locus-tag	class	description
H4CHR_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4CHR_00006	COG1408	metallophosphoesterase
H4CHR_00008	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H4CHR_00010	COG0632	four-way junction helicase activity
H4CHR_00011	COG0392	lysyltransferase activity
H4CHR_00012	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_00013	COG3568	Endonuclease Exonuclease Phosphatase
H4CHR_00019	COG1178	ABC-type Fe3 transport system permease component
H4CHR_00020	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4CHR_00022	COG3842	ATPase activity
H4CHR_00023	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4CHR_00028	COG2205	protein histidine kinase activity
H4CHR_00029	COG0745	RESPONSE REGULATOR receiver
H4CHR_00031	COG2217	Heavy metal translocating P-type atpase
H4CHR_00033	COG0642	Histidine kinase
H4CHR_00034	COG1902	pentaerythritol trinitrate reductase activity
H4CHR_00035	COG0477	Major facilitator Superfamily
H4CHR_00039	COG0445	tRNA wobble uridine modification
H4CHR_00040	COG0357	Ribosomal RNA small subunit methyltransferase G
H4CHR_00042	COG1192	Involved in chromosome partitioning
H4CHR_00044	COG1475	DNA binding
H4CHR_00046	COG0277	FAD linked oxidase domain protein
H4CHR_00047	COG2096	Adenosyltransferase
H4CHR_00055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H4CHR_00057	COG0850	regulation of cytokinetic process
H4CHR_00059	COG2233	PERMEase
H4CHR_00060	COG2050	protein possibly involved in aromatic compounds catabolism
H4CHR_00063	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4CHR_00069	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4CHR_00070	COG3246	L-lysine catabolic process to acetate
H4CHR_00080	COG3550	peptidyl-serine autophosphorylation
H4CHR_00081	COG2233	PERMEase
H4CHR_00082	COG1192	Involved in chromosome partitioning
H4CHR_00092	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4CHR_00096	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4CHR_00101	COG0583	DNA-binding transcription factor activity
H4CHR_00103	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00104	COG0745	RESPONSE REGULATOR receiver
H4CHR_00104	COG3292	Two component regulator propeller
H4CHR_00104	COG2205	protein histidine kinase activity
H4CHR_00105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H4CHR_00109	COG2205	protein histidine kinase activity
H4CHR_00109	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4CHR_00110	COG0484	heat shock protein binding
H4CHR_00112	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00116	COG0745	RESPONSE REGULATOR receiver
H4CHR_00119	COG0740	serine-type endopeptidase activity
H4CHR_00120	COG0596	Alpha beta hydrolase
H4CHR_00121	COG1393	Belongs to the ArsC family
H4CHR_00129	COG3842	ATPase activity
H4CHR_00130	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4CHR_00131	COG1177	transmembrane transport
H4CHR_00134	COG0251	oxidation-reduction process
H4CHR_00136	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4CHR_00137	COG2267	carboxylic ester hydrolase activity
H4CHR_00139	COG1228	amidohydrolase
H4CHR_00142	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00145	COG0181	hydroxymethylbilane synthase activity
H4CHR_00150	COG2226	methyltransferase
H4CHR_00151	COG0791	NLP P60 protein
H4CHR_00156	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4CHR_00158	COG0596	Alpha beta hydrolase
H4CHR_00159	COG2205	protein histidine kinase activity
H4CHR_00164	COG1051	belongs to the nudix hydrolase family
H4CHR_00170	COG0724	RNA recognition motif
H4CHR_00176	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_00178	COG1024	Enoyl-CoA hydratase
H4CHR_00180	COG0604	alcohol dehydrogenase
H4CHR_00181	COG0583	DNA-binding transcription factor activity
H4CHR_00182	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_00184	COG0583	DNA-binding transcription factor activity
H4CHR_00186	COG1024	Enoyl-CoA hydratase
H4CHR_00189	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00193	COG2205	protein histidine kinase activity
H4CHR_00195	COG2172	sigma factor antagonist activity
H4CHR_00196	COG1366	Belongs to the anti-sigma-factor antagonist family
H4CHR_00197	COG1366	Belongs to the anti-sigma-factor antagonist family
H4CHR_00199	COG0739	heme binding
H4CHR_00204	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4CHR_00208	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4CHR_00209	COG1950	PFAM Membrane protein of
H4CHR_00213	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4CHR_00214	COG0450	alkyl hydroperoxide reductase
H4CHR_00215	COG0583	DNA-binding transcription factor activity
H4CHR_00216	COG1960	acyl-CoA dehydrogenase activity
H4CHR_00217	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_00221	COG4221	oxidoreductase activity
H4CHR_00225	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00225	COG0604	alcohol dehydrogenase
H4CHR_00225	COG3321	synthase
H4CHR_00226	COG3246	L-lysine catabolic process to acetate
H4CHR_00228	COG3485	protocatechuate 3,4-dioxygenase
H4CHR_00229	COG1609	Transcriptional regulator
H4CHR_00231	COG0515	serine threonine protein kinase
H4CHR_00234	COG2066	Belongs to the glutaminase family
H4CHR_00235	COG0697	spore germination
H4CHR_00237	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_00240	COG2188	Transcriptional regulator
H4CHR_00241	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4CHR_00242	COG0700	Nucleoside recognition
H4CHR_00243	COG3540	Alkaline phosphatase
H4CHR_00248	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H4CHR_00250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4CHR_00251	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4CHR_00258	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_00261	COG2986	histidine ammonia-lyase
H4CHR_00262	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H4CHR_00265	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00267	COG1228	amidohydrolase
H4CHR_00274	COG0583	DNA-binding transcription factor activity
H4CHR_00277	COG0646	methionine synthase
H4CHR_00277	COG1410	methionine synthase
H4CHR_00284	COG3210	domain, Protein
H4CHR_00286	COG1309	transcriptional regulator
H4CHR_00297	COG1335	isochorismatase
H4CHR_00298	COG2080	2 iron, 2 sulfur cluster binding
H4CHR_00299	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4CHR_00299	COG2010	Cytochrome c
H4CHR_00303	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00305	COG0606	chelatase, subunit chli
H4CHR_00307	COG0347	Belongs to the P(II) protein family
H4CHR_00308	COG0004	ammonium transporteR
H4CHR_00310	COG0277	FAD linked oxidase domain protein
H4CHR_00311	COG0247	lactate metabolic process
H4CHR_00313	COG0386	Belongs to the glutathione peroxidase family
H4CHR_00315	COG0477	Major facilitator Superfamily
H4CHR_00316	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4CHR_00317	COG3493	citrate carrier protein
H4CHR_00318	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4CHR_00320	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00321	COG0129	dihydroxy-acid dehydratase activity
H4CHR_00323	COG3971	2-oxopent-4-enoate hydratase activity
H4CHR_00325	COG3384	dioxygenase
H4CHR_00326	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_00330	COG1846	Transcriptional regulator
H4CHR_00332	COG1053	succinate dehydrogenase
H4CHR_00334	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00338	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_00340	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00343	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4CHR_00345	COG2974	May be involved in recombination
H4CHR_00351	COG0745	RESPONSE REGULATOR receiver
H4CHR_00359	COG4221	oxidoreductase activity
H4CHR_00362	COG0583	DNA-binding transcription factor activity
H4CHR_00363	COG0708	Exodeoxyribonuclease III
H4CHR_00364	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H4CHR_00366	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4CHR_00367	COG0154	amidase activity
H4CHR_00368	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4CHR_00369	COG1077	Cell shape determining protein MreB Mrl
H4CHR_00372	COG0768	penicillin binding
H4CHR_00374	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4CHR_00375	COG1127	ABC transporter
H4CHR_00379	COG2095	MarC family integral membrane protein
H4CHR_00380	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00382	COG0412	Dienelactone hydrolase
H4CHR_00384	COG0598	Magnesium transport protein CorA
H4CHR_00388	COG3411	Ferredoxin
H4CHR_00389	COG2945	thiolester hydrolase activity
H4CHR_00390	COG1686	Belongs to the peptidase S11 family
H4CHR_00391	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4CHR_00392	COG0049	tRNA binding
H4CHR_00393	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4CHR_00394	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4CHR_00395	COG0051	transcription antitermination factor activity, RNA binding
H4CHR_00398	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H4CHR_00399	COG0088	Forms part of the polypeptide exit tunnel
H4CHR_00400	COG0089	rRNA binding
H4CHR_00401	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4CHR_00402	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4CHR_00403	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4CHR_00404	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H4CHR_00405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4CHR_00406	COG0255	Belongs to the universal ribosomal protein uL29 family
H4CHR_00407	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4CHR_00408	COG0678	peroxiredoxin activity
H4CHR_00409	COG0456	acetyltransferase
H4CHR_00411	COG3909	cytochrome
H4CHR_00412	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4CHR_00415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4CHR_00416	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4CHR_00420	COG3850	Histidine kinase
H4CHR_00420	COG5002	protein histidine kinase activity
H4CHR_00421	COG2130	NADP-dependent
H4CHR_00423	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H4CHR_00424	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_00425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4CHR_00426	COG0321	lipoyl(octanoyl) transferase activity
H4CHR_00427	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4CHR_00429	COG0356	it plays a direct role in the translocation of protons across the membrane
H4CHR_00431	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4CHR_00432	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4CHR_00433	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4CHR_00434	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4CHR_00435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4CHR_00436	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4CHR_00439	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4CHR_00440	COG1879	ABC-type sugar transport system periplasmic component
H4CHR_00441	COG0673	inositol 2-dehydrogenase activity
H4CHR_00449	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4CHR_00449	COG1793	dna ligase
H4CHR_00450	COG1793	dna ligase
H4CHR_00451	COG1201	RNA secondary structure unwinding
H4CHR_00463	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4CHR_00464	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4CHR_00465	COG1309	transcriptional regulator
H4CHR_00469	COG0596	Alpha beta hydrolase
H4CHR_00470	COG0583	DNA-binding transcription factor activity
H4CHR_00472	COG0477	Major facilitator Superfamily
H4CHR_00479	COG0028	Belongs to the TPP enzyme family
H4CHR_00481	COG3386	PFAM SMP-30 Gluconolaconase
H4CHR_00484	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_00485	COG1879	ABC-type sugar transport system periplasmic component
H4CHR_00486	COG4213	ABC transporter substrate-binding protein
H4CHR_00488	COG4214	carbohydrate transport
H4CHR_00489	COG1129	ABC transporter
H4CHR_00490	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4CHR_00491	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4CHR_00498	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4CHR_00519	COG2204	response regulator
H4CHR_00521	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H4CHR_00522	COG0792	nuclease activity
H4CHR_00523	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H4CHR_00525	COG2084	Dehydrogenase
H4CHR_00530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4CHR_00535	COG0010	Belongs to the arginase family
H4CHR_00536	COG3639	organic phosphonate transmembrane transporter activity
H4CHR_00537	COG3639	organic phosphonate transmembrane transporter activity
H4CHR_00538	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H4CHR_00539	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H4CHR_00540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4CHR_00542	COG0709	Synthesizes selenophosphate from selenide and ATP
H4CHR_00545	COG1309	transcriptional regulator
H4CHR_00549	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4CHR_00549	COG2124	cytochrome p450
H4CHR_00553	COG0439	Biotin carboxylase
H4CHR_00556	COG1346	cytolysis
H4CHR_00557	COG1380	Effector of murein hydrolase LrgA
H4CHR_00558	COG0277	FAD linked oxidase domain protein
H4CHR_00571	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_00581	COG1473	amidohydrolase
H4CHR_00594	COG0343	queuine tRNA-ribosyltransferase activity
H4CHR_00595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H4CHR_00596	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4CHR_00598	COG0783	Belongs to the Dps family
H4CHR_00599	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4CHR_00601	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H4CHR_00602	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4CHR_00603	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4CHR_00604	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4CHR_00605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H4CHR_00606	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H4CHR_00607	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H4CHR_00608	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H4CHR_00609	COG1841	ribosomal large subunit assembly
H4CHR_00610	COG0200	Binds to the 23S rRNA
H4CHR_00611	COG0201	protein transport
H4CHR_00613	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4CHR_00614	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H4CHR_00615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4CHR_00616	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4CHR_00617	COG0202	RNA polymerase activity
H4CHR_00618	COG0203	ribosomal protein L17
H4CHR_00622	COG1960	acyl-CoA dehydrogenase activity
H4CHR_00623	COG1024	Enoyl-CoA hydratase
H4CHR_00626	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4CHR_00629	COG0583	DNA-binding transcription factor activity
H4CHR_00630	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00631	COG0022	dehydrogenase e1 component
H4CHR_00632	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4CHR_00642	COG0693	protein deglycase activity
H4CHR_00649	COG1022	Amp-dependent synthetase and ligase
H4CHR_00650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4CHR_00652	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00657	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4CHR_00658	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4CHR_00659	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H4CHR_00660	COG2205	protein histidine kinase activity
H4CHR_00661	COG0745	RESPONSE REGULATOR receiver
H4CHR_00662	COG1187	pseudouridine synthase activity
H4CHR_00663	COG0745	RESPONSE REGULATOR receiver
H4CHR_00674	COG0326	Molecular chaperone. Has ATPase activity
H4CHR_00675	COG2124	cytochrome p450
H4CHR_00676	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4CHR_00678	COG1764	response to oxidative stress
H4CHR_00679	COG1846	Transcriptional regulator
H4CHR_00681	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4CHR_00682	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H4CHR_00687	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_00698	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_00702	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_00709	COG2268	Band 7 protein
H4CHR_00710	COG5564	TIM-barrel signal transduction protein
H4CHR_00711	COG5441	Belongs to the UPF0261 family
H4CHR_00717	COG1228	amidohydrolase
H4CHR_00718	COG1228	amidohydrolase
H4CHR_00719	COG0596	Alpha beta hydrolase
H4CHR_00720	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_00726	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4CHR_00727	COG1652	LysM domain
H4CHR_00732	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4CHR_00740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_00741	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4CHR_00743	COG0640	Transcriptional regulator
H4CHR_00746	COG0625	glutathione transferase activity
H4CHR_00747	COG0583	DNA-binding transcription factor activity
H4CHR_00748	COG1131	(ABC) transporter
H4CHR_00749	COG0842	Transport permease protein
H4CHR_00751	COG2733	membrane
H4CHR_00753	COG1473	amidohydrolase
H4CHR_00756	COG0243	molybdopterin cofactor binding
H4CHR_00769	COG1216	Glycosyl transferase, family 2
H4CHR_00772	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H4CHR_00773	COG1216	Glycosyl transferase, family 2
H4CHR_00773	COG0438	transferase activity, transferring glycosyl groups
H4CHR_00777	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H4CHR_00777	COG0662	Cupin 2, conserved barrel domain protein
H4CHR_00778	COG2755	lipolytic protein G-D-S-L family
H4CHR_00778	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H4CHR_00779	COG0438	transferase activity, transferring glycosyl groups
H4CHR_00779	COG1216	Glycosyl transferase, family 2
H4CHR_00783	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4CHR_00785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4CHR_00786	COG1309	transcriptional regulator
H4CHR_00790	COG1280	lysine exporter protein (LysE YggA)
H4CHR_00793	COG0628	permease
H4CHR_00796	COG0861	Integral membrane protein TerC family
H4CHR_00802	COG3321	synthase
H4CHR_00802	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00802	COG0604	alcohol dehydrogenase
H4CHR_00803	COG4977	sequence-specific DNA binding
H4CHR_00803	COG1917	Cupin 2, conserved barrel domain protein
H4CHR_00805	COG0625	glutathione transferase activity
H4CHR_00808	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H4CHR_00809	COG2205	protein histidine kinase activity
H4CHR_00809	COG0784	Response regulator, receiver
H4CHR_00810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H4CHR_00811	COG2721	sulfolactate sulfo-lyase activity
H4CHR_00812	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4CHR_00814	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_00815	COG2186	Transcriptional regulator
H4CHR_00816	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00817	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_00818	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_00821	COG2188	Transcriptional regulator
H4CHR_00827	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00828	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4CHR_00829	COG0066	3-isopropylmalate dehydratase activity
H4CHR_00839	COG1960	acyl-CoA dehydrogenase activity
H4CHR_00841	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4CHR_00841	COG1024	Enoyl-CoA hydratase
H4CHR_00843	COG0183	Belongs to the thiolase family
H4CHR_00845	COG1024	Enoyl-CoA hydratase
H4CHR_00846	COG1607	acyl-coa hydrolase
H4CHR_00847	COG5265	(ABC) transporter
H4CHR_00848	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4CHR_00850	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_00851	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4CHR_00852	COG0411	ABC transporter
H4CHR_00854	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_00855	COG3473	Maleate cis-trans isomerase
H4CHR_00856	COG0596	Alpha beta hydrolase
H4CHR_00857	COG2309	aminopeptidase activity
H4CHR_00858	COG1335	isochorismatase
H4CHR_00860	COG0583	DNA-binding transcription factor activity
H4CHR_00862	COG0765	amino acid transport
H4CHR_00863	COG0765	amino acid transport
H4CHR_00864	COG1126	abc transporter atp-binding protein
H4CHR_00865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_00868	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_00869	COG1960	acyl-CoA dehydrogenase activity
H4CHR_00870	COG1960	acyl-CoA dehydrogenase activity
H4CHR_00871	COG0183	Belongs to the thiolase family
H4CHR_00873	COG0583	DNA-binding transcription factor activity
H4CHR_00878	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4CHR_00879	COG3386	PFAM SMP-30 Gluconolaconase
H4CHR_00883	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4CHR_00884	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4CHR_00888	COG0583	DNA-binding transcription factor activity
H4CHR_00891	COG0418	dihydroorotase activity
H4CHR_00899	COG1414	Transcriptional regulator
H4CHR_00900	COG0501	Belongs to the peptidase M48B family
H4CHR_00901	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H4CHR_00903	COG1187	pseudouridine synthase activity
H4CHR_00905	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00911	COG0330	HflC and HflK could
H4CHR_00912	COG0598	Magnesium transport protein CorA
H4CHR_00915	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_00921	COG2072	flavoprotein involved in K transport
H4CHR_00923	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4CHR_00926	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4CHR_00927	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4CHR_00928	COG0523	cobalamin synthesis protein
H4CHR_00931	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H4CHR_00932	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H4CHR_00933	COG2001	Belongs to the MraZ family
H4CHR_00934	COG0275	rRNA processing
H4CHR_00938	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4CHR_00939	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4CHR_00940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4CHR_00941	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4CHR_00942	COG0772	Belongs to the SEDS family
H4CHR_00943	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4CHR_00944	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4CHR_00945	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4CHR_00946	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4CHR_00948	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4CHR_00949	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H4CHR_00951	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4CHR_00953	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
H4CHR_00954	COG1595	DNA-templated transcription, initiation
H4CHR_00958	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H4CHR_00959	COG0575	Belongs to the CDS family
H4CHR_00969	COG3246	L-lysine catabolic process to acetate
H4CHR_00970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4CHR_00972	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4CHR_00975	COG3150	esterase
H4CHR_00976	COG0772	Belongs to the SEDS family
H4CHR_00977	COG0312	modulator of DNA gyrase
H4CHR_00978	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4CHR_00980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4CHR_00982	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4CHR_00983	COG0511	ligase activity, forming carbon-carbon bonds
H4CHR_00984	COG0439	Biotin carboxylase
H4CHR_00985	COG2264	protein methyltransferase activity
H4CHR_00987	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4CHR_00989	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4CHR_00996	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4CHR_00998	COG2204	response regulator
H4CHR_01000	COG2205	protein histidine kinase activity
H4CHR_01001	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4CHR_01003	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4CHR_01004	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4CHR_01013	COG0037	tRNA processing
H4CHR_01015	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_01017	COG2175	clavaminate synthase activity
H4CHR_01025	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_01026	COG0583	DNA-binding transcription factor activity
H4CHR_01027	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4CHR_01029	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H4CHR_01030	COG3387	PFAM Glycoside hydrolase 15-related
H4CHR_01032	COG0617	tRNA 3'-terminal CCA addition
H4CHR_01034	COG1285	pathogenesis
H4CHR_01035	COG0739	heme binding
H4CHR_01035	COG0741	lytic transglycosylase activity
H4CHR_01035	COG1196	nuclear chromosome segregation
H4CHR_01036	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4CHR_01037	COG0583	DNA-binding transcription factor activity
H4CHR_01040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4CHR_01044	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4CHR_01048	COG1053	succinate dehydrogenase
H4CHR_01049	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_01057	COG0477	Major facilitator Superfamily
H4CHR_01058	COG0697	spore germination
H4CHR_01059	COG1902	pentaerythritol trinitrate reductase activity
H4CHR_01062	COG4221	oxidoreductase activity
H4CHR_01066	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01068	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4CHR_01069	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4CHR_01071	COG0583	DNA-binding transcription factor activity
H4CHR_01074	COG2081	HI0933 family
H4CHR_01076	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4CHR_01077	COG0596	Alpha beta hydrolase
H4CHR_01082	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01085	COG3971	2-oxopent-4-enoate hydratase activity
H4CHR_01091	COG0477	Major facilitator Superfamily
H4CHR_01094	COG0596	Alpha beta hydrolase
H4CHR_01103	COG2309	aminopeptidase activity
H4CHR_01104	COG1335	isochorismatase
H4CHR_01106	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_01111	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01113	COG1024	Enoyl-CoA hydratase
H4CHR_01115	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01117	COG0183	Belongs to the thiolase family
H4CHR_01121	COG2207	Transcriptional regulator
H4CHR_01126	COG0583	DNA-binding transcription factor activity
H4CHR_01127	COG1335	isochorismatase
H4CHR_01129	COG2080	2 iron, 2 sulfur cluster binding
H4CHR_01133	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01135	COG2309	aminopeptidase activity
H4CHR_01136	COG0596	Alpha beta hydrolase
H4CHR_01138	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H4CHR_01142	COG1301	dicarboxylic acid transport
H4CHR_01143	COG0583	DNA-binding transcription factor activity
H4CHR_01145	COG2828	Protein conserved in bacteria
H4CHR_01146	COG0583	DNA-binding transcription factor activity
H4CHR_01149	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H4CHR_01151	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4CHR_01152	COG0523	cobalamin synthesis protein
H4CHR_01156	COG2233	PERMEase
H4CHR_01178	COG0683	leucine binding
H4CHR_01180	COG0633	Ferredoxin
H4CHR_01184	COG0583	DNA-binding transcription factor activity
H4CHR_01185	COG2910	NAD(P)H-binding
H4CHR_01191	COG3483	tryptophan 2,3-dioxygenase activity
H4CHR_01193	COG0154	amidase activity
H4CHR_01195	COG0583	DNA-binding transcription factor activity
H4CHR_01197	COG0346	lactoylglutathione lyase activity
H4CHR_01198	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4CHR_01202	COG0154	amidase activity
H4CHR_01204	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4CHR_01207	COG2207	Transcriptional regulator
H4CHR_01208	COG2208	phosphoserine phosphatase activity
H4CHR_01212	COG2172	sigma factor antagonist activity
H4CHR_01219	COG3038	cytochrome b561
H4CHR_01220	COG2814	Major facilitator Superfamily
H4CHR_01221	COG0583	DNA-binding transcription factor activity
H4CHR_01224	COG1640	4-alpha-glucanotransferase
H4CHR_01225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4CHR_01227	COG0668	transmembrane transport
H4CHR_01228	COG0366	Alpha amylase catalytic
H4CHR_01229	COG0366	Alpha amylase catalytic
H4CHR_01230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4CHR_01236	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4CHR_01236	COG0189	ligase activity
H4CHR_01237	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4CHR_01237	COG0189	ligase activity
H4CHR_01238	COG1132	(ABC) transporter
H4CHR_01240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4CHR_01241	COG4178	(ABC) transporter
H4CHR_01256	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4CHR_01258	COG1765	OsmC-like protein
H4CHR_01259	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H4CHR_01262	COG1473	amidohydrolase
H4CHR_01263	COG0747	negative chemotaxis
H4CHR_01264	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4CHR_01265	COG0444	Belongs to the ABC transporter superfamily
H4CHR_01266	COG4608	Belongs to the ABC transporter superfamily
H4CHR_01267	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4CHR_01270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4CHR_01271	COG0166	Belongs to the GPI family
H4CHR_01273	COG0459	protein refolding
H4CHR_01274	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H4CHR_01278	COG4772	TonB-dependent receptor
H4CHR_01280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4CHR_01282	COG1560	Kdo2-lipid A biosynthetic process
H4CHR_01284	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4CHR_01286	COG1333	cytochrome c biogenesis protein
H4CHR_01287	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4CHR_01288	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4CHR_01289	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H4CHR_01291	COG1965	Belongs to the frataxin family
H4CHR_01298	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4CHR_01300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H4CHR_01305	COG0067	glutamate synthase
H4CHR_01305	COG0070	glutamate synthase
H4CHR_01305	COG0069	glutamate synthase activity
H4CHR_01307	COG1127	ABC transporter
H4CHR_01308	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4CHR_01309	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4CHR_01310	COG2853	Lipoprotein
H4CHR_01313	COG1131	(ABC) transporter
H4CHR_01314	COG0842	Transport permease protein
H4CHR_01315	COG5007	Belongs to the BolA IbaG family
H4CHR_01316	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4CHR_01317	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4CHR_01320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4CHR_01321	COG0131	Imidazoleglycerol-phosphate dehydratase
H4CHR_01322	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4CHR_01323	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4CHR_01326	COG0107	imidazoleglycerol-phosphate synthase activity
H4CHR_01327	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4CHR_01328	COG0140	phosphoribosyl-ATP diphosphatase activity
H4CHR_01330	COG0537	adenosine 5'-monophosphoramidase activity
H4CHR_01331	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4CHR_01332	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4CHR_01333	COG0805	protein transport
H4CHR_01334	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_01335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4CHR_01336	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4CHR_01337	COG1970	mechanosensitive ion channel activity
H4CHR_01338	COG0723	plastoquinol--plastocyanin reductase activity
H4CHR_01339	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4CHR_01340	COG2857	Cytochrome c1
H4CHR_01341	COG0625	glutathione transferase activity
H4CHR_01342	COG2969	positive regulation of protein catabolic process
H4CHR_01345	COG0798	PFAM Bile acid sodium symporter
H4CHR_01346	COG0431	NADPH-dependent FMN reductase
H4CHR_01349	COG2860	membrane
H4CHR_01355	COG0653	protein targeting
H4CHR_01358	COG0494	nUDIX hydrolase
H4CHR_01359	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H4CHR_01360	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H4CHR_01362	COG1696	Membrane protein involved in D-alanine export
H4CHR_01364	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H4CHR_01368	COG0438	transferase activity, transferring glycosyl groups
H4CHR_01372	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4CHR_01374	COG1686	Belongs to the peptidase S11 family
H4CHR_01377	COG0463	Glycosyl transferase, family 2
H4CHR_01378	COG0165	Argininosuccinate lyase
H4CHR_01379	COG3275	phosphorelay sensor kinase activity
H4CHR_01381	COG0628	permease
H4CHR_01383	COG0477	Major facilitator Superfamily
H4CHR_01390	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_01391	COG1063	alcohol dehydrogenase
H4CHR_01394	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4CHR_01400	COG4948	Mandelate Racemase Muconate Lactonizing
H4CHR_01404	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4CHR_01409	COG0142	geranyltranstransferase activity
H4CHR_01410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H4CHR_01411	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4CHR_01412	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4CHR_01413	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H4CHR_01415	COG0494	nUDIX hydrolase
H4CHR_01416	COG0442	prolyl-tRNA aminoacylation
H4CHR_01417	COG0741	lytic transglycosylase activity
H4CHR_01418	COG1253	flavin adenine dinucleotide binding
H4CHR_01419	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4CHR_01421	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4CHR_01422	COG2890	protein-(glutamine-N5) methyltransferase activity
H4CHR_01423	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4CHR_01424	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H4CHR_01426	COG3264	Mechanosensitive ion channel
H4CHR_01426	COG1196	nuclear chromosome segregation
H4CHR_01427	COG0584	glycerophosphoryl diester phosphodiesterase
H4CHR_01428	COG3842	ATPase activity
H4CHR_01429	COG0395	ABC-type sugar transport system, permease component
H4CHR_01430	COG1175	transmembrane transport
H4CHR_01432	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4CHR_01436	COG2226	methyltransferase
H4CHR_01439	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4CHR_01440	COG4145	pantothenate transmembrane transporter activity
H4CHR_01443	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4CHR_01444	COG0494	nUDIX hydrolase
H4CHR_01446	COG0302	gtp cyclohydrolase
H4CHR_01453	COG5487	UPF0391 membrane protein
H4CHR_01454	COG4585	Histidine kinase
H4CHR_01455	COG2197	response regulator
H4CHR_01458	COG2982	Protein involved in outer membrane biogenesis
H4CHR_01459	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4CHR_01460	COG0793	Belongs to the peptidase S41A family
H4CHR_01461	COG0588	phosphoglycerate mutase activity
H4CHR_01462	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4CHR_01464	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H4CHR_01465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4CHR_01467	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4CHR_01469	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H4CHR_01470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H4CHR_01471	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4CHR_01472	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4CHR_01476	COG0659	secondary active sulfate transmembrane transporter activity
H4CHR_01478	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4CHR_01478	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4CHR_01479	COG3132	Protein of unknown function, DUF480
H4CHR_01481	COG0583	DNA-binding transcription factor activity
H4CHR_01482	COG0489	protein tyrosine kinase activity
H4CHR_01487	COG3383	formate dehydrogenase (NAD+) activity
H4CHR_01488	COG0463	Glycosyl transferase, family 2
H4CHR_01489	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H4CHR_01497	COG0437	4 iron, 4 sulfur cluster binding
H4CHR_01501	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4CHR_01503	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H4CHR_01505	COG0626	cystathionine gamma-synthase activity
H4CHR_01506	COG1414	Transcriptional regulator
H4CHR_01507	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4CHR_01508	COG2376	Dihydroxyacetone kinase
H4CHR_01510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_01511	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4CHR_01512	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4CHR_01513	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_01514	COG0445	tRNA wobble uridine modification
H4CHR_01519	COG0277	FAD linked oxidase domain protein
H4CHR_01522	COG0247	lactate metabolic process
H4CHR_01523	COG1592	Rubrerythrin
H4CHR_01524	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
H4CHR_01528	COG2003	Belongs to the UPF0758 family
H4CHR_01529	COG1047	Peptidyl-prolyl cis-trans
H4CHR_01530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4CHR_01531	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4CHR_01533	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H4CHR_01535	COG0582	viral genome integration into host DNA
H4CHR_01594	COG1960	acyl-CoA dehydrogenase activity
H4CHR_01595	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H4CHR_01596	COG1960	acyl-CoA dehydrogenase activity
H4CHR_01597	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_01598	COG0427	acetyl-CoA hydrolase
H4CHR_01599	COG0183	Belongs to the thiolase family
H4CHR_01600	COG2030	dehydratase
H4CHR_01606	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4CHR_01610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_01612	COG1902	pentaerythritol trinitrate reductase activity
H4CHR_01613	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_01614	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H4CHR_01624	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_01625	COG2239	Acts as a magnesium transporter
H4CHR_01626	COG2902	Dehydrogenase
H4CHR_01628	COG5002	protein histidine kinase activity
H4CHR_01630	COG0180	Tryptophanyl-tRNA synthetase
H4CHR_01631	COG1994	Peptidase M50
H4CHR_01632	COG0009	L-threonylcarbamoyladenylate synthase
H4CHR_01634	COG0613	PHP domain protein
H4CHR_01640	COG1129	ABC transporter
H4CHR_01644	COG0477	Major facilitator Superfamily
H4CHR_01645	COG0829	nickel cation binding
H4CHR_01653	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4CHR_01661	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4CHR_01661	COG0515	serine threonine protein kinase
H4CHR_01662	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4CHR_01669	COG0392	lysyltransferase activity
H4CHR_01672	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_01673	COG1116	anion transmembrane transporter activity
H4CHR_01675	COG0280	phosphate acetyltransferase
H4CHR_01675	COG0281	malic enzyme
H4CHR_01677	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_01678	COG0583	DNA-binding transcription factor activity
H4CHR_01680	COG0625	glutathione transferase activity
H4CHR_01681	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_01687	COG1477	protein flavinylation
H4CHR_01688	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4CHR_01690	COG3128	pkhd-type hydroxylase
H4CHR_01691	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01696	COG3485	protocatechuate 3,4-dioxygenase
H4CHR_01697	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_01705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4CHR_01709	COG3473	Maleate cis-trans isomerase
H4CHR_01713	COG1021	2,3-dihydroxybenzoate-AMP ligase
H4CHR_01717	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4CHR_01718	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4CHR_01720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_01735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4CHR_01736	COG0066	3-isopropylmalate dehydratase activity
H4CHR_01737	COG2828	Protein conserved in bacteria
H4CHR_01742	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4CHR_01743	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_01745	COG0583	DNA-binding transcription factor activity
H4CHR_01750	COG4608	Belongs to the ABC transporter superfamily
H4CHR_01752	COG4608	Belongs to the ABC transporter superfamily
H4CHR_01754	COG0444	Belongs to the ABC transporter superfamily
H4CHR_01759	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4CHR_01761	COG4521	taurine ABC transporter
H4CHR_01762	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H4CHR_01763	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_01764	COG0625	glutathione transferase activity
H4CHR_01768	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H4CHR_01769	COG1414	Transcriptional regulator
H4CHR_01774	COG1960	acyl-CoA dehydrogenase activity
H4CHR_01775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4CHR_01775	COG1042	CoA-binding domain protein
H4CHR_01775	COG0045	succinate-CoA ligase (ADP-forming) activity
H4CHR_01779	COG0583	DNA-binding transcription factor activity
H4CHR_01781	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_01782	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_01784	COG1414	Transcriptional regulator
H4CHR_01789	COG4964	Belongs to the GSP D family
H4CHR_01799	COG2197	response regulator
H4CHR_01800	COG4585	Histidine kinase
H4CHR_01804	COG1414	Transcriptional regulator
H4CHR_01807	COG0583	DNA-binding transcription factor activity
H4CHR_01808	COG0243	molybdopterin cofactor binding
H4CHR_01809	COG0437	4 iron, 4 sulfur cluster binding
H4CHR_01810	COG3302	dmso reductase anchor subunit
H4CHR_01819	COG0492	ferredoxin-NADP+ reductase activity
H4CHR_01824	COG1126	abc transporter atp-binding protein
H4CHR_01829	COG2304	oxidoreductase activity
H4CHR_01836	COG1815	bacterial-type flagellum-dependent cell motility
H4CHR_01839	COG1749	Flagellar hook protein flgE
H4CHR_01840	COG4787	bacterial-type flagellum-dependent cell motility
H4CHR_01842	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H4CHR_01843	COG1706	bacterial-type flagellum-dependent cell motility
H4CHR_01844	COG3951	Flagellar rod assembly protein muramidase FlgJ
H4CHR_01844	COG1705	Flagellar rod assembly protein muramidase FlgJ
H4CHR_01845	COG0840	transmembrane signaling receptor activity
H4CHR_01846	COG0835	chemotaxis
H4CHR_01848	COG0840	transmembrane signaling receptor activity
H4CHR_01850	COG0840	transmembrane signaling receptor activity
H4CHR_01851	COG1256	bacterial-type flagellum assembly
H4CHR_01856	COG2020	methyltransferase activity
H4CHR_01857	COG2267	carboxylic ester hydrolase activity
H4CHR_01860	COG0432	Pfam Uncharacterised protein family UPF0047
H4CHR_01875	COG1338	Plays a role in the flagellum-specific transport system
H4CHR_01877	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4CHR_01878	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4CHR_01879	COG1580	Controls the rotational direction of flagella during chemotaxis
H4CHR_01882	COG1157	protein secretion by the type III secretion system
H4CHR_01884	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4CHR_01885	COG1766	The M ring may be actively involved in energy transduction
H4CHR_01886	COG1677	Flagellar hook-basal body complex protein FliE
H4CHR_01888	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4CHR_01892	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4CHR_01898	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H4CHR_01899	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4CHR_01900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H4CHR_01903	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H4CHR_01913	COG1716	ATPase activity
H4CHR_01914	COG4251	negative regulation of phosphorylation
H4CHR_01915	COG4251	negative regulation of phosphorylation
H4CHR_01917	COG1484	DNA-dependent DNA replication
H4CHR_01918	COG4584	PFAM Integrase catalytic
H4CHR_01925	COG4669	(LipO)protein
H4CHR_01940	COG4792	protein secretion
H4CHR_01941	COG4791	protein targeting
H4CHR_01942	COG4794	Type iii secretion
H4CHR_01943	COG4790	Type iii secretion
H4CHR_01953	COG4789	Type iii secretion
H4CHR_01958	COG0784	Response regulator, receiver
H4CHR_01959	COG0784	Response regulator, receiver
H4CHR_01959	COG2205	protein histidine kinase activity
H4CHR_01960	COG0129	dihydroxy-acid dehydratase activity
H4CHR_01965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4CHR_01966	COG4569	acetaldehyde dehydrogenase (acetylating) activity
H4CHR_01968	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_01973	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4CHR_01974	COG0308	aminopeptidase N
H4CHR_01975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H4CHR_01977	COG0667	Aldo Keto reductase
H4CHR_01978	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4CHR_01979	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H4CHR_01980	COG0251	oxidation-reduction process
H4CHR_01982	COG1666	GTP binding
H4CHR_01983	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4CHR_01984	COG0137	argininosuccinate synthase activity
H4CHR_01985	COG3123	guanosine phosphorylase activity
H4CHR_01987	COG1393	Belongs to the ArsC family
H4CHR_01988	COG0285	dihydrofolate synthase activity
H4CHR_01993	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4CHR_01999	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02000	COG0183	Belongs to the thiolase family
H4CHR_02003	COG0300	oxidoreductase activity
H4CHR_02004	COG2207	Transcriptional regulator
H4CHR_02007	COG0583	DNA-binding transcription factor activity
H4CHR_02008	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_02009	COG1024	Enoyl-CoA hydratase
H4CHR_02012	COG1921	L-seryl-tRNASec selenium transferase activity
H4CHR_02014	COG0492	ferredoxin-NADP+ reductase activity
H4CHR_02019	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02020	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02021	COG1053	succinate dehydrogenase
H4CHR_02021	COG3976	FMN-binding domain protein
H4CHR_02022	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02025	COG1053	succinate dehydrogenase
H4CHR_02027	COG2188	Transcriptional regulator
H4CHR_02028	COG0683	leucine binding
H4CHR_02031	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_02037	COG0583	DNA-binding transcription factor activity
H4CHR_02040	COG0492	ferredoxin-NADP+ reductase activity
H4CHR_02043	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4CHR_02045	COG2252	PERMEase
H4CHR_02050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4CHR_02053	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4CHR_02054	COG2199	diguanylate cyclase activity
H4CHR_02054	COG2200	EAL domain
H4CHR_02054	COG3287	FIST C domain
H4CHR_02058	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_02059	COG0717	Belongs to the dCTP deaminase family
H4CHR_02060	COG2321	neutral zinc metallopeptidase
H4CHR_02061	COG0513	Belongs to the DEAD box helicase family
H4CHR_02062	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4CHR_02063	COG1253	flavin adenine dinucleotide binding
H4CHR_02067	COG2084	Dehydrogenase
H4CHR_02068	COG3622	Belongs to the hyi family
H4CHR_02069	COG3960	tartronate-semialdehyde synthase activity
H4CHR_02070	COG0583	DNA-binding transcription factor activity
H4CHR_02073	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4CHR_02074	COG1335	isochorismatase
H4CHR_02075	COG0251	oxidation-reduction process
H4CHR_02076	COG2267	carboxylic ester hydrolase activity
H4CHR_02077	COG0778	Nitroreductase
H4CHR_02078	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4CHR_02079	COG1309	transcriptional regulator
H4CHR_02081	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4CHR_02082	COG3842	ATPase activity
H4CHR_02083	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4CHR_02084	COG1177	transmembrane transport
H4CHR_02086	COG2186	Transcriptional regulator
H4CHR_02087	COG1301	dicarboxylic acid transport
H4CHR_02089	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4CHR_02091	COG1064	alcohol dehydrogenase
H4CHR_02095	COG2267	carboxylic ester hydrolase activity
H4CHR_02098	COG1902	pentaerythritol trinitrate reductase activity
H4CHR_02100	COG0583	DNA-binding transcription factor activity
H4CHR_02103	COG1959	2 iron, 2 sulfur cluster binding
H4CHR_02108	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H4CHR_02109	COG1960	acyl-CoA dehydrogenase activity
H4CHR_02111	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4CHR_02115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4CHR_02117	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4CHR_02118	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02119	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02126	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02128	COG1309	transcriptional regulator
H4CHR_02129	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02133	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_02137	COG0604	alcohol dehydrogenase
H4CHR_02138	COG2130	NADP-dependent
H4CHR_02143	COG1024	Enoyl-CoA hydratase
H4CHR_02147	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H4CHR_02154	COG0277	FAD linked oxidase domain protein
H4CHR_02155	COG1522	sequence-specific DNA binding
H4CHR_02159	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4CHR_02167	COG3901	Regulator of nitric oxide reductase transcription
H4CHR_02167	COG0348	domain, Protein
H4CHR_02172	COG1129	ABC transporter
H4CHR_02172	COG0842	Transport permease protein
H4CHR_02173	COG0535	radical SAM domain protein
H4CHR_02176	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H4CHR_02182	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_02183	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02187	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H4CHR_02189	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02192	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_02199	COG0596	Alpha beta hydrolase
H4CHR_02202	COG0730	response to heat
H4CHR_02209	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_02212	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02213	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4CHR_02222	COG0667	Aldo Keto reductase
H4CHR_02223	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02224	COG0277	FAD linked oxidase domain protein
H4CHR_02225	COG3119	arylsulfatase activity
H4CHR_02226	COG0583	DNA-binding transcription factor activity
H4CHR_02230	COG4948	Mandelate Racemase Muconate Lactonizing
H4CHR_02231	COG0583	DNA-binding transcription factor activity
H4CHR_02235	COG2030	dehydratase
H4CHR_02236	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02237	COG1960	acyl-CoA dehydrogenase activity
H4CHR_02238	COG1960	acyl-CoA dehydrogenase activity
H4CHR_02239	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02240	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02241	COG0028	Belongs to the TPP enzyme family
H4CHR_02243	COG0583	DNA-binding transcription factor activity
H4CHR_02247	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4CHR_02251	COG0154	amidase activity
H4CHR_02252	COG0583	DNA-binding transcription factor activity
H4CHR_02253	COG0251	oxidation-reduction process
H4CHR_02259	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4CHR_02265	COG1793	dna ligase
H4CHR_02266	COG0784	Response regulator, receiver
H4CHR_02266	COG4191	Histidine kinase
H4CHR_02275	COG0745	RESPONSE REGULATOR receiver
H4CHR_02277	COG2205	protein histidine kinase activity
H4CHR_02278	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4CHR_02284	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4CHR_02285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H4CHR_02286	COG2080	2 iron, 2 sulfur cluster binding
H4CHR_02288	COG2814	Major facilitator Superfamily
H4CHR_02289	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4CHR_02290	COG0656	L-ascorbic acid biosynthetic process
H4CHR_02291	COG2233	PERMEase
H4CHR_02295	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02297	COG3754	Rhamnan synthesis protein F
H4CHR_02298	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4CHR_02301	COG2186	Transcriptional regulator
H4CHR_02302	COG2351	hydroxyisourate hydrolase activity
H4CHR_02307	COG0583	DNA-binding transcription factor activity
H4CHR_02312	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_02315	COG1131	(ABC) transporter
H4CHR_02316	COG0842	Transport permease protein
H4CHR_02317	COG0842	Transport permease protein
H4CHR_02323	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H4CHR_02323	COG0674	pyruvate-flavodoxin oxidoreductase activity
H4CHR_02328	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_02329	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4CHR_02331	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02336	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02342	COG0515	serine threonine protein kinase
H4CHR_02363	COG1414	Transcriptional regulator
H4CHR_02367	COG1024	Enoyl-CoA hydratase
H4CHR_02369	COG2831	hemolysin activation secretion protein
H4CHR_02370	COG3210	domain, Protein
H4CHR_02375	COG2217	Heavy metal translocating P-type atpase
H4CHR_02376	COG0789	Transcriptional regulator
H4CHR_02377	COG2010	Cytochrome c
H4CHR_02377	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4CHR_02380	COG0697	spore germination
H4CHR_02381	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4CHR_02382	COG2169	Transcriptional regulator
H4CHR_02389	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4CHR_02393	COG1309	transcriptional regulator
H4CHR_02394	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4CHR_02397	COG0527	aspartate kinase activity
H4CHR_02398	COG0667	Aldo Keto reductase
H4CHR_02400	COG0259	pyridoxamine-phosphate oxidase activity
H4CHR_02401	COG0583	DNA-binding transcription factor activity
H4CHR_02406	COG0800	Aldolase
H4CHR_02408	COG0346	lactoylglutathione lyase activity
H4CHR_02412	COG1840	ABC-type Fe3 transport system, periplasmic component
H4CHR_02413	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02414	COG2070	2-Nitropropane dioxygenase
H4CHR_02425	COG4221	oxidoreductase activity
H4CHR_02427	COG0800	Aldolase
H4CHR_02429	COG0129	dihydroxy-acid dehydratase activity
H4CHR_02430	COG2186	Transcriptional regulator
H4CHR_02432	COG1175	transmembrane transport
H4CHR_02434	COG3842	ATPase activity
H4CHR_02437	COG0513	Belongs to the DEAD box helicase family
H4CHR_02439	COG0488	(ABC) transporter
H4CHR_02442	COG3191	aminopeptidase activity
H4CHR_02445	COG0584	glycerophosphoryl diester phosphodiesterase
H4CHR_02448	COG0765	amino acid transport
H4CHR_02449	COG0765	amino acid transport
H4CHR_02452	COG1764	response to oxidative stress
H4CHR_02453	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02455	COG0456	acetyltransferase
H4CHR_02457	COG1252	NADH dehydrogenase
H4CHR_02458	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4CHR_02459	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H4CHR_02462	COG0589	response to stress
H4CHR_02463	COG0564	pseudouridine synthase activity
H4CHR_02465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4CHR_02468	COG2354	Protein conserved in bacteria
H4CHR_02469	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H4CHR_02472	COG3468	outer membrane autotransporter barrel domain protein
H4CHR_02475	COG0400	carboxylic ester hydrolase activity
H4CHR_02476	COG2918	glutathione biosynthetic process
H4CHR_02477	COG2423	ornithine cyclodeaminase activity
H4CHR_02480	COG3279	Response regulator of the LytR AlgR family
H4CHR_02486	COG2175	clavaminate synthase activity
H4CHR_02487	COG1454	alcohol dehydrogenase
H4CHR_02489	COG0583	DNA-binding transcription factor activity
H4CHR_02490	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_02491	COG3246	L-lysine catabolic process to acetate
H4CHR_02492	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_02495	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02495	COG3321	synthase
H4CHR_02495	COG0604	alcohol dehydrogenase
H4CHR_02504	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4CHR_02506	COG3279	Response regulator of the LytR AlgR family
H4CHR_02507	COG3275	phosphorelay sensor kinase activity
H4CHR_02511	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4CHR_02515	COG1968	undecaprenyl-diphosphatase activity
H4CHR_02520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H4CHR_02522	COG3119	arylsulfatase activity
H4CHR_02528	COG1289	transmembrane transporter activity
H4CHR_02531	COG1045	serine acetyltransferase
H4CHR_02532	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4CHR_02533	COG3028	Belongs to the UPF0307 family
H4CHR_02534	COG0312	modulator of DNA gyrase
H4CHR_02536	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4CHR_02537	COG2081	HI0933 family
H4CHR_02540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4CHR_02541	COG0243	molybdopterin cofactor binding
H4CHR_02543	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4CHR_02545	COG2223	nitrite transmembrane transporter activity
H4CHR_02547	COG1116	anion transmembrane transporter activity
H4CHR_02548	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_02549	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4CHR_02550	COG3707	response regulator
H4CHR_02551	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4CHR_02553	COG0071	Belongs to the small heat shock protein (HSP20) family
H4CHR_02554	COG0683	leucine binding
H4CHR_02555	COG0436	Aminotransferase
H4CHR_02556	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4CHR_02557	COG1185	polyribonucleotide nucleotidyltransferase activity
H4CHR_02559	COG0149	triose-phosphate isomerase activity
H4CHR_02562	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4CHR_02563	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4CHR_02564	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4CHR_02565	COG0649	NAD binding
H4CHR_02568	COG1034	ATP synthesis coupled electron transport
H4CHR_02569	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4CHR_02570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4CHR_02572	COG0713	ATP synthesis coupled electron transport
H4CHR_02575	COG1007	ATP synthesis coupled electron transport
H4CHR_02577	COG0494	nUDIX hydrolase
H4CHR_02579	COG1132	(ABC) transporter
H4CHR_02580	COG1846	Transcriptional regulator
H4CHR_02582	COG1566	PFAM secretion protein HlyD family protein
H4CHR_02583	COG2814	Major facilitator Superfamily
H4CHR_02592	COG0154	amidase activity
H4CHR_02594	COG0477	Major facilitator Superfamily
H4CHR_02596	COG1215	transferase activity, transferring glycosyl groups
H4CHR_02602	COG3795	YCII-related domain
H4CHR_02603	COG0154	amidase activity
H4CHR_02606	COG2186	Transcriptional regulator
H4CHR_02609	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_02613	COG0366	Alpha amylase catalytic
H4CHR_02617	COG4178	(ABC) transporter
H4CHR_02619	COG1136	(ABC) transporter
H4CHR_02620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4CHR_02622	COG1850	ribulose-bisphosphate carboxylase activity
H4CHR_02624	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4CHR_02625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_02626	COG1609	Transcriptional regulator
H4CHR_02628	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4CHR_02629	COG0586	Pfam SNARE associated Golgi protein
H4CHR_02632	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4CHR_02633	COG0802	atpase or kinase
H4CHR_02634	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4CHR_02637	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02638	COG4974	Belongs to the 'phage' integrase family
H4CHR_02640	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_02641	COG2833	Protein of unknown function (DUF455)
H4CHR_02643	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H4CHR_02645	COG0726	polysaccharide deacetylase
H4CHR_02647	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4CHR_02647	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4CHR_02650	COG2076	Multidrug Resistance protein
H4CHR_02651	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H4CHR_02652	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H4CHR_02653	COG0148	phosphopyruvate hydratase activity
H4CHR_02654	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H4CHR_02655	COG0504	CTP synthase activity
H4CHR_02656	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4CHR_02658	COG0756	dUTP diphosphatase activity
H4CHR_02660	COG1047	Peptidyl-prolyl cis-trans
H4CHR_02661	COG2850	peptidyl-arginine hydroxylation
H4CHR_02664	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H4CHR_02665	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H4CHR_02666	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4CHR_02673	COG0741	lytic transglycosylase activity
H4CHR_02679	COG0765	amino acid transport
H4CHR_02682	COG1126	abc transporter atp-binding protein
H4CHR_02684	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4CHR_02686	COG1609	Transcriptional regulator
H4CHR_02688	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_02690	COG1522	sequence-specific DNA binding
H4CHR_02696	COG2308	Evidence 4 Homologs of previously reported genes of
H4CHR_02705	COG2273	Hydrolase Family 16
H4CHR_02705	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H4CHR_02706	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H4CHR_02709	COG3842	ATPase activity
H4CHR_02710	COG3842	ATPase activity
H4CHR_02713	COG0395	ABC-type sugar transport system, permease component
H4CHR_02717	COG2951	lytic endotransglycosylase activity
H4CHR_02720	COG0714	Associated with various cellular activities
H4CHR_02722	COG3264	Mechanosensitive ion channel
H4CHR_02722	COG1511	domain protein
H4CHR_02725	COG1960	acyl-CoA dehydrogenase activity
H4CHR_02731	COG1294	oxidase, subunit
H4CHR_02732	COG1271	oxidase subunit
H4CHR_02735	COG0784	Response regulator, receiver
H4CHR_02736	COG4191	Histidine kinase
H4CHR_02736	COG0784	Response regulator, receiver
H4CHR_02738	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4CHR_02741	COG0071	Belongs to the small heat shock protein (HSP20) family
H4CHR_02742	COG0477	Major facilitator Superfamily
H4CHR_02745	COG0277	FAD linked oxidase domain protein
H4CHR_02747	COG1414	Transcriptional regulator
H4CHR_02748	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4CHR_02750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4CHR_02759	COG0477	Major facilitator Superfamily
H4CHR_02762	COG4941	Belongs to the sigma-70 factor family
H4CHR_02764	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4CHR_02766	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4CHR_02766	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4CHR_02767	COG0509	glycine decarboxylation via glycine cleavage system
H4CHR_02768	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4CHR_02773	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_02774	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4CHR_02775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4CHR_02775	COG2205	protein histidine kinase activity
H4CHR_02777	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02780	COG0642	Histidine kinase
H4CHR_02781	COG0745	RESPONSE REGULATOR receiver
H4CHR_02783	COG2194	sulfuric ester hydrolase activity
H4CHR_02786	COG4302	ethanolamine ammonia-lyase activity
H4CHR_02787	COG4303	Ethanolamine ammonia lyase large subunit
H4CHR_02788	COG0545	Peptidyl-prolyl cis-trans isomerase
H4CHR_02789	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H4CHR_02790	COG2169	Transcriptional regulator
H4CHR_02790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4CHR_02798	COG2197	response regulator
H4CHR_02807	COG1024	Enoyl-CoA hydratase
H4CHR_02810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4CHR_02817	COG2197	response regulator
H4CHR_02818	COG2197	response regulator
H4CHR_02819	COG2909	trisaccharide binding
H4CHR_02819	COG2909	trisaccharide binding
H4CHR_02821	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_02822	COG1183	phosphatidylcholine synthase activity
H4CHR_02823	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4CHR_02825	COG1132	(ABC) transporter
H4CHR_02826	COG3384	dioxygenase
H4CHR_02831	COG0587	DNA-directed DNA polymerase activity
H4CHR_02835	COG1309	transcriptional regulator
H4CHR_02843	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4CHR_02846	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_02847	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_02851	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_02853	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4CHR_02854	COG0045	succinate-CoA ligase (ADP-forming) activity
H4CHR_02855	COG1024	Enoyl-CoA hydratase
H4CHR_02858	COG1960	acyl-CoA dehydrogenase activity
H4CHR_02859	COG2130	NADP-dependent
H4CHR_02860	COG1960	acyl-CoA dehydrogenase activity
H4CHR_02862	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_02863	COG2070	2-Nitropropane dioxygenase
H4CHR_02864	COG2188	Transcriptional regulator
H4CHR_02867	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4CHR_02871	COG0625	glutathione transferase activity
H4CHR_02883	COG0419	ATPase involved in DNA repair
H4CHR_02891	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4CHR_02891	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4CHR_02971	COG0616	signal peptide processing
H4CHR_03008	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4CHR_03010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4CHR_03012	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4CHR_03016	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03018	COG2267	carboxylic ester hydrolase activity
H4CHR_03019	COG1414	Transcriptional regulator
H4CHR_03020	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03021	COG0028	Belongs to the TPP enzyme family
H4CHR_03022	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H4CHR_03023	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_03026	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_03032	COG0583	DNA-binding transcription factor activity
H4CHR_03033	COG2175	clavaminate synthase activity
H4CHR_03034	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03035	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_03042	COG2217	Heavy metal translocating P-type atpase
H4CHR_03043	COG3278	Belongs to the heme-copper respiratory oxidase family
H4CHR_03051	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4CHR_03055	COG0084	hydrolase, TatD family'
H4CHR_03058	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H4CHR_03059	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4CHR_03061	COG2879	small protein
H4CHR_03062	COG1966	Carbon starvation protein
H4CHR_03073	COG2183	response to ionizing radiation
H4CHR_03074	COG0583	DNA-binding transcription factor activity
H4CHR_03079	COG0534	Mate efflux family protein
H4CHR_03087	COG0477	Major facilitator Superfamily
H4CHR_03088	COG2814	Major facilitator Superfamily
H4CHR_03089	COG2814	Major facilitator Superfamily
H4CHR_03092	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4CHR_03092	COG3008	intermembrane lipid transfer
H4CHR_03093	COG2995	paraquat-inducible protein a
H4CHR_03094	COG2995	paraquat-inducible protein a
H4CHR_03095	COG0583	DNA-binding transcription factor activity
H4CHR_03096	COG2814	Major facilitator Superfamily
H4CHR_03097	COG0667	Aldo Keto reductase
H4CHR_03098	COG0745	RESPONSE REGULATOR receiver
H4CHR_03099	COG0642	Histidine kinase
H4CHR_03101	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4CHR_03102	COG0583	DNA-binding transcription factor activity
H4CHR_03103	COG5507	3-demethylubiquinone-9 3-methyltransferase
H4CHR_03107	COG1960	acyl-CoA dehydrogenase activity
H4CHR_03108	COG2130	NADP-dependent
H4CHR_03112	COG1960	acyl-CoA dehydrogenase activity
H4CHR_03113	COG0183	Belongs to the thiolase family
H4CHR_03114	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4CHR_03115	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4CHR_03115	COG1024	Enoyl-CoA hydratase
H4CHR_03117	COG0411	ABC transporter
H4CHR_03119	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_03121	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_03122	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4CHR_03123	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4CHR_03124	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4CHR_03125	COG2917	probably involved in intracellular septation
H4CHR_03127	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4CHR_03128	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4CHR_03128	COG0047	phosphoribosylformylglycinamidine synthase activity
H4CHR_03129	COG0024	Methionine aminopeptidase
H4CHR_03130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H4CHR_03131	COG2259	Doxx family
H4CHR_03132	COG0242	peptide deformylase activity
H4CHR_03134	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4CHR_03136	COG1196	nuclear chromosome segregation
H4CHR_03143	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4CHR_03144	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4CHR_03145	COG4208	sulfate ABC transporter
H4CHR_03147	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4CHR_03150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4CHR_03152	COG1045	serine acetyltransferase
H4CHR_03153	COG0583	DNA-binding transcription factor activity
H4CHR_03156	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H4CHR_03158	COG0431	NADPH-dependent FMN reductase
H4CHR_03159	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4CHR_03160	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H4CHR_03161	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4CHR_03161	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4CHR_03163	COG1272	protein, Hemolysin III
H4CHR_03165	COG2814	Major facilitator Superfamily
H4CHR_03170	COG2895	sulfate adenylyltransferase (ATP) activity
H4CHR_03171	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4CHR_03172	COG0492	ferredoxin-NADP+ reductase activity
H4CHR_03173	COG0671	phosphoesterase, PA-phosphatase related
H4CHR_03175	COG4654	Cytochrome c, class I
H4CHR_03177	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4CHR_03179	COG0114	fumarate hydratase activity
H4CHR_03188	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4CHR_03189	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4CHR_03190	COG0740	serine-type endopeptidase activity
H4CHR_03191	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4CHR_03194	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4CHR_03197	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H4CHR_03199	COG1011	Hydrolase
H4CHR_03200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4CHR_03208	COG2204	response regulator
H4CHR_03216	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03217	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4CHR_03218	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03219	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4CHR_03220	COG0583	DNA-binding transcription factor activity
H4CHR_03222	COG1024	Enoyl-CoA hydratase
H4CHR_03224	COG1960	acyl-CoA dehydrogenase activity
H4CHR_03227	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03230	COG0437	4 iron, 4 sulfur cluster binding
H4CHR_03239	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4CHR_03242	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4CHR_03246	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03248	COG0642	Histidine kinase
H4CHR_03250	COG2326	polyphosphate kinase activity
H4CHR_03252	COG1414	Transcriptional regulator
H4CHR_03257	COG0527	aspartate kinase activity
H4CHR_03258	COG0037	tRNA processing
H4CHR_03259	COG0825	malonyl-CoA metabolic process
H4CHR_03261	COG0215	cysteine-tRNA ligase activity
H4CHR_03266	COG3228	Belongs to the MtfA family
H4CHR_03269	COG0741	lytic transglycosylase activity
H4CHR_03270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4CHR_03271	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4CHR_03283	COG4968	Prepilin-type N-terminal cleavage methylation domain
H4CHR_03284	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4CHR_03284	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4CHR_03287	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4CHR_03288	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4CHR_03289	COG0436	Aminotransferase
H4CHR_03290	COG0824	Thioesterase
H4CHR_03292	COG0848	biopolymer transport protein
H4CHR_03296	COG1741	Belongs to the pirin family
H4CHR_03298	COG2259	Doxx family
H4CHR_03299	COG1741	Belongs to the pirin family
H4CHR_03301	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4CHR_03301	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4CHR_03302	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4CHR_03303	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4CHR_03304	COG2863	cytochrome
H4CHR_03305	COG2010	Cytochrome c
H4CHR_03305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4CHR_03308	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4CHR_03310	COG1215	transferase activity, transferring glycosyl groups
H4CHR_03311	COG1215	transferase activity, transferring glycosyl groups
H4CHR_03312	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H4CHR_03313	COG0457	Tetratricopeptide repeat
H4CHR_03316	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H4CHR_03318	COG0840	transmembrane signaling receptor activity
H4CHR_03323	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4CHR_03329	COG4566	intracellular signal transduction
H4CHR_03330	COG4191	Histidine kinase
H4CHR_03331	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H4CHR_03332	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03333	COG3246	L-lysine catabolic process to acetate
H4CHR_03337	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_03341	COG2272	Belongs to the type-B carboxylesterase lipase family
H4CHR_03342	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03344	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4CHR_03344	COG0045	succinate-CoA ligase (ADP-forming) activity
H4CHR_03344	COG1042	CoA-binding domain protein
H4CHR_03345	COG2197	response regulator
H4CHR_03348	COG0477	Major facilitator Superfamily
H4CHR_03349	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4CHR_03350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4CHR_03351	COG1845	cytochrome c oxidase, subunit III
H4CHR_03352	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4CHR_03353	COG3346	SURF1 family
H4CHR_03355	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H4CHR_03359	COG0747	negative chemotaxis
H4CHR_03360	COG0601	transmembrane transport
H4CHR_03361	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4CHR_03362	COG0444	Belongs to the ABC transporter superfamily
H4CHR_03363	COG4608	Belongs to the ABC transporter superfamily
H4CHR_03364	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4CHR_03366	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4CHR_03369	COG1840	ABC-type Fe3 transport system, periplasmic component
H4CHR_03371	COG3842	ATPase activity
H4CHR_03372	COG1672	PFAM Archaeal ATPase
H4CHR_03372	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H4CHR_03373	COG2226	methyltransferase
H4CHR_03374	COG0583	DNA-binding transcription factor activity
H4CHR_03379	COG4948	Mandelate Racemase Muconate Lactonizing
H4CHR_03380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4CHR_03382	COG0583	DNA-binding transcription factor activity
H4CHR_03384	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_03386	COG0579	oxidoreductase
H4CHR_03393	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4CHR_03394	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_03401	COG0235	Class ii aldolase
H4CHR_03403	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_03407	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4CHR_03414	COG0583	DNA-binding transcription factor activity
H4CHR_03415	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03416	COG1053	succinate dehydrogenase
H4CHR_03417	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_03420	COG1840	ABC-type Fe3 transport system, periplasmic component
H4CHR_03421	COG3842	ATPase activity
H4CHR_03427	COG0277	FAD linked oxidase domain protein
H4CHR_03428	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4CHR_03431	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03433	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4CHR_03434	COG0084	hydrolase, TatD family'
H4CHR_03435	COG0519	Catalyzes the synthesis of GMP from XMP
H4CHR_03435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4CHR_03439	COG2867	negative regulation of translational initiation
H4CHR_03440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4CHR_03448	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4CHR_03449	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4CHR_03450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H4CHR_03451	COG0195	Participates in both transcription termination and antitermination
H4CHR_03451	COG2251	uridine kinase activity
H4CHR_03452	COG0779	Required for maturation of 30S ribosomal subunits
H4CHR_03453	COG0477	Major facilitator Superfamily
H4CHR_03454	COG4172	Belongs to the ABC transporter superfamily
H4CHR_03455	COG4239	(ABC) transporter, permease
H4CHR_03456	COG4174	ABC transporter (Permease)
H4CHR_03459	COG1793	dna ligase
H4CHR_03460	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4CHR_03462	COG1982	Orn Lys Arg decarboxylase major
H4CHR_03470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4CHR_03474	COG0583	DNA-binding transcription factor activity
H4CHR_03475	COG0436	Aminotransferase
H4CHR_03477	COG1643	Atp-dependent helicase
H4CHR_03478	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H4CHR_03478	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4CHR_03479	COG0436	Aminotransferase
H4CHR_03480	COG2171	N-acyltransferase activity
H4CHR_03482	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4CHR_03483	COG2890	protein-(glutamine-N5) methyltransferase activity
H4CHR_03490	COG3976	FMN-binding domain protein
H4CHR_03490	COG1053	succinate dehydrogenase
H4CHR_03496	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_03502	COG0745	RESPONSE REGULATOR receiver
H4CHR_03503	COG0596	Alpha beta hydrolase
H4CHR_03505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4CHR_03507	COG2885	chlorophyll binding
H4CHR_03508	COG0823	Involved in the tonB-independent uptake of proteins
H4CHR_03509	COG1132	(ABC) transporter
H4CHR_03510	COG1530	ribonuclease E activity
H4CHR_03511	COG0424	maF-like protein
H4CHR_03512	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H4CHR_03513	COG0799	negative regulation of ribosome biogenesis
H4CHR_03514	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4CHR_03515	COG0408	coproporphyrinogen oxidase activity
H4CHR_03516	COG0151	Belongs to the GarS family
H4CHR_03517	COG0217	transcriptional regulatory protein
H4CHR_03529	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4CHR_03532	COG0433	COG0433 Predicted ATPase
H4CHR_03533	COG4944	Protein of unknown function (DUF1109)
H4CHR_03534	COG1595	DNA-templated transcription, initiation
H4CHR_03536	COG3220	belongs to the UPF0276 family
H4CHR_03541	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4CHR_03542	COG1744	ABC transporter substrate-binding protein PnrA-like
H4CHR_03546	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_03547	COG2925	Exonuclease
H4CHR_03548	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_03549	COG0542	response to heat
H4CHR_03550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H4CHR_03554	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4CHR_03555	COG1570	exodeoxyribonuclease VII activity
H4CHR_03556	COG0811	peptide transport
H4CHR_03557	COG0848	biopolymer transport protein
H4CHR_03558	COG1663	tetraacyldisaccharide 4'-kinase activity
H4CHR_03559	COG2835	tetraacyldisaccharide 4'-kinase activity
H4CHR_03560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H4CHR_03561	COG0563	adenylate kinase activity
H4CHR_03564	COG0252	asparaginase activity
H4CHR_03565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4CHR_03567	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4CHR_03568	COG2814	Major facilitator Superfamily
H4CHR_03570	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4CHR_03571	COG1024	Enoyl-CoA hydratase
H4CHR_03576	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4CHR_03578	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4CHR_03579	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H4CHR_03580	COG1534	Rna-binding protein
H4CHR_03583	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4CHR_03585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4CHR_03586	COG0505	Belongs to the CarA family
H4CHR_03587	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4CHR_03588	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4CHR_03589	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4CHR_03590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4CHR_03591	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4CHR_03592	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4CHR_03595	COG0750	zinc metalloprotease
H4CHR_03596	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4CHR_03597	COG0575	Belongs to the CDS family
H4CHR_03598	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4CHR_03599	COG0233	cytoplasmic translational termination
H4CHR_03600	COG0528	UMP kinase activity
H4CHR_03601	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4CHR_03602	COG0052	Belongs to the universal ribosomal protein uS2 family
H4CHR_03604	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4CHR_03605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4CHR_03605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4CHR_03606	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03607	COG0557	exoribonuclease II activity
H4CHR_03609	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4CHR_03610	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H4CHR_03613	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4CHR_03614	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03617	COG0745	RESPONSE REGULATOR receiver
H4CHR_03618	COG2205	protein histidine kinase activity
H4CHR_03619	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4CHR_03619	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4CHR_03620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4CHR_03620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4CHR_03621	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4CHR_03622	COG0560	Phosphoserine phosphatase
H4CHR_03623	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03627	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4CHR_03628	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4CHR_03631	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H4CHR_03632	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4CHR_03633	COG1492	cobalamin metabolic process
H4CHR_03634	COG1538	Outer membrane efflux protein
H4CHR_03636	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4CHR_03639	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4CHR_03641	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H4CHR_03642	COG1120	ATPase activity
H4CHR_03643	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4CHR_03644	COG4607	ABC-type enterochelin transport system periplasmic component
H4CHR_03646	COG4206	TonB-dependent receptor
H4CHR_03649	COG0730	response to heat
H4CHR_03651	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_03655	COG1802	Transcriptional regulator
H4CHR_03657	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4CHR_03658	COG0583	DNA-binding transcription factor activity
H4CHR_03659	COG0129	dihydroxy-acid dehydratase activity
H4CHR_03662	COG0351	phosphomethylpyrimidine kinase
H4CHR_03665	COG2022	thiamine diphosphate biosynthetic process
H4CHR_03677	COG1175	transmembrane transport
H4CHR_03680	COG0246	Mannitol dehydrogenase
H4CHR_03681	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03682	COG4753	response regulator
H4CHR_03682	COG2207	Transcriptional regulator
H4CHR_03683	COG1070	Carbohydrate kinase
H4CHR_03686	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_03687	COG0642	Histidine kinase
H4CHR_03688	COG0745	RESPONSE REGULATOR receiver
H4CHR_03689	COG1414	Transcriptional regulator
H4CHR_03692	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H4CHR_03693	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H4CHR_03694	COG1414	Transcriptional regulator
H4CHR_03696	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4CHR_03697	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4CHR_03698	COG1183	phosphatidylcholine synthase activity
H4CHR_03699	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4CHR_03700	COG0440	acetolactate synthase activity
H4CHR_03701	COG0028	Belongs to the TPP enzyme family
H4CHR_03708	COG0347	Belongs to the P(II) protein family
H4CHR_03710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4CHR_03711	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4CHR_03716	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_03727	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4CHR_03728	COG0746	molybdenum cofactor guanylyltransferase activity
H4CHR_03731	COG0328	RNA-DNA hybrid ribonuclease activity
H4CHR_03733	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4CHR_03734	COG1388	LysM domain
H4CHR_03734	COG0741	lytic transglycosylase activity
H4CHR_03735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_03737	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4CHR_03739	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4CHR_03740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H4CHR_03741	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4CHR_03757	COG1074	ATP-dependent DNA helicase activity
H4CHR_03759	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4CHR_03760	COG0673	inositol 2-dehydrogenase activity
H4CHR_03761	COG0254	rRNA binding
H4CHR_03763	COG0534	Mate efflux family protein
H4CHR_03764	COG5002	protein histidine kinase activity
H4CHR_03767	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4CHR_03768	COG0581	inorganic phosphate transmembrane transporter activity
H4CHR_03769	COG0573	inorganic phosphate transmembrane transporter activity
H4CHR_03770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4CHR_03773	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4CHR_03776	COG0625	glutathione transferase activity
H4CHR_03784	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_03785	COG4948	Mandelate Racemase Muconate Lactonizing
H4CHR_03787	COG1024	Enoyl-CoA hydratase
H4CHR_03788	COG1960	acyl-CoA dehydrogenase activity
H4CHR_03789	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_03793	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H4CHR_03795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_03798	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4CHR_03799	COG0589	response to stress
H4CHR_03800	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4CHR_03802	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03806	COG4191	Histidine kinase
H4CHR_03806	COG0784	Response regulator, receiver
H4CHR_03814	COG1960	acyl-CoA dehydrogenase activity
H4CHR_03815	COG1960	acyl-CoA dehydrogenase activity
H4CHR_03820	COG1024	Enoyl-CoA hydratase
H4CHR_03821	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_03822	COG0028	Belongs to the TPP enzyme family
H4CHR_03829	COG2146	nitrite reductase [NAD(P)H] activity
H4CHR_03833	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H4CHR_03834	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4CHR_03835	COG0045	succinate-CoA ligase (ADP-forming) activity
H4CHR_03835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4CHR_03835	COG1042	CoA-binding domain protein
H4CHR_03838	COG0516	GMP reductase activity
H4CHR_03838	COG0517	IMP dehydrogenase activity
H4CHR_03841	COG2223	nitrite transmembrane transporter activity
H4CHR_03842	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H4CHR_03843	COG1140	nitrate reductase beta subunit
H4CHR_03844	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H4CHR_03845	COG2181	nitrate reductase activity
H4CHR_03851	COG3256	nitric oxide reductase
H4CHR_03852	COG1959	2 iron, 2 sulfur cluster binding
H4CHR_03853	COG2151	metal-sulfur cluster biosynthetic enzyme
H4CHR_03857	COG3162	membrane
H4CHR_03858	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4CHR_03861	COG5002	protein histidine kinase activity
H4CHR_03862	COG0745	RESPONSE REGULATOR receiver
H4CHR_03863	COG5002	protein histidine kinase activity
H4CHR_03863	COG2176	DNA-directed DNA polymerase activity
H4CHR_03866	COG1136	(ABC) transporter
H4CHR_03868	COG0058	SHG alpha-glucan phosphorylase activity
H4CHR_03869	COG0542	response to heat
H4CHR_03875	COG0640	Transcriptional regulator
H4CHR_03879	COG0459	protein refolding
H4CHR_03881	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4CHR_03882	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_03888	COG0589	response to stress
H4CHR_03889	COG0574	Belongs to the PEP-utilizing enzyme family
H4CHR_03889	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4CHR_03891	COG0071	Belongs to the small heat shock protein (HSP20) family
H4CHR_03894	COG0589	response to stress
H4CHR_03897	COG0589	response to stress
H4CHR_03898	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_03909	COG0589	response to stress
H4CHR_03911	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4CHR_03912	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4CHR_03917	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4CHR_03919	COG4670	ketone body catabolic process
H4CHR_03920	COG1053	succinate dehydrogenase
H4CHR_03921	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03925	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03927	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03929	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03930	COG3618	amidohydrolase
H4CHR_03932	COG0411	ABC transporter
H4CHR_03933	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_03934	COG2186	Transcriptional regulator
H4CHR_03935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_03938	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_03948	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_03949	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H4CHR_03951	COG0583	DNA-binding transcription factor activity
H4CHR_03953	COG1053	succinate dehydrogenase
H4CHR_03954	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4CHR_03955	COG0066	3-isopropylmalate dehydratase activity
H4CHR_03961	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4CHR_03964	COG0411	ABC transporter
H4CHR_03968	COG2982	Protein involved in outer membrane biogenesis
H4CHR_03973	COG1024	Enoyl-CoA hydratase
H4CHR_03976	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_03980	COG0589	response to stress
H4CHR_03983	COG1846	Transcriptional regulator
H4CHR_03983	COG0456	acetyltransferase
H4CHR_03984	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_03988	COG1295	ribonuclease BN
H4CHR_03991	COG0667	Aldo Keto reductase
H4CHR_03996	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4CHR_03997	COG1136	(ABC) transporter
H4CHR_04000	COG0626	cystathionine gamma-synthase activity
H4CHR_04003	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4CHR_04004	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H4CHR_04006	COG0330	HflC and HflK could
H4CHR_04007	COG0330	HflC and HflK could
H4CHR_04008	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4CHR_04009	COG1923	regulation of RNA biosynthetic process
H4CHR_04010	COG1160	GTP binding
H4CHR_04011	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4CHR_04013	COG0124	histidyl-tRNA synthetase
H4CHR_04014	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H4CHR_04017	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H4CHR_04018	COG0105	UTP biosynthetic process
H4CHR_04019	COG1187	pseudouridine synthase activity
H4CHR_04020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4CHR_04021	COG0564	pseudouridine synthase activity
H4CHR_04023	COG1199	ATP-dependent helicase activity
H4CHR_04027	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4CHR_04028	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4CHR_04029	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4CHR_04030	COG0567	Dehydrogenase, E1 component
H4CHR_04034	COG0583	DNA-binding transcription factor activity
H4CHR_04035	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_04037	COG3604	Transcriptional regulator
H4CHR_04038	COG1017	nitric oxide dioxygenase activity
H4CHR_04038	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4CHR_04041	COG1360	Flagellar Motor Protein
H4CHR_04045	COG0473	3-isopropylmalate dehydrogenase activity
H4CHR_04046	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4CHR_04048	COG2133	pyrroloquinoline quinone binding
H4CHR_04049	COG0791	NLP P60 protein
H4CHR_04053	COG1129	ABC transporter
H4CHR_04056	COG0154	amidase activity
H4CHR_04057	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4CHR_04062	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4CHR_04063	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4CHR_04064	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H4CHR_04066	COG4566	intracellular signal transduction
H4CHR_04067	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4CHR_04070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H4CHR_04071	COG0167	dihydroorotate dehydrogenase activity
H4CHR_04074	COG0579	oxidoreductase
H4CHR_04079	COG0443	Heat shock 70 kDa protein
H4CHR_04082	COG0822	iron-sulfur transferase activity
H4CHR_04083	COG1104	cysteine desulfurase activity
H4CHR_04084	COG1959	2 iron, 2 sulfur cluster binding
H4CHR_04085	COG0556	nucleotide-excision repair
H4CHR_04088	COG2878	Part of a membrane complex involved in electron transport
H4CHR_04091	COG4770	biotin carboxylase activity
H4CHR_04092	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4CHR_04093	COG1703	isobutyryl-CoA mutase activity
H4CHR_04094	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4CHR_04094	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4CHR_04095	COG1802	Transcriptional regulator
H4CHR_04099	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4CHR_04100	COG1201	RNA secondary structure unwinding
H4CHR_04101	COG2205	protein histidine kinase activity
H4CHR_04101	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4CHR_04107	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4CHR_04107	COG4651	solute:proton antiporter activity
H4CHR_04108	COG1301	dicarboxylic acid transport
H4CHR_04109	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_04111	COG0183	Belongs to the thiolase family
H4CHR_04112	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4CHR_04118	COG3045	CreA protein
H4CHR_04120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_04123	COG0583	DNA-binding transcription factor activity
H4CHR_04124	COG3622	Belongs to the hyi family
H4CHR_04126	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_04129	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_04131	COG2030	dehydratase
H4CHR_04133	COG1024	Enoyl-CoA hydratase
H4CHR_04134	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_04135	COG1960	acyl-CoA dehydrogenase activity
H4CHR_04137	COG1024	Enoyl-CoA hydratase
H4CHR_04141	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_04144	COG2909	trisaccharide binding
H4CHR_04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4CHR_04147	COG0583	DNA-binding transcription factor activity
H4CHR_04148	COG0625	glutathione transferase activity
H4CHR_04157	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_04158	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4CHR_04159	COG0066	3-isopropylmalate dehydratase activity
H4CHR_04161	COG0412	Dienelactone hydrolase
H4CHR_04169	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4CHR_04176	COG0270	DNA (cytosine-5-)-methyltransferase activity
H4CHR_04178	COG2948	multi-organism process
H4CHR_04184	COG3451	type IV secretory pathway VirB4
H4CHR_04187	COG4962	Type ii secretion system protein e
H4CHR_04190	COG0583	DNA-binding transcription factor activity
H4CHR_04194	COG0601	transmembrane transport
H4CHR_04196	COG4172	Belongs to the ABC transporter superfamily
H4CHR_04198	COG0242	peptide deformylase activity
H4CHR_04201	COG4638	Rieske (2fe-2S)
H4CHR_04203	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_04204	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4CHR_04206	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4CHR_04210	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_04216	COG0583	DNA-binding transcription factor activity
H4CHR_04218	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_04222	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4CHR_04223	COG1396	sequence-specific DNA binding
H4CHR_04225	COG4638	Rieske (2fe-2S)
H4CHR_04231	COG0596	Alpha beta hydrolase
H4CHR_04232	COG2309	aminopeptidase activity
H4CHR_04233	COG1335	isochorismatase
H4CHR_04243	COG1192	Involved in chromosome partitioning
H4CHR_04252	COG5489	Protein of unknown function (DUF736)
H4CHR_04253	COG1475	DNA binding
H4CHR_04256	COG2003	Belongs to the UPF0758 family
H4CHR_04260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4CHR_04261	COG1609	Transcriptional regulator
H4CHR_04262	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4CHR_04264	COG1116	anion transmembrane transporter activity
H4CHR_04266	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_04267	COG1024	Enoyl-CoA hydratase
H4CHR_04272	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_04276	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_04278	COG1024	Enoyl-CoA hydratase
H4CHR_04281	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_04284	COG0583	DNA-binding transcription factor activity
H4CHR_04285	COG0582	viral genome integration into host DNA
H4CHR_04288	COG0776	regulation of translation
H4CHR_04290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4CHR_04291	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4CHR_04292	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H4CHR_04293	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4CHR_04294	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4CHR_04295	COG2224	Isocitrate lyase
H4CHR_04300	COG1309	transcriptional regulator
H4CHR_04302	COG0673	inositol 2-dehydrogenase activity
H4CHR_04313	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4CHR_04317	COG0659	secondary active sulfate transmembrane transporter activity
H4CHR_04321	COG0542	response to heat
H4CHR_04325	COG0583	DNA-binding transcription factor activity
H4CHR_04326	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_04327	COG0314	molybdopterin synthase activity
H4CHR_04328	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4CHR_04329	COG0303	'Molybdopterin
H4CHR_04330	COG1763	Mo-molybdopterin cofactor biosynthetic process
H4CHR_04331	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4CHR_04333	COG0436	Aminotransferase
H4CHR_04335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4CHR_04336	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4CHR_04339	COG0305	Participates in initiation and elongation during chromosome replication
H4CHR_04340	COG0359	binds to the 23S rRNA
H4CHR_04341	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4CHR_04342	COG0360	Binds together with S18 to 16S ribosomal RNA
H4CHR_04345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H4CHR_04348	COG3634	alkyl hydroperoxide reductase activity
H4CHR_04355	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H4CHR_04356	COG0670	Belongs to the BI1 family
H4CHR_04357	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H4CHR_04360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4CHR_04361	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H4CHR_04362	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_04362	COG3321	synthase
H4CHR_04362	COG0604	alcohol dehydrogenase
H4CHR_04372	COG2226	methyltransferase
H4CHR_04415	COG0270	DNA (cytosine-5-)-methyltransferase activity
H4CHR_04433	COG0484	heat shock protein binding
H4CHR_04443	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4CHR_04446	COG0473	3-isopropylmalate dehydrogenase activity
H4CHR_04448	COG4968	Prepilin-type N-terminal cleavage methylation domain
H4CHR_04458	COG0322	excinuclease ABC activity
H4CHR_04460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4CHR_04461	COG1611	Belongs to the LOG family
H4CHR_04464	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4CHR_04466	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H4CHR_04467	COG3237	CsbD-like
H4CHR_04469	COG0824	Thioesterase
H4CHR_04470	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4CHR_04473	COG1959	2 iron, 2 sulfur cluster binding
H4CHR_04473	COG1295	ribonuclease BN
H4CHR_04474	COG0358	DNA primase activity
H4CHR_04476	COG2814	Major facilitator Superfamily
H4CHR_04479	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_04480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4CHR_04490	COG1802	Transcriptional regulator
H4CHR_04492	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H4CHR_04494	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_04498	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_04499	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4CHR_04501	COG2186	Transcriptional regulator
H4CHR_04502	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4CHR_04503	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4CHR_04506	COG2706	6-phosphogluconolactonase activity
H4CHR_04507	COG2721	sulfolactate sulfo-lyase activity
H4CHR_04509	COG2706	6-phosphogluconolactonase activity
H4CHR_04510	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_04511	COG0688	phosphatidylethanolamine metabolic process
H4CHR_04514	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4CHR_04515	COG0443	Heat shock 70 kDa protein
H4CHR_04516	COG0484	heat shock protein binding
H4CHR_04517	COG2186	Transcriptional regulator
H4CHR_04518	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_04520	COG2766	serine protein kinase
H4CHR_04521	COG2718	Belongs to the UPF0229 family
H4CHR_04522	COG2719	SpoVR family
H4CHR_04523	COG2818	Glycosylase
H4CHR_04524	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4CHR_04525	COG2186	Transcriptional regulator
H4CHR_04529	COG0625	glutathione transferase activity
H4CHR_04532	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H4CHR_04533	COG3265	gluconokinase activity
H4CHR_04536	COG1538	Outer membrane efflux protein
H4CHR_04539	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4CHR_04541	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_04542	COG0517	IMP dehydrogenase activity
H4CHR_04544	COG2267	carboxylic ester hydrolase activity
H4CHR_04545	COG0702	epimerase
H4CHR_04546	COG3118	belongs to the thioredoxin family
H4CHR_04547	COG1295	ribonuclease BN
H4CHR_04549	COG0277	FAD linked oxidase domain protein
H4CHR_04550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H4CHR_04559	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_04560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_04562	COG1129	ABC transporter
H4CHR_04564	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4CHR_04565	COG1879	ABC-type sugar transport system periplasmic component
H4CHR_04566	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4CHR_04568	COG1024	Enoyl-CoA hydratase
H4CHR_04569	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_04570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4CHR_04576	COG0708	Exodeoxyribonuclease III
H4CHR_04579	COG3852	Histidine kinase
H4CHR_04581	COG0174	glutamine synthetase
H4CHR_04582	COG1058	Belongs to the CinA family
H4CHR_04582	COG1546	Belongs to the CinA family
H4CHR_04587	COG1187	pseudouridine synthase activity
H4CHR_04589	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4CHR_04589	COG4797	methyltransferase
H4CHR_04592	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4CHR_04594	COG1063	alcohol dehydrogenase
H4CHR_04597	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_04602	COG0583	DNA-binding transcription factor activity
H4CHR_04603	COG3971	2-oxopent-4-enoate hydratase activity
H4CHR_04605	COG0277	FAD linked oxidase domain protein
H4CHR_04606	COG1012	belongs to the aldehyde dehydrogenase family
H4CHR_04608	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_04609	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4CHR_04613	COG0583	DNA-binding transcription factor activity
H4CHR_04617	COG3119	arylsulfatase activity
H4CHR_04620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4CHR_04624	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4CHR_04626	COG0287	Prephenate dehydrogenase
H4CHR_04627	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4CHR_04631	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H4CHR_04636	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4CHR_04637	COG2111	Na H antiporter
H4CHR_04637	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4CHR_04638	COG1006	Multisubunit Na H antiporter MnhC subunit
H4CHR_04639	COG0651	ATP synthesis coupled electron transport
H4CHR_04641	COG2212	antiporter activity
H4CHR_04642	COG1320	monovalent cation:proton antiporter activity
H4CHR_04649	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4CHR_04649	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4CHR_04657	COG1063	alcohol dehydrogenase
H4CHR_04662	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H4CHR_04662	COG3608	succinylglutamate desuccinylase aspartoacylase
H4CHR_04665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4CHR_04672	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4CHR_04673	COG3585	molybdate ion transport
H4CHR_04673	COG2005	Transcriptional regulator
H4CHR_04676	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4CHR_04679	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4CHR_04680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4CHR_04681	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4CHR_04682	COG1522	sequence-specific DNA binding
H4CHR_04684	COG1122	ATPase activity
H4CHR_04694	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4CHR_04695	COG2151	metal-sulfur cluster biosynthetic enzyme
H4CHR_04696	COG3396	Phenylacetate-CoA oxygenase
H4CHR_04697	COG3460	Phenylacetate-CoA oxygenase
H4CHR_04698	COG3396	Phenylacetate-CoA oxygenase
H4CHR_04700	COG2050	protein possibly involved in aromatic compounds catabolism
H4CHR_04701	COG1024	Enoyl-CoA hydratase
H4CHR_04703	COG1309	transcriptional regulator
H4CHR_04704	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4CHR_04708	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4CHR_04709	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4CHR_04710	COG0142	geranyltranstransferase activity
H4CHR_04711	COG1722	exodeoxyribonuclease VII activity
H4CHR_04719	COG3360	Dodecin
H4CHR_04722	COG0412	Dienelactone hydrolase
H4CHR_04724	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4CHR_04730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4CHR_04732	COG0210	DNA helicase
H4CHR_04734	COG0516	GMP reductase activity
H4CHR_04736	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_04737	COG0183	Belongs to the thiolase family
H4CHR_04740	COG0513	Belongs to the DEAD box helicase family
H4CHR_04741	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H4CHR_04742	COG0501	Belongs to the peptidase M48B family
H4CHR_04743	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4CHR_04744	COG1162	GTPase activity
H4CHR_04745	COG0297	glycogen (starch) synthase activity
H4CHR_04746	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4CHR_04747	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4CHR_04748	COG0494	nUDIX hydrolase
H4CHR_04749	COG0335	large ribosomal subunit rRNA binding
H4CHR_04750	COG0336	Belongs to the RNA methyltransferase TrmD family
H4CHR_04751	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4CHR_04752	COG0228	four-way junction DNA binding
H4CHR_04755	COG0306	phosphate transporter
H4CHR_04756	COG1392	Phosphate transport regulator
H4CHR_04757	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4CHR_04758	COG0617	tRNA 3'-terminal CCA addition
H4CHR_04759	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4CHR_04760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4CHR_04762	COG0438	transferase activity, transferring glycosyl groups
H4CHR_04766	COG0728	peptidoglycan biosynthetic process
H4CHR_04767	COG0268	Binds directly to 16S ribosomal RNA
H4CHR_04769	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4CHR_04770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4CHR_04771	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4CHR_04771	COG0506	proline dehydrogenase activity
H4CHR_04771	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4CHR_04772	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H4CHR_04774	COG3483	tryptophan 2,3-dioxygenase activity
H4CHR_04776	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_04780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4CHR_04785	COG2301	Belongs to the HpcH HpaI aldolase family
H4CHR_04786	COG4106	trans-aconitate 2-methyltransferase activity
H4CHR_04787	COG0039	L-malate dehydrogenase activity
H4CHR_04788	COG2188	Transcriptional regulator
H4CHR_04791	COG1053	succinate dehydrogenase
H4CHR_04792	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4CHR_04793	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H4CHR_04794	COG0372	Belongs to the citrate synthase family
H4CHR_04797	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4CHR_04798	COG0066	3-isopropylmalate dehydratase activity
H4CHR_04799	COG0473	3-isopropylmalate dehydrogenase activity
H4CHR_04800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4CHR_04802	COG0101	tRNA pseudouridine synthase activity
H4CHR_04803	COG0135	phosphoribosylanthranilate isomerase activity
H4CHR_04804	COG0133	tryptophan synthase activity
H4CHR_04805	COG0159	tryptophan synthase activity
H4CHR_04806	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4CHR_04807	COG0762	integral membrane protein
H4CHR_04809	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H4CHR_04810	COG0443	Heat shock 70 kDa protein
H4CHR_04811	COG1451	nucleotide metabolic process
H4CHR_04812	COG1472	Belongs to the glycosyl hydrolase 3 family
H4CHR_04813	COG0736	holo-[acyl-carrier-protein] synthase activity
H4CHR_04814	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H4CHR_04815	COG1381	Involved in DNA repair and RecF pathway recombination
H4CHR_04816	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4CHR_04817	COG0571	ribonuclease III activity
H4CHR_04820	COG0481	GTPase activity
H4CHR_04821	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_04825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4CHR_04826	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4CHR_04827	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_04828	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4CHR_04829	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4CHR_04830	COG0416	fatty acid biosynthetic process
H4CHR_04831	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4CHR_04832	COG1399	metal-binding, possibly nucleic acid-binding protein
H4CHR_04833	COG0424	maF-like protein
H4CHR_04834	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H4CHR_04835	COG2223	nitrite transmembrane transporter activity
H4CHR_04836	COG0616	signal peptide processing
H4CHR_04836	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4CHR_04839	COG0564	pseudouridine synthase activity
H4CHR_04840	COG1530	ribonuclease E activity
H4CHR_04843	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4CHR_04847	COG0297	glycogen (starch) synthase activity
H4CHR_04848	COG0489	protein tyrosine kinase activity
H4CHR_04848	COG3206	protein involved in exopolysaccharide biosynthesis
H4CHR_04849	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4CHR_04850	COG1596	polysaccharide export
H4CHR_04854	COG0181	hydroxymethylbilane synthase activity
H4CHR_04855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H4CHR_04856	COG0583	DNA-binding transcription factor activity
H4CHR_04857	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4CHR_04861	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_04862	COG0410	ABC transporter
H4CHR_04863	COG0411	ABC transporter
H4CHR_04865	COG1335	isochorismatase
H4CHR_04868	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4CHR_04872	COG1335	isochorismatase
H4CHR_04873	COG1942	4-Oxalocrotonate Tautomerase
H4CHR_04878	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H4CHR_04879	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_04881	COG1802	Transcriptional regulator
H4CHR_04883	COG0523	cobalamin synthesis protein
H4CHR_04885	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_04887	COG4948	Mandelate Racemase Muconate Lactonizing
H4CHR_04895	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4CHR_04895	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4CHR_04898	COG3022	response to hydroperoxide
H4CHR_04899	COG0525	valine-tRNA ligase activity
H4CHR_04900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4CHR_04902	COG0425	Belongs to the sulfur carrier protein TusA family
H4CHR_04903	COG2816	NAD+ diphosphatase activity
H4CHR_04906	COG0724	RNA recognition motif
H4CHR_04909	COG1301	dicarboxylic acid transport
H4CHR_04912	COG2197	response regulator
H4CHR_04913	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_04921	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_04922	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4CHR_04923	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H4CHR_04924	COG1674	ftsk spoiiie
H4CHR_04926	COG0492	ferredoxin-NADP+ reductase activity
H4CHR_04927	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4CHR_04928	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H4CHR_04930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4CHR_04930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4CHR_04931	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4CHR_04932	COG1960	acyl-CoA dehydrogenase activity
H4CHR_04933	COG1960	acyl-CoA dehydrogenase activity
H4CHR_04935	COG1024	Enoyl-CoA hydratase
H4CHR_04937	COG0196	riboflavin kinase activity
H4CHR_04939	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4CHR_04940	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4CHR_04943	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_04944	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_04945	COG4608	Belongs to the ABC transporter superfamily
H4CHR_04946	COG0444	Belongs to the ABC transporter superfamily
H4CHR_04948	COG0402	S-adenosylhomocysteine deaminase activity
H4CHR_04949	COG0747	negative chemotaxis
H4CHR_04951	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_04957	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4CHR_04958	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4CHR_04961	COG0084	hydrolase, TatD family'
H4CHR_04962	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_04963	COG0714	Associated with various cellular activities
H4CHR_04965	COG2304	oxidoreductase activity
H4CHR_04966	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_04967	COG0583	DNA-binding transcription factor activity
H4CHR_04969	COG0445	tRNA wobble uridine modification
H4CHR_04971	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4CHR_04972	COG1737	Transcriptional regulator
H4CHR_04977	COG0601	transmembrane transport
H4CHR_04979	COG0251	oxidation-reduction process
H4CHR_04983	COG3550	peptidyl-serine autophosphorylation
H4CHR_04985	COG1136	(ABC) transporter
H4CHR_04988	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4CHR_04994	COG0831	urea catabolic process
H4CHR_04996	COG0832	Belongs to the urease beta subunit family
H4CHR_04997	COG0804	urea catabolic process
H4CHR_05000	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H4CHR_05001	COG0830	nickel cation binding
H4CHR_05002	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H4CHR_05004	COG2175	clavaminate synthase activity
H4CHR_05005	COG3246	L-lysine catabolic process to acetate
H4CHR_05011	COG0028	Belongs to the TPP enzyme family
H4CHR_05019	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4CHR_05022	COG0235	Class ii aldolase
H4CHR_05024	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_05026	COG1024	Enoyl-CoA hydratase
H4CHR_05028	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4CHR_05033	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4CHR_05034	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4CHR_05040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4CHR_05041	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H4CHR_05042	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4CHR_05044	COG2815	serine threonine protein kinase
H4CHR_05044	COG0515	serine threonine protein kinase
H4CHR_05045	COG1561	YicC-like family, N-terminal region
H4CHR_05046	COG0194	GDP metabolic process
H4CHR_05047	COG1758	RNA polymerase activity
H4CHR_05048	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4CHR_05051	COG3971	2-oxopent-4-enoate hydratase activity
H4CHR_05052	COG4569	acetaldehyde dehydrogenase (acetylating) activity
H4CHR_05053	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4CHR_05057	COG2936	dipeptidyl-peptidase activity
H4CHR_05058	COG3246	L-lysine catabolic process to acetate
H4CHR_05059	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05062	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_05072	COG2084	Dehydrogenase
H4CHR_05074	COG1420	regulation of RNA biosynthetic process
H4CHR_05075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4CHR_05076	COG0497	DNA recombination
H4CHR_05077	COG1660	Displays ATPase and GTPase activities
H4CHR_05079	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H4CHR_05080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4CHR_05083	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H4CHR_05085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4CHR_05086	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H4CHR_05087	COG0193	aminoacyl-tRNA hydrolase activity
H4CHR_05089	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4CHR_05091	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4CHR_05093	COG4608	Belongs to the ABC transporter superfamily
H4CHR_05094	COG0747	negative chemotaxis
H4CHR_05095	COG0154	amidase activity
H4CHR_05096	COG0583	DNA-binding transcription factor activity
H4CHR_05102	COG0588	phosphoglycerate mutase activity
H4CHR_05103	COG2267	carboxylic ester hydrolase activity
H4CHR_05104	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H4CHR_05105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H4CHR_05106	COG1984	allophanate hydrolase subunit 2
H4CHR_05107	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4CHR_05108	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4CHR_05109	COG0742	ribosomal rna small subunit methyltransferase
H4CHR_05110	COG0612	Peptidase, M16
H4CHR_05111	COG0612	Peptidase, M16
H4CHR_05114	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4CHR_05115	COG1999	signal sequence binding
H4CHR_05116	COG0109	protoheme IX farnesyltransferase activity
H4CHR_05123	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H4CHR_05125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4CHR_05126	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4CHR_05128	COG2226	methyltransferase
H4CHR_05130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4CHR_05136	COG1024	Enoyl-CoA hydratase
H4CHR_05141	COG1960	acyl-CoA dehydrogenase activity
H4CHR_05145	COG2423	ornithine cyclodeaminase activity
H4CHR_05146	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_05152	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4CHR_05154	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4CHR_05155	COG2146	nitrite reductase [NAD(P)H] activity
H4CHR_05158	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4CHR_05160	COG1741	Belongs to the pirin family
H4CHR_05162	COG3473	Maleate cis-trans isomerase
H4CHR_05163	COG0596	Alpha beta hydrolase
H4CHR_05164	COG2309	aminopeptidase activity
H4CHR_05165	COG1335	isochorismatase
H4CHR_05166	COG0183	Belongs to the thiolase family
H4CHR_05167	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4CHR_05169	COG1414	Transcriptional regulator
H4CHR_05170	COG0776	regulation of translation
H4CHR_05171	COG4948	Mandelate Racemase Muconate Lactonizing
H4CHR_05182	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_05184	COG2814	Major facilitator Superfamily
H4CHR_05186	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05187	COG2814	Major facilitator Superfamily
H4CHR_05190	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4CHR_05195	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_05199	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4CHR_05201	COG2124	cytochrome p450
H4CHR_05205	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05206	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05216	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05224	COG2124	cytochrome p450
H4CHR_05226	COG1446	asparaginase
H4CHR_05227	COG4172	Belongs to the ABC transporter superfamily
H4CHR_05228	COG0747	negative chemotaxis
H4CHR_05230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4CHR_05236	COG1450	Type ii and iii secretion system protein
H4CHR_05241	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4CHR_05251	COG0583	DNA-binding transcription factor activity
H4CHR_05252	COG3485	protocatechuate 3,4-dioxygenase
H4CHR_05253	COG3485	protocatechuate 3,4-dioxygenase
H4CHR_05255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4CHR_05262	COG1056	cytidyltransferase-related domain
H4CHR_05262	COG1051	belongs to the nudix hydrolase family
H4CHR_05267	COG0540	Belongs to the ATCase OTCase family
H4CHR_05268	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H4CHR_05269	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4CHR_05270	COG1678	Uncharacterized ACR, COG1678
H4CHR_05271	COG0415	Belongs to the DNA photolyase family
H4CHR_05272	COG0643	Histidine kinase
H4CHR_05272	COG0784	Response regulator, receiver
H4CHR_05272	COG2198	Histidine kinase
H4CHR_05273	COG0840	transmembrane signaling receptor activity
H4CHR_05278	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4CHR_05279	COG0138	bifunctional purine biosynthesis protein purh
H4CHR_05282	COG1238	metal cluster binding
H4CHR_05283	COG0012	GTP binding
H4CHR_05284	COG0633	Ferredoxin
H4CHR_05284	COG3217	Mosc domain protein beta barrel domain protein
H4CHR_05285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_05288	COG1024	Enoyl-CoA hydratase
H4CHR_05299	COG2255	four-way junction helicase activity
H4CHR_05300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4CHR_05301	COG2267	carboxylic ester hydrolase activity
H4CHR_05302	COG0671	phosphoesterase, PA-phosphatase related
H4CHR_05302	COG2453	phosphatase
H4CHR_05305	COG4589	Belongs to the CDS family
H4CHR_05306	COG0632	four-way junction helicase activity
H4CHR_05307	COG1702	phosphate starvation-inducible protein PhoH
H4CHR_05308	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4CHR_05309	COG1490	D-aminoacyl-tRNA deacylase activity
H4CHR_05310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4CHR_05313	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4CHR_05314	COG0739	heme binding
H4CHR_05315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H4CHR_05316	COG2814	Major facilitator Superfamily
H4CHR_05317	COG0316	Belongs to the HesB IscA family
H4CHR_05318	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4CHR_05319	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H4CHR_05320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4CHR_05321	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4CHR_05324	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4CHR_05325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4CHR_05329	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4CHR_05331	COG0477	Major facilitator Superfamily
H4CHR_05336	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4CHR_05338	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4CHR_05339	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4CHR_05341	COG0156	8-amino-7-oxononanoate synthase activity
H4CHR_05344	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H4CHR_05346	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4CHR_05347	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_05348	COG1960	acyl-CoA dehydrogenase activity
H4CHR_05351	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4CHR_05352	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4CHR_05356	COG3012	SEC-C Motif Domain Protein
H4CHR_05358	COG1960	acyl-CoA dehydrogenase activity
H4CHR_05361	COG0183	Belongs to the thiolase family
H4CHR_05362	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H4CHR_05363	COG0288	reversible hydration of carbon dioxide
H4CHR_05364	COG0789	Transcriptional regulator
H4CHR_05367	COG0564	pseudouridine synthase activity
H4CHR_05371	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4CHR_05372	COG0751	glycine-tRNA ligase activity
H4CHR_05373	COG0752	glycyl-tRNA synthetase alpha subunit
H4CHR_05374	COG0252	asparaginase activity
H4CHR_05376	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H4CHR_05382	COG3186	Phenylalanine-4-hydroxylase
H4CHR_05384	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_05391	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_05392	COG0436	Aminotransferase
H4CHR_05394	COG0697	spore germination
H4CHR_05395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4CHR_05397	COG1280	lysine exporter protein (LysE YggA)
H4CHR_05398	COG0625	glutathione transferase activity
H4CHR_05399	COG0384	phenazine biosynthesis protein PhzF
H4CHR_05404	COG3485	protocatechuate 3,4-dioxygenase
H4CHR_05405	COG3468	outer membrane autotransporter barrel domain protein
H4CHR_05407	COG1324	tolerance protein
H4CHR_05413	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4CHR_05415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4CHR_05416	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4CHR_05417	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4CHR_05420	COG0679	Auxin Efflux Carrier
H4CHR_05421	COG0210	DNA helicase
H4CHR_05430	COG2186	Transcriptional regulator
H4CHR_05440	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_05442	COG0583	DNA-binding transcription factor activity
H4CHR_05453	COG1960	acyl-CoA dehydrogenase activity
H4CHR_05454	COG1960	acyl-CoA dehydrogenase activity
H4CHR_05455	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_05456	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_05458	COG2030	dehydratase
H4CHR_05459	COG1024	Enoyl-CoA hydratase
H4CHR_05460	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05463	COG1024	Enoyl-CoA hydratase
H4CHR_05469	COG1802	Transcriptional regulator
H4CHR_05470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4CHR_05471	COG1116	anion transmembrane transporter activity
H4CHR_05472	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4CHR_05480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4CHR_05484	COG0765	amino acid transport
H4CHR_05487	COG3119	arylsulfatase activity
H4CHR_05493	COG2204	response regulator
H4CHR_05494	COG5000	phosphorelay sensor kinase activity
H4CHR_05496	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4CHR_05496	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4CHR_05498	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4CHR_05499	COG0085	RNA polymerase activity
H4CHR_05500	COG0222	ribosome binding
H4CHR_05501	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4CHR_05503	COG0081	regulation of translation
H4CHR_05504	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4CHR_05506	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4CHR_05508	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4CHR_05512	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4CHR_05513	COG0134	indole-3-glycerol-phosphate synthase activity
H4CHR_05514	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4CHR_05520	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05522	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_05528	COG4638	Rieske (2fe-2S)
H4CHR_05531	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05532	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H4CHR_05543	COG0604	alcohol dehydrogenase
H4CHR_05543	COG3321	synthase
H4CHR_05543	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05545	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4CHR_05547	COG0546	phosphoglycolate phosphatase activity
H4CHR_05548	COG2197	response regulator
H4CHR_05550	COG3916	Acyl-homoserine-lactone synthase
H4CHR_05552	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H4CHR_05552	COG2885	chlorophyll binding
H4CHR_05554	COG0745	RESPONSE REGULATOR receiver
H4CHR_05562	COG0631	protein serine/threonine phosphatase activity
H4CHR_05563	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4CHR_05567	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H4CHR_05568	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H4CHR_05571	COG4251	negative regulation of phosphorylation
H4CHR_05580	COG0018	arginyl-trna synthetase
H4CHR_05582	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4CHR_05583	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H4CHR_05584	COG1137	ATPase activity
H4CHR_05585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4CHR_05586	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4CHR_05588	COG2353	YceI-like domain
H4CHR_05589	COG3038	cytochrome b561
H4CHR_05592	COG4585	Histidine kinase
H4CHR_05597	COG0617	tRNA 3'-terminal CCA addition
H4CHR_05597	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H4CHR_05597	COG3620	sequence-specific DNA binding
H4CHR_05598	COG3179	chitinase
H4CHR_05601	COG0653	protein targeting
H4CHR_05606	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4CHR_05609	COG2197	response regulator
H4CHR_05610	COG2205	protein histidine kinase activity
H4CHR_05610	COG2198	Histidine kinase
H4CHR_05610	COG0784	Response regulator, receiver
H4CHR_05613	COG1396	sequence-specific DNA binding
H4CHR_05614	COG0235	Class ii aldolase
H4CHR_05615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4CHR_05620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4CHR_05622	COG2967	ApaG domain
H4CHR_05623	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4CHR_05629	COG2084	Dehydrogenase
H4CHR_05632	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_05633	COG1609	Transcriptional regulator
H4CHR_05641	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_05642	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4CHR_05646	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4CHR_05647	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4CHR_05655	COG0583	DNA-binding transcription factor activity
H4CHR_05659	COG0205	6-phosphofructokinase activity
H4CHR_05661	COG2814	Major facilitator Superfamily
H4CHR_05662	COG0121	glutamine amidotransferase
H4CHR_05666	COG0189	ligase activity
H4CHR_05667	COG3135	benzoate transporter
H4CHR_05668	COG3158	transport of potassium into the cell
H4CHR_05670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4CHR_05673	COG0495	leucyl-tRNA aminoacylation
H4CHR_05676	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4CHR_05677	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4CHR_05678	COG0735	belongs to the Fur family
H4CHR_05679	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H4CHR_05681	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4CHR_05682	COG0210	DNA helicase
H4CHR_05683	COG0598	Magnesium transport protein CorA
H4CHR_05684	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_05688	COG0745	RESPONSE REGULATOR receiver
H4CHR_05691	COG0482	sulfurtransferase activity
H4CHR_05693	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4CHR_05697	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4CHR_05699	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4CHR_05700	COG0438	transferase activity, transferring glycosyl groups
H4CHR_05701	COG0438	transferase activity, transferring glycosyl groups
H4CHR_05705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4CHR_05706	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4CHR_05708	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4CHR_05709	COG1596	polysaccharide export
H4CHR_05710	COG0629	single-stranded DNA binding
H4CHR_05714	COG1946	Acyl-CoA thioesterase
H4CHR_05717	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4CHR_05718	COG3181	Tripartite tricarboxylate transporter family receptor
H4CHR_05720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_05723	COG0583	DNA-binding transcription factor activity
H4CHR_05725	COG2205	protein histidine kinase activity
H4CHR_05725	COG3437	response regulator, receiver
H4CHR_05725	COG3850	Histidine kinase
H4CHR_05725	COG4999	Histidine kinase
H4CHR_05727	COG0745	RESPONSE REGULATOR receiver
H4CHR_05731	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_05732	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H4CHR_05741	COG0284	orotidine-5'-phosphate decarboxylase activity
H4CHR_05744	COG1214	PFAM Peptidase M22, glycoprotease
H4CHR_05747	COG0009	L-threonylcarbamoyladenylate synthase
H4CHR_05748	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4CHR_05749	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H4CHR_05750	COG3118	belongs to the thioredoxin family
H4CHR_05754	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H4CHR_05756	COG0469	pyruvate kinase activity
H4CHR_05757	COG0126	phosphoglycerate kinase activity
H4CHR_05758	COG0583	DNA-binding transcription factor activity
H4CHR_05761	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_05765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4CHR_05767	COG0242	peptide deformylase activity
H4CHR_05769	COG0758	DNA mediated transformation
H4CHR_05770	COG2922	Belongs to the Smg family
H4CHR_05772	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4CHR_05773	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4CHR_05774	COG1862	Preprotein translocase
H4CHR_05776	COG1522	sequence-specific DNA binding
H4CHR_05777	COG2814	Major facilitator Superfamily
H4CHR_05787	COG3622	Belongs to the hyi family
H4CHR_05788	COG0235	Class ii aldolase
H4CHR_05789	COG3395	kinase activity
H4CHR_05790	COG2084	Dehydrogenase
H4CHR_05793	COG0513	Belongs to the DEAD box helicase family
H4CHR_05794	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H4CHR_05795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4CHR_05797	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4CHR_05799	COG0551	DNA topoisomerase type I activity
H4CHR_05799	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4CHR_05801	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H4CHR_05801	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H4CHR_05810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4CHR_05811	COG2137	regulation of response to DNA damage stimulus
H4CHR_05812	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4CHR_05813	COG0045	succinate-CoA ligase (ADP-forming) activity
H4CHR_05814	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4CHR_05815	COG0861	Integral membrane protein TerC family
H4CHR_05816	COG0631	protein serine/threonine phosphatase activity
H4CHR_05820	COG4969	Belongs to the N-Me-Phe pilin family
H4CHR_05828	COG0315	cyclic pyranopterin monophosphate synthase activity
H4CHR_05829	COG4783	chaperone-mediated protein folding
H4CHR_05830	COG1950	PFAM Membrane protein of
H4CHR_05832	COG0861	Integral membrane protein TerC family
H4CHR_05839	COG4269	membrane
H4CHR_05840	COG0625	glutathione transferase activity
H4CHR_05843	COG1595	DNA-templated transcription, initiation
H4CHR_05844	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4CHR_05845	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H4CHR_05849	COG4566	intracellular signal transduction
H4CHR_05855	COG1522	sequence-specific DNA binding
H4CHR_05857	COG1309	transcriptional regulator
H4CHR_05858	COG0346	lactoylglutathione lyase activity
H4CHR_05867	COG1058	Belongs to the CinA family
H4CHR_05867	COG1546	Belongs to the CinA family
H4CHR_05868	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05871	COG4221	oxidoreductase activity
H4CHR_05872	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05873	COG1047	Peptidyl-prolyl cis-trans
H4CHR_05880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4CHR_05882	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_05883	COG0667	Aldo Keto reductase
H4CHR_05887	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4CHR_05890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4CHR_05892	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H4CHR_05896	COG1959	2 iron, 2 sulfur cluster binding
H4CHR_05896	COG1295	ribonuclease BN
H4CHR_05898	COG0445	tRNA wobble uridine modification
H4CHR_05911	COG0583	DNA-binding transcription factor activity
H4CHR_05912	COG1335	isochorismatase
H4CHR_05913	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H4CHR_05919	COG0583	DNA-binding transcription factor activity
H4CHR_05921	COG1620	l-lactate permease
H4CHR_05922	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4CHR_05923	COG1028	Short-chain dehydrogenase reductase Sdr
H4CHR_05928	COG4548	von Willebrand factor, type A
H4CHR_05930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4CHR_05936	COG1309	transcriptional regulator
H4CHR_05940	COG0604	alcohol dehydrogenase
H4CHR_05942	COG0583	DNA-binding transcription factor activity
H4CHR_05947	COG0583	DNA-binding transcription factor activity
H4CHR_05948	COG3485	protocatechuate 3,4-dioxygenase
H4CHR_05950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4CHR_05954	COG1137	ATPase activity
H4CHR_05956	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H4CHR_05959	COG3546	catalase activity
H4CHR_05960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4CHR_05962	COG2204	response regulator
H4CHR_05973	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4CHR_05987	COG0514	ATP-dependent DNA helicase (RecQ)
H4CHR_06004	COG1809	phosphosulfolactate synthase activity
H4CHR_06006	COG1448	Aminotransferase
H4CHR_06007	COG3119	arylsulfatase activity
H4CHR_06008	COG0583	DNA-binding transcription factor activity
H4CHR_06010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4CHR_06013	COG3971	2-oxopent-4-enoate hydratase activity
H4CHR_06014	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4CHR_06018	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4CHR_06025	COG3237	CsbD-like
H4CHR_06027	COG1960	acyl-CoA dehydrogenase activity
H4CHR_06028	COG0318	PFAM AMP-dependent synthetase and ligase
H4CHR_06033	COG1846	Transcriptional regulator
H4CHR_06034	COG0277	FAD linked oxidase domain protein
H4CHR_06034	COG0247	lactate metabolic process
H4CHR_06035	COG1802	Transcriptional regulator
H4CHR_06036	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H4CHR_06040	COG2094	Belongs to the DNA glycosylase MPG family
H4CHR_06047	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H4CHR_06051	COG2188	Transcriptional regulator
H4CHR_06052	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4CHR_06053	COG0066	3-isopropylmalate dehydratase activity
H4CHR_06056	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4CHR_06057	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4CHR_06058	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4CHR_06064	COG0006	proline dipeptidase activity
H4CHR_06068	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4CHR_06072	COG0281	malic enzyme
H4CHR_06072	COG0280	phosphate acetyltransferase
H4CHR_06076	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4CHR_06077	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4CHR_06078	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H4CHR_06080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4CHR_06083	COG2814	Major facilitator Superfamily
H4CHR_06087	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4CHR_06088	COG2813	Specifically methylates the guanine in position
H4CHR_06088	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4CHR_06089	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4CHR_06090	COG2119	membrane
H4CHR_06091	COG0724	RNA recognition motif
H4CHR_06092	COG0300	oxidoreductase activity
H4CHR_06094	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4CHR_06099	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4CHR_06100	COG0706	membrane insertase activity
H4CHR_06101	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H4CHR_06102	COG0594	ribonuclease P activity
H4CHR_06103	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H4P1_00001	COG1192	Involved in chromosome partitioning
H4P1_00004	COG0358	DNA primase activity
H4P1_00018	COG0384	phenazine biosynthesis protein PhzF
H4P1_00041	COG3285	dna ligase
H4P1_00041	COG1793	dna ligase
H4P1_00043	COG2815	serine threonine protein kinase
H4P1_00043	COG0515	serine threonine protein kinase
H4P1_00058	COG2826	transposase and inactivated derivatives, IS30 family
H4P1_00076	COG2801	Transposase and inactivated derivatives
H4P1_00076	COG3415	Transposase
H4P1_00087	COG2936	dipeptidyl-peptidase activity
H4P2_00001	COG1192	Involved in chromosome partitioning
H4P2_00004	COG1484	DNA-dependent DNA replication
H4P2_00005	COG4584	PFAM Integrase catalytic
H4P2_00029	COG4372	Transposase
H4P2_00046	COG2003	Belongs to the UPF0758 family
H4P2_00064	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4P2_00073	COG2948	multi-organism process
H4P2_00085	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H4P2_00096	COG3041	Addiction module toxin RelE StbE family
H4P2_00097	COG3077	Addiction module antitoxin, RelB DinJ family
H4P2_00110	COG1569	PIN domain
H4P2_00111	COG3311	Transcriptional regulator