P1_00005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H6P1_00011	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H6P1_00012	COG1196	nuclear chromosome segregation
H6P1_00012	COG0741	lytic transglycosylase activity
H6P1_00012	COG0739	heme binding
H6P1_00013	COG0187	DNA topoisomerase II activity
H6P1_00015	COG1484	DNA-dependent DNA replication
H6P1_00017	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H6P1_00024	COG0653	protein targeting
H6P1_00031	COG0210	DNA helicase
H6P1_00056	COG0582	viral genome integration into host DNA
H6P1_00071	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H6P1_00072	COG0840	transmembrane signaling receptor activity
H6P1_00080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H6P1_00081	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H6P1_00108	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6P1_00108	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6P1_00115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H6P1_00122	COG0629	single-stranded DNA binding
H6P1_00132	COG0328	RNA-DNA hybrid ribonuclease activity
H6P1_00165	COG4974	Belongs to the 'phage' integrase family
H6P1_00180	COG0494	nUDIX hydrolase
H6P1_00186	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H6P1_00190	COG1484	DNA-dependent DNA replication
H6P1_00191	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6P1_00201	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H6P1_00216	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H6P1_00225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H6P1_00225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H6P1_00229	COG1056	cytidyltransferase-related domain
H6P1_00229	COG1051	belongs to the nudix hydrolase family
H6P1_00232	COG0617	tRNA 3'-terminal CCA addition
H6P1_00251	COG0557	exoribonuclease II activity
H6P1_00262	COG1199	ATP-dependent helicase activity
H6P1_00263	COG1222	aaa ATPase
H6P1_00271	COG0675	Transposase, IS605 OrfB family
H6P1_00284	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H6P1_00291	COG1129	ABC transporter
H6P1_00293	COG0628	permease
H6P1_00295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6P1_00301	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H6P1_00306	COG2268	Band 7 protein
H6P1_00367	COG0084	hydrolase, TatD family'
H6P1_00377	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H6P1_00391	COG0587	DNA-directed DNA polymerase activity
H6P1_00392	COG1203	CRISPR-associated helicase, Cas3
H6P1_00393	COG1518	maintenance of DNA repeat elements
H6P1_00400	COG4637	Psort location Cytoplasmic, score
H6P1_00405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H6P1_00457	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H6P1_00462	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H6P1_00478	COG4650	regulator
H6P1_00517	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H6P1_00522	COG1484	DNA-dependent DNA replication
H6P1_00525	COG0517	IMP dehydrogenase activity
H6P1_00527	COG0517	IMP dehydrogenase activity
H6P1_00537	COG0517	IMP dehydrogenase activity
H6P1_00540	COG0517	IMP dehydrogenase activity
H6P1_00554	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6P1_00555	COG3181	Tripartite tricarboxylate transporter family receptor
H6P1_00558	COG1454	alcohol dehydrogenase
H6P1_00562	COG3181	Tripartite tricarboxylate transporter family receptor
H6P1_00564	COG2801	Transposase and inactivated derivatives
H6P1_00576	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H6P1_00576	COG0519	Catalyzes the synthesis of GMP from XMP
H6P1_00583	COG4286	Uncharacterised protein family (UPF0160)
H6P1_00590	COG1074	ATP-dependent DNA helicase activity
H6P1_00608	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6P1_00628	COG1484	DNA-dependent DNA replication
H6P1_00629	COG4584	PFAM Integrase catalytic
H6P1_00659	COG0215	cysteine-tRNA ligase activity
H6P1_00661	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H6P1_00683	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H6P1_00704	COG3011	Protein conserved in bacteria
H6P1_00708	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H6P1_00720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H6P1_00727	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H6P1_00745	COG2954	triphosphatase activity
H6P1_00747	COG0545	Peptidyl-prolyl cis-trans isomerase
H6P1_00783	COG4974	Belongs to the 'phage' integrase family
H6P1_00788	COG3384	dioxygenase
H6P1_00797	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6P1_00797	COG0551	DNA topoisomerase type I activity
H6P1_00816	COG0433	COG0433 Predicted ATPase
H6P1_00817	COG4682	membrane
H6P1_00871	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H6P1_00872	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H6P1_00880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H6P1_00881	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H6P1_00886	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6P1_00897	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H6P1_00930	COG1199	ATP-dependent helicase activity
H6P1_00933	COG1192	Involved in chromosome partitioning
H6P2_00014	COG2948	multi-organism process
H6P2_00023	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6P2_00040	COG2003	Belongs to the UPF0758 family