locus-tag	class	description
C4F17_00010	COG2766	serine protein kinase
C4F17_00020	COG0443	Heat shock 70 kDa protein
C4F17_00025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4F17_00040	COG0688	phosphatidylethanolamine metabolic process
C4F17_00055	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_00060	COG2721	sulfolactate sulfo-lyase activity
C4F17_00065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4F17_00075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_00085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4F17_00090	COG2186	Transcriptional regulator
C4F17_00095	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_00100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4F17_00110	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_00135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_00150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4F17_00160	COG1802	Transcriptional regulator
C4F17_00205	COG0583	DNA-binding transcription factor activity
C4F17_00210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4F17_00215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_00220	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_00230	COG2814	Major facilitator Superfamily
C4F17_00235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4F17_00245	COG1959	2 iron, 2 sulfur cluster binding
C4F17_00245	COG1295	ribonuclease BN
C4F17_00260	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4F17_00275	COG3237	CsbD-like
C4F17_00280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4F17_00290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4F17_00295	COG1322	Protein conserved in bacteria
C4F17_00305	COG1611	Belongs to the LOG family
C4F17_00310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4F17_00325	COG0405	Gamma-glutamyltransferase
C4F17_00330	COG0322	excinuclease ABC activity
C4F17_00345	COG0583	DNA-binding transcription factor activity
C4F17_00350	COG0596	Alpha beta hydrolase
C4F17_00355	COG0473	3-isopropylmalate dehydrogenase activity
C4F17_00410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4F17_00415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4F17_00430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4F17_00435	COG0670	Belongs to the BI1 family
C4F17_00440	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4F17_00470	COG3128	pkhd-type hydroxylase
C4F17_00475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4F17_00480	COG1477	protein flavinylation
C4F17_00510	COG3634	alkyl hydroperoxide reductase activity
C4F17_00515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4F17_00530	COG0360	Binds together with S18 to 16S ribosomal RNA
C4F17_00535	COG2965	DNA replication, synthesis of RNA primer
C4F17_00540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4F17_00545	COG0359	binds to the 23S rRNA
C4F17_00550	COG0305	Participates in initiation and elongation during chromosome replication
C4F17_00575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4F17_00580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4F17_00590	COG0436	Aminotransferase
C4F17_00605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4F17_00610	COG1763	Mo-molybdopterin cofactor biosynthetic process
C4F17_00615	COG0303	'Molybdopterin
C4F17_00625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4F17_00630	COG0314	molybdopterin synthase activity
C4F17_00640	COG0542	response to heat
C4F17_00650	COG0183	Belongs to the thiolase family
C4F17_00665	COG0583	DNA-binding transcription factor activity
C4F17_00690	COG1595	DNA-templated transcription, initiation
C4F17_00695	COG3712	iron ion homeostasis
C4F17_00710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4F17_00725	COG2814	Major facilitator Superfamily
C4F17_00745	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_00750	COG4974	Belongs to the 'phage' integrase family
C4F17_00765	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_00770	COG1309	transcriptional regulator
C4F17_00775	COG0183	Belongs to the thiolase family
C4F17_00785	COG2833	Protein of unknown function (DUF455)
C4F17_00795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4F17_00810	COG3201	nicotinamide mononucleotide transporter
C4F17_00815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C4F17_00820	COG0148	phosphopyruvate hydratase activity
C4F17_00830	COG0504	CTP synthase activity
C4F17_00835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4F17_00845	COG0756	dUTP diphosphatase activity
C4F17_00855	COG1047	Peptidyl-prolyl cis-trans
C4F17_00860	COG2850	peptidyl-arginine hydroxylation
C4F17_00880	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4F17_00885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4F17_00895	COG2814	Major facilitator Superfamily
C4F17_00900	COG0187	DNA topoisomerase II activity
C4F17_00910	COG0741	lytic transglycosylase activity
C4F17_00910	COG0739	heme binding
C4F17_00910	COG1196	nuclear chromosome segregation
C4F17_00940	COG0765	amino acid transport
C4F17_00945	COG0765	amino acid transport
C4F17_00955	COG1126	abc transporter atp-binding protein
C4F17_00965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4F17_00975	COG1609	Transcriptional regulator
C4F17_00985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_00995	COG0745	RESPONSE REGULATOR receiver
C4F17_01005	COG0784	Response regulator, receiver
C4F17_01005	COG2205	protein histidine kinase activity
C4F17_01015	COG3942	CHAP domain
C4F17_01015	COG1388	LysM domain
C4F17_01020	COG3501	Rhs element vgr protein
C4F17_01035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_01050	COG1024	Enoyl-CoA hydratase
C4F17_01060	COG0583	DNA-binding transcription factor activity
C4F17_01065	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_01070	COG3196	Protein conserved in bacteria
C4F17_01095	COG1305	Transglutaminase-like
C4F17_01120	COG1024	Enoyl-CoA hydratase
C4F17_01125	COG2308	Evidence 4 Homologs of previously reported genes of
C4F17_01135	COG3210	domain, Protein
C4F17_01135	COG3210	domain, Protein
C4F17_01150	COG2831	hemolysin activation secretion protein
C4F17_01155	COG2194	sulfuric ester hydrolase activity
C4F17_01165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4F17_01185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4F17_01200	COG1131	(ABC) transporter
C4F17_01210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4F17_01230	COG2951	lytic endotransglycosylase activity
C4F17_01245	COG0714	Associated with various cellular activities
C4F17_01255	COG3264	Mechanosensitive ion channel
C4F17_01255	COG1511	domain protein
C4F17_01260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4F17_01275	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_01295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4F17_01300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4F17_01310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_01320	COG0747	negative chemotaxis
C4F17_01340	COG1960	acyl-CoA dehydrogenase activity
C4F17_01355	COG4988	ABC transporter
C4F17_01360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C4F17_01365	COG1271	oxidase subunit
C4F17_01370	COG1294	oxidase, subunit
C4F17_01395	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_01405	COG2030	dehydratase
C4F17_01415	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_01420	COG1024	Enoyl-CoA hydratase
C4F17_01425	COG3128	pkhd-type hydroxylase
C4F17_01450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4F17_01460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4F17_01465	COG3501	Rhs element vgr protein
C4F17_01470	COG3209	COG3209 Rhs family protein
C4F17_01490	COG3209	COG3209 Rhs family protein
C4F17_01530	COG0745	RESPONSE REGULATOR receiver
C4F17_01545	COG1414	Transcriptional regulator
C4F17_01550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4F17_01555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4F17_01560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4F17_01570	COG2814	Major facilitator Superfamily
C4F17_01575	COG0596	Alpha beta hydrolase
C4F17_01585	COG0477	Major facilitator Superfamily
C4F17_01640	COG1609	Transcriptional regulator
C4F17_01640	COG2207	Transcriptional regulator
C4F17_01665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4F17_01685	COG1309	transcriptional regulator
C4F17_01700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4F17_01700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4F17_01705	COG0509	glycine decarboxylation via glycine cleavage system
C4F17_01710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4F17_01715	COG1902	pentaerythritol trinitrate reductase activity
C4F17_01735	COG2072	flavoprotein involved in K transport
C4F17_01740	COG2814	Major facilitator Superfamily
C4F17_01755	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_01785	COG2223	nitrite transmembrane transporter activity
C4F17_01805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_01810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4F17_01825	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_01840	COG0642	Histidine kinase
C4F17_01845	COG0745	RESPONSE REGULATOR receiver
C4F17_01855	COG0671	phosphoesterase, PA-phosphatase related
C4F17_01885	COG4302	ethanolamine ammonia-lyase activity
C4F17_01890	COG4303	Ethanolamine ammonia lyase large subunit
C4F17_01895	COG0531	amino acid
C4F17_01900	COG0545	Peptidyl-prolyl cis-trans isomerase
C4F17_01905	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_01910	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4F17_01920	COG3284	Transcriptional regulator
C4F17_01925	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_01940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_01945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4F17_01975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_01985	COG0436	Aminotransferase
C4F17_02010	COG1024	Enoyl-CoA hydratase
C4F17_02050	COG5383	Protein conserved in bacteria
C4F17_02055	COG0277	FAD linked oxidase domain protein
C4F17_02070	COG3384	dioxygenase
C4F17_02080	COG2159	amidohydrolase
C4F17_02085	COG0583	DNA-binding transcription factor activity
C4F17_02095	COG0840	transmembrane signaling receptor activity
C4F17_02105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4F17_02115	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4F17_02120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4F17_02140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4F17_02145	COG0366	Alpha amylase catalytic
C4F17_02150	COG0366	Alpha amylase catalytic
C4F17_02165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4F17_02170	COG1640	4-alpha-glucanotransferase
C4F17_02195	COG0840	transmembrane signaling receptor activity
C4F17_02220	COG3145	DNA-N1-methyladenine dioxygenase activity
C4F17_02230	COG0583	DNA-binding transcription factor activity
C4F17_02240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_02255	COG3045	CreA protein
C4F17_02290	COG3243	poly(R)-hydroxyalkanoic acid synthase
C4F17_02295	COG0183	Belongs to the thiolase family
C4F17_02305	COG0625	glutathione transferase activity
C4F17_02315	COG0583	DNA-binding transcription factor activity
C4F17_02325	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4F17_02345	COG1058	Belongs to the CinA family
C4F17_02345	COG1546	Belongs to the CinA family
C4F17_02355	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_02360	COG1301	dicarboxylic acid transport
C4F17_02365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4F17_02365	COG4651	solute:proton antiporter activity
C4F17_02380	COG4774	siderophore transport
C4F17_02435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4F17_02470	COG1793	dna ligase
C4F17_02530	COG0402	S-adenosylhomocysteine deaminase activity
C4F17_02545	COG1129	ABC transporter
C4F17_02560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4F17_02565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4F17_02570	COG1309	transcriptional regulator
C4F17_02600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_02615	COG0583	DNA-binding transcription factor activity
C4F17_02640	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4F17_02645	COG0583	DNA-binding transcription factor activity
C4F17_02675	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_02695	COG2885	chlorophyll binding
C4F17_02700	COG1522	sequence-specific DNA binding
C4F17_02705	COG0028	Belongs to the TPP enzyme family
C4F17_02725	COG0745	RESPONSE REGULATOR receiver
C4F17_02740	COG1802	Transcriptional regulator
C4F17_02755	COG1703	isobutyryl-CoA mutase activity
C4F17_02760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4F17_02765	COG0439	Biotin carboxylase
C4F17_02770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4F17_02780	COG1522	sequence-specific DNA binding
C4F17_02785	COG0697	spore germination
C4F17_02795	COG2878	Part of a membrane complex involved in electron transport
C4F17_02815	COG1959	2 iron, 2 sulfur cluster binding
C4F17_02820	COG1104	cysteine desulfurase activity
C4F17_02825	COG0822	iron-sulfur transferase activity
C4F17_02835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4F17_02840	COG0443	Heat shock 70 kDa protein
C4F17_02845	COG0633	Ferredoxin
C4F17_02865	COG0579	oxidoreductase
C4F17_02880	COG0167	dihydroorotate dehydrogenase activity
C4F17_02885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4F17_02900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4F17_02905	COG4566	intracellular signal transduction
C4F17_02915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4F17_02920	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4F17_02925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4F17_02930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4F17_02935	COG0791	NLP P60 protein
C4F17_02945	COG2368	4-hydroxyphenylacetate
C4F17_02965	COG0567	Dehydrogenase, E1 component
C4F17_02970	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4F17_02975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4F17_02980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4F17_03000	COG1199	ATP-dependent helicase activity
C4F17_03010	COG0564	pseudouridine synthase activity
C4F17_03015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4F17_03020	COG1187	pseudouridine synthase activity
C4F17_03025	COG0105	UTP biosynthetic process
C4F17_03030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4F17_03045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4F17_03050	COG0124	histidyl-tRNA synthetase
C4F17_03060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4F17_03065	COG1160	GTP binding
C4F17_03070	COG1923	regulation of RNA biosynthetic process
C4F17_03075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4F17_03080	COG0330	HflC and HflK could
C4F17_03085	COG0330	HflC and HflK could
C4F17_03095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4F17_03100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4F17_03120	COG0626	cystathionine gamma-synthase activity
C4F17_03135	COG4181	ATPase activity
C4F17_03150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4F17_03175	COG0667	Aldo Keto reductase
C4F17_03180	COG2059	Chromate
C4F17_03190	COG1295	ribonuclease BN
C4F17_03210	COG4689	acetoacetate decarboxylase
C4F17_03215	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_03220	COG1846	Transcriptional regulator
C4F17_03220	COG0456	acetyltransferase
C4F17_03230	COG3706	GGDEF domain
C4F17_03235	COG2202	Pas domain
C4F17_03235	COG2200	EAL domain
C4F17_03235	COG2199	diguanylate cyclase activity
C4F17_03250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_03255	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_03260	COG1522	sequence-specific DNA binding
C4F17_03280	COG1024	Enoyl-CoA hydratase
C4F17_03290	COG1960	acyl-CoA dehydrogenase activity
C4F17_03325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_03330	COG0235	Class ii aldolase
C4F17_03340	COG2186	Transcriptional regulator
C4F17_03345	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_03350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4F17_03355	COG2267	carboxylic ester hydrolase activity
C4F17_03380	COG0625	glutathione transferase activity
C4F17_03400	COG3634	alkyl hydroperoxide reductase activity
C4F17_03420	COG0248	Ppx GppA phosphatase
C4F17_03425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4F17_03430	COG0573	inorganic phosphate transmembrane transporter activity
C4F17_03435	COG0581	inorganic phosphate transmembrane transporter activity
C4F17_03440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4F17_03455	COG5002	protein histidine kinase activity
C4F17_03460	COG0534	Mate efflux family protein
C4F17_03470	COG0254	rRNA binding
C4F17_03475	COG0673	inositol 2-dehydrogenase activity
C4F17_03480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4F17_03495	COG1074	ATP-dependent DNA helicase activity
C4F17_03510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4F17_03515	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4F17_03520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4F17_03530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_03540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_03550	COG1388	LysM domain
C4F17_03550	COG0741	lytic transglycosylase activity
C4F17_03555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4F17_03565	COG0328	RNA-DNA hybrid ribonuclease activity
C4F17_03580	COG0746	molybdenum cofactor guanylyltransferase activity
C4F17_03585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4F17_03605	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_03615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_03675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_03705	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4F17_03735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4F17_03760	COG0028	Belongs to the TPP enzyme family
C4F17_03765	COG0440	acetolactate synthase activity
C4F17_03775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4F17_03780	COG1183	phosphatidylcholine synthase activity
C4F17_03785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4F17_03790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4F17_03800	COG1414	Transcriptional regulator
C4F17_03805	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4F17_03810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4F17_03835	COG1414	Transcriptional regulator
C4F17_03840	COG0745	RESPONSE REGULATOR receiver
C4F17_03845	COG0642	Histidine kinase
C4F17_03850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4F17_03880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4F17_03885	COG1742	UPF0060 membrane protein
C4F17_03915	COG2022	thiamine diphosphate biosynthetic process
C4F17_03930	COG0351	phosphomethylpyrimidine kinase
C4F17_03940	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4F17_03955	COG0492	ferredoxin-NADP+ reductase activity
C4F17_03960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4F17_03965	COG2895	sulfate adenylyltransferase (ATP) activity
C4F17_03975	COG0175	sulfate reduction
C4F17_04005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_04010	COG0601	transmembrane transport
C4F17_04020	COG4172	Belongs to the ABC transporter superfamily
C4F17_04025	COG1446	asparaginase
C4F17_04035	COG2755	lipolytic protein G-D-S-L family
C4F17_04035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4F17_04055	COG1803	Methylglyoxal synthase
C4F17_04060	COG0583	DNA-binding transcription factor activity
C4F17_04065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_04085	COG3588	fructose-bisphosphate aldolase
C4F17_04090	COG0427	acetyl-CoA hydrolase
C4F17_04115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4F17_04125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4F17_04130	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C4F17_04135	COG0745	RESPONSE REGULATOR receiver
C4F17_04140	COG5002	protein histidine kinase activity
C4F17_04150	COG0584	glycerophosphoryl diester phosphodiesterase
C4F17_04170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_04170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4F17_04180	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4F17_04190	COG0431	NADPH-dependent FMN reductase
C4F17_04195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_04200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_04205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_04210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_04215	COG1116	anion transmembrane transporter activity
C4F17_04225	COG0778	Nitroreductase
C4F17_04250	COG1045	serine acetyltransferase
C4F17_04260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4F17_04265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4F17_04280	COG3550	peptidyl-serine autophosphorylation
C4F17_04285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4F17_04295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4F17_04305	COG0450	alkyl hydroperoxide reductase
C4F17_04315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4F17_04325	COG4208	sulfate ABC transporter
C4F17_04330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4F17_04335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4F17_04340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_04350	COG1538	Outer membrane efflux protein
C4F17_04365	COG1196	nuclear chromosome segregation
C4F17_04375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4F17_04385	COG0242	peptide deformylase activity
C4F17_04390	COG2259	Doxx family
C4F17_04395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4F17_04400	COG4597	amino acid ABC transporter
C4F17_04405	COG0765	amino acid transport
C4F17_04415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4F17_04440	COG0457	Tetratricopeptide repeat
C4F17_04445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C4F17_04450	COG1215	transferase activity, transferring glycosyl groups
C4F17_04455	COG1215	transferase activity, transferring glycosyl groups
C4F17_04460	COG1192	Involved in chromosome partitioning
C4F17_04475	COG5001	Diguanylate cyclase
C4F17_04475	COG5002	protein histidine kinase activity
C4F17_04475	COG3447	MASE1 domain protein
C4F17_04480	COG2203	Gaf domain
C4F17_04480	COG2199	diguanylate cyclase activity
C4F17_04485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4F17_04490	COG0024	Methionine aminopeptidase
C4F17_04495	COG0047	phosphoribosylformylglycinamidine synthase activity
C4F17_04495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4F17_04500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4F17_04510	COG2917	probably involved in intracellular septation
C4F17_04515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4F17_04520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4F17_04530	COG2272	Belongs to the type-B carboxylesterase lipase family
C4F17_04535	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_04550	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_04560	COG0411	ABC transporter
C4F17_04575	COG1024	Enoyl-CoA hydratase
C4F17_04575	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_04585	COG0183	Belongs to the thiolase family
C4F17_04590	COG1960	acyl-CoA dehydrogenase activity
C4F17_04615	COG2130	NADP-dependent
C4F17_04620	COG1960	acyl-CoA dehydrogenase activity
C4F17_04635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4F17_04640	COG0583	DNA-binding transcription factor activity
C4F17_04645	COG1971	Probably functions as a manganese efflux pump
C4F17_04660	COG5002	protein histidine kinase activity
C4F17_04660	COG5001	Diguanylate cyclase
C4F17_04660	COG3447	MASE1 domain protein
C4F17_04670	COG2814	Major facilitator Superfamily
C4F17_04675	COG0583	DNA-binding transcription factor activity
C4F17_04695	COG1802	Transcriptional regulator
C4F17_04700	COG0247	lactate metabolic process
C4F17_04700	COG0277	FAD linked oxidase domain protein
C4F17_04710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4F17_04720	COG0583	DNA-binding transcription factor activity
C4F17_04730	COG0583	DNA-binding transcription factor activity
C4F17_04755	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_04770	COG2814	Major facilitator Superfamily
C4F17_04775	COG2814	Major facilitator Superfamily
C4F17_04780	COG2995	paraquat-inducible protein a
C4F17_04785	COG2995	paraquat-inducible protein a
C4F17_04790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4F17_04790	COG3008	intermembrane lipid transfer
C4F17_04800	COG0477	Major facilitator Superfamily
C4F17_04810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4F17_04820	COG0534	Mate efflux family protein
C4F17_04860	COG2201	protein-glutamate methylesterase activity
C4F17_04870	COG2183	response to ionizing radiation
C4F17_04900	COG1538	Outer membrane efflux protein
C4F17_04915	COG0745	RESPONSE REGULATOR receiver
C4F17_04940	COG1538	Outer membrane efflux protein
C4F17_04980	COG3501	Rhs element vgr protein
C4F17_05010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4F17_05015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4F17_05030	COG0084	hydrolase, TatD family'
C4F17_05035	COG0666	response to abiotic stimulus
C4F17_05070	COG1349	DNA-binding transcription factor activity
C4F17_05080	COG0420	3'-5' exonuclease activity
C4F17_05090	COG1388	LysM domain
C4F17_05090	COG4942	peptidase
C4F17_05105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4F17_05130	COG3206	protein involved in exopolysaccharide biosynthesis
C4F17_05130	COG0489	protein tyrosine kinase activity
C4F17_05135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4F17_05140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4F17_05175	COG0297	glycogen (starch) synthase activity
C4F17_05180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4F17_05185	COG2197	response regulator
C4F17_05205	COG0583	DNA-binding transcription factor activity
C4F17_05215	COG1116	anion transmembrane transporter activity
C4F17_05225	COG3360	Dodecin
C4F17_05240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_05265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4F17_05270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4F17_05270	COG1042	CoA-binding domain protein
C4F17_05270	COG0045	succinate-CoA ligase (ADP-forming) activity
C4F17_05280	COG3608	succinylglutamate desuccinylase aspartoacylase
C4F17_05295	COG0765	amino acid transport
C4F17_05300	COG0765	amino acid transport
C4F17_05310	COG2186	Transcriptional regulator
C4F17_05325	COG2197	response regulator
C4F17_05350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_05365	COG1126	abc transporter atp-binding protein
C4F17_05375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_05380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_05385	COG2205	protein histidine kinase activity
C4F17_05405	COG0583	DNA-binding transcription factor activity
C4F17_05410	COG2031	fatty acid transporter
C4F17_05420	COG2423	ornithine cyclodeaminase activity
C4F17_05435	COG0667	Aldo Keto reductase
C4F17_05460	COG2814	Major facilitator Superfamily
C4F17_05470	COG0251	oxidation-reduction process
C4F17_05475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4F17_05480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4F17_05485	COG2207	Transcriptional regulator
C4F17_05490	COG0667	Aldo Keto reductase
C4F17_05495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4F17_05530	COG0363	glucosamine-6-phosphate deaminase activity
C4F17_05550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4F17_05550	COG1199	ATP-dependent helicase activity
C4F17_05570	COG3437	response regulator, receiver
C4F17_05570	COG2205	protein histidine kinase activity
C4F17_05570	COG4999	Histidine kinase
C4F17_05570	COG3850	Histidine kinase
C4F17_05575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4F17_05585	COG2205	protein histidine kinase activity
C4F17_05585	COG0784	Response regulator, receiver
C4F17_05625	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4F17_05630	COG0590	tRNA wobble adenosine to inosine editing
C4F17_05655	COG4566	intracellular signal transduction
C4F17_05660	COG4191	Histidine kinase
C4F17_05680	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_05735	COG1902	pentaerythritol trinitrate reductase activity
C4F17_05745	COG0604	alcohol dehydrogenase
C4F17_05750	COG0596	Alpha beta hydrolase
C4F17_05755	COG0604	alcohol dehydrogenase
C4F17_05765	COG0519	Catalyzes the synthesis of GMP from XMP
C4F17_05765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4F17_05795	COG2867	negative regulation of translational initiation
C4F17_05800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4F17_05835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4F17_05840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4F17_05845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4F17_05850	COG2251	uridine kinase activity
C4F17_05850	COG0195	Participates in both transcription termination and antitermination
C4F17_05855	COG0779	Required for maturation of 30S ribosomal subunits
C4F17_05860	COG0477	Major facilitator Superfamily
C4F17_05865	COG4172	Belongs to the ABC transporter superfamily
C4F17_05870	COG4239	(ABC) transporter, permease
C4F17_05875	COG4174	ABC transporter (Permease)
C4F17_05885	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4F17_05890	COG1793	dna ligase
C4F17_05895	COG1982	Orn Lys Arg decarboxylase major
C4F17_05940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4F17_05950	COG0795	lipopolysaccharide-transporting ATPase activity
C4F17_05960	COG0583	DNA-binding transcription factor activity
C4F17_05965	COG0436	Aminotransferase
C4F17_05975	COG1643	Atp-dependent helicase
C4F17_05980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4F17_05980	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4F17_05985	COG1280	lysine exporter protein (LysE YggA)
C4F17_06000	COG2171	N-acyltransferase activity
C4F17_06010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4F17_06015	COG2890	protein-(glutamine-N5) methyltransferase activity
C4F17_06040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C4F17_06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_06090	COG3800	Transcriptional regulator
C4F17_06090	COG1396	sequence-specific DNA binding
C4F17_06095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4F17_06105	COG0477	Major facilitator Superfamily
C4F17_06120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4F17_06130	COG2885	chlorophyll binding
C4F17_06135	COG0823	Involved in the tonB-independent uptake of proteins
C4F17_06140	COG1132	(ABC) transporter
C4F17_06145	COG1530	ribonuclease E activity
C4F17_06150	COG0424	maF-like protein
C4F17_06155	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4F17_06160	COG0799	negative regulation of ribosome biogenesis
C4F17_06165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4F17_06170	COG0408	coproporphyrinogen oxidase activity
C4F17_06175	COG0151	Belongs to the GarS family
C4F17_06180	COG0217	transcriptional regulatory protein
C4F17_06185	COG2226	methyltransferase
C4F17_06190	COG0251	oxidation-reduction process
C4F17_06240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4F17_06255	COG0433	COG0433 Predicted ATPase
C4F17_06265	COG1595	DNA-templated transcription, initiation
C4F17_06280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4F17_06285	COG1744	ABC transporter substrate-binding protein PnrA-like
C4F17_06330	COG0402	S-adenosylhomocysteine deaminase activity
C4F17_06345	COG0110	maltose O-acetyltransferase activity
C4F17_06350	COG2925	Exonuclease
C4F17_06355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_06360	COG0542	response to heat
C4F17_06365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4F17_06390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4F17_06395	COG1570	exodeoxyribonuclease VII activity
C4F17_06400	COG0811	peptide transport
C4F17_06405	COG0848	biopolymer transport protein
C4F17_06410	COG1663	tetraacyldisaccharide 4'-kinase activity
C4F17_06415	COG2835	tetraacyldisaccharide 4'-kinase activity
C4F17_06420	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4F17_06425	COG0563	adenylate kinase activity
C4F17_06430	COG0252	asparaginase activity
C4F17_06435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4F17_06445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4F17_06450	COG2814	Major facilitator Superfamily
C4F17_06455	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_06460	COG1024	Enoyl-CoA hydratase
C4F17_06465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4F17_06480	COG0454	-acetyltransferase
C4F17_06485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4F17_06495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4F17_06500	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4F17_06505	COG1534	Rna-binding protein
C4F17_06520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4F17_06530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4F17_06535	COG0505	Belongs to the CarA family
C4F17_06540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4F17_06545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4F17_06550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4F17_06555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4F17_06560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4F17_06565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4F17_06580	COG0750	zinc metalloprotease
C4F17_06585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4F17_06590	COG0575	Belongs to the CDS family
C4F17_06595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4F17_06600	COG0233	cytoplasmic translational termination
C4F17_06605	COG0528	UMP kinase activity
C4F17_06610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4F17_06615	COG0052	Belongs to the universal ribosomal protein uS2 family
C4F17_06635	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4F17_06635	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4F17_06640	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_06645	COG0557	exoribonuclease II activity
C4F17_06660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4F17_06665	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C4F17_06680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4F17_06690	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_06705	COG0745	RESPONSE REGULATOR receiver
C4F17_06710	COG2205	protein histidine kinase activity
C4F17_06715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4F17_06715	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4F17_06720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4F17_06720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4F17_06725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4F17_06730	COG0560	Phosphoserine phosphatase
C4F17_06755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_06760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4F17_06770	COG0840	transmembrane signaling receptor activity
C4F17_06785	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4F17_06790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4F17_06795	COG1492	cobalamin metabolic process
C4F17_06805	COG1538	Outer membrane efflux protein
C4F17_06815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_06830	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4F17_06845	COG1346	cytolysis
C4F17_06860	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4F17_06880	COG0778	Nitroreductase
C4F17_06885	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C4F17_06895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4F17_06910	COG1797	cobyrinic acid a,c-diamide synthase activity
C4F17_06920	COG0038	chloride channel
C4F17_06935	COG0730	response to heat
C4F17_06945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4F17_06955	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_06975	COG1802	Transcriptional regulator
C4F17_06980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4F17_06985	COG0583	DNA-binding transcription factor activity
C4F17_06990	COG0129	dihydroxy-acid dehydratase activity
C4F17_07000	COG4654	Cytochrome c, class I
C4F17_07010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4F17_07020	COG0583	DNA-binding transcription factor activity
C4F17_07025	COG2910	NAD(P)H-binding
C4F17_07030	COG0114	fumarate hydratase activity
C4F17_07040	COG4176	ABC-type proline glycine betaine transport system permease component
C4F17_07045	COG2113	Glycine betaine
C4F17_07055	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4F17_07330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4F17_07335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4F17_07340	COG0740	serine-type endopeptidase activity
C4F17_07345	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4F17_07380	COG1562	ergosterol biosynthetic process
C4F17_07385	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C4F17_07395	COG1280	lysine exporter protein (LysE YggA)
C4F17_07405	COG1011	Hydrolase
C4F17_07410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4F17_07440	COG0410	ABC transporter
C4F17_07445	COG0411	ABC transporter
C4F17_07475	COG2204	response regulator
C4F17_07490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_07515	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_07525	COG0642	Histidine kinase
C4F17_07535	COG2326	polyphosphate kinase activity
C4F17_07550	COG4654	Cytochrome c, class I
C4F17_07555	COG4585	Histidine kinase
C4F17_07575	COG0527	aspartate kinase activity
C4F17_07580	COG0037	tRNA processing
C4F17_07585	COG0825	malonyl-CoA metabolic process
C4F17_07595	COG0215	cysteine-tRNA ligase activity
C4F17_07615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4F17_07640	COG0741	lytic transglycosylase activity
C4F17_07645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4F17_07650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4F17_07655	COG4968	Prepilin-type N-terminal cleavage methylation domain
C4F17_07685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4F17_07685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4F17_07700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4F17_07705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4F17_07710	COG0436	Aminotransferase
C4F17_07715	COG0824	Thioesterase
C4F17_07725	COG0848	biopolymer transport protein
C4F17_07785	COG2259	Doxx family
C4F17_07790	COG1741	Belongs to the pirin family
C4F17_07800	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4F17_07800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_07805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4F17_07810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4F17_07825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4F17_07855	COG0540	Belongs to the ATCase OTCase family
C4F17_07880	COG3842	ATPase activity
C4F17_07900	COG0784	Response regulator, receiver
C4F17_07900	COG2205	protein histidine kinase activity
C4F17_07900	COG2198	Histidine kinase
C4F17_07905	COG3437	response regulator, receiver
C4F17_07940	COG0784	Response regulator, receiver
C4F17_07945	COG4251	negative regulation of phosphorylation
C4F17_07960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4F17_07970	COG0308	aminopeptidase N
C4F17_07975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4F17_07980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4F17_08065	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_08070	COG0154	amidase activity
C4F17_08080	COG0583	DNA-binding transcription factor activity
C4F17_08105	COG0587	DNA-directed DNA polymerase activity
C4F17_08110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4F17_08130	COG0583	DNA-binding transcription factor activity
C4F17_08160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4F17_08200	COG3384	dioxygenase
C4F17_08230	COG1132	(ABC) transporter
C4F17_08240	COG1309	transcriptional regulator
C4F17_08250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4F17_08255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_08260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4F17_08270	COG1272	protein, Hemolysin III
C4F17_08310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4F17_08315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4F17_08325	COG0583	DNA-binding transcription factor activity
C4F17_08350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4F17_08350	COG0519	Catalyzes the synthesis of GMP from XMP
C4F17_08355	COG1183	phosphatidylcholine synthase activity
C4F17_08360	COG0625	glutathione transferase activity
C4F17_08385	COG2818	Glycosylase
C4F17_08395	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_08420	COG1462	curli production assembly transport component CsgG
C4F17_08465	COG0776	regulation of translation
C4F17_08470	COG0072	phenylalanine-tRNA ligase activity
C4F17_08470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4F17_08475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4F17_08480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4F17_08485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4F17_08490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4F17_08495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4F17_08520	COG2207	Transcriptional regulator
C4F17_08530	COG0028	Belongs to the TPP enzyme family
C4F17_08535	COG1309	transcriptional regulator
C4F17_08545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_08550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_08555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4F17_08565	COG0673	inositol 2-dehydrogenase activity
C4F17_08590	COG3214	Protein conserved in bacteria
C4F17_08595	COG4774	siderophore transport
C4F17_08600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4F17_08615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4F17_08620	COG0802	atpase or kinase
C4F17_08625	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4F17_08635	COG0586	Pfam SNARE associated Golgi protein
C4F17_08640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4F17_08650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4F17_08655	COG4181	ATPase activity
C4F17_08680	COG3795	YCII-related domain
C4F17_08685	COG4941	Belongs to the sigma-70 factor family
C4F17_08700	COG1397	ADP-ribosylglycohydrolase
C4F17_08705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4F17_08735	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_08775	COG1566	PFAM secretion protein HlyD family protein
C4F17_08785	COG1846	Transcriptional regulator
C4F17_08790	COG1132	(ABC) transporter
C4F17_08800	COG0494	nUDIX hydrolase
C4F17_08810	COG1007	ATP synthesis coupled electron transport
C4F17_08825	COG0713	ATP synthesis coupled electron transport
C4F17_08835	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4F17_08840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4F17_08845	COG1034	ATP synthesis coupled electron transport
C4F17_08860	COG0649	NAD binding
C4F17_08865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4F17_08870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4F17_08875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4F17_08890	COG0149	triose-phosphate isomerase activity
C4F17_08895	COG0604	alcohol dehydrogenase
C4F17_08895	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_08895	COG3321	synthase
C4F17_08900	COG1185	polyribonucleotide nucleotidyltransferase activity
C4F17_08905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4F17_08915	COG0683	leucine binding
C4F17_08930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4F17_08935	COG3707	response regulator
C4F17_08940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_08945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_08950	COG1116	anion transmembrane transporter activity
C4F17_08960	COG2223	nitrite transmembrane transporter activity
C4F17_08965	COG2815	serine threonine protein kinase
C4F17_08965	COG0515	serine threonine protein kinase
C4F17_08970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4F17_08980	COG0243	molybdopterin cofactor binding
C4F17_08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4F17_08995	COG3842	ATPase activity
C4F17_09005	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4F17_09010	COG3833	ABC-type maltose transport systems, permease component
C4F17_09030	COG0791	NLP P60 protein
C4F17_09035	COG2081	HI0933 family
C4F17_09040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4F17_09050	COG0494	nUDIX hydrolase
C4F17_09065	COG0312	modulator of DNA gyrase
C4F17_09070	COG3028	Belongs to the UPF0307 family
C4F17_09075	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4F17_09085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4F17_09120	COG0475	glutathione-regulated potassium exporter activity
C4F17_09135	COG1045	serine acetyltransferase
C4F17_09150	COG1289	transmembrane transporter activity
C4F17_09160	COG2311	Membrane
C4F17_09165	COG0583	DNA-binding transcription factor activity
C4F17_09180	COG3119	arylsulfatase activity
C4F17_09190	COG1074	ATP-dependent DNA helicase activity
C4F17_09225	COG1595	DNA-templated transcription, initiation
C4F17_09255	COG2375	cellular response to nickel ion
C4F17_09270	COG0598	Magnesium transport protein CorA
C4F17_09275	COG4251	negative regulation of phosphorylation
C4F17_09275	COG3706	GGDEF domain
C4F17_09275	COG2203	Gaf domain
C4F17_09275	COG5001	Diguanylate cyclase
C4F17_09280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4F17_09320	COG0601	transmembrane transport
C4F17_09325	COG0747	negative chemotaxis
C4F17_09330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_09345	COG4585	Histidine kinase
C4F17_09350	COG1968	undecaprenyl-diphosphatase activity
C4F17_09365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4F17_09370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4F17_09375	COG1737	Transcriptional regulator
C4F17_09390	COG1538	Outer membrane efflux protein
C4F17_09395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_09405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_09430	COG3275	phosphorelay sensor kinase activity
C4F17_09445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4F17_09485	COG0004	ammonium transporteR
C4F17_09515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4F17_09520	COG0517	IMP dehydrogenase activity
C4F17_09520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4F17_09530	COG0789	Transcriptional regulator
C4F17_09540	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_09545	COG2201	protein-glutamate methylesterase activity
C4F17_09550	COG2918	glutathione biosynthetic process
C4F17_09570	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_09580	COG0523	cobalamin synthesis protein
C4F17_09590	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_09645	COG2354	Protein conserved in bacteria
C4F17_09660	COG4628	conserved protein (DUF2132)
C4F17_09675	COG0564	pseudouridine synthase activity
C4F17_09680	COG0589	response to stress
C4F17_09700	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C4F17_09705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4F17_09710	COG1252	NADH dehydrogenase
C4F17_09715	COG1525	nuclease
C4F17_09725	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_09730	COG1764	response to oxidative stress
C4F17_09750	COG0765	amino acid transport
C4F17_09755	COG0765	amino acid transport
C4F17_09770	COG0454	-acetyltransferase
C4F17_09775	COG4191	Histidine kinase
C4F17_09775	COG0784	Response regulator, receiver
C4F17_09785	COG0584	glycerophosphoryl diester phosphodiesterase
C4F17_09805	COG2132	Multicopper oxidase
C4F17_09830	COG3191	aminopeptidase activity
C4F17_09840	COG0789	Transcriptional regulator
C4F17_09845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4F17_09850	COG0488	(ABC) transporter
C4F17_09855	COG0513	Belongs to the DEAD box helicase family
C4F17_09865	COG3842	ATPase activity
C4F17_09875	COG1175	transmembrane transport
C4F17_09885	COG2186	Transcriptional regulator
C4F17_09890	COG0129	dihydroxy-acid dehydratase activity
C4F17_09900	COG0800	Aldolase
C4F17_09905	COG0235	Class ii aldolase
C4F17_09915	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_09940	COG1840	ABC-type Fe3 transport system, periplasmic component
C4F17_09960	COG0346	lactoylglutathione lyase activity
C4F17_09975	COG0800	Aldolase
C4F17_10000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4F17_10005	COG0259	pyridoxamine-phosphate oxidase activity
C4F17_10035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4F17_10040	COG1309	transcriptional regulator
C4F17_10045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4F17_10065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4F17_10070	COG2169	Transcriptional regulator
C4F17_10080	COG0697	spore germination
C4F17_10095	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_10100	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_10105	COG3268	Saccharopine dehydrogenase
C4F17_10125	COG0625	glutathione transferase activity
C4F17_10165	COG2311	Membrane
C4F17_10210	COG2274	protein secretion by the type I secretion system
C4F17_10230	COG3850	Histidine kinase
C4F17_10230	COG5002	protein histidine kinase activity
C4F17_10240	COG1953	Uracil, thiamine, allantoin
C4F17_10265	COG2233	PERMEase
C4F17_10270	COG0656	L-ascorbic acid biosynthetic process
C4F17_10275	COG2205	protein histidine kinase activity
C4F17_10280	COG0473	3-isopropylmalate dehydrogenase activity
C4F17_10290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_10295	COG0444	Belongs to the ABC transporter superfamily
C4F17_10300	COG4608	Belongs to the ABC transporter superfamily
C4F17_10305	COG0747	negative chemotaxis
C4F17_10310	COG0154	amidase activity
C4F17_10320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4F17_10335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4F17_10355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4F17_10360	COG1605	Chorismate mutase
C4F17_10360	COG0077	Prephenate dehydratase
C4F17_10365	COG0287	Prephenate dehydrogenase
C4F17_10370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4F17_10390	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C4F17_10400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4F17_10405	COG2111	Na H antiporter
C4F17_10405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4F17_10410	COG1006	Multisubunit Na H antiporter MnhC subunit
C4F17_10415	COG0651	ATP synthesis coupled electron transport
C4F17_10425	COG2212	antiporter activity
C4F17_10430	COG1320	monovalent cation:proton antiporter activity
C4F17_10435	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4F17_10435	COG3608	succinylglutamate desuccinylase aspartoacylase
C4F17_10450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4F17_10500	COG4177	L-phenylalanine transmembrane transporter activity
C4F17_10505	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_10515	COG2188	Transcriptional regulator
C4F17_10555	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4F17_10565	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_10575	COG0411	ABC transporter
C4F17_10585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4F17_10590	COG0142	geranyltranstransferase activity
C4F17_10595	COG1722	exodeoxyribonuclease VII activity
C4F17_10635	COG3064	Membrane
C4F17_10660	COG0747	negative chemotaxis
C4F17_10665	COG0601	transmembrane transport
C4F17_10670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_10675	COG0444	Belongs to the ABC transporter superfamily
C4F17_10680	COG4608	Belongs to the ABC transporter superfamily
C4F17_10685	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4F17_10700	COG0412	Dienelactone hydrolase
C4F17_10715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_10740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4F17_10760	COG0210	DNA helicase
C4F17_10765	COG0516	GMP reductase activity
C4F17_10780	COG0300	oxidoreductase activity
C4F17_10795	COG0745	RESPONSE REGULATOR receiver
C4F17_10840	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_10860	COG0411	ABC transporter
C4F17_10890	COG0683	leucine binding
C4F17_10895	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_10900	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4F17_10925	COG4638	Rieske (2fe-2S)
C4F17_10950	COG0604	alcohol dehydrogenase
C4F17_10955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4F17_10960	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_10970	COG0513	Belongs to the DEAD box helicase family
C4F17_10975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4F17_10980	COG0501	Belongs to the peptidase M48B family
C4F17_10985	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4F17_10990	COG1162	GTPase activity
C4F17_11000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4F17_11005	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4F17_11015	COG0335	large ribosomal subunit rRNA binding
C4F17_11020	COG0336	Belongs to the RNA methyltransferase TrmD family
C4F17_11025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4F17_11030	COG0228	four-way junction DNA binding
C4F17_11045	COG0306	phosphate transporter
C4F17_11050	COG1392	Phosphate transport regulator
C4F17_11065	COG0617	tRNA 3'-terminal CCA addition
C4F17_11070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4F17_11075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4F17_11095	COG4977	sequence-specific DNA binding
C4F17_11095	COG1917	Cupin 2, conserved barrel domain protein
C4F17_11100	COG4941	Belongs to the sigma-70 factor family
C4F17_11105	COG3795	YCII-related domain
C4F17_11120	COG0728	peptidoglycan biosynthetic process
C4F17_11125	COG0268	Binds directly to 16S ribosomal RNA
C4F17_11135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4F17_11140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4F17_11155	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4F17_11165	COG3483	tryptophan 2,3-dioxygenase activity
C4F17_11175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_11185	COG1918	ferrous iron import across plasma membrane
C4F17_11185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C4F17_11195	COG2822	iron ion transport
C4F17_11205	COG2822	iron ion transport
C4F17_11220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4F17_11235	COG1960	acyl-CoA dehydrogenase activity
C4F17_11255	COG4106	trans-aconitate 2-methyltransferase activity
C4F17_11260	COG0039	L-malate dehydrogenase activity
C4F17_11265	COG2188	Transcriptional regulator
C4F17_11280	COG1053	succinate dehydrogenase
C4F17_11285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4F17_11290	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4F17_11295	COG0372	Belongs to the citrate synthase family
C4F17_11305	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4F17_11310	COG0066	3-isopropylmalate dehydratase activity
C4F17_11315	COG0473	3-isopropylmalate dehydrogenase activity
C4F17_11320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4F17_11330	COG0101	tRNA pseudouridine synthase activity
C4F17_11335	COG0135	phosphoribosylanthranilate isomerase activity
C4F17_11340	COG0133	tryptophan synthase activity
C4F17_11345	COG0159	tryptophan synthase activity
C4F17_11350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4F17_11355	COG0762	integral membrane protein
C4F17_11365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4F17_11370	COG0443	Heat shock 70 kDa protein
C4F17_11375	COG1451	nucleotide metabolic process
C4F17_11380	COG1472	Belongs to the glycosyl hydrolase 3 family
C4F17_11385	COG0736	holo-[acyl-carrier-protein] synthase activity
C4F17_11390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4F17_11395	COG1381	Involved in DNA repair and RecF pathway recombination
C4F17_11400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4F17_11405	COG0571	ribonuclease III activity
C4F17_11415	COG0681	Belongs to the peptidase S26 family
C4F17_11420	COG0481	GTPase activity
C4F17_11425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4F17_11450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4F17_11455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4F17_11460	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_11465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4F17_11470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4F17_11475	COG0416	fatty acid biosynthetic process
C4F17_11480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4F17_11485	COG1399	metal-binding, possibly nucleic acid-binding protein
C4F17_11490	COG0424	maF-like protein
C4F17_11495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4F17_11500	COG2223	nitrite transmembrane transporter activity
C4F17_11505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4F17_11505	COG0616	signal peptide processing
C4F17_11525	COG1530	ribonuclease E activity
C4F17_11545	COG0181	hydroxymethylbilane synthase activity
C4F17_11550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4F17_11560	COG3459	Glycosyltransferase 36 associated
C4F17_11580	COG0583	DNA-binding transcription factor activity
C4F17_11595	COG0628	permease
C4F17_11610	COG0165	Argininosuccinate lyase
C4F17_11625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_11635	COG1538	Outer membrane efflux protein
C4F17_11685	COG0346	lactoylglutathione lyase activity
C4F17_11750	COG1280	lysine exporter protein (LysE YggA)
C4F17_11760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4F17_11765	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4F17_11770	COG0583	DNA-binding transcription factor activity
C4F17_11775	COG2186	Transcriptional regulator
C4F17_11780	COG2807	transmembrane transport
C4F17_11790	COG4778	phosphonate C-P lyase system protein PhnL
C4F17_11815	COG2267	carboxylic ester hydrolase activity
C4F17_11825	COG4221	oxidoreductase activity
C4F17_11830	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4F17_11845	COG0583	DNA-binding transcription factor activity
C4F17_11850	COG1304	FMN binding
C4F17_11855	COG0477	Major facilitator Superfamily
C4F17_11870	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_11875	COG4948	Mandelate Racemase Muconate Lactonizing
C4F17_11885	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4F17_11900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4F17_11925	COG0583	DNA-binding transcription factor activity
C4F17_11940	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C4F17_11945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4F17_11975	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_11985	COG1960	acyl-CoA dehydrogenase activity
C4F17_11995	COG1960	acyl-CoA dehydrogenase activity
C4F17_12010	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_12015	COG4948	Mandelate Racemase Muconate Lactonizing
C4F17_12030	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_12035	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4F17_12035	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4F17_12040	COG2267	carboxylic ester hydrolase activity
C4F17_12055	COG3022	response to hydroperoxide
C4F17_12070	COG0425	Belongs to the sulfur carrier protein TusA family
C4F17_12075	COG2816	NAD+ diphosphatase activity
C4F17_12320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4F17_12500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4F17_12520	COG0411	ABC transporter
C4F17_12530	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_12535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4F17_12540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4F17_12545	COG1674	ftsk spoiiie
C4F17_12555	COG0492	ferredoxin-NADP+ reductase activity
C4F17_12560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4F17_12565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4F17_12575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4F17_12575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4F17_12595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4F17_12600	COG1960	acyl-CoA dehydrogenase activity
C4F17_12625	COG0196	riboflavin kinase activity
C4F17_12635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4F17_12640	COG1609	Transcriptional regulator
C4F17_12665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4F17_12670	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4F17_12680	COG0583	DNA-binding transcription factor activity
C4F17_12700	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_12720	COG0583	DNA-binding transcription factor activity
C4F17_12740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4F17_12745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4F17_12760	COG0084	hydrolase, TatD family'
C4F17_12765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4F17_12770	COG0714	Associated with various cellular activities
C4F17_12780	COG2304	oxidoreductase activity
C4F17_12795	COG0583	DNA-binding transcription factor activity
C4F17_12805	COG1309	transcriptional regulator
C4F17_12815	COG1024	Enoyl-CoA hydratase
C4F17_12820	COG2050	protein possibly involved in aromatic compounds catabolism
C4F17_12830	COG3396	Phenylacetate-CoA oxygenase
C4F17_12835	COG3460	Phenylacetate-CoA oxygenase
C4F17_12840	COG3396	Phenylacetate-CoA oxygenase
C4F17_12845	COG2151	metal-sulfur cluster biosynthetic enzyme
C4F17_12850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4F17_12875	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_12875	COG2030	dehydratase
C4F17_12880	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_12895	COG0671	phosphoesterase, PA-phosphatase related
C4F17_12900	COG0463	Glycosyl transferase, family 2
C4F17_12905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4F17_12925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4F17_12930	COG1253	flavin adenine dinucleotide binding
C4F17_12985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4F17_13000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4F17_13030	COG0601	transmembrane transport
C4F17_13045	COG0251	oxidation-reduction process
C4F17_13050	COG0740	serine-type endopeptidase activity
C4F17_13055	COG1595	DNA-templated transcription, initiation
C4F17_13065	COG1136	(ABC) transporter
C4F17_13070	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4F17_13095	COG2969	positive regulation of protein catabolic process
C4F17_13100	COG0625	glutathione transferase activity
C4F17_13105	COG2857	Cytochrome c1
C4F17_13110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4F17_13115	COG0723	plastoquinol--plastocyanin reductase activity
C4F17_13135	COG1970	mechanosensitive ion channel activity
C4F17_13140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4F17_13145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4F17_13160	COG0805	protein transport
C4F17_13165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4F17_13170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4F17_13175	COG0537	adenosine 5'-monophosphoramidase activity
C4F17_13185	COG0140	phosphoribosyl-ATP diphosphatase activity
C4F17_13190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4F17_13195	COG0107	imidazoleglycerol-phosphate synthase activity
C4F17_13205	COG1301	dicarboxylic acid transport
C4F17_13220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4F17_13225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4F17_13230	COG0131	Imidazoleglycerol-phosphate dehydratase
C4F17_13235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4F17_13255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4F17_13260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4F17_13265	COG5007	Belongs to the BolA IbaG family
C4F17_13270	COG0842	Transport permease protein
C4F17_13275	COG1131	(ABC) transporter
C4F17_13290	COG2853	Lipoprotein
C4F17_13295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4F17_13300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4F17_13305	COG1127	ABC transporter
C4F17_13315	COG0067	glutamate synthase
C4F17_13315	COG0069	glutamate synthase activity
C4F17_13315	COG0070	glutamate synthase
C4F17_13345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C4F17_13350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4F17_13355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4F17_13390	COG1965	Belongs to the frataxin family
C4F17_13400	COG0019	diaminopimelate decarboxylase activity
C4F17_13405	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4F17_13410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4F17_13415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4F17_13420	COG1333	cytochrome c biogenesis protein
C4F17_13430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4F17_13435	COG2267	carboxylic ester hydrolase activity
C4F17_13440	COG1560	Kdo2-lipid A biosynthetic process
C4F17_13450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4F17_13475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_13480	COG4772	TonB-dependent receptor
C4F17_13500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_13505	COG0745	RESPONSE REGULATOR receiver
C4F17_13510	COG0642	Histidine kinase
C4F17_13530	COG4774	siderophore transport
C4F17_13540	COG1595	DNA-templated transcription, initiation
C4F17_13545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4F17_13550	COG0459	protein refolding
C4F17_13570	COG1070	Carbohydrate kinase
C4F17_13575	COG2207	Transcriptional regulator
C4F17_13575	COG4753	response regulator
C4F17_13585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4F17_13595	COG0246	Mannitol dehydrogenase
C4F17_13600	COG3842	ATPase activity
C4F17_13605	COG0395	ABC-type sugar transport system, permease component
C4F17_13640	COG0166	Belongs to the GPI family
C4F17_13645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4F17_13660	COG3842	ATPase activity
C4F17_13670	COG1840	ABC-type Fe3 transport system, periplasmic component
C4F17_13675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4F17_13680	COG3384	dioxygenase
C4F17_13685	COG4608	Belongs to the ABC transporter superfamily
C4F17_13690	COG0444	Belongs to the ABC transporter superfamily
C4F17_13695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_13720	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4F17_13725	COG1765	OsmC-like protein
C4F17_13740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4F17_13820	COG2863	cytochrome
C4F17_13830	COG2271	Major facilitator Superfamily
C4F17_13835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4F17_13850	COG3842	ATPase activity
C4F17_13855	COG1840	ABC-type Fe3 transport system, periplasmic component
C4F17_13865	COG4178	(ABC) transporter
C4F17_13870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4F17_13880	COG1785	Belongs to the alkaline phosphatase family
C4F17_13900	COG1132	(ABC) transporter
C4F17_13910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4F17_13910	COG0189	ligase activity
C4F17_13940	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4F17_13945	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4F17_13950	COG1129	ABC transporter
C4F17_13955	COG4214	carbohydrate transport
C4F17_13965	COG4213	ABC transporter substrate-binding protein
C4F17_13970	COG1879	ABC-type sugar transport system periplasmic component
C4F17_13975	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_13985	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_13990	COG3386	PFAM SMP-30 Gluconolaconase
C4F17_14005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4F17_14035	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4F17_14040	COG2267	carboxylic ester hydrolase activity
C4F17_14045	COG1228	amidohydrolase
C4F17_14065	COG1902	pentaerythritol trinitrate reductase activity
C4F17_14085	COG0506	proline dehydrogenase activity
C4F17_14085	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4F17_14085	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4F17_14095	COG2832	Protein of unknown function (DUF454)
C4F17_14105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4F17_14115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4F17_14125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_14130	COG0183	Belongs to the thiolase family
C4F17_14135	COG1024	Enoyl-CoA hydratase
C4F17_14160	COG0583	DNA-binding transcription factor activity
C4F17_14165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4F17_14180	COG0583	DNA-binding transcription factor activity
C4F17_14185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4F17_14190	COG0741	lytic transglycosylase activity
C4F17_14195	COG1285	pathogenesis
C4F17_14200	COG0625	glutathione transferase activity
C4F17_14205	COG3047	cAMP biosynthetic process
C4F17_14210	COG0617	tRNA 3'-terminal CCA addition
C4F17_14220	COG3387	PFAM Glycoside hydrolase 15-related
C4F17_14225	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C4F17_14255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_14260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4F17_14270	COG2175	clavaminate synthase activity
C4F17_14285	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_14295	COG0037	tRNA processing
C4F17_14310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_14315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_14325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4F17_14330	COG2205	protein histidine kinase activity
C4F17_14340	COG2204	response regulator
C4F17_14355	COG4993	Dehydrogenase
C4F17_14370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4F17_14405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4F17_14425	COG2264	protein methyltransferase activity
C4F17_14430	COG0439	Biotin carboxylase
C4F17_14435	COG0511	ligase activity, forming carbon-carbon bonds
C4F17_14440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4F17_14450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4F17_14460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4F17_14470	COG0312	modulator of DNA gyrase
C4F17_14475	COG0772	Belongs to the SEDS family
C4F17_14485	COG2197	response regulator
C4F17_14490	COG3150	esterase
C4F17_14505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4F17_14525	COG0575	Belongs to the CDS family
C4F17_14530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4F17_14535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4F17_14540	COG0583	DNA-binding transcription factor activity
C4F17_14545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4F17_14560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4F17_14565	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4F17_14570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4F17_14575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4F17_14580	COG0772	Belongs to the SEDS family
C4F17_14585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4F17_14590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4F17_14595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4F17_14600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4F17_14615	COG0275	rRNA processing
C4F17_14620	COG2001	Belongs to the MraZ family
C4F17_14625	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4F17_14630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4F17_14640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4F17_14650	COG0523	cobalamin synthesis protein
C4F17_14655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4F17_14660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4F17_14675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4F17_14690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C4F17_14700	COG1335	isochorismatase
C4F17_14705	COG0583	DNA-binding transcription factor activity
C4F17_14720	COG1595	DNA-templated transcription, initiation
C4F17_14730	COG2366	antibiotic biosynthetic process
C4F17_14775	COG2814	Major facilitator Superfamily
C4F17_14795	COG0590	tRNA wobble adenosine to inosine editing
C4F17_14810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4F17_14845	COG1187	pseudouridine synthase activity
C4F17_14855	COG2814	Major facilitator Superfamily
C4F17_14865	COG1566	PFAM secretion protein HlyD family protein
C4F17_14895	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4F17_14905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4F17_14915	COG0501	Belongs to the peptidase M48B family
C4F17_14930	COG0418	dihydroorotase activity
C4F17_14940	COG1573	uracil-dna glycosylase
C4F17_14955	COG1881	PFAM PEBP family protein
C4F17_14965	COG0583	DNA-binding transcription factor activity
C4F17_14970	COG1024	Enoyl-CoA hydratase
C4F17_14970	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_14975	COG0183	Belongs to the thiolase family
C4F17_14980	COG1960	acyl-CoA dehydrogenase activity
C4F17_14985	COG1960	acyl-CoA dehydrogenase activity
C4F17_14990	COG1024	Enoyl-CoA hydratase
C4F17_14995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_15000	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_15005	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_15035	COG3586	endonuclease activity
C4F17_15045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4F17_15055	COG4804	nuclease activity
C4F17_15065	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C4F17_15075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4F17_15085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_15120	COG1053	succinate dehydrogenase
C4F17_15120	COG3976	FMN-binding domain protein
C4F17_15120	COG0431	NADPH-dependent FMN reductase
C4F17_15130	COG1126	abc transporter atp-binding protein
C4F17_15140	COG0765	amino acid transport
C4F17_15145	COG0765	amino acid transport
C4F17_15150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4F17_15155	COG1027	Aspartate ammonia-lyase
C4F17_15160	COG0583	DNA-binding transcription factor activity
C4F17_15165	COG0154	amidase activity
C4F17_15170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4F17_15175	COG5265	(ABC) transporter
C4F17_15180	COG1607	acyl-coa hydrolase
C4F17_15185	COG0683	leucine binding
C4F17_15190	COG1024	Enoyl-CoA hydratase
C4F17_15210	COG0183	Belongs to the thiolase family
C4F17_15215	COG2852	Protein conserved in bacteria
C4F17_15220	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_15220	COG1024	Enoyl-CoA hydratase
C4F17_15230	COG1960	acyl-CoA dehydrogenase activity
C4F17_15255	COG4221	oxidoreductase activity
C4F17_15260	COG0583	DNA-binding transcription factor activity
C4F17_15265	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4F17_15270	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_15280	COG2721	sulfolactate sulfo-lyase activity
C4F17_15290	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4F17_15300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4F17_15320	COG1215	transferase activity, transferring glycosyl groups
C4F17_15325	COG1216	Glycosyl transferase, family 2
C4F17_15325	COG0438	transferase activity, transferring glycosyl groups
C4F17_15350	COG0297	glycogen (starch) synthase activity
C4F17_15355	COG0463	Glycosyl transferase, family 2
C4F17_15370	COG1216	Glycosyl transferase, family 2
C4F17_15375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4F17_15385	COG0463	Glycosyl transferase, family 2
C4F17_15395	COG3958	Transketolase
C4F17_15400	COG3959	Transketolase, thiamine diphosphate binding domain
C4F17_15420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4F17_15445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4F17_15465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_15485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_15495	COG0697	spore germination
C4F17_15500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_15510	COG0384	phenazine biosynthesis protein PhzF
C4F17_15515	COG0625	glutathione transferase activity
C4F17_15520	COG0384	phenazine biosynthesis protein PhzF
C4F17_15535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4F17_15550	COG0726	polysaccharide deacetylase
C4F17_15550	COG1649	PFAM Uncharacterised BCR, COG1649
C4F17_15555	COG1215	transferase activity, transferring glycosyl groups
C4F17_15565	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_15570	COG0583	DNA-binding transcription factor activity
C4F17_15590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4F17_15595	COG4232	protein-disulfide reductase activity
C4F17_15600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4F17_15605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4F17_15615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4F17_15620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4F17_15640	COG0679	Auxin Efflux Carrier
C4F17_15645	COG0210	DNA helicase
C4F17_15660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4F17_15675	COG1360	Flagellar Motor Protein
C4F17_15690	COG4774	siderophore transport
C4F17_15695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4F17_15700	COG0390	transport system, permease component
C4F17_15725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4F17_15725	COG2205	protein histidine kinase activity
C4F17_15730	COG2050	protein possibly involved in aromatic compounds catabolism
C4F17_15735	COG0392	lysyltransferase activity
C4F17_15750	COG2204	response regulator
C4F17_15755	COG5000	phosphorelay sensor kinase activity
C4F17_15775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4F17_15780	COG0085	RNA polymerase activity
C4F17_15785	COG0222	ribosome binding
C4F17_15790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4F17_15795	COG0081	regulation of translation
C4F17_15800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4F17_15840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4F17_15845	COG0134	indole-3-glycerol-phosphate synthase activity
C4F17_15850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4F17_15885	COG0546	phosphoglycolate phosphatase activity
C4F17_15895	COG3781	membrane
C4F17_15900	COG1959	2 iron, 2 sulfur cluster binding
C4F17_15905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_15930	COG2144	transferase activity, transferring acyl groups
C4F17_15940	COG2072	flavoprotein involved in K transport
C4F17_16035	COG3501	Rhs element vgr protein
C4F17_16060	COG3501	Rhs element vgr protein
C4F17_16115	COG0515	serine threonine protein kinase
C4F17_16145	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C4F17_16150	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C4F17_16165	COG5002	protein histidine kinase activity
C4F17_16230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4F17_16235	COG2967	ApaG domain
C4F17_16250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4F17_16290	COG3318	Belongs to the UPF0149 family
C4F17_16290	COG3012	SEC-C Motif Domain Protein
C4F17_16295	COG0069	glutamate synthase activity
C4F17_16335	COG5002	protein histidine kinase activity
C4F17_16340	COG3038	cytochrome b561
C4F17_16365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_16370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4F17_16375	COG1137	ATPase activity
C4F17_16380	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4F17_16385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4F17_16395	COG0018	arginyl-trna synthetase
C4F17_16420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_16425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4F17_16430	COG1414	Transcriptional regulator
C4F17_16440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4F17_16445	COG4804	nuclease activity
C4F17_16460	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C4F17_16465	COG0583	DNA-binding transcription factor activity
C4F17_16475	COG0183	Belongs to the thiolase family
C4F17_16480	COG1024	Enoyl-CoA hydratase
C4F17_16485	COG0205	6-phosphofructokinase activity
C4F17_16500	COG2814	Major facilitator Superfamily
C4F17_16510	COG0121	glutamine amidotransferase
C4F17_16520	COG0189	ligase activity
C4F17_16535	COG3158	transport of potassium into the cell
C4F17_16545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4F17_16560	COG0495	leucyl-tRNA aminoacylation
C4F17_16575	COG0366	Alpha amylase catalytic
C4F17_16580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4F17_16585	COG1523	belongs to the glycosyl hydrolase 13 family
C4F17_16590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4F17_16595	COG0297	glycogen (starch) synthase activity
C4F17_16600	COG0058	SHG alpha-glucan phosphorylase activity
C4F17_16620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4F17_16625	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4F17_16630	COG0735	belongs to the Fur family
C4F17_16635	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4F17_16645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4F17_16655	COG0598	Magnesium transport protein CorA
C4F17_16660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4F17_16665	COG0747	negative chemotaxis
C4F17_16670	COG4608	Belongs to the ABC transporter superfamily
C4F17_16675	COG0444	Belongs to the ABC transporter superfamily
C4F17_16680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_16685	COG0601	transmembrane transport
C4F17_16690	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_16695	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C4F17_16700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4F17_16705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4F17_16725	COG0482	sulfurtransferase activity
C4F17_16730	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_16735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_16780	COG1268	BioY protein
C4F17_16790	COG1122	ATPase activity
C4F17_16810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4F17_16815	COG0583	DNA-binding transcription factor activity
C4F17_16825	COG0217	transcriptional regulatory protein
C4F17_16830	COG0629	single-stranded DNA binding
C4F17_16835	COG0038	chloride channel
C4F17_16850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4F17_16855	COG1070	Carbohydrate kinase
C4F17_16865	COG1129	ABC transporter
C4F17_16870	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4F17_16875	COG0667	Aldo Keto reductase
C4F17_16910	COG0411	ABC transporter
C4F17_16915	COG1129	ABC transporter
C4F17_16920	COG0659	secondary active sulfate transmembrane transporter activity
C4F17_16925	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_16935	COG1053	succinate dehydrogenase
C4F17_16940	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_16945	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_16950	COG0410	ABC transporter
C4F17_16960	COG4177	L-phenylalanine transmembrane transporter activity
C4F17_16965	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_16975	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_16985	COG1946	Acyl-CoA thioesterase
C4F17_16995	COG0445	tRNA wobble uridine modification
C4F17_17000	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_17010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_17025	COG0583	DNA-binding transcription factor activity
C4F17_17055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_17070	COG0243	molybdopterin cofactor binding
C4F17_17085	COG1473	amidohydrolase
C4F17_17100	COG2733	membrane
C4F17_17115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4F17_17130	COG1960	acyl-CoA dehydrogenase activity
C4F17_17135	COG1960	acyl-CoA dehydrogenase activity
C4F17_17140	COG0513	Belongs to the DEAD box helicase family
C4F17_17145	COG0023	Translation Initiation Factor
C4F17_17155	COG0724	RNA recognition motif
C4F17_17175	COG0004	ammonium transporteR
C4F17_17215	COG3842	ATPase activity
C4F17_17220	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4F17_17225	COG1177	transmembrane transport
C4F17_17240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_17275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4F17_17280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4F17_17300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4F17_17315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_17325	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4F17_17335	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4F17_17340	COG0768	penicillin binding
C4F17_17350	COG1792	Involved in formation and maintenance of cell shape
C4F17_17355	COG1077	Cell shape determining protein MreB Mrl
C4F17_17360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4F17_17365	COG0154	amidase activity
C4F17_17370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4F17_17380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4F17_17385	COG0708	Exodeoxyribonuclease III
C4F17_17390	COG0583	DNA-binding transcription factor activity
C4F17_17420	COG1335	isochorismatase
C4F17_17425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4F17_17465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_17470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_17480	COG0501	Belongs to the peptidase M48B family
C4F17_17485	COG2223	nitrite transmembrane transporter activity
C4F17_17500	COG0579	oxidoreductase
C4F17_17505	COG0745	RESPONSE REGULATOR receiver
C4F17_17510	COG2205	protein histidine kinase activity
C4F17_17535	COG2974	May be involved in recombination
C4F17_17540	COG1473	amidohydrolase
C4F17_17550	COG0583	DNA-binding transcription factor activity
C4F17_17565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4F17_17585	COG1846	Transcriptional regulator
C4F17_17600	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_17625	COG3971	2-oxopent-4-enoate hydratase activity
C4F17_17640	COG0129	dihydroxy-acid dehydratase activity
C4F17_17655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4F17_17660	COG0789	Transcriptional regulator
C4F17_17680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4F17_17685	COG0477	Major facilitator Superfamily
C4F17_17695	COG0386	Belongs to the glutathione peroxidase family
C4F17_17705	COG0247	lactate metabolic process
C4F17_17710	COG0277	FAD linked oxidase domain protein
C4F17_17715	COG0277	FAD linked oxidase domain protein
C4F17_17720	COG0583	DNA-binding transcription factor activity
C4F17_17730	COG0004	ammonium transporteR
C4F17_17735	COG0347	Belongs to the P(II) protein family
C4F17_17745	COG0606	chelatase, subunit chli
C4F17_17820	COG3501	Rhs element vgr protein
C4F17_17880	COG2010	Cytochrome c
C4F17_17880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4F17_17885	COG2080	2 iron, 2 sulfur cluster binding
C4F17_17895	COG1335	isochorismatase
C4F17_17905	COG0411	ABC transporter
C4F17_17915	COG0683	leucine binding
C4F17_17945	COG1309	transcriptional regulator
C4F17_17970	COG0646	methionine synthase
C4F17_17970	COG1410	methionine synthase
C4F17_17975	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4F17_17980	COG5380	lipid catabolic process
C4F17_17990	COG0583	DNA-binding transcription factor activity
C4F17_18010	COG0402	S-adenosylhomocysteine deaminase activity
C4F17_18015	COG1228	amidohydrolase
C4F17_18040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4F17_18045	COG2986	histidine ammonia-lyase
C4F17_18055	COG1116	anion transmembrane transporter activity
C4F17_18060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_18075	COG0583	DNA-binding transcription factor activity
C4F17_18090	COG1957	nucleoside hydrolase
C4F17_18100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4F17_18105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4F17_18110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C4F17_18180	COG0633	Ferredoxin
C4F17_18185	COG0683	leucine binding
C4F17_18205	COG0410	ABC transporter
C4F17_18215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_18220	COG0700	Nucleoside recognition
C4F17_18225	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C4F17_18235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4F17_18245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_18265	COG0583	DNA-binding transcription factor activity
C4F17_18275	COG2066	Belongs to the glutaminase family
C4F17_18305	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_18320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4F17_18345	COG0583	DNA-binding transcription factor activity
C4F17_18365	COG1609	Transcriptional regulator
C4F17_18370	COG3485	protocatechuate 3,4-dioxygenase
C4F17_18375	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_18380	COG3246	L-lysine catabolic process to acetate
C4F17_18405	COG1573	uracil-dna glycosylase
C4F17_18415	COG1760	l-serine dehydratase
C4F17_18420	COG1473	amidohydrolase
C4F17_18440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_18445	COG1960	acyl-CoA dehydrogenase activity
C4F17_18450	COG0583	DNA-binding transcription factor activity
C4F17_18470	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4F17_18480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4F17_18495	COG1116	anion transmembrane transporter activity
C4F17_18495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_18500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_18505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_18510	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4F17_18565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4F17_18620	COG3284	Transcriptional regulator
C4F17_18645	COG3246	L-lysine catabolic process to acetate
C4F17_18655	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_18660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4F17_18680	COG2050	protein possibly involved in aromatic compounds catabolism
C4F17_18685	COG2233	PERMEase
C4F17_18690	COG0850	regulation of cytokinetic process
C4F17_18695	COG2894	cell division
C4F17_18700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4F17_18725	COG0583	DNA-binding transcription factor activity
C4F17_18750	COG0411	ABC transporter
C4F17_18785	COG2096	Adenosyltransferase
C4F17_18790	COG0277	FAD linked oxidase domain protein
C4F17_18800	COG1475	DNA binding
C4F17_18810	COG1192	Involved in chromosome partitioning
C4F17_18820	COG0357	Ribosomal RNA small subunit methyltransferase G
C4F17_18825	COG0445	tRNA wobble uridine modification
C4F17_18845	COG1024	Enoyl-CoA hydratase
C4F17_18855	COG1902	pentaerythritol trinitrate reductase activity
C4F17_18870	COG0346	lactoylglutathione lyase activity
C4F17_18875	COG0642	Histidine kinase
C4F17_18880	COG0745	RESPONSE REGULATOR receiver
C4F17_18890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4F17_18905	COG0456	acetyltransferase
C4F17_18910	COG2217	Heavy metal translocating P-type atpase
C4F17_18915	COG2608	mercury ion transmembrane transporter activity
C4F17_18930	COG0745	RESPONSE REGULATOR receiver
C4F17_18935	COG2205	protein histidine kinase activity
C4F17_18950	COG1472	Belongs to the glycosyl hydrolase 3 family
C4F17_18955	COG4452	Inner membrane protein CreD
C4F17_18975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4F17_18980	COG0456	acetyltransferase
C4F17_18980	COG0454	-acetyltransferase
C4F17_19005	COG3568	Endonuclease Exonuclease Phosphatase
C4F17_19010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_19015	COG0392	lysyltransferase activity
C4F17_19020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4F17_19030	COG1408	metallophosphoesterase
C4F17_19055	COG0187	DNA topoisomerase II activity
C4F17_19060	COG0592	DNA-directed DNA polymerase activity
C4F17_19065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4F17_19070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4F17_19075	COG0594	ribonuclease P activity
C4F17_19080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4F17_19085	COG0706	membrane insertase activity
C4F17_19090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4F17_19095	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C4F17_19095	COG2066	Belongs to the glutaminase family
C4F17_19115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4F17_19125	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_19130	COG0724	RNA recognition motif
C4F17_19135	COG2119	membrane
C4F17_19145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4F17_19145	COG2813	Specifically methylates the guanine in position
C4F17_19150	COG1739	Uncharacterized protein family UPF0029
C4F17_19155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4F17_19175	COG2267	carboxylic ester hydrolase activity
C4F17_19180	COG3831	ATPase activity
C4F17_19195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4F17_19205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4F17_19210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4F17_19215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4F17_19230	COG0280	phosphate acetyltransferase
C4F17_19230	COG0281	malic enzyme
C4F17_19250	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4F17_19275	COG2373	Large extracellular alpha-helical protein
C4F17_19280	COG4953	penicillin-binding protein 1C
C4F17_19305	COG0006	proline dipeptidase activity
C4F17_19315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C4F17_19320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4F17_19325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4F17_19330	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4F17_19335	COG1914	H( )-stimulated, divalent metal cation uptake system
C4F17_19340	COG0583	DNA-binding transcription factor activity
C4F17_19350	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_19380	COG1047	Peptidyl-prolyl cis-trans
C4F17_19385	COG0583	DNA-binding transcription factor activity
C4F17_19395	COG1741	Belongs to the pirin family
C4F17_19400	COG1473	amidohydrolase
C4F17_19415	COG3550	peptidyl-serine autophosphorylation
C4F17_19425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4F17_19440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4F17_19470	COG1802	Transcriptional regulator
C4F17_19475	COG1942	4-Oxalocrotonate Tautomerase
C4F17_19480	COG0697	spore germination
C4F17_19500	COG0513	Belongs to the DEAD box helicase family
C4F17_19505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4F17_19515	COG2814	Major facilitator Superfamily
C4F17_19535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4F17_19550	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_19575	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4F17_19575	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4F17_19585	COG0642	Histidine kinase
C4F17_19600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4F17_19605	COG2137	regulation of response to DNA damage stimulus
C4F17_19625	COG1126	abc transporter atp-binding protein
C4F17_19635	COG0765	amino acid transport
C4F17_19640	COG2721	sulfolactate sulfo-lyase activity
C4F17_19655	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_19660	COG1414	Transcriptional regulator
C4F17_19670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4F17_19675	COG0045	succinate-CoA ligase (ADP-forming) activity
C4F17_19680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4F17_19685	COG0861	Integral membrane protein TerC family
C4F17_19695	COG1716	ATPase activity
C4F17_19720	COG2194	sulfuric ester hydrolase activity
C4F17_19780	COG2165	general secretion pathway protein
C4F17_19785	COG0315	cyclic pyranopterin monophosphate synthase activity
C4F17_19790	COG4783	chaperone-mediated protein folding
C4F17_19795	COG1950	PFAM Membrane protein of
C4F17_19805	COG0861	Integral membrane protein TerC family
C4F17_19820	COG4681	YaeQ
C4F17_19830	COG0625	glutathione transferase activity
C4F17_19850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4F17_19875	COG1595	DNA-templated transcription, initiation
C4F17_19880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4F17_19890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4F17_19900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4F17_19910	COG4566	intracellular signal transduction
C4F17_19935	COG1522	sequence-specific DNA binding
C4F17_19945	COG2186	Transcriptional regulator
C4F17_19950	COG2084	Dehydrogenase
C4F17_19955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4F17_19960	COG3395	kinase activity
C4F17_19965	COG0235	Class ii aldolase
C4F17_19970	COG3622	Belongs to the hyi family
C4F17_19980	COG0251	oxidation-reduction process
C4F17_20010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_20025	COG2814	Major facilitator Superfamily
C4F17_20030	COG0765	amino acid transport
C4F17_20045	COG1522	sequence-specific DNA binding
C4F17_20060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4F17_20065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4F17_20075	COG2922	Belongs to the Smg family
C4F17_20080	COG0758	DNA mediated transformation
C4F17_20090	COG0242	peptide deformylase activity
C4F17_20100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4F17_20130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_20145	COG0583	DNA-binding transcription factor activity
C4F17_20150	COG0126	phosphoglycerate kinase activity
C4F17_20155	COG0469	pyruvate kinase activity
C4F17_20160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4F17_20165	COG1522	sequence-specific DNA binding
C4F17_20180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4F17_20195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4F17_20200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C4F17_20205	COG0009	L-threonylcarbamoyladenylate synthase
C4F17_20215	COG2027	D-alanyl-D-alanine carboxypeptidase
C4F17_20220	COG0494	nUDIX hydrolase
C4F17_20225	COG1349	DNA-binding transcription factor activity
C4F17_20230	COG1214	PFAM Peptidase M22, glycoprotease
C4F17_20245	COG0284	orotidine-5'-phosphate decarboxylase activity
C4F17_20300	COG0343	queuine tRNA-ribosyltransferase activity
C4F17_20305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4F17_20315	COG1090	epimerase
C4F17_20320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4F17_20325	COG1280	lysine exporter protein (LysE YggA)
C4F17_20345	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C4F17_20350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4F17_20355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4F17_20360	COG4770	biotin carboxylase activity
C4F17_20370	COG0783	Belongs to the Dps family
C4F17_20375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4F17_20395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4F17_20400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4F17_20405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4F17_20410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4F17_20415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4F17_20420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4F17_20425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4F17_20430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4F17_20435	COG1841	ribosomal large subunit assembly
C4F17_20440	COG0200	Binds to the 23S rRNA
C4F17_20445	COG0201	protein transport
C4F17_20450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4F17_20455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4F17_20460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4F17_20465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4F17_20470	COG0202	RNA polymerase activity
C4F17_20475	COG0203	ribosomal protein L17
C4F17_20495	COG1960	acyl-CoA dehydrogenase activity
C4F17_20500	COG1024	Enoyl-CoA hydratase
C4F17_20515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4F17_20530	COG0583	DNA-binding transcription factor activity
C4F17_20535	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_20545	COG0022	dehydrogenase e1 component
C4F17_20550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4F17_20560	COG0024	Methionine aminopeptidase
C4F17_20565	COG2197	response regulator
C4F17_20570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_20590	COG4213	ABC transporter substrate-binding protein
C4F17_20595	COG4214	carbohydrate transport
C4F17_20600	COG1129	ABC transporter
C4F17_20605	COG1940	carbohydrate kinase activity
C4F17_20635	COG0693	protein deglycase activity
C4F17_20640	COG0372	Belongs to the citrate synthase family
C4F17_20645	COG0372	Belongs to the citrate synthase family
C4F17_20655	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_20685	COG0411	ABC transporter
C4F17_20690	COG1022	Amp-dependent synthetase and ligase
C4F17_20695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4F17_20705	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_20725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4F17_20740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_20755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4F17_20760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4F17_20765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4F17_20775	COG2205	protein histidine kinase activity
C4F17_20780	COG0745	RESPONSE REGULATOR receiver
C4F17_20800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4F17_20810	COG1056	cytidyltransferase-related domain
C4F17_20810	COG1051	belongs to the nudix hydrolase family
C4F17_20815	COG1187	pseudouridine synthase activity
C4F17_20825	COG0745	RESPONSE REGULATOR receiver
C4F17_20845	COG0583	DNA-binding transcription factor activity
C4F17_20850	COG1840	ABC-type Fe3 transport system, periplasmic component
C4F17_20860	COG0326	Molecular chaperone. Has ATPase activity
C4F17_20880	COG0714	Associated with various cellular activities
C4F17_20885	COG0326	Molecular chaperone. Has ATPase activity
C4F17_20895	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C4F17_20900	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C4F17_20940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_20945	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_20950	COG1960	acyl-CoA dehydrogenase activity
C4F17_20955	COG0583	DNA-binding transcription factor activity
C4F17_20960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4F17_20970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4F17_20985	COG1764	response to oxidative stress
C4F17_20990	COG1846	Transcriptional regulator
C4F17_21005	COG1131	(ABC) transporter
C4F17_21030	COG0625	glutathione transferase activity
C4F17_21045	COG0640	Transcriptional regulator
C4F17_21055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4F17_21070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4F17_21075	COG3842	ATPase activity
C4F17_21080	COG4208	sulfate ABC transporter
C4F17_21090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4F17_21125	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4F17_21150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4F17_21165	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_21170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4F17_21185	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_21195	COG0411	ABC transporter
C4F17_21200	COG0410	ABC transporter
C4F17_21220	COG2095	MarC family integral membrane protein
C4F17_21225	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_21235	COG0412	Dienelactone hydrolase
C4F17_21240	COG0583	DNA-binding transcription factor activity
C4F17_21255	COG0598	Magnesium transport protein CorA
C4F17_21280	COG2945	thiolester hydrolase activity
C4F17_21285	COG1686	Belongs to the peptidase S11 family
C4F17_21290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4F17_21295	COG0049	tRNA binding
C4F17_21300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4F17_21310	COG0051	transcription antitermination factor activity, RNA binding
C4F17_21325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4F17_21330	COG0088	Forms part of the polypeptide exit tunnel
C4F17_21335	COG0089	rRNA binding
C4F17_21340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4F17_21345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4F17_21350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4F17_21355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4F17_21360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4F17_21365	COG0255	Belongs to the universal ribosomal protein uL29 family
C4F17_21370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4F17_21375	COG0678	peroxiredoxin activity
C4F17_21390	COG3909	cytochrome
C4F17_21395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4F17_21410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4F17_21415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4F17_21445	COG0745	RESPONSE REGULATOR receiver
C4F17_21455	COG2130	NADP-dependent
C4F17_21480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4F17_21500	COG2205	protein histidine kinase activity
C4F17_21505	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_21520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4F17_21525	COG0321	lipoyl(octanoyl) transferase activity
C4F17_21535	COG2921	Belongs to the UPF0250 family
C4F17_21550	COG0356	it plays a direct role in the translocation of protons across the membrane
C4F17_21560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4F17_21565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4F17_21570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4F17_21575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4F17_21585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4F17_21590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4F17_21605	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4F17_21610	COG1879	ABC-type sugar transport system periplasmic component
C4F17_21615	COG0673	inositol 2-dehydrogenase activity
C4F17_21630	COG1793	dna ligase
C4F17_21630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4F17_21635	COG1793	dna ligase
C4F17_21635	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4F17_21640	COG1201	RNA secondary structure unwinding
C4F17_21645	COG3118	belongs to the thioredoxin family
C4F17_21680	COG1177	transmembrane transport
C4F17_21685	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4F17_21690	COG3842	ATPase activity
C4F17_21695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4F17_21740	COG1309	transcriptional regulator
C4F17_21745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4F17_21750	COG0778	Nitroreductase
C4F17_21755	COG2267	carboxylic ester hydrolase activity
C4F17_21760	COG0251	oxidation-reduction process
C4F17_21765	COG1335	isochorismatase
C4F17_21770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_21795	COG1538	Outer membrane efflux protein
C4F17_21800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_21805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_21855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4F17_21860	COG0792	nuclease activity
C4F17_21865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4F17_21875	COG2084	Dehydrogenase
C4F17_21880	COG0789	Transcriptional regulator
C4F17_21915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4F17_21975	COG0714	Associated with various cellular activities
C4F17_21990	COG0010	Belongs to the arginase family
C4F17_21995	COG1505	serine-type exopeptidase activity
C4F17_22035	COG2124	cytochrome p450
C4F17_22035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4F17_22050	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_22055	COG0439	Biotin carboxylase
C4F17_22085	COG1462	curli production assembly transport component CsgG
C4F17_22125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_22165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4F17_22205	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_22210	COG3186	Phenylalanine-4-hydroxylase
C4F17_22225	COG1522	sequence-specific DNA binding
C4F17_22235	COG4535	Mg2 and Co2 transporter CorC
C4F17_22240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4F17_22250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_22315	COG0671	phosphoesterase, PA-phosphatase related
C4F17_22325	COG1597	lipid kinase activity
C4F17_22330	COG0752	glycyl-tRNA synthetase alpha subunit
C4F17_22335	COG0751	glycine-tRNA ligase activity
C4F17_22350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4F17_22385	COG0789	Transcriptional regulator
C4F17_22390	COG0288	reversible hydration of carbon dioxide
C4F17_22395	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4F17_22400	COG0183	Belongs to the thiolase family
C4F17_22410	COG1960	acyl-CoA dehydrogenase activity
C4F17_22415	COG1408	metallophosphoesterase
C4F17_22430	COG3012	SEC-C Motif Domain Protein
C4F17_22435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4F17_22440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4F17_22455	COG1960	acyl-CoA dehydrogenase activity
C4F17_22460	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_22465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4F17_22475	COG1024	Enoyl-CoA hydratase
C4F17_22500	COG0625	glutathione transferase activity
C4F17_22510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4F17_22515	COG1414	Transcriptional regulator
C4F17_22530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_22545	COG1280	lysine exporter protein (LysE YggA)
C4F17_22565	COG0477	Major facilitator Superfamily
C4F17_22575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4F17_22585	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_22595	COG2423	ornithine cyclodeaminase activity
C4F17_22615	COG2814	Major facilitator Superfamily
C4F17_22625	COG4555	ABC transporter
C4F17_22640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4F17_22660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4F17_22665	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4F17_22675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4F17_22680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4F17_22695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4F17_22700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4F17_22705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4F17_22710	COG0316	Belongs to the HesB IscA family
C4F17_22715	COG2814	Major facilitator Superfamily
C4F17_22720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4F17_22745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4F17_22750	COG1490	D-aminoacyl-tRNA deacylase activity
C4F17_22755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4F17_22760	COG1702	phosphate starvation-inducible protein PhoH
C4F17_22765	COG0632	four-way junction helicase activity
C4F17_22780	COG4589	Belongs to the CDS family
C4F17_22795	COG0671	phosphoesterase, PA-phosphatase related
C4F17_22795	COG2453	phosphatase
C4F17_22800	COG2267	carboxylic ester hydrolase activity
C4F17_22805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4F17_22810	COG2255	four-way junction helicase activity
C4F17_22830	COG1960	acyl-CoA dehydrogenase activity
C4F17_22835	COG1960	acyl-CoA dehydrogenase activity
C4F17_22840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_22845	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_22870	COG2909	trisaccharide binding
C4F17_22880	COG0183	Belongs to the thiolase family
C4F17_22885	COG0745	RESPONSE REGULATOR receiver
C4F17_22885	COG3706	GGDEF domain
C4F17_22915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4F17_22925	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_22965	COG1024	Enoyl-CoA hydratase
C4F17_22970	COG2076	Multidrug Resistance protein
C4F17_22985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4F17_22990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_23000	COG1869	D-ribose catabolic process
C4F17_23005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4F17_23010	COG1609	Transcriptional regulator
C4F17_23015	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4F17_23020	COG1129	ABC transporter
C4F17_23025	COG1879	ABC-type sugar transport system periplasmic component
C4F17_23030	COG0012	GTP binding
C4F17_23050	COG1238	metal cluster binding
C4F17_23055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4F17_23065	COG0138	bifunctional purine biosynthesis protein purh
C4F17_23075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4F17_23085	COG1773	rubredoxin
C4F17_23105	COG0840	transmembrane signaling receptor activity
C4F17_23115	COG0415	Belongs to the DNA photolyase family
C4F17_23120	COG1678	Uncharacterized ACR, COG1678
C4F17_23125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4F17_23130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4F17_23135	COG0540	Belongs to the ATCase OTCase family
C4F17_23170	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_23200	COG0697	spore germination
C4F17_23205	COG1902	pentaerythritol trinitrate reductase activity
C4F17_23225	COG0840	transmembrane signaling receptor activity
C4F17_23270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4F17_23280	COG3485	protocatechuate 3,4-dioxygenase
C4F17_23285	COG3485	protocatechuate 3,4-dioxygenase
C4F17_23290	COG0583	DNA-binding transcription factor activity
C4F17_23310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4F17_23325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_23385	COG4964	Belongs to the GSP D family
C4F17_23415	COG3063	Type IV pilus biogenesis stability protein PilW
C4F17_23435	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_23445	COG1137	ATPase activity
C4F17_23475	COG1414	Transcriptional regulator
C4F17_23485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4F17_23490	COG0183	Belongs to the thiolase family
C4F17_23525	COG1073	alpha beta
C4F17_23550	COG4650	regulator
C4F17_23565	COG1690	Belongs to the RtcB family
C4F17_23575	COG1234	tRNA 3'-trailer cleavage
C4F17_23580	COG3541	Predicted nucleotidyltransferase
C4F17_23585	COG0430	RNA-3'-phosphate cyclase activity
C4F17_23600	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4F17_23620	COG3485	protocatechuate 3,4-dioxygenase
C4F17_23630	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4F17_23660	COG1960	acyl-CoA dehydrogenase activity
C4F17_23670	COG0410	ABC transporter
C4F17_23675	COG0411	ABC transporter
C4F17_23700	COG1024	Enoyl-CoA hydratase
C4F17_23735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4F17_23745	COG2226	methyltransferase
C4F17_23755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4F17_23760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4F17_23765	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4F17_23800	COG0109	protoheme IX farnesyltransferase activity
C4F17_23805	COG1999	signal sequence binding
C4F17_23810	COG4335	DNA alkylation repair
C4F17_23815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4F17_23830	COG0784	Response regulator, receiver
C4F17_23830	COG2198	Histidine kinase
C4F17_23830	COG2205	protein histidine kinase activity
C4F17_23850	COG0612	Peptidase, M16
C4F17_23855	COG0612	Peptidase, M16
C4F17_23870	COG0742	ribosomal rna small subunit methyltransferase
C4F17_23875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4F17_23880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4F17_23885	COG1984	allophanate hydrolase subunit 2
C4F17_23890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4F17_23895	COG2267	carboxylic ester hydrolase activity
C4F17_23920	COG0583	DNA-binding transcription factor activity
C4F17_23935	COG0346	lactoylglutathione lyase activity
C4F17_23960	COG0747	negative chemotaxis
C4F17_23965	COG4608	Belongs to the ABC transporter superfamily
C4F17_23975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_23985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4F17_23995	COG0193	aminoacyl-tRNA hydrolase activity
C4F17_24000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4F17_24005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4F17_24015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4F17_24030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4F17_24035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C4F17_24045	COG1660	Displays ATPase and GTPase activities
C4F17_24050	COG0497	DNA recombination
C4F17_24055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4F17_24060	COG1420	regulation of RNA biosynthetic process
C4F17_24090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_24095	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_24105	COG0583	DNA-binding transcription factor activity
C4F17_24125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4F17_24130	COG1758	RNA polymerase activity
C4F17_24135	COG0194	GDP metabolic process
C4F17_24140	COG1561	YicC-like family, N-terminal region
C4F17_24155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4F17_24160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4F17_24165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4F17_24175	COG0582	viral genome integration into host DNA
C4F17_24430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4F17_24435	COG2814	Major facilitator Superfamily
C4F17_24475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_24500	COG2207	Transcriptional regulator
C4F17_24505	COG0300	oxidoreductase activity
C4F17_24515	COG4106	trans-aconitate 2-methyltransferase activity
C4F17_24520	COG0583	DNA-binding transcription factor activity
C4F17_24525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_24535	COG1959	2 iron, 2 sulfur cluster binding
C4F17_24550	COG1289	transmembrane transporter activity
C4F17_24565	COG0745	RESPONSE REGULATOR receiver
C4F17_24570	COG2205	protein histidine kinase activity
C4F17_24580	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4F17_24610	COG2205	protein histidine kinase activity
C4F17_24630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4F17_24630	COG2205	protein histidine kinase activity
C4F17_24635	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4F17_24645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4F17_24650	COG0830	nickel cation binding
C4F17_24655	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4F17_24660	COG0804	urea catabolic process
C4F17_24665	COG0832	Belongs to the urease beta subunit family
C4F17_24675	COG0831	urea catabolic process
C4F17_24695	COG0583	DNA-binding transcription factor activity
C4F17_24710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4F17_24725	COG0653	protein targeting
C4F17_24730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4F17_24740	COG0494	nUDIX hydrolase
C4F17_24750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4F17_24750	COG2755	lipolytic protein G-D-S-L family
C4F17_24755	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4F17_24770	COG1696	Membrane protein involved in D-alanine export
C4F17_24780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4F17_24800	COG0142	geranyltranstransferase activity
C4F17_24805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4F17_24810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4F17_24815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4F17_24820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4F17_24830	COG0494	nUDIX hydrolase
C4F17_24835	COG0442	prolyl-tRNA aminoacylation
C4F17_24845	COG1253	flavin adenine dinucleotide binding
C4F17_24860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4F17_24865	COG2890	protein-(glutamine-N5) methyltransferase activity
C4F17_24870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4F17_24875	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4F17_24890	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4F17_24895	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4F17_24905	COG1522	sequence-specific DNA binding
C4F17_24910	COG3264	Mechanosensitive ion channel
C4F17_24910	COG1511	domain protein
C4F17_24915	COG0584	glycerophosphoryl diester phosphodiesterase
C4F17_24920	COG3842	ATPase activity
C4F17_24925	COG0395	ABC-type sugar transport system, permease component
C4F17_24930	COG1175	transmembrane transport
C4F17_24935	COG1653	transport
C4F17_24940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4F17_24960	COG2226	methyltransferase
C4F17_24975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4F17_24980	COG4145	pantothenate transmembrane transporter activity
C4F17_24995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4F17_25000	COG0494	nUDIX hydrolase
C4F17_25030	COG3237	CsbD-like
C4F17_25070	COG2197	response regulator
C4F17_25080	COG2982	Protein involved in outer membrane biogenesis
C4F17_25085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4F17_25090	COG0793	Belongs to the peptidase S41A family
C4F17_25095	COG0588	phosphoglycerate mutase activity
C4F17_25100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4F17_25110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4F17_25115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4F17_25125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4F17_25135	COG0720	synthase
C4F17_25140	COG0602	queuosine metabolic process
C4F17_25145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4F17_25150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4F17_25170	COG0659	secondary active sulfate transmembrane transporter activity
C4F17_25175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4F17_25175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4F17_25185	COG0473	3-isopropylmalate dehydrogenase activity
C4F17_25190	COG3132	Protein of unknown function, DUF480
C4F17_25205	COG3548	integral membrane protein
C4F17_25210	COG1522	sequence-specific DNA binding
C4F17_25215	COG1473	amidohydrolase
C4F17_25235	COG0489	protein tyrosine kinase activity
C4F17_25240	COG0583	DNA-binding transcription factor activity
C4F17_25260	COG4149	molybdate abc transporter
C4F17_25265	COG0725	ABC transporter, periplasmic molybdate-binding protein
C4F17_25270	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4F17_25275	COG0243	molybdopterin cofactor binding
C4F17_25285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4F17_25290	COG2831	hemolysin activation secretion protein
C4F17_25300	COG3210	domain, Protein
C4F17_25305	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4F17_25310	COG3639	organic phosphonate transmembrane transporter activity
C4F17_25315	COG3639	organic phosphonate transmembrane transporter activity
C4F17_25320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4F17_25325	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C4F17_25340	COG3276	selenocysteine insertion sequence binding
C4F17_25355	COG2864	formate dehydrogenase
C4F17_25360	COG0437	4 iron, 4 sulfur cluster binding
C4F17_25365	COG3383	formate dehydrogenase (NAD+) activity
C4F17_25365	COG0243	molybdopterin cofactor binding
C4F17_25370	COG3383	formate dehydrogenase (NAD+) activity
C4F17_25370	COG0243	molybdopterin cofactor binding
C4F17_25380	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4F17_25400	COG0583	DNA-binding transcription factor activity
C4F17_25405	COG0477	Major facilitator Superfamily
C4F17_25420	COG1272	protein, Hemolysin III
C4F17_25425	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4F17_25440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C4F17_25445	COG1845	cytochrome c oxidase, subunit III
C4F17_25450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4F17_25455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4F17_25460	COG0477	Major facilitator Superfamily
C4F17_25465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4F17_25475	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
C4F17_25485	COG0765	amino acid transport
C4F17_25490	COG0765	amino acid transport
C4F17_25505	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4F17_25530	COG2003	Belongs to the UPF0758 family
C4F17_25535	COG1047	Peptidyl-prolyl cis-trans
C4F17_25540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4F17_25550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4F17_25580	COG1815	bacterial-type flagellum-dependent cell motility
C4F17_25585	COG1558	bacterial-type flagellum-dependent cell motility
C4F17_25590	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4F17_25595	COG1749	Flagellar hook protein flgE
C4F17_25605	COG4786	Flagellar basal body rod
C4F17_25620	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4F17_25620	COG3951	Flagellar rod assembly protein muramidase FlgJ
C4F17_25625	COG0835	chemotaxis
C4F17_25650	COG0840	transmembrane signaling receptor activity
C4F17_25680	COG1256	bacterial-type flagellum assembly
C4F17_25690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4F17_25700	COG1987	bacterial-type flagellum assembly
C4F17_25725	COG1580	Controls the rotational direction of flagella during chemotaxis
C4F17_25735	COG2882	bacterial-type flagellum organization
C4F17_25745	COG1317	bacterial-type flagellum organization
C4F17_25750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4F17_25755	COG1766	The M ring may be actively involved in energy transduction
C4F17_25775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4F17_25795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4F17_25825	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C4F17_25830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4F17_25835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4F17_25845	COG0745	RESPONSE REGULATOR receiver
C4F17_25850	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4F17_25860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4F17_25875	COG1191	sigma factor activity
C4F17_25880	COG3387	PFAM Glycoside hydrolase 15-related
C4F17_25885	COG3265	gluconokinase activity
C4F17_25890	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_25895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4F17_25900	COG1063	alcohol dehydrogenase
C4F17_25905	COG1609	Transcriptional regulator
C4F17_25910	COG0583	DNA-binding transcription factor activity
C4F17_25925	COG1950	PFAM Membrane protein of
C4F17_25930	COG5002	protein histidine kinase activity
C4F17_25935	COG2197	response regulator
C4F17_25940	COG0180	Tryptophanyl-tRNA synthetase
C4F17_25945	COG1994	Peptidase M50
C4F17_25950	COG0009	L-threonylcarbamoyladenylate synthase
C4F17_25960	COG0613	PHP domain protein
C4F17_25970	COG0306	phosphate transporter
C4F17_26000	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_26025	COG2814	Major facilitator Superfamily
C4F17_26030	COG3540	Alkaline phosphatase
C4F17_26035	COG0667	Aldo Keto reductase
C4F17_26050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_26060	COG5002	protein histidine kinase activity
C4F17_26070	COG2814	Major facilitator Superfamily
C4F17_26095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4F17_26115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4F17_26130	COG0604	alcohol dehydrogenase
C4F17_26150	COG1309	transcriptional regulator
C4F17_26155	COG2226	methyltransferase
C4F17_26210	COG0477	Major facilitator Superfamily
C4F17_26215	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4F17_26220	COG1414	Transcriptional regulator
C4F17_26250	COG1414	Transcriptional regulator
C4F17_26260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4F17_26265	COG0583	DNA-binding transcription factor activity
C4F17_26270	COG0243	molybdopterin cofactor binding
C4F17_26275	COG0437	4 iron, 4 sulfur cluster binding
C4F17_26280	COG3302	dmso reductase anchor subunit
C4F17_26295	COG1522	sequence-specific DNA binding
C4F17_26305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4F17_26310	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_26315	COG4154	Belongs to the RbsD FucU family
C4F17_26335	COG1129	ABC transporter
C4F17_26355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4F17_26365	COG3501	Rhs element vgr protein
C4F17_26380	COG3209	COG3209 Rhs family protein
C4F17_26410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4F17_26415	COG0308	aminopeptidase N
C4F17_26420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4F17_26430	COG1464	Belongs to the NlpA lipoprotein family
C4F17_26435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4F17_26440	COG2011	ABC-type metal ion transport system permease component
C4F17_26460	COG1464	Belongs to the NlpA lipoprotein family
C4F17_26465	COG0583	DNA-binding transcription factor activity
C4F17_26470	COG0667	Aldo Keto reductase
C4F17_26475	COG2267	carboxylic ester hydrolase activity
C4F17_26480	COG0667	Aldo Keto reductase
C4F17_26485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4F17_26490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4F17_26495	COG0251	oxidation-reduction process
C4F17_26500	COG3577	Aspartyl protease
C4F17_26505	COG1666	GTP binding
C4F17_26510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4F17_26520	COG0137	argininosuccinate synthase activity
C4F17_26525	COG3123	guanosine phosphorylase activity
C4F17_26535	COG1393	Belongs to the ArsC family
C4F17_26540	COG0285	dihydrofolate synthase activity
C4F17_26565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4F17_26585	COG0776	regulation of translation
C4F17_26610	COG4797	methyltransferase
C4F17_26610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4F17_26620	COG1187	pseudouridine synthase activity
C4F17_26645	COG1058	Belongs to the CinA family
C4F17_26645	COG1546	Belongs to the CinA family
C4F17_26660	COG3852	Histidine kinase
C4F17_26675	COG0708	Exodeoxyribonuclease III
C4F17_27055	COG4948	Mandelate Racemase Muconate Lactonizing
C4F17_27060	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_27070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4F17_27075	COG0583	DNA-binding transcription factor activity
C4F17_27080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4F17_27095	COG0511	ligase activity, forming carbon-carbon bonds
C4F17_27100	COG0439	Biotin carboxylase
C4F17_27105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4F17_27110	COG1984	allophanate hydrolase subunit 2
C4F17_27120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4F17_27125	COG4221	oxidoreductase activity
C4F17_27130	COG0765	amino acid transport
C4F17_27135	COG0765	amino acid transport
C4F17_27145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4F17_27155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4F17_27160	COG0745	RESPONSE REGULATOR receiver
C4F17_27175	COG2205	protein histidine kinase activity
C4F17_27180	COG0745	RESPONSE REGULATOR receiver
C4F17_27185	COG2197	response regulator
C4F17_27240	COG1301	dicarboxylic acid transport
C4F17_27250	COG1301	dicarboxylic acid transport
C4F17_27275	COG3501	Rhs element vgr protein
C4F17_27335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4F17_27340	COG0277	FAD linked oxidase domain protein
C4F17_27355	COG1295	ribonuclease BN
C4F17_27365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4F17_27375	COG0583	DNA-binding transcription factor activity
C4F17_27385	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_27395	COG2267	carboxylic ester hydrolase activity
C4F17_27410	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_27415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4F17_27420	COG0583	DNA-binding transcription factor activity
C4F17_27480	COG1522	sequence-specific DNA binding
C4F17_27490	COG1538	Outer membrane efflux protein
C4F17_27520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4F17_27530	COG0431	NADPH-dependent FMN reductase
C4F17_27540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4F17_27560	COG3070	regulator of competence-specific genes
C4F17_27565	COG0346	lactoylglutathione lyase activity
C4F17_27575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4F17_27580	COG0596	Alpha beta hydrolase
C4F17_27590	COG0625	glutathione transferase activity
C4F17_27610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4F17_27615	COG2719	SpoVR family
C4F17_27620	COG2718	Belongs to the UPF0229 family
C4F17_27630	COG2271	Major facilitator Superfamily
C4F17_27700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4F17_27715	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4F17_27735	COG2366	antibiotic biosynthetic process
C4F17_27755	COG0840	transmembrane signaling receptor activity
C4F17_27765	COG2197	response regulator
C4F17_27770	COG2205	protein histidine kinase activity
C4F17_27800	COG0066	3-isopropylmalate dehydratase activity
C4F17_27805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4F17_27815	COG0410	ABC transporter
C4F17_27835	COG0683	leucine binding
C4F17_27840	COG2188	Transcriptional regulator
C4F17_27845	COG3391	amine dehydrogenase activity
C4F17_27860	COG1301	dicarboxylic acid transport
C4F17_27895	COG0384	phenazine biosynthesis protein PhzF
C4F17_27900	COG0077	Prephenate dehydratase
C4F17_27900	COG1605	Chorismate mutase
C4F17_27925	COG2003	Belongs to the UPF0758 family
C4F17_27935	COG1396	sequence-specific DNA binding
C4F17_27955	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_27965	COG0583	DNA-binding transcription factor activity
C4F17_27970	COG1960	acyl-CoA dehydrogenase activity
C4F17_27980	COG0596	Alpha beta hydrolase
C4F17_28025	COG2309	aminopeptidase activity
C4F17_28030	COG1335	isochorismatase
C4F17_28040	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_28050	COG0411	ABC transporter
C4F17_28055	COG3842	ATPase activity
C4F17_28065	COG0583	DNA-binding transcription factor activity
C4F17_28075	COG1737	Transcriptional regulator
C4F17_28075	COG0837	glucose binding
C4F17_28090	COG1024	Enoyl-CoA hydratase
C4F17_28100	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_28105	COG0183	Belongs to the thiolase family
C4F17_28125	COG2207	Transcriptional regulator
C4F17_28130	COG1289	transmembrane transporter activity
C4F17_28140	COG1566	PFAM secretion protein HlyD family protein
C4F17_28150	COG0583	DNA-binding transcription factor activity
C4F17_28165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_28180	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_28190	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_28200	COG0411	ABC transporter
C4F17_28210	COG3246	L-lysine catabolic process to acetate
C4F17_28215	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_28220	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4F17_28225	COG2272	Belongs to the type-B carboxylesterase lipase family
C4F17_28245	COG1609	Transcriptional regulator
C4F17_28250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_28255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4F17_28265	COG1850	ribulose-bisphosphate carboxylase activity
C4F17_28290	COG2205	protein histidine kinase activity
C4F17_28320	COG1538	Outer membrane efflux protein
C4F17_28325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_28330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_28410	COG0402	S-adenosylhomocysteine deaminase activity
C4F17_28420	COG0583	DNA-binding transcription factor activity
C4F17_28430	COG2814	Major facilitator Superfamily
C4F17_28470	COG1902	pentaerythritol trinitrate reductase activity
C4F17_28475	COG2080	2 iron, 2 sulfur cluster binding
C4F17_28480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4F17_28480	COG2010	Cytochrome c
C4F17_28490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_28500	COG0583	DNA-binding transcription factor activity
C4F17_28515	COG0604	alcohol dehydrogenase
C4F17_28515	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_28515	COG3321	synthase
C4F17_28540	COG1522	sequence-specific DNA binding
C4F17_28545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4F17_28550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4F17_28565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_28570	COG4166	transmembrane transport
C4F17_28575	COG0601	transmembrane transport
C4F17_28580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_28590	COG0473	3-isopropylmalate dehydrogenase activity
C4F17_28595	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_28610	COG2079	MmgE PrpD family protein
C4F17_28615	COG1042	CoA-binding domain protein
C4F17_28615	COG0045	succinate-CoA ligase (ADP-forming) activity
C4F17_28615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4F17_28620	COG1024	Enoyl-CoA hydratase
C4F17_28640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4F17_28650	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_28650	COG2030	dehydratase
C4F17_28655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_28660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4F17_28665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4F17_28675	COG1024	Enoyl-CoA hydratase
C4F17_28695	COG1414	Transcriptional regulator
C4F17_28700	COG1960	acyl-CoA dehydrogenase activity
C4F17_28705	COG1042	CoA-binding domain protein
C4F17_28705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4F17_28705	COG0045	succinate-CoA ligase (ADP-forming) activity
C4F17_28730	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_28745	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_28760	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_28785	COG0583	DNA-binding transcription factor activity
C4F17_28820	COG3237	CsbD-like
C4F17_28835	COG0443	Heat shock 70 kDa protein
C4F17_28870	COG0514	ATP-dependent DNA helicase (RecQ)
C4F17_28885	COG0583	DNA-binding transcription factor activity
C4F17_28925	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_28950	COG0243	molybdopterin cofactor binding
C4F17_28960	COG2080	2 iron, 2 sulfur cluster binding
C4F17_28965	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4F17_28970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4F17_29005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4F17_29020	COG4171	peptide transport system, permease
C4F17_29025	COG0601	transmembrane transport
C4F17_29055	COG1116	anion transmembrane transporter activity
C4F17_29065	COG1605	Chorismate mutase
C4F17_29070	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_29090	COG1192	Involved in chromosome partitioning
C4F17_29125	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_29140	COG0625	glutathione transferase activity
C4F17_29150	COG0028	Belongs to the TPP enzyme family
C4F17_29175	COG2267	carboxylic ester hydrolase activity
C4F17_29185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_29230	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_29255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4F17_29265	COG2205	protein histidine kinase activity
C4F17_29270	COG0745	RESPONSE REGULATOR receiver
C4F17_29295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_29300	COG1136	(ABC) transporter
C4F17_29300	COG0577	efflux transmembrane transporter activity
C4F17_29315	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4F17_29325	COG1686	Belongs to the peptidase S11 family
C4F17_29365	COG1012	belongs to the aldehyde dehydrogenase family
C4F17_29380	COG1840	ABC-type Fe3 transport system, periplasmic component
C4F17_29385	COG3842	ATPase activity
C4F17_29400	COG0417	DNA replication proofreading
C4F17_29405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4F17_29410	COG0768	penicillin binding
C4F17_29415	COG2814	Major facilitator Superfamily
C4F17_29420	COG1733	regulation of RNA biosynthetic process
C4F17_29440	COG3829	transcription factor binding
C4F17_29450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_29460	COG0431	NADPH-dependent FMN reductase
C4F17_29475	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_29480	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4F17_29495	COG0410	ABC transporter
C4F17_29505	COG3046	protein related to deoxyribodipyrimidine photolyase
C4F17_29515	COG2814	Major facilitator Superfamily
C4F17_29545	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_29580	COG1024	Enoyl-CoA hydratase
C4F17_29600	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C4F17_29625	COG0411	ABC transporter
C4F17_29635	COG0277	FAD linked oxidase domain protein
C4F17_29640	COG1522	sequence-specific DNA binding
C4F17_29655	COG0251	oxidation-reduction process
C4F17_29660	COG0477	Major facilitator Superfamily
C4F17_29700	COG2826	transposase and inactivated derivatives, IS30 family
C4F17_29715	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_29765	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_29780	COG0745	RESPONSE REGULATOR receiver
C4F17_29785	COG2205	protein histidine kinase activity
C4F17_29790	COG1764	response to oxidative stress
C4F17_29800	COG2133	pyrroloquinoline quinone binding
C4F17_29815	COG0791	NLP P60 protein
C4F17_29830	COG1966	Carbon starvation protein
C4F17_29835	COG2879	small protein
C4F17_29855	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_29860	COG1960	acyl-CoA dehydrogenase activity
C4F17_29875	COG3040	lipid binding
C4F17_29900	COG0583	DNA-binding transcription factor activity
C4F17_29915	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4F17_29925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4F17_29955	COG2813	Specifically methylates the guanine in position
C4F17_29985	COG0829	nickel cation binding
C4F17_29990	COG0590	tRNA wobble adenosine to inosine editing
C4F17_29995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_30005	COG5001	Diguanylate cyclase
C4F17_30005	COG3300	MHYT domain
C4F17_30010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_30030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4F17_30035	COG1733	regulation of RNA biosynthetic process
C4F17_30065	COG0745	RESPONSE REGULATOR receiver
C4F17_30070	COG0642	Histidine kinase
C4F17_30080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_30085	COG1116	anion transmembrane transporter activity
C4F17_30095	COG0280	phosphate acetyltransferase
C4F17_30095	COG0281	malic enzyme
C4F17_30105	COG2084	Dehydrogenase
C4F17_30110	COG3622	Belongs to the hyi family
C4F17_30115	COG3960	tartronate-semialdehyde synthase activity
C4F17_30120	COG0583	DNA-binding transcription factor activity
C4F17_30135	COG0628	permease
C4F17_30145	COG1301	dicarboxylic acid transport
C4F17_30160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4F17_30175	COG2186	Transcriptional regulator
C4F17_30180	COG2351	hydroxyisourate hydrolase activity
C4F17_30215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4F17_30235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4F17_30295	COG0730	response to heat
C4F17_30305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4F17_30315	COG2252	PERMEase
C4F17_30340	COG0515	serine threonine protein kinase
C4F17_30355	COG1944	ATP diphosphatase activity
C4F17_30385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4F17_30390	COG1126	abc transporter atp-binding protein
C4F17_30410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4F17_30415	COG2814	Major facilitator Superfamily
C4F17_30420	COG0583	DNA-binding transcription factor activity
C4F17_30425	COG4977	sequence-specific DNA binding
C4F17_30435	COG0154	amidase activity
C4F17_30480	COG0477	Major facilitator Superfamily
C4F17_30490	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4F17_30490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4F17_30505	COG3265	gluconokinase activity
C4F17_30515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4F17_30520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_30525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4F17_30550	COG0583	DNA-binding transcription factor activity
C4F17_30570	COG4566	intracellular signal transduction
C4F17_30590	COG0583	DNA-binding transcription factor activity
C4F17_30595	COG2814	Major facilitator Superfamily
C4F17_30645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_30655	COG2186	Transcriptional regulator
C4F17_30680	COG2186	Transcriptional regulator
C4F17_30685	COG1960	acyl-CoA dehydrogenase activity
C4F17_30690	COG2186	Transcriptional regulator
C4F17_30695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4F17_30700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4F17_30725	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_30730	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_30735	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_30750	COG1024	Enoyl-CoA hydratase
C4F17_30755	COG2030	dehydratase
C4F17_30760	COG0604	alcohol dehydrogenase
C4F17_30760	COG3321	synthase
C4F17_30790	COG1960	acyl-CoA dehydrogenase activity
C4F17_30795	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_30810	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_30825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_30830	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_30840	COG1024	Enoyl-CoA hydratase
C4F17_30850	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4F17_30850	COG1024	Enoyl-CoA hydratase
C4F17_30855	COG0183	Belongs to the thiolase family
C4F17_30860	COG0604	alcohol dehydrogenase
C4F17_30860	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_30860	COG3321	synthase
C4F17_30895	COG1024	Enoyl-CoA hydratase
C4F17_30900	COG1960	acyl-CoA dehydrogenase activity
C4F17_30905	COG1960	acyl-CoA dehydrogenase activity
C4F17_30910	COG0402	S-adenosylhomocysteine deaminase activity
C4F17_30920	COG0717	Belongs to the dCTP deaminase family
C4F17_30925	COG2321	neutral zinc metallopeptidase
C4F17_30930	COG0513	Belongs to the DEAD box helicase family
C4F17_30950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_30955	COG1960	acyl-CoA dehydrogenase activity
C4F17_30965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_30975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4F17_31000	COG2207	Transcriptional regulator
C4F17_31015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4F17_31020	COG1253	flavin adenine dinucleotide binding
C4F17_31030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4F17_31035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4F17_31040	COG5002	protein histidine kinase activity
C4F17_31040	COG3447	MASE1 domain protein
C4F17_31040	COG5001	Diguanylate cyclase
C4F17_31060	COG0583	DNA-binding transcription factor activity
C4F17_31090	COG1228	amidohydrolase
C4F17_31095	COG4608	Belongs to the ABC transporter superfamily
C4F17_31100	COG0444	Belongs to the ABC transporter superfamily
C4F17_31105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4F17_31110	COG0601	transmembrane transport
C4F17_31130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_31135	COG4521	taurine ABC transporter
C4F17_31145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_31150	COG0583	DNA-binding transcription factor activity
C4F17_31155	COG0583	DNA-binding transcription factor activity
C4F17_31160	COG0596	Alpha beta hydrolase
C4F17_31165	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_31175	COG5002	protein histidine kinase activity
C4F17_31185	COG0745	RESPONSE REGULATOR receiver
C4F17_31195	COG5295	Hep Hag repeat protein
C4F17_31225	COG0288	reversible hydration of carbon dioxide
C4F17_31235	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_31240	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_31250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4F17_31265	COG0583	DNA-binding transcription factor activity
C4F17_31270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4F17_31280	COG1960	acyl-CoA dehydrogenase activity
C4F17_31290	COG1024	Enoyl-CoA hydratase
C4F17_31295	COG0045	succinate-CoA ligase (ADP-forming) activity
C4F17_31295	COG1042	CoA-binding domain protein
C4F17_31295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4F17_31310	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4F17_31315	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_31320	COG3181	Tripartite tricarboxylate transporter family receptor
C4F17_31335	COG0596	Alpha beta hydrolase
C4F17_31345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4F17_31555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4F17_31560	COG1126	abc transporter atp-binding protein
C4F17_31575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4F17_31610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4F17_31620	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4F17_31630	COG0411	ABC transporter
C4F17_31650	COG0583	DNA-binding transcription factor activity
C4F17_31665	COG2267	carboxylic ester hydrolase activity
C4F17_31675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_31680	COG0318	PFAM AMP-dependent synthetase and ligase
C4F17_31690	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_31705	COG0583	DNA-binding transcription factor activity
C4F17_31730	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4F17_31745	COG4251	negative regulation of phosphorylation
C4F17_31745	COG2203	Gaf domain
C4F17_31745	COG3706	GGDEF domain
C4F17_31745	COG5001	Diguanylate cyclase
C4F17_31750	COG1414	Transcriptional regulator
C4F17_31770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4F17_31775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4F17_31795	COG3386	PFAM SMP-30 Gluconolaconase
C4F17_31815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4F17_31820	COG1538	Outer membrane efflux protein
C4F17_31830	COG2205	protein histidine kinase activity
C4F17_31835	COG0745	RESPONSE REGULATOR receiver
C4F17_31860	COG0747	negative chemotaxis
C4F17_31875	COG0601	transmembrane transport
C4F17_31880	COG2072	flavoprotein involved in K transport
C4F17_31905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4F17_31915	COG0842	Transport permease protein
C4F17_31920	COG1129	ABC transporter
C4F17_31920	COG0842	Transport permease protein
C4F17_31925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4F17_31950	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C4F17_31985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4F17_32035	COG0071	Belongs to the small heat shock protein (HSP20) family
C4F17_32050	COG3162	membrane
C4F17_32075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4F17_32095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4F17_32110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4F17_32135	COG0589	response to stress
C4F17_32155	COG3038	cytochrome b561
C4F17_32175	COG1063	alcohol dehydrogenase
C4F17_32205	COG0640	Transcriptional regulator
C4F17_32235	COG2823	Periplasmic or secreted lipoprotein
C4F17_32240	COG2201	protein-glutamate methylesterase activity
C4F17_32255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C4F17_32275	COG4191	Histidine kinase
C4F17_32275	COG0784	Response regulator, receiver
C4F17_32280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4F17_32285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4F17_32295	COG1028	Short-chain dehydrogenase reductase Sdr
C4F17_32310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4F17_32320	COG4716	Myosin-crossreactive antigen
C4F17_32360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4F17_32395	COG3278	Belongs to the heme-copper respiratory oxidase family
C4F17_32405	COG2217	Heavy metal translocating P-type atpase
C4F17_32430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4F17_32435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4F17_32440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4F17_32445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_32455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4F17_32470	COG1366	Belongs to the anti-sigma-factor antagonist family
C4F17_32475	COG1366	Belongs to the anti-sigma-factor antagonist family
C4F17_32480	COG2172	sigma factor antagonist activity
C4F17_32490	COG0784	Response regulator, receiver
C4F17_32490	COG2205	protein histidine kinase activity
C4F17_32495	COG5002	protein histidine kinase activity
C4F17_32495	COG2198	Histidine kinase
C4F17_32495	COG0784	Response regulator, receiver
C4F17_32500	COG0028	Belongs to the TPP enzyme family
C4F17_32525	COG2205	protein histidine kinase activity
C4F17_32530	COG0745	RESPONSE REGULATOR receiver
C4F17_32545	COG1201	RNA secondary structure unwinding
C4F17_32550	COG1285	pathogenesis
C4F17_32560	COG0583	DNA-binding transcription factor activity
C4F17_32565	COG4804	nuclease activity
C4F17_32590	COG3706	GGDEF domain
C4F17_32600	COG0028	Belongs to the TPP enzyme family
C4F17_32610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4F17_32625	COG0583	DNA-binding transcription factor activity
C4F17_32640	COG1012	belongs to the aldehyde dehydrogenase family