locus-tag class description RA8CHR_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) RA8CHR_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) RA8CHR_00003 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA8CHR_00006 ENOG4107RN3 metallophosphoesterase RA8CHR_00009 ENOG41061N2 exported protein RA8CHR_00012 ENOG4107UXM Membrane RA8CHR_00013 ENOG4105DZQ phospholipase D Transphosphatidylase RA8CHR_00014 ENOG4105X23 Endonuclease Exonuclease phosphatase RA8CHR_00018 ENOG4105EUB pirin domain protein RA8CHR_00021 ENOG4105F38 ABC transporter, permease RA8CHR_00023 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) RA8CHR_00024 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase RA8CHR_00028 ENOG4105CT7 inner membrane cred family protein RA8CHR_00029 ENOG4108JQC penicillin-binding protein 1A RA8CHR_00030 ENOG4105EB3 Histidine kinase RA8CHR_00031 ENOG4105E3W Two component transcriptional regulator (Winged helix family RA8CHR_00034 ENOG410681U heavy metal transport detoxification protein RA8CHR_00036 ENOG4105ECM Sensor protein basS pmrB RA8CHR_00037 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase RA8CHR_00038 ENOG4105CBP Major Facilitator RA8CHR_00039 ENOG4108K3A Glutathione S-transferase RA8CHR_00042 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) RA8CHR_00043 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) RA8CHR_00045 ENOG4107QJE Chromosome Partitioning Protein RA8CHR_00047 ENOG4105FA0 parb-like partition protein RA8CHR_00049 ENOG4105CQB FAD linked oxidase domain protein RA8CHR_00050 ENOG4108WBT adenosyltransferase RA8CHR_00058 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) RA8CHR_00059 ENOG4107QMS site-determining protein RA8CHR_00060 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) RA8CHR_00062 ENOG4105C2W permease RA8CHR_00063 ENOG4105KA0 thioesterase Superfamily protein RA8CHR_00066 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) RA8CHR_00067 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_00074 ENOG4105IKQ hydratase RA8CHR_00075 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_00076 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_00079 ENOG41069M3 Transcriptional regulator RA8CHR_00082 ENOG4105CKT filamentous hemagglutinin RA8CHR_00087 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme RA8CHR_00092 ENOG4105EVZ LysR family transcriptional regulator RA8CHR_00094 ENOG4105F8J Adenylate Guanylate cyclase RA8CHR_00096 ENOG4108Z9W Outer membrane porin RA8CHR_00098 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein RA8CHR_00101 ENOG4105E2B Taurine dioxygenase RA8CHR_00103 ENOG4105C2W permease RA8CHR_00108 ENOG4105C3M thioredoxin reductase RA8CHR_00109 ENOG4106H3A restriction RA8CHR_00112 ENOG4108IV0 ABC, transporter RA8CHR_00113 ENOG4105C0Z ABC transporter RA8CHR_00115 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_00117 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) RA8CHR_00121 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) RA8CHR_00132 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA8CHR_00133 ENOG4105BZU Histidine kinase RA8CHR_00138 ENOG4105DTD Dehydrogenase RA8CHR_00142 ENOG4105DPZ Two component transcriptional regulator (Winged helix family RA8CHR_00145 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) RA8CHR_00155 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) RA8CHR_00156 ENOG4105F38 ABC transporter, permease RA8CHR_00157 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component RA8CHR_00160 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) RA8CHR_00162 ENOG4107RUE extracellular solute-binding protein family 1 RA8CHR_00165 ENOG4105CI2 imidazolone-5-propionate hydrolase RA8CHR_00168 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_00170 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) RA8CHR_00175 ENOG4107QZ7 Cellulose synthase catalytic subunit RA8CHR_00176 ENOG4107EEX Cellulose synthase regulator protein RA8CHR_00177 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) RA8CHR_00178 ENOG4105EJG cellulose synthase RA8CHR_00179 ENOG4105K4H Nlp p60 protein RA8CHR_00184 ENOG4105JSC dimethylmenaquinone methyltransferase RA8CHR_00186 ENOG4108KSA LysR family transcriptional regulator RA8CHR_00187 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family RA8CHR_00189 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_00191 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_00195 ENOG4105DQE DNA ligase RA8CHR_00197 ENOG4105FDF Could be involved in DNA repair (By similarity) RA8CHR_00212 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) RA8CHR_00214 ENOG4107RZC phospholipase d RA8CHR_00215 ENOG4105EYW Ion transport protein RA8CHR_00216 ENOG4105D78 K07001 NTE family protein RA8CHR_00218 ENOG4105KWG Pfam:DUF1696 RA8CHR_00219 ENOG4105GAK amidohydrolase 2 RA8CHR_00222 ENOG4105CMM transposase RA8CHR_00225 ENOG4105DC7 peptidase M24 RA8CHR_00231 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase RA8CHR_00232 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) RA8CHR_00234 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) RA8CHR_00239 ENOG4105E2V Glycosyltransferase 36 RA8CHR_00245 ENOG4105ECQ AraC Family Transcriptional Regulator RA8CHR_00246 ENOG4105EMU Dehydrogenase RA8CHR_00248 ENOG4107R11 Transcriptional regulator RA8CHR_00251 ENOG4107RSM transcriptional regulator RA8CHR_00252 ENOG4108Z4U Ferredoxin RA8CHR_00256 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_00260 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) RA8CHR_00263 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) RA8CHR_00264 ENOG41086DT Membrane protein of unknown function RA8CHR_00269 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) RA8CHR_00270 ENOG4105D3R alkyl hydroperoxide reductase RA8CHR_00272 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_00273 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_00274 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_00278 ENOG4105EMU Dehydrogenase RA8CHR_00286 ENOG4105ETE Transcriptional regulator (LacI family RA8CHR_00287 ENOG4105D9P serine threonine protein kinase RA8CHR_00291 ENOG4106NZI LysR family Transcriptional regulator RA8CHR_00292 ENOG4105CSV Glutaminase RA8CHR_00295 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) RA8CHR_00298 ENOG4105FDP GntR family transcriptional regulator RA8CHR_00301 ENOG4105DGI Alkaline phosphatase RA8CHR_00305 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) RA8CHR_00307 ENOG4105C7B Threonine dehydratase RA8CHR_00308 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) RA8CHR_00311 ENOG4105C9U ATP-dependent DNA helicase RecQ RA8CHR_00316 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component RA8CHR_00318 ENOG4105CZE histidine utilization repressor RA8CHR_00319 ENOG4105C84 Histidine ammonia-lyase RA8CHR_00319 ENOG4105C84 Histidine ammonia-lyase RA8CHR_00320 ENOG4105CGP Urocanate hydratase RA8CHR_00324 ENOG41090B9 response to stress RA8CHR_00325 ENOG4105CI2 imidazolone-5-propionate hydrolase RA8CHR_00331 ENOG4105C3R Methionine synthase RA8CHR_00333 ENOG4105F52 Transcriptional regulator RA8CHR_00335 ENOG4105C3R Methionine synthase RA8CHR_00336 ENOG41063ZV RA8CHR_00337 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 RA8CHR_00339 ENOG4105IDI abc transporter atp-binding protein RA8CHR_00341 ENOG4108W9H Tetr family transcriptional regulator RA8CHR_00342 ENOG4105DP0 ferredoxin-NADP reductase RA8CHR_00351 ENOG4105C0Z ABC transporter RA8CHR_00352 ENOG4108IV0 ABC, transporter RA8CHR_00353 ENOG4108RWI nicotinamidase RA8CHR_00354 ENOG4108XHQ (2Fe-2S)-binding domain protein RA8CHR_00355 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding RA8CHR_00361 ENOG4105C0P Mg chelatase subunit ChlI RA8CHR_00363 ENOG4108YZA Nitrogen regulatory protein pii RA8CHR_00364 ENOG4105BZU Histidine kinase RA8CHR_00366 ENOG4105EU8 FAD linked oxidase domain protein RA8CHR_00367 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) RA8CHR_00370 ENOG4108V06 Glutathione peroxidase RA8CHR_00373 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) RA8CHR_00375 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) RA8CHR_00376 ENOG4105MP9 class II Aldolase RA8CHR_00378 ENOG4105C01 Dihydroxy-acid dehydratase RA8CHR_00382 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase RA8CHR_00383 ENOG4105C26 Dehydrogenase RA8CHR_00387 ENOG4108V8F Transcriptional regulator, MarR family RA8CHR_00388 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) RA8CHR_00390 ENOG4105DH7 May be involved in recombination (By similarity) RA8CHR_00391 ENOG4105CM2 brancheD-chain amino acid aminotransferase RA8CHR_00396 ENOG4105E0F Histidine kinase RA8CHR_00397 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_00398 ENOG4105D5U fad dependent oxidoreductase RA8CHR_00400 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) RA8CHR_00403 ENOG4105EYM Major Facilitator superfamily RA8CHR_00404 ENOG4105D0M Protease HtpX homolog RA8CHR_00405 ENOG4105EMU Dehydrogenase RA8CHR_00406 ENOG4105EQ1 Transcriptional regulator RA8CHR_00407 ENOG4105CHJ isochorismatase hydrolase RA8CHR_00409 ENOG4105EFZ amidohydrolase RA8CHR_00413 ENOG4105GVF (ABC) transporter RA8CHR_00414 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component RA8CHR_00422 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) RA8CHR_00423 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) RA8CHR_00424 ENOG4108JQ9 ABC transporter RA8CHR_00425 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) RA8CHR_00428 ENOG41061H0 Monooxygenase RA8CHR_00429 ENOG4105F04 LysR family Transcriptional regulator RA8CHR_00430 ENOG4105CGK Exodeoxyribonuclease III RA8CHR_00431 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) RA8CHR_00433 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_00434 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_00435 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_00439 ENOG4105CJN penicillin-binding protein RA8CHR_00442 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) RA8CHR_00446 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein RA8CHR_00447 ENOG4105CYX Short-chain dehydrogenase reductase Sdr RA8CHR_00451 ENOG4105CR8 Transcriptional regulator RA8CHR_00453 ENOG4105D7N magnesium and cobalt transport protein CorA RA8CHR_00454 ENOG4105D52 delta-aminolevulinic acid dehydratase RA8CHR_00455 ENOG4108YXA Membrane RA8CHR_00457 ENOG4105NZG Ferredoxin RA8CHR_00458 ENOG4105DHZ alpha beta RA8CHR_00459 ENOG4105DZ1 carboxypeptidase RA8CHR_00460 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) RA8CHR_00461 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) RA8CHR_00462 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) RA8CHR_00463 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) RA8CHR_00464 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) RA8CHR_00467 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) RA8CHR_00468 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) RA8CHR_00469 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) RA8CHR_00470 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity RA8CHR_00471 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) RA8CHR_00472 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) RA8CHR_00473 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) RA8CHR_00474 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) RA8CHR_00475 ENOG41084PQ 50s ribosomal protein l29 RA8CHR_00476 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RA8CHR_00480 ENOG4105T86 cytochrome C RA8CHR_00481 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen RA8CHR_00483 ENOG4105JHE Major Facilitator Superfamily RA8CHR_00485 ENOG41080Z8 PHOSPHOCARRIER protein RA8CHR_00486 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) RA8CHR_00489 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_00491 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein RA8CHR_00495 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase RA8CHR_00497 ENOG4105C9Q fumarate hydratase class II RA8CHR_00498 ENOG4105F4P )-transporter RA8CHR_00499 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_00500 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) RA8CHR_00501 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) RA8CHR_00502 ENOG4105F0I Aminotransferase RA8CHR_00504 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) RA8CHR_00505 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) RA8CHR_00506 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) RA8CHR_00507 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) RA8CHR_00508 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) RA8CHR_00509 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) RA8CHR_00510 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) RA8CHR_00511 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) RA8CHR_00513 ENOG4105C2J ABC transporter RA8CHR_00514 ENOG4105CNN ABC, transporter RA8CHR_00515 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator RA8CHR_00516 ENOG4105CIB oxidoreductase Domain protein RA8CHR_00525 ENOG4107T0X DNA ligase RA8CHR_00526 ENOG4107T0X DNA ligase RA8CHR_00527 ENOG4107QRT dEAD DEAH box helicase RA8CHR_00538 ENOG4105ENJ RND efflux system, outer membrane lipoprotein RA8CHR_00539 ENOG4105BZS acriflavin resistance protein RA8CHR_00541 ENOG4105C1P efflux transporter, rnd family, mfp subunit RA8CHR_00542 ENOG4108IG5 Transcriptional regulator RA8CHR_00553 ENOG4105D85 methylase RA8CHR_00573 ENOG4105C4R Atp-dependent dna helicase RA8CHR_00574 ENOG4105C9U ATP-dependent DNA helicase RecQ RA8CHR_00585 ENOG4105CA9 Pyruvate kinase RA8CHR_00587 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8CHR_00588 ENOG41079KZ Major Facilitator Superfamily RA8CHR_00596 ENOG4105ECQ AraC Family Transcriptional Regulator RA8CHR_00597 ENOG4105CSH Transporter RA8CHR_00599 ENOG4108Z4U Ferredoxin RA8CHR_00601 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase RA8CHR_00604 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein RA8CHR_00605 ENOG4105FGE Short-chain dehydrogenase reductase Sdr RA8CHR_00607 ENOG4105C26 Dehydrogenase RA8CHR_00608 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator RA8CHR_00609 ENOG4105DFW ABC transporter RA8CHR_00611 ENOG4108HWW ABC transporter RA8CHR_00612 ENOG4105C2J ABC transporter RA8CHR_00613 ENOG4107R9N ABC transporter RA8CHR_00614 ENOG41062B0 ABC transporter, permease RA8CHR_00619 ENOG41082RQ UPF0102 protein RA8CHR_00620 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) RA8CHR_00622 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8CHR_00623 ENOG4105CZX twitching motility protein RA8CHR_00624 ENOG4105CZX twitching motility protein RA8CHR_00625 ENOG4105DFA alanine racemase domain protein RA8CHR_00626 ENOG4105EW9 transcriptional regulator AsnC family RA8CHR_00627 ENOG4105C26 Dehydrogenase RA8CHR_00628 ENOG4105D82 Glutamate dehydrogenase RA8CHR_00635 ENOG4105S7S phosphonate abc transporter RA8CHR_00636 ENOG4105D5T phosphonate abc transporter RA8CHR_00637 ENOG4105EHI Phosphonate ABC transporter, periplasmic RA8CHR_00638 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process RA8CHR_00640 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) RA8CHR_00648 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) RA8CHR_00651 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_00652 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase RA8CHR_00655 ENOG41067MG lrgb family RA8CHR_00656 ENOG4105VAW lrga family RA8CHR_00657 ENOG4105CQB FAD linked oxidase domain protein RA8CHR_00659 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) RA8CHR_00666 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase RA8CHR_00676 ENOG4105CH2 amidohydrolase RA8CHR_00679 ENOG4105MWK D-amino acid dehydrogenase, small subunit RA8CHR_00684 ENOG4105MH5 phosphoesterase PA-phosphatase related protein RA8CHR_00690 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) RA8CHR_00691 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) RA8CHR_00692 ENOG4105CB5 ATP-dependent DNA helicase recG RA8CHR_00693 ENOG4105C5Q Transcriptional regulator RA8CHR_00695 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) RA8CHR_00696 ENOG4105II7 pyrroline-5-carboxylate reductase RA8CHR_00697 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) RA8CHR_00698 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) RA8CHR_00699 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits RA8CHR_00700 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) RA8CHR_00701 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) RA8CHR_00702 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) RA8CHR_00703 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) RA8CHR_00704 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) RA8CHR_00705 ENOG4105VPB 50S ribosomal protein L30 RA8CHR_00706 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) RA8CHR_00707 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) RA8CHR_00708 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) RA8CHR_00709 ENOG41067V7 50S ribosomal protein L36 RA8CHR_00710 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits RA8CHR_00711 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) RA8CHR_00712 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) RA8CHR_00713 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) RA8CHR_00714 ENOG4108ZT0 50S ribosomal protein l17 RA8CHR_00718 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_00719 ENOG4108UKI Enoyl-CoA hydratase RA8CHR_00722 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase RA8CHR_00727 ENOG4105EJC lysr family transcriptional regulator RA8CHR_00728 ENOG4105F6U Short-chain dehydrogenase reductase Sdr RA8CHR_00730 ENOG4105CPP Dehydrogenase, E1 component RA8CHR_00731 ENOG4107RUY (E1 component), alpha subunit RA8CHR_00741 ENOG4105DFW ABC transporter RA8CHR_00742 ENOG4108HWW ABC transporter RA8CHR_00746 ENOG4107TTD cytosine deaminase RA8CHR_00747 ENOG4108Z0Z intracellular protease Pfpi family RA8CHR_00748 ENOG4105DZS Phenylacetate-CoA ligase RA8CHR_00749 ENOG4108IV0 ABC, transporter RA8CHR_00753 ENOG4105C0Z ABC transporter RA8CHR_00754 ENOG4108IQE Amp-dependent synthetase and ligase RA8CHR_00755 ENOG4105IJJ transcriptional regulator, crp fnr family RA8CHR_00757 ENOG410904N short-chain dehydrogenase reductase RA8CHR_00763 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) RA8CHR_00764 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) RA8CHR_00765 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) RA8CHR_00766 ENOG4105C08 Histidine kinase RA8CHR_00767 ENOG4105EEX Two component transcriptional regulator (Winged helix family RA8CHR_00769 ENOG4105FE9 pseudouridine synthase RA8CHR_00770 ENOG4105XJC Two component transcriptional regulator (Winged helix family RA8CHR_00771 ENOG4105DHQ Histidine kinase RA8CHR_00784 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) RA8CHR_00785 ENOG4106A3M Cytochrome p-450 RA8CHR_00786 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_00788 ENOG4105CSU acyl-Coa dehydrogenase RA8CHR_00789 ENOG4106NZI LysR family Transcriptional regulator RA8CHR_00790 ENOG4105E27 serine threonine protein kinase RA8CHR_00792 ENOG4108ZHJ Organic hydroperoxide resistance protein RA8CHR_00793 ENOG4105K56 Transcriptional regulator RA8CHR_00795 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase RA8CHR_00796 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR RA8CHR_00801 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_00803 ENOG4105C0Z ABC transporter RA8CHR_00804 ENOG4108IV0 ABC, transporter RA8CHR_00815 ENOG4107S78 Band 7 protein RA8CHR_00817 ENOG4105EQN UPF0261 protein RA8CHR_00818 ENOG4105C0Z ABC transporter RA8CHR_00822 ENOG4105CI2 imidazolone-5-propionate hydrolase RA8CHR_00823 ENOG4105CI2 imidazolone-5-propionate hydrolase RA8CHR_00824 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) RA8CHR_00825 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_00828 ENOG4105BZU Histidine kinase RA8CHR_00830 ENOG4108J2P Alpha beta hydrolase fold RA8CHR_00835 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_00837 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) RA8CHR_00838 ENOG4109066 lysm domain bon superfamily protein RA8CHR_00840 ENOG4105CH5 extracellular solute-binding protein, family 7 RA8CHR_00842 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_00842 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_00845 ENOG4105DC8 reductase RA8CHR_00848 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) RA8CHR_00849 ENOG4105FYV Amp nucleosidase RA8CHR_00851 ENOG4108ZHR arsR family transcriptional regulator RA8CHR_00855 ENOG4105HEI LysR family (Transcriptional regulator RA8CHR_00856 ENOG4105CJ1 ABC, transporter RA8CHR_00858 ENOG4106BRA Membrane RA8CHR_00859 ENOG4105CWC Acetylornithine deacetylase RA8CHR_00860 ENOG4105CH2 amidohydrolase RA8CHR_00863 ENOG4108J2R molybdopterin oxidoreductase RA8CHR_00864 ENOG41068KF Universal stress protein RA8CHR_00875 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase RA8CHR_00877 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase RA8CHR_00881 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) RA8CHR_00885 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) RA8CHR_00887 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA8CHR_00888 ENOG4105C5E polysaccharide biosynthesis protein RA8CHR_00890 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase RA8CHR_00895 ENOG4105J5G Transferase hexapeptide repeat containing protein RA8CHR_00901 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA8CHR_00905 ENOG4105C0K Gdp-mannose 4,6-dehydratase RA8CHR_00908 ENOG4105C30 Nad-dependent epimerase dehydratase RA8CHR_00912 ENOG4105CJT Mannose-1-phosphate guanylyltransferase RA8CHR_00913 ENOG4105EXC Acyl-transferase RA8CHR_00915 ENOG4108SHN Glycosyl transferase, family 2 RA8CHR_00918 ENOG4105CAS nag kinase RA8CHR_00920 ENOG4105CMR udp-glucose 4-epimerase RA8CHR_00922 ENOG4105CH6 catalase RA8CHR_00926 ENOG410829K Lysine exporter protein (Lyse ygga) RA8CHR_00927 ENOG4105CHR reductase RA8CHR_00929 ENOG4105IPI Membrane RA8CHR_00932 ENOG4108ZCF integral membrane protein RA8CHR_00938 ENOG4105GAK amidohydrolase 2 RA8CHR_00940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8CHR_00941 ENOG4105RQF LysR family Transcriptional regulator RA8CHR_00942 ENOG4105CD3 dihydroorotase RA8CHR_00944 ENOG4105CGP Urocanate hydratase RA8CHR_00948 ENOG4108T2C cysteine dioxygenase type I RA8CHR_00952 ENOG4107RN6 Monooxygenase RA8CHR_00953 ENOG4105YVM Phosphoesterase, PA-phosphatase related RA8CHR_00956 ENOG4105BZU Histidine kinase RA8CHR_00957 ENOG4105DG4 malate L-lactate dehydrogenase RA8CHR_00958 ENOG4105CTX dehydratase RA8CHR_00959 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_00961 ENOG4108ERU trap dicarboxylate transporter subunit DctP RA8CHR_00962 ENOG4107YCY Transcriptional regulator RA8CHR_00963 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr RA8CHR_00964 ENOG4106517 Short-chain dehydrogenase reductase Sdr RA8CHR_00965 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_00966 ENOG4105C26 Dehydrogenase RA8CHR_00967 ENOG4105EXG Transcriptional regulator RA8CHR_00968 ENOG4105BZU Histidine kinase RA8CHR_00969 ENOG4108ZXC Two component transcriptional regulator, luxr family RA8CHR_00973 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) RA8CHR_00974 ENOG4106YN8 Prenyltransferase RA8CHR_00977 ENOG4105CSU acyl-Coa dehydrogenase RA8CHR_00980 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_00983 ENOG41060WC Enoyl-CoA hydratase RA8CHR_00984 ENOG4105EQR Transposase IS116 IS110 IS902 RA8CHR_00985 ENOG4105NAU thioesterase Superfamily protein RA8CHR_00986 ENOG4108JJ7 ABC transporter RA8CHR_00987 ENOG4105C5I Dehydrogenase RA8CHR_00989 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_00990 ENOG4105CNN ABC, transporter RA8CHR_00991 ENOG4105C0Z ABC transporter RA8CHR_00992 ENOG4108IV0 ABC, transporter RA8CHR_00994 ENOG4105RE0 Asp Glu hydantoin racemase RA8CHR_00997 ENOG4108UAU isochorismatase RA8CHR_00999 ENOG4107YNJ LysR family Transcriptional regulator RA8CHR_01000 ENOG4107RP9 extracellular solute-binding protein, family 3 RA8CHR_01001 ENOG4105EAD ABC transporter RA8CHR_01002 ENOG4105DRP amino acid AbC transporter RA8CHR_01003 ENOG4105CDA abc transporter atp-binding protein RA8CHR_01004 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit RA8CHR_01005 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_01011 ENOG4105C5Q Transcriptional regulator RA8CHR_01014 ENOG4105EA8 2-Nitropropane dioxygenase RA8CHR_01016 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_01017 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_01018 ENOG4105CC9 acyl-Coa dehydrogenase RA8CHR_01019 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_01021 ENOG4105CBN LysR family transcriptional regulator RA8CHR_01022 ENOG4105E33 succinate dehydrogenase RA8CHR_01023 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_01024 ENOG4105J0Q Transcriptional regulator RA8CHR_01025 ENOG4105E7W lamb ycsf family protein RA8CHR_01027 ENOG4105C6T cysteine synthase RA8CHR_01030 ENOG4105EKE dihydroorotase RA8CHR_01038 ENOG4107HP6 Transcriptional regulator RA8CHR_01039 ENOG4105D0M Protease HtpX homolog RA8CHR_01040 ENOG4105DZ0 fad dependent oxidoreductase RA8CHR_01044 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) RA8CHR_01046 ENOG4105FE9 pseudouridine synthase RA8CHR_01047 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) RA8CHR_01049 ENOG4107R0V Pyruvate dehydrogenase RA8CHR_01050 ENOG4105CPP Dehydrogenase, E1 component RA8CHR_01051 ENOG4107QSN dihydrolipoamide acetyltransferase RA8CHR_01053 ENOG4107QX8 SPFH domain, Band 7 family protein RA8CHR_01054 ENOG4105D7N magnesium and cobalt transport protein CorA RA8CHR_01058 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_01063 ENOG4105E1J oxidoreductase RA8CHR_01065 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) RA8CHR_01068 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) RA8CHR_01069 ENOG4105DR4 Methyltransferase RA8CHR_01070 ENOG4105CKI cobalamin synthesis protein RA8CHR_01073 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) RA8CHR_01074 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) RA8CHR_01075 ENOG4108V6E Cell division protein mraZ RA8CHR_01076 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) RA8CHR_01078 ENOG4105CJN penicillin-binding protein RA8CHR_01079 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) RA8CHR_01080 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) RA8CHR_01081 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) RA8CHR_01082 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) RA8CHR_01083 ENOG4105CNI cell division protein FtsW RA8CHR_01084 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) RA8CHR_01085 ENOG4105DFU Cell wall formation (By similarity) RA8CHR_01086 ENOG4105CPF Cell wall formation (By similarity) RA8CHR_01087 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) RA8CHR_01088 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) RA8CHR_01089 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) RA8CHR_01090 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) RA8CHR_01092 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase RA8CHR_01095 ENOG4105K6V RNA polymerase RA8CHR_01099 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) RA8CHR_01100 ENOG4105KNE Phosphatidate cytidylyltransferase RA8CHR_01104 ENOG4105E2X shikimate dehydrogenase RA8CHR_01106 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) RA8CHR_01107 ENOG4105IPS esterase RA8CHR_01108 ENOG4105CNI cell division protein FtsW RA8CHR_01109 ENOG4105D1U peptidase U62 modulator of DNA gyrase RA8CHR_01110 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) RA8CHR_01112 ENOG4105DFU Cell wall formation (By similarity) RA8CHR_01114 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen RA8CHR_01115 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein RA8CHR_01116 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase RA8CHR_01117 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) RA8CHR_01119 ENOG4107T4Z adenosine kinase RA8CHR_01121 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) RA8CHR_01122 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) RA8CHR_01124 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family RA8CHR_01125 ENOG4107TUY Histidine kinase RA8CHR_01128 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY RA8CHR_01129 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) RA8CHR_01130 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family RA8CHR_01132 ENOG4107WP9 Histidine kinase RA8CHR_01133 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) RA8CHR_01135 ENOG4105ENT Efflux transporter rnd family, mfp subunit RA8CHR_01136 ENOG4105BZS acriflavin resistance protein RA8CHR_01145 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) RA8CHR_01147 ENOG4105FGE Short-chain dehydrogenase reductase Sdr RA8CHR_01150 ENOG4105M0Y RA8CHR_01155 ENOG4105CHR reductase RA8CHR_01156 ENOG4105CBN LysR family transcriptional regulator RA8CHR_01157 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_01159 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase RA8CHR_01160 ENOG4105BZP glycoside hydrolase 15-related RA8CHR_01161 ENOG4108K4C ec 3.1.3.12 RA8CHR_01162 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate RA8CHR_01164 ENOG4108302 MgtC SapB transporter RA8CHR_01165 ENOG4105E4C Lytic transglycosylase catalytic RA8CHR_01166 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase RA8CHR_01167 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_01170 ENOG4105DS0 Transcriptional regulator, Crp Fnr family RA8CHR_01174 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) RA8CHR_01175 ENOG4105F7P transcriptional regulator AsnC family RA8CHR_01177 ENOG4108BUD transposase RA8CHR_01188 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_01195 ENOG4105C7F AcnD-accessory protein PrpF RA8CHR_01196 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_01201 ENOG4105CD5 CoA-binding domain protein RA8CHR_01203 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_01204 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_01205 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_01213 ENOG4105DU1 integral membrane protein, terc RA8CHR_01222 ENOG4108MN8 Membrane RA8CHR_01224 ENOG41063Z6 transcriptional regulator, lysR family RA8CHR_01225 ENOG4105CHM Aminotransferase RA8CHR_01227 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) RA8CHR_01229 ENOG4105SB3 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) RA8CHR_01233 ENOG4105CHM Aminotransferase RA8CHR_01234 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_01235 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i RA8CHR_01237 ENOG41067HZ cytochrome C, class I RA8CHR_01240 ENOG4105F9F transposase RA8CHR_01243 ENOG4107GFK fumarate RA8CHR_01245 ENOG4108RXX maleylacetoacetate isomerase RA8CHR_01250 ENOG4105DC8 reductase RA8CHR_01251 ENOG4108Z9W Outer membrane porin RA8CHR_01252 ENOG4105MSY salicylate hydroxylase RA8CHR_01255 ENOG4105VSH 4-oxalocrotonate tautomerase RA8CHR_01258 ENOG4108K2P TRANSCRIPTIONal RA8CHR_01269 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_01270 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_01273 ENOG4105K63 Thioredoxin RA8CHR_01277 ENOG4105C3M thioredoxin reductase RA8CHR_01278 ENOG4105D0M Protease HtpX homolog RA8CHR_01279 ENOG4108ZXC Two component transcriptional regulator, luxr family RA8CHR_01280 ENOG4105ECQ AraC Family Transcriptional Regulator RA8CHR_01281 ENOG4105K3G Periplasmic Protein RA8CHR_01283 ENOG4105VN1 Heat shock protein RA8CHR_01285 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit RA8CHR_01286 ENOG4105BZU Histidine kinase RA8CHR_01287 ENOG4105DRR Transcriptional regulator, GntR family RA8CHR_01290 ENOG4105CTX dehydratase RA8CHR_01291 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_01292 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter RA8CHR_01294 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit RA8CHR_01298 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_01299 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_01301 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_01303 ENOG4105CV8 reductase RA8CHR_01304 ENOG4105F27 Major Facilitator RA8CHR_01305 ENOG4105HEI LysR family (Transcriptional regulator RA8CHR_01311 ENOG4108IG5 Transcriptional regulator RA8CHR_01312 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) RA8CHR_01320 ENOG4105C0H protease RA8CHR_01322 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein RA8CHR_01331 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i RA8CHR_01338 ENOG4105DS0 Transcriptional regulator, Crp Fnr family RA8CHR_01339 ENOG4105D4P Coproporphyrinogen iii oxidase RA8CHR_01341 ENOG4105CD5 CoA-binding domain protein RA8CHR_01342 ENOG4105CY0 Metallo-Beta-Lactamase RA8CHR_01343 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) RA8CHR_01345 ENOG4105DS0 Transcriptional regulator, Crp Fnr family RA8CHR_01347 ENOG4105DPZ Two component transcriptional regulator (Winged helix family RA8CHR_01349 ENOG4105EAQ (twin-arginine translocation) pathway signal RA8CHR_01356 ENOG4105CHR reductase RA8CHR_01358 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class RA8CHR_01360 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic RA8CHR_01362 ENOG41080TK Universal stress protein RA8CHR_01366 ENOG4107QRI Phosphoketolase RA8CHR_01369 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_01370 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_01375 ENOG4105WD1 Membrane RA8CHR_01382 ENOG4105CC0 LysR family Transcriptional regulator RA8CHR_01384 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase RA8CHR_01385 ENOG4105CS1 NAD(P)H quinone oxidoreductase RA8CHR_01389 ENOG4105EUF amidase EC 3.5.1.4 RA8CHR_01392 ENOG4105CMT Dihydroxyacetone kinase RA8CHR_01394 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) RA8CHR_01396 ENOG4105CF7 AraC family transcriptional regulator RA8CHR_01402 ENOG4108MJI response regulator RA8CHR_01413 ENOG4105DS1 cytochrome b561 RA8CHR_01414 ENOG4105EQ0 Major Facilitator superfamily RA8CHR_01415 ENOG4105HEI LysR family (Transcriptional regulator RA8CHR_01417 ENOG4105F4K antigen 43 RA8CHR_01418 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) RA8CHR_01419 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) RA8CHR_01422 ENOG4105CG3 alpha amylase, catalytic region RA8CHR_01423 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) RA8CHR_01424 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) RA8CHR_01431 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) RA8CHR_01437 ENOG4105BZ1 (ABC) transporter RA8CHR_01439 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) RA8CHR_01440 ENOG4105CQ0 ABC transporter RA8CHR_01442 ENOG4105D7Q type ii secretion system RA8CHR_01444 ENOG4107QHF type ii secretion system protein e RA8CHR_01453 ENOG4108VAU general secretion pathway protein G RA8CHR_01455 ENOG4105C7B Threonine dehydratase RA8CHR_01457 ENOG4108UKZ OsmC family RA8CHR_01458 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) RA8CHR_01459 ENOG4108Z9W Outer membrane porin RA8CHR_01460 ENOG4105DEF Extracellular solute-binding protein, family 5 RA8CHR_01462 ENOG4105CH2 amidohydrolase RA8CHR_01463 ENOG4108J59 Extracellular solute-binding protein, family 5 RA8CHR_01464 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA8CHR_01465 ENOG4105C3U ABC transporter RA8CHR_01466 ENOG4108JQ7 (ABC) transporter RA8CHR_01467 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase RA8CHR_01470 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) RA8CHR_01471 ENOG4107QP8 phosphohexose isomerase RA8CHR_01472 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) RA8CHR_01474 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) RA8CHR_01475 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) RA8CHR_01477 ENOG4105FP9 thiamine pyrophosphate RA8CHR_01481 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) RA8CHR_01490 ENOG4105R0I Feruloyl esterase RA8CHR_01494 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_01495 ENOG4108JQ1 Dehydrogenase RA8CHR_01496 ENOG4105JSC dimethylmenaquinone methyltransferase RA8CHR_01505 ENOG4105CHB tonB-dependent Receptor RA8CHR_01507 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP RA8CHR_01509 ENOG4105D1S lipid A biosynthesis RA8CHR_01510 ENOG4105D74 hydrolase RA8CHR_01511 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) RA8CHR_01512 ENOG4106RE7 Cytochrome RA8CHR_01514 ENOG4105CRE cytochrome C RA8CHR_01515 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) RA8CHR_01516 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) RA8CHR_01517 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) RA8CHR_01518 ENOG4105XQ6 frataxin-like protein RA8CHR_01519 ENOG4108JQC penicillin-binding protein 1A RA8CHR_01524 ENOG4105E4G Type IV pilus RA8CHR_01525 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) RA8CHR_01527 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein RA8CHR_01534 ENOG4105DHJ ABC, transporter RA8CHR_01535 ENOG4105CY3 ABC transporter, permease RA8CHR_01536 ENOG4107PE3 Mammalian cell entry related domain protein RA8CHR_01540 ENOG4105DA5 (ABC) transporter RA8CHR_01541 ENOG4105E3A (ABC) transporter RA8CHR_01542 ENOG4105VFK BolA family RA8CHR_01543 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) RA8CHR_01544 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) RA8CHR_01547 ENOG4105CIH Imidazole acetol-phosphate transaminase RA8CHR_01548 ENOG4105ECC imidazole-glycerol-phosphate dehydratase RA8CHR_01550 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase RA8CHR_01551 ENOG4105F4K antigen 43 RA8CHR_01552 ENOG4105DSB aldose 1-epimerase RA8CHR_01553 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) RA8CHR_01554 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase RA8CHR_01555 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase RA8CHR_01557 ENOG4107YU2 histidine triad (hIT) protein RA8CHR_01558 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) RA8CHR_01559 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) RA8CHR_01560 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) RA8CHR_01561 ENOG4105C0H protease RA8CHR_01562 ENOG4107QNR UPF0135 protein RA8CHR_01563 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) RA8CHR_01564 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) RA8CHR_01565 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) RA8CHR_01566 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) RA8CHR_01567 ENOG4105EIX cytochrome c1 RA8CHR_01568 ENOG4107MKT Stringent starvation protein a RA8CHR_01569 ENOG4105KB2 stringent starvation protein b RA8CHR_01571 ENOG4108UAU isochorismatase RA8CHR_01574 ENOG4105RE0 Asp Glu hydantoin racemase RA8CHR_01582 ENOG4105CH5 extracellular solute-binding protein, family 7 RA8CHR_01584 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_01588 ENOG4107Z6I Thiamine biosynthesis protein RA8CHR_01590 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_01597 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving RA8CHR_01600 ENOG4105M6F mutator MutT protein RA8CHR_01601 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) RA8CHR_01604 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein RA8CHR_01608 ENOG4107QHF type ii secretion system protein e RA8CHR_01610 ENOG4108KMV Glycosyl transferase (Group 1 RA8CHR_01614 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) RA8CHR_01618 ENOG4105C6Y Udp-glucose 6-dehydrogenase RA8CHR_01620 ENOG4106WTF Glycosyl transferase, family 2 RA8CHR_01621 ENOG4105CH7 arginosuccinase RA8CHR_01622 ENOG4108HRK Histidine kinase RA8CHR_01623 ENOG4108NEV two component transcriptional regulator, LytTR family RA8CHR_01624 ENOG4105DSF transport protein RA8CHR_01627 ENOG4105CSH Transporter RA8CHR_01630 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) RA8CHR_01634 ENOG4105DIA mandelate racemase muconate lactonizing RA8CHR_01637 ENOG4105HSS phospholipase C RA8CHR_01640 ENOG4105D5T phosphonate abc transporter RA8CHR_01643 ENOG4106KNT transcriptional regulator RA8CHR_01645 ENOG4105C26 Dehydrogenase RA8CHR_01648 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_01649 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter RA8CHR_01650 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit RA8CHR_01652 ENOG4105CTX dehydratase RA8CHR_01653 ENOG4105CXK mandelate racemase muconate lactonizing RA8CHR_01654 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) RA8CHR_01661 ENOG4105HSS phospholipase C RA8CHR_01662 ENOG4106KNT transcriptional regulator RA8CHR_01663 ENOG4105BZ4 penicillin-binding protein RA8CHR_01665 ENOG4105KA0 thioesterase Superfamily protein RA8CHR_01671 ENOG4105CMM transposase RA8CHR_01674 ENOG4105NI8 Cytosine-specific methyltransferase RA8CHR_01675 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) RA8CHR_01676 ENOG4105DZR Type I site-specific deoxyribonuclease RA8CHR_01678 ENOG4107QTH restriction modification system DNA specificity domain RA8CHR_01679 ENOG4105CVR type I restriction-modification system RA8CHR_01689 ENOG4105EAH synthase RA8CHR_01690 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) RA8CHR_01691 ENOG4105K46 50S ribosomal protein l27 RA8CHR_01692 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control RA8CHR_01693 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) RA8CHR_01695 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) RA8CHR_01696 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) RA8CHR_01697 ENOG4105E4C Lytic transglycosylase catalytic RA8CHR_01698 ENOG4105C37 (CBS) domain RA8CHR_01699 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) RA8CHR_01702 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) RA8CHR_01703 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) RA8CHR_01704 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) RA8CHR_01706 ENOG4105EGS Mechanosensitive ion channel RA8CHR_01707 ENOG4107T6V glycerophosphoryl diester phosphodiesterase RA8CHR_01708 ENOG4108IJ9 (ABC) transporter RA8CHR_01710 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component RA8CHR_01712 ENOG4108JQ1 Dehydrogenase RA8CHR_01716 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) RA8CHR_01719 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) RA8CHR_01720 ENOG4108IA2 Sodium pantothenate symporter RA8CHR_01723 ENOG4105C9M aspartyl-trna synthetase RA8CHR_01725 ENOG4105X23 Endonuclease Exonuclease phosphatase RA8CHR_01726 ENOG4105EUJ GTP cyclohydrolase i RA8CHR_01734 ENOG4106H29 UPF0391 membrane protein RA8CHR_01735 ENOG4105BZU Histidine kinase RA8CHR_01736 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_01739 ENOG41066T0 asmA family RA8CHR_01740 ENOG4105D06 uba thif-type nad fad binding protein RA8CHR_01741 ENOG4105CN1 protease RA8CHR_01742 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) RA8CHR_01743 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) RA8CHR_01744 ENOG4105VW4 glutaredoxin 3 RA8CHR_01745 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) RA8CHR_01746 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase RA8CHR_01747 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase RA8CHR_01748 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) RA8CHR_01750 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase RA8CHR_01751 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) RA8CHR_01752 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) RA8CHR_01753 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) RA8CHR_01754 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) RA8CHR_01755 ENOG4108IYU L-aspartate oxidase RA8CHR_01759 ENOG4105CHH sulfate transporter RA8CHR_01761 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) RA8CHR_01762 ENOG4108YXG UPF0502 protein RA8CHR_01764 ENOG4105C5Q Transcriptional regulator RA8CHR_01767 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) RA8CHR_01773 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) RA8CHR_01774 ENOG4105QAX Iron-sulfur RA8CHR_01779 ENOG4105CV6 ABC transporter, permease RA8CHR_01781 ENOG4105C28 cystathionine RA8CHR_01783 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) RA8CHR_01784 ENOG4108RAC Rubrerythrin RA8CHR_01791 ENOG4105W5Q DNA repair protein (RadC RA8CHR_01792 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase RA8CHR_01793 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) RA8CHR_01794 ENOG4105C7B Threonine dehydratase RA8CHR_01796 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) RA8CHR_01805 ENOG4105H3G oxidoreductase RA8CHR_01807 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) RA8CHR_01813 ENOG4107SQD Transcriptional regulator, GntR family RA8CHR_01814 ENOG4105CHR reductase RA8CHR_01815 ENOG4105CJW magnesium transporter RA8CHR_01817 ENOG4105C7I Dehydrogenase RA8CHR_01819 ENOG4105BZU Histidine kinase RA8CHR_01821 ENOG4105C31 Tryptophanyl-tRNA synthetase RA8CHR_01822 ENOG4108Z4T Peptidase M50 RA8CHR_01823 ENOG4107RTD sua5 ycio yrdc ywlc family protein RA8CHR_01825 ENOG4105DB7 PHP domain protein RA8CHR_01827 ENOG4105CSR polyphosphate kinase 2 RA8CHR_01830 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein RA8CHR_01831 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_01833 ENOG4105C0Z ABC transporter RA8CHR_01834 ENOG4108IV0 ABC, transporter RA8CHR_01837 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_01841 ENOG4105CDA abc transporter atp-binding protein RA8CHR_01842 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) RA8CHR_01844 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) RA8CHR_01846 ENOG4105E5Q amino acid AbC transporter RA8CHR_01849 ENOG41079KZ Major Facilitator Superfamily RA8CHR_01850 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) RA8CHR_01851 ENOG4108Z6B deaminase RA8CHR_01854 ENOG4105CC9 acyl-Coa dehydrogenase RA8CHR_01856 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_01857 ENOG4108UKI Enoyl-CoA hydratase RA8CHR_01859 ENOG4108UKI Enoyl-CoA hydratase RA8CHR_01860 ENOG4108WYP Transcriptional regulator RA8CHR_01861 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_01862 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_01863 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase RA8CHR_01864 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_01871 ENOG4105C0Z ABC transporter RA8CHR_01872 ENOG4108IV0 ABC, transporter RA8CHR_01873 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_01874 ENOG4105CC9 acyl-Coa dehydrogenase RA8CHR_01875 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_01884 ENOG4105EYW Ion transport protein RA8CHR_01886 ENOG4105CS1 NAD(P)H quinone oxidoreductase RA8CHR_01889 ENOG4105BZU Histidine kinase RA8CHR_01890 ENOG4108TJN glycosyl transferase group 1 RA8CHR_01899 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) RA8CHR_01906 ENOG4105E6M Sulphatase-modifying factor protein RA8CHR_01909 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_01911 ENOG4105EAM Na Pi-cotransporter RA8CHR_01914 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_01917 ENOG4107UXM Membrane RA8CHR_01921 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_01922 ENOG4105D7T ABC transporter RA8CHR_01926 ENOG4105C6K Malic enzyme RA8CHR_01932 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) RA8CHR_01934 ENOG4107E2E PKHD-type hydroxylase RA8CHR_01942 ENOG4105CMJ mandelate racemase muconate lactonizing RA8CHR_01943 ENOG4107YNJ LysR family Transcriptional regulator RA8CHR_01944 ENOG4105BZU Histidine kinase RA8CHR_01949 ENOG4105EIG urea carboxylase-associated protein 1 RA8CHR_01954 ENOG4105DEN Luciferase family RA8CHR_01956 ENOG4105CMD Transcriptional regulator, GntR family RA8CHR_01958 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_01959 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_01965 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_01966 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_01978 ENOG410811B TRANSCRIPTIONal RA8CHR_01980 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) RA8CHR_01981 ENOG4108JQ7 (ABC) transporter RA8CHR_01983 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA8CHR_01987 ENOG4108MP6 LysR family Transcriptional regulator RA8CHR_01992 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_01994 ENOG4106FTQ Taurine ABC transporter, periplasmic RA8CHR_01996 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_01997 ENOG4105CYM Glutathione S-transferase RA8CHR_01998 ENOG4105CSH Transporter RA8CHR_02000 ENOG4108FUF Transcriptional regulator, IclR family RA8CHR_02005 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_02006 ENOG4105CD5 CoA-binding domain protein RA8CHR_02015 ENOG4105HEI LysR family (Transcriptional regulator RA8CHR_02017 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_02018 ENOG4108EKI Dehydrogenase RA8CHR_02036 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_02037 ENOG4105ENE Histidine kinase RA8CHR_02040 ENOG4108FUF Transcriptional regulator, IclR family RA8CHR_02043 ENOG4105DUM transcriptional regulator, lysR family RA8CHR_02044 ENOG4105DB1 molybdopterin oxidoreductase RA8CHR_02045 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein RA8CHR_02046 ENOG4108KDI dmso reductase anchor subunit RA8CHR_02050 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) RA8CHR_02054 ENOG4107RZC phospholipase d RA8CHR_02060 ENOG41082BM Transcriptional regulator, arsr family RA8CHR_02061 ENOG4105HSS phospholipase C RA8CHR_02063 ENOG4105BZU Histidine kinase RA8CHR_02064 ENOG4107QVM von Willebrand factor, type A RA8CHR_02068 ENOG4105EJC lysr family transcriptional regulator RA8CHR_02070 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_02075 ENOG4108ZC9 flagellar basal-body rod protein flgc RA8CHR_02076 ENOG4105W00 Flagellar hook capping protein RA8CHR_02077 ENOG4105BZE flagellar hook protein, FlgE RA8CHR_02078 ENOG4108KPB Flagellar basal-body rod protein FlgF RA8CHR_02079 ENOG4105CGA flagellar basal-body rod protein FlgG RA8CHR_02080 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) RA8CHR_02082 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj RA8CHR_02083 ENOG4108V3W Chemotaxis protein, CheW RA8CHR_02084 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_02085 ENOG4108V3W Chemotaxis protein, CheW RA8CHR_02086 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_02087 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_02088 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_02089 ENOG4105E1Q flagellar hook-associated protein RA8CHR_02090 ENOG4105DTJ flagellar hook-associated protein RA8CHR_02092 ENOG4108SVW integral membrane protein RA8CHR_02093 ENOG4106HB6 Alpha beta hydrolase RA8CHR_02100 ENOG4105E0F Histidine kinase RA8CHR_02104 ENOG4105EXG Transcriptional regulator RA8CHR_02105 ENOG4105CHR reductase RA8CHR_02107 ENOG4108ZHJ Organic hydroperoxide resistance protein RA8CHR_02109 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_02110 ENOG410846T CoA-transferase family III RA8CHR_02113 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_02115 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_02118 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) RA8CHR_02119 ENOG4105BZ9 Cytochrome C oxidase, subunit I RA8CHR_02122 ENOG4105CCU oxidase (Subunit III) RA8CHR_02127 ENOG4105D19 Role in flagellar biosynthesis (By similarity) RA8CHR_02129 ENOG4105VS8 Flagellar biosynthetic protein fliq RA8CHR_02130 ENOG4105CN7 Flagellar biosynthetic protein FliP RA8CHR_02132 ENOG4105DD5 Flagellar motor switch protein RA8CHR_02133 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) RA8CHR_02134 ENOG4107ZI8 flagellar basal body-associated protein flil RA8CHR_02135 ENOG4105WF4 Flagellar hook-length control protein RA8CHR_02136 ENOG4105GSA Flagellar export protein flij RA8CHR_02137 ENOG4108JIR Flagellum-specific ATP synthase RA8CHR_02138 ENOG4108CG0 Flagellar assembly protein RA8CHR_02139 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) RA8CHR_02140 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) RA8CHR_02142 ENOG4105I03 Flagellin RA8CHR_02143 ENOG41063QE flagellar protein FlaG RA8CHR_02144 ENOG4105DTS flagellar hook-associated RA8CHR_02145 ENOG4105MQ3 flagellar protein FliS RA8CHR_02148 ENOG4105D00 flagellar biosynthetic protein flhB RA8CHR_02150 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region RA8CHR_02151 ENOG4107RD7 Flagellar Motor Protein, MotA RA8CHR_02152 ENOG4105ER2 Ompa motb domain protein RA8CHR_02153 ENOG4105CBS Chea signal transduction histidine kinase RA8CHR_02154 ENOG4105D58 Diguanylate phosphodiesterase RA8CHR_02155 ENOG4105BZU Histidine kinase RA8CHR_02159 ENOG4108VYJ response regulator receiver protein RA8CHR_02160 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) RA8CHR_02164 ENOG4105D00 flagellar biosynthetic protein flhB RA8CHR_02165 ENOG4105D7B Flagellar biosynthesis protein flha RA8CHR_02166 ENOG4105FZW flagellar biosynthesis regulator FlhF RA8CHR_02168 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA8CHR_02172 ENOG4105TV9 FHA Domain-Containing protein RA8CHR_02176 ENOG4105CMM transposase RA8CHR_02179 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 RA8CHR_02180 ENOG4105CD8 aminopeptidase N RA8CHR_02181 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) RA8CHR_02182 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) RA8CHR_02183 ENOG4105CPC Aldo Keto reductase RA8CHR_02184 ENOG4108Z66 YbaK ebsC protein RA8CHR_02185 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) RA8CHR_02186 ENOG4105M4H endoribonuclease L-psp RA8CHR_02188 ENOG4108VPT UPF0234 protein RA8CHR_02189 ENOG4105D4A Cell wall formation (By similarity) RA8CHR_02190 ENOG4105CDH Citrulline--aspartate ligase RA8CHR_02191 ENOG4105NBK UPF0345 protein RA8CHR_02193 ENOG4105KUZ arsenate reductase RA8CHR_02194 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase RA8CHR_02197 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase RA8CHR_02198 ENOG4105C28 cystathionine RA8CHR_02199 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) RA8CHR_02204 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_02205 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_02207 ENOG410811B TRANSCRIPTIONal RA8CHR_02208 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) RA8CHR_02212 ENOG4105C7W Xanthine dehydrogenase RA8CHR_02214 ENOG4105C7N Xanthine uracil vitamin C permease RA8CHR_02215 ENOG4108JQ9 ABC transporter RA8CHR_02216 ENOG4105UIB (ABC) transporter RA8CHR_02220 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) RA8CHR_02223 ENOG4105BZU Histidine kinase RA8CHR_02224 ENOG4107QHF type ii secretion system protein e RA8CHR_02225 ENOG4105BZU Histidine kinase RA8CHR_02228 ENOG4108TJN glycosyl transferase group 1 RA8CHR_02229 ENOG4107QUY Guanine deaminase RA8CHR_02230 ENOG4105DHP deoxycytidine triphosphate deaminase RA8CHR_02231 ENOG4105CGZ zinc metallopeptidase RA8CHR_02232 ENOG4105C1J atp-dependent rna helicase RA8CHR_02233 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) RA8CHR_02234 ENOG4105EE5 Membrane protein terC RA8CHR_02243 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8CHR_02244 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) RA8CHR_02245 ENOG41060W2 glyoxylate carboligase RA8CHR_02246 ENOG4105CC0 LysR family Transcriptional regulator RA8CHR_02247 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_02257 ENOG4107YCY Transcriptional regulator RA8CHR_02258 ENOG4105CK2 sodium dicarboxylate symporter RA8CHR_02270 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme RA8CHR_02271 ENOG4105CYX Short-chain dehydrogenase reductase Sdr RA8CHR_02277 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_02278 ENOG4105CYM Glutathione S-transferase RA8CHR_02279 ENOG4108K3A Glutathione S-transferase RA8CHR_02280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase RA8CHR_02282 ENOG4105CBN LysR family transcriptional regulator RA8CHR_02283 ENOG4105ENT Efflux transporter rnd family, mfp subunit RA8CHR_02286 ENOG4105ENJ RND efflux system, outer membrane lipoprotein RA8CHR_02287 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase RA8CHR_02289 ENOG4108YYH Nadph-dependent fmn reductase RA8CHR_02294 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_02296 ENOG4105CH5 extracellular solute-binding protein, family 7 RA8CHR_02302 ENOG4105CHR reductase RA8CHR_02304 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_02308 ENOG4105DWV Homoserine O-trans-acetylase RA8CHR_02309 ENOG4105CXK mandelate racemase muconate lactonizing RA8CHR_02310 ENOG4105C5I Dehydrogenase RA8CHR_02311 ENOG4105CXK mandelate racemase muconate lactonizing RA8CHR_02313 ENOG4105CZE histidine utilization repressor RA8CHR_02314 ENOG4105EXG Transcriptional regulator RA8CHR_02316 ENOG4105CJP fad dependent oxidoreductase RA8CHR_02318 ENOG4105CH2 amidohydrolase RA8CHR_02319 ENOG4108RYR transcriptional regulator AsnC family RA8CHR_02325 ENOG4105CJP fad dependent oxidoreductase RA8CHR_02326 ENOG4108J59 Extracellular solute-binding protein, family 5 RA8CHR_02328 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA8CHR_02330 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) RA8CHR_02331 ENOG4105C26 Dehydrogenase RA8CHR_02332 ENOG4108DN8 FAD dependent oxidoreductase RA8CHR_02334 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_02335 ENOG4105CBG Sulfatase RA8CHR_02336 ENOG4105DDW LysR family Transcriptional regulator RA8CHR_02337 ENOG4105CQB FAD linked oxidase domain protein RA8CHR_02341 ENOG4108M9J MaoC like domain protein RA8CHR_02343 ENOG4105CI0 Citrate lyase RA8CHR_02344 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase RA8CHR_02345 ENOG4105F04 LysR family Transcriptional regulator RA8CHR_02347 ENOG4105C7F AcnD-accessory protein PrpF RA8CHR_02348 ENOG4108Z9W Outer membrane porin RA8CHR_02349 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit RA8CHR_02350 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_02351 ENOG4105ETE Transcriptional regulator (LacI family RA8CHR_02353 ENOG4105GAK amidohydrolase 2 RA8CHR_02354 ENOG4105C0H protease RA8CHR_02355 ENOG4108YV4 Universal stress protein RA8CHR_02363 ENOG4107Y70 Heat shock protein RA8CHR_02365 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) RA8CHR_02366 ENOG4105C0H protease RA8CHR_02369 ENOG41080TK Universal stress protein RA8CHR_02372 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) RA8CHR_02381 ENOG4107RCI amp-dependent synthetase and ligase RA8CHR_02385 ENOG4108JYK Dehydrogenase RA8CHR_02386 ENOG4105CPP Dehydrogenase, E1 component RA8CHR_02388 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) RA8CHR_02389 ENOG4105TMB Formate nitrite transporter RA8CHR_02391 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_02392 ENOG4105C5T Phosphoribosyl pyrophosphate synthase RA8CHR_02394 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) RA8CHR_02396 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) RA8CHR_02406 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit RA8CHR_02407 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) RA8CHR_02409 ENOG4105XJC Two component transcriptional regulator (Winged helix family RA8CHR_02410 ENOG4105DHQ Histidine kinase RA8CHR_02414 ENOG4108IQE Amp-dependent synthetase and ligase RA8CHR_02417 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) RA8CHR_02418 ENOG4105D60 lipoprotein releasing system transmembrane protein RA8CHR_02420 ENOG4108IRC dna polymerase iii RA8CHR_02421 ENOG4105DPZ Two component transcriptional regulator (Winged helix family RA8CHR_02425 ENOG4107QN1 sodium solute RA8CHR_02426 ENOG41062QD Membrane RA8CHR_02432 ENOG4105BZU Histidine kinase RA8CHR_02433 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_02436 ENOG4105CRU nitrate reductase, alpha subunit RA8CHR_02437 ENOG4108IUE nitrate reductase beta subunit RA8CHR_02438 ENOG4105R3A Nitrate reductase RA8CHR_02439 ENOG4105D0D Nitrate reductase 2, gamma subunit RA8CHR_02440 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) RA8CHR_02446 ENOG41080TK Universal stress protein RA8CHR_02459 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_02461 ENOG4105BZU Histidine kinase RA8CHR_02468 ENOG4105C7W Xanthine dehydrogenase RA8CHR_02469 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding RA8CHR_02470 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit RA8CHR_02471 ENOG4105ECQ AraC Family Transcriptional Regulator RA8CHR_02472 ENOG4105F27 Major Facilitator RA8CHR_02474 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) RA8CHR_02477 ENOG4105EJC lysr family transcriptional regulator RA8CHR_02490 ENOG4105CV8 reductase RA8CHR_02491 ENOG4105C2W permease RA8CHR_02496 ENOG4107QN2 dihydrolipoyl dehydrogenase RA8CHR_02498 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein RA8CHR_02499 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) RA8CHR_02502 ENOG4107YCY Transcriptional regulator RA8CHR_02510 ENOG4105CJ1 ABC, transporter RA8CHR_02511 ENOG4107QWP ABC-2 type transporter RA8CHR_02512 ENOG4107QWP ABC-2 type transporter RA8CHR_02519 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein RA8CHR_02526 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_02527 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase RA8CHR_02528 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase RA8CHR_02531 ENOG4105R0I Feruloyl esterase RA8CHR_02539 ENOG4105DKB L-sorbosone dehydrogenase RA8CHR_02543 ENOG4105D9P serine threonine protein kinase RA8CHR_02551 ENOG4105CDV Ompa motb domain protein RA8CHR_02561 ENOG4105EMN RNA polymerase sigma factor RA8CHR_02566 ENOG4105C59 p-type ATPase RA8CHR_02568 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding RA8CHR_02571 ENOG4107RT3 EamA-like transporter family RA8CHR_02574 ENOG4107QKV phosphomannomutase RA8CHR_02575 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase RA8CHR_02583 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) RA8CHR_02586 ENOG4105YA8 Transcriptional regulator RA8CHR_02587 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) RA8CHR_02591 ENOG4105CPF Cell wall formation (By similarity) RA8CHR_02592 ENOG4105CFH Aspartokinase RA8CHR_02593 ENOG4105CPC Aldo Keto reductase RA8CHR_02598 ENOG4105C01 Dihydroxy-acid dehydratase RA8CHR_02599 ENOG4108UHU Aldolase RA8CHR_02601 ENOG4108UYE Lactoylglutathione lyase RA8CHR_02602 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) RA8CHR_02605 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_02606 ENOG4105EA8 2-Nitropropane dioxygenase RA8CHR_02607 ENOG4107GJV short-chain dehydrogenase reductase RA8CHR_02609 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_02610 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_02611 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr RA8CHR_02612 ENOG4105CHR reductase RA8CHR_02615 ENOG4105DIQ Transcriptional regulator RA8CHR_02620 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_02621 ENOG4105D7K pfkb domain protein RA8CHR_02631 ENOG4108RTU Aldolase RA8CHR_02633 ENOG4105C01 Dihydroxy-acid dehydratase RA8CHR_02634 ENOG4105C5I Dehydrogenase RA8CHR_02635 ENOG4107EJG GntR family transcriptional regulator RA8CHR_02637 ENOG4105D56 permease protein RA8CHR_02640 ENOG4105C1J atp-dependent rna helicase RA8CHR_02642 ENOG4105C5H ABC transporter RA8CHR_02643 ENOG4105D8V Glucose sorbosone dehydrogenase RA8CHR_02645 ENOG4108KX4 response regulator RA8CHR_02648 ENOG4105KXX peptidase s58 dmpa RA8CHR_02650 ENOG4105W1Y Transcriptional regulator RA8CHR_02651 ENOG4107VXM glycerophosphoryl diester phosphodiesterase RA8CHR_02654 ENOG4105E5Q amino acid AbC transporter RA8CHR_02656 ENOG4105DRP amino acid AbC transporter RA8CHR_02657 ENOG4107RP9 extracellular solute-binding protein, family 3 RA8CHR_02659 ENOG4108Z9K Osmotically inducible protein RA8CHR_02660 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_02664 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase RA8CHR_02667 ENOG41067HS methyltransferase RA8CHR_02670 ENOG41081QV Universal stress protein RA8CHR_02671 ENOG4105D3G Pseudouridine synthase RA8CHR_02676 ENOG4105CKW Inner membrane protein yedI RA8CHR_02677 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) RA8CHR_02679 ENOG4105F4K antigen 43 RA8CHR_02682 ENOG4106CJB Phospholipase Carboxylesterase RA8CHR_02683 ENOG4105D9M gamma-glutamylcysteine synthetase RA8CHR_02684 ENOG4107QWB Ornithine cyclodeaminase RA8CHR_02685 ENOG4108UYB regulatoR RA8CHR_02687 ENOG4105VUF Transcriptional regulator RA8CHR_02688 ENOG4105F0I Aminotransferase RA8CHR_02690 ENOG4108VAC response regulator RA8CHR_02691 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) RA8CHR_02704 ENOG4107XZC Restriction modification system DNA (Specificity RA8CHR_02707 ENOG4105CX6 glutaminyL-tRNA synthetase RA8CHR_02709 ENOG4108VAC response regulator RA8CHR_02710 ENOG4108HRK Histidine kinase RA8CHR_02716 ENOG4105ENJ RND efflux system, outer membrane lipoprotein RA8CHR_02719 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) RA8CHR_02724 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) RA8CHR_02726 ENOG41061MV Arylsulfatase RA8CHR_02727 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_02729 ENOG4108VHT MarR family transcriptional regulator RA8CHR_02731 ENOG4105DDW LysR family Transcriptional regulator RA8CHR_02734 ENOG4105ECY inositol monophosphatase RA8CHR_02736 ENOG4105D7W serine acetyltransferase RA8CHR_02737 ENOG4108RIR Molybdenum cofactor biosynthesis protein RA8CHR_02739 ENOG4105CMS peptidase U62, modulator of DNA gyrase RA8CHR_02741 ENOG4105VCC 30S ribosomal protein S21 RA8CHR_02742 ENOG4105CBX hi0933 family RA8CHR_02744 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) RA8CHR_02745 ENOG4108MTB glycosyl transferase family RA8CHR_02748 ENOG4108IFG nitrite reductase, (NAD(P)H) RA8CHR_02752 ENOG4105D7T ABC transporter RA8CHR_02754 ENOG4105I5W Transporter RA8CHR_02756 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) RA8CHR_02758 ENOG4107Y70 Heat shock protein RA8CHR_02759 ENOG4105ES9 amino acid RA8CHR_02761 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) RA8CHR_02762 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) RA8CHR_02764 ENOG4105CP7 Triose-phosphate isomerase RA8CHR_02765 ENOG4107EJC Preprotein translocase subunit SecG RA8CHR_02767 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain RA8CHR_02768 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) RA8CHR_02769 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain RA8CHR_02770 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) RA8CHR_02771 ENOG4105GKE subunit e RA8CHR_02772 ENOG4107QIZ NADH dehydrogenase RA8CHR_02774 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) RA8CHR_02775 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) RA8CHR_02776 ENOG4105DF2 NADH dehydrogenase subunit j RA8CHR_02777 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) RA8CHR_02779 ENOG4105C8S subunit m RA8CHR_02780 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) RA8CHR_02783 ENOG4108YZ4 nudix hydrolase RA8CHR_02785 ENOG4105BZ1 (ABC) transporter RA8CHR_02786 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes RA8CHR_02788 ENOG4105CW7 secretion protein, HlyD family RA8CHR_02789 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA8CHR_02790 ENOG4105C0Z ABC transporter RA8CHR_02791 ENOG4108IV0 ABC, transporter RA8CHR_02794 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_02801 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_02803 ENOG4105CSH Transporter RA8CHR_02805 ENOG4108SHN Glycosyl transferase, family 2 RA8CHR_02811 ENOG4105DIJ Phosphoethanolamine transferase RA8CHR_02813 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_02814 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_02815 ENOG4105CGP Urocanate hydratase RA8CHR_02818 ENOG4105C5Q Transcriptional regulator RA8CHR_02820 ENOG4107REC cytoplasmic protein RA8CHR_02821 ENOG4108IV0 ABC, transporter RA8CHR_02822 ENOG4105CF8 branched-chain amino acid ABC transporter, permease RA8CHR_02823 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_02828 ENOG4105JXH GntR family transcriptional regulator RA8CHR_02830 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_02831 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_02832 ENOG4105EXG Transcriptional regulator RA8CHR_02834 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) RA8CHR_02835 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) RA8CHR_02836 ENOG4105C2C drug resistance transporter, Bcr CflA RA8CHR_02838 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) RA8CHR_02839 ENOG4105DQR SNARE associated Golgi RA8CHR_02842 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase RA8CHR_02843 ENOG4105K8N protein family UPF0079, ATPase RA8CHR_02844 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) RA8CHR_02848 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) RA8CHR_02855 ENOG4105ED9 Protein of unknown function (DUF455) RA8CHR_02856 ENOG4108Z0R Transferase RA8CHR_02857 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) RA8CHR_02860 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) RA8CHR_02861 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) RA8CHR_02863 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase RA8CHR_02864 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) RA8CHR_02865 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase RA8CHR_02867 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) RA8CHR_02870 ENOG4108YZY peptidylprolyl cis-trans isomerase RA8CHR_02871 ENOG4105EZE Cupin 4 family protein RA8CHR_02874 ENOG4105Q2H domain protein RA8CHR_02875 ENOG4105GJM (LipO)protein RA8CHR_02876 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) RA8CHR_02880 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA8CHR_02882 ENOG4105EMN RNA polymerase sigma factor RA8CHR_02883 ENOG4105E4C Lytic transglycosylase catalytic RA8CHR_02886 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA8CHR_02891 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) RA8CHR_02893 ENOG4105E5Q amino acid AbC transporter RA8CHR_02894 ENOG4105E5Q amino acid AbC transporter RA8CHR_02895 ENOG4105EAB amino acid AbC transporter RA8CHR_02896 ENOG4105CDA abc transporter atp-binding protein RA8CHR_02898 ENOG4105D7K pfkb domain protein RA8CHR_02899 ENOG4105C5I Dehydrogenase RA8CHR_02900 ENOG4108M60 Transcriptional regulator RA8CHR_02904 ENOG4105C26 Dehydrogenase RA8CHR_02905 ENOG4108UYU AsnC family transcriptional regulator RA8CHR_02910 ENOG4108EC8 DNA internalization-related competence protein ComEC RA8CHR_02913 ENOG4108JJA ABC, transporter RA8CHR_02914 ENOG4105C42 Type I secretion membrane fusion protein (HlyD RA8CHR_02917 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) RA8CHR_02918 ENOG4105E98 transcriptional regulator DeoR family RA8CHR_02919 ENOG4105C6V Glycerol-3-phosphate dehydrogenase RA8CHR_02921 ENOG4108IJ9 (ABC) transporter RA8CHR_02924 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component RA8CHR_02929 ENOG4105CVE Lytic murein transglycosylase RA8CHR_02930 ENOG4105F8C transglutaminase domain-containing protein RA8CHR_02932 ENOG4105C7R Atpase associated with various cellular activities aaa_3 RA8CHR_02933 ENOG4105DGU Histone deacetylase RA8CHR_02934 ENOG4105EGS Mechanosensitive ion channel RA8CHR_02935 ENOG4105BZJ Electron transfer flavoprotein RA8CHR_02936 ENOG4105C10 Electron transfer flavoprotein RA8CHR_02937 ENOG4105CSU acyl-Coa dehydrogenase RA8CHR_02941 ENOG4108JJ9 ABC, transporter RA8CHR_02942 ENOG4108JJ8 (ABC) transporter RA8CHR_02943 ENOG4105C4M (Ubiquinol oxidase) subunit I RA8CHR_02944 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii RA8CHR_02946 ENOG4105BZU Histidine kinase RA8CHR_02952 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase RA8CHR_02954 ENOG4105CSH Transporter RA8CHR_02957 ENOG4107HP6 Transcriptional regulator RA8CHR_02958 ENOG4105E2X shikimate dehydrogenase RA8CHR_02960 ENOG4105E2X shikimate dehydrogenase RA8CHR_02961 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase RA8CHR_02968 ENOG4105EGI Transcriptional regulator RA8CHR_02969 ENOG4105CBP Major Facilitator RA8CHR_02972 ENOG4105CHP RNA polymerase RA8CHR_02973 ENOG4105GRZ Ycii-related protein RA8CHR_02976 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) RA8CHR_02978 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor RA8CHR_02979 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) RA8CHR_02980 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) RA8CHR_02983 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_02985 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit RA8CHR_02986 ENOG4105EXW epimerase dehydratase RA8CHR_02987 ENOG4105BZU Histidine kinase RA8CHR_02988 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase RA8CHR_02989 ENOG4105CHR reductase RA8CHR_02993 ENOG4105DHQ Histidine kinase RA8CHR_02996 ENOG4105DIJ Phosphoethanolamine transferase RA8CHR_02998 ENOG4107FQ9 ethanolamine ammonia-lyase RA8CHR_02999 ENOG4105CPD ethanolamine ammonia-lyase RA8CHR_03000 ENOG4108V1T peptidylprolyl cis-trans isomerase RA8CHR_03003 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) RA8CHR_03005 ENOG4105CF1 Alkylated DNA repair protein RA8CHR_03007 ENOG4108KX4 response regulator RA8CHR_03010 ENOG410846T CoA-transferase family III RA8CHR_03014 ENOG4105C26 Dehydrogenase RA8CHR_03016 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_03017 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8CHR_03018 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) RA8CHR_03023 ENOG4105CVJ phosphoglycerate mutase RA8CHR_03024 ENOG41061ZR Transcriptional regulator RA8CHR_03025 ENOG4106S2D Transcriptional regulator RA8CHR_03028 ENOG4107RZC phospholipase d RA8CHR_03029 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase RA8CHR_03030 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) RA8CHR_03032 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase RA8CHR_03033 ENOG4105BZ1 (ABC) transporter RA8CHR_03034 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b RA8CHR_03062 ENOG4105C0B DNA polymerase III (alpha subunit) RA8CHR_03064 ENOG4105CP9 extracellular ligand-binding receptor RA8CHR_03066 ENOG4108W9H Tetr family transcriptional regulator RA8CHR_03071 ENOG4105BZ9 Cytochrome C oxidase, subunit I RA8CHR_03072 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) RA8CHR_03075 ENOG4105NXH GreA GreB family elongation factor RA8CHR_03076 ENOG4107QZF nitrite reductase NADPH large subunit RA8CHR_03077 ENOG4105WZK nitrite reductase NADPH small subunit RA8CHR_03078 ENOG4105TMB Formate nitrite transporter RA8CHR_03079 ENOG4107QPV Serine Threonine protein kinase RA8CHR_03081 ENOG4105D82 Glutamate dehydrogenase RA8CHR_03086 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) RA8CHR_03088 ENOG4105MWK D-amino acid dehydrogenase, small subunit RA8CHR_03089 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) RA8CHR_03095 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) RA8CHR_03096 ENOG4107HP6 Transcriptional regulator RA8CHR_03098 ENOG4105C7K acetolactate synthase RA8CHR_03099 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) RA8CHR_03103 ENOG4105MSY salicylate hydroxylase RA8CHR_03107 ENOG4108Z9W Outer membrane porin RA8CHR_03114 ENOG4105MP9 class II Aldolase RA8CHR_03115 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic RA8CHR_03118 ENOG4105F8V Hydrolase, tatD family RA8CHR_03120 ENOG4107QRG dna polymerase iii RA8CHR_03121 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) RA8CHR_03122 ENOG4105HHA aminodeoxychorismate lyase RA8CHR_03123 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) RA8CHR_03124 ENOG4105VCD cytoplasmic protein RA8CHR_03125 ENOG4105D22 carbon starvation protein RA8CHR_03131 ENOG4105C0A alcohol dehydrogenase RA8CHR_03135 ENOG4105C5I Dehydrogenase RA8CHR_03137 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_03145 ENOG4105BZM domain protein RA8CHR_03149 ENOG4106KE4 Dehydrogenase RA8CHR_03151 ENOG4105EJC lysr family transcriptional regulator RA8CHR_03156 ENOG4107QJQ Mate efflux family protein RA8CHR_03161 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) RA8CHR_03165 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA8CHR_03166 ENOG4105C2C drug resistance transporter, Bcr CflA RA8CHR_03169 ENOG4105CPQ Dehydrogenase RA8CHR_03175 ENOG4105DY2 Paraquat-inducible protein b RA8CHR_03176 ENOG4105F1S paraquat-inducible protein a RA8CHR_03177 ENOG4105F1S paraquat-inducible protein a RA8CHR_03178 ENOG4105HEI LysR family (Transcriptional regulator RA8CHR_03179 ENOG4105F27 Major Facilitator RA8CHR_03180 ENOG4105CPC Aldo Keto reductase RA8CHR_03181 ENOG4105XJC Two component transcriptional regulator (Winged helix family RA8CHR_03182 ENOG4105DHQ Histidine kinase RA8CHR_03184 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) RA8CHR_03186 ENOG4105KCV RNA signal recognition particle 4.5S RNA RA8CHR_03190 ENOG4105CSU acyl-Coa dehydrogenase RA8CHR_03191 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein RA8CHR_03193 ENOG4105CHR reductase RA8CHR_03195 ENOG4105CSU acyl-Coa dehydrogenase RA8CHR_03196 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_03197 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) RA8CHR_03198 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase RA8CHR_03199 ENOG4108IV0 ABC, transporter RA8CHR_03200 ENOG4105C0Z ABC transporter RA8CHR_03202 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_03204 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_03205 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) RA8CHR_03206 ENOG4105CNG UPF0061 protein RA8CHR_03207 ENOG4105E0X reductase RA8CHR_03208 ENOG4107835 probably involved in intracellular septation (By similarity) RA8CHR_03210 ENOG4107TF3 peptidylprolyl cis-trans isomerase RA8CHR_03214 ENOG4108ETH Formylglycinamide ribotide synthetase RA8CHR_03215 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) RA8CHR_03216 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) RA8CHR_03217 ENOG4105MGM doxx family RA8CHR_03218 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) RA8CHR_03220 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) RA8CHR_03222 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) RA8CHR_03230 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) RA8CHR_03231 ENOG4108IJ6 ABC transporter RA8CHR_03232 ENOG4105ECW sulfate abc transporter RA8CHR_03233 ENOG4108I5D sulfate abc transporter RA8CHR_03234 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein RA8CHR_03236 ENOG4105JQN Transcriptional regulator RA8CHR_03237 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) RA8CHR_03241 ENOG4105D7W serine acetyltransferase RA8CHR_03242 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein RA8CHR_03243 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) RA8CHR_03244 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) RA8CHR_03247 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) RA8CHR_03249 ENOG4108UT2 hemolysin iii RA8CHR_03255 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) RA8CHR_03256 ENOG4105C11 sulfate adenylyltransferase), subunit 2 RA8CHR_03257 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) RA8CHR_03258 ENOG4108Z4U Ferredoxin RA8CHR_03259 ENOG4105CAY ferredoxin--nadp reductase RA8CHR_03260 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase RA8CHR_03262 ENOG4105W2Z cytochrome C, class I RA8CHR_03264 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) RA8CHR_03265 ENOG4108TEB UPF0114 protein RA8CHR_03267 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) RA8CHR_03268 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit RA8CHR_03270 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_03280 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) RA8CHR_03281 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) RA8CHR_03282 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) RA8CHR_03283 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation RA8CHR_03286 ENOG4105ENT Efflux transporter rnd family, mfp subunit RA8CHR_03298 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant RA8CHR_03299 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) RA8CHR_03304 ENOG4108IV0 ABC, transporter RA8CHR_03305 ENOG4105C0Z ABC transporter RA8CHR_03310 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_03326 ENOG4105CC0 LysR family Transcriptional regulator RA8CHR_03328 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_03330 ENOG4105CC9 acyl-Coa dehydrogenase RA8CHR_03332 ENOG4105CHR reductase RA8CHR_03335 ENOG4105EN6 Membrane RA8CHR_03336 ENOG4105DS0 Transcriptional regulator, Crp Fnr family RA8CHR_03342 ENOG4105DHQ Histidine kinase RA8CHR_03343 ENOG4105VEJ Heat shock protein RA8CHR_03344 ENOG4105CSR polyphosphate kinase 2 RA8CHR_03346 ENOG4107HP6 Transcriptional regulator RA8CHR_03353 ENOG4105CFH Aspartokinase RA8CHR_03354 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) RA8CHR_03355 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) RA8CHR_03357 ENOG4105C8N cysteinyl-tRNA synthetase RA8CHR_03361 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) RA8CHR_03362 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) RA8CHR_03365 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division RA8CHR_03366 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) RA8CHR_03367 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) RA8CHR_03372 ENOG4106855 Competence protein RA8CHR_03373 ENOG4106855 Competence protein RA8CHR_03374 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) RA8CHR_03375 ENOG4108R6K riboflavin synthase, subunit alpha RA8CHR_03376 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) RA8CHR_03377 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) RA8CHR_03378 ENOG4107YIM Involved in the transcription termination process (By similarity) RA8CHR_03379 ENOG4105CHM Aminotransferase RA8CHR_03380 ENOG4107YD3 Thioesterase RA8CHR_03381 ENOG4105E02 MotA TolQ exbB proton channel RA8CHR_03382 ENOG4108ZZF transport protein (ExbD) RA8CHR_03384 ENOG4105C0B DNA polymerase III (alpha subunit) RA8CHR_03385 ENOG4105C72 UPF0176 protein RA8CHR_03386 ENOG4105EUB pirin domain protein RA8CHR_03388 ENOG4108VBZ doxx family RA8CHR_03392 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) RA8CHR_03393 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) RA8CHR_03396 ENOG4105FDF Could be involved in DNA repair (By similarity) RA8CHR_03399 ENOG4105DV0 amidase (EC 3.5.1.4 RA8CHR_03402 ENOG4105MP9 class II Aldolase RA8CHR_03408 ENOG4105CBG Sulfatase RA8CHR_03409 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_03410 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_03411 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_03416 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A RA8CHR_03417 ENOG4108Z6B deaminase RA8CHR_03422 ENOG4108ZXC Two component transcriptional regulator, luxr family RA8CHR_03423 ENOG4105BZU Histidine kinase RA8CHR_03424 ENOG4107QK4 glycoside hydrolase, family 3 domain protein RA8CHR_03427 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr RA8CHR_03428 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme RA8CHR_03429 ENOG4108IV0 ABC, transporter RA8CHR_03430 ENOG4105C0Z ABC transporter RA8CHR_03432 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_03434 ENOG4105CHR reductase RA8CHR_03436 ENOG4105EBR Carboxylesterase RA8CHR_03438 ENOG4105EQ2 LysR family Transcriptional regulator RA8CHR_03439 ENOG4105CD5 CoA-binding domain protein RA8CHR_03440 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_03443 ENOG4105CSH Transporter RA8CHR_03444 ENOG4105E2S oxidase) subunit II RA8CHR_03445 ENOG4105BZ9 Cytochrome C oxidase, subunit I RA8CHR_03446 ENOG4105CCU oxidase (Subunit III) RA8CHR_03447 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) RA8CHR_03449 ENOG4105TX3 Histidine kinase RA8CHR_03450 ENOG4108UYB regulatoR RA8CHR_03451 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) RA8CHR_03454 ENOG4107SM8 Adenylate Guanylate cyclase RA8CHR_03456 ENOG410846T CoA-transferase family III RA8CHR_03457 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_03459 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) RA8CHR_03460 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) RA8CHR_03463 ENOG4108Z1B Cyclase dehydrase RA8CHR_03464 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) RA8CHR_03471 ENOG4105CI3 gtp-binding protein typa RA8CHR_03472 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) RA8CHR_03473 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) RA8CHR_03475 ENOG4105CHV Transcription elongation factor NusA RA8CHR_03476 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) RA8CHR_03477 ENOG4105CBP Major Facilitator RA8CHR_03478 ENOG4108JQ5 ABC transporter RA8CHR_03479 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component RA8CHR_03480 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component RA8CHR_03481 ENOG4105E43 Extracellular solute-binding protein, family 5 RA8CHR_03482 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH RA8CHR_03485 ENOG4105CXN decarboxylase RA8CHR_03491 ENOG4105CP9 extracellular ligand-binding receptor RA8CHR_03494 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) RA8CHR_03498 ENOG4107R11 Transcriptional regulator RA8CHR_03499 ENOG4105CHM Aminotransferase RA8CHR_03501 ENOG4105CQ7 ATP-dependent helicase RA8CHR_03502 ENOG4108EKC n-acetylglutamate synthase RA8CHR_03503 ENOG4105CHM Aminotransferase RA8CHR_03504 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) RA8CHR_03505 ENOG4105CZX twitching motility protein RA8CHR_03506 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) RA8CHR_03507 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) RA8CHR_03508 ENOG4105C5H ABC transporter RA8CHR_03514 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein RA8CHR_03515 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) RA8CHR_03517 ENOG4105E2X shikimate dehydrogenase RA8CHR_03520 ENOG4107EFR Flavocytochrome c RA8CHR_03521 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_03528 ENOG4105CHR reductase RA8CHR_03530 ENOG4105CHR reductase RA8CHR_03532 ENOG4105C0Z ABC transporter RA8CHR_03533 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_03535 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_03536 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein RA8CHR_03542 ENOG4108FUF Transcriptional regulator, IclR family RA8CHR_03544 ENOG4105D7T ABC transporter RA8CHR_03545 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_03547 ENOG4107QSA Oxaloacetate decarboxylase RA8CHR_03548 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase RA8CHR_03551 ENOG4105CHR reductase RA8CHR_03554 ENOG4105CUZ uba thif-type nad fad binding protein RA8CHR_03556 ENOG4105KCK Peptidoglycan-associated lipoprotein RA8CHR_03557 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) RA8CHR_03558 ENOG4105BZ1 (ABC) transporter RA8CHR_03560 ENOG4105C03 ribonuclease RA8CHR_03561 ENOG4108Z03 MAF-like protein RA8CHR_03562 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) RA8CHR_03563 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) RA8CHR_03564 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) RA8CHR_03565 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) RA8CHR_03566 ENOG4105C12 Phosphoribosylglycinamide synthetase RA8CHR_03567 ENOG4105CDY transcriptional regulatory protein RA8CHR_03572 ENOG4105C2D reductase RA8CHR_03575 ENOG4108ZJ4 polysaccharide deacetylase RA8CHR_03579 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) RA8CHR_03582 ENOG4105D7A ATP-binding protein RA8CHR_03583 ENOG4108ZJD Protein of unknown function (DUF1109) RA8CHR_03584 ENOG4105NCT RNA Polymerase RA8CHR_03586 ENOG4105E18 UPF0276 protein RA8CHR_03591 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) RA8CHR_03592 ENOG4107TFB basic membrane RA8CHR_03593 ENOG4108JQ9 ABC transporter RA8CHR_03594 ENOG4105UIB (ABC) transporter RA8CHR_03596 ENOG4105DZC cytosine deaminase RA8CHR_03597 ENOG4105CJB Exodeoxyribonuclease I RA8CHR_03598 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) RA8CHR_03599 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit RA8CHR_03600 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) RA8CHR_03604 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) RA8CHR_03605 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA8CHR_03607 ENOG4108ZZF transport protein (ExbD) RA8CHR_03608 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) RA8CHR_03609 ENOG4105W49 UPF0434 protein RA8CHR_03610 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) RA8CHR_03611 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) RA8CHR_03614 ENOG4107RB3 L-asparaginase RA8CHR_03615 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) RA8CHR_03617 ENOG4108JQ1 Dehydrogenase RA8CHR_03618 ENOG4105F27 Major Facilitator RA8CHR_03620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase RA8CHR_03621 ENOG4108UKI Enoyl-CoA hydratase RA8CHR_03626 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) RA8CHR_03628 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) RA8CHR_03629 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) RA8CHR_03630 ENOG4105HBR Rna-binding protein RA8CHR_03633 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) RA8CHR_03635 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain RA8CHR_03638 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) RA8CHR_03639 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) RA8CHR_03640 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) RA8CHR_03641 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) RA8CHR_03642 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) RA8CHR_03644 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane RA8CHR_03645 ENOG4105DZP Membrane-associated zinc metalloprotease RA8CHR_03646 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) RA8CHR_03647 ENOG4105KNE Phosphatidate cytidylyltransferase RA8CHR_03648 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) RA8CHR_03649 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) RA8CHR_03650 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) RA8CHR_03651 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) RA8CHR_03652 ENOG4105CE9 30S ribosomal protein S2 RA8CHR_03654 ENOG4105MWK D-amino acid dehydrogenase, small subunit RA8CHR_03655 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) RA8CHR_03656 ENOG41061TZ Short-chain dehydrogenase reductase Sdr RA8CHR_03657 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) RA8CHR_03659 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) RA8CHR_03660 ENOG4108NVM synthesis repressor PhaR RA8CHR_03663 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) RA8CHR_03664 ENOG4105DTD Dehydrogenase RA8CHR_03668 ENOG4105E0F Histidine kinase RA8CHR_03669 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) RA8CHR_03670 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) RA8CHR_03671 ENOG4108JA2 transcriptioN-repair coupling factor RA8CHR_03672 ENOG4105EAC phosphoserine phosphatase RA8CHR_03677 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_03678 ENOG4105CSM endonuclease III RA8CHR_03679 ENOG4108PGP mmge prpd family protein RA8CHR_03681 ENOG4108UKI Enoyl-CoA hydratase RA8CHR_03685 ENOG4108YIQ Alpha beta hydrolase RA8CHR_03687 ENOG4105GAK amidohydrolase 2 RA8CHR_03688 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr RA8CHR_03693 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) RA8CHR_03694 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) RA8CHR_03695 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) RA8CHR_03699 ENOG4105C1P efflux transporter, rnd family, mfp subunit RA8CHR_03702 ENOG4105CIH Imidazole acetol-phosphate transaminase RA8CHR_03703 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) RA8CHR_03704 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase RA8CHR_03705 ENOG4105E0A ABC, transporter RA8CHR_03706 ENOG4105EHG Permease protein RA8CHR_03708 ENOG4108YZT Adenosylcobinamide kinase RA8CHR_03709 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) RA8CHR_03713 ENOG4105HF0 Membrane RA8CHR_03716 ENOG4105ES4 Nitrilase RA8CHR_03718 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_03722 ENOG4105DRR Transcriptional regulator, GntR family RA8CHR_03724 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) RA8CHR_03725 ENOG4106NZI LysR family Transcriptional regulator RA8CHR_03726 ENOG4105C01 Dihydroxy-acid dehydratase RA8CHR_03731 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) RA8CHR_03732 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) RA8CHR_03736 ENOG4105EUR Domain-Containing protein RA8CHR_03739 ENOG4105DQE DNA ligase RA8CHR_03749 ENOG4105C0H protease RA8CHR_03750 ENOG4105DHQ Histidine kinase RA8CHR_03751 ENOG4105XJC Two component transcriptional regulator (Winged helix family RA8CHR_03752 ENOG4107HP6 Transcriptional regulator RA8CHR_03753 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase RA8CHR_03755 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) RA8CHR_03756 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate RA8CHR_03757 ENOG41069M3 Transcriptional regulator RA8CHR_03758 ENOG41061WM D-Alanyl-D-Alanine RA8CHR_03759 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) RA8CHR_03760 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) RA8CHR_03761 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase RA8CHR_03762 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase RA8CHR_03763 ENOG4108ZP8 Acetolactate synthase small subunit RA8CHR_03764 ENOG4105C7K acetolactate synthase RA8CHR_03769 ENOG41080IJ Diacylglycerol kinase RA8CHR_03770 ENOG4108URH decarboxylase RA8CHR_03771 ENOG4108YZA Nitrogen regulatory protein pii RA8CHR_03772 ENOG4105FDR Membrane RA8CHR_03774 ENOG4105CHR reductase RA8CHR_03775 ENOG4105CPQ Dehydrogenase RA8CHR_03776 ENOG4105F0N pyrophosphate phospho-hydrolase RA8CHR_03784 ENOG4107RZC phospholipase d RA8CHR_03788 ENOG4108JQ1 Dehydrogenase RA8CHR_03791 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_03796 ENOG4105MP9 class II Aldolase RA8CHR_03797 ENOG4105FP9 thiamine pyrophosphate RA8CHR_03798 ENOG4105C26 Dehydrogenase RA8CHR_03802 ENOG4108UKV benzoate 1,2-dioxygenase RA8CHR_03836 ENOG4108JUA Transcriptional regulator RA8CHR_03837 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) RA8CHR_03838 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) RA8CHR_03839 ENOG4105CVM Molybdenum cofactor synthesis domain protein RA8CHR_03841 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) RA8CHR_03843 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) RA8CHR_03844 ENOG4105E9H Lytic Murein transglycosylase RA8CHR_03845 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component RA8CHR_03847 ENOG4105D2X ABC transporter substrate-binding protein RA8CHR_03849 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) RA8CHR_03850 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) RA8CHR_03851 ENOG4107QMP dna polymerase iii subunits gamma and tau RA8CHR_03855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase RA8CHR_03856 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation RA8CHR_03857 ENOG4105K63 Thioredoxin RA8CHR_03858 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) RA8CHR_03859 ENOG4105D9R oxidoreductase RA8CHR_03860 ENOG4105NRA 50s ribosomal protein l31 type b RA8CHR_03862 ENOG4107QI1 Mate efflux family protein RA8CHR_03863 ENOG4105BZU Histidine kinase RA8CHR_03864 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_03866 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) RA8CHR_03867 ENOG4105E2Z phosphate ABC transporter (Permease RA8CHR_03868 ENOG4105C8U phosphate abc transporter RA8CHR_03869 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) RA8CHR_03870 ENOG4105C9X ppx gppa phosphatase RA8CHR_03874 ENOG4108JU3 Alkyl hydroperoxide reductase RA8CHR_03875 ENOG4105CYM Glutathione S-transferase RA8CHR_03880 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_03881 ENOG4108M9J MaoC like domain protein RA8CHR_03883 ENOG4108QG2 Membrane RA8CHR_03886 ENOG41060WC Enoyl-CoA hydratase RA8CHR_03888 ENOG4105K6S Short-chain dehydrogenase reductase Sdr RA8CHR_03889 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F RA8CHR_03894 ENOG4107YZX Universal stress protein RA8CHR_03896 ENOG4105CCT upf0313 protein RA8CHR_03897 ENOG410645S MarR family Transcriptional regulator RA8CHR_03902 ENOG4107S2Z UPF0761 membrane protein RA8CHR_03905 ENOG4105CPC Aldo Keto reductase RA8CHR_03910 ENOG4105C2N RNA methyltransferase TrmH family group 3 RA8CHR_03911 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) RA8CHR_03912 ENOG4108UJV acyl-CoA thioesterase i RA8CHR_03914 ENOG4105C28 cystathionine RA8CHR_03917 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis RA8CHR_03918 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) RA8CHR_03920 ENOG4105EPW hflc protein RA8CHR_03921 ENOG4107QJR hflk protein RA8CHR_03922 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) RA8CHR_03923 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) RA8CHR_03924 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) RA8CHR_03925 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) RA8CHR_03927 ENOG4105CUT histidyl-tRNA synthetase RA8CHR_03928 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) RA8CHR_03931 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs RA8CHR_03932 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) RA8CHR_03933 ENOG4105FE9 pseudouridine synthase RA8CHR_03934 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) RA8CHR_03935 ENOG4105C34 Pseudouridine synthase RA8CHR_03936 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane RA8CHR_03937 ENOG4105DVT helicase RA8CHR_03941 ENOG4105D6Z AFG1 family ATPase RA8CHR_03942 ENOG4107QN2 dihydrolipoyl dehydrogenase RA8CHR_03943 ENOG4105C7S Dehydrogenase RA8CHR_03944 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 RA8CHR_03946 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) RA8CHR_03947 ENOG4105DUM transcriptional regulator, lysR family RA8CHR_03949 ENOG4105C26 Dehydrogenase RA8CHR_03954 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) RA8CHR_03955 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase RA8CHR_03956 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase RA8CHR_03958 ENOG4105CSH Transporter RA8CHR_03962 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_03963 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_03964 ENOG4105BZU Histidine kinase RA8CHR_03965 ENOG4108ZXC Two component transcriptional regulator, luxr family RA8CHR_03966 ENOG4105BZU Histidine kinase RA8CHR_03967 ENOG4105D58 Diguanylate phosphodiesterase RA8CHR_03969 ENOG4105CMM transposase RA8CHR_03976 ENOG4108JQ7 (ABC) transporter RA8CHR_03978 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA8CHR_03979 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component RA8CHR_03985 ENOG4108TN6 type iii secretion RA8CHR_03987 ENOG4108JIR Flagellum-specific ATP synthase RA8CHR_03990 ENOG4107Y59 type iii secretion RA8CHR_03999 ENOG4105CB2 alcohol dehydrogenase RA8CHR_04002 ENOG4105F27 Major Facilitator RA8CHR_04007 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_04009 ENOG4108YYH Nadph-dependent fmn reductase RA8CHR_04016 ENOG4107Z7P Ferredoxin RA8CHR_04018 ENOG4105CAD extracellular ligand-binding receptor RA8CHR_04021 ENOG4105C0Z ABC transporter RA8CHR_04022 ENOG4108IV0 ABC, transporter RA8CHR_04025 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_04026 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_04028 ENOG4105FDP GntR family transcriptional regulator RA8CHR_04037 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_04038 ENOG4108WYP Transcriptional regulator RA8CHR_04040 ENOG4108IY8 ABC, transporter RA8CHR_04041 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_04043 ENOG41082A2 Alpha beta hydrolase RA8CHR_04046 ENOG4105ER2 Ompa motb domain protein RA8CHR_04050 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) RA8CHR_04051 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) RA8CHR_04053 ENOG4105D8V Glucose sorbosone dehydrogenase RA8CHR_04054 ENOG4105K4H Nlp p60 protein RA8CHR_04055 ENOG4107QN2 dihydrolipoyl dehydrogenase RA8CHR_04056 ENOG4107QSN dihydrolipoamide acetyltransferase RA8CHR_04057 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) RA8CHR_04058 ENOG4105BZU Histidine kinase RA8CHR_04059 ENOG4108ZXC Two component transcriptional regulator, luxr family RA8CHR_04060 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) RA8CHR_04061 ENOG4105DGW oligopeptidase A RA8CHR_04063 ENOG4105E66 phosphoriboisomerase A RA8CHR_04064 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) RA8CHR_04067 ENOG4105D5U fad dependent oxidoreductase RA8CHR_04070 ENOG4107RZZ dna polymerase iii epsilon subunit RA8CHR_04071 ENOG4108ZIT Ferredoxin, 2FE-2S RA8CHR_04072 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB RA8CHR_04075 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins RA8CHR_04076 ENOG4105C3J Cysteine desulfurase RA8CHR_04077 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family RA8CHR_04079 ENOG4105CGF Aromatic amino acid aminotransferase RA8CHR_04081 ENOG4108R3D Electron transport complex RA8CHR_04087 ENOG4105DJT lAO AO transport system ATPase RA8CHR_04089 ENOG4105DRR Transcriptional regulator, GntR family RA8CHR_04093 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) RA8CHR_04094 ENOG4107QRT dEAD DEAH box helicase RA8CHR_04095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_04103 ENOG4105CKD glutathione-regulated potassium-efflux system protein RA8CHR_04104 ENOG4105CHR reductase RA8CHR_04106 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_04107 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class RA8CHR_04109 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase RA8CHR_04113 ENOG4108RH0 Crea protein RA8CHR_04115 ENOG4108K5P (LipO)protein RA8CHR_04116 ENOG4107RZC phospholipase d RA8CHR_04119 ENOG4105F04 LysR family Transcriptional regulator RA8CHR_04120 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) RA8CHR_04128 ENOG4107RSM transcriptional regulator RA8CHR_04129 ENOG4105CHR reductase RA8CHR_04131 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_04132 ENOG4108IV0 ABC, transporter RA8CHR_04133 ENOG4105C0Z ABC transporter RA8CHR_04138 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase RA8CHR_04146 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) RA8CHR_04153 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_04154 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_04158 ENOG4105BZU Histidine kinase RA8CHR_04160 ENOG4105EQ2 LysR family Transcriptional regulator RA8CHR_04167 ENOG41061N2 exported protein RA8CHR_04168 ENOG4105R1U AraC Family Transcriptional Regulator RA8CHR_04169 ENOG4105DJ2 Major Facilitator Superfamily RA8CHR_04170 ENOG4108K3A Glutathione S-transferase RA8CHR_04173 ENOG4105EUB pirin domain protein RA8CHR_04179 ENOG4108K3A Glutathione S-transferase RA8CHR_04180 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase RA8CHR_04180 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase RA8CHR_04185 ENOG4108YYC ycei family RA8CHR_04186 ENOG4108ZHJ Organic hydroperoxide resistance protein RA8CHR_04187 ENOG4105CH6 catalase RA8CHR_04188 ENOG4105HEI LysR family (Transcriptional regulator RA8CHR_04189 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr RA8CHR_04191 ENOG4105EXC Acyl-transferase RA8CHR_04196 ENOG4105CSU acyl-Coa dehydrogenase RA8CHR_04208 ENOG4108UAU isochorismatase RA8CHR_04210 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_04212 ENOG4105C0Z ABC transporter RA8CHR_04213 ENOG4108IV0 ABC, transporter RA8CHR_04214 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_04219 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_04220 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_04223 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_04226 ENOG4105CHR reductase RA8CHR_04227 ENOG4105R1U AraC Family Transcriptional Regulator RA8CHR_04228 ENOG4105DSW Fusaric acid resistance protein RA8CHR_04230 ENOG4105Y49 secretion protein, HlyD family RA8CHR_04237 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_04239 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_04240 ENOG4105CC9 acyl-Coa dehydrogenase RA8CHR_04241 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr RA8CHR_04248 ENOG4107258 Transcriptional regulator RA8CHR_04255 ENOG4108UAU isochorismatase RA8CHR_04261 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_04263 ENOG4105DND Transcriptional regulator RA8CHR_04270 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) RA8CHR_04272 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) RA8CHR_04273 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) RA8CHR_04274 ENOG4105VJV 50s ribosomal protein L35 RA8CHR_04275 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) RA8CHR_04276 ENOG4105C22 threonyL-tRNA synthetase RA8CHR_04279 ENOG4108I9X Isocitrate lyase RA8CHR_04284 ENOG4108W9H Tetr family transcriptional regulator RA8CHR_04293 ENOG4107TTA Xylose isomerase domain protein TIM barrel RA8CHR_04297 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) RA8CHR_04303 ENOG4105CHH sulfate transporter RA8CHR_04304 ENOG4108YZN class I peptide chain release factor RA8CHR_04307 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit RA8CHR_04311 ENOG4106NZI LysR family Transcriptional regulator RA8CHR_04313 ENOG4108ZAF Molybdopterin RA8CHR_04314 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) RA8CHR_04315 ENOG4105M00 molybdopterin converting factor, subunit 1 RA8CHR_04316 ENOG4105CVM Molybdenum cofactor synthesis domain protein RA8CHR_04317 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b RA8CHR_04318 ENOG4105D98 threonine synthase RA8CHR_04319 ENOG4105D6E homoserine dehydrogenase RA8CHR_04320 ENOG4105CHM Aminotransferase RA8CHR_04322 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen RA8CHR_04323 ENOG4108IAB Phoh family RA8CHR_04326 ENOG4105CDU Replicative dna helicase RA8CHR_04327 ENOG4105K9Q Binds to the 23S rRNA (By similarity) RA8CHR_04328 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) RA8CHR_04330 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) RA8CHR_04332 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) RA8CHR_04333 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) RA8CHR_04334 ENOG4108JU3 Alkyl hydroperoxide reductase RA8CHR_04335 ENOG4105D3R alkyl hydroperoxide reductase RA8CHR_04336 ENOG4108UQY Iron-storage protein RA8CHR_04337 ENOG4105HB4 Pathways of utilization of iron bound to transferrin, lactoferrin and hemoglobin but not to haemin or citrate where dependent on the TonB system RA8CHR_04339 ENOG4105M8F Biopolymer transport protein exbD tolR RA8CHR_04341 ENOG4108ZJF Glcg protein RA8CHR_04342 ENOG4108MN8 Membrane RA8CHR_04343 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) RA8CHR_04344 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA8CHR_04345 ENOG4108K5P (LipO)protein RA8CHR_04346 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) RA8CHR_04347 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) RA8CHR_04351 ENOG4107TF3 peptidylprolyl cis-trans isomerase RA8CHR_04354 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) RA8CHR_04355 ENOG4105EBM Alpha Beta Hydrolase Fold protein RA8CHR_04356 ENOG4105EJC lysr family transcriptional regulator RA8CHR_04367 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) RA8CHR_04369 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) RA8CHR_04373 ENOG4105C5I Dehydrogenase RA8CHR_04375 ENOG4107RH7 Nicotinate phosphoribosyltransferase RA8CHR_04376 ENOG4105VDW Csbd family RA8CHR_04379 ENOG4105DGU Histone deacetylase RA8CHR_04380 ENOG4108WFY phasin family RA8CHR_04382 ENOG4107S2Z UPF0761 membrane protein RA8CHR_04383 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) RA8CHR_04384 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA8CHR_04385 ENOG4105C2C drug resistance transporter, Bcr CflA RA8CHR_04388 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_04389 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase RA8CHR_04391 ENOG4105EJC lysr family transcriptional regulator RA8CHR_04392 ENOG4108RYK Nad-dependent epimerase dehydratase RA8CHR_04395 ENOG4108IV0 ABC, transporter RA8CHR_04396 ENOG4105C0Z ABC transporter RA8CHR_04401 ENOG4108WYP Transcriptional regulator RA8CHR_04405 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) RA8CHR_04408 ENOG4105E90 ABC transporter RA8CHR_04409 ENOG4105C26 Dehydrogenase RA8CHR_04410 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase RA8CHR_04412 ENOG4107YCY Transcriptional regulator RA8CHR_04413 ENOG4105E9Z Nad-dependent epimerase dehydratase RA8CHR_04415 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit RA8CHR_04417 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_04418 ENOG4105CTX dehydratase RA8CHR_04421 ENOG4105DJ4 phosphatidylserine decarboxylase RA8CHR_04423 ENOG4108V1T peptidylprolyl cis-trans isomerase RA8CHR_04424 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ RA8CHR_04425 ENOG4105CFG Acts as a chaperone (By similarity) RA8CHR_04426 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) RA8CHR_04427 ENOG41073TP transcriptional regulator RA8CHR_04428 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_04430 ENOG4105CYN Serine protein kinase RA8CHR_04431 ENOG4106AKX UPF0229 protein RA8CHR_04432 ENOG4105ED1 spovr family RA8CHR_04433 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_04439 ENOG4108R3E Dna-3-methyladenine glycosylase i RA8CHR_04440 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) RA8CHR_04441 ENOG4105ETE Transcriptional regulator (LacI family RA8CHR_04443 ENOG4107YCY Transcriptional regulator RA8CHR_04448 ENOG4107QPD alcohol dehydrogenase RA8CHR_04454 ENOG4107QX3 carboxylase RA8CHR_04455 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family RA8CHR_04458 ENOG4105ENJ RND efflux system, outer membrane lipoprotein RA8CHR_04462 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) RA8CHR_04464 ENOG4107RZC phospholipase d RA8CHR_04467 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) RA8CHR_04468 ENOG4105K4T epimerase RA8CHR_04469 ENOG4105K63 Thioredoxin RA8CHR_04470 ENOG4107S2Z UPF0761 membrane protein RA8CHR_04472 ENOG4105CQB FAD linked oxidase domain protein RA8CHR_04473 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) RA8CHR_04478 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) RA8CHR_04480 ENOG4105CMM transposase RA8CHR_04485 ENOG4105CFF transcriptional regulator RA8CHR_04487 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) RA8CHR_04490 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) RA8CHR_04499 ENOG4105CGK Exodeoxyribonuclease III RA8CHR_04501 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family RA8CHR_04502 ENOG4105CUX Signal transduction histidine kinase RA8CHR_04505 ENOG4107TH8 cina domain protein RA8CHR_04510 ENOG4105I08 Pseudouridine synthase RA8CHR_04512 ENOG4106R49 Methyltransferase RA8CHR_04516 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) RA8CHR_04517 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) RA8CHR_04518 ENOG4105UYK outer membrane protein a RA8CHR_04519 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA8CHR_04521 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) RA8CHR_04522 ENOG4105CQC Prephenate dehydratase RA8CHR_04524 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase RA8CHR_04525 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) RA8CHR_04528 ENOG4105CFV Tetratricopeptide repeat protein RA8CHR_04532 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_04533 ENOG4107Z6W Protein CrcB homolog RA8CHR_04534 ENOG4105D65 subunit l RA8CHR_04535 ENOG4108ZE9 Monovalent cation H antiporter subunit C RA8CHR_04536 ENOG4107R4Z monovalent cation h antiporter subunit d RA8CHR_04538 ENOG4105W4C monovalent cation H antiporter subunit F RA8CHR_04539 ENOG4105KJM monovalent cation h antiporter subunit g RA8CHR_04549 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) RA8CHR_04556 ENOG4108YYC ycei family RA8CHR_04559 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family RA8CHR_04562 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) RA8CHR_04568 ENOG4108IJ0 Aspartate ammonia-lyase RA8CHR_04572 ENOG4105F4R Transcriptional regulator mode RA8CHR_04573 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein RA8CHR_04574 ENOG4105E0C molybdate abc transporter RA8CHR_04575 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) RA8CHR_04577 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) RA8CHR_04578 ENOG4105MWK D-amino acid dehydrogenase, small subunit RA8CHR_04583 ENOG4105F4R Transcriptional regulator mode RA8CHR_04587 ENOG4108IV0 ABC, transporter RA8CHR_04588 ENOG4105C0Z ABC transporter RA8CHR_04591 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) RA8CHR_04592 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit RA8CHR_04593 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit RA8CHR_04594 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit RA8CHR_04595 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit RA8CHR_04597 ENOG4108ZJI phenylacetic acid degradation protein RA8CHR_04598 ENOG4108UKI Enoyl-CoA hydratase RA8CHR_04599 ENOG4108Z0R Transferase RA8CHR_04600 ENOG4108IG5 Transcriptional regulator RA8CHR_04601 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process RA8CHR_04603 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8CHR_04605 ENOG4105CH5 extracellular solute-binding protein, family 7 RA8CHR_04606 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) RA8CHR_04608 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA8CHR_04611 ENOG4105KHC sulfurtransferase RA8CHR_04613 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) RA8CHR_04616 ENOG4105WKW Pfam:DUF1458 RA8CHR_04619 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) RA8CHR_04621 ENOG4107RP9 extracellular solute-binding protein, family 3 RA8CHR_04622 ENOG4105MWK D-amino acid dehydrogenase, small subunit RA8CHR_04625 ENOG4105C2M dna polymerase I RA8CHR_04627 ENOG4105CUV Homoserine Kinase RA8CHR_04629 ENOG4105C4R Atp-dependent dna helicase RA8CHR_04632 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) RA8CHR_04635 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_04638 ENOG4105C1J atp-dependent rna helicase RA8CHR_04639 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) RA8CHR_04640 ENOG4105D0M Protease HtpX homolog RA8CHR_04641 ENOG41090A4 Pterin carbinolamine dehydratase RA8CHR_04642 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) RA8CHR_04643 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) RA8CHR_04644 ENOG4105CIH Imidazole acetol-phosphate transaminase RA8CHR_04645 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) RA8CHR_04647 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) RA8CHR_04648 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) RA8CHR_04649 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) RA8CHR_04650 ENOG4105K5M 30s ribosomal protein S16 RA8CHR_04653 ENOG4107QXV Phosphate transporter RA8CHR_04654 ENOG4107GRR phosphate transport regulator RA8CHR_04655 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase RA8CHR_04656 ENOG4105DJ0 Poly(A) Polymerase RA8CHR_04657 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) RA8CHR_04658 ENOG4105CXB phosphoribosylaminoimidazole synthetase RA8CHR_04659 ENOG4106F5Q Membrane RA8CHR_04662 ENOG4105E2K Glycosyl transferase (Group 1 RA8CHR_04666 ENOG4105CJR Integral membrane protein (MviN RA8CHR_04667 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) RA8CHR_04669 ENOG4105C8Y Acetylornithine aminotransferase RA8CHR_04670 ENOG4105DBV ornithine carbamoyltransferase RA8CHR_04671 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) RA8CHR_04673 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) RA8CHR_04682 ENOG4105MSY salicylate hydroxylase RA8CHR_04684 ENOG4105CE1 Ferrous iron transport protein b RA8CHR_04688 ENOG4107QM5 aconitate hydratase RA8CHR_04691 ENOG4107QIJ Aconitate hydratase 2 RA8CHR_04694 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) RA8CHR_04695 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) RA8CHR_04696 ENOG4105FDP GntR family transcriptional regulator RA8CHR_04699 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) RA8CHR_04700 ENOG4105E33 succinate dehydrogenase RA8CHR_04701 ENOG41060IS Flavinator of succinate dehydrogenase RA8CHR_04702 ENOG4105BZN citrate synthase RA8CHR_04705 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_04706 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_04707 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) RA8CHR_04708 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) RA8CHR_04710 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) RA8CHR_04711 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase RA8CHR_04712 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) RA8CHR_04713 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) RA8CHR_04714 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) RA8CHR_04715 ENOG4108VIA integral membrane protein RA8CHR_04717 ENOG4105CRK lysyL-tRNA synthetase RA8CHR_04718 ENOG4105R8A Heat shock protein RA8CHR_04719 ENOG4108VKG metal-dependent hydrolase RA8CHR_04720 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) RA8CHR_04721 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) RA8CHR_04722 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) RA8CHR_04723 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) RA8CHR_04724 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) RA8CHR_04725 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) RA8CHR_04727 ENOG4105C3F Signal peptidase i RA8CHR_04728 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) RA8CHR_04729 ENOG4105C0H protease RA8CHR_04732 ENOG4105EMN RNA polymerase sigma factor RA8CHR_04733 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) RA8CHR_04734 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) RA8CHR_04735 ENOG4105CHR reductase RA8CHR_04736 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase RA8CHR_04737 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) RA8CHR_04738 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) RA8CHR_04739 ENOG4105VGS 50s ribosomal protein l32 RA8CHR_04740 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein RA8CHR_04741 ENOG4108UHJ MAF-like protein RA8CHR_04742 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) RA8CHR_04743 ENOG4106UW1 Major Facilitator superfamily RA8CHR_04744 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) RA8CHR_04747 ENOG4105EI2 Pseudouridine synthase RA8CHR_04748 ENOG4105C03 ribonuclease RA8CHR_04749 ENOG4105D3Q Sugar transferase RA8CHR_04750 ENOG4105CJT Mannose-1-phosphate guanylyltransferase RA8CHR_04751 ENOG4105C30 Nad-dependent epimerase dehydratase RA8CHR_04755 ENOG4106CD9 glycosyl transferase group 1 RA8CHR_04762 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) RA8CHR_04763 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) RA8CHR_04764 ENOG410642W LysR family Transcriptional regulator RA8CHR_04765 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) RA8CHR_04773 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) RA8CHR_04776 ENOG4105D1Q UPF0246 protein RA8CHR_04778 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase RA8CHR_04780 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) RA8CHR_04782 ENOG4105C6T cysteine synthase RA8CHR_04784 ENOG4105VFU Rna-binding protein RA8CHR_04786 ENOG4105C26 Dehydrogenase RA8CHR_04789 ENOG4108UAJ Transcriptional regulator RA8CHR_04790 ENOG4105C0H protease RA8CHR_04795 ENOG4108IV0 ABC, transporter RA8CHR_04796 ENOG4105C0Z ABC transporter RA8CHR_04797 ENOG4105CF8 branched-chain amino acid ABC transporter, permease RA8CHR_04798 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_04799 ENOG4105D1H recombination factor protein RarA RA8CHR_04800 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) RA8CHR_04801 ENOG4105CNU cell division protein FtsK RA8CHR_04803 ENOG4105C3M thioredoxin reductase RA8CHR_04804 ENOG4105KDC 50s ribosomal protein l28 RA8CHR_04805 ENOG4105W0E 50S ribosomal protein L33 RA8CHR_04811 ENOG4108V3E phosphoribosylglycinamide formyltransferase RA8CHR_04812 ENOG4105X7H acyl-CoA dehydrogenase RA8CHR_04813 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_04815 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_04817 ENOG4105DTN riboflavin biosynthesis protein ribF RA8CHR_04819 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) RA8CHR_04820 ENOG4105EAM Na Pi-cotransporter RA8CHR_04821 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein RA8CHR_04824 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) RA8CHR_04825 ENOG4108JQ7 (ABC) transporter RA8CHR_04828 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) RA8CHR_04829 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein RA8CHR_04830 ENOG4105JQN Transcriptional regulator RA8CHR_04832 ENOG4105CHR reductase RA8CHR_04834 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) RA8CHR_04838 ENOG4107QHF type ii secretion system protein e RA8CHR_04839 ENOG4105I7M spermidine synthase RA8CHR_04842 ENOG4105EYA deoxyribonuclease RA8CHR_04843 ENOG4105C0H protease RA8CHR_04844 ENOG4105C7R Atpase associated with various cellular activities aaa_3 RA8CHR_04848 ENOG4105RQF LysR family Transcriptional regulator RA8CHR_04850 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) RA8CHR_04855 ENOG4105CAF HipA N-terminal domain protein RA8CHR_04857 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) RA8CHR_04860 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) RA8CHR_04864 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase RA8CHR_04865 ENOG4105BZU Histidine kinase RA8CHR_04866 ENOG4108YZ9 Urea amidohydrolase subunit gamma RA8CHR_04868 ENOG4105KI2 Urea amidohydrolase subunit beta RA8CHR_04869 ENOG4105CQM Urea amidohydrolase subunit alpha RA8CHR_04871 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) RA8CHR_04872 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) RA8CHR_04873 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) RA8CHR_04875 ENOG4105C7K acetolactate synthase RA8CHR_04884 ENOG4105CSA Coproporphyrinogen iii oxidase RA8CHR_04885 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) RA8CHR_04886 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) RA8CHR_04888 ENOG4105D9P serine threonine protein kinase RA8CHR_04889 ENOG4105DSJ YicC domain protein RA8CHR_04890 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) RA8CHR_04891 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) RA8CHR_04892 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) RA8CHR_04893 ENOG4108RRZ Transcription elongation factor GreB RA8CHR_04930 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) RA8CHR_04945 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) RA8CHR_04949 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8CHR_04958 ENOG4105CDA abc transporter atp-binding protein RA8CHR_04960 ENOG4105DRP amino acid AbC transporter RA8CHR_04961 ENOG4105EAD ABC transporter RA8CHR_05035 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) RA8CHR_05042 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) RA8CHR_05046 ENOG4105ECI YeeC-like protein RA8CHR_05047 ENOG4105F6A helicase RA8CHR_05048 ENOG4105D85 methylase RA8CHR_05052 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) RA8CHR_05053 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) RA8CHR_05054 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) RA8CHR_05055 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) RA8CHR_05056 ENOG4105CEN a g-specific adenine glycosylase RA8CHR_05057 ENOG410890F Dynamin family RA8CHR_05058 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) RA8CHR_05061 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) RA8CHR_05063 ENOG4105C5T Phosphoribosyl pyrophosphate synthase RA8CHR_05064 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) RA8CHR_05065 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) RA8CHR_05067 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding RA8CHR_05069 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA8CHR_05071 ENOG4108JQ7 (ABC) transporter RA8CHR_05072 ENOG4105DEF Extracellular solute-binding protein, family 5 RA8CHR_05073 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8CHR_05080 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) RA8CHR_05081 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) RA8CHR_05082 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) RA8CHR_05083 ENOG4107QSN dihydrolipoamide acetyltransferase RA8CHR_05084 ENOG4107QN2 dihydrolipoyl dehydrogenase RA8CHR_05085 ENOG4105EV9 Alpha Beta Hydrolase RA8CHR_05086 ENOG4105C6K Malic enzyme RA8CHR_05088 ENOG4105CEP NADH dehydrogenase RA8CHR_05089 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_05090 ENOG4105CHR reductase RA8CHR_05091 ENOG4105CQZ Histidine kinase RA8CHR_05092 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family RA8CHR_05093 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) RA8CHR_05094 ENOG4105E7W lamb ycsf family protein RA8CHR_05095 ENOG4107R7A Allophanate hydrolase subunit 2 RA8CHR_05096 ENOG4105P4J Allophanate hydrolase, subunit 1 RA8CHR_05097 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) RA8CHR_05098 ENOG4106H78 methyltransferase RA8CHR_05103 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA8CHR_05105 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) RA8CHR_05110 ENOG4107QS1 Cytochrome C Oxidase, Subunit III RA8CHR_05112 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) RA8CHR_05114 ENOG4105BZ9 Cytochrome C oxidase, subunit I RA8CHR_05117 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) RA8CHR_05119 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) RA8CHR_05121 ENOG4105D1F ATP-binding protein RA8CHR_05125 ENOG4105E9F Enoyl-CoA hydratase RA8CHR_05130 ENOG4105CSU acyl-Coa dehydrogenase RA8CHR_05135 ENOG4105E0Y RtcB Protein RA8CHR_05136 ENOG4105CIF Ornithine Cyclodeaminase RA8CHR_05137 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_05138 ENOG4107QNJ CoA-transferase subunit B RA8CHR_05140 ENOG4107HP6 Transcriptional regulator RA8CHR_05144 ENOG4105MWK D-amino acid dehydrogenase, small subunit RA8CHR_05145 ENOG4105K70 DNA-binding protein RA8CHR_05151 ENOG4108K2P TRANSCRIPTIONal RA8CHR_05153 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_05155 ENOG4105E2B Taurine dioxygenase RA8CHR_05164 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) RA8CHR_05166 ENOG4105MWK D-amino acid dehydrogenase, small subunit RA8CHR_05167 ENOG4105C26 Dehydrogenase RA8CHR_05168 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) RA8CHR_05169 ENOG4105EVZ LysR family transcriptional regulator RA8CHR_05170 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) RA8CHR_05174 ENOG4105VG5 Membrane RA8CHR_05178 ENOG4105VFU Rna-binding protein RA8CHR_05180 ENOG4105D44 asparaginase RA8CHR_05181 ENOG4108JQ6 ABC transporter RA8CHR_05182 ENOG4105DEF Extracellular solute-binding protein, family 5 RA8CHR_05184 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA8CHR_05198 ENOG4108IV0 ABC, transporter RA8CHR_05199 ENOG4108IUZ ABC transporter RA8CHR_05203 ENOG4105C26 Dehydrogenase RA8CHR_05205 ENOG4105G9V cytochrome C RA8CHR_05206 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein RA8CHR_05211 ENOG4105DDW LysR family Transcriptional regulator RA8CHR_05214 ENOG4106RE7 Cytochrome RA8CHR_05215 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) RA8CHR_05241 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) RA8CHR_05244 ENOG4108Z20 Acyl-transferase RA8CHR_05245 ENOG4105CD3 dihydroorotase RA8CHR_05246 ENOG4105CXT aspartate transcarbamylase RA8CHR_05247 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) RA8CHR_05248 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) RA8CHR_05249 ENOG4108UJU UPF0301 protein RA8CHR_05250 ENOG4105CVP deoxyribo-dipyrimidine photolyase RA8CHR_05252 ENOG4105C8Q Methyl-accepting chemotaxis RA8CHR_05254 ENOG4105M3Z response regulator RA8CHR_05255 ENOG4108UNF response regulator RA8CHR_05257 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase RA8CHR_05258 ENOG4105DC1 bifunctional purine biosynthesis protein purh RA8CHR_05260 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) RA8CHR_05261 ENOG4105W39 Membrane RA8CHR_05262 ENOG4105C3G gtp-binding protein RA8CHR_05263 ENOG4105QVC MOSC domain-containing protein RA8CHR_05264 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family RA8CHR_05267 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_05275 ENOG4108QBV Monogalactosyldiacylglycerol synthase RA8CHR_05278 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) RA8CHR_05279 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase RA8CHR_05280 ENOG4105E8V Alpha Beta Hydrolase Fold protein RA8CHR_05281 ENOG41077RS Phosphatase RA8CHR_05284 ENOG4108HPI phosphatidate Cytidylyltransferase RA8CHR_05285 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) RA8CHR_05286 ENOG4105C9A Phoh family RA8CHR_05287 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) RA8CHR_05288 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) RA8CHR_05293 ENOG4105DR5 peptidase RA8CHR_05294 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) RA8CHR_05295 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA8CHR_05296 ENOG4108YX9 iron--sulfur cluster insertion protein erpA RA8CHR_05297 ENOG4108UJD 30S ribosomal protein S9 RA8CHR_05298 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) RA8CHR_05299 ENOG4105D6S protein involved in catabolism of external DNA RA8CHR_05301 ENOG4105SYT Methylenetetrahydrofolate reductase RA8CHR_05303 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) RA8CHR_05304 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) RA8CHR_05309 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8CHR_05311 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) RA8CHR_05313 ENOG4105CSH Transporter RA8CHR_05317 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase RA8CHR_05318 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase RA8CHR_05320 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) RA8CHR_05321 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) RA8CHR_05323 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) RA8CHR_05326 ENOG4108IPT Naphthoate synthase RA8CHR_05328 ENOG4107QX3 carboxylase RA8CHR_05329 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_05330 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_05333 ENOG4107URF beta-phospho-glucomutase RA8CHR_05334 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) RA8CHR_05338 ENOG4105K5B UPF0225 protein RA8CHR_05343 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_05345 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_05346 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) RA8CHR_05347 ENOG41077A9 carbonic anhydrase RA8CHR_05348 ENOG4108Z6Z Transcriptional regulator RA8CHR_05351 ENOG4105D3G Pseudouridine synthase RA8CHR_05352 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_05354 ENOG4105CHR reductase RA8CHR_05357 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase RA8CHR_05358 ENOG4105C38 Glycyl-tRNA synthetase beta subunit RA8CHR_05359 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit RA8CHR_05363 ENOG4105CAU Arsenical resistance protein, ArsH RA8CHR_05364 ENOG4105D6J arsenicaL-resistance protein RA8CHR_05372 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component RA8CHR_05374 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) RA8CHR_05375 ENOG4108JU5 Magnesium and cobalt efflux protein RA8CHR_05377 ENOG4105J0Q Transcriptional regulator RA8CHR_05379 ENOG4105F87 Dehydratase RA8CHR_05380 ENOG4105MIR Phenylalanine 4-monooxygenase RA8CHR_05382 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_05389 ENOG4105C5H ABC transporter RA8CHR_05390 ENOG4107RZC phospholipase d RA8CHR_05391 ENOG4105CHM Aminotransferase RA8CHR_05393 ENOG4105T38 integral membrane protein RA8CHR_05394 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA8CHR_05395 ENOG4108NIW Leucine export protein LeuE RA8CHR_05396 ENOG4108TGY Glutathione S-transferase RA8CHR_05397 ENOG4105JAB phenazine biosynthesis protein, phzf family RA8CHR_05402 ENOG4105F4K antigen 43 RA8CHR_05404 ENOG4105VF7 tolerance protein RA8CHR_05407 ENOG4108V1U phospholipid-binding protein RA8CHR_05412 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) RA8CHR_05413 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen RA8CHR_05414 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) RA8CHR_05415 ENOG4105C25 Primosomal protein n' RA8CHR_05418 ENOG4105RK9 auxin efflux carrier RA8CHR_05419 ENOG4105C4R Atp-dependent dna helicase RA8CHR_05421 ENOG4105HDD phospholipase RA8CHR_05423 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein RA8CHR_05433 ENOG4105CHR reductase RA8CHR_05434 ENOG41073TP transcriptional regulator RA8CHR_05435 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_05440 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_05444 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_05449 ENOG4105CC9 acyl-Coa dehydrogenase RA8CHR_05450 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_05451 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_05454 ENOG4105EA8 2-Nitropropane dioxygenase RA8CHR_05457 ENOG4105CPC Aldo Keto reductase RA8CHR_05460 ENOG4105E39 Enoyl-CoA hydratase RA8CHR_05463 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_05465 ENOG4108IV0 ABC, transporter RA8CHR_05466 ENOG4105C0Z ABC transporter RA8CHR_05467 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_05469 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein RA8CHR_05473 ENOG4105CGU Enoyl-CoA hydratase RA8CHR_05474 ENOG4105CHR reductase RA8CHR_05477 ENOG4105CGU Enoyl-CoA hydratase RA8CHR_05493 ENOG4105ES5 Histidine kinase RA8CHR_05495 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B RA8CHR_05497 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) RA8CHR_05498 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) RA8CHR_05499 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) RA8CHR_05500 ENOG4108VZM 50s ribosomal protein L10 RA8CHR_05501 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) RA8CHR_05502 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) RA8CHR_05504 ENOG4105PM1 preprotein translocase subunit SecE RA8CHR_05506 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) RA8CHR_05510 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) RA8CHR_05511 ENOG4105DK0 Indole-3-glycerol phosphate synthase RA8CHR_05512 ENOG4107QYG anthranilate phosphoribosyltransferase RA8CHR_05513 ENOG410829K Lysine exporter protein (Lyse ygga) RA8CHR_05515 ENOG4105DDQ anthranilate synthase RA8CHR_05520 ENOG4105CHR reductase RA8CHR_05522 ENOG4108IV0 ABC, transporter RA8CHR_05524 ENOG4105C0Z ABC transporter RA8CHR_05525 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_05528 ENOG4105FUY alpha subunit RA8CHR_05531 ENOG4105CHR reductase RA8CHR_05532 ENOG4106IPI cyclase, family RA8CHR_05534 ENOG4105CHU acetyl-coa acetyltransferase RA8CHR_05535 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_05543 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family RA8CHR_05545 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase RA8CHR_05547 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) RA8CHR_05552 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_05566 ENOG4108ZF3 Phosphatase RA8CHR_05572 ENOG4105CS6 Rhs element vgr protein RA8CHR_05573 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) RA8CHR_05574 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit RA8CHR_05582 ENOG4105D9P serine threonine protein kinase RA8CHR_05585 ENOG4106VK6 Flagellar motor protein RA8CHR_05590 ENOG4105D5K Hemolysin activator protein RA8CHR_05591 ENOG4105EHI Phosphonate ABC transporter, periplasmic RA8CHR_05592 ENOG4105EHI Phosphonate ABC transporter, periplasmic RA8CHR_05600 ENOG4105C75 arginyL-tRNA synthetase RA8CHR_05603 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA RA8CHR_05604 ENOG4108IUZ ABC transporter RA8CHR_05605 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA8CHR_05606 ENOG4107RZC phospholipase d RA8CHR_05615 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_05616 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) RA8CHR_05619 ENOG4105C2X Arabinose 5-phosphate isomerase RA8CHR_05620 ENOG4105NVB glycoside hydrolase, family 19 RA8CHR_05623 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving RA8CHR_05628 ENOG4108ZAI phosphatidylglycerophosphatase a RA8CHR_05637 ENOG4105DND Transcriptional regulator RA8CHR_05639 ENOG4105WH1 Two component transcriptional regulator luxr family RA8CHR_05640 ENOG4105BZU Histidine kinase RA8CHR_05644 ENOG4108IMY Transcriptional regulator RA8CHR_05645 ENOG4107W7X Aldolase RA8CHR_05646 ENOG4105CH5 extracellular solute-binding protein, family 7 RA8CHR_05648 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) RA8CHR_05649 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) RA8CHR_05651 ENOG4105NWN ApaG protein RA8CHR_05652 ENOG4105DJV ribulose-phosphate 3-epimerase RA8CHR_05658 ENOG4108Z9W Outer membrane porin RA8CHR_05659 ENOG4105EB3 Histidine kinase RA8CHR_05660 ENOG4105E3W Two component transcriptional regulator (Winged helix family RA8CHR_05663 ENOG4105DQE DNA ligase RA8CHR_05667 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8CHR_05669 ENOG4105EQX glucarate dehydratase RA8CHR_05671 ENOG4105ETE Transcriptional regulator (LacI family RA8CHR_05672 ENOG4105D9P serine threonine protein kinase RA8CHR_05677 ENOG4105D5K Hemolysin activator protein RA8CHR_05682 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_05683 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase RA8CHR_05684 ENOG4107258 Transcriptional regulator RA8CHR_05685 ENOG4105CIH Imidazole acetol-phosphate transaminase RA8CHR_05686 ENOG4107QP3 malate synthase g RA8CHR_05691 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_05693 ENOG4105F2C Acetyl-CoA acetyltransferase RA8CHR_05694 ENOG4108UKI Enoyl-CoA hydratase RA8CHR_05695 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_05699 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 RA8CHR_05701 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA8CHR_05702 ENOG4105E7A Glutamine amidotransferase RA8CHR_05704 ENOG4105D7Z glutathione synthase RA8CHR_05705 ENOG4105DKK Benzoate RA8CHR_05706 ENOG4105DFH Transport of potassium into the cell (By similarity) RA8CHR_05708 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) RA8CHR_05709 ENOG4105DJF DNA polymerase III, delta' subunit RA8CHR_05711 ENOG4105C8T Leucyl-tRNA synthetase RA8CHR_05712 ENOG4105SG9 biopolymer transport protein, ExbD RA8CHR_05714 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) RA8CHR_05715 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) RA8CHR_05716 ENOG41090R7 Ferric uptake RA8CHR_05717 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) RA8CHR_05718 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN RA8CHR_05719 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA RA8CHR_05720 ENOG4105C4R Atp-dependent dna helicase RA8CHR_05721 ENOG4107QUT magnesium and cobalt transport protein CorA RA8CHR_05723 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_05724 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) RA8CHR_05725 ENOG4105W8H transhydrogenase (subunit alpha RA8CHR_05726 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) RA8CHR_05727 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA8CHR_05730 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) RA8CHR_05732 ENOG4105DEN Luciferase family RA8CHR_05736 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA8CHR_05737 ENOG4107WZ3 Transferase RA8CHR_05738 ENOG4105D3Q Sugar transferase RA8CHR_05740 ENOG4105E2K Glycosyl transferase (Group 1 RA8CHR_05744 ENOG4108UUM single-stranded DNA-binding protein RA8CHR_05745 ENOG4105CMQ Chloride channel RA8CHR_05747 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) RA8CHR_05748 ENOG4108594 Permease of the drug metabolite transporter RA8CHR_05749 ENOG4105C29 acyl-CoA thioesterase RA8CHR_05753 ENOG4105MSY salicylate hydroxylase RA8CHR_05756 ENOG4108KB2 LysR family Transcriptional regulator RA8CHR_05758 ENOG4105BZU Histidine kinase RA8CHR_05758 ENOG4105BZU Histidine kinase RA8CHR_05760 ENOG4105ETX regulatoR RA8CHR_05761 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_05762 ENOG4105F1J Homogentisate 1,2-dioxygenase RA8CHR_05764 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase RA8CHR_05774 ENOG4105SKN orotidine 5''-phosphate decarboxylase RA8CHR_05776 ENOG4105KEG ribosomal-protein-alanine acetyltransferase RA8CHR_05777 ENOG41072GX Peptidase M22 Glycoprotease RA8CHR_05780 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) RA8CHR_05781 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit RA8CHR_05782 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) RA8CHR_05783 ENOG4107QR8 Thioredoxin RA8CHR_05785 ENOG4107RYR Transcriptional regulator, Crp Fnr family RA8CHR_05787 ENOG4105C8V SAICAR synthetase RA8CHR_05789 ENOG4105CA9 Pyruvate kinase RA8CHR_05790 ENOG4105BZA Phosphoglycerate kinase RA8CHR_05791 ENOG4105F04 LysR family Transcriptional regulator RA8CHR_05794 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase RA8CHR_05798 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) RA8CHR_05800 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) RA8CHR_05802 ENOG4105C79 DNA protecting protein DprA RA8CHR_05803 ENOG4108RPN Protein smg homolog RA8CHR_05805 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) RA8CHR_05806 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) RA8CHR_05807 ENOG4105VIE preprotein translocase, subunit YajC RA8CHR_05810 ENOG4108YXU transcriptional regulator AsnC family RA8CHR_05811 ENOG4107SFI Major Facilitator superfamily RA8CHR_05812 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family RA8CHR_05813 ENOG4105P52 geranylgeranyl reductase RA8CHR_05819 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) RA8CHR_05820 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) RA8CHR_05821 ENOG4105FB2 class II Aldolase RA8CHR_05822 ENOG4105G63 Type III effector Hrp-dependent RA8CHR_05823 ENOG4105ZXK Dehydrogenase RA8CHR_05828 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) RA8CHR_05830 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha RA8CHR_05831 ENOG4105CMV Succinyl-CoA synthetase subunit beta RA8CHR_05833 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_05834 ENOG4105BZU Histidine kinase RA8CHR_05836 ENOG4105CFN oxalyl-CoA decarboxylase RA8CHR_05845 ENOG4105C1J atp-dependent rna helicase RA8CHR_05846 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) RA8CHR_05847 ENOG4105C0H protease RA8CHR_05849 ENOG4108Z86 Glutamine amidotransferase RA8CHR_05851 ENOG4105C9U ATP-dependent DNA helicase RecQ RA8CHR_05853 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase RA8CHR_05855 ENOG4105DHQ Histidine kinase RA8CHR_05858 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) RA8CHR_05859 ENOG4108004 Modulates RecA activity (By similarity) RA8CHR_05860 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase RA8CHR_05861 ENOG4105CMV Succinyl-CoA synthetase subunit beta RA8CHR_05862 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha RA8CHR_05863 ENOG4108ZCF integral membrane protein RA8CHR_05864 ENOG4108ZF3 Phosphatase RA8CHR_05866 ENOG4105F8J Adenylate Guanylate cyclase RA8CHR_05868 ENOG4105KHS type IV fimbrial pilin protein RA8CHR_05870 ENOG4108YSG O-Antigen polymerase RA8CHR_05877 ENOG4105E2K Glycosyl transferase (Group 1 RA8CHR_05880 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA8CHR_05889 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) RA8CHR_05890 ENOG4105ERG peptidase m48, ste24p RA8CHR_05891 ENOG41086DT Membrane protein of unknown function RA8CHR_05893 ENOG4108ZCF integral membrane protein RA8CHR_05897 ENOG4108VWS Yaeq family RA8CHR_05898 ENOG4107QTF adenylosuccinate lyase RA8CHR_05900 ENOG4108M3P Membrane RA8CHR_05901 ENOG4108U78 Glutathione S-transferase RA8CHR_05904 ENOG4108KPJ rna polymerase sigma factor RA8CHR_05905 ENOG4105K6T rare lipoprotein A RA8CHR_05906 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) RA8CHR_05909 ENOG4105BZU Histidine kinase RA8CHR_05910 ENOG4108ZXC Two component transcriptional regulator, luxr family RA8CHR_05917 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) RA8CHR_05921 ENOG4108YXU transcriptional regulator AsnC family RA8CHR_05922 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) RA8CHR_05923 ENOG4108RZE Tetr family transcriptional regulator RA8CHR_05933 ENOG4105CEV competence damage-inducible protein RA8CHR_05935 ENOG4105CYX Short-chain dehydrogenase reductase Sdr RA8CHR_05936 ENOG4107S2Z UPF0761 membrane protein RA8CHR_05937 ENOG4107R11 Transcriptional regulator RA8CHR_05938 ENOG4107GJV short-chain dehydrogenase reductase RA8CHR_05939 ENOG4107JEE Short-chain dehydrogenase reductase Sdr RA8CHR_05940 ENOG4108YZY peptidylprolyl cis-trans isomerase RA8CHR_05943 ENOG4105EUB pirin domain protein RA8CHR_05948 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_05949 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8CHR_05951 ENOG4105ETT transcriptional Regulator, LysR family RA8CHR_05952 ENOG4105F04 LysR family Transcriptional regulator RA8CHR_05954 ENOG4105MSY salicylate hydroxylase RA8CHR_05957 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase RA8CHR_05959 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_05960 ENOG4105BZU Histidine kinase RA8CHR_05961 ENOG4105BZU Histidine kinase RA8CHR_05962 ENOG4107Z5C methylesterase RA8CHR_05964 ENOG4105CPC Aldo Keto reductase RA8CHR_05967 ENOG4105EHI Phosphonate ABC transporter, periplasmic RA8CHR_05968 ENOG4105D5T phosphonate abc transporter RA8CHR_05971 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) RA8CHR_05975 ENOG4105CJ2 (LipO)protein RA8CHR_05978 ENOG4105FD8 phosphonate metabolism protein PhnM RA8CHR_05979 ENOG4105HRV phosphonate c-p lyase system protein phnl RA8CHR_05980 ENOG4105ENV phosphonate C-P lyase system protein PhnK RA8CHR_05981 ENOG4105FT8 Phosphonate metabolism RA8CHR_05984 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG RA8CHR_05986 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) RA8CHR_05988 ENOG4105CBN LysR family transcriptional regulator RA8CHR_05991 ENOG4105BZU Histidine kinase RA8CHR_05993 ENOG4108UXN response regulator RA8CHR_06000 ENOG4107S2Z UPF0761 membrane protein RA8CHR_06003 ENOG4105JAB phenazine biosynthesis protein, phzf family RA8CHR_06006 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) RA8CHR_06012 ENOG4108Z9W Outer membrane porin RA8CHR_06014 ENOG4105CKI cobalamin synthesis protein RA8CHR_06018 ENOG4105ERH Fumarylacetoacetate hydrolase RA8CHR_06019 ENOG41063Z6 transcriptional regulator, lysR family RA8CHR_06022 ENOG4105CSH Transporter RA8CHR_06023 ENOG4106NZI LysR family Transcriptional regulator RA8CHR_06025 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein RA8CHR_06028 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) RA8CHR_06029 ENOG4108IV0 ABC, transporter RA8CHR_06030 ENOG4105C0Z ABC transporter RA8CHR_06031 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_06032 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_06033 ENOG41083Z3 extracellular ligand-binding receptor RA8CHR_06034 ENOG4108WUH Transcriptional regulator, TetR family RA8CHR_06038 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family RA8CHR_06040 ENOG4105CR8 Transcriptional regulator RA8CHR_06045 ENOG4105ECQ AraC Family Transcriptional Regulator RA8CHR_06051 ENOG4105DND Transcriptional regulator RA8CHR_06054 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_06057 ENOG4105C32 Amino acid ABC transporter (Permease) RA8CHR_06058 ENOG4105C0Z ABC transporter RA8CHR_06059 ENOG4108IV0 ABC, transporter RA8CHR_06060 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) RA8CHR_06062 ENOG4105WEF catalase RA8CHR_06070 ENOG4105C9U ATP-dependent DNA helicase RecQ RA8CHR_06074 ENOG4105EHU Circadian clock protein KaiC RA8CHR_06075 ENOG4105BZU Histidine kinase RA8CHR_06077 ENOG4105HSS phospholipase C RA8CHR_06078 ENOG4105P69 integral membrane protein RA8CHR_06079 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_06080 ENOG4105EGI Transcriptional regulator RA8CHR_06083 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8CHR_06085 ENOG4107258 Transcriptional regulator RA8CHR_06087 ENOG4105EMY transcriptional regulator RA8CHR_06088 ENOG4105CHR reductase RA8CHR_06096 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase RA8CHR_06108 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) RA8CHR_06110 ENOG4105DIA mandelate racemase muconate lactonizing RA8CHR_06112 ENOG4108YAB Invasion protein RA8CHR_06123 ENOG4105C1G acyl-Coa dehydrogenase RA8CHR_06124 ENOG4105CEY Amp-dependent synthetase and ligase RA8CHR_06125 ENOG4105F04 LysR family Transcriptional regulator RA8CHR_06132 ENOG4105CQB FAD linked oxidase domain protein RA8CHR_06134 ENOG4105C5R Aminotransferase RA8CHR_06138 ENOG4108VX5 3-methyladenine DNA glycosylase RA8CHR_06145 ENOG4105DZR Type I site-specific deoxyribonuclease RA8CHR_06149 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase RA8CHR_06150 ENOG4105CV1 Transketolase (EC 2.2.1.1) RA8CHR_06151 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) RA8CHR_06152 ENOG4108S0S Nucleotidyl transferase RA8CHR_06156 ENOG4107RAQ aminopeptidase RA8CHR_06164 ENOG4105C6K Malic enzyme RA8CHR_06168 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) RA8CHR_06169 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) RA8CHR_06170 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) RA8CHR_06171 ENOG4105EHM Aminoglycoside phosphotransferase RA8CHR_06172 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) RA8CHR_06175 ENOG4105DXI Major Facilitator superfamily RA8CHR_06176 ENOG4105E5G Alpha beta hydrolase fold RA8CHR_06180 ENOG4105EYW Ion transport protein RA8CHR_06181 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein RA8CHR_06182 ENOG4105DWV Homoserine O-trans-acetylase RA8CHR_06183 ENOG4105DWV Homoserine O-trans-acetylase RA8CHR_06185 ENOG4105VFU Rna-binding protein RA8CHR_06186 ENOG4107FW0 short-chain dehydrogenase reductase RA8CHR_06188 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase RA8CHR_06189 ENOG4105C2X Arabinose 5-phosphate isomerase RA8CHR_06193 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) RA8CHR_06194 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins RA8CHR_06195 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) RA8CHR_06196 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) RA8P1_00013 ENOG4105CMM transposase RA8P1_00019 ENOG4105DTN riboflavin biosynthesis protein ribF RA8P1_00027 ENOG4105D2S major facilitator superfamily RA8P1_00029 ENOG4107U91 Rhomboid family RA8P1_00030 ENOG4108KPJ rna polymerase sigma factor RA8P1_00031 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) RA8P1_00032 ENOG4105E5H Transposase RA8P1_00034 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation RA8P1_00036 ENOG4105F2I Transposase RA8P1_00039 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8P1_00041 ENOG4105EF7 Transcriptional regulator RA8P1_00045 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8P1_00052 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase RA8P1_00053 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase RA8P1_00054 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA8P1_00056 ENOG4107258 Transcriptional regulator RA8P1_00063 ENOG4107AUC RA8P1_00064 ENOG4105JZI cytochrome P450 RA8P1_00070 ENOG4107AUC RA8P1_00073 ENOG4105NTD Inherit from COG: Hydrolase RA8P1_00076 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) RA8P1_00086 ENOG4108FUF Transcriptional regulator, IclR family RA8P1_00088 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) RA8P1_00091 ENOG4105CG6 trap dicarboxylate transporter dctm subunit RA8P1_00103 ENOG4105E39 Enoyl-CoA hydratase RA8P1_00106 ENOG4105DZS Phenylacetate-CoA ligase RA8P1_00111 ENOG4105C0Z ABC transporter RA8P1_00112 ENOG4108IV0 ABC, transporter RA8P1_00113 ENOG4105CQB FAD linked oxidase domain protein RA8P1_00114 ENOG4108YXU transcriptional regulator AsnC family RA8P1_00120 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA8P1_00127 ENOG4105ETT transcriptional Regulator, LysR family RA8P1_00128 ENOG4105ETE Transcriptional regulator (LacI family RA8P1_00131 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F RA8P1_00132 ENOG4105E39 Enoyl-CoA hydratase RA8P1_00133 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase RA8P1_00168 ENOG4108BUD transposase RA8P1_00175 ENOG4105MP0 transposase RA8P1_00182 ENOG4105C4R Atp-dependent dna helicase RA8P1_00188 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA8P1_00203 ENOG4105C0B DNA polymerase III (alpha subunit) RA8P1_00212 ENOG4105DQE DNA ligase RA8P1_00213 ENOG4105DQE DNA ligase RA8P1_00217 ENOG4105EP1 Efflux transporter rnd family, mfp subunit RA8P1_00218 ENOG4108IJF Heavy metal efflux pump, CzcA RA8P1_00222 ENOG4105E98 transcriptional regulator DeoR family RA8P1_00223 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) RA8P1_00226 ENOG4105W1Y Transcriptional regulator RA8P1_00227 ENOG4107SJW iron permease, FTR1 RA8P1_00231 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) RA8P1_00232 ENOG4105CVI Transcriptional regulator RA8P1_00236 ENOG4107QKA exodeoxyribonuclease V beta RA8P1_00237 ENOG4105CPB ATP-dependent endonuclease of the OLD family RA8P1_00249 ENOG4105E5H Transposase RA8P1_00251 ENOG4105MZG transcriptional modulator of maze toxin, mazf RA8P1_00252 ENOG4106A2Z transcriptional regulator antitoxin, MazE RA8P1_00253 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) RA8P1_00254 ENOG4105JN3 extra-cytoplasmic solute receptor family protein RA8P1_00255 ENOG4106NZI LysR family Transcriptional regulator RA8P1_00259 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) RA8P1_00262 ENOG4105CHR reductase RA8P1_00264 ENOG4105E5Q amino acid AbC transporter RA8P1_00265 ENOG4105E5Q amino acid AbC transporter RA8P1_00270 ENOG4105MP9 class II Aldolase RA8P1_00271 ENOG41079YP Citrate utilization protein b RA8P1_00272 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) RA8P1_00274 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8P1_00278 ENOG4108M0I Transcriptional regulator RA8P1_00282 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA8P1_00288 ENOG4107RGD Major Facilitator superfamily RA8P1_00290 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) RA8P1_00292 ENOG4105EKE dihydroorotase RA8P1_00294 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) RA8P1_00298 ENOG4107QY8 reductase RA8P1_00299 ENOG4108JIG Anaerobic dehydrogenase RA8P1_00307 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase RA8P1_00308 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) RA8P1_00309 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) RA8P1_00311 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA8P1_00312 ENOG4105CKK Glycosyl transferase, family 2 RA8P1_00313 ENOG4105C3I Nad-dependent epimerase dehydratase RA8P1_00315 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) RA8P1_00317 ENOG4105DIJ Phosphoethanolamine transferase RA8P1_00331 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) RA8P1_00334 ENOG4105CWC Acetylornithine deacetylase RA8P1_00337 ENOG4105FA0 parb-like partition protein RA8P1_00347 ENOG4105CMM transposase RA8P1_00351 ENOG4108PCE TRANSFER protein RA8P1_00352 ENOG4105CMA conjugation trbi family protein RA8P1_00354 ENOG4108EHY type IV secretion system RA8P1_00364 ENOG4105CN1 protease RA8P1_00366 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) RA8P1_00369 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) RA8P1_00381 ENOG4105D7T ABC transporter RA8P1_00382 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component RA8P1_00383 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component RA8P1_00384 ENOG4107XCH Cyclase family RA8P1_00387 ENOG4105CF7 AraC family transcriptional regulator RA8P1_00388 ENOG4105CF7 AraC family transcriptional regulator RA8P1_00389 ENOG4106PGW Short-chain dehydrogenase reductase Sdr RA8P1_00394 ENOG4105FDP GntR family transcriptional regulator RA8P1_00397 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) RA8P1_00398 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8P1_00399 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA8P1_00402 ENOG4105CHR reductase RA8P1_00403 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) RA8P1_00405 ENOG4105CMM transposase RA8P1_00418 ENOG4108XM1 transcriptional regulator AsnC family RA8P1_00422 ENOG4105CDA abc transporter atp-binding protein RA8P2_00010 ENOG4105CZX twitching motility protein RA8P2_00013 ENOG4105BZU Histidine kinase RA8P2_00032 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) RA8P2_00047 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) RA8P2_00106 ENOG4108T9W RNA methylase RA8P2_00110 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA8P2_00111 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA8P2_00143 ENOG4105EP1 Efflux transporter rnd family, mfp subunit RA8P2_00144 ENOG4108IJF Heavy metal efflux pump, CzcA RA8P2_00158 ENOG4105C59 p-type ATPase RA8P2_00159 ENOG4108Z6Z Transcriptional regulator RA8P2_00164 ENOG4106RE7 Cytochrome RA8P2_00165 ENOG4105RQF LysR family Transcriptional regulator RA8P2_00167 ENOG4105C28 cystathionine RA8P2_00168 ENOG4107RP9 extracellular solute-binding protein, family 3 RA8P2_00169 ENOG4105EAD ABC transporter RA8P2_00170 ENOG4105DRP amino acid AbC transporter RA8P2_00171 ENOG4105CDA abc transporter atp-binding protein RA8P2_00176 ENOG4105BZP glycoside hydrolase 15-related RA8P2_00182 ENOG4105C26 Dehydrogenase RA8P2_00188 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) RA8P2_00193 ENOG4107RZC phospholipase d RA8P2_00199 ENOG4105C5T Phosphoribosyl pyrophosphate synthase RA8P2_00200 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) RA8P2_00201 ENOG4105CY0 Metallo-Beta-Lactamase RA8P2_00206 ENOG4105CSR polyphosphate kinase 2 RA8P2_00220 ENOG4105E5H Transposase RA8P2_00224 ENOG4105CEY Amp-dependent synthetase and ligase RA8P2_00225 ENOG4105C0W non-ribosomal peptide synthetase RA8P2_00234 ENOG4108IPJ Membrane RA8P2_00256 ENOG4105CCU oxidase (Subunit III) RA8P2_00261 ENOG4105XIV Mercuric transport protein, periplasmic component RA8P2_00288 ENOG4105CKD glutathione-regulated potassium-efflux system protein RA8P2_00289 ENOG4105CKD glutathione-regulated potassium-efflux system protein RA8P2_00292 ENOG4105K78 MarR family Transcriptional regulator RA8P2_00293 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) RA8P2_00296 ENOG4105BZU Histidine kinase RA8P2_00297 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family RA8P2_00299 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) RA8P2_00300 ENOG4105QAX Iron-sulfur RA8P2_00308 ENOG4105EMN RNA polymerase sigma factor RA8P2_00310 ENOG4105XUA cytochrome c RA8P2_00311 ENOG4108RG0 uracil-dna glycosylase RA8P2_00312 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) RA8P2_00317 ENOG4108J5G 6-phosphogluconate dehydrogenase RA8P2_00328 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA8P2_00329 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA8P2_00335 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs RA8P2_00340 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) RA8P2_00365 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) RA8P2_00370 ENOG4105WH1 Two component transcriptional regulator luxr family RA8P2_00414 ENOG4105CDU Replicative dna helicase RA8P2_00419 ENOG41082IR Excinuclease ABC C subunit domain protein RA8P2_00431 ENOG4105DH7 May be involved in recombination (By similarity) RA8P2_00435 ENOG4105EQR Transposase IS116 IS110 IS902 RA8P2_00440 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) RA8P3_00016 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) RA8P3_00020 ENOG4105FDK ABC transporter