locus-tag	class	description
RA8CHR_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RA8CHR_00006	COG1408	metallophosphoesterase
RA8CHR_00009	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RA8CHR_00012	COG0392	lysyltransferase activity
RA8CHR_00013	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_00014	COG3568	Endonuclease Exonuclease Phosphatase
RA8CHR_00020	COG1178	ABC-type Fe3 transport system permease component
RA8CHR_00021	COG1176	ABC-type spermidine putrescine transport system, permease component I
RA8CHR_00023	COG3842	ATPase activity
RA8CHR_00024	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RA8CHR_00028	COG4452	Inner membrane protein CreD
RA8CHR_00030	COG2205	protein histidine kinase activity
RA8CHR_00031	COG0745	RESPONSE REGULATOR receiver
RA8CHR_00034	COG2608	mercury ion transmembrane transporter activity
RA8CHR_00036	COG0642	Histidine kinase
RA8CHR_00037	COG1902	pentaerythritol trinitrate reductase activity
RA8CHR_00038	COG0477	Major facilitator Superfamily
RA8CHR_00040	COG5487	UPF0391 membrane protein
RA8CHR_00042	COG0445	tRNA wobble uridine modification
RA8CHR_00043	COG0357	Ribosomal RNA small subunit methyltransferase G
RA8CHR_00045	COG1192	Involved in chromosome partitioning
RA8CHR_00047	COG1475	DNA binding
RA8CHR_00049	COG0277	FAD linked oxidase domain protein
RA8CHR_00050	COG2096	Adenosyltransferase
RA8CHR_00058	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RA8CHR_00060	COG0850	regulation of cytokinetic process
RA8CHR_00062	COG2233	PERMEase
RA8CHR_00063	COG2050	protein possibly involved in aromatic compounds catabolism
RA8CHR_00066	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RA8CHR_00074	COG3971	2-oxopent-4-enoate hydratase activity
RA8CHR_00075	COG0154	amidase activity
RA8CHR_00082	COG3210	domain, Protein
RA8CHR_00087	COG3246	L-lysine catabolic process to acetate
RA8CHR_00100	COG3246	L-lysine catabolic process to acetate
RA8CHR_00101	COG2175	clavaminate synthase activity
RA8CHR_00103	COG2233	PERMEase
RA8CHR_00108	COG0492	ferredoxin-NADP+ reductase activity
RA8CHR_00109	COG1715	Restriction endonuclease
RA8CHR_00117	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RA8CHR_00121	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RA8CHR_00132	COG2814	Major facilitator Superfamily
RA8CHR_00133	COG2205	protein histidine kinase activity
RA8CHR_00133	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA8CHR_00135	COG0484	heat shock protein binding
RA8CHR_00138	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00142	COG0745	RESPONSE REGULATOR receiver
RA8CHR_00145	COG0740	serine-type endopeptidase activity
RA8CHR_00150	COG1404	Belongs to the peptidase S8 family
RA8CHR_00155	COG3842	ATPase activity
RA8CHR_00156	COG1176	ABC-type spermidine putrescine transport system, permease component I
RA8CHR_00157	COG1177	transmembrane transport
RA8CHR_00160	COG0251	oxidation-reduction process
RA8CHR_00162	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RA8CHR_00165	COG1228	amidohydrolase
RA8CHR_00170	COG0181	hydroxymethylbilane synthase activity
RA8CHR_00175	COG1215	transferase activity, transferring glycosyl groups
RA8CHR_00176	COG1215	transferase activity, transferring glycosyl groups
RA8CHR_00177	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RA8CHR_00178	COG0457	Tetratricopeptide repeat
RA8CHR_00179	COG0791	NLP P60 protein
RA8CHR_00181	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_00184	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RA8CHR_00186	COG0583	DNA-binding transcription factor activity
RA8CHR_00187	COG0604	alcohol dehydrogenase
RA8CHR_00189	COG1024	Enoyl-CoA hydratase
RA8CHR_00191	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_00212	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RA8CHR_00214	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_00215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_00216	COG1752	Esterase of the alpha-beta hydrolase superfamily
RA8CHR_00221	COG2963	transposase activity
RA8CHR_00222	COG2801	Transposase and inactivated derivatives
RA8CHR_00224	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_00225	COG0006	proline dipeptidase activity
RA8CHR_00227	COG0583	DNA-binding transcription factor activity
RA8CHR_00229	COG0612	Peptidase, M16
RA8CHR_00231	COG1902	pentaerythritol trinitrate reductase activity
RA8CHR_00232	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RA8CHR_00232	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RA8CHR_00234	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RA8CHR_00239	COG3459	Glycosyltransferase 36 associated
RA8CHR_00246	COG4221	oxidoreductase activity
RA8CHR_00247	COG0697	spore germination
RA8CHR_00248	COG0583	DNA-binding transcription factor activity
RA8CHR_00251	COG0583	DNA-binding transcription factor activity
RA8CHR_00253	COG1024	Enoyl-CoA hydratase
RA8CHR_00256	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_00260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RA8CHR_00263	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RA8CHR_00264	COG1950	PFAM Membrane protein of
RA8CHR_00269	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA8CHR_00270	COG0450	alkyl hydroperoxide reductase
RA8CHR_00272	COG0583	DNA-binding transcription factor activity
RA8CHR_00273	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_00274	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_00278	COG4221	oxidoreductase activity
RA8CHR_00282	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00282	COG0604	alcohol dehydrogenase
RA8CHR_00282	COG3321	synthase
RA8CHR_00283	COG3246	L-lysine catabolic process to acetate
RA8CHR_00285	COG3485	protocatechuate 3,4-dioxygenase
RA8CHR_00286	COG1609	Transcriptional regulator
RA8CHR_00287	COG0515	serine threonine protein kinase
RA8CHR_00291	COG0583	DNA-binding transcription factor activity
RA8CHR_00292	COG2066	Belongs to the glutaminase family
RA8CHR_00293	COG0697	spore germination
RA8CHR_00295	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_00298	COG2188	Transcriptional regulator
RA8CHR_00299	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RA8CHR_00300	COG0700	Nucleoside recognition
RA8CHR_00301	COG3540	Alkaline phosphatase
RA8CHR_00305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RA8CHR_00307	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RA8CHR_00308	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RA8CHR_00316	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_00319	COG2986	histidine ammonia-lyase
RA8CHR_00319	COG2986	histidine ammonia-lyase
RA8CHR_00320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RA8CHR_00325	COG1228	amidohydrolase
RA8CHR_00333	COG0583	DNA-binding transcription factor activity
RA8CHR_00335	COG1410	methionine synthase
RA8CHR_00335	COG0646	methionine synthase
RA8CHR_00339	COG0842	Transport permease protein
RA8CHR_00339	COG1131	(ABC) transporter
RA8CHR_00339	COG1716	ATPase activity
RA8CHR_00341	COG1309	transcriptional regulator
RA8CHR_00351	COG0411	ABC transporter
RA8CHR_00353	COG1335	isochorismatase
RA8CHR_00354	COG2080	2 iron, 2 sulfur cluster binding
RA8CHR_00355	COG2010	Cytochrome c
RA8CHR_00355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RA8CHR_00361	COG0606	chelatase, subunit chli
RA8CHR_00363	COG0347	Belongs to the P(II) protein family
RA8CHR_00364	COG0004	ammonium transporteR
RA8CHR_00366	COG0277	FAD linked oxidase domain protein
RA8CHR_00367	COG0247	lactate metabolic process
RA8CHR_00370	COG0386	Belongs to the glutathione peroxidase family
RA8CHR_00373	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RA8CHR_00375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RA8CHR_00377	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_00378	COG0129	dihydroxy-acid dehydratase activity
RA8CHR_00380	COG3971	2-oxopent-4-enoate hydratase activity
RA8CHR_00382	COG3384	dioxygenase
RA8CHR_00383	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_00387	COG1846	Transcriptional regulator
RA8CHR_00390	COG2974	May be involved in recombination
RA8CHR_00397	COG0745	RESPONSE REGULATOR receiver
RA8CHR_00398	COG0579	oxidoreductase
RA8CHR_00400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RA8CHR_00402	COG4691	Plasmid stability protein
RA8CHR_00403	COG2211	Major facilitator Superfamily
RA8CHR_00404	COG0501	Belongs to the peptidase M48B family
RA8CHR_00405	COG4221	oxidoreductase activity
RA8CHR_00406	COG0583	DNA-binding transcription factor activity
RA8CHR_00407	COG1335	isochorismatase
RA8CHR_00409	COG1574	metal-dependent hydrolase with the TIM-barrel fold
RA8CHR_00413	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA8CHR_00414	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_00422	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RA8CHR_00423	COG1335	isochorismatase
RA8CHR_00425	COG1335	isochorismatase
RA8CHR_00429	COG0583	DNA-binding transcription factor activity
RA8CHR_00430	COG0708	Exodeoxyribonuclease III
RA8CHR_00431	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RA8CHR_00433	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RA8CHR_00434	COG0154	amidase activity
RA8CHR_00435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RA8CHR_00436	COG1077	Cell shape determining protein MreB Mrl
RA8CHR_00439	COG0768	penicillin binding
RA8CHR_00441	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RA8CHR_00442	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RA8CHR_00446	COG2095	MarC family integral membrane protein
RA8CHR_00447	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00449	COG0412	Dienelactone hydrolase
RA8CHR_00451	COG0583	DNA-binding transcription factor activity
RA8CHR_00453	COG0598	Magnesium transport protein CorA
RA8CHR_00457	COG3411	Ferredoxin
RA8CHR_00458	COG2945	thiolester hydrolase activity
RA8CHR_00459	COG1686	Belongs to the peptidase S11 family
RA8CHR_00460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RA8CHR_00461	COG0049	tRNA binding
RA8CHR_00462	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RA8CHR_00463	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RA8CHR_00464	COG0051	transcription antitermination factor activity, RNA binding
RA8CHR_00467	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RA8CHR_00468	COG0088	Forms part of the polypeptide exit tunnel
RA8CHR_00469	COG0089	rRNA binding
RA8CHR_00470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RA8CHR_00471	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RA8CHR_00472	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RA8CHR_00473	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RA8CHR_00474	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RA8CHR_00475	COG0255	Belongs to the universal ribosomal protein uL29 family
RA8CHR_00476	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RA8CHR_00477	COG0678	peroxiredoxin activity
RA8CHR_00478	COG0456	acetyltransferase
RA8CHR_00480	COG3909	cytochrome
RA8CHR_00481	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA8CHR_00485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA8CHR_00486	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RA8CHR_00490	COG4251	negative regulation of phosphorylation
RA8CHR_00491	COG2130	NADP-dependent
RA8CHR_00494	COG2188	Transcriptional regulator
RA8CHR_00497	COG0114	fumarate hydratase activity
RA8CHR_00498	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RA8CHR_00499	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_00500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RA8CHR_00501	COG0321	lipoyl(octanoyl) transferase activity
RA8CHR_00502	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RA8CHR_00504	COG0356	it plays a direct role in the translocation of protons across the membrane
RA8CHR_00506	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RA8CHR_00507	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RA8CHR_00508	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RA8CHR_00509	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RA8CHR_00510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RA8CHR_00511	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RA8CHR_00513	COG1129	ABC transporter
RA8CHR_00514	COG1172	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_00515	COG1879	ABC-type sugar transport system periplasmic component
RA8CHR_00516	COG0673	inositol 2-dehydrogenase activity
RA8CHR_00525	COG1793	dna ligase
RA8CHR_00525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RA8CHR_00526	COG1793	dna ligase
RA8CHR_00527	COG1201	RNA secondary structure unwinding
RA8CHR_00539	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RA8CHR_00541	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA8CHR_00542	COG1309	transcriptional regulator
RA8CHR_00544	COG0582	viral genome integration into host DNA
RA8CHR_00553	COG1002	Type II restriction enzyme, methylase subunits
RA8CHR_00573	COG0210	DNA helicase
RA8CHR_00574	COG0514	ATP-dependent DNA helicase (RecQ)
RA8CHR_00581	COG2801	Transposase and inactivated derivatives
RA8CHR_00582	COG2801	Transposase and inactivated derivatives
RA8CHR_00585	COG0469	pyruvate kinase activity
RA8CHR_00587	COG2084	Dehydrogenase
RA8CHR_00588	COG0477	Major facilitator Superfamily
RA8CHR_00590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RA8CHR_00597	COG0477	Major facilitator Superfamily
RA8CHR_00604	COG3386	PFAM SMP-30 Gluconolaconase
RA8CHR_00605	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00607	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_00608	COG1879	ABC-type sugar transport system periplasmic component
RA8CHR_00609	COG4213	ABC transporter substrate-binding protein
RA8CHR_00611	COG4214	carbohydrate transport
RA8CHR_00612	COG1129	ABC transporter
RA8CHR_00613	COG1172	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_00614	COG1172	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_00619	COG0792	nuclease activity
RA8CHR_00620	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RA8CHR_00622	COG2084	Dehydrogenase
RA8CHR_00628	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RA8CHR_00634	COG3639	organic phosphonate transmembrane transporter activity
RA8CHR_00635	COG3639	organic phosphonate transmembrane transporter activity
RA8CHR_00636	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RA8CHR_00637	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RA8CHR_00638	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RA8CHR_00640	COG0709	Synthesizes selenophosphate from selenide and ATP
RA8CHR_00644	COG1309	transcriptional regulator
RA8CHR_00648	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RA8CHR_00648	COG2124	cytochrome p450
RA8CHR_00651	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_00652	COG0439	Biotin carboxylase
RA8CHR_00655	COG1346	cytolysis
RA8CHR_00656	COG1380	Effector of murein hydrolase LrgA
RA8CHR_00657	COG0277	FAD linked oxidase domain protein
RA8CHR_00666	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_00676	COG1473	amidohydrolase
RA8CHR_00679	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_00690	COG0343	queuine tRNA-ribosyltransferase activity
RA8CHR_00691	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RA8CHR_00692	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RA8CHR_00694	COG0783	Belongs to the Dps family
RA8CHR_00695	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RA8CHR_00697	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RA8CHR_00698	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RA8CHR_00699	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RA8CHR_00700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RA8CHR_00701	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RA8CHR_00702	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RA8CHR_00703	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RA8CHR_00704	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RA8CHR_00705	COG1841	ribosomal large subunit assembly
RA8CHR_00706	COG0200	Binds to the 23S rRNA
RA8CHR_00707	COG0201	protein transport
RA8CHR_00708	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RA8CHR_00709	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RA8CHR_00710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RA8CHR_00711	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RA8CHR_00712	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RA8CHR_00713	COG0202	RNA polymerase activity
RA8CHR_00714	COG0203	ribosomal protein L17
RA8CHR_00718	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_00719	COG1024	Enoyl-CoA hydratase
RA8CHR_00722	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RA8CHR_00727	COG0583	DNA-binding transcription factor activity
RA8CHR_00728	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00730	COG0022	dehydrogenase e1 component
RA8CHR_00731	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RA8CHR_00741	COG4213	ABC transporter substrate-binding protein
RA8CHR_00742	COG4214	carbohydrate transport
RA8CHR_00743	COG1129	ABC transporter
RA8CHR_00746	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_00747	COG0693	protein deglycase activity
RA8CHR_00754	COG1022	Amp-dependent synthetase and ligase
RA8CHR_00755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_00757	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00763	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RA8CHR_00764	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RA8CHR_00765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RA8CHR_00766	COG2205	protein histidine kinase activity
RA8CHR_00767	COG0745	RESPONSE REGULATOR receiver
RA8CHR_00769	COG1187	pseudouridine synthase activity
RA8CHR_00770	COG0745	RESPONSE REGULATOR receiver
RA8CHR_00784	COG0326	Molecular chaperone. Has ATPase activity
RA8CHR_00785	COG2124	cytochrome p450
RA8CHR_00786	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_00787	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_00788	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_00789	COG0583	DNA-binding transcription factor activity
RA8CHR_00790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RA8CHR_00792	COG1764	response to oxidative stress
RA8CHR_00793	COG1846	Transcriptional regulator
RA8CHR_00795	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA8CHR_00796	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RA8CHR_00801	COG0559	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_00815	COG2268	Band 7 protein
RA8CHR_00816	COG5564	TIM-barrel signal transduction protein
RA8CHR_00817	COG5441	Belongs to the UPF0261 family
RA8CHR_00822	COG1228	amidohydrolase
RA8CHR_00823	COG1228	amidohydrolase
RA8CHR_00824	COG0596	Alpha beta hydrolase
RA8CHR_00825	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_00828	COG2205	protein histidine kinase activity
RA8CHR_00830	COG0596	Alpha beta hydrolase
RA8CHR_00835	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_00837	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RA8CHR_00838	COG1652	LysM domain
RA8CHR_00840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RA8CHR_00848	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_00849	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RA8CHR_00851	COG0640	Transcriptional regulator
RA8CHR_00854	COG0625	glutathione transferase activity
RA8CHR_00855	COG0583	DNA-binding transcription factor activity
RA8CHR_00856	COG1131	(ABC) transporter
RA8CHR_00857	COG0842	Transport permease protein
RA8CHR_00858	COG2733	membrane
RA8CHR_00860	COG1473	amidohydrolase
RA8CHR_00863	COG0243	molybdopterin cofactor binding
RA8CHR_00881	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RA8CHR_00882	COG4106	trans-aconitate 2-methyltransferase activity
RA8CHR_00885	COG2076	Multidrug Resistance protein
RA8CHR_00887	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RA8CHR_00888	COG1086	Polysaccharide biosynthesis protein
RA8CHR_00896	COG0463	Glycosyl transferase, family 2
RA8CHR_00901	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RA8CHR_00903	COG0275	rRNA processing
RA8CHR_00905	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RA8CHR_00908	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA8CHR_00912	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RA8CHR_00912	COG0662	Cupin 2, conserved barrel domain protein
RA8CHR_00913	COG2755	lipolytic protein G-D-S-L family
RA8CHR_00913	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RA8CHR_00914	COG1216	Glycosyl transferase, family 2
RA8CHR_00914	COG0438	transferase activity, transferring glycosyl groups
RA8CHR_00915	COG1215	transferase activity, transferring glycosyl groups
RA8CHR_00918	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RA8CHR_00920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RA8CHR_00921	COG1309	transcriptional regulator
RA8CHR_00922	COG0753	catalase activity
RA8CHR_00926	COG1280	lysine exporter protein (LysE YggA)
RA8CHR_00927	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00929	COG0628	permease
RA8CHR_00932	COG0861	Integral membrane protein TerC family
RA8CHR_00940	COG2084	Dehydrogenase
RA8CHR_00941	COG0583	DNA-binding transcription factor activity
RA8CHR_00942	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RA8CHR_00944	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RA8CHR_00953	COG0671	phosphoesterase, PA-phosphatase related
RA8CHR_00955	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RA8CHR_00956	COG5002	protein histidine kinase activity
RA8CHR_00957	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RA8CHR_00958	COG2721	sulfolactate sulfo-lyase activity
RA8CHR_00959	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RA8CHR_00961	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_00962	COG2186	Transcriptional regulator
RA8CHR_00963	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00964	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_00965	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_00968	COG4191	Histidine kinase
RA8CHR_00969	COG4566	intracellular signal transduction
RA8CHR_00973	COG2076	Multidrug Resistance protein
RA8CHR_00974	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RA8CHR_00977	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_00979	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA8CHR_00979	COG1024	Enoyl-CoA hydratase
RA8CHR_00980	COG0183	Belongs to the thiolase family
RA8CHR_00983	COG1024	Enoyl-CoA hydratase
RA8CHR_00985	COG1607	acyl-coa hydrolase
RA8CHR_00986	COG5265	(ABC) transporter
RA8CHR_00987	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA8CHR_00989	COG0559	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_00990	COG1172	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_00991	COG0411	ABC transporter
RA8CHR_00994	COG3473	Maleate cis-trans isomerase
RA8CHR_00995	COG0596	Alpha beta hydrolase
RA8CHR_00996	COG2309	aminopeptidase activity
RA8CHR_00997	COG1335	isochorismatase
RA8CHR_00999	COG0583	DNA-binding transcription factor activity
RA8CHR_01001	COG0765	amino acid transport
RA8CHR_01002	COG0765	amino acid transport
RA8CHR_01003	COG1126	abc transporter atp-binding protein
RA8CHR_01004	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_01008	COG2271	Major facilitator Superfamily
RA8CHR_01015	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01016	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_01017	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_01018	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_01019	COG0183	Belongs to the thiolase family
RA8CHR_01021	COG0583	DNA-binding transcription factor activity
RA8CHR_01022	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RA8CHR_01025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RA8CHR_01026	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01030	COG0418	dihydroorotase activity
RA8CHR_01038	COG1414	Transcriptional regulator
RA8CHR_01039	COG0501	Belongs to the peptidase M48B family
RA8CHR_01040	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RA8CHR_01044	COG2226	methyltransferase
RA8CHR_01046	COG1187	pseudouridine synthase activity
RA8CHR_01047	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA8CHR_01048	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01053	COG0330	HflC and HflK could
RA8CHR_01054	COG0598	Magnesium transport protein CorA
RA8CHR_01057	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01061	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01063	COG2072	flavoprotein involved in K transport
RA8CHR_01065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RA8CHR_01068	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RA8CHR_01069	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RA8CHR_01070	COG0523	cobalamin synthesis protein
RA8CHR_01073	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RA8CHR_01074	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RA8CHR_01075	COG2001	Belongs to the MraZ family
RA8CHR_01076	COG0275	rRNA processing
RA8CHR_01079	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RA8CHR_01080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RA8CHR_01081	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RA8CHR_01082	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RA8CHR_01083	COG0772	Belongs to the SEDS family
RA8CHR_01084	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RA8CHR_01085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RA8CHR_01086	COG1181	Belongs to the D-alanine--D-alanine ligase family
RA8CHR_01087	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RA8CHR_01089	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RA8CHR_01090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RA8CHR_01092	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RA8CHR_01095	COG1595	DNA-templated transcription, initiation
RA8CHR_01099	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RA8CHR_01100	COG0575	Belongs to the CDS family
RA8CHR_01104	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RA8CHR_01107	COG3150	esterase
RA8CHR_01108	COG0772	Belongs to the SEDS family
RA8CHR_01109	COG0312	modulator of DNA gyrase
RA8CHR_01110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RA8CHR_01112	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RA8CHR_01114	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA8CHR_01115	COG0511	ligase activity, forming carbon-carbon bonds
RA8CHR_01116	COG0439	Biotin carboxylase
RA8CHR_01117	COG2264	protein methyltransferase activity
RA8CHR_01119	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA8CHR_01121	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RA8CHR_01128	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RA8CHR_01129	COG2943	transferase activity, transferring hexosyl groups
RA8CHR_01129	COG3416	Protein conserved in bacteria
RA8CHR_01130	COG2204	response regulator
RA8CHR_01132	COG2205	protein histidine kinase activity
RA8CHR_01133	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RA8CHR_01135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA8CHR_01136	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RA8CHR_01145	COG0037	tRNA processing
RA8CHR_01147	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_01155	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_01156	COG0583	DNA-binding transcription factor activity
RA8CHR_01157	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_01159	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RA8CHR_01160	COG3387	PFAM Glycoside hydrolase 15-related
RA8CHR_01162	COG0617	tRNA 3'-terminal CCA addition
RA8CHR_01164	COG1285	pathogenesis
RA8CHR_01165	COG0739	heme binding
RA8CHR_01165	COG0741	lytic transglycosylase activity
RA8CHR_01165	COG1196	nuclear chromosome segregation
RA8CHR_01166	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RA8CHR_01167	COG0583	DNA-binding transcription factor activity
RA8CHR_01170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_01174	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RA8CHR_01175	COG1522	sequence-specific DNA binding
RA8CHR_01188	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_01195	COG2828	Protein conserved in bacteria
RA8CHR_01196	COG1024	Enoyl-CoA hydratase
RA8CHR_01201	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA8CHR_01201	COG0045	succinate-CoA ligase (ADP-forming) activity
RA8CHR_01201	COG1042	CoA-binding domain protein
RA8CHR_01203	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RA8CHR_01204	COG0066	3-isopropylmalate dehydratase activity
RA8CHR_01224	COG0583	DNA-binding transcription factor activity
RA8CHR_01225	COG0436	Aminotransferase
RA8CHR_01227	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RA8CHR_01229	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RA8CHR_01233	COG0436	Aminotransferase
RA8CHR_01234	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_01235	COG3278	Belongs to the heme-copper respiratory oxidase family
RA8CHR_01237	COG2010	Cytochrome c
RA8CHR_01240	COG2826	transposase and inactivated derivatives, IS30 family
RA8CHR_01250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RA8CHR_01252	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_01255	COG1942	4-Oxalocrotonate Tautomerase
RA8CHR_01258	COG1414	Transcriptional regulator
RA8CHR_01269	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_01270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_01273	COG3118	belongs to the thioredoxin family
RA8CHR_01277	COG0492	ferredoxin-NADP+ reductase activity
RA8CHR_01278	COG0501	Belongs to the peptidase M48B family
RA8CHR_01279	COG4566	intracellular signal transduction
RA8CHR_01281	COG2823	Periplasmic or secreted lipoprotein
RA8CHR_01283	COG0071	Belongs to the small heat shock protein (HSP20) family
RA8CHR_01285	COG0542	response to heat
RA8CHR_01286	COG0745	RESPONSE REGULATOR receiver
RA8CHR_01286	COG2205	protein histidine kinase activity
RA8CHR_01286	COG4191	Histidine kinase
RA8CHR_01287	COG1802	Transcriptional regulator
RA8CHR_01290	COG2721	sulfolactate sulfo-lyase activity
RA8CHR_01291	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RA8CHR_01292	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RA8CHR_01294	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_01295	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01298	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_01301	COG0583	DNA-binding transcription factor activity
RA8CHR_01304	COG2814	Major facilitator Superfamily
RA8CHR_01305	COG0583	DNA-binding transcription factor activity
RA8CHR_01312	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RA8CHR_01320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_01322	COG2130	NADP-dependent
RA8CHR_01324	COG2814	Major facilitator Superfamily
RA8CHR_01331	COG3278	Belongs to the heme-copper respiratory oxidase family
RA8CHR_01338	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_01339	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RA8CHR_01342	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RA8CHR_01343	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RA8CHR_01345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_01346	COG0784	Response regulator, receiver
RA8CHR_01346	COG4191	Histidine kinase
RA8CHR_01349	COG3108	Peptidase M15
RA8CHR_01352	COG1136	(ABC) transporter
RA8CHR_01356	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_01360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RA8CHR_01362	COG0589	response to stress
RA8CHR_01366	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RA8CHR_01369	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_01370	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_01375	COG2832	Protein of unknown function (DUF454)
RA8CHR_01382	COG0583	DNA-binding transcription factor activity
RA8CHR_01384	COG0346	lactoylglutathione lyase activity
RA8CHR_01385	COG0655	NAD(P)H dehydrogenase (quinone) activity
RA8CHR_01389	COG0154	amidase activity
RA8CHR_01392	COG2376	Dihydroxyacetone kinase
RA8CHR_01393	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01394	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA8CHR_01396	COG2207	Transcriptional regulator
RA8CHR_01397	COG2197	response regulator
RA8CHR_01402	COG2208	phosphoserine phosphatase activity
RA8CHR_01413	COG3038	cytochrome b561
RA8CHR_01414	COG2814	Major facilitator Superfamily
RA8CHR_01415	COG0583	DNA-binding transcription factor activity
RA8CHR_01417	COG3468	outer membrane autotransporter barrel domain protein
RA8CHR_01418	COG1640	4-alpha-glucanotransferase
RA8CHR_01419	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RA8CHR_01421	COG0668	transmembrane transport
RA8CHR_01422	COG0366	Alpha amylase catalytic
RA8CHR_01423	COG0366	Alpha amylase catalytic
RA8CHR_01424	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RA8CHR_01431	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_01435	COG0189	ligase activity
RA8CHR_01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RA8CHR_01436	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RA8CHR_01436	COG0189	ligase activity
RA8CHR_01437	COG1132	(ABC) transporter
RA8CHR_01439	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RA8CHR_01440	COG4178	(ABC) transporter
RA8CHR_01455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RA8CHR_01457	COG1765	OsmC-like protein
RA8CHR_01458	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RA8CHR_01460	COG0747	negative chemotaxis
RA8CHR_01462	COG1473	amidohydrolase
RA8CHR_01463	COG4166	transmembrane transport
RA8CHR_01464	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA8CHR_01465	COG0444	Belongs to the ABC transporter superfamily
RA8CHR_01466	COG4608	Belongs to the ABC transporter superfamily
RA8CHR_01467	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RA8CHR_01470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RA8CHR_01471	COG0166	Belongs to the GPI family
RA8CHR_01472	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_01474	COG0459	protein refolding
RA8CHR_01475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RA8CHR_01478	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_01481	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RA8CHR_01485	COG0604	alcohol dehydrogenase
RA8CHR_01485	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_01485	COG3321	synthase
RA8CHR_01495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA8CHR_01496	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RA8CHR_01505	COG4772	TonB-dependent receptor
RA8CHR_01507	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RA8CHR_01509	COG1560	Kdo2-lipid A biosynthetic process
RA8CHR_01510	COG2267	carboxylic ester hydrolase activity
RA8CHR_01511	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RA8CHR_01513	COG1333	cytochrome c biogenesis protein
RA8CHR_01514	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RA8CHR_01515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RA8CHR_01516	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RA8CHR_01518	COG1965	Belongs to the frataxin family
RA8CHR_01525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RA8CHR_01527	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RA8CHR_01532	COG0069	glutamate synthase activity
RA8CHR_01532	COG0067	glutamate synthase
RA8CHR_01532	COG0070	glutamate synthase
RA8CHR_01534	COG1127	ABC transporter
RA8CHR_01535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RA8CHR_01536	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RA8CHR_01537	COG2853	Lipoprotein
RA8CHR_01540	COG1131	(ABC) transporter
RA8CHR_01541	COG0842	Transport permease protein
RA8CHR_01542	COG5007	Belongs to the BolA IbaG family
RA8CHR_01543	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RA8CHR_01544	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RA8CHR_01547	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RA8CHR_01548	COG0131	Imidazoleglycerol-phosphate dehydratase
RA8CHR_01550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RA8CHR_01551	COG3468	outer membrane autotransporter barrel domain protein
RA8CHR_01553	COG0107	imidazoleglycerol-phosphate synthase activity
RA8CHR_01554	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RA8CHR_01555	COG0140	phosphoribosyl-ATP diphosphatase activity
RA8CHR_01557	COG0537	adenosine 5'-monophosphoramidase activity
RA8CHR_01558	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RA8CHR_01559	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RA8CHR_01560	COG0805	protein transport
RA8CHR_01561	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_01562	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RA8CHR_01563	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RA8CHR_01564	COG1970	mechanosensitive ion channel activity
RA8CHR_01565	COG0723	plastoquinol--plastocyanin reductase activity
RA8CHR_01566	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RA8CHR_01567	COG2857	Cytochrome c1
RA8CHR_01568	COG0625	glutathione transferase activity
RA8CHR_01569	COG2969	positive regulation of protein catabolic process
RA8CHR_01571	COG1335	isochorismatase
RA8CHR_01572	COG2309	aminopeptidase activity
RA8CHR_01573	COG0596	Alpha beta hydrolase
RA8CHR_01574	COG3473	Maleate cis-trans isomerase
RA8CHR_01576	COG1741	Belongs to the pirin family
RA8CHR_01578	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
RA8CHR_01582	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RA8CHR_01584	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RA8CHR_01588	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA8CHR_01590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_01597	COG0653	protein targeting
RA8CHR_01600	COG0494	nUDIX hydrolase
RA8CHR_01601	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RA8CHR_01602	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RA8CHR_01604	COG1696	Membrane protein involved in D-alanine export
RA8CHR_01606	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RA8CHR_01610	COG0438	transferase activity, transferring glycosyl groups
RA8CHR_01614	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RA8CHR_01620	COG0463	Glycosyl transferase, family 2
RA8CHR_01621	COG0165	Argininosuccinate lyase
RA8CHR_01622	COG3275	phosphorelay sensor kinase activity
RA8CHR_01627	COG0477	Major facilitator Superfamily
RA8CHR_01630	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
RA8CHR_01634	COG4948	Mandelate Racemase Muconate Lactonizing
RA8CHR_01640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RA8CHR_01643	COG1737	Transcriptional regulator
RA8CHR_01645	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_01648	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RA8CHR_01649	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RA8CHR_01650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_01652	COG2721	sulfolactate sulfo-lyase activity
RA8CHR_01653	COG4948	Mandelate Racemase Muconate Lactonizing
RA8CHR_01662	COG1737	Transcriptional regulator
RA8CHR_01663	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RA8CHR_01671	COG2801	Transposase and inactivated derivatives
RA8CHR_01672	COG2963	transposase activity
RA8CHR_01675	COG1196	nuclear chromosome segregation
RA8CHR_01676	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RA8CHR_01678	COG0732	type I restriction modification DNA specificity domain
RA8CHR_01679	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RA8CHR_01689	COG0142	geranyltranstransferase activity
RA8CHR_01690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RA8CHR_01691	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RA8CHR_01692	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RA8CHR_01693	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RA8CHR_01695	COG0494	nUDIX hydrolase
RA8CHR_01696	COG0442	prolyl-tRNA aminoacylation
RA8CHR_01697	COG0741	lytic transglycosylase activity
RA8CHR_01698	COG1253	flavin adenine dinucleotide binding
RA8CHR_01699	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RA8CHR_01701	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RA8CHR_01702	COG2890	protein-(glutamine-N5) methyltransferase activity
RA8CHR_01703	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RA8CHR_01704	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RA8CHR_01706	COG1196	nuclear chromosome segregation
RA8CHR_01706	COG3264	Mechanosensitive ion channel
RA8CHR_01707	COG0584	glycerophosphoryl diester phosphodiesterase
RA8CHR_01708	COG3842	ATPase activity
RA8CHR_01709	COG0395	ABC-type sugar transport system, permease component
RA8CHR_01710	COG1175	transmembrane transport
RA8CHR_01712	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA8CHR_01716	COG2226	methyltransferase
RA8CHR_01719	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RA8CHR_01720	COG4145	pantothenate transmembrane transporter activity
RA8CHR_01723	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RA8CHR_01725	COG3568	Endonuclease Exonuclease Phosphatase
RA8CHR_01726	COG0302	gtp cyclohydrolase
RA8CHR_01734	COG5487	UPF0391 membrane protein
RA8CHR_01735	COG4585	Histidine kinase
RA8CHR_01736	COG2197	response regulator
RA8CHR_01739	COG2982	Protein involved in outer membrane biogenesis
RA8CHR_01740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RA8CHR_01741	COG0793	Belongs to the peptidase S41A family
RA8CHR_01742	COG0588	phosphoglycerate mutase activity
RA8CHR_01743	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RA8CHR_01744	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RA8CHR_01745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RA8CHR_01746	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RA8CHR_01748	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RA8CHR_01750	COG0720	synthase
RA8CHR_01751	COG0602	queuosine metabolic process
RA8CHR_01752	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RA8CHR_01753	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RA8CHR_01754	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RA8CHR_01755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RA8CHR_01759	COG0659	secondary active sulfate transmembrane transporter activity
RA8CHR_01761	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RA8CHR_01761	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RA8CHR_01762	COG3132	Protein of unknown function, DUF480
RA8CHR_01763	COG0489	protein tyrosine kinase activity
RA8CHR_01764	COG0583	DNA-binding transcription factor activity
RA8CHR_01767	COG3383	formate dehydrogenase (NAD+) activity
RA8CHR_01773	COG0243	molybdopterin cofactor binding
RA8CHR_01773	COG3383	formate dehydrogenase (NAD+) activity
RA8CHR_01774	COG0437	4 iron, 4 sulfur cluster binding
RA8CHR_01779	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RA8CHR_01781	COG0626	cystathionine gamma-synthase activity
RA8CHR_01783	COG0247	lactate metabolic process
RA8CHR_01784	COG1592	Rubrerythrin
RA8CHR_01785	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
RA8CHR_01791	COG2003	Belongs to the UPF0758 family
RA8CHR_01792	COG1047	Peptidyl-prolyl cis-trans
RA8CHR_01793	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RA8CHR_01794	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RA8CHR_01796	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RA8CHR_01805	COG2072	flavoprotein involved in K transport
RA8CHR_01807	COG0438	transferase activity, transferring glycosyl groups
RA8CHR_01808	COG2144	transferase activity, transferring acyl groups
RA8CHR_01813	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_01814	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_01815	COG2239	Acts as a magnesium transporter
RA8CHR_01817	COG2902	Dehydrogenase
RA8CHR_01819	COG5002	protein histidine kinase activity
RA8CHR_01821	COG0180	Tryptophanyl-tRNA synthetase
RA8CHR_01822	COG1994	Peptidase M50
RA8CHR_01823	COG0009	L-threonylcarbamoyladenylate synthase
RA8CHR_01825	COG0613	PHP domain protein
RA8CHR_01841	COG1126	abc transporter atp-binding protein
RA8CHR_01844	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA8CHR_01849	COG0477	Major facilitator Superfamily
RA8CHR_01850	COG0829	nickel cation binding
RA8CHR_01854	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_01856	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_01857	COG1024	Enoyl-CoA hydratase
RA8CHR_01859	COG1024	Enoyl-CoA hydratase
RA8CHR_01860	COG1802	Transcriptional regulator
RA8CHR_01861	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_01862	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_01863	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA8CHR_01863	COG1024	Enoyl-CoA hydratase
RA8CHR_01864	COG0183	Belongs to the thiolase family
RA8CHR_01873	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_01874	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_01877	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01884	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_01886	COG0655	NAD(P)H dehydrogenase (quinone) activity
RA8CHR_01898	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01899	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RA8CHR_01900	COG0583	DNA-binding transcription factor activity
RA8CHR_01906	COG0515	serine threonine protein kinase
RA8CHR_01906	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RA8CHR_01910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_01911	COG1283	sodium-dependent phosphate transmembrane transporter activity
RA8CHR_01912	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_01914	COG0583	DNA-binding transcription factor activity
RA8CHR_01917	COG0392	lysyltransferase activity
RA8CHR_01921	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_01922	COG1116	anion transmembrane transporter activity
RA8CHR_01926	COG0281	malic enzyme
RA8CHR_01926	COG0280	phosphate acetyltransferase
RA8CHR_01932	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RA8CHR_01934	COG3128	pkhd-type hydroxylase
RA8CHR_01937	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RA8CHR_01942	COG4948	Mandelate Racemase Muconate Lactonizing
RA8CHR_01943	COG0583	DNA-binding transcription factor activity
RA8CHR_01944	COG2205	protein histidine kinase activity
RA8CHR_01949	COG3665	Urea carboxylase-associated protein
RA8CHR_01954	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA8CHR_01956	COG1609	Transcriptional regulator
RA8CHR_01958	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RA8CHR_01959	COG0066	3-isopropylmalate dehydratase activity
RA8CHR_01965	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_01966	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_01978	COG0583	DNA-binding transcription factor activity
RA8CHR_01980	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_01981	COG4608	Belongs to the ABC transporter superfamily
RA8CHR_01982	COG0444	Belongs to the ABC transporter superfamily
RA8CHR_01983	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA8CHR_01992	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_01994	COG4521	taurine ABC transporter
RA8CHR_01995	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RA8CHR_01996	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_01997	COG0625	glutathione transferase activity
RA8CHR_01998	COG0477	Major facilitator Superfamily
RA8CHR_02000	COG1414	Transcriptional regulator
RA8CHR_02005	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_02015	COG0583	DNA-binding transcription factor activity
RA8CHR_02017	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_02018	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_02025	COG4964	Belongs to the GSP D family
RA8CHR_02036	COG2197	response regulator
RA8CHR_02037	COG4585	Histidine kinase
RA8CHR_02040	COG1414	Transcriptional regulator
RA8CHR_02043	COG0583	DNA-binding transcription factor activity
RA8CHR_02044	COG0243	molybdopterin cofactor binding
RA8CHR_02045	COG0437	4 iron, 4 sulfur cluster binding
RA8CHR_02046	COG3302	dmso reductase anchor subunit
RA8CHR_02050	COG2226	methyltransferase
RA8CHR_02054	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_02060	COG0640	Transcriptional regulator
RA8CHR_02064	COG2304	oxidoreductase activity
RA8CHR_02068	COG0583	DNA-binding transcription factor activity
RA8CHR_02070	COG0154	amidase activity
RA8CHR_02074	COG1815	bacterial-type flagellum-dependent cell motility
RA8CHR_02075	COG1558	bacterial-type flagellum-dependent cell motility
RA8CHR_02077	COG1749	Flagellar hook protein flgE
RA8CHR_02080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RA8CHR_02081	COG1706	bacterial-type flagellum-dependent cell motility
RA8CHR_02082	COG3951	Flagellar rod assembly protein muramidase FlgJ
RA8CHR_02082	COG1705	Flagellar rod assembly protein muramidase FlgJ
RA8CHR_02083	COG0835	chemotaxis
RA8CHR_02084	COG0840	transmembrane signaling receptor activity
RA8CHR_02085	COG0835	chemotaxis
RA8CHR_02088	COG0840	transmembrane signaling receptor activity
RA8CHR_02089	COG1256	bacterial-type flagellum assembly
RA8CHR_02092	COG2020	methyltransferase activity
RA8CHR_02093	COG2267	carboxylic ester hydrolase activity
RA8CHR_02095	COG0432	Pfam Uncharacterised protein family UPF0047
RA8CHR_02106	COG0745	RESPONSE REGULATOR receiver
RA8CHR_02107	COG1764	response to oxidative stress
RA8CHR_02109	COG0583	DNA-binding transcription factor activity
RA8CHR_02110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_02113	COG1024	Enoyl-CoA hydratase
RA8CHR_02115	COG0183	Belongs to the thiolase family
RA8CHR_02118	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RA8CHR_02119	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RA8CHR_02122	COG1845	cytochrome c oxidase, subunit III
RA8CHR_02130	COG1338	Plays a role in the flagellum-specific transport system
RA8CHR_02132	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RA8CHR_02133	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RA8CHR_02134	COG1580	Controls the rotational direction of flagella during chemotaxis
RA8CHR_02135	COG3144	bacterial-type flagellum assembly
RA8CHR_02137	COG1157	protein secretion by the type III secretion system
RA8CHR_02138	COG1317	bacterial-type flagellum organization
RA8CHR_02139	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RA8CHR_02140	COG1766	The M ring may be actively involved in energy transduction
RA8CHR_02141	COG1677	Flagellar hook-basal body complex protein FliE
RA8CHR_02143	COG1334	flagellar protein FlaG
RA8CHR_02144	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RA8CHR_02148	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RA8CHR_02153	COG2198	Histidine kinase
RA8CHR_02153	COG0643	Histidine kinase
RA8CHR_02154	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RA8CHR_02155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RA8CHR_02157	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RA8CHR_02160	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RA8CHR_02168	COG1191	sigma factor activity
RA8CHR_02172	COG1716	ATPase activity
RA8CHR_02176	COG2801	Transposase and inactivated derivatives
RA8CHR_02177	COG2963	transposase activity
RA8CHR_02179	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RA8CHR_02180	COG0308	aminopeptidase N
RA8CHR_02181	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RA8CHR_02182	COG2267	carboxylic ester hydrolase activity
RA8CHR_02183	COG0667	Aldo Keto reductase
RA8CHR_02184	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RA8CHR_02185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RA8CHR_02186	COG0251	oxidation-reduction process
RA8CHR_02188	COG1666	GTP binding
RA8CHR_02189	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RA8CHR_02190	COG0137	argininosuccinate synthase activity
RA8CHR_02191	COG3123	guanosine phosphorylase activity
RA8CHR_02193	COG1393	Belongs to the ArsC family
RA8CHR_02194	COG0285	dihydrofolate synthase activity
RA8CHR_02199	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RA8CHR_02204	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_02205	COG0183	Belongs to the thiolase family
RA8CHR_02207	COG0583	DNA-binding transcription factor activity
RA8CHR_02208	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RA8CHR_02212	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RA8CHR_02214	COG2252	PERMEase
RA8CHR_02220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RA8CHR_02224	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RA8CHR_02225	COG2200	EAL domain
RA8CHR_02225	COG3287	FIST C domain
RA8CHR_02225	COG2199	diguanylate cyclase activity
RA8CHR_02229	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_02230	COG0717	Belongs to the dCTP deaminase family
RA8CHR_02231	COG2321	neutral zinc metallopeptidase
RA8CHR_02232	COG0513	Belongs to the DEAD box helicase family
RA8CHR_02233	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RA8CHR_02234	COG1253	flavin adenine dinucleotide binding
RA8CHR_02237	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02243	COG2084	Dehydrogenase
RA8CHR_02244	COG3622	Belongs to the hyi family
RA8CHR_02245	COG3960	tartronate-semialdehyde synthase activity
RA8CHR_02246	COG0583	DNA-binding transcription factor activity
RA8CHR_02247	COG0840	transmembrane signaling receptor activity
RA8CHR_02257	COG2186	Transcriptional regulator
RA8CHR_02258	COG1301	dicarboxylic acid transport
RA8CHR_02270	COG3246	L-lysine catabolic process to acetate
RA8CHR_02271	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_02277	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_02278	COG0625	glutathione transferase activity
RA8CHR_02280	COG1902	pentaerythritol trinitrate reductase activity
RA8CHR_02282	COG0583	DNA-binding transcription factor activity
RA8CHR_02283	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA8CHR_02286	COG1538	Outer membrane efflux protein
RA8CHR_02287	COG1902	pentaerythritol trinitrate reductase activity
RA8CHR_02296	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RA8CHR_02302	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_02305	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02308	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RA8CHR_02309	COG4948	Mandelate Racemase Muconate Lactonizing
RA8CHR_02310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA8CHR_02311	COG4948	Mandelate Racemase Muconate Lactonizing
RA8CHR_02316	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_02318	COG1473	amidohydrolase
RA8CHR_02319	COG1522	sequence-specific DNA binding
RA8CHR_02320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RA8CHR_02325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_02326	COG4166	transmembrane transport
RA8CHR_02327	COG0601	transmembrane transport
RA8CHR_02328	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA8CHR_02330	COG0473	3-isopropylmalate dehydrogenase activity
RA8CHR_02331	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_02332	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_02335	COG3119	arylsulfatase activity
RA8CHR_02336	COG0583	DNA-binding transcription factor activity
RA8CHR_02337	COG0277	FAD linked oxidase domain protein
RA8CHR_02341	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
RA8CHR_02342	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_02343	COG2301	Belongs to the HpcH HpaI aldolase family
RA8CHR_02345	COG0583	DNA-binding transcription factor activity
RA8CHR_02347	COG2828	Protein conserved in bacteria
RA8CHR_02349	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_02350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RA8CHR_02351	COG1609	Transcriptional regulator
RA8CHR_02352	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA8CHR_02354	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_02355	COG0589	response to stress
RA8CHR_02363	COG0071	Belongs to the small heat shock protein (HSP20) family
RA8CHR_02365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RA8CHR_02366	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_02368	COG0574	Belongs to the PEP-utilizing enzyme family
RA8CHR_02368	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RA8CHR_02369	COG0589	response to stress
RA8CHR_02372	COG1136	(ABC) transporter
RA8CHR_02375	COG0392	lysyltransferase activity
RA8CHR_02381	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_02384	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RA8CHR_02385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RA8CHR_02386	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA8CHR_02386	COG0022	dehydrogenase e1 component
RA8CHR_02388	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RA8CHR_02389	COG2116	formate transmembrane transporter activity
RA8CHR_02391	COG0183	Belongs to the thiolase family
RA8CHR_02392	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RA8CHR_02394	COG4876	unkown
RA8CHR_02396	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RA8CHR_02397	COG0459	protein refolding
RA8CHR_02406	COG0542	response to heat
RA8CHR_02407	COG0058	SHG alpha-glucan phosphorylase activity
RA8CHR_02410	COG0642	Histidine kinase
RA8CHR_02414	COG1022	Amp-dependent synthetase and ligase
RA8CHR_02417	COG1136	(ABC) transporter
RA8CHR_02418	COG4591	ABC-type transport system involved in lipoprotein release permease component
RA8CHR_02420	COG5002	protein histidine kinase activity
RA8CHR_02420	COG2176	DNA-directed DNA polymerase activity
RA8CHR_02421	COG0745	RESPONSE REGULATOR receiver
RA8CHR_02425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA8CHR_02426	COG3162	membrane
RA8CHR_02432	COG3850	Histidine kinase
RA8CHR_02433	COG2197	response regulator
RA8CHR_02436	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RA8CHR_02437	COG1140	nitrate reductase beta subunit
RA8CHR_02438	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RA8CHR_02439	COG2181	nitrate reductase activity
RA8CHR_02440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RA8CHR_02446	COG0589	response to stress
RA8CHR_02459	COG0745	RESPONSE REGULATOR receiver
RA8CHR_02461	COG2205	protein histidine kinase activity
RA8CHR_02467	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RA8CHR_02468	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RA8CHR_02469	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RA8CHR_02470	COG2080	2 iron, 2 sulfur cluster binding
RA8CHR_02472	COG2814	Major facilitator Superfamily
RA8CHR_02474	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RA8CHR_02475	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02477	COG0583	DNA-binding transcription factor activity
RA8CHR_02482	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02486	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02488	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02490	COG0656	L-ascorbic acid biosynthetic process
RA8CHR_02491	COG2233	PERMEase
RA8CHR_02495	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02496	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RA8CHR_02498	COG3754	Rhamnan synthesis protein F
RA8CHR_02499	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA8CHR_02502	COG2186	Transcriptional regulator
RA8CHR_02503	COG2351	hydroxyisourate hydrolase activity
RA8CHR_02510	COG1131	(ABC) transporter
RA8CHR_02511	COG0842	Transport permease protein
RA8CHR_02512	COG0842	Transport permease protein
RA8CHR_02519	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RA8CHR_02519	COG0674	pyruvate-flavodoxin oxidoreductase activity
RA8CHR_02521	COG1733	regulation of RNA biosynthetic process
RA8CHR_02526	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_02527	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RA8CHR_02529	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02535	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02543	COG2815	serine threonine protein kinase
RA8CHR_02543	COG0515	serine threonine protein kinase
RA8CHR_02566	COG2217	Heavy metal translocating P-type atpase
RA8CHR_02567	COG0789	Transcriptional regulator
RA8CHR_02568	COG2010	Cytochrome c
RA8CHR_02568	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RA8CHR_02571	COG0697	spore germination
RA8CHR_02573	COG2169	Transcriptional regulator
RA8CHR_02583	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RA8CHR_02586	COG1309	transcriptional regulator
RA8CHR_02587	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RA8CHR_02591	COG1181	Belongs to the D-alanine--D-alanine ligase family
RA8CHR_02592	COG0527	aspartate kinase activity
RA8CHR_02593	COG0667	Aldo Keto reductase
RA8CHR_02594	COG0583	DNA-binding transcription factor activity
RA8CHR_02599	COG0800	Aldolase
RA8CHR_02601	COG0346	lactoylglutathione lyase activity
RA8CHR_02602	COG3842	ATPase activity
RA8CHR_02604	COG1840	ABC-type Fe3 transport system, periplasmic component
RA8CHR_02605	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_02606	COG2070	2-Nitropropane dioxygenase
RA8CHR_02607	COG4221	oxidoreductase activity
RA8CHR_02612	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_02615	COG1609	Transcriptional regulator
RA8CHR_02619	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_02620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_02621	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA8CHR_02631	COG0800	Aldolase
RA8CHR_02633	COG0129	dihydroxy-acid dehydratase activity
RA8CHR_02634	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA8CHR_02635	COG2186	Transcriptional regulator
RA8CHR_02637	COG1175	transmembrane transport
RA8CHR_02639	COG3842	ATPase activity
RA8CHR_02640	COG0513	Belongs to the DEAD box helicase family
RA8CHR_02642	COG0488	(ABC) transporter
RA8CHR_02643	COG2133	pyrroloquinoline quinone binding
RA8CHR_02648	COG3191	aminopeptidase activity
RA8CHR_02650	COG0789	Transcriptional regulator
RA8CHR_02651	COG0584	glycerophosphoryl diester phosphodiesterase
RA8CHR_02654	COG0765	amino acid transport
RA8CHR_02656	COG0765	amino acid transport
RA8CHR_02659	COG1764	response to oxidative stress
RA8CHR_02660	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_02666	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RA8CHR_02667	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RA8CHR_02670	COG0589	response to stress
RA8CHR_02671	COG0564	pseudouridine synthase activity
RA8CHR_02676	COG2354	Protein conserved in bacteria
RA8CHR_02677	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RA8CHR_02679	COG3468	outer membrane autotransporter barrel domain protein
RA8CHR_02682	COG0400	carboxylic ester hydrolase activity
RA8CHR_02683	COG2918	glutathione biosynthetic process
RA8CHR_02684	COG2423	ornithine cyclodeaminase activity
RA8CHR_02687	COG0789	Transcriptional regulator
RA8CHR_02688	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RA8CHR_02690	COG3279	Response regulator of the LytR AlgR family
RA8CHR_02691	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RA8CHR_02700	COG2175	clavaminate synthase activity
RA8CHR_02707	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RA8CHR_02709	COG3279	Response regulator of the LytR AlgR family
RA8CHR_02710	COG3275	phosphorelay sensor kinase activity
RA8CHR_02719	COG1968	undecaprenyl-diphosphatase activity
RA8CHR_02724	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RA8CHR_02726	COG3119	arylsulfatase activity
RA8CHR_02729	COG1846	Transcriptional regulator
RA8CHR_02730	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02731	COG0583	DNA-binding transcription factor activity
RA8CHR_02733	COG1289	transmembrane transporter activity
RA8CHR_02736	COG1045	serine acetyltransferase
RA8CHR_02737	COG0521	Mo-molybdopterin cofactor biosynthetic process
RA8CHR_02739	COG0312	modulator of DNA gyrase
RA8CHR_02741	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RA8CHR_02742	COG2081	HI0933 family
RA8CHR_02745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RA8CHR_02746	COG0243	molybdopterin cofactor binding
RA8CHR_02748	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RA8CHR_02750	COG2223	nitrite transmembrane transporter activity
RA8CHR_02752	COG1116	anion transmembrane transporter activity
RA8CHR_02753	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_02754	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA8CHR_02755	COG3707	response regulator
RA8CHR_02756	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RA8CHR_02758	COG0071	Belongs to the small heat shock protein (HSP20) family
RA8CHR_02759	COG0683	leucine binding
RA8CHR_02760	COG0436	Aminotransferase
RA8CHR_02761	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RA8CHR_02762	COG1185	polyribonucleotide nucleotidyltransferase activity
RA8CHR_02764	COG0149	triose-phosphate isomerase activity
RA8CHR_02767	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RA8CHR_02768	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RA8CHR_02769	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RA8CHR_02770	COG0649	NAD binding
RA8CHR_02771	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RA8CHR_02774	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RA8CHR_02775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RA8CHR_02777	COG0713	ATP synthesis coupled electron transport
RA8CHR_02780	COG1007	ATP synthesis coupled electron transport
RA8CHR_02783	COG0494	nUDIX hydrolase
RA8CHR_02785	COG1132	(ABC) transporter
RA8CHR_02786	COG1846	Transcriptional regulator
RA8CHR_02788	COG1566	PFAM secretion protein HlyD family protein
RA8CHR_02789	COG2814	Major facilitator Superfamily
RA8CHR_02801	COG0154	amidase activity
RA8CHR_02803	COG0477	Major facilitator Superfamily
RA8CHR_02805	COG1215	transferase activity, transferring glycosyl groups
RA8CHR_02811	COG2194	sulfuric ester hydrolase activity
RA8CHR_02813	COG0154	amidase activity
RA8CHR_02814	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_02815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RA8CHR_02816	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA8CHR_02816	COG3321	synthase
RA8CHR_02816	COG0604	alcohol dehydrogenase
RA8CHR_02816	COG4221	oxidoreductase activity
RA8CHR_02818	COG0583	DNA-binding transcription factor activity
RA8CHR_02820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RA8CHR_02828	COG2186	Transcriptional regulator
RA8CHR_02831	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_02834	COG1136	(ABC) transporter
RA8CHR_02835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RA8CHR_02836	COG2814	Major facilitator Superfamily
RA8CHR_02838	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RA8CHR_02839	COG0586	Pfam SNARE associated Golgi protein
RA8CHR_02842	COG0860	N-Acetylmuramoyl-L-alanine amidase
RA8CHR_02843	COG0802	atpase or kinase
RA8CHR_02844	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RA8CHR_02847	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_02848	COG4974	Belongs to the 'phage' integrase family
RA8CHR_02855	COG2833	Protein of unknown function (DUF455)
RA8CHR_02857	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RA8CHR_02860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RA8CHR_02861	COG0148	phosphopyruvate hydratase activity
RA8CHR_02863	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RA8CHR_02864	COG0504	CTP synthase activity
RA8CHR_02865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RA8CHR_02867	COG0756	dUTP diphosphatase activity
RA8CHR_02870	COG1047	Peptidyl-prolyl cis-trans
RA8CHR_02871	COG2850	peptidyl-arginine hydroxylation
RA8CHR_02874	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RA8CHR_02875	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RA8CHR_02876	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA8CHR_02883	COG0741	lytic transglycosylase activity
RA8CHR_02891	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RA8CHR_02893	COG0765	amino acid transport
RA8CHR_02894	COG0765	amino acid transport
RA8CHR_02896	COG1126	abc transporter atp-binding protein
RA8CHR_02898	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA8CHR_02900	COG1609	Transcriptional regulator
RA8CHR_02902	COG1487	ribonuclease activity
RA8CHR_02904	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_02905	COG1522	sequence-specific DNA binding
RA8CHR_02911	COG2308	Evidence 4 Homologs of previously reported genes of
RA8CHR_02913	COG2274	protein secretion by the type I secretion system
RA8CHR_02917	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RA8CHR_02921	COG3842	ATPase activity
RA8CHR_02924	COG0395	ABC-type sugar transport system, permease component
RA8CHR_02929	COG2951	lytic endotransglycosylase activity
RA8CHR_02932	COG0714	Associated with various cellular activities
RA8CHR_02934	COG3264	Mechanosensitive ion channel
RA8CHR_02934	COG1511	domain protein
RA8CHR_02937	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_02941	COG4988	ABC transporter
RA8CHR_02942	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RA8CHR_02943	COG1271	oxidase subunit
RA8CHR_02944	COG1294	oxidase, subunit
RA8CHR_02946	COG4251	negative regulation of phosphorylation
RA8CHR_02947	COG0784	Response regulator, receiver
RA8CHR_02948	COG0784	Response regulator, receiver
RA8CHR_02948	COG4191	Histidine kinase
RA8CHR_02952	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RA8CHR_02954	COG0477	Major facilitator Superfamily
RA8CHR_02957	COG1414	Transcriptional regulator
RA8CHR_02958	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RA8CHR_02960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RA8CHR_02968	COG0583	DNA-binding transcription factor activity
RA8CHR_02969	COG0477	Major facilitator Superfamily
RA8CHR_02972	COG4941	Belongs to the sigma-70 factor family
RA8CHR_02973	COG3795	YCII-related domain
RA8CHR_02976	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RA8CHR_02978	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RA8CHR_02978	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RA8CHR_02979	COG0509	glycine decarboxylation via glycine cleavage system
RA8CHR_02980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RA8CHR_02985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_02986	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA8CHR_02987	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA8CHR_02987	COG2205	protein histidine kinase activity
RA8CHR_02989	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_02993	COG0642	Histidine kinase
RA8CHR_02994	COG0745	RESPONSE REGULATOR receiver
RA8CHR_02996	COG2194	sulfuric ester hydrolase activity
RA8CHR_02998	COG4302	ethanolamine ammonia-lyase activity
RA8CHR_02999	COG4303	Ethanolamine ammonia lyase large subunit
RA8CHR_03000	COG0545	Peptidyl-prolyl cis-trans isomerase
RA8CHR_03002	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RA8CHR_03003	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RA8CHR_03003	COG2169	Transcriptional regulator
RA8CHR_03005	COG3145	DNA-N1-methyladenine dioxygenase activity
RA8CHR_03007	COG2197	response regulator
RA8CHR_03010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_03016	COG1024	Enoyl-CoA hydratase
RA8CHR_03018	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RA8CHR_03023	COG0406	alpha-ribazole phosphatase activity
RA8CHR_03024	COG2909	trisaccharide binding
RA8CHR_03025	COG2197	response regulator
RA8CHR_03026	COG2909	trisaccharide binding
RA8CHR_03026	COG2909	trisaccharide binding
RA8CHR_03027	COG2909	trisaccharide binding
RA8CHR_03027	COG2909	trisaccharide binding
RA8CHR_03028	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_03029	COG1183	phosphatidylcholine synthase activity
RA8CHR_03030	COG1160	GTP binding
RA8CHR_03033	COG1132	(ABC) transporter
RA8CHR_03034	COG3384	dioxygenase
RA8CHR_03062	COG0587	DNA-directed DNA polymerase activity
RA8CHR_03066	COG1309	transcriptional regulator
RA8CHR_03075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RA8CHR_03076	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RA8CHR_03078	COG2116	formate transmembrane transporter activity
RA8CHR_03081	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RA8CHR_03086	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RA8CHR_03088	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_03089	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RA8CHR_03093	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03095	COG2267	carboxylic ester hydrolase activity
RA8CHR_03096	COG1414	Transcriptional regulator
RA8CHR_03098	COG0028	Belongs to the TPP enzyme family
RA8CHR_03099	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RA8CHR_03100	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_03103	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_03115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RA8CHR_03118	COG0084	hydrolase, TatD family'
RA8CHR_03121	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RA8CHR_03122	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RA8CHR_03124	COG2879	small protein
RA8CHR_03125	COG1966	Carbon starvation protein
RA8CHR_03134	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_03135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA8CHR_03145	COG2183	response to ionizing radiation
RA8CHR_03149	COG2084	Dehydrogenase
RA8CHR_03150	COG0583	DNA-binding transcription factor activity
RA8CHR_03151	COG0583	DNA-binding transcription factor activity
RA8CHR_03156	COG0534	Mate efflux family protein
RA8CHR_03161	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RA8CHR_03164	COG0477	Major facilitator Superfamily
RA8CHR_03165	COG2814	Major facilitator Superfamily
RA8CHR_03166	COG2814	Major facilitator Superfamily
RA8CHR_03169	COG1063	alcohol dehydrogenase
RA8CHR_03175	COG3008	intermembrane lipid transfer
RA8CHR_03175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RA8CHR_03176	COG2995	paraquat-inducible protein a
RA8CHR_03177	COG2995	paraquat-inducible protein a
RA8CHR_03178	COG0583	DNA-binding transcription factor activity
RA8CHR_03179	COG2814	Major facilitator Superfamily
RA8CHR_03180	COG0667	Aldo Keto reductase
RA8CHR_03181	COG0745	RESPONSE REGULATOR receiver
RA8CHR_03184	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RA8CHR_03186	COG5507	3-demethylubiquinone-9 3-methyltransferase
RA8CHR_03190	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_03191	COG2130	NADP-dependent
RA8CHR_03195	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_03196	COG0183	Belongs to the thiolase family
RA8CHR_03197	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA8CHR_03198	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA8CHR_03198	COG1024	Enoyl-CoA hydratase
RA8CHR_03200	COG0411	ABC transporter
RA8CHR_03202	COG0559	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_03204	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_03205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RA8CHR_03206	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RA8CHR_03207	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RA8CHR_03208	COG2917	probably involved in intracellular septation
RA8CHR_03210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RA8CHR_03214	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RA8CHR_03214	COG0047	phosphoribosylformylglycinamidine synthase activity
RA8CHR_03215	COG0024	Methionine aminopeptidase
RA8CHR_03216	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RA8CHR_03217	COG2259	Doxx family
RA8CHR_03218	COG0242	peptide deformylase activity
RA8CHR_03220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RA8CHR_03222	COG1196	nuclear chromosome segregation
RA8CHR_03230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RA8CHR_03231	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RA8CHR_03232	COG4208	sulfate ABC transporter
RA8CHR_03234	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RA8CHR_03237	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RA8CHR_03238	COG3550	peptidyl-serine autophosphorylation
RA8CHR_03241	COG1045	serine acetyltransferase
RA8CHR_03242	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RA8CHR_03243	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RA8CHR_03244	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RA8CHR_03244	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_03247	COG0583	DNA-binding transcription factor activity
RA8CHR_03249	COG1272	protein, Hemolysin III
RA8CHR_03256	COG0175	sulfate reduction
RA8CHR_03257	COG2895	sulfate adenylyltransferase (ATP) activity
RA8CHR_03258	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RA8CHR_03259	COG0492	ferredoxin-NADP+ reductase activity
RA8CHR_03260	COG0671	phosphoesterase, PA-phosphatase related
RA8CHR_03262	COG4654	Cytochrome c, class I
RA8CHR_03264	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RA8CHR_03267	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RA8CHR_03268	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_03270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RA8CHR_03271	COG0114	fumarate hydratase activity
RA8CHR_03280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RA8CHR_03281	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RA8CHR_03282	COG0740	serine-type endopeptidase activity
RA8CHR_03283	COG0544	peptidyl-prolyl cis-trans isomerase activity
RA8CHR_03286	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA8CHR_03289	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RA8CHR_03298	COG1011	Hydrolase
RA8CHR_03299	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RA8CHR_03305	COG0411	ABC transporter
RA8CHR_03310	COG2197	response regulator
RA8CHR_03322	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03323	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA8CHR_03324	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_03325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA8CHR_03326	COG0583	DNA-binding transcription factor activity
RA8CHR_03328	COG1024	Enoyl-CoA hydratase
RA8CHR_03330	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_03333	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03336	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_03340	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_03342	COG0642	Histidine kinase
RA8CHR_03344	COG2326	polyphosphate kinase activity
RA8CHR_03346	COG1414	Transcriptional regulator
RA8CHR_03354	COG0037	tRNA processing
RA8CHR_03355	COG0825	malonyl-CoA metabolic process
RA8CHR_03357	COG0215	cysteine-tRNA ligase activity
RA8CHR_03361	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RA8CHR_03362	COG3228	Belongs to the MtfA family
RA8CHR_03365	COG0741	lytic transglycosylase activity
RA8CHR_03366	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RA8CHR_03367	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RA8CHR_03372	COG4968	Prepilin-type N-terminal cleavage methylation domain
RA8CHR_03373	COG4968	Prepilin-type N-terminal cleavage methylation domain
RA8CHR_03374	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RA8CHR_03374	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RA8CHR_03377	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RA8CHR_03378	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RA8CHR_03379	COG0436	Aminotransferase
RA8CHR_03380	COG0824	Thioesterase
RA8CHR_03381	COG0811	peptide transport
RA8CHR_03382	COG0848	biopolymer transport protein
RA8CHR_03386	COG1741	Belongs to the pirin family
RA8CHR_03388	COG2259	Doxx family
RA8CHR_03389	COG1741	Belongs to the pirin family
RA8CHR_03392	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RA8CHR_03393	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RA8CHR_03396	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RA8CHR_03402	COG0235	Class ii aldolase
RA8CHR_03405	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_03408	COG3119	arylsulfatase activity
RA8CHR_03409	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_03410	COG1024	Enoyl-CoA hydratase
RA8CHR_03411	COG0840	transmembrane signaling receptor activity
RA8CHR_03416	COG1619	proteins homologs of microcin C7 resistance protein MccF
RA8CHR_03422	COG4566	intracellular signal transduction
RA8CHR_03423	COG4191	Histidine kinase
RA8CHR_03426	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RA8CHR_03427	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03428	COG3246	L-lysine catabolic process to acetate
RA8CHR_03429	COG0410	ABC transporter
RA8CHR_03430	COG0411	ABC transporter
RA8CHR_03432	COG0559	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_03434	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03436	COG2272	Belongs to the type-B carboxylesterase lipase family
RA8CHR_03439	COG0045	succinate-CoA ligase (ADP-forming) activity
RA8CHR_03439	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA8CHR_03439	COG1042	CoA-binding domain protein
RA8CHR_03440	COG2197	response regulator
RA8CHR_03443	COG0477	Major facilitator Superfamily
RA8CHR_03444	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RA8CHR_03445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RA8CHR_03446	COG1845	cytochrome c oxidase, subunit III
RA8CHR_03447	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RA8CHR_03450	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RA8CHR_03451	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RA8CHR_03454	COG1672	PFAM Archaeal ATPase
RA8CHR_03454	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RA8CHR_03455	COG0583	DNA-binding transcription factor activity
RA8CHR_03456	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_03457	COG1024	Enoyl-CoA hydratase
RA8CHR_03459	COG0519	Catalyzes the synthesis of GMP from XMP
RA8CHR_03459	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RA8CHR_03463	COG2867	negative regulation of translational initiation
RA8CHR_03464	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RA8CHR_03472	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RA8CHR_03473	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RA8CHR_03474	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RA8CHR_03475	COG2251	uridine kinase activity
RA8CHR_03475	COG0195	Participates in both transcription termination and antitermination
RA8CHR_03476	COG0779	Required for maturation of 30S ribosomal subunits
RA8CHR_03477	COG0477	Major facilitator Superfamily
RA8CHR_03478	COG4172	Belongs to the ABC transporter superfamily
RA8CHR_03479	COG4239	(ABC) transporter, permease
RA8CHR_03480	COG4174	ABC transporter (Permease)
RA8CHR_03481	COG4166	transmembrane transport
RA8CHR_03483	COG1793	dna ligase
RA8CHR_03484	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RA8CHR_03485	COG1982	Orn Lys Arg decarboxylase major
RA8CHR_03494	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RA8CHR_03498	COG0583	DNA-binding transcription factor activity
RA8CHR_03499	COG0436	Aminotransferase
RA8CHR_03501	COG1643	Atp-dependent helicase
RA8CHR_03502	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RA8CHR_03502	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RA8CHR_03503	COG0436	Aminotransferase
RA8CHR_03504	COG2171	N-acyltransferase activity
RA8CHR_03506	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA8CHR_03507	COG2890	protein-(glutamine-N5) methyltransferase activity
RA8CHR_03515	COG4670	ketone body catabolic process
RA8CHR_03517	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RA8CHR_03518	COG0673	inositol 2-dehydrogenase activity
RA8CHR_03520	COG1053	succinate dehydrogenase
RA8CHR_03529	COG3618	amidohydrolase
RA8CHR_03532	COG0411	ABC transporter
RA8CHR_03533	COG0559	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_03535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_03536	COG1053	succinate dehydrogenase
RA8CHR_03542	COG1414	Transcriptional regulator
RA8CHR_03544	COG1116	anion transmembrane transporter activity
RA8CHR_03544	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA8CHR_03545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_03548	COG0439	Biotin carboxylase
RA8CHR_03550	COG3246	L-lysine catabolic process to acetate
RA8CHR_03551	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03554	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RA8CHR_03557	COG0823	Involved in the tonB-independent uptake of proteins
RA8CHR_03558	COG1132	(ABC) transporter
RA8CHR_03560	COG1530	ribonuclease E activity
RA8CHR_03561	COG0424	maF-like protein
RA8CHR_03562	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RA8CHR_03563	COG0799	negative regulation of ribosome biogenesis
RA8CHR_03564	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RA8CHR_03565	COG0408	coproporphyrinogen oxidase activity
RA8CHR_03566	COG0151	Belongs to the GarS family
RA8CHR_03567	COG0217	transcriptional regulatory protein
RA8CHR_03572	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03575	COG0726	polysaccharide deacetylase
RA8CHR_03579	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RA8CHR_03582	COG0433	COG0433 Predicted ATPase
RA8CHR_03583	COG4944	Protein of unknown function (DUF1109)
RA8CHR_03584	COG1595	DNA-templated transcription, initiation
RA8CHR_03586	COG3220	belongs to the UPF0276 family
RA8CHR_03591	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RA8CHR_03592	COG1744	ABC transporter substrate-binding protein PnrA-like
RA8CHR_03596	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_03597	COG2925	Exonuclease
RA8CHR_03598	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_03599	COG0542	response to heat
RA8CHR_03600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RA8CHR_03604	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RA8CHR_03605	COG1570	exodeoxyribonuclease VII activity
RA8CHR_03606	COG0811	peptide transport
RA8CHR_03607	COG0848	biopolymer transport protein
RA8CHR_03608	COG1663	tetraacyldisaccharide 4'-kinase activity
RA8CHR_03609	COG2835	tetraacyldisaccharide 4'-kinase activity
RA8CHR_03610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RA8CHR_03611	COG0563	adenylate kinase activity
RA8CHR_03614	COG0252	asparaginase activity
RA8CHR_03615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RA8CHR_03617	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA8CHR_03618	COG2814	Major facilitator Superfamily
RA8CHR_03620	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA8CHR_03621	COG1024	Enoyl-CoA hydratase
RA8CHR_03626	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RA8CHR_03628	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RA8CHR_03629	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RA8CHR_03630	COG1534	Rna-binding protein
RA8CHR_03633	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RA8CHR_03635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RA8CHR_03636	COG0505	Belongs to the CarA family
RA8CHR_03637	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RA8CHR_03638	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RA8CHR_03639	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RA8CHR_03640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RA8CHR_03641	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RA8CHR_03642	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RA8CHR_03645	COG0750	zinc metalloprotease
RA8CHR_03646	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RA8CHR_03647	COG0575	Belongs to the CDS family
RA8CHR_03648	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RA8CHR_03649	COG0233	cytoplasmic translational termination
RA8CHR_03650	COG0528	UMP kinase activity
RA8CHR_03651	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RA8CHR_03652	COG0052	Belongs to the universal ribosomal protein uS2 family
RA8CHR_03654	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_03655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RA8CHR_03655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RA8CHR_03656	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03657	COG0557	exoribonuclease II activity
RA8CHR_03659	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RA8CHR_03660	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RA8CHR_03663	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RA8CHR_03664	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03667	COG0745	RESPONSE REGULATOR receiver
RA8CHR_03668	COG2205	protein histidine kinase activity
RA8CHR_03669	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RA8CHR_03669	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RA8CHR_03670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RA8CHR_03670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RA8CHR_03671	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RA8CHR_03672	COG0560	Phosphoserine phosphatase
RA8CHR_03673	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_03677	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_03678	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RA8CHR_03679	COG2079	MmgE PrpD family protein
RA8CHR_03681	COG1024	Enoyl-CoA hydratase
RA8CHR_03685	COG0596	Alpha beta hydrolase
RA8CHR_03688	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03693	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RA8CHR_03694	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RA8CHR_03695	COG1492	cobalamin metabolic process
RA8CHR_03699	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA8CHR_03702	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RA8CHR_03703	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RA8CHR_03704	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RA8CHR_03705	COG1120	ATPase activity
RA8CHR_03706	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA8CHR_03707	COG4607	ABC-type enterochelin transport system periplasmic component
RA8CHR_03709	COG4206	TonB-dependent receptor
RA8CHR_03713	COG0730	response to heat
RA8CHR_03716	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RA8CHR_03718	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_03722	COG1802	Transcriptional regulator
RA8CHR_03724	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RA8CHR_03725	COG0583	DNA-binding transcription factor activity
RA8CHR_03726	COG0129	dihydroxy-acid dehydratase activity
RA8CHR_03728	COG0351	phosphomethylpyrimidine kinase
RA8CHR_03731	COG2022	thiamine diphosphate biosynthetic process
RA8CHR_03749	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_03750	COG0642	Histidine kinase
RA8CHR_03751	COG0745	RESPONSE REGULATOR receiver
RA8CHR_03752	COG1414	Transcriptional regulator
RA8CHR_03755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RA8CHR_03756	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RA8CHR_03757	COG1414	Transcriptional regulator
RA8CHR_03759	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RA8CHR_03760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RA8CHR_03761	COG1183	phosphatidylcholine synthase activity
RA8CHR_03762	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RA8CHR_03763	COG0440	acetolactate synthase activity
RA8CHR_03764	COG0028	Belongs to the TPP enzyme family
RA8CHR_03771	COG0347	Belongs to the P(II) protein family
RA8CHR_03772	COG0697	spore germination
RA8CHR_03774	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03775	COG1063	alcohol dehydrogenase
RA8CHR_03776	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RA8CHR_03784	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_03788	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA8CHR_03791	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_03796	COG0235	Class ii aldolase
RA8CHR_03798	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_03802	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
RA8CHR_03837	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RA8CHR_03838	COG0746	molybdenum cofactor guanylyltransferase activity
RA8CHR_03841	COG0328	RNA-DNA hybrid ribonuclease activity
RA8CHR_03843	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA8CHR_03844	COG1388	LysM domain
RA8CHR_03844	COG0741	lytic transglycosylase activity
RA8CHR_03845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_03847	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA8CHR_03849	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RA8CHR_03850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RA8CHR_03851	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RA8CHR_03856	COG1074	ATP-dependent DNA helicase activity
RA8CHR_03858	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RA8CHR_03859	COG0673	inositol 2-dehydrogenase activity
RA8CHR_03860	COG0254	rRNA binding
RA8CHR_03862	COG0534	Mate efflux family protein
RA8CHR_03863	COG5002	protein histidine kinase activity
RA8CHR_03866	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RA8CHR_03867	COG0581	inorganic phosphate transmembrane transporter activity
RA8CHR_03868	COG0573	inorganic phosphate transmembrane transporter activity
RA8CHR_03869	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RA8CHR_03870	COG0248	Ppx GppA phosphatase
RA8CHR_03874	COG3634	alkyl hydroperoxide reductase activity
RA8CHR_03875	COG0625	glutathione transferase activity
RA8CHR_03880	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_03881	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
RA8CHR_03883	COG2323	membrane
RA8CHR_03886	COG1024	Enoyl-CoA hydratase
RA8CHR_03888	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03889	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_03890	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_03894	COG0589	response to stress
RA8CHR_03897	COG1846	Transcriptional regulator
RA8CHR_03897	COG0456	acetyltransferase
RA8CHR_03898	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_03902	COG1295	ribonuclease BN
RA8CHR_03905	COG0667	Aldo Keto reductase
RA8CHR_03910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RA8CHR_03911	COG1136	(ABC) transporter
RA8CHR_03914	COG0626	cystathionine gamma-synthase activity
RA8CHR_03917	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RA8CHR_03918	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RA8CHR_03920	COG0330	HflC and HflK could
RA8CHR_03921	COG0330	HflC and HflK could
RA8CHR_03922	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RA8CHR_03923	COG1923	regulation of RNA biosynthetic process
RA8CHR_03924	COG1160	GTP binding
RA8CHR_03925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RA8CHR_03927	COG0124	histidyl-tRNA synthetase
RA8CHR_03928	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RA8CHR_03931	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RA8CHR_03932	COG0105	UTP biosynthetic process
RA8CHR_03933	COG1187	pseudouridine synthase activity
RA8CHR_03934	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RA8CHR_03935	COG0564	pseudouridine synthase activity
RA8CHR_03937	COG1199	ATP-dependent helicase activity
RA8CHR_03941	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RA8CHR_03942	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RA8CHR_03943	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA8CHR_03944	COG0567	Dehydrogenase, E1 component
RA8CHR_03949	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_03955	COG0163	prenyltransferase activity
RA8CHR_03956	COG1024	Enoyl-CoA hydratase
RA8CHR_03956	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA8CHR_03958	COG0477	Major facilitator Superfamily
RA8CHR_03962	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_03963	COG0745	RESPONSE REGULATOR receiver
RA8CHR_03964	COG0784	Response regulator, receiver
RA8CHR_03964	COG5002	protein histidine kinase activity
RA8CHR_03964	COG2205	protein histidine kinase activity
RA8CHR_03965	COG4566	intracellular signal transduction
RA8CHR_03966	COG5002	protein histidine kinase activity
RA8CHR_03966	COG5001	Diguanylate cyclase
RA8CHR_03967	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RA8CHR_03968	COG2963	transposase activity
RA8CHR_03969	COG2801	Transposase and inactivated derivatives
RA8CHR_03976	COG4608	Belongs to the ABC transporter superfamily
RA8CHR_03978	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA8CHR_03979	COG0601	transmembrane transport
RA8CHR_03984	COG4792	protein secretion
RA8CHR_03996	COG4789	Type iii secretion
RA8CHR_03999	COG0604	alcohol dehydrogenase
RA8CHR_04002	COG2814	Major facilitator Superfamily
RA8CHR_04004	COG0604	alcohol dehydrogenase
RA8CHR_04004	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04004	COG3321	synthase
RA8CHR_04007	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_04016	COG0633	Ferredoxin
RA8CHR_04018	COG0683	leucine binding
RA8CHR_04021	COG0411	ABC transporter
RA8CHR_04022	COG0410	ABC transporter
RA8CHR_04025	COG0066	3-isopropylmalate dehydratase activity
RA8CHR_04026	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RA8CHR_04028	COG2188	Transcriptional regulator
RA8CHR_04032	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04036	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RA8CHR_04037	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_04038	COG1802	Transcriptional regulator
RA8CHR_04040	COG1116	anion transmembrane transporter activity
RA8CHR_04041	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_04046	COG1360	Flagellar Motor Protein
RA8CHR_04050	COG0473	3-isopropylmalate dehydrogenase activity
RA8CHR_04051	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RA8CHR_04053	COG2133	pyrroloquinoline quinone binding
RA8CHR_04054	COG0791	NLP P60 protein
RA8CHR_04055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RA8CHR_04056	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA8CHR_04057	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RA8CHR_04058	COG4191	Histidine kinase
RA8CHR_04059	COG4566	intracellular signal transduction
RA8CHR_04060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RA8CHR_04063	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RA8CHR_04064	COG0167	dihydroorotate dehydrogenase activity
RA8CHR_04067	COG0579	oxidoreductase
RA8CHR_04072	COG0443	Heat shock 70 kDa protein
RA8CHR_04075	COG0822	iron-sulfur transferase activity
RA8CHR_04076	COG1104	cysteine desulfurase activity
RA8CHR_04077	COG1959	2 iron, 2 sulfur cluster binding
RA8CHR_04078	COG0556	nucleotide-excision repair
RA8CHR_04081	COG2878	Part of a membrane complex involved in electron transport
RA8CHR_04084	COG4770	biotin carboxylase activity
RA8CHR_04086	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RA8CHR_04087	COG1703	isobutyryl-CoA mutase activity
RA8CHR_04088	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RA8CHR_04088	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RA8CHR_04089	COG1802	Transcriptional regulator
RA8CHR_04093	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RA8CHR_04094	COG1201	RNA secondary structure unwinding
RA8CHR_04095	COG0745	RESPONSE REGULATOR receiver
RA8CHR_04103	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RA8CHR_04103	COG4651	solute:proton antiporter activity
RA8CHR_04104	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04106	COG0183	Belongs to the thiolase family
RA8CHR_04107	COG3243	poly(R)-hydroxyalkanoic acid synthase
RA8CHR_04113	COG3045	CreA protein
RA8CHR_04116	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_04119	COG0583	DNA-binding transcription factor activity
RA8CHR_04120	COG3622	Belongs to the hyi family
RA8CHR_04122	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04128	COG0583	DNA-binding transcription factor activity
RA8CHR_04129	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04138	COG0446	pyridine nucleotide-disulphide oxidoreductase
RA8CHR_04142	COG0583	DNA-binding transcription factor activity
RA8CHR_04146	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RA8CHR_04153	COG2197	response regulator
RA8CHR_04154	COG2197	response regulator
RA8CHR_04158	COG0784	Response regulator, receiver
RA8CHR_04158	COG2205	protein histidine kinase activity
RA8CHR_04160	COG0583	DNA-binding transcription factor activity
RA8CHR_04167	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RA8CHR_04168	COG2207	Transcriptional regulator
RA8CHR_04169	COG2807	transmembrane transport
RA8CHR_04170	COG0625	glutathione transferase activity
RA8CHR_04173	COG1741	Belongs to the pirin family
RA8CHR_04179	COG0625	glutathione transferase activity
RA8CHR_04185	COG2353	YceI-like domain
RA8CHR_04186	COG1764	response to oxidative stress
RA8CHR_04187	COG0753	catalase activity
RA8CHR_04188	COG0583	DNA-binding transcription factor activity
RA8CHR_04189	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04191	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RA8CHR_04191	COG2755	lipolytic protein G-D-S-L family
RA8CHR_04196	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_04198	COG0596	Alpha beta hydrolase
RA8CHR_04207	COG2309	aminopeptidase activity
RA8CHR_04208	COG1335	isochorismatase
RA8CHR_04210	COG0559	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_04214	COG0583	DNA-binding transcription factor activity
RA8CHR_04215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA8CHR_04216	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04217	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04219	COG1024	Enoyl-CoA hydratase
RA8CHR_04220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_04223	COG0183	Belongs to the thiolase family
RA8CHR_04227	COG2207	Transcriptional regulator
RA8CHR_04228	COG1289	transmembrane transporter activity
RA8CHR_04230	COG1566	PFAM secretion protein HlyD family protein
RA8CHR_04237	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_04238	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04239	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_04240	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_04241	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04242	COG2030	dehydratase
RA8CHR_04246	COG0596	Alpha beta hydrolase
RA8CHR_04247	COG2309	aminopeptidase activity
RA8CHR_04248	COG1414	Transcriptional regulator
RA8CHR_04249	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04255	COG1335	isochorismatase
RA8CHR_04261	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_04263	COG0583	DNA-binding transcription factor activity
RA8CHR_04265	COG1024	Enoyl-CoA hydratase
RA8CHR_04270	COG0776	regulation of translation
RA8CHR_04272	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RA8CHR_04273	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RA8CHR_04274	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RA8CHR_04275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RA8CHR_04276	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RA8CHR_04279	COG2224	Isocitrate lyase
RA8CHR_04284	COG1309	transcriptional regulator
RA8CHR_04286	COG0673	inositol 2-dehydrogenase activity
RA8CHR_04297	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RA8CHR_04303	COG0659	secondary active sulfate transmembrane transporter activity
RA8CHR_04307	COG0542	response to heat
RA8CHR_04311	COG0583	DNA-binding transcription factor activity
RA8CHR_04312	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04313	COG0314	molybdopterin synthase activity
RA8CHR_04314	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA8CHR_04315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RA8CHR_04316	COG0303	'Molybdopterin
RA8CHR_04317	COG1763	Mo-molybdopterin cofactor biosynthetic process
RA8CHR_04318	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RA8CHR_04320	COG0436	Aminotransferase
RA8CHR_04322	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RA8CHR_04323	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RA8CHR_04326	COG0305	Participates in initiation and elongation during chromosome replication
RA8CHR_04327	COG0359	binds to the 23S rRNA
RA8CHR_04328	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RA8CHR_04329	COG2965	DNA replication, synthesis of RNA primer
RA8CHR_04330	COG0360	Binds together with S18 to 16S ribosomal RNA
RA8CHR_04333	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RA8CHR_04334	COG3634	alkyl hydroperoxide reductase activity
RA8CHR_04341	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RA8CHR_04342	COG0670	Belongs to the BI1 family
RA8CHR_04343	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RA8CHR_04346	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RA8CHR_04347	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RA8CHR_04351	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RA8CHR_04354	COG0473	3-isopropylmalate dehydrogenase activity
RA8CHR_04355	COG0596	Alpha beta hydrolase
RA8CHR_04356	COG0583	DNA-binding transcription factor activity
RA8CHR_04367	COG0322	excinuclease ABC activity
RA8CHR_04369	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RA8CHR_04370	COG1611	Belongs to the LOG family
RA8CHR_04373	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA8CHR_04375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RA8CHR_04376	COG3237	CsbD-like
RA8CHR_04379	COG0123	including yeast histone deacetylase and acetoin utilization protein
RA8CHR_04382	COG1295	ribonuclease BN
RA8CHR_04382	COG1959	2 iron, 2 sulfur cluster binding
RA8CHR_04385	COG2814	Major facilitator Superfamily
RA8CHR_04388	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_04389	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RA8CHR_04391	COG0583	DNA-binding transcription factor activity
RA8CHR_04392	COG2910	NAD(P)H-binding
RA8CHR_04401	COG1802	Transcriptional regulator
RA8CHR_04403	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RA8CHR_04405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_04409	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_04410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA8CHR_04412	COG2186	Transcriptional regulator
RA8CHR_04413	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA8CHR_04415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA8CHR_04418	COG2721	sulfolactate sulfo-lyase activity
RA8CHR_04419	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04420	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04421	COG0688	phosphatidylethanolamine metabolic process
RA8CHR_04424	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RA8CHR_04425	COG0443	Heat shock 70 kDa protein
RA8CHR_04426	COG0484	heat shock protein binding
RA8CHR_04427	COG2186	Transcriptional regulator
RA8CHR_04428	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_04430	COG2766	serine protein kinase
RA8CHR_04431	COG2718	Belongs to the UPF0229 family
RA8CHR_04432	COG2719	SpoVR family
RA8CHR_04433	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_04439	COG2818	Glycosylase
RA8CHR_04440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RA8CHR_04441	COG1609	Transcriptional regulator
RA8CHR_04443	COG2186	Transcriptional regulator
RA8CHR_04447	COG0625	glutathione transferase activity
RA8CHR_04453	COG4770	biotin carboxylase activity
RA8CHR_04454	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RA8CHR_04455	COG3265	gluconokinase activity
RA8CHR_04458	COG1538	Outer membrane efflux protein
RA8CHR_04462	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RA8CHR_04464	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_04467	COG2267	carboxylic ester hydrolase activity
RA8CHR_04468	COG0702	epimerase
RA8CHR_04469	COG3118	belongs to the thioredoxin family
RA8CHR_04470	COG1295	ribonuclease BN
RA8CHR_04472	COG0277	FAD linked oxidase domain protein
RA8CHR_04473	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RA8CHR_04478	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RA8CHR_04479	COG2963	transposase activity
RA8CHR_04480	COG2801	Transposase and inactivated derivatives
RA8CHR_04485	COG1396	sequence-specific DNA binding
RA8CHR_04485	COG3800	Transcriptional regulator
RA8CHR_04487	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
RA8CHR_04490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RA8CHR_04499	COG0708	Exodeoxyribonuclease III
RA8CHR_04502	COG3852	Histidine kinase
RA8CHR_04504	COG0174	glutamine synthetase
RA8CHR_04505	COG1546	Belongs to the CinA family
RA8CHR_04505	COG1058	Belongs to the CinA family
RA8CHR_04512	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RA8CHR_04512	COG4797	methyltransferase
RA8CHR_04517	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RA8CHR_04521	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RA8CHR_04523	COG0287	Prephenate dehydrogenase
RA8CHR_04524	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RA8CHR_04528	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RA8CHR_04533	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RA8CHR_04534	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RA8CHR_04534	COG2111	Na H antiporter
RA8CHR_04535	COG1006	Multisubunit Na H antiporter MnhC subunit
RA8CHR_04536	COG0651	ATP synthesis coupled electron transport
RA8CHR_04538	COG2212	antiporter activity
RA8CHR_04539	COG1320	monovalent cation:proton antiporter activity
RA8CHR_04549	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RA8CHR_04549	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RA8CHR_04559	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RA8CHR_04559	COG3608	succinylglutamate desuccinylase aspartoacylase
RA8CHR_04562	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RA8CHR_04568	COG1027	Aspartate ammonia-lyase
RA8CHR_04569	COG2311	Membrane
RA8CHR_04572	COG2005	Transcriptional regulator
RA8CHR_04572	COG3585	molybdate ion transport
RA8CHR_04575	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RA8CHR_04577	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RA8CHR_04578	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_04579	COG1522	sequence-specific DNA binding
RA8CHR_04591	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RA8CHR_04592	COG2151	metal-sulfur cluster biosynthetic enzyme
RA8CHR_04593	COG3396	Phenylacetate-CoA oxygenase
RA8CHR_04594	COG3460	Phenylacetate-CoA oxygenase
RA8CHR_04595	COG3396	Phenylacetate-CoA oxygenase
RA8CHR_04597	COG2050	protein possibly involved in aromatic compounds catabolism
RA8CHR_04598	COG1024	Enoyl-CoA hydratase
RA8CHR_04600	COG1309	transcriptional regulator
RA8CHR_04601	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RA8CHR_04605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RA8CHR_04606	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RA8CHR_04608	COG1722	exodeoxyribonuclease VII activity
RA8CHR_04616	COG3360	Dodecin
RA8CHR_04619	COG0412	Dienelactone hydrolase
RA8CHR_04621	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA8CHR_04627	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RA8CHR_04629	COG0210	DNA helicase
RA8CHR_04632	COG0516	GMP reductase activity
RA8CHR_04634	COG0300	oxidoreductase activity
RA8CHR_04635	COG0183	Belongs to the thiolase family
RA8CHR_04638	COG0513	Belongs to the DEAD box helicase family
RA8CHR_04639	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RA8CHR_04640	COG0501	Belongs to the peptidase M48B family
RA8CHR_04641	COG2154	pterin-4-alpha-carbinolamine dehydratase
RA8CHR_04642	COG1162	GTPase activity
RA8CHR_04643	COG0438	transferase activity, transferring glycosyl groups
RA8CHR_04644	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RA8CHR_04645	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RA8CHR_04647	COG0335	large ribosomal subunit rRNA binding
RA8CHR_04648	COG0336	Belongs to the RNA methyltransferase TrmD family
RA8CHR_04649	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RA8CHR_04650	COG0228	four-way junction DNA binding
RA8CHR_04653	COG0306	phosphate transporter
RA8CHR_04654	COG1392	Phosphate transport regulator
RA8CHR_04656	COG0617	tRNA 3'-terminal CCA addition
RA8CHR_04657	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RA8CHR_04658	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RA8CHR_04659	COG0628	permease
RA8CHR_04662	COG0438	transferase activity, transferring glycosyl groups
RA8CHR_04666	COG0728	peptidoglycan biosynthetic process
RA8CHR_04667	COG0268	Binds directly to 16S ribosomal RNA
RA8CHR_04669	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RA8CHR_04670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RA8CHR_04671	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RA8CHR_04673	COG3483	tryptophan 2,3-dioxygenase activity
RA8CHR_04675	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04682	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_04688	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RA8CHR_04694	COG4106	trans-aconitate 2-methyltransferase activity
RA8CHR_04695	COG0039	L-malate dehydrogenase activity
RA8CHR_04696	COG2188	Transcriptional regulator
RA8CHR_04699	COG1053	succinate dehydrogenase
RA8CHR_04700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RA8CHR_04701	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RA8CHR_04702	COG0372	Belongs to the citrate synthase family
RA8CHR_04705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RA8CHR_04706	COG0066	3-isopropylmalate dehydratase activity
RA8CHR_04707	COG0473	3-isopropylmalate dehydrogenase activity
RA8CHR_04708	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RA8CHR_04710	COG0101	tRNA pseudouridine synthase activity
RA8CHR_04711	COG0135	phosphoribosylanthranilate isomerase activity
RA8CHR_04712	COG0133	tryptophan synthase activity
RA8CHR_04713	COG0159	tryptophan synthase activity
RA8CHR_04714	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RA8CHR_04715	COG0762	integral membrane protein
RA8CHR_04717	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RA8CHR_04718	COG0443	Heat shock 70 kDa protein
RA8CHR_04719	COG1451	nucleotide metabolic process
RA8CHR_04720	COG1472	Belongs to the glycosyl hydrolase 3 family
RA8CHR_04721	COG0736	holo-[acyl-carrier-protein] synthase activity
RA8CHR_04722	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RA8CHR_04723	COG1381	Involved in DNA repair and RecF pathway recombination
RA8CHR_04724	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RA8CHR_04725	COG0571	ribonuclease III activity
RA8CHR_04727	COG0681	Belongs to the peptidase S26 family
RA8CHR_04728	COG0481	GTPase activity
RA8CHR_04729	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_04733	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RA8CHR_04734	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RA8CHR_04735	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04736	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RA8CHR_04737	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RA8CHR_04738	COG0416	fatty acid biosynthetic process
RA8CHR_04739	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RA8CHR_04740	COG1399	metal-binding, possibly nucleic acid-binding protein
RA8CHR_04741	COG0424	maF-like protein
RA8CHR_04742	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RA8CHR_04743	COG2223	nitrite transmembrane transporter activity
RA8CHR_04744	COG0616	signal peptide processing
RA8CHR_04744	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RA8CHR_04747	COG0564	pseudouridine synthase activity
RA8CHR_04748	COG1530	ribonuclease E activity
RA8CHR_04751	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA8CHR_04755	COG0297	glycogen (starch) synthase activity
RA8CHR_04756	COG0489	protein tyrosine kinase activity
RA8CHR_04756	COG3206	protein involved in exopolysaccharide biosynthesis
RA8CHR_04757	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RA8CHR_04762	COG0181	hydroxymethylbilane synthase activity
RA8CHR_04763	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RA8CHR_04764	COG0583	DNA-binding transcription factor activity
RA8CHR_04765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RA8CHR_04773	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RA8CHR_04773	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RA8CHR_04776	COG3022	response to hydroperoxide
RA8CHR_04777	COG0525	valine-tRNA ligase activity
RA8CHR_04780	COG0425	Belongs to the sulfur carrier protein TusA family
RA8CHR_04784	COG0724	RNA recognition motif
RA8CHR_04790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_04798	COG0559	Belongs to the binding-protein-dependent transport system permease family
RA8CHR_04799	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RA8CHR_04800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RA8CHR_04801	COG1674	ftsk spoiiie
RA8CHR_04803	COG0492	ferredoxin-NADP+ reductase activity
RA8CHR_04804	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RA8CHR_04805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RA8CHR_04807	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RA8CHR_04807	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RA8CHR_04811	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RA8CHR_04812	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_04813	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_04815	COG1024	Enoyl-CoA hydratase
RA8CHR_04817	COG0196	riboflavin kinase activity
RA8CHR_04819	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RA8CHR_04820	COG1283	sodium-dependent phosphate transmembrane transporter activity
RA8CHR_04823	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_04824	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_04825	COG4608	Belongs to the ABC transporter superfamily
RA8CHR_04826	COG0444	Belongs to the ABC transporter superfamily
RA8CHR_04828	COG0402	S-adenosylhomocysteine deaminase activity
RA8CHR_04829	COG0747	negative chemotaxis
RA8CHR_04832	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04834	COG0405	Gamma-glutamyltransferase
RA8CHR_04838	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RA8CHR_04839	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RA8CHR_04842	COG0084	hydrolase, TatD family'
RA8CHR_04843	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_04844	COG0714	Associated with various cellular activities
RA8CHR_04846	COG2304	oxidoreductase activity
RA8CHR_04847	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_04848	COG0583	DNA-binding transcription factor activity
RA8CHR_04849	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_04850	COG0445	tRNA wobble uridine modification
RA8CHR_04855	COG3550	peptidyl-serine autophosphorylation
RA8CHR_04857	COG1136	(ABC) transporter
RA8CHR_04860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RA8CHR_04866	COG0831	urea catabolic process
RA8CHR_04868	COG0832	Belongs to the urease beta subunit family
RA8CHR_04869	COG0804	urea catabolic process
RA8CHR_04871	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RA8CHR_04872	COG0830	nickel cation binding
RA8CHR_04873	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RA8CHR_04875	COG0028	Belongs to the TPP enzyme family
RA8CHR_04884	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RA8CHR_04885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RA8CHR_04886	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RA8CHR_04888	COG2815	serine threonine protein kinase
RA8CHR_04888	COG0515	serine threonine protein kinase
RA8CHR_04889	COG1561	YicC-like family, N-terminal region
RA8CHR_04890	COG0194	GDP metabolic process
RA8CHR_04891	COG1758	RNA polymerase activity
RA8CHR_04892	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RA8CHR_04930	COG0358	DNA primase activity
RA8CHR_04945	COG0328	RNA-DNA hybrid ribonuclease activity
RA8CHR_04949	COG2084	Dehydrogenase
RA8CHR_04958	COG1126	abc transporter atp-binding protein
RA8CHR_04960	COG0765	amino acid transport
RA8CHR_04961	COG0765	amino acid transport
RA8CHR_05035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RA8CHR_05038	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05046	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RA8CHR_05047	COG1061	Type III restriction enzyme res subunit
RA8CHR_05048	COG1002	Type II restriction enzyme, methylase subunits
RA8CHR_05052	COG1420	regulation of RNA biosynthetic process
RA8CHR_05053	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RA8CHR_05054	COG0497	DNA recombination
RA8CHR_05055	COG1660	Displays ATPase and GTPase activities
RA8CHR_05057	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RA8CHR_05058	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RA8CHR_05061	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RA8CHR_05063	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RA8CHR_05064	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RA8CHR_05065	COG0193	aminoacyl-tRNA hydrolase activity
RA8CHR_05067	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RA8CHR_05069	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA8CHR_05071	COG4608	Belongs to the ABC transporter superfamily
RA8CHR_05072	COG0747	negative chemotaxis
RA8CHR_05073	COG0154	amidase activity
RA8CHR_05074	COG0583	DNA-binding transcription factor activity
RA8CHR_05080	COG0588	phosphoglycerate mutase activity
RA8CHR_05081	COG2267	carboxylic ester hydrolase activity
RA8CHR_05083	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA8CHR_05084	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RA8CHR_05085	COG0596	Alpha beta hydrolase
RA8CHR_05086	COG0280	phosphate acetyltransferase
RA8CHR_05086	COG0281	malic enzyme
RA8CHR_05087	COG1301	dicarboxylic acid transport
RA8CHR_05088	COG1252	NADH dehydrogenase
RA8CHR_05089	COG0183	Belongs to the thiolase family
RA8CHR_05090	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_05093	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RA8CHR_05094	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RA8CHR_05095	COG1984	allophanate hydrolase subunit 2
RA8CHR_05096	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RA8CHR_05097	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RA8CHR_05098	COG0742	ribosomal rna small subunit methyltransferase
RA8CHR_05099	COG0612	Peptidase, M16
RA8CHR_05100	COG0612	Peptidase, M16
RA8CHR_05103	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RA8CHR_05104	COG1999	signal sequence binding
RA8CHR_05105	COG0109	protoheme IX farnesyltransferase activity
RA8CHR_05112	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RA8CHR_05114	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RA8CHR_05115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RA8CHR_05117	COG2226	methyltransferase
RA8CHR_05119	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RA8CHR_05121	COG0489	protein tyrosine kinase activity
RA8CHR_05125	COG1024	Enoyl-CoA hydratase
RA8CHR_05130	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_05135	COG1690	Belongs to the RtcB family
RA8CHR_05136	COG2423	ornithine cyclodeaminase activity
RA8CHR_05137	COG0183	Belongs to the thiolase family
RA8CHR_05138	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RA8CHR_05140	COG1414	Transcriptional regulator
RA8CHR_05144	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_05147	COG2175	clavaminate synthase activity
RA8CHR_05149	COG3246	L-lysine catabolic process to acetate
RA8CHR_05151	COG1414	Transcriptional regulator
RA8CHR_05152	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05153	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_05154	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05155	COG2175	clavaminate synthase activity
RA8CHR_05157	COG0028	Belongs to the TPP enzyme family
RA8CHR_05158	COG3246	L-lysine catabolic process to acetate
RA8CHR_05164	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RA8CHR_05166	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA8CHR_05170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RA8CHR_05174	COG2149	membrane
RA8CHR_05178	COG0724	RNA recognition motif
RA8CHR_05180	COG1446	asparaginase
RA8CHR_05181	COG4172	Belongs to the ABC transporter superfamily
RA8CHR_05182	COG0747	negative chemotaxis
RA8CHR_05184	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA8CHR_05199	COG1137	ATPase activity
RA8CHR_05203	COG1012	belongs to the aldehyde dehydrogenase family
RA8CHR_05205	COG3474	cytochrome
RA8CHR_05211	COG0583	DNA-binding transcription factor activity
RA8CHR_05212	COG3485	protocatechuate 3,4-dioxygenase
RA8CHR_05213	COG3485	protocatechuate 3,4-dioxygenase
RA8CHR_05215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RA8CHR_05223	COG0582	viral genome integration into host DNA
RA8CHR_05241	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RA8CHR_05246	COG0540	Belongs to the ATCase OTCase family
RA8CHR_05247	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RA8CHR_05248	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RA8CHR_05249	COG1678	Uncharacterized ACR, COG1678
RA8CHR_05250	COG0415	Belongs to the DNA photolyase family
RA8CHR_05251	COG0643	Histidine kinase
RA8CHR_05251	COG0784	Response regulator, receiver
RA8CHR_05251	COG2198	Histidine kinase
RA8CHR_05252	COG0840	transmembrane signaling receptor activity
RA8CHR_05257	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RA8CHR_05258	COG0138	bifunctional purine biosynthesis protein purh
RA8CHR_05261	COG1238	metal cluster binding
RA8CHR_05262	COG0012	GTP binding
RA8CHR_05263	COG3217	Mosc domain protein beta barrel domain protein
RA8CHR_05263	COG0633	Ferredoxin
RA8CHR_05264	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_05267	COG1024	Enoyl-CoA hydratase
RA8CHR_05275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RA8CHR_05278	COG2255	four-way junction helicase activity
RA8CHR_05279	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RA8CHR_05280	COG2267	carboxylic ester hydrolase activity
RA8CHR_05281	COG0671	phosphoesterase, PA-phosphatase related
RA8CHR_05281	COG2453	phosphatase
RA8CHR_05284	COG4589	Belongs to the CDS family
RA8CHR_05285	COG0632	four-way junction helicase activity
RA8CHR_05286	COG1702	phosphate starvation-inducible protein PhoH
RA8CHR_05287	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RA8CHR_05288	COG1490	D-aminoacyl-tRNA deacylase activity
RA8CHR_05289	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RA8CHR_05292	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RA8CHR_05293	COG0739	heme binding
RA8CHR_05294	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RA8CHR_05295	COG2814	Major facilitator Superfamily
RA8CHR_05296	COG0316	Belongs to the HesB IscA family
RA8CHR_05297	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RA8CHR_05298	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RA8CHR_05299	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RA8CHR_05300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RA8CHR_05303	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RA8CHR_05304	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RA8CHR_05311	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RA8CHR_05313	COG0477	Major facilitator Superfamily
RA8CHR_05318	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA8CHR_05320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RA8CHR_05321	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RA8CHR_05323	COG0156	8-amino-7-oxononanoate synthase activity
RA8CHR_05326	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RA8CHR_05328	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RA8CHR_05329	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_05330	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_05333	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RA8CHR_05334	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RA8CHR_05338	COG3012	SEC-C Motif Domain Protein
RA8CHR_05343	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_05345	COG0183	Belongs to the thiolase family
RA8CHR_05346	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RA8CHR_05347	COG0288	reversible hydration of carbon dioxide
RA8CHR_05348	COG0789	Transcriptional regulator
RA8CHR_05351	COG0564	pseudouridine synthase activity
RA8CHR_05352	COG2197	response regulator
RA8CHR_05357	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RA8CHR_05358	COG0751	glycine-tRNA ligase activity
RA8CHR_05359	COG0752	glycyl-tRNA synthetase alpha subunit
RA8CHR_05363	COG0431	NADPH-dependent FMN reductase
RA8CHR_05364	COG0798	PFAM Bile acid sodium symporter
RA8CHR_05368	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RA8CHR_05372	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8CHR_05374	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RA8CHR_05380	COG3186	Phenylalanine-4-hydroxylase
RA8CHR_05382	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_05390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_05391	COG0436	Aminotransferase
RA8CHR_05393	COG0697	spore germination
RA8CHR_05394	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA8CHR_05395	COG1280	lysine exporter protein (LysE YggA)
RA8CHR_05396	COG0625	glutathione transferase activity
RA8CHR_05397	COG0384	phenazine biosynthesis protein PhzF
RA8CHR_05401	COG3485	protocatechuate 3,4-dioxygenase
RA8CHR_05402	COG3468	outer membrane autotransporter barrel domain protein
RA8CHR_05404	COG1324	tolerance protein
RA8CHR_05413	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA8CHR_05414	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RA8CHR_05415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RA8CHR_05418	COG0679	Auxin Efflux Carrier
RA8CHR_05419	COG0210	DNA helicase
RA8CHR_05423	COG1053	succinate dehydrogenase
RA8CHR_05433	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_05434	COG2186	Transcriptional regulator
RA8CHR_05435	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_05442	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05444	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_05446	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05449	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_05450	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_05451	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_05453	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05457	COG0667	Aldo Keto reductase
RA8CHR_05472	COG2030	dehydratase
RA8CHR_05473	COG1024	Enoyl-CoA hydratase
RA8CHR_05474	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_05477	COG1024	Enoyl-CoA hydratase
RA8CHR_05492	COG2204	response regulator
RA8CHR_05493	COG5000	phosphorelay sensor kinase activity
RA8CHR_05495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RA8CHR_05495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RA8CHR_05497	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RA8CHR_05498	COG0085	RNA polymerase activity
RA8CHR_05499	COG0222	ribosome binding
RA8CHR_05500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RA8CHR_05501	COG0081	regulation of translation
RA8CHR_05502	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RA8CHR_05504	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RA8CHR_05506	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RA8CHR_05510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RA8CHR_05511	COG0134	indole-3-glycerol-phosphate synthase activity
RA8CHR_05512	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RA8CHR_05513	COG1280	lysine exporter protein (LysE YggA)
RA8CHR_05528	COG4638	Rieske (2fe-2S)
RA8CHR_05531	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_05532	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RA8CHR_05542	COG2313	pseudouridylate synthase activity
RA8CHR_05543	COG0604	alcohol dehydrogenase
RA8CHR_05545	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA8CHR_05547	COG0546	phosphoglycolate phosphatase activity
RA8CHR_05548	COG2197	response regulator
RA8CHR_05550	COG3916	Acyl-homoserine-lactone synthase
RA8CHR_05552	COG0745	RESPONSE REGULATOR receiver
RA8CHR_05566	COG0631	protein serine/threonine phosphatase activity
RA8CHR_05572	COG3501	Rhs element vgr protein
RA8CHR_05573	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RA8CHR_05582	COG0515	serine threonine protein kinase
RA8CHR_05590	COG2831	hemolysin activation secretion protein
RA8CHR_05591	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RA8CHR_05592	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RA8CHR_05595	COG4251	negative regulation of phosphorylation
RA8CHR_05600	COG0018	arginyl-trna synthetase
RA8CHR_05602	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RA8CHR_05603	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RA8CHR_05604	COG1137	ATPase activity
RA8CHR_05605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RA8CHR_05606	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_05615	COG2197	response regulator
RA8CHR_05620	COG3179	chitinase
RA8CHR_05623	COG0653	protein targeting
RA8CHR_05628	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RA8CHR_05635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_05637	COG0583	DNA-binding transcription factor activity
RA8CHR_05639	COG2197	response regulator
RA8CHR_05640	COG2198	Histidine kinase
RA8CHR_05640	COG0784	Response regulator, receiver
RA8CHR_05640	COG2205	protein histidine kinase activity
RA8CHR_05644	COG1396	sequence-specific DNA binding
RA8CHR_05645	COG0235	Class ii aldolase
RA8CHR_05646	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RA8CHR_05649	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RA8CHR_05651	COG2967	ApaG domain
RA8CHR_05652	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RA8CHR_05659	COG2205	protein histidine kinase activity
RA8CHR_05660	COG0745	RESPONSE REGULATOR receiver
RA8CHR_05667	COG2084	Dehydrogenase
RA8CHR_05669	COG4948	Mandelate Racemase Muconate Lactonizing
RA8CHR_05670	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05671	COG1609	Transcriptional regulator
RA8CHR_05672	COG0515	serine threonine protein kinase
RA8CHR_05672	COG2815	serine threonine protein kinase
RA8CHR_05682	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_05683	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RA8CHR_05684	COG1414	Transcriptional regulator
RA8CHR_05685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RA8CHR_05686	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RA8CHR_05691	COG0583	DNA-binding transcription factor activity
RA8CHR_05693	COG0183	Belongs to the thiolase family
RA8CHR_05694	COG1024	Enoyl-CoA hydratase
RA8CHR_05695	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_05696	COG0583	DNA-binding transcription factor activity
RA8CHR_05699	COG0205	6-phosphofructokinase activity
RA8CHR_05701	COG2814	Major facilitator Superfamily
RA8CHR_05702	COG0121	glutamine amidotransferase
RA8CHR_05704	COG0189	ligase activity
RA8CHR_05705	COG3135	benzoate transporter
RA8CHR_05706	COG3158	transport of potassium into the cell
RA8CHR_05708	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RA8CHR_05709	COG1466	dna polymerase III delta subunit
RA8CHR_05711	COG0495	leucyl-tRNA aminoacylation
RA8CHR_05714	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RA8CHR_05715	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RA8CHR_05716	COG0735	belongs to the Fur family
RA8CHR_05717	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RA8CHR_05719	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RA8CHR_05720	COG0210	DNA helicase
RA8CHR_05721	COG0598	Magnesium transport protein CorA
RA8CHR_05723	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_05727	COG0745	RESPONSE REGULATOR receiver
RA8CHR_05730	COG0482	sulfurtransferase activity
RA8CHR_05732	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA8CHR_05736	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RA8CHR_05738	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RA8CHR_05740	COG0438	transferase activity, transferring glycosyl groups
RA8CHR_05742	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RA8CHR_05743	COG1596	polysaccharide export
RA8CHR_05744	COG0629	single-stranded DNA binding
RA8CHR_05749	COG1946	Acyl-CoA thioesterase
RA8CHR_05750	COG0446	pyridine nucleotide-disulphide oxidoreductase
RA8CHR_05751	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05753	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_05756	COG0583	DNA-binding transcription factor activity
RA8CHR_05758	COG3437	response regulator, receiver
RA8CHR_05758	COG3850	Histidine kinase
RA8CHR_05758	COG2205	protein histidine kinase activity
RA8CHR_05758	COG2205	protein histidine kinase activity
RA8CHR_05758	COG3437	response regulator, receiver
RA8CHR_05758	COG3850	Histidine kinase
RA8CHR_05758	COG4999	Histidine kinase
RA8CHR_05758	COG4999	Histidine kinase
RA8CHR_05760	COG0745	RESPONSE REGULATOR receiver
RA8CHR_05761	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_05762	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RA8CHR_05764	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_05774	COG0284	orotidine-5'-phosphate decarboxylase activity
RA8CHR_05780	COG0009	L-threonylcarbamoyladenylate synthase
RA8CHR_05781	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RA8CHR_05782	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RA8CHR_05783	COG3118	belongs to the thioredoxin family
RA8CHR_05787	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RA8CHR_05789	COG0469	pyruvate kinase activity
RA8CHR_05790	COG0126	phosphoglycerate kinase activity
RA8CHR_05791	COG0583	DNA-binding transcription factor activity
RA8CHR_05794	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_05798	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RA8CHR_05800	COG0242	peptide deformylase activity
RA8CHR_05802	COG0758	DNA mediated transformation
RA8CHR_05803	COG2922	Belongs to the Smg family
RA8CHR_05806	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RA8CHR_05807	COG1862	Preprotein translocase
RA8CHR_05810	COG1522	sequence-specific DNA binding
RA8CHR_05811	COG2814	Major facilitator Superfamily
RA8CHR_05812	COG1959	2 iron, 2 sulfur cluster binding
RA8CHR_05813	COG0644	oxidoreductase
RA8CHR_05819	COG0251	oxidation-reduction process
RA8CHR_05820	COG3622	Belongs to the hyi family
RA8CHR_05821	COG0235	Class ii aldolase
RA8CHR_05822	COG3395	kinase activity
RA8CHR_05823	COG2084	Dehydrogenase
RA8CHR_05827	COG0583	DNA-binding transcription factor activity
RA8CHR_05828	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RA8CHR_05830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RA8CHR_05831	COG0045	succinate-CoA ligase (ADP-forming) activity
RA8CHR_05833	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_05834	COG4191	Histidine kinase
RA8CHR_05845	COG0513	Belongs to the DEAD box helicase family
RA8CHR_05846	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RA8CHR_05847	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA8CHR_05849	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RA8CHR_05851	COG0551	DNA topoisomerase type I activity
RA8CHR_05851	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RA8CHR_05853	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RA8CHR_05853	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RA8CHR_05855	COG0642	Histidine kinase
RA8CHR_05858	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RA8CHR_05859	COG2137	regulation of response to DNA damage stimulus
RA8CHR_05860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RA8CHR_05861	COG0045	succinate-CoA ligase (ADP-forming) activity
RA8CHR_05862	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RA8CHR_05863	COG0861	Integral membrane protein TerC family
RA8CHR_05864	COG0631	protein serine/threonine phosphatase activity
RA8CHR_05868	COG4969	Belongs to the N-Me-Phe pilin family
RA8CHR_05870	COG3307	-O-antigen
RA8CHR_05877	COG0438	transferase activity, transferring glycosyl groups
RA8CHR_05878	COG1215	transferase activity, transferring glycosyl groups
RA8CHR_05880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RA8CHR_05881	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RA8CHR_05889	COG0315	cyclic pyranopterin monophosphate synthase activity
RA8CHR_05890	COG4783	chaperone-mediated protein folding
RA8CHR_05891	COG1950	PFAM Membrane protein of
RA8CHR_05893	COG0861	Integral membrane protein TerC family
RA8CHR_05900	COG4269	membrane
RA8CHR_05901	COG0625	glutathione transferase activity
RA8CHR_05904	COG1595	DNA-templated transcription, initiation
RA8CHR_05906	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RA8CHR_05910	COG4566	intracellular signal transduction
RA8CHR_05917	COG2076	Multidrug Resistance protein
RA8CHR_05918	COG0546	phosphoglycolate phosphatase activity
RA8CHR_05918	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RA8CHR_05921	COG1522	sequence-specific DNA binding
RA8CHR_05922	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RA8CHR_05923	COG1309	transcriptional regulator
RA8CHR_05933	COG1058	Belongs to the CinA family
RA8CHR_05933	COG1546	Belongs to the CinA family
RA8CHR_05935	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_05936	COG1295	ribonuclease BN
RA8CHR_05937	COG0583	DNA-binding transcription factor activity
RA8CHR_05938	COG4221	oxidoreductase activity
RA8CHR_05939	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_05940	COG1047	Peptidyl-prolyl cis-trans
RA8CHR_05947	COG0473	3-isopropylmalate dehydrogenase activity
RA8CHR_05948	COG0066	3-isopropylmalate dehydratase activity
RA8CHR_05949	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RA8CHR_05951	COG0583	DNA-binding transcription factor activity
RA8CHR_05952	COG0583	DNA-binding transcription factor activity
RA8CHR_05954	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_05955	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_05957	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA8CHR_05959	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_05960	COG0784	Response regulator, receiver
RA8CHR_05960	COG2198	Histidine kinase
RA8CHR_05960	COG2205	protein histidine kinase activity
RA8CHR_05961	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RA8CHR_05964	COG0667	Aldo Keto reductase
RA8CHR_05966	COG3639	organic phosphonate transmembrane transporter activity
RA8CHR_05967	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RA8CHR_05968	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RA8CHR_05969	COG1793	dna ligase
RA8CHR_05971	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8CHR_05975	COG1477	protein flavinylation
RA8CHR_05978	COG3454	Phosphonate metabolism
RA8CHR_05979	COG4778	phosphonate C-P lyase system protein PhnL
RA8CHR_05980	COG4107	phosphonate C-P lyase system protein PhnK
RA8CHR_05981	COG3627	carbon phosphorus lyase activity
RA8CHR_05982	COG3626	phosphonate metabolism
RA8CHR_05984	COG3624	Phosphonate C-P lyase system protein PhnG
RA8CHR_05985	COG2188	Transcriptional regulator
RA8CHR_05986	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RA8CHR_05988	COG0583	DNA-binding transcription factor activity
RA8CHR_05989	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA8CHR_05989	COG4221	oxidoreductase activity
RA8CHR_05989	COG0604	alcohol dehydrogenase
RA8CHR_05989	COG3321	synthase
RA8CHR_05991	COG2202	Pas domain
RA8CHR_05991	COG2205	protein histidine kinase activity
RA8CHR_05993	COG0784	Response regulator, receiver
RA8CHR_06000	COG1295	ribonuclease BN
RA8CHR_06003	COG0384	phenazine biosynthesis protein PhzF
RA8CHR_06006	COG0445	tRNA wobble uridine modification
RA8CHR_06014	COG0523	cobalamin synthesis protein
RA8CHR_06018	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA8CHR_06019	COG0583	DNA-binding transcription factor activity
RA8CHR_06022	COG0477	Major facilitator Superfamily
RA8CHR_06023	COG0583	DNA-binding transcription factor activity
RA8CHR_06028	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RA8CHR_06033	COG0683	leucine binding
RA8CHR_06034	COG1309	transcriptional regulator
RA8CHR_06038	COG0604	alcohol dehydrogenase
RA8CHR_06040	COG0583	DNA-binding transcription factor activity
RA8CHR_06045	COG4977	sequence-specific DNA binding
RA8CHR_06051	COG0583	DNA-binding transcription factor activity
RA8CHR_06052	COG3485	protocatechuate 3,4-dioxygenase
RA8CHR_06054	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_06060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RA8CHR_06062	COG3546	catalase activity
RA8CHR_06070	COG0514	ATP-dependent DNA helicase (RecQ)
RA8CHR_06074	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RA8CHR_06075	COG5002	protein histidine kinase activity
RA8CHR_06078	COG0730	response to heat
RA8CHR_06079	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_06080	COG0583	DNA-binding transcription factor activity
RA8CHR_06082	COG0604	alcohol dehydrogenase
RA8CHR_06083	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8CHR_06085	COG1414	Transcriptional regulator
RA8CHR_06086	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_06088	COG1028	Short-chain dehydrogenase reductase Sdr
RA8CHR_06090	COG3181	Tripartite tricarboxylate transporter family receptor
RA8CHR_06096	COG0446	pyridine nucleotide-disulphide oxidoreductase
RA8CHR_06108	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RA8CHR_06110	COG4948	Mandelate Racemase Muconate Lactonizing
RA8CHR_06112	COG3710	Transcriptional regulator
RA8CHR_06112	COG0457	Tetratricopeptide repeat
RA8CHR_06123	COG1960	acyl-CoA dehydrogenase activity
RA8CHR_06124	COG0318	PFAM AMP-dependent synthetase and ligase
RA8CHR_06125	COG0583	DNA-binding transcription factor activity
RA8CHR_06132	COG0277	FAD linked oxidase domain protein
RA8CHR_06132	COG0247	lactate metabolic process
RA8CHR_06134	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RA8CHR_06138	COG2094	Belongs to the DNA glycosylase MPG family
RA8CHR_06145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RA8CHR_06149	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RA8CHR_06150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RA8CHR_06151	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RA8CHR_06156	COG0006	proline dipeptidase activity
RA8CHR_06160	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RA8CHR_06164	COG0280	phosphate acetyltransferase
RA8CHR_06164	COG0281	malic enzyme
RA8CHR_06168	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RA8CHR_06169	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RA8CHR_06170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RA8CHR_06172	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RA8CHR_06175	COG2814	Major facilitator Superfamily
RA8CHR_06176	COG2267	carboxylic ester hydrolase activity
RA8CHR_06180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA8CHR_06181	COG1739	Uncharacterized protein family UPF0029
RA8CHR_06182	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RA8CHR_06182	COG2813	Specifically methylates the guanine in position
RA8CHR_06183	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RA8CHR_06184	COG2119	membrane
RA8CHR_06185	COG0724	RNA recognition motif
RA8CHR_06186	COG0300	oxidoreductase activity
RA8CHR_06188	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RA8CHR_06193	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RA8CHR_06194	COG0706	membrane insertase activity
RA8CHR_06195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RA8CHR_06196	COG0594	ribonuclease P activity
RA8CHR_06197	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RA8P1_00001	COG1192	Involved in chromosome partitioning
RA8P1_00008	COG1605	Chorismate mutase
RA8P1_00013	COG2801	Transposase and inactivated derivatives
RA8P1_00014	COG2963	transposase activity
RA8P1_00019	COG0196	riboflavin kinase activity
RA8P1_00024	COG0778	Nitroreductase
RA8P1_00026	COG3485	protocatechuate 3,4-dioxygenase
RA8P1_00030	COG1595	DNA-templated transcription, initiation
RA8P1_00031	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RA8P1_00032	COG4372	Transposase
RA8P1_00034	COG1074	ATP-dependent DNA helicase activity
RA8P1_00036	COG3039	Transposase
RA8P1_00039	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8P1_00041	COG0583	DNA-binding transcription factor activity
RA8P1_00052	COG1028	Short-chain dehydrogenase reductase Sdr
RA8P1_00053	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RA8P1_00054	COG2084	Dehydrogenase
RA8P1_00056	COG1414	Transcriptional regulator
RA8P1_00061	COG3621	Patatin-like phospholipase
RA8P1_00062	COG3621	Patatin-like phospholipase
RA8P1_00064	COG2124	cytochrome p450
RA8P1_00073	COG1073	alpha beta
RA8P1_00075	COG1028	Short-chain dehydrogenase reductase Sdr
RA8P1_00075	COG3321	synthase
RA8P1_00075	COG0604	alcohol dehydrogenase
RA8P1_00076	COG0596	Alpha beta hydrolase
RA8P1_00086	COG1414	Transcriptional regulator
RA8P1_00088	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA8P1_00103	COG1024	Enoyl-CoA hydratase
RA8P1_00106	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RA8P1_00113	COG0277	FAD linked oxidase domain protein
RA8P1_00114	COG1522	sequence-specific DNA binding
RA8P1_00120	COG1570	exodeoxyribonuclease VII activity
RA8P1_00125	COG3181	Tripartite tricarboxylate transporter family receptor
RA8P1_00127	COG0583	DNA-binding transcription factor activity
RA8P1_00128	COG1609	Transcriptional regulator
RA8P1_00131	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RA8P1_00132	COG1024	Enoyl-CoA hydratase
RA8P1_00133	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RA8P1_00134	COG3181	Tripartite tricarboxylate transporter family receptor
RA8P1_00137	COG3181	Tripartite tricarboxylate transporter family receptor
RA8P1_00138	COG3181	Tripartite tricarboxylate transporter family receptor
RA8P1_00139	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA8P1_00169	COG4638	Rieske (2fe-2S)
RA8P1_00182	COG0210	DNA helicase
RA8P1_00188	COG1570	exodeoxyribonuclease VII activity
RA8P1_00202	COG3177	Filamentation induced by cAMP protein fic
RA8P1_00203	COG0587	DNA-directed DNA polymerase activity
RA8P1_00217	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA8P1_00218	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RA8P1_00223	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RA8P1_00226	COG0789	Transcriptional regulator
RA8P1_00227	COG0672	)-iron permease
RA8P1_00231	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RA8P1_00232	COG0583	DNA-binding transcription factor activity
RA8P1_00234	COG1959	2 iron, 2 sulfur cluster binding
RA8P1_00236	COG1074	ATP-dependent DNA helicase activity
RA8P1_00237	COG3593	DNA synthesis involved in DNA repair
RA8P1_00246	COG3077	Addiction module antitoxin, RelB DinJ family
RA8P1_00249	COG4372	Transposase
RA8P1_00251	COG2337	Toxic component of a toxin-antitoxin (TA) module
RA8P1_00252	COG2336	PFAM SpoVT AbrB
RA8P1_00253	COG3622	Belongs to the hyi family
RA8P1_00255	COG0583	DNA-binding transcription factor activity
RA8P1_00256	COG0028	Belongs to the TPP enzyme family
RA8P1_00257	COG3181	Tripartite tricarboxylate transporter family receptor
RA8P1_00259	COG3622	Belongs to the hyi family
RA8P1_00261	COG0604	alcohol dehydrogenase
RA8P1_00261	COG1028	Short-chain dehydrogenase reductase Sdr
RA8P1_00261	COG3321	synthase
RA8P1_00262	COG1028	Short-chain dehydrogenase reductase Sdr
RA8P1_00263	COG3181	Tripartite tricarboxylate transporter family receptor
RA8P1_00264	COG0765	amino acid transport
RA8P1_00265	COG0765	amino acid transport
RA8P1_00272	COG1053	succinate dehydrogenase
RA8P1_00272	COG3976	FMN-binding domain protein
RA8P1_00272	COG0431	NADPH-dependent FMN reductase
RA8P1_00274	COG0154	amidase activity
RA8P1_00276	COG3181	Tripartite tricarboxylate transporter family receptor
RA8P1_00277	COG0436	Aminotransferase
RA8P1_00278	COG0583	DNA-binding transcription factor activity
RA8P1_00282	COG0154	amidase activity
RA8P1_00288	COG2814	Major facilitator Superfamily
RA8P1_00292	COG0418	dihydroorotase activity
RA8P1_00294	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RA8P1_00298	COG0243	molybdopterin cofactor binding
RA8P1_00299	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RA8P1_00307	COG0671	phosphoesterase, PA-phosphatase related
RA8P1_00308	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RA8P1_00309	COG2076	Multidrug Resistance protein
RA8P1_00315	COG0726	polysaccharide deacetylase
RA8P1_00319	COG0745	RESPONSE REGULATOR receiver
RA8P1_00331	COG0402	S-adenosylhomocysteine deaminase activity
RA8P1_00334	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA8P1_00337	COG1475	DNA binding
RA8P1_00342	COG3451	type IV secretory pathway VirB4
RA8P1_00346	COG2963	transposase activity
RA8P1_00347	COG2801	Transposase and inactivated derivatives
RA8P1_00351	COG3504	Conjugal transfer protein
RA8P1_00352	COG2948	multi-organism process
RA8P1_00354	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RA8P1_00361	COG4227	nucleotidyltransferase activity
RA8P1_00364	COG0793	Belongs to the peptidase S41A family
RA8P1_00364	COG3409	Peptidoglycan-binding domain 1 protein
RA8P1_00366	COG0402	S-adenosylhomocysteine deaminase activity
RA8P1_00367	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RA8P1_00369	COG0445	tRNA wobble uridine modification
RA8P1_00376	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RA8P1_00376	COG0512	Glutamine amidotransferase of anthranilate synthase
RA8P1_00381	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA8P1_00381	COG1116	anion transmembrane transporter activity
RA8P1_00382	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8P1_00383	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA8P1_00384	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RA8P1_00387	COG2207	Transcriptional regulator
RA8P1_00388	COG2207	Transcriptional regulator
RA8P1_00389	COG1028	Short-chain dehydrogenase reductase Sdr
RA8P1_00392	COG3177	Filamentation induced by cAMP protein fic
RA8P1_00394	COG2188	Transcriptional regulator
RA8P1_00397	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RA8P1_00397	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RA8P1_00398	COG0066	3-isopropylmalate dehydratase activity
RA8P1_00399	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RA8P1_00402	COG1028	Short-chain dehydrogenase reductase Sdr
RA8P1_00403	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA8P1_00406	COG2963	transposase activity
RA8P1_00418	COG1522	sequence-specific DNA binding
RA8P1_00422	COG1126	abc transporter atp-binding protein
RA8P1_00429	COG3916	Acyl-homoserine-lactone synthase
RA8P1_00430	COG2197	response regulator
RA8P2_00001	COG1192	Involved in chromosome partitioning
RA8P2_00010	COG2805	Type II/IV secretion system protein
RA8P2_00013	COG2198	Histidine kinase
RA8P2_00013	COG0784	Response regulator, receiver
RA8P2_00013	COG5002	protein histidine kinase activity
RA8P2_00032	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RA8P2_00106	COG0116	Belongs to the methyltransferase superfamily
RA8P2_00110	COG1570	exodeoxyribonuclease VII activity
RA8P2_00111	COG1570	exodeoxyribonuclease VII activity
RA8P2_00143	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA8P2_00144	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RA8P2_00158	COG2217	Heavy metal translocating P-type atpase
RA8P2_00165	COG0583	DNA-binding transcription factor activity
RA8P2_00167	COG0626	cystathionine gamma-synthase activity
RA8P2_00168	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA8P2_00169	COG0765	amino acid transport
RA8P2_00170	COG0765	amino acid transport
RA8P2_00171	COG1126	abc transporter atp-binding protein
RA8P2_00176	COG3387	PFAM Glycoside hydrolase 15-related
RA8P2_00182	COG1012	belongs to the aldehyde dehydrogenase family
RA8P2_00188	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RA8P2_00193	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA8P2_00197	COG4716	Myosin-crossreactive antigen
RA8P2_00199	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RA8P2_00200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RA8P2_00201	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RA8P2_00220	COG4372	Transposase
RA8P2_00224	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA8P2_00225	COG0300	oxidoreductase activity
RA8P2_00225	COG0318	PFAM AMP-dependent synthetase and ligase
RA8P2_00225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA8P2_00225	COG1028	Short-chain dehydrogenase reductase Sdr
RA8P2_00225	COG3321	synthase
RA8P2_00234	COG0697	spore germination
RA8P2_00236	COG0464	growth
RA8P2_00253	COG1845	cytochrome c oxidase, subunit III
RA8P2_00254	COG1999	signal sequence binding
RA8P2_00256	COG1845	cytochrome c oxidase, subunit III
RA8P2_00288	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RA8P2_00288	COG4651	solute:proton antiporter activity
RA8P2_00289	COG4651	solute:proton antiporter activity
RA8P2_00289	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RA8P2_00292	COG3189	MarR family transcriptional regulator
RA8P2_00295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RA8P2_00296	COG4191	Histidine kinase
RA8P2_00297	COG2204	response regulator
RA8P2_00299	COG3383	formate dehydrogenase (NAD+) activity
RA8P2_00299	COG0243	molybdopterin cofactor binding
RA8P2_00300	COG0437	4 iron, 4 sulfur cluster binding
RA8P2_00308	COG1595	DNA-templated transcription, initiation
RA8P2_00310	COG3474	cytochrome
RA8P2_00311	COG1573	uracil-dna glycosylase
RA8P2_00312	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RA8P2_00317	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RA8P2_00321	COG3041	Addiction module toxin RelE StbE family
RA8P2_00322	COG3077	Addiction module antitoxin, RelB DinJ family
RA8P2_00329	COG0187	DNA topoisomerase II activity
RA8P2_00335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RA8P2_00340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RA8P2_00365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RA8P2_00414	COG0305	Participates in initiation and elongation during chromosome replication
RA8P2_00419	COG2827	Endonuclease containing a URI domain
RA8P2_00428	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RA8P2_00431	COG2974	May be involved in recombination
RA8P2_00440	COG0557	exoribonuclease II activity
RA8P3_00016	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RA8P3_00020	COG1121	(ABC) transporter
RA8P3_00035	COG3701	Conjugal transfer protein
RA8P3_00036	COG3451	type IV secretory pathway VirB4
RA8P3_00037	COG5268	conjugation
RA8P3_00038	COG3838	Conjugal transfer protein Trbc
RA8P3_00039	COG4962	Type ii secretion system protein e
RA8P3_00045	COG0517	IMP dehydrogenase activity
RA8P3_00048	COG0517	IMP dehydrogenase activity