locus-tag	class	description
SRS16CHR_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SRS16CHR_00002	COG0592	DNA-directed DNA polymerase activity
SRS16CHR_00006	COG1408	metallophosphoesterase
SRS16CHR_00009	COG0392	lysyltransferase activity
SRS16CHR_00010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_00011	COG3568	Endonuclease Exonuclease Phosphatase
SRS16CHR_00014	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SRS16CHR_00019	COG2205	protein histidine kinase activity
SRS16CHR_00020	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_00022	COG2608	mercury ion transmembrane transporter activity
SRS16CHR_00025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SRS16CHR_00029	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_00030	COG0642	Histidine kinase
SRS16CHR_00031	COG1902	pentaerythritol trinitrate reductase activity
SRS16CHR_00034	COG5487	UPF0391 membrane protein
SRS16CHR_00035	COG0445	tRNA wobble uridine modification
SRS16CHR_00036	COG0357	Ribosomal RNA small subunit methyltransferase G
SRS16CHR_00037	COG1280	lysine exporter protein (LysE YggA)
SRS16CHR_00038	COG1192	Involved in chromosome partitioning
SRS16CHR_00042	COG0277	FAD linked oxidase domain protein
SRS16CHR_00043	COG2096	Adenosyltransferase
SRS16CHR_00048	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SRS16CHR_00050	COG0850	regulation of cytokinetic process
SRS16CHR_00052	COG2233	PERMEase
SRS16CHR_00053	COG2050	protein possibly involved in aromatic compounds catabolism
SRS16CHR_00058	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_00065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SRS16CHR_00070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SRS16CHR_00071	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SRS16CHR_00073	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SRS16CHR_00074	COG0583	DNA-binding transcription factor activity
SRS16CHR_00082	COG0235	Class ii aldolase
SRS16CHR_00084	COG1024	Enoyl-CoA hydratase
SRS16CHR_00090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SRS16CHR_00096	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SRS16CHR_00104	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_00108	COG0740	serine-type endopeptidase activity
SRS16CHR_00110	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00115	COG0477	Major facilitator Superfamily
SRS16CHR_00116	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SRS16CHR_00117	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SRS16CHR_00118	COG1845	cytochrome c oxidase, subunit III
SRS16CHR_00119	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SRS16CHR_00122	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SRS16CHR_00125	COG0004	ammonium transporteR
SRS16CHR_00127	COG2207	Transcriptional regulator
SRS16CHR_00128	COG2223	nitrite transmembrane transporter activity
SRS16CHR_00130	COG2205	protein histidine kinase activity
SRS16CHR_00131	COG4789	Type iii secretion
SRS16CHR_00137	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SRS16CHR_00138	COG0450	alkyl hydroperoxide reductase
SRS16CHR_00139	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRS16CHR_00144	COG0640	Transcriptional regulator
SRS16CHR_00146	COG1881	PFAM PEBP family protein
SRS16CHR_00148	COG0583	DNA-binding transcription factor activity
SRS16CHR_00149	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_00150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_00158	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SRS16CHR_00159	COG0700	Nucleoside recognition
SRS16CHR_00165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SRS16CHR_00167	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SRS16CHR_00168	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SRS16CHR_00170	COG2003	Belongs to the UPF0758 family
SRS16CHR_00176	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SRS16CHR_00181	COG1228	amidohydrolase
SRS16CHR_00190	COG0725	ABC transporter, periplasmic molybdate-binding protein
SRS16CHR_00191	COG4149	molybdate abc transporter
SRS16CHR_00195	COG1309	transcriptional regulator
SRS16CHR_00197	COG0583	DNA-binding transcription factor activity
SRS16CHR_00201	COG0646	methionine synthase
SRS16CHR_00201	COG1410	methionine synthase
SRS16CHR_00206	COG1309	transcriptional regulator
SRS16CHR_00216	COG1335	isochorismatase
SRS16CHR_00217	COG2080	2 iron, 2 sulfur cluster binding
SRS16CHR_00218	COG2010	Cytochrome c
SRS16CHR_00218	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SRS16CHR_00220	COG2721	sulfolactate sulfo-lyase activity
SRS16CHR_00224	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16CHR_00225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SRS16CHR_00227	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_00229	COG1126	abc transporter atp-binding protein
SRS16CHR_00230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRS16CHR_00232	COG0765	amino acid transport
SRS16CHR_00234	COG0606	chelatase, subunit chli
SRS16CHR_00236	COG0347	Belongs to the P(II) protein family
SRS16CHR_00237	COG0004	ammonium transporteR
SRS16CHR_00240	COG0247	lactate metabolic process
SRS16CHR_00242	COG0386	Belongs to the glutathione peroxidase family
SRS16CHR_00244	COG0477	Major facilitator Superfamily
SRS16CHR_00245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SRS16CHR_00246	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SRS16CHR_00248	COG0129	dihydroxy-acid dehydratase activity
SRS16CHR_00250	COG3971	2-oxopent-4-enoate hydratase activity
SRS16CHR_00255	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_00258	COG1846	Transcriptional regulator
SRS16CHR_00264	COG2974	May be involved in recombination
SRS16CHR_00270	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_00271	COG0579	oxidoreductase
SRS16CHR_00283	COG1335	isochorismatase
SRS16CHR_00291	COG0583	DNA-binding transcription factor activity
SRS16CHR_00294	COG2072	flavoprotein involved in K transport
SRS16CHR_00295	COG0708	Exodeoxyribonuclease III
SRS16CHR_00296	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SRS16CHR_00298	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SRS16CHR_00299	COG0154	amidase activity
SRS16CHR_00300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SRS16CHR_00301	COG1077	Cell shape determining protein MreB Mrl
SRS16CHR_00304	COG0768	penicillin binding
SRS16CHR_00306	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SRS16CHR_00310	COG0622	Phosphoesterase
SRS16CHR_00311	COG2095	MarC family integral membrane protein
SRS16CHR_00312	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00314	COG0412	Dienelactone hydrolase
SRS16CHR_00315	COG0583	DNA-binding transcription factor activity
SRS16CHR_00318	COG0598	Magnesium transport protein CorA
SRS16CHR_00322	COG3411	Ferredoxin
SRS16CHR_00323	COG2945	thiolester hydrolase activity
SRS16CHR_00324	COG1686	Belongs to the peptidase S11 family
SRS16CHR_00325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SRS16CHR_00326	COG0049	tRNA binding
SRS16CHR_00327	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SRS16CHR_00328	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SRS16CHR_00329	COG0051	transcription antitermination factor activity, RNA binding
SRS16CHR_00330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SRS16CHR_00331	COG0088	Forms part of the polypeptide exit tunnel
SRS16CHR_00332	COG0089	rRNA binding
SRS16CHR_00333	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SRS16CHR_00334	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SRS16CHR_00335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SRS16CHR_00336	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SRS16CHR_00337	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SRS16CHR_00338	COG0255	Belongs to the universal ribosomal protein uL29 family
SRS16CHR_00339	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SRS16CHR_00340	COG0678	peroxiredoxin activity
SRS16CHR_00344	COG3909	cytochrome
SRS16CHR_00345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SRS16CHR_00348	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SRS16CHR_00349	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SRS16CHR_00350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SRS16CHR_00351	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRS16CHR_00352	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SRS16CHR_00353	COG0596	Alpha beta hydrolase
SRS16CHR_00354	COG0281	malic enzyme
SRS16CHR_00354	COG0280	phosphate acetyltransferase
SRS16CHR_00355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SRS16CHR_00356	COG1301	dicarboxylic acid transport
SRS16CHR_00357	COG1252	NADH dehydrogenase
SRS16CHR_00358	COG3243	poly(R)-hydroxyalkanoic acid synthase
SRS16CHR_00359	COG0183	Belongs to the thiolase family
SRS16CHR_00360	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00361	COG1271	oxidase subunit
SRS16CHR_00362	COG1294	oxidase, subunit
SRS16CHR_00367	COG2205	protein histidine kinase activity
SRS16CHR_00368	COG2130	NADP-dependent
SRS16CHR_00370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SRS16CHR_00371	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_00373	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SRS16CHR_00374	COG0321	lipoyl(octanoyl) transferase activity
SRS16CHR_00375	COG2921	Belongs to the UPF0250 family
SRS16CHR_00376	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SRS16CHR_00378	COG0356	it plays a direct role in the translocation of protons across the membrane
SRS16CHR_00380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SRS16CHR_00381	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SRS16CHR_00382	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SRS16CHR_00383	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SRS16CHR_00384	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SRS16CHR_00385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SRS16CHR_00391	COG1129	ABC transporter
SRS16CHR_00392	COG1172	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_00393	COG1879	ABC-type sugar transport system periplasmic component
SRS16CHR_00394	COG0673	inositol 2-dehydrogenase activity
SRS16CHR_00395	COG0517	IMP dehydrogenase activity
SRS16CHR_00395	COG0516	GMP reductase activity
SRS16CHR_00397	COG1881	PFAM PEBP family protein
SRS16CHR_00398	COG3588	fructose-bisphosphate aldolase
SRS16CHR_00399	COG2902	Dehydrogenase
SRS16CHR_00411	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_00412	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_00415	COG0583	DNA-binding transcription factor activity
SRS16CHR_00416	COG4221	oxidoreductase activity
SRS16CHR_00417	COG0583	DNA-binding transcription factor activity
SRS16CHR_00421	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SRS16CHR_00422	COG1073	alpha beta
SRS16CHR_00422	COG2226	methyltransferase
SRS16CHR_00423	COG0583	DNA-binding transcription factor activity
SRS16CHR_00424	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00429	COG0473	3-isopropylmalate dehydrogenase activity
SRS16CHR_00431	COG0473	3-isopropylmalate dehydrogenase activity
SRS16CHR_00432	COG0667	Aldo Keto reductase
SRS16CHR_00438	COG2186	Transcriptional regulator
SRS16CHR_00440	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_00441	COG2084	Dehydrogenase
SRS16CHR_00442	COG0667	Aldo Keto reductase
SRS16CHR_00444	COG0667	Aldo Keto reductase
SRS16CHR_00447	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SRS16CHR_00454	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_00462	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00463	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00465	COG3842	ATPase activity
SRS16CHR_00466	COG0395	ABC-type sugar transport system, permease component
SRS16CHR_00469	COG1233	COG1233 Phytoene dehydrogenase and related
SRS16CHR_00470	COG1609	Transcriptional regulator
SRS16CHR_00475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SRS16CHR_00476	COG0792	nuclease activity
SRS16CHR_00477	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SRS16CHR_00478	COG2823	Periplasmic or secreted lipoprotein
SRS16CHR_00479	COG2084	Dehydrogenase
SRS16CHR_00483	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SRS16CHR_00491	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SRS16CHR_00491	COG2124	cytochrome p450
SRS16CHR_00492	COG1309	transcriptional regulator
SRS16CHR_00493	COG0439	Biotin carboxylase
SRS16CHR_00498	COG2376	Dihydroxyacetone kinase
SRS16CHR_00502	COG1175	transmembrane transport
SRS16CHR_00503	COG0395	ABC-type sugar transport system, permease component
SRS16CHR_00504	COG3842	ATPase activity
SRS16CHR_00505	COG0445	tRNA wobble uridine modification
SRS16CHR_00506	COG1346	cytolysis
SRS16CHR_00507	COG1380	Effector of murein hydrolase LrgA
SRS16CHR_00508	COG0277	FAD linked oxidase domain protein
SRS16CHR_00516	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16CHR_00526	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16CHR_00536	COG0343	queuine tRNA-ribosyltransferase activity
SRS16CHR_00537	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SRS16CHR_00538	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SRS16CHR_00542	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SRS16CHR_00543	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SRS16CHR_00544	COG4770	biotin carboxylase activity
SRS16CHR_00546	COG0783	Belongs to the Dps family
SRS16CHR_00547	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SRS16CHR_00550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SRS16CHR_00551	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SRS16CHR_00552	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SRS16CHR_00553	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SRS16CHR_00554	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SRS16CHR_00555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SRS16CHR_00556	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SRS16CHR_00557	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SRS16CHR_00558	COG1841	ribosomal large subunit assembly
SRS16CHR_00559	COG0200	Binds to the 23S rRNA
SRS16CHR_00560	COG0201	protein transport
SRS16CHR_00561	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SRS16CHR_00562	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SRS16CHR_00563	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SRS16CHR_00564	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SRS16CHR_00565	COG0202	RNA polymerase activity
SRS16CHR_00566	COG0203	ribosomal protein L17
SRS16CHR_00568	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SRS16CHR_00568	COG0506	proline dehydrogenase activity
SRS16CHR_00568	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SRS16CHR_00572	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_00573	COG1024	Enoyl-CoA hydratase
SRS16CHR_00576	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SRS16CHR_00580	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00582	COG0022	dehydrogenase e1 component
SRS16CHR_00583	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SRS16CHR_00586	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SRS16CHR_00587	COG2814	Major facilitator Superfamily
SRS16CHR_00591	COG2814	Major facilitator Superfamily
SRS16CHR_00593	COG1686	Belongs to the peptidase S11 family
SRS16CHR_00599	COG1595	DNA-templated transcription, initiation
SRS16CHR_00604	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_00607	COG0667	Aldo Keto reductase
SRS16CHR_00608	COG0346	lactoylglutathione lyase activity
SRS16CHR_00614	COG4213	ABC transporter substrate-binding protein
SRS16CHR_00615	COG4214	carbohydrate transport
SRS16CHR_00616	COG1129	ABC transporter
SRS16CHR_00624	COG0477	Major facilitator Superfamily
SRS16CHR_00631	COG1022	Amp-dependent synthetase and ligase
SRS16CHR_00632	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SRS16CHR_00634	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00639	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SRS16CHR_00640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SRS16CHR_00641	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SRS16CHR_00642	COG2205	protein histidine kinase activity
SRS16CHR_00643	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_00644	COG1187	pseudouridine synthase activity
SRS16CHR_00646	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_00647	COG0642	Histidine kinase
SRS16CHR_00654	COG0326	Molecular chaperone. Has ATPase activity
SRS16CHR_00655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_00656	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_00657	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_00658	COG0583	DNA-binding transcription factor activity
SRS16CHR_00660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SRS16CHR_00662	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_00664	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_00665	COG2267	carboxylic ester hydrolase activity
SRS16CHR_00668	COG0183	Belongs to the thiolase family
SRS16CHR_00671	COG1764	response to oxidative stress
SRS16CHR_00672	COG1846	Transcriptional regulator
SRS16CHR_00674	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_00675	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SRS16CHR_00679	COG0724	RNA recognition motif
SRS16CHR_00680	COG3530	Putative quorum-sensing-regulated virulence factor
SRS16CHR_00681	COG0513	Belongs to the DEAD box helicase family
SRS16CHR_00683	COG0842	Transport permease protein
SRS16CHR_00684	COG1131	(ABC) transporter
SRS16CHR_00685	COG0583	DNA-binding transcription factor activity
SRS16CHR_00686	COG0625	glutathione transferase activity
SRS16CHR_00688	COG2124	cytochrome p450
SRS16CHR_00689	COG0640	Transcriptional regulator
SRS16CHR_00690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SRS16CHR_00694	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SRS16CHR_00695	COG4208	sulfate ABC transporter
SRS16CHR_00697	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SRS16CHR_00702	COG1652	LysM domain
SRS16CHR_00703	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SRS16CHR_00704	COG2733	membrane
SRS16CHR_00705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRS16CHR_00706	COG1473	amidohydrolase
SRS16CHR_00709	COG0243	molybdopterin cofactor binding
SRS16CHR_00712	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_00726	COG4106	trans-aconitate 2-methyltransferase activity
SRS16CHR_00729	COG2076	Multidrug Resistance protein
SRS16CHR_00731	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SRS16CHR_00732	COG1086	Polysaccharide biosynthesis protein
SRS16CHR_00745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SRS16CHR_00748	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SRS16CHR_00749	COG1216	Glycosyl transferase, family 2
SRS16CHR_00751	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRS16CHR_00755	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SRS16CHR_00755	COG0662	Cupin 2, conserved barrel domain protein
SRS16CHR_00756	COG0438	transferase activity, transferring glycosyl groups
SRS16CHR_00756	COG1216	Glycosyl transferase, family 2
SRS16CHR_00759	COG2755	lipolytic protein G-D-S-L family
SRS16CHR_00759	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SRS16CHR_00761	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SRS16CHR_00762	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SRS16CHR_00764	COG0753	catalase activity
SRS16CHR_00767	COG2119	membrane
SRS16CHR_00769	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SRS16CHR_00772	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SRS16CHR_00776	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_00777	COG1137	ATPase activity
SRS16CHR_00784	COG3064	Membrane
SRS16CHR_00787	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SRS16CHR_00788	COG2721	sulfolactate sulfo-lyase activity
SRS16CHR_00789	COG2186	Transcriptional regulator
SRS16CHR_00790	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00792	COG0765	amino acid transport
SRS16CHR_00793	COG0765	amino acid transport
SRS16CHR_00796	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16CHR_00800	COG2188	Transcriptional regulator
SRS16CHR_00807	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SRS16CHR_00808	COG0066	3-isopropylmalate dehydratase activity
SRS16CHR_00814	COG1053	succinate dehydrogenase
SRS16CHR_00814	COG0431	NADPH-dependent FMN reductase
SRS16CHR_00814	COG3976	FMN-binding domain protein
SRS16CHR_00818	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_00820	COG1024	Enoyl-CoA hydratase
SRS16CHR_00820	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_00821	COG2852	Protein conserved in bacteria
SRS16CHR_00822	COG0183	Belongs to the thiolase family
SRS16CHR_00826	COG1024	Enoyl-CoA hydratase
SRS16CHR_00827	COG1607	acyl-coa hydrolase
SRS16CHR_00828	COG5265	(ABC) transporter
SRS16CHR_00829	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SRS16CHR_00830	COG0583	DNA-binding transcription factor activity
SRS16CHR_00832	COG0765	amino acid transport
SRS16CHR_00833	COG0765	amino acid transport
SRS16CHR_00834	COG1126	abc transporter atp-binding protein
SRS16CHR_00835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SRS16CHR_00838	COG1280	lysine exporter protein (LysE YggA)
SRS16CHR_00840	COG2003	Belongs to the UPF0758 family
SRS16CHR_00842	COG0418	dihydroorotase activity
SRS16CHR_00844	COG0501	Belongs to the peptidase M48B family
SRS16CHR_00845	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SRS16CHR_00852	COG1187	pseudouridine synthase activity
SRS16CHR_00853	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SRS16CHR_00855	COG1030	water channel activity
SRS16CHR_00856	COG0330	HflC and HflK could
SRS16CHR_00857	COG0598	Magnesium transport protein CorA
SRS16CHR_00860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SRS16CHR_00862	COG2807	transmembrane transport
SRS16CHR_00865	COG2175	clavaminate synthase activity
SRS16CHR_00868	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRS16CHR_00871	COG2175	clavaminate synthase activity
SRS16CHR_00880	COG0596	Alpha beta hydrolase
SRS16CHR_00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRS16CHR_00882	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SRS16CHR_00884	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_00886	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SRS16CHR_00889	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SRS16CHR_00890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SRS16CHR_00891	COG0523	cobalamin synthesis protein
SRS16CHR_00894	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SRS16CHR_00895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SRS16CHR_00896	COG2001	Belongs to the MraZ family
SRS16CHR_00897	COG0275	rRNA processing
SRS16CHR_00900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SRS16CHR_00901	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SRS16CHR_00902	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SRS16CHR_00903	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SRS16CHR_00904	COG0772	Belongs to the SEDS family
SRS16CHR_00905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SRS16CHR_00906	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SRS16CHR_00907	COG1181	Belongs to the D-alanine--D-alanine ligase family
SRS16CHR_00908	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SRS16CHR_00910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SRS16CHR_00911	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SRS16CHR_00913	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SRS16CHR_00914	COG0575	Belongs to the CDS family
SRS16CHR_00916	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SRS16CHR_00917	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SRS16CHR_00920	COG3150	esterase
SRS16CHR_00921	COG2197	response regulator
SRS16CHR_00923	COG0772	Belongs to the SEDS family
SRS16CHR_00924	COG0312	modulator of DNA gyrase
SRS16CHR_00925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SRS16CHR_00927	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SRS16CHR_00930	COG0511	ligase activity, forming carbon-carbon bonds
SRS16CHR_00931	COG0439	Biotin carboxylase
SRS16CHR_00932	COG2264	protein methyltransferase activity
SRS16CHR_00934	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SRS16CHR_00936	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SRS16CHR_00943	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SRS16CHR_00944	COG2943	transferase activity, transferring hexosyl groups
SRS16CHR_00944	COG3416	Protein conserved in bacteria
SRS16CHR_00946	COG2204	response regulator
SRS16CHR_00948	COG2205	protein histidine kinase activity
SRS16CHR_00949	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SRS16CHR_00951	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_00952	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_00959	COG0037	tRNA processing
SRS16CHR_00961	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_00963	COG2175	clavaminate synthase activity
SRS16CHR_00965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SRS16CHR_00966	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_00971	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SRS16CHR_00973	COG0617	tRNA 3'-terminal CCA addition
SRS16CHR_00976	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SRS16CHR_00977	COG0583	DNA-binding transcription factor activity
SRS16CHR_00979	COG2200	EAL domain
SRS16CHR_00980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SRS16CHR_00983	COG0110	maltose O-acetyltransferase activity
SRS16CHR_00984	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SRS16CHR_00985	COG1522	sequence-specific DNA binding
SRS16CHR_00987	COG1254	Belongs to the acylphosphatase family
SRS16CHR_00994	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_00995	COG0183	Belongs to the thiolase family
SRS16CHR_00999	COG0515	serine threonine protein kinase
SRS16CHR_00999	COG2815	serine threonine protein kinase
SRS16CHR_01001	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRS16CHR_01002	COG4597	amino acid ABC transporter
SRS16CHR_01003	COG0765	amino acid transport
SRS16CHR_01004	COG1126	abc transporter atp-binding protein
SRS16CHR_01010	COG2072	flavoprotein involved in K transport
SRS16CHR_01013	COG5002	protein histidine kinase activity
SRS16CHR_01013	COG5001	Diguanylate cyclase
SRS16CHR_01013	COG3447	MASE1 domain protein
SRS16CHR_01015	COG0129	dihydroxy-acid dehydratase activity
SRS16CHR_01018	COG3386	PFAM SMP-30 Gluconolaconase
SRS16CHR_01020	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_01021	COG1879	ABC-type sugar transport system periplasmic component
SRS16CHR_01024	COG4214	carbohydrate transport
SRS16CHR_01025	COG1129	ABC transporter
SRS16CHR_01026	COG1172	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_01027	COG1172	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_01033	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SRS16CHR_01033	COG0189	ligase activity
SRS16CHR_01034	COG0189	ligase activity
SRS16CHR_01034	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SRS16CHR_01035	COG1132	(ABC) transporter
SRS16CHR_01037	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SRS16CHR_01038	COG4178	(ABC) transporter
SRS16CHR_01040	COG1459	type II secretion system
SRS16CHR_01049	COG4970	Tfp pilus assembly protein FimT
SRS16CHR_01052	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SRS16CHR_01054	COG1765	OsmC-like protein
SRS16CHR_01055	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SRS16CHR_01058	COG1473	amidohydrolase
SRS16CHR_01059	COG4166	transmembrane transport
SRS16CHR_01060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SRS16CHR_01061	COG0444	Belongs to the ABC transporter superfamily
SRS16CHR_01062	COG4608	Belongs to the ABC transporter superfamily
SRS16CHR_01063	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SRS16CHR_01064	COG1840	ABC-type Fe3 transport system, periplasmic component
SRS16CHR_01066	COG3842	ATPase activity
SRS16CHR_01069	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SRS16CHR_01070	COG0166	Belongs to the GPI family
SRS16CHR_01071	COG0439	Biotin carboxylase
SRS16CHR_01072	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_01075	COG1802	Transcriptional regulator
SRS16CHR_01078	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SRS16CHR_01081	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SRS16CHR_01082	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SRS16CHR_01083	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_01084	COG5002	protein histidine kinase activity
SRS16CHR_01085	COG0459	protein refolding
SRS16CHR_01086	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SRS16CHR_01087	COG2186	Transcriptional regulator
SRS16CHR_01088	COG2807	transmembrane transport
SRS16CHR_01089	COG0456	acetyltransferase
SRS16CHR_01093	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_01094	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_01096	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_01101	COG2207	Transcriptional regulator
SRS16CHR_01103	COG0625	glutathione transferase activity
SRS16CHR_01107	COG4772	TonB-dependent receptor
SRS16CHR_01109	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SRS16CHR_01111	COG1560	Kdo2-lipid A biosynthetic process
SRS16CHR_01113	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SRS16CHR_01115	COG1333	cytochrome c biogenesis protein
SRS16CHR_01116	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SRS16CHR_01117	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SRS16CHR_01118	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SRS16CHR_01121	COG1965	Belongs to the frataxin family
SRS16CHR_01128	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SRS16CHR_01130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SRS16CHR_01135	COG0069	glutamate synthase activity
SRS16CHR_01135	COG0067	glutamate synthase
SRS16CHR_01135	COG0070	glutamate synthase
SRS16CHR_01137	COG1127	ABC transporter
SRS16CHR_01138	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SRS16CHR_01139	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SRS16CHR_01143	COG1131	(ABC) transporter
SRS16CHR_01144	COG0842	Transport permease protein
SRS16CHR_01145	COG5007	Belongs to the BolA IbaG family
SRS16CHR_01146	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SRS16CHR_01147	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SRS16CHR_01148	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SRS16CHR_01150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SRS16CHR_01151	COG0131	Imidazoleglycerol-phosphate dehydratase
SRS16CHR_01153	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SRS16CHR_01155	COG1301	dicarboxylic acid transport
SRS16CHR_01157	COG0107	imidazoleglycerol-phosphate synthase activity
SRS16CHR_01158	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SRS16CHR_01159	COG0140	phosphoribosyl-ATP diphosphatase activity
SRS16CHR_01161	COG0537	adenosine 5'-monophosphoramidase activity
SRS16CHR_01162	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SRS16CHR_01163	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SRS16CHR_01164	COG0805	protein transport
SRS16CHR_01165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRS16CHR_01166	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SRS16CHR_01167	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SRS16CHR_01168	COG1970	mechanosensitive ion channel activity
SRS16CHR_01169	COG0723	plastoquinol--plastocyanin reductase activity
SRS16CHR_01170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SRS16CHR_01171	COG2857	Cytochrome c1
SRS16CHR_01172	COG0625	glutathione transferase activity
SRS16CHR_01173	COG2969	positive regulation of protein catabolic process
SRS16CHR_01175	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_01177	COG1309	transcriptional regulator
SRS16CHR_01180	COG0653	protein targeting
SRS16CHR_01181	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SRS16CHR_01183	COG0494	nUDIX hydrolase
SRS16CHR_01185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SRS16CHR_01186	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
SRS16CHR_01188	COG1696	Membrane protein involved in D-alanine export
SRS16CHR_01194	COG0142	geranyltranstransferase activity
SRS16CHR_01195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SRS16CHR_01196	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SRS16CHR_01197	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SRS16CHR_01198	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SRS16CHR_01200	COG0494	nUDIX hydrolase
SRS16CHR_01201	COG0442	prolyl-tRNA aminoacylation
SRS16CHR_01202	COG0741	lytic transglycosylase activity
SRS16CHR_01203	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SRS16CHR_01205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SRS16CHR_01206	COG2890	protein-(glutamine-N5) methyltransferase activity
SRS16CHR_01207	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SRS16CHR_01208	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SRS16CHR_01210	COG1511	domain protein
SRS16CHR_01210	COG3264	Mechanosensitive ion channel
SRS16CHR_01211	COG0584	glycerophosphoryl diester phosphodiesterase
SRS16CHR_01212	COG3842	ATPase activity
SRS16CHR_01213	COG0395	ABC-type sugar transport system, permease component
SRS16CHR_01214	COG1175	transmembrane transport
SRS16CHR_01216	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRS16CHR_01220	COG2226	methyltransferase
SRS16CHR_01223	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SRS16CHR_01224	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SRS16CHR_01225	COG3842	ATPase activity
SRS16CHR_01226	COG1176	ABC-type spermidine putrescine transport system, permease component I
SRS16CHR_01227	COG1177	transmembrane transport
SRS16CHR_01230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SRS16CHR_01232	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_01235	COG3568	Endonuclease Exonuclease Phosphatase
SRS16CHR_01236	COG0302	gtp cyclohydrolase
SRS16CHR_01238	COG2076	Multidrug Resistance protein
SRS16CHR_01246	COG4585	Histidine kinase
SRS16CHR_01247	COG2197	response regulator
SRS16CHR_01249	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SRS16CHR_01250	COG0793	Belongs to the peptidase S41A family
SRS16CHR_01251	COG0588	phosphoglycerate mutase activity
SRS16CHR_01252	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SRS16CHR_01254	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SRS16CHR_01255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SRS16CHR_01257	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SRS16CHR_01259	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SRS16CHR_01260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SRS16CHR_01261	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SRS16CHR_01262	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SRS16CHR_01268	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SRS16CHR_01268	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SRS16CHR_01269	COG3132	Protein of unknown function, DUF480
SRS16CHR_01272	COG0489	protein tyrosine kinase activity
SRS16CHR_01273	COG2223	nitrite transmembrane transporter activity
SRS16CHR_01275	COG3383	formate dehydrogenase (NAD+) activity
SRS16CHR_01280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SRS16CHR_01281	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SRS16CHR_01282	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_01285	COG2003	Belongs to the UPF0758 family
SRS16CHR_01286	COG1047	Peptidyl-prolyl cis-trans
SRS16CHR_01287	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SRS16CHR_01290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SRS16CHR_01294	COG0242	peptide deformylase activity
SRS16CHR_01297	COG4638	Rieske (2fe-2S)
SRS16CHR_01301	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SRS16CHR_01305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SRS16CHR_01314	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_01320	COG1063	alcohol dehydrogenase
SRS16CHR_01322	COG3328	transposase activity
SRS16CHR_01326	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_01337	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_01338	COG3246	L-lysine catabolic process to acetate
SRS16CHR_01340	COG1176	ABC-type spermidine putrescine transport system, permease component I
SRS16CHR_01341	COG1177	transmembrane transport
SRS16CHR_01346	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SRS16CHR_01349	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16CHR_01350	COG2175	clavaminate synthase activity
SRS16CHR_01357	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRS16CHR_01357	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRS16CHR_01358	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRS16CHR_01358	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRS16CHR_01359	COG1024	Enoyl-CoA hydratase
SRS16CHR_01363	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SRS16CHR_01369	COG3128	pkhd-type hydroxylase
SRS16CHR_01370	COG4774	siderophore transport
SRS16CHR_01371	COG5002	protein histidine kinase activity
SRS16CHR_01372	COG2197	response regulator
SRS16CHR_01373	COG0180	Tryptophanyl-tRNA synthetase
SRS16CHR_01374	COG1994	Peptidase M50
SRS16CHR_01375	COG0009	L-threonylcarbamoyladenylate synthase
SRS16CHR_01377	COG0613	PHP domain protein
SRS16CHR_01379	COG0306	phosphate transporter
SRS16CHR_01386	COG1129	ABC transporter
SRS16CHR_01388	COG3540	Alkaline phosphatase
SRS16CHR_01393	COG0477	Major facilitator Superfamily
SRS16CHR_01394	COG0829	nickel cation binding
SRS16CHR_01402	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SRS16CHR_01416	COG0163	prenyltransferase activity
SRS16CHR_01417	COG0523	cobalamin synthesis protein
SRS16CHR_01418	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SRS16CHR_01418	COG2080	2 iron, 2 sulfur cluster binding
SRS16CHR_01421	COG0583	DNA-binding transcription factor activity
SRS16CHR_01422	COG2233	PERMEase
SRS16CHR_01423	COG0280	phosphate acetyltransferase
SRS16CHR_01423	COG0281	malic enzyme
SRS16CHR_01424	COG2084	Dehydrogenase
SRS16CHR_01425	COG3622	Belongs to the hyi family
SRS16CHR_01426	COG3960	tartronate-semialdehyde synthase activity
SRS16CHR_01427	COG0583	DNA-binding transcription factor activity
SRS16CHR_01430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SRS16CHR_01431	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_01432	COG0251	oxidation-reduction process
SRS16CHR_01434	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRS16CHR_01435	COG3971	2-oxopent-4-enoate hydratase activity
SRS16CHR_01437	COG3548	integral membrane protein
SRS16CHR_01441	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRS16CHR_01442	COG0439	Biotin carboxylase
SRS16CHR_01445	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_01449	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_01465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SRS16CHR_01466	COG2801	Transposase and inactivated derivatives
SRS16CHR_01473	COG0628	permease
SRS16CHR_01474	COG2186	Transcriptional regulator
SRS16CHR_01475	COG1301	dicarboxylic acid transport
SRS16CHR_01476	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SRS16CHR_01481	COG0656	L-ascorbic acid biosynthetic process
SRS16CHR_01482	COG1953	Uracil, thiamine, allantoin
SRS16CHR_01483	COG2233	PERMEase
SRS16CHR_01486	COG1953	Uracil, thiamine, allantoin
SRS16CHR_01490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRS16CHR_01493	COG2186	Transcriptional regulator
SRS16CHR_01506	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SRS16CHR_01509	COG2133	pyrroloquinoline quinone binding
SRS16CHR_01511	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SRS16CHR_01512	COG1021	2,3-dihydroxybenzoate-AMP ligase
SRS16CHR_01519	COG1320	monovalent cation:proton antiporter activity
SRS16CHR_01520	COG2212	antiporter activity
SRS16CHR_01522	COG0651	ATP synthesis coupled electron transport
SRS16CHR_01523	COG1006	Multisubunit Na H antiporter MnhC subunit
SRS16CHR_01524	COG2111	Na H antiporter
SRS16CHR_01524	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SRS16CHR_01525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SRS16CHR_01527	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SRS16CHR_01531	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SRS16CHR_01532	COG0287	Prephenate dehydrogenase
SRS16CHR_01534	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SRS16CHR_01538	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SRS16CHR_01544	COG4797	methyltransferase
SRS16CHR_01544	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SRS16CHR_01546	COG1187	pseudouridine synthase activity
SRS16CHR_01551	COG1546	Belongs to the CinA family
SRS16CHR_01551	COG1058	Belongs to the CinA family
SRS16CHR_01552	COG0174	glutamine synthetase
SRS16CHR_01554	COG3852	Histidine kinase
SRS16CHR_01555	COG2204	response regulator
SRS16CHR_01557	COG0708	Exodeoxyribonuclease III
SRS16CHR_01558	COG1956	GAF domain-containing protein
SRS16CHR_01564	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRS16CHR_01570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SRS16CHR_01572	COG0277	FAD linked oxidase domain protein
SRS16CHR_01574	COG1295	ribonuclease BN
SRS16CHR_01575	COG3118	belongs to the thioredoxin family
SRS16CHR_01584	COG1538	Outer membrane efflux protein
SRS16CHR_01587	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SRS16CHR_01588	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_01591	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SRS16CHR_01592	COG0596	Alpha beta hydrolase
SRS16CHR_01594	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SRS16CHR_01595	COG2818	Glycosylase
SRS16CHR_01596	COG2719	SpoVR family
SRS16CHR_01597	COG2718	Belongs to the UPF0229 family
SRS16CHR_01598	COG2766	serine protein kinase
SRS16CHR_01599	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRS16CHR_01600	COG2186	Transcriptional regulator
SRS16CHR_01605	COG0673	inositol 2-dehydrogenase activity
SRS16CHR_01608	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SRS16CHR_01617	COG0484	heat shock protein binding
SRS16CHR_01618	COG0443	Heat shock 70 kDa protein
SRS16CHR_01619	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SRS16CHR_01622	COG0688	phosphatidylethanolamine metabolic process
SRS16CHR_01624	COG2721	sulfolactate sulfo-lyase activity
SRS16CHR_01625	COG2706	6-phosphogluconolactonase activity
SRS16CHR_01628	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SRS16CHR_01629	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRS16CHR_01630	COG2186	Transcriptional regulator
SRS16CHR_01632	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SRS16CHR_01633	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_01638	COG2188	Transcriptional regulator
SRS16CHR_01639	COG0683	leucine binding
SRS16CHR_01642	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_01644	COG1129	ABC transporter
SRS16CHR_01649	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_01651	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SRS16CHR_01656	COG1137	ATPase activity
SRS16CHR_01662	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SRS16CHR_01666	COG0517	IMP dehydrogenase activity
SRS16CHR_01666	COG1125	glycine betaine transport
SRS16CHR_01667	COG2814	Major facilitator Superfamily
SRS16CHR_01669	COG0358	DNA primase activity
SRS16CHR_01670	COG1295	ribonuclease BN
SRS16CHR_01675	COG3237	CsbD-like
SRS16CHR_01676	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SRS16CHR_01681	COG1611	Belongs to the LOG family
SRS16CHR_01682	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SRS16CHR_01684	COG0322	excinuclease ABC activity
SRS16CHR_01687	COG0473	3-isopropylmalate dehydrogenase activity
SRS16CHR_01690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SRS16CHR_01694	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SRS16CHR_01695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SRS16CHR_01698	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SRS16CHR_01699	COG0670	Belongs to the BI1 family
SRS16CHR_01700	COG3193	protein, possibly involved in utilization of glycolate and propanediol
SRS16CHR_01705	COG3128	pkhd-type hydroxylase
SRS16CHR_01706	COG4774	siderophore transport
SRS16CHR_01707	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SRS16CHR_01708	COG1477	protein flavinylation
SRS16CHR_01714	COG3634	alkyl hydroperoxide reductase activity
SRS16CHR_01717	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SRS16CHR_01720	COG0360	Binds together with S18 to 16S ribosomal RNA
SRS16CHR_01721	COG2965	DNA replication, synthesis of RNA primer
SRS16CHR_01722	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SRS16CHR_01723	COG0359	binds to the 23S rRNA
SRS16CHR_01729	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SRS16CHR_01730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SRS16CHR_01732	COG0436	Aminotransferase
SRS16CHR_01735	COG1763	Mo-molybdopterin cofactor biosynthetic process
SRS16CHR_01736	COG0303	'Molybdopterin
SRS16CHR_01737	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SRS16CHR_01738	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SRS16CHR_01739	COG0314	molybdopterin synthase activity
SRS16CHR_01740	COG0583	DNA-binding transcription factor activity
SRS16CHR_01744	COG0542	response to heat
SRS16CHR_01752	COG0431	NADPH-dependent FMN reductase
SRS16CHR_01761	COG3214	Protein conserved in bacteria
SRS16CHR_01763	COG2084	Dehydrogenase
SRS16CHR_01767	COG0673	inositol 2-dehydrogenase activity
SRS16CHR_01772	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_01773	COG1309	transcriptional regulator
SRS16CHR_01774	COG0028	Belongs to the TPP enzyme family
SRS16CHR_01777	COG2224	Isocitrate lyase
SRS16CHR_01778	COG2246	polysaccharide biosynthetic process
SRS16CHR_01779	COG0546	phosphoglycolate phosphatase activity
SRS16CHR_01779	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SRS16CHR_01781	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SRS16CHR_01782	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SRS16CHR_01783	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SRS16CHR_01784	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SRS16CHR_01785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SRS16CHR_01786	COG0072	phenylalanine-tRNA ligase activity
SRS16CHR_01786	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SRS16CHR_01787	COG0776	regulation of translation
SRS16CHR_01802	COG0740	serine-type endopeptidase activity
SRS16CHR_01808	COG0025	NhaP-type Na H and K H
SRS16CHR_01809	COG0667	Aldo Keto reductase
SRS16CHR_01811	COG0583	DNA-binding transcription factor activity
SRS16CHR_01814	COG2301	Belongs to the HpcH HpaI aldolase family
SRS16CHR_01815	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_01816	COG1024	Enoyl-CoA hydratase
SRS16CHR_01817	COG0427	acetyl-CoA hydrolase
SRS16CHR_01820	COG0583	DNA-binding transcription factor activity
SRS16CHR_01821	COG1968	undecaprenyl-diphosphatase activity
SRS16CHR_01826	COG1132	(ABC) transporter
SRS16CHR_01827	COG3045	CreA protein
SRS16CHR_01833	COG3243	poly(R)-hydroxyalkanoic acid synthase
SRS16CHR_01834	COG0183	Belongs to the thiolase family
SRS16CHR_01835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16CHR_01836	COG0477	Major facilitator Superfamily
SRS16CHR_01837	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_01838	COG1301	dicarboxylic acid transport
SRS16CHR_01839	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SRS16CHR_01839	COG4651	solute:proton antiporter activity
SRS16CHR_01842	COG1070	Carbohydrate kinase
SRS16CHR_01843	COG2207	Transcriptional regulator
SRS16CHR_01843	COG4753	response regulator
SRS16CHR_01845	COG0246	Mannitol dehydrogenase
SRS16CHR_01847	COG0395	ABC-type sugar transport system, permease component
SRS16CHR_01848	COG1175	transmembrane transport
SRS16CHR_01858	COG2165	general secretion pathway protein
SRS16CHR_01874	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_01877	COG0477	Major facilitator Superfamily
SRS16CHR_01879	COG1917	Cupin 2, conserved barrel domain protein
SRS16CHR_01879	COG2169	Transcriptional regulator
SRS16CHR_01880	COG3976	FMN-binding domain protein
SRS16CHR_01880	COG1053	succinate dehydrogenase
SRS16CHR_01881	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SRS16CHR_01883	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16CHR_01885	COG1126	abc transporter atp-binding protein
SRS16CHR_01886	COG0765	amino acid transport
SRS16CHR_01888	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_01889	COG1802	Transcriptional regulator
SRS16CHR_01890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRS16CHR_01890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SRS16CHR_01891	COG1703	isobutyryl-CoA mutase activity
SRS16CHR_01892	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRS16CHR_01893	COG4770	biotin carboxylase activity
SRS16CHR_01896	COG2878	Part of a membrane complex involved in electron transport
SRS16CHR_01899	COG0556	nucleotide-excision repair
SRS16CHR_01900	COG1959	2 iron, 2 sulfur cluster binding
SRS16CHR_01901	COG1104	cysteine desulfurase activity
SRS16CHR_01902	COG0822	iron-sulfur transferase activity
SRS16CHR_01904	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SRS16CHR_01905	COG0443	Heat shock 70 kDa protein
SRS16CHR_01907	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SRS16CHR_01912	COG0167	dihydroorotate dehydrogenase activity
SRS16CHR_01913	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SRS16CHR_01916	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SRS16CHR_01917	COG4566	intracellular signal transduction
SRS16CHR_01918	COG4191	Histidine kinase
SRS16CHR_01919	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SRS16CHR_01920	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRS16CHR_01921	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SRS16CHR_01922	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SRS16CHR_01923	COG0791	NLP P60 protein
SRS16CHR_01924	COG2133	pyrroloquinoline quinone binding
SRS16CHR_01926	COG2368	4-hydroxyphenylacetate
SRS16CHR_01932	COG0567	Dehydrogenase, E1 component
SRS16CHR_01933	COG0508	dehydrogenase complex catalyzes the overall conversion of
SRS16CHR_01934	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SRS16CHR_01935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SRS16CHR_01938	COG1199	ATP-dependent helicase activity
SRS16CHR_01940	COG0564	pseudouridine synthase activity
SRS16CHR_01941	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SRS16CHR_01942	COG1187	pseudouridine synthase activity
SRS16CHR_01943	COG0105	UTP biosynthetic process
SRS16CHR_01944	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SRS16CHR_01947	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SRS16CHR_01948	COG0124	histidyl-tRNA synthetase
SRS16CHR_01950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SRS16CHR_01951	COG1160	GTP binding
SRS16CHR_01952	COG1923	regulation of RNA biosynthetic process
SRS16CHR_01953	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SRS16CHR_01954	COG0330	HflC and HflK could
SRS16CHR_01955	COG0330	HflC and HflK could
SRS16CHR_01957	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SRS16CHR_01958	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SRS16CHR_01960	COG0626	cystathionine gamma-synthase activity
SRS16CHR_01963	COG1136	(ABC) transporter
SRS16CHR_01964	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SRS16CHR_01966	COG3618	amidohydrolase
SRS16CHR_01967	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_01973	COG0667	Aldo Keto reductase
SRS16CHR_01976	COG1295	ribonuclease BN
SRS16CHR_01977	COG3119	arylsulfatase activity
SRS16CHR_01979	COG0583	DNA-binding transcription factor activity
SRS16CHR_01982	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SRS16CHR_01986	COG2951	lytic endotransglycosylase activity
SRS16CHR_01989	COG0714	Associated with various cellular activities
SRS16CHR_01991	COG1196	nuclear chromosome segregation
SRS16CHR_01991	COG3264	Mechanosensitive ion channel
SRS16CHR_01994	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_02000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SRS16CHR_02005	COG1414	Transcriptional regulator
SRS16CHR_02006	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SRS16CHR_02008	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SRS16CHR_02010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SRS16CHR_02011	COG2814	Major facilitator Superfamily
SRS16CHR_02018	COG0583	DNA-binding transcription factor activity
SRS16CHR_02021	COG1116	anion transmembrane transporter activity
SRS16CHR_02024	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SRS16CHR_02030	COG3384	dioxygenase
SRS16CHR_02034	COG3384	dioxygenase
SRS16CHR_02037	COG4941	Belongs to the sigma-70 factor family
SRS16CHR_02038	COG3795	YCII-related domain
SRS16CHR_02047	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SRS16CHR_02047	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SRS16CHR_02048	COG0509	glycine decarboxylation via glycine cleavage system
SRS16CHR_02049	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SRS16CHR_02052	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02055	COG0642	Histidine kinase
SRS16CHR_02056	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_02058	COG2194	sulfuric ester hydrolase activity
SRS16CHR_02063	COG4302	ethanolamine ammonia-lyase activity
SRS16CHR_02064	COG4303	Ethanolamine ammonia lyase large subunit
SRS16CHR_02068	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SRS16CHR_02069	COG2169	Transcriptional regulator
SRS16CHR_02069	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SRS16CHR_02076	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_02082	COG1024	Enoyl-CoA hydratase
SRS16CHR_02084	COG0583	DNA-binding transcription factor activity
SRS16CHR_02085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SRS16CHR_02087	COG1396	sequence-specific DNA binding
SRS16CHR_02087	COG3800	Transcriptional regulator
SRS16CHR_02090	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_02095	COG2366	antibiotic biosynthetic process
SRS16CHR_02096	COG1183	phosphatidylcholine synthase activity
SRS16CHR_02097	COG0519	Catalyzes the synthesis of GMP from XMP
SRS16CHR_02098	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SRS16CHR_02100	COG1132	(ABC) transporter
SRS16CHR_02101	COG3384	dioxygenase
SRS16CHR_02110	COG0587	DNA-directed DNA polymerase activity
SRS16CHR_02112	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SRS16CHR_02113	COG4608	Belongs to the ABC transporter superfamily
SRS16CHR_02114	COG0444	Belongs to the ABC transporter superfamily
SRS16CHR_02115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SRS16CHR_02116	COG0601	transmembrane transport
SRS16CHR_02117	COG0747	negative chemotaxis
SRS16CHR_02124	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SRS16CHR_02125	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02128	COG0589	response to stress
SRS16CHR_02129	COG2217	Heavy metal translocating P-type atpase
SRS16CHR_02131	COG3278	Belongs to the heme-copper respiratory oxidase family
SRS16CHR_02138	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SRS16CHR_02139	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SRS16CHR_02142	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SRS16CHR_02147	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SRS16CHR_02149	COG4191	Histidine kinase
SRS16CHR_02149	COG0784	Response regulator, receiver
SRS16CHR_02155	COG0589	response to stress
SRS16CHR_02156	COG0589	response to stress
SRS16CHR_02158	COG0589	response to stress
SRS16CHR_02162	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRS16CHR_02164	COG1914	H( )-stimulated, divalent metal cation uptake system
SRS16CHR_02165	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SRS16CHR_02166	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SRS16CHR_02167	COG3328	transposase activity
SRS16CHR_02171	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_02172	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_02175	COG3038	cytochrome b561
SRS16CHR_02193	COG2204	response regulator
SRS16CHR_02195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SRS16CHR_02199	COG2267	carboxylic ester hydrolase activity
SRS16CHR_02202	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16CHR_02208	COG1414	Transcriptional regulator
SRS16CHR_02209	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02210	COG0028	Belongs to the TPP enzyme family
SRS16CHR_02211	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
SRS16CHR_02212	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_02219	COG2271	Major facilitator Superfamily
SRS16CHR_02223	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SRS16CHR_02224	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SRS16CHR_02225	COG0493	'glutamate synthase
SRS16CHR_02225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SRS16CHR_02227	COG1741	Belongs to the pirin family
SRS16CHR_02228	COG2259	Doxx family
SRS16CHR_02230	COG1741	Belongs to the pirin family
SRS16CHR_02234	COG0848	biopolymer transport protein
SRS16CHR_02236	COG0824	Thioesterase
SRS16CHR_02237	COG0436	Aminotransferase
SRS16CHR_02238	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SRS16CHR_02239	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SRS16CHR_02242	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SRS16CHR_02242	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SRS16CHR_02249	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SRS16CHR_02250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SRS16CHR_02251	COG0741	lytic transglycosylase activity
SRS16CHR_02254	COG3228	Belongs to the MtfA family
SRS16CHR_02255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SRS16CHR_02259	COG0215	cysteine-tRNA ligase activity
SRS16CHR_02261	COG0825	malonyl-CoA metabolic process
SRS16CHR_02262	COG0037	tRNA processing
SRS16CHR_02265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SRS16CHR_02265	COG2755	lipolytic protein G-D-S-L family
SRS16CHR_02266	COG1609	Transcriptional regulator
SRS16CHR_02267	COG1063	alcohol dehydrogenase
SRS16CHR_02268	COG1070	Carbohydrate kinase
SRS16CHR_02271	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SRS16CHR_02271	COG1116	anion transmembrane transporter activity
SRS16CHR_02272	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_02277	COG1525	nuclease
SRS16CHR_02278	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SRS16CHR_02279	COG1024	Enoyl-CoA hydratase
SRS16CHR_02279	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_02280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SRS16CHR_02281	COG3321	synthase
SRS16CHR_02281	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02281	COG0604	alcohol dehydrogenase
SRS16CHR_02287	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SRS16CHR_02288	COG4638	Rieske (2fe-2S)
SRS16CHR_02293	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SRS16CHR_02301	COG0411	ABC transporter
SRS16CHR_02303	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_02304	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02309	COG2326	polyphosphate kinase activity
SRS16CHR_02311	COG0642	Histidine kinase
SRS16CHR_02313	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_02319	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_02321	COG2204	response regulator
SRS16CHR_02324	COG1126	abc transporter atp-binding protein
SRS16CHR_02329	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SRS16CHR_02330	COG1011	Hydrolase
SRS16CHR_02332	COG2124	cytochrome p450
SRS16CHR_02335	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02344	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02345	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02349	COG2124	cytochrome p450
SRS16CHR_02351	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_02360	COG0655	NAD(P)H dehydrogenase (quinone) activity
SRS16CHR_02364	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02366	COG2814	Major facilitator Superfamily
SRS16CHR_02368	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_02374	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SRS16CHR_02378	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_02379	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_02381	COG0544	peptidyl-prolyl cis-trans isomerase activity
SRS16CHR_02382	COG0740	serine-type endopeptidase activity
SRS16CHR_02383	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SRS16CHR_02384	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SRS16CHR_02391	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SRS16CHR_02394	COG0114	fumarate hydratase activity
SRS16CHR_02396	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRS16CHR_02398	COG4654	Cytochrome c, class I
SRS16CHR_02400	COG0129	dihydroxy-acid dehydratase activity
SRS16CHR_02401	COG0583	DNA-binding transcription factor activity
SRS16CHR_02402	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SRS16CHR_02404	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_02410	COG4206	TonB-dependent receptor
SRS16CHR_02411	COG1797	cobyrinic acid a,c-diamide synthase activity
SRS16CHR_02413	COG4607	ABC-type enterochelin transport system periplasmic component
SRS16CHR_02415	COG1121	(ABC) transporter
SRS16CHR_02416	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SRS16CHR_02417	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SRS16CHR_02423	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_02425	COG1538	Outer membrane efflux protein
SRS16CHR_02427	COG1492	cobalamin metabolic process
SRS16CHR_02428	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SRS16CHR_02429	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SRS16CHR_02431	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SRS16CHR_02432	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SRS16CHR_02434	COG0626	cystathionine gamma-synthase activity
SRS16CHR_02435	COG0560	Phosphoserine phosphatase
SRS16CHR_02436	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SRS16CHR_02437	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SRS16CHR_02437	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SRS16CHR_02438	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SRS16CHR_02438	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SRS16CHR_02439	COG2205	protein histidine kinase activity
SRS16CHR_02440	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_02443	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SRS16CHR_02447	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
SRS16CHR_02448	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SRS16CHR_02450	COG0557	exoribonuclease II activity
SRS16CHR_02451	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02455	COG0052	Belongs to the universal ribosomal protein uS2 family
SRS16CHR_02456	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SRS16CHR_02457	COG0528	UMP kinase activity
SRS16CHR_02458	COG0233	cytoplasmic translational termination
SRS16CHR_02460	COG0575	Belongs to the CDS family
SRS16CHR_02461	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SRS16CHR_02462	COG0750	zinc metalloprotease
SRS16CHR_02465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SRS16CHR_02466	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SRS16CHR_02467	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SRS16CHR_02468	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SRS16CHR_02469	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SRS16CHR_02470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SRS16CHR_02471	COG0505	Belongs to the CarA family
SRS16CHR_02472	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SRS16CHR_02474	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SRS16CHR_02477	COG1534	Rna-binding protein
SRS16CHR_02478	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SRS16CHR_02479	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SRS16CHR_02481	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SRS16CHR_02486	COG1024	Enoyl-CoA hydratase
SRS16CHR_02487	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_02489	COG2814	Major facilitator Superfamily
SRS16CHR_02490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRS16CHR_02492	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SRS16CHR_02493	COG0252	asparaginase activity
SRS16CHR_02494	COG0563	adenylate kinase activity
SRS16CHR_02495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SRS16CHR_02496	COG2835	tetraacyldisaccharide 4'-kinase activity
SRS16CHR_02497	COG1663	tetraacyldisaccharide 4'-kinase activity
SRS16CHR_02498	COG0848	biopolymer transport protein
SRS16CHR_02499	COG0811	peptide transport
SRS16CHR_02500	COG1570	exodeoxyribonuclease VII activity
SRS16CHR_02501	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SRS16CHR_02505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SRS16CHR_02506	COG0542	response to heat
SRS16CHR_02507	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_02508	COG2925	Exonuclease
SRS16CHR_02511	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SRS16CHR_02511	COG0456	acetyltransferase
SRS16CHR_02514	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_02516	COG5002	protein histidine kinase activity
SRS16CHR_02519	COG3038	cytochrome b561
SRS16CHR_02524	COG3039	Transposase
SRS16CHR_02528	COG4774	siderophore transport
SRS16CHR_02530	COG4585	Histidine kinase
SRS16CHR_02531	COG0402	S-adenosylhomocysteine deaminase activity
SRS16CHR_02532	COG0583	DNA-binding transcription factor activity
SRS16CHR_02534	COG1024	Enoyl-CoA hydratase
SRS16CHR_02537	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_02540	COG5001	Diguanylate cyclase
SRS16CHR_02540	COG3300	MHYT domain
SRS16CHR_02541	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SRS16CHR_02544	COG0433	COG0433 Predicted ATPase
SRS16CHR_02547	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SRS16CHR_02559	COG0217	transcriptional regulatory protein
SRS16CHR_02560	COG0151	Belongs to the GarS family
SRS16CHR_02561	COG0408	coproporphyrinogen oxidase activity
SRS16CHR_02562	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SRS16CHR_02563	COG0799	negative regulation of ribosome biogenesis
SRS16CHR_02564	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SRS16CHR_02565	COG0424	maF-like protein
SRS16CHR_02566	COG1530	ribonuclease E activity
SRS16CHR_02567	COG1132	(ABC) transporter
SRS16CHR_02568	COG0823	Involved in the tonB-independent uptake of proteins
SRS16CHR_02569	COG2885	chlorophyll binding
SRS16CHR_02571	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SRS16CHR_02600	COG0071	Belongs to the small heat shock protein (HSP20) family
SRS16CHR_02603	COG0582	viral genome integration into host DNA
SRS16CHR_02604	COG0583	DNA-binding transcription factor activity
SRS16CHR_02609	COG2890	protein-(glutamine-N5) methyltransferase activity
SRS16CHR_02610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRS16CHR_02612	COG2171	N-acyltransferase activity
SRS16CHR_02613	COG0436	Aminotransferase
SRS16CHR_02614	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SRS16CHR_02614	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SRS16CHR_02615	COG1643	Atp-dependent helicase
SRS16CHR_02618	COG0436	Aminotransferase
SRS16CHR_02619	COG0583	DNA-binding transcription factor activity
SRS16CHR_02622	COG0795	lipopolysaccharide-transporting ATPase activity
SRS16CHR_02623	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SRS16CHR_02634	COG1982	Orn Lys Arg decarboxylase major
SRS16CHR_02635	COG1793	dna ligase
SRS16CHR_02636	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SRS16CHR_02637	COG4166	transmembrane transport
SRS16CHR_02638	COG4174	ABC transporter (Permease)
SRS16CHR_02639	COG4239	(ABC) transporter, permease
SRS16CHR_02640	COG4172	Belongs to the ABC transporter superfamily
SRS16CHR_02641	COG0477	Major facilitator Superfamily
SRS16CHR_02642	COG0779	Required for maturation of 30S ribosomal subunits
SRS16CHR_02643	COG0195	Participates in both transcription termination and antitermination
SRS16CHR_02643	COG2251	uridine kinase activity
SRS16CHR_02644	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SRS16CHR_02645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SRS16CHR_02646	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SRS16CHR_02654	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SRS16CHR_02655	COG2867	negative regulation of translational initiation
SRS16CHR_02659	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SRS16CHR_02659	COG0519	Catalyzes the synthesis of GMP from XMP
SRS16CHR_02660	COG3328	transposase activity
SRS16CHR_02666	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02668	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_02669	COG2186	Transcriptional regulator
SRS16CHR_02679	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_02680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SRS16CHR_02681	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SRS16CHR_02690	COG1619	proteins homologs of microcin C7 resistance protein MccF
SRS16CHR_02694	COG3158	transport of potassium into the cell
SRS16CHR_02695	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_02697	COG2188	Transcriptional regulator
SRS16CHR_02721	COG0084	hydrolase, TatD family'
SRS16CHR_02724	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SRS16CHR_02725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SRS16CHR_02733	COG2183	response to ionizing radiation
SRS16CHR_02736	COG0534	Mate efflux family protein
SRS16CHR_02752	COG0477	Major facilitator Superfamily
SRS16CHR_02753	COG2814	Major facilitator Superfamily
SRS16CHR_02754	COG2814	Major facilitator Superfamily
SRS16CHR_02761	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_02762	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SRS16CHR_02763	COG4638	Rieske (2fe-2S)
SRS16CHR_02766	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02769	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SRS16CHR_02769	COG3008	intermembrane lipid transfer
SRS16CHR_02770	COG2995	paraquat-inducible protein a
SRS16CHR_02771	COG2995	paraquat-inducible protein a
SRS16CHR_02773	COG5507	3-demethylubiquinone-9 3-methyltransferase
SRS16CHR_02776	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_02777	COG2130	NADP-dependent
SRS16CHR_02781	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_02782	COG0183	Belongs to the thiolase family
SRS16CHR_02783	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRS16CHR_02784	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_02784	COG1024	Enoyl-CoA hydratase
SRS16CHR_02785	COG1129	ABC transporter
SRS16CHR_02786	COG0411	ABC transporter
SRS16CHR_02791	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_02792	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SRS16CHR_02793	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SRS16CHR_02794	COG2917	probably involved in intracellular septation
SRS16CHR_02796	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SRS16CHR_02797	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SRS16CHR_02797	COG0047	phosphoribosylformylglycinamidine synthase activity
SRS16CHR_02798	COG0024	Methionine aminopeptidase
SRS16CHR_02799	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SRS16CHR_02800	COG0765	amino acid transport
SRS16CHR_02801	COG4597	amino acid ABC transporter
SRS16CHR_02802	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRS16CHR_02803	COG2259	Doxx family
SRS16CHR_02804	COG0242	peptide deformylase activity
SRS16CHR_02806	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SRS16CHR_02808	COG1196	nuclear chromosome segregation
SRS16CHR_02811	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SRS16CHR_02812	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SRS16CHR_02813	COG4208	sulfate ABC transporter
SRS16CHR_02815	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SRS16CHR_02817	COG0450	alkyl hydroperoxide reductase
SRS16CHR_02819	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SRS16CHR_02820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SRS16CHR_02823	COG1045	serine acetyltransferase
SRS16CHR_02825	COG0431	NADPH-dependent FMN reductase
SRS16CHR_02826	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SRS16CHR_02827	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SRS16CHR_02828	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16CHR_02828	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SRS16CHR_02830	COG1272	protein, Hemolysin III
SRS16CHR_02832	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SRS16CHR_02833	COG3383	formate dehydrogenase (NAD+) activity
SRS16CHR_02840	COG0175	sulfate reduction
SRS16CHR_02841	COG0175	sulfate reduction
SRS16CHR_02842	COG2895	sulfate adenylyltransferase (ATP) activity
SRS16CHR_02843	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SRS16CHR_02844	COG0492	ferredoxin-NADP+ reductase activity
SRS16CHR_02845	COG0671	phosphoesterase, PA-phosphatase related
SRS16CHR_02848	COG0351	phosphomethylpyrimidine kinase
SRS16CHR_02851	COG2022	thiamine diphosphate biosynthetic process
SRS16CHR_02853	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SRS16CHR_02853	COG2755	lipolytic protein G-D-S-L family
SRS16CHR_02859	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_02864	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_02866	COG2175	clavaminate synthase activity
SRS16CHR_02870	COG1024	Enoyl-CoA hydratase
SRS16CHR_02871	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_02872	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_02875	COG1024	Enoyl-CoA hydratase
SRS16CHR_02880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRS16CHR_02881	COG0642	Histidine kinase
SRS16CHR_02882	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_02883	COG1414	Transcriptional regulator
SRS16CHR_02884	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16CHR_02886	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SRS16CHR_02887	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SRS16CHR_02888	COG1414	Transcriptional regulator
SRS16CHR_02890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16CHR_02891	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16CHR_02892	COG1183	phosphatidylcholine synthase activity
SRS16CHR_02893	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SRS16CHR_02894	COG0440	acetolactate synthase activity
SRS16CHR_02895	COG0028	Belongs to the TPP enzyme family
SRS16CHR_02900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SRS16CHR_02902	COG0347	Belongs to the P(II) protein family
SRS16CHR_02906	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SRS16CHR_02912	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_02921	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SRS16CHR_02922	COG0746	molybdenum cofactor guanylyltransferase activity
SRS16CHR_02924	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SRS16CHR_02924	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SRS16CHR_02925	COG0328	RNA-DNA hybrid ribonuclease activity
SRS16CHR_02927	COG1388	LysM domain
SRS16CHR_02927	COG0741	lytic transglycosylase activity
SRS16CHR_02928	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_02930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SRS16CHR_02932	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SRS16CHR_02933	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SRS16CHR_02934	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SRS16CHR_02949	COG0493	'glutamate synthase
SRS16CHR_02949	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SRS16CHR_02950	COG1074	ATP-dependent DNA helicase activity
SRS16CHR_02953	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SRS16CHR_02954	COG0673	inositol 2-dehydrogenase activity
SRS16CHR_02955	COG0254	rRNA binding
SRS16CHR_02957	COG0534	Mate efflux family protein
SRS16CHR_02958	COG5002	protein histidine kinase activity
SRS16CHR_02961	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SRS16CHR_02962	COG0581	inorganic phosphate transmembrane transporter activity
SRS16CHR_02963	COG0573	inorganic phosphate transmembrane transporter activity
SRS16CHR_02964	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SRS16CHR_02965	COG0248	Ppx GppA phosphatase
SRS16CHR_02969	COG3634	alkyl hydroperoxide reductase activity
SRS16CHR_02970	COG0625	glutathione transferase activity
SRS16CHR_02976	COG1522	sequence-specific DNA binding
SRS16CHR_02979	COG4993	Dehydrogenase
SRS16CHR_02984	COG2188	Transcriptional regulator
SRS16CHR_02986	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_02989	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_02991	COG0183	Belongs to the thiolase family
SRS16CHR_02993	COG0439	Biotin carboxylase
SRS16CHR_02998	COG0156	8-amino-7-oxononanoate synthase activity
SRS16CHR_03000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SRS16CHR_03001	COG2124	cytochrome p450
SRS16CHR_03002	COG1309	transcriptional regulator
SRS16CHR_03003	COG1172	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_03005	COG0410	ABC transporter
SRS16CHR_03006	COG0411	ABC transporter
SRS16CHR_03008	COG1335	isochorismatase
SRS16CHR_03014	COG0583	DNA-binding transcription factor activity
SRS16CHR_03015	COG0277	FAD linked oxidase domain protein
SRS16CHR_03016	COG0277	FAD linked oxidase domain protein
SRS16CHR_03017	COG0277	FAD linked oxidase domain protein
SRS16CHR_03018	COG0247	lactate metabolic process
SRS16CHR_03020	COG3119	arylsulfatase activity
SRS16CHR_03027	COG2149	membrane
SRS16CHR_03030	COG0726	polysaccharide deacetylase
SRS16CHR_03031	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRS16CHR_03031	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SRS16CHR_03035	COG2076	Multidrug Resistance protein
SRS16CHR_03036	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SRS16CHR_03038	COG0667	Aldo Keto reductase
SRS16CHR_03041	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03044	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03050	COG1199	ATP-dependent helicase activity
SRS16CHR_03050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SRS16CHR_03054	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SRS16CHR_03055	COG0366	Alpha amylase catalytic
SRS16CHR_03056	COG0366	Alpha amylase catalytic
SRS16CHR_03059	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SRS16CHR_03060	COG1640	4-alpha-glucanotransferase
SRS16CHR_03062	COG1414	Transcriptional regulator
SRS16CHR_03064	COG0243	molybdopterin cofactor binding
SRS16CHR_03066	COG1024	Enoyl-CoA hydratase
SRS16CHR_03067	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_03068	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03069	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_03072	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_03074	COG1024	Enoyl-CoA hydratase
SRS16CHR_03081	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SRS16CHR_03084	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SRS16CHR_03085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_03086	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03088	COG1024	Enoyl-CoA hydratase
SRS16CHR_03092	COG0473	3-isopropylmalate dehydrogenase activity
SRS16CHR_03092	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16CHR_03100	COG1129	ABC transporter
SRS16CHR_03102	COG1053	succinate dehydrogenase
SRS16CHR_03103	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_03106	COG4221	oxidoreductase activity
SRS16CHR_03113	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03114	COG4689	acetoacetate decarboxylase
SRS16CHR_03121	COG2188	Transcriptional regulator
SRS16CHR_03123	COG2308	Evidence 4 Homologs of previously reported genes of
SRS16CHR_03127	COG1305	Transglutaminase-like
SRS16CHR_03129	COG1522	sequence-specific DNA binding
SRS16CHR_03131	COG1280	lysine exporter protein (LysE YggA)
SRS16CHR_03132	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SRS16CHR_03136	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_03138	COG1024	Enoyl-CoA hydratase
SRS16CHR_03139	COG1609	Transcriptional regulator
SRS16CHR_03141	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SRS16CHR_03143	COG1126	abc transporter atp-binding protein
SRS16CHR_03146	COG0765	amino acid transport
SRS16CHR_03153	COG1196	nuclear chromosome segregation
SRS16CHR_03153	COG0739	heme binding
SRS16CHR_03153	COG0741	lytic transglycosylase activity
SRS16CHR_03160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SRS16CHR_03161	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SRS16CHR_03162	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SRS16CHR_03165	COG2850	peptidyl-arginine hydroxylation
SRS16CHR_03166	COG1047	Peptidyl-prolyl cis-trans
SRS16CHR_03169	COG0583	DNA-binding transcription factor activity
SRS16CHR_03170	COG0756	dUTP diphosphatase activity
SRS16CHR_03172	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SRS16CHR_03173	COG0504	CTP synthase activity
SRS16CHR_03174	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SRS16CHR_03176	COG0148	phosphopyruvate hydratase activity
SRS16CHR_03177	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SRS16CHR_03180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SRS16CHR_03183	COG2833	Protein of unknown function (DUF455)
SRS16CHR_03186	COG4974	Belongs to the 'phage' integrase family
SRS16CHR_03187	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SRS16CHR_03191	COG0802	atpase or kinase
SRS16CHR_03192	COG0860	N-Acetylmuramoyl-L-alanine amidase
SRS16CHR_03195	COG0586	Pfam SNARE associated Golgi protein
SRS16CHR_03196	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03198	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SRS16CHR_03200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SRS16CHR_03201	COG4181	ATPase activity
SRS16CHR_03202	COG0583	DNA-binding transcription factor activity
SRS16CHR_03203	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03209	COG0583	DNA-binding transcription factor activity
SRS16CHR_03213	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SRS16CHR_03215	COG3795	YCII-related domain
SRS16CHR_03216	COG4941	Belongs to the sigma-70 factor family
SRS16CHR_03226	COG1566	PFAM secretion protein HlyD family protein
SRS16CHR_03227	COG1538	Outer membrane efflux protein
SRS16CHR_03228	COG1846	Transcriptional regulator
SRS16CHR_03229	COG1132	(ABC) transporter
SRS16CHR_03231	COG0494	nUDIX hydrolase
SRS16CHR_03233	COG1007	ATP synthesis coupled electron transport
SRS16CHR_03236	COG0713	ATP synthesis coupled electron transport
SRS16CHR_03238	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SRS16CHR_03239	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SRS16CHR_03240	COG1034	ATP synthesis coupled electron transport
SRS16CHR_03243	COG0649	NAD binding
SRS16CHR_03244	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SRS16CHR_03245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SRS16CHR_03246	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SRS16CHR_03249	COG0149	triose-phosphate isomerase activity
SRS16CHR_03250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SRS16CHR_03250	COG3321	synthase
SRS16CHR_03250	COG0604	alcohol dehydrogenase
SRS16CHR_03250	COG4221	oxidoreductase activity
SRS16CHR_03251	COG1185	polyribonucleotide nucleotidyltransferase activity
SRS16CHR_03252	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SRS16CHR_03253	COG0436	Aminotransferase
SRS16CHR_03254	COG0683	leucine binding
SRS16CHR_03257	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SRS16CHR_03258	COG3707	response regulator
SRS16CHR_03259	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SRS16CHR_03260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_03261	COG1116	anion transmembrane transporter activity
SRS16CHR_03263	COG2223	nitrite transmembrane transporter activity
SRS16CHR_03264	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SRS16CHR_03266	COG0243	molybdopterin cofactor binding
SRS16CHR_03267	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SRS16CHR_03270	COG2081	HI0933 family
SRS16CHR_03271	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SRS16CHR_03273	COG0494	nUDIX hydrolase
SRS16CHR_03274	COG0312	modulator of DNA gyrase
SRS16CHR_03275	COG3028	Belongs to the UPF0307 family
SRS16CHR_03276	COG0521	Mo-molybdopterin cofactor biosynthetic process
SRS16CHR_03277	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRS16CHR_03279	COG0765	amino acid transport
SRS16CHR_03280	COG0765	amino acid transport
SRS16CHR_03281	COG4221	oxidoreductase activity
SRS16CHR_03282	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SRS16CHR_03284	COG1984	allophanate hydrolase subunit 2
SRS16CHR_03285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SRS16CHR_03287	COG0511	ligase activity, forming carbon-carbon bonds
SRS16CHR_03289	COG0436	Aminotransferase
SRS16CHR_03290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16CHR_03292	COG0583	DNA-binding transcription factor activity
SRS16CHR_03297	COG1131	(ABC) transporter
SRS16CHR_03302	COG0436	Aminotransferase
SRS16CHR_03304	COG3265	gluconokinase activity
SRS16CHR_03305	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03306	COG1063	alcohol dehydrogenase
SRS16CHR_03307	COG1045	serine acetyltransferase
SRS16CHR_03310	COG1289	transmembrane transporter activity
SRS16CHR_03314	COG2375	cellular response to nickel ion
SRS16CHR_03319	COG2159	amidohydrolase
SRS16CHR_03323	COG0583	DNA-binding transcription factor activity
SRS16CHR_03324	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SRS16CHR_03327	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_03329	COG0583	DNA-binding transcription factor activity
SRS16CHR_03330	COG3119	arylsulfatase activity
SRS16CHR_03331	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03332	COG1968	undecaprenyl-diphosphatase activity
SRS16CHR_03334	COG3246	L-lysine catabolic process to acetate
SRS16CHR_03336	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_03337	COG2301	Belongs to the HpcH HpaI aldolase family
SRS16CHR_03341	COG1802	Transcriptional regulator
SRS16CHR_03343	COG1024	Enoyl-CoA hydratase
SRS16CHR_03346	COG1360	Flagellar Motor Protein
SRS16CHR_03352	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_03353	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_03358	COG2972	Histidine kinase
SRS16CHR_03361	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SRS16CHR_03366	COG0411	ABC transporter
SRS16CHR_03371	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SRS16CHR_03374	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03376	COG2918	glutathione biosynthetic process
SRS16CHR_03377	COG0400	carboxylic ester hydrolase activity
SRS16CHR_03379	COG0583	DNA-binding transcription factor activity
SRS16CHR_03388	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SRS16CHR_03394	COG2354	Protein conserved in bacteria
SRS16CHR_03397	COG4628	conserved protein (DUF2132)
SRS16CHR_03400	COG0564	pseudouridine synthase activity
SRS16CHR_03401	COG0589	response to stress
SRS16CHR_03404	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SRS16CHR_03405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SRS16CHR_03406	COG1252	NADH dehydrogenase
SRS16CHR_03408	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_03409	COG1764	response to oxidative stress
SRS16CHR_03412	COG0789	Transcriptional regulator
SRS16CHR_03414	COG3191	aminopeptidase activity
SRS16CHR_03416	COG0488	(ABC) transporter
SRS16CHR_03417	COG0513	Belongs to the DEAD box helicase family
SRS16CHR_03418	COG3842	ATPase activity
SRS16CHR_03420	COG1175	transmembrane transport
SRS16CHR_03422	COG2186	Transcriptional regulator
SRS16CHR_03423	COG3734	2-keto-3-deoxy-galactonokinase
SRS16CHR_03424	COG0800	Aldolase
SRS16CHR_03426	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SRS16CHR_03429	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SRS16CHR_03430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SRS16CHR_03444	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03447	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_03448	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_03449	COG2030	dehydratase
SRS16CHR_03455	COG1595	DNA-templated transcription, initiation
SRS16CHR_03457	COG3474	cytochrome
SRS16CHR_03458	COG0302	gtp cyclohydrolase
SRS16CHR_03459	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03464	COG0346	lactoylglutathione lyase activity
SRS16CHR_03467	COG0800	Aldolase
SRS16CHR_03472	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SRS16CHR_03473	COG0259	pyridoxamine-phosphate oxidase activity
SRS16CHR_03476	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SRS16CHR_03477	COG2301	Belongs to the HpcH HpaI aldolase family
SRS16CHR_03480	COG3618	amidohydrolase
SRS16CHR_03483	COG4772	TonB-dependent receptor
SRS16CHR_03485	COG2986	histidine ammonia-lyase
SRS16CHR_03486	COG1309	transcriptional regulator
SRS16CHR_03487	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SRS16CHR_03490	COG2207	Transcriptional regulator
SRS16CHR_03491	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_03493	COG2030	dehydratase
SRS16CHR_03498	COG0235	Class ii aldolase
SRS16CHR_03507	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SRS16CHR_03508	COG2863	cytochrome
SRS16CHR_03509	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SRS16CHR_03509	COG2010	Cytochrome c
SRS16CHR_03512	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SRS16CHR_03513	COG1309	transcriptional regulator
SRS16CHR_03516	COG5265	(ABC) transporter
SRS16CHR_03517	COG1132	(ABC) transporter
SRS16CHR_03518	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SRS16CHR_03520	COG2217	Heavy metal translocating P-type atpase
SRS16CHR_03521	COG0789	Transcriptional regulator
SRS16CHR_03528	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SRS16CHR_03529	COG2301	Belongs to the HpcH HpaI aldolase family
SRS16CHR_03533	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SRS16CHR_03536	COG1286	toxin biosynthetic process
SRS16CHR_03538	COG0285	dihydrofolate synthase activity
SRS16CHR_03539	COG1393	Belongs to the ArsC family
SRS16CHR_03541	COG3123	guanosine phosphorylase activity
SRS16CHR_03542	COG0137	argininosuccinate synthase activity
SRS16CHR_03543	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SRS16CHR_03544	COG1666	GTP binding
SRS16CHR_03547	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SRS16CHR_03548	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SRS16CHR_03549	COG0667	Aldo Keto reductase
SRS16CHR_03551	COG2205	protein histidine kinase activity
SRS16CHR_03551	COG3437	response regulator, receiver
SRS16CHR_03551	COG4999	Histidine kinase
SRS16CHR_03551	COG3850	Histidine kinase
SRS16CHR_03552	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SRS16CHR_03554	COG0784	Response regulator, receiver
SRS16CHR_03554	COG2205	protein histidine kinase activity
SRS16CHR_03555	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SRS16CHR_03556	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SRS16CHR_03557	COG0308	aminopeptidase N
SRS16CHR_03558	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SRS16CHR_03564	COG0326	Molecular chaperone. Has ATPase activity
SRS16CHR_03569	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SRS16CHR_03578	COG1403	HNH endonuclease
SRS16CHR_03586	COG0305	Participates in initiation and elongation during chromosome replication
SRS16CHR_03592	COG0582	viral genome integration into host DNA
SRS16CHR_03602	COG0582	viral genome integration into host DNA
SRS16CHR_03607	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03608	COG0583	DNA-binding transcription factor activity
SRS16CHR_03610	COG1301	dicarboxylic acid transport
SRS16CHR_03613	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_03614	COG2205	protein histidine kinase activity
SRS16CHR_03617	COG0840	transmembrane signaling receptor activity
SRS16CHR_03618	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_03620	COG2198	Histidine kinase
SRS16CHR_03620	COG0643	Histidine kinase
SRS16CHR_03621	COG0840	transmembrane signaling receptor activity
SRS16CHR_03622	COG0835	chemotaxis
SRS16CHR_03628	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SRS16CHR_03629	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SRS16CHR_03630	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SRS16CHR_03631	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_03633	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SRS16CHR_03634	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SRS16CHR_03636	COG0643	Histidine kinase
SRS16CHR_03636	COG2198	Histidine kinase
SRS16CHR_03645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SRS16CHR_03647	COG1677	Flagellar hook-basal body complex protein FliE
SRS16CHR_03648	COG1766	The M ring may be actively involved in energy transduction
SRS16CHR_03649	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SRS16CHR_03654	COG1580	Controls the rotational direction of flagella during chemotaxis
SRS16CHR_03655	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SRS16CHR_03658	COG1338	Plays a role in the flagellum-specific transport system
SRS16CHR_03659	COG1987	bacterial-type flagellum assembly
SRS16CHR_03663	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SRS16CHR_03669	COG1256	bacterial-type flagellum assembly
SRS16CHR_03670	COG0840	transmembrane signaling receptor activity
SRS16CHR_03672	COG0835	chemotaxis
SRS16CHR_03673	COG0840	transmembrane signaling receptor activity
SRS16CHR_03674	COG0835	chemotaxis
SRS16CHR_03675	COG3951	Flagellar rod assembly protein muramidase FlgJ
SRS16CHR_03675	COG1705	Flagellar rod assembly protein muramidase FlgJ
SRS16CHR_03676	COG1706	bacterial-type flagellum-dependent cell motility
SRS16CHR_03677	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SRS16CHR_03678	COG4786	Flagellar basal body rod
SRS16CHR_03681	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SRS16CHR_03682	COG1558	bacterial-type flagellum-dependent cell motility
SRS16CHR_03683	COG1815	bacterial-type flagellum-dependent cell motility
SRS16CHR_03687	COG0604	alcohol dehydrogenase
SRS16CHR_03688	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SRS16CHR_03693	COG0583	DNA-binding transcription factor activity
SRS16CHR_03699	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_03701	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_03703	COG3243	poly(R)-hydroxyalkanoic acid synthase
SRS16CHR_03705	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03709	COG3302	dmso reductase anchor subunit
SRS16CHR_03710	COG0437	4 iron, 4 sulfur cluster binding
SRS16CHR_03711	COG0243	molybdopterin cofactor binding
SRS16CHR_03712	COG0583	DNA-binding transcription factor activity
SRS16CHR_03717	COG1414	Transcriptional regulator
SRS16CHR_03722	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_03723	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_03727	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03728	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRS16CHR_03729	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03732	COG1414	Transcriptional regulator
SRS16CHR_03733	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SRS16CHR_03734	COG0477	Major facilitator Superfamily
SRS16CHR_03736	COG1609	Transcriptional regulator
SRS16CHR_03737	COG1082	Xylose isomerase domain protein TIM barrel
SRS16CHR_03742	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_03743	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SRS16CHR_03746	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_03747	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SRS16CHR_03749	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_03750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SRS16CHR_03751	COG4521	taurine ABC transporter
SRS16CHR_03752	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SRS16CHR_03756	COG0601	transmembrane transport
SRS16CHR_03757	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SRS16CHR_03758	COG0444	Belongs to the ABC transporter superfamily
SRS16CHR_03759	COG4608	Belongs to the ABC transporter superfamily
SRS16CHR_03763	COG0247	lactate metabolic process
SRS16CHR_03764	COG1592	Rubrerythrin
SRS16CHR_03766	COG2197	response regulator
SRS16CHR_03767	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRS16CHR_03768	COG1253	flavin adenine dinucleotide binding
SRS16CHR_03769	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SRS16CHR_03770	COG0513	Belongs to the DEAD box helicase family
SRS16CHR_03773	COG2321	neutral zinc metallopeptidase
SRS16CHR_03775	COG0717	Belongs to the dCTP deaminase family
SRS16CHR_03776	COG0402	S-adenosylhomocysteine deaminase activity
SRS16CHR_03780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SRS16CHR_03785	COG2252	PERMEase
SRS16CHR_03787	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SRS16CHR_03792	COG1850	ribulose-bisphosphate carboxylase activity
SRS16CHR_03794	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SRS16CHR_03795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SRS16CHR_03796	COG1609	Transcriptional regulator
SRS16CHR_03799	COG0583	DNA-binding transcription factor activity
SRS16CHR_03802	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_03804	COG2030	dehydratase
SRS16CHR_03806	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_03808	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_03810	COG1024	Enoyl-CoA hydratase
SRS16CHR_03811	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_03813	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16CHR_03815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SRS16CHR_03817	COG0667	Aldo Keto reductase
SRS16CHR_03819	COG0438	transferase activity, transferring glycosyl groups
SRS16CHR_03825	COG3608	succinylglutamate desuccinylase aspartoacylase
SRS16CHR_03825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SRS16CHR_03837	COG0667	Aldo Keto reductase
SRS16CHR_03843	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_03844	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16CHR_03851	COG2084	Dehydrogenase
SRS16CHR_03852	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_03853	COG0642	Histidine kinase
SRS16CHR_03856	COG0671	phosphoesterase, PA-phosphatase related
SRS16CHR_03857	COG0463	Glycosyl transferase, family 2
SRS16CHR_03858	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SRS16CHR_03860	COG1116	anion transmembrane transporter activity
SRS16CHR_03861	COG0390	transport system, permease component
SRS16CHR_03863	COG1609	Transcriptional regulator
SRS16CHR_03867	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16CHR_03869	COG1950	PFAM Membrane protein of
SRS16CHR_03870	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_03871	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SRS16CHR_03872	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16CHR_03875	COG1122	ATPase activity
SRS16CHR_03879	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_03881	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SRS16CHR_03882	COG2151	metal-sulfur cluster biosynthetic enzyme
SRS16CHR_03883	COG3396	Phenylacetate-CoA oxygenase
SRS16CHR_03884	COG3460	Phenylacetate-CoA oxygenase
SRS16CHR_03885	COG3396	Phenylacetate-CoA oxygenase
SRS16CHR_03887	COG2050	protein possibly involved in aromatic compounds catabolism
SRS16CHR_03888	COG1024	Enoyl-CoA hydratase
SRS16CHR_03890	COG1309	transcriptional regulator
SRS16CHR_03892	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SRS16CHR_03900	COG0392	lysyltransferase activity
SRS16CHR_03901	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SRS16CHR_03902	COG0142	geranyltranstransferase activity
SRS16CHR_03903	COG1722	exodeoxyribonuclease VII activity
SRS16CHR_03912	COG3360	Dodecin
SRS16CHR_03921	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SRS16CHR_03923	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_03924	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SRS16CHR_03928	COG1176	ABC-type spermidine putrescine transport system, permease component I
SRS16CHR_03929	COG3842	ATPase activity
SRS16CHR_03932	COG0210	DNA helicase
SRS16CHR_03933	COG0516	GMP reductase activity
SRS16CHR_03936	COG0300	oxidoreductase activity
SRS16CHR_03938	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRS16CHR_03940	COG3851	Histidine kinase
SRS16CHR_03948	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SRS16CHR_03949	COG0028	Belongs to the TPP enzyme family
SRS16CHR_03954	COG0513	Belongs to the DEAD box helicase family
SRS16CHR_03955	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SRS16CHR_03956	COG0501	Belongs to the peptidase M48B family
SRS16CHR_03957	COG2154	pterin-4-alpha-carbinolamine dehydratase
SRS16CHR_03958	COG1162	GTPase activity
SRS16CHR_03959	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SRS16CHR_03960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SRS16CHR_03962	COG0335	large ribosomal subunit rRNA binding
SRS16CHR_03963	COG0336	Belongs to the RNA methyltransferase TrmD family
SRS16CHR_03964	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SRS16CHR_03965	COG0228	four-way junction DNA binding
SRS16CHR_03968	COG0306	phosphate transporter
SRS16CHR_03969	COG1392	Phosphate transport regulator
SRS16CHR_03971	COG0617	tRNA 3'-terminal CCA addition
SRS16CHR_03972	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SRS16CHR_03973	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SRS16CHR_03976	COG1917	Cupin 2, conserved barrel domain protein
SRS16CHR_03976	COG4977	sequence-specific DNA binding
SRS16CHR_03977	COG1289	transmembrane transporter activity
SRS16CHR_03980	COG0728	peptidoglycan biosynthetic process
SRS16CHR_03981	COG0268	Binds directly to 16S ribosomal RNA
SRS16CHR_03983	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SRS16CHR_03984	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SRS16CHR_03985	COG3550	peptidyl-serine autophosphorylation
SRS16CHR_03986	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SRS16CHR_03988	COG3483	tryptophan 2,3-dioxygenase activity
SRS16CHR_03990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16CHR_03992	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SRS16CHR_03992	COG1918	ferrous iron import across plasma membrane
SRS16CHR_03995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SRS16CHR_03998	COG1049	propionate catabolic process, 2-methylcitrate cycle
SRS16CHR_04001	COG4106	trans-aconitate 2-methyltransferase activity
SRS16CHR_04002	COG0039	L-malate dehydrogenase activity
SRS16CHR_04003	COG2188	Transcriptional regulator
SRS16CHR_04006	COG1053	succinate dehydrogenase
SRS16CHR_04007	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SRS16CHR_04008	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SRS16CHR_04009	COG0372	Belongs to the citrate synthase family
SRS16CHR_04011	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SRS16CHR_04012	COG0066	3-isopropylmalate dehydratase activity
SRS16CHR_04013	COG0473	3-isopropylmalate dehydrogenase activity
SRS16CHR_04014	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SRS16CHR_04016	COG0101	tRNA pseudouridine synthase activity
SRS16CHR_04017	COG0135	phosphoribosylanthranilate isomerase activity
SRS16CHR_04018	COG0133	tryptophan synthase activity
SRS16CHR_04019	COG0159	tryptophan synthase activity
SRS16CHR_04020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SRS16CHR_04021	COG0762	integral membrane protein
SRS16CHR_04023	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SRS16CHR_04024	COG0443	Heat shock 70 kDa protein
SRS16CHR_04025	COG1451	nucleotide metabolic process
SRS16CHR_04026	COG1472	Belongs to the glycosyl hydrolase 3 family
SRS16CHR_04027	COG0736	holo-[acyl-carrier-protein] synthase activity
SRS16CHR_04028	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SRS16CHR_04029	COG1381	Involved in DNA repair and RecF pathway recombination
SRS16CHR_04030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SRS16CHR_04031	COG0571	ribonuclease III activity
SRS16CHR_04033	COG0681	Belongs to the peptidase S26 family
SRS16CHR_04034	COG0481	GTPase activity
SRS16CHR_04035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRS16CHR_04040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SRS16CHR_04041	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SRS16CHR_04042	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04044	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SRS16CHR_04045	COG0416	fatty acid biosynthetic process
SRS16CHR_04046	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SRS16CHR_04047	COG1399	metal-binding, possibly nucleic acid-binding protein
SRS16CHR_04048	COG0424	maF-like protein
SRS16CHR_04049	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SRS16CHR_04050	COG2223	nitrite transmembrane transporter activity
SRS16CHR_04053	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SRS16CHR_04055	COG1530	ribonuclease E activity
SRS16CHR_04058	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRS16CHR_04062	COG0297	glycogen (starch) synthase activity
SRS16CHR_04063	COG0489	protein tyrosine kinase activity
SRS16CHR_04063	COG3206	protein involved in exopolysaccharide biosynthesis
SRS16CHR_04064	COG3206	protein involved in exopolysaccharide biosynthesis
SRS16CHR_04064	COG0489	protein tyrosine kinase activity
SRS16CHR_04071	COG0181	hydroxymethylbilane synthase activity
SRS16CHR_04072	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SRS16CHR_04074	COG3459	Glycosyltransferase 36 associated
SRS16CHR_04077	COG3275	phosphorelay sensor kinase activity
SRS16CHR_04078	COG0165	Argininosuccinate lyase
SRS16CHR_04086	COG0438	transferase activity, transferring glycosyl groups
SRS16CHR_04089	COG2197	response regulator
SRS16CHR_04094	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SRS16CHR_04096	COG0583	DNA-binding transcription factor activity
SRS16CHR_04097	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16CHR_04099	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SRS16CHR_04101	COG0477	Major facilitator Superfamily
SRS16CHR_04103	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SRS16CHR_04109	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SRS16CHR_04109	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SRS16CHR_04112	COG3022	response to hydroperoxide
SRS16CHR_04113	COG0525	valine-tRNA ligase activity
SRS16CHR_04116	COG0425	Belongs to the sulfur carrier protein TusA family
SRS16CHR_04117	COG2816	NAD+ diphosphatase activity
SRS16CHR_04121	COG5001	Diguanylate cyclase
SRS16CHR_04121	COG4251	negative regulation of phosphorylation
SRS16CHR_04121	COG3706	GGDEF domain
SRS16CHR_04121	COG2203	Gaf domain
SRS16CHR_04123	COG5002	protein histidine kinase activity
SRS16CHR_04123	COG3447	MASE1 domain protein
SRS16CHR_04123	COG5001	Diguanylate cyclase
SRS16CHR_04124	COG2204	response regulator
SRS16CHR_04131	COG1222	aaa ATPase
SRS16CHR_04151	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_04152	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SRS16CHR_04153	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SRS16CHR_04154	COG1674	ftsk spoiiie
SRS16CHR_04156	COG0492	ferredoxin-NADP+ reductase activity
SRS16CHR_04157	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SRS16CHR_04158	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SRS16CHR_04160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SRS16CHR_04160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SRS16CHR_04162	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SRS16CHR_04163	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04170	COG0196	riboflavin kinase activity
SRS16CHR_04172	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SRS16CHR_04173	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SRS16CHR_04174	COG1283	sodium-dependent phosphate transmembrane transporter activity
SRS16CHR_04176	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04178	COG0405	Gamma-glutamyltransferase
SRS16CHR_04179	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04180	COG0583	DNA-binding transcription factor activity
SRS16CHR_04183	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SRS16CHR_04184	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SRS16CHR_04187	COG0084	hydrolase, TatD family'
SRS16CHR_04188	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRS16CHR_04189	COG0714	Associated with various cellular activities
SRS16CHR_04191	COG2304	oxidoreductase activity
SRS16CHR_04193	COG1959	2 iron, 2 sulfur cluster binding
SRS16CHR_04196	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SRS16CHR_04197	COG0038	chloride channel
SRS16CHR_04200	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SRS16CHR_04201	COG1737	Transcriptional regulator
SRS16CHR_04206	COG0601	transmembrane transport
SRS16CHR_04208	COG0251	oxidation-reduction process
SRS16CHR_04209	COG1201	RNA secondary structure unwinding
SRS16CHR_04211	COG1573	uracil-dna glycosylase
SRS16CHR_04212	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SRS16CHR_04214	COG3842	ATPase activity
SRS16CHR_04218	COG0045	succinate-CoA ligase (ADP-forming) activity
SRS16CHR_04219	COG1024	Enoyl-CoA hydratase
SRS16CHR_04220	COG1024	Enoyl-CoA hydratase
SRS16CHR_04222	COG1024	Enoyl-CoA hydratase
SRS16CHR_04223	COG2951	lytic endotransglycosylase activity
SRS16CHR_04224	COG1136	(ABC) transporter
SRS16CHR_04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
SRS16CHR_04227	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SRS16CHR_04230	COG0642	Histidine kinase
SRS16CHR_04235	COG0784	Response regulator, receiver
SRS16CHR_04235	COG2198	Histidine kinase
SRS16CHR_04235	COG5002	protein histidine kinase activity
SRS16CHR_04236	COG0831	urea catabolic process
SRS16CHR_04238	COG0832	Belongs to the urease beta subunit family
SRS16CHR_04239	COG0804	urea catabolic process
SRS16CHR_04241	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SRS16CHR_04242	COG0830	nickel cation binding
SRS16CHR_04243	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SRS16CHR_04249	COG1024	Enoyl-CoA hydratase
SRS16CHR_04251	COG1414	Transcriptional regulator
SRS16CHR_04252	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04253	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SRS16CHR_04258	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16CHR_04265	COG0402	S-adenosylhomocysteine deaminase activity
SRS16CHR_04266	COG0583	DNA-binding transcription factor activity
SRS16CHR_04267	COG1335	isochorismatase
SRS16CHR_04268	COG1942	4-Oxalocrotonate Tautomerase
SRS16CHR_04273	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SRS16CHR_04274	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_04278	COG0523	cobalamin synthesis protein
SRS16CHR_04281	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16CHR_04283	COG1741	Belongs to the pirin family
SRS16CHR_04286	COG0583	DNA-binding transcription factor activity
SRS16CHR_04287	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04290	COG2020	methyltransferase activity
SRS16CHR_04303	COG2826	transposase and inactivated derivatives, IS30 family
SRS16CHR_04306	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SRS16CHR_04317	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SRS16CHR_04318	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SRS16CHR_04319	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SRS16CHR_04321	COG0515	serine threonine protein kinase
SRS16CHR_04321	COG2815	serine threonine protein kinase
SRS16CHR_04322	COG1561	YicC-like family, N-terminal region
SRS16CHR_04323	COG0194	GDP metabolic process
SRS16CHR_04324	COG1758	RNA polymerase activity
SRS16CHR_04325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SRS16CHR_04328	COG1285	pathogenesis
SRS16CHR_04335	COG2860	membrane
SRS16CHR_04337	COG1420	regulation of RNA biosynthetic process
SRS16CHR_04338	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SRS16CHR_04339	COG0497	DNA recombination
SRS16CHR_04340	COG1660	Displays ATPase and GTPase activities
SRS16CHR_04341	COG1194	a g-specific adenine glycosylase
SRS16CHR_04342	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SRS16CHR_04343	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SRS16CHR_04346	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SRS16CHR_04348	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SRS16CHR_04349	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SRS16CHR_04350	COG0193	aminoacyl-tRNA hydrolase activity
SRS16CHR_04352	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SRS16CHR_04354	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SRS16CHR_04355	COG0444	Belongs to the ABC transporter superfamily
SRS16CHR_04356	COG4608	Belongs to the ABC transporter superfamily
SRS16CHR_04357	COG0747	negative chemotaxis
SRS16CHR_04358	COG0154	amidase activity
SRS16CHR_04360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SRS16CHR_04361	COG0673	inositol 2-dehydrogenase activity
SRS16CHR_04363	COG0583	DNA-binding transcription factor activity
SRS16CHR_04366	COG1473	amidohydrolase
SRS16CHR_04367	COG0747	negative chemotaxis
SRS16CHR_04368	COG0601	transmembrane transport
SRS16CHR_04370	COG0444	Belongs to the ABC transporter superfamily
SRS16CHR_04372	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SRS16CHR_04378	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SRS16CHR_04380	COG0406	alpha-ribazole phosphatase activity
SRS16CHR_04381	COG2267	carboxylic ester hydrolase activity
SRS16CHR_04382	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SRS16CHR_04383	COG1984	allophanate hydrolase subunit 2
SRS16CHR_04384	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SRS16CHR_04385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SRS16CHR_04386	COG0742	ribosomal rna small subunit methyltransferase
SRS16CHR_04387	COG0612	Peptidase, M16
SRS16CHR_04388	COG0612	Peptidase, M16
SRS16CHR_04392	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SRS16CHR_04393	COG1999	signal sequence binding
SRS16CHR_04394	COG0109	protoheme IX farnesyltransferase activity
SRS16CHR_04400	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SRS16CHR_04402	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SRS16CHR_04403	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SRS16CHR_04405	COG2226	methyltransferase
SRS16CHR_04406	COG1040	competence protein
SRS16CHR_04407	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SRS16CHR_04411	COG2249	NAD(P)H dehydrogenase (quinone) activity
SRS16CHR_04415	COG1733	regulation of RNA biosynthetic process
SRS16CHR_04417	COG1024	Enoyl-CoA hydratase
SRS16CHR_04425	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04437	COG3485	protocatechuate 3,4-dioxygenase
SRS16CHR_04442	COG0183	Belongs to the thiolase family
SRS16CHR_04443	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SRS16CHR_04445	COG1414	Transcriptional regulator
SRS16CHR_04451	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SRS16CHR_04452	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SRS16CHR_04460	COG1137	ATPase activity
SRS16CHR_04462	COG1012	belongs to the aldehyde dehydrogenase family
SRS16CHR_04465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRS16CHR_04468	COG0583	DNA-binding transcription factor activity
SRS16CHR_04471	COG0583	DNA-binding transcription factor activity
SRS16CHR_04472	COG3485	protocatechuate 3,4-dioxygenase
SRS16CHR_04473	COG3485	protocatechuate 3,4-dioxygenase
SRS16CHR_04475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SRS16CHR_04485	COG0583	DNA-binding transcription factor activity
SRS16CHR_04486	COG1473	amidohydrolase
SRS16CHR_04489	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04491	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04492	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04500	COG0477	Major facilitator Superfamily
SRS16CHR_04503	COG0540	Belongs to the ATCase OTCase family
SRS16CHR_04504	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SRS16CHR_04505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SRS16CHR_04506	COG1678	Uncharacterized ACR, COG1678
SRS16CHR_04507	COG0415	Belongs to the DNA photolyase family
SRS16CHR_04508	COG2198	Histidine kinase
SRS16CHR_04508	COG0643	Histidine kinase
SRS16CHR_04509	COG0840	transmembrane signaling receptor activity
SRS16CHR_04514	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SRS16CHR_04516	COG0138	bifunctional purine biosynthesis protein purh
SRS16CHR_04518	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SRS16CHR_04519	COG1238	metal cluster binding
SRS16CHR_04522	COG0012	GTP binding
SRS16CHR_04523	COG0633	Ferredoxin
SRS16CHR_04523	COG3217	Mosc domain protein beta barrel domain protein
SRS16CHR_04524	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16CHR_04527	COG1024	Enoyl-CoA hydratase
SRS16CHR_04532	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04533	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04534	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04538	COG1024	Enoyl-CoA hydratase
SRS16CHR_04541	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04542	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04543	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_04545	COG2084	Dehydrogenase
SRS16CHR_04552	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04553	COG1024	Enoyl-CoA hydratase
SRS16CHR_04554	COG0446	pyridine nucleotide-disulphide oxidoreductase
SRS16CHR_04554	COG1902	pentaerythritol trinitrate reductase activity
SRS16CHR_04555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SRS16CHR_04556	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04558	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04559	COG0583	DNA-binding transcription factor activity
SRS16CHR_04560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04561	COG1024	Enoyl-CoA hydratase
SRS16CHR_04562	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04563	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04568	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRS16CHR_04572	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_04574	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04581	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SRS16CHR_04583	COG2255	four-way junction helicase activity
SRS16CHR_04585	COG0632	four-way junction helicase activity
SRS16CHR_04586	COG1702	phosphate starvation-inducible protein PhoH
SRS16CHR_04587	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SRS16CHR_04588	COG1490	D-aminoacyl-tRNA deacylase activity
SRS16CHR_04589	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SRS16CHR_04590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SRS16CHR_04591	COG0739	heme binding
SRS16CHR_04592	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SRS16CHR_04593	COG0477	Major facilitator Superfamily
SRS16CHR_04594	COG0316	Belongs to the HesB IscA family
SRS16CHR_04595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SRS16CHR_04596	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SRS16CHR_04597	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SRS16CHR_04598	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SRS16CHR_04601	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SRS16CHR_04602	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SRS16CHR_04606	COG1309	transcriptional regulator
SRS16CHR_04611	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_04616	COG1309	transcriptional regulator
SRS16CHR_04618	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SRS16CHR_04620	COG0477	Major facilitator Superfamily
SRS16CHR_04625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRS16CHR_04628	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SRS16CHR_04630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRS16CHR_04631	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_04632	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SRS16CHR_04636	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SRS16CHR_04640	COG3012	SEC-C Motif Domain Protein
SRS16CHR_04641	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04642	COG0183	Belongs to the thiolase family
SRS16CHR_04643	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
SRS16CHR_04644	COG0288	reversible hydration of carbon dioxide
SRS16CHR_04645	COG0789	Transcriptional regulator
SRS16CHR_04648	COG0564	pseudouridine synthase activity
SRS16CHR_04650	COG2205	protein histidine kinase activity
SRS16CHR_04654	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SRS16CHR_04655	COG0751	glycine-tRNA ligase activity
SRS16CHR_04656	COG0752	glycyl-tRNA synthetase alpha subunit
SRS16CHR_04658	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SRS16CHR_04659	COG4535	Mg2 and Co2 transporter CorC
SRS16CHR_04661	COG1522	sequence-specific DNA binding
SRS16CHR_04664	COG3186	Phenylalanine-4-hydroxylase
SRS16CHR_04665	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_04673	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_04674	COG2188	Transcriptional regulator
SRS16CHR_04675	COG0697	spore germination
SRS16CHR_04676	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SRS16CHR_04678	COG0384	phenazine biosynthesis protein PhzF
SRS16CHR_04680	COG1280	lysine exporter protein (LysE YggA)
SRS16CHR_04681	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SRS16CHR_04682	COG3468	outer membrane autotransporter barrel domain protein
SRS16CHR_04682	COG3468	outer membrane autotransporter barrel domain protein
SRS16CHR_04687	COG1881	PFAM PEBP family protein
SRS16CHR_04690	COG0402	S-adenosylhomocysteine deaminase activity
SRS16CHR_04692	COG1609	Transcriptional regulator
SRS16CHR_04694	COG4232	protein-disulfide reductase activity
SRS16CHR_04695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SRS16CHR_04696	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SRS16CHR_04697	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SRS16CHR_04700	COG0679	Auxin Efflux Carrier
SRS16CHR_04701	COG0210	DNA helicase
SRS16CHR_04704	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SRS16CHR_04706	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SRS16CHR_04710	COG0402	S-adenosylhomocysteine deaminase activity
SRS16CHR_04711	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04714	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRS16CHR_04715	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04716	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04719	COG0583	DNA-binding transcription factor activity
SRS16CHR_04720	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04724	COG3246	L-lysine catabolic process to acetate
SRS16CHR_04725	COG2175	clavaminate synthase activity
SRS16CHR_04727	COG2175	clavaminate synthase activity
SRS16CHR_04732	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04733	COG3246	L-lysine catabolic process to acetate
SRS16CHR_04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_04736	COG1116	anion transmembrane transporter activity
SRS16CHR_04740	COG0439	Biotin carboxylase
SRS16CHR_04742	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04743	COG2186	Transcriptional regulator
SRS16CHR_04744	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04745	COG0511	ligase activity, forming carbon-carbon bonds
SRS16CHR_04746	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_04747	COG0431	NADPH-dependent FMN reductase
SRS16CHR_04749	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04752	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_04754	COG1024	Enoyl-CoA hydratase
SRS16CHR_04756	COG0583	DNA-binding transcription factor activity
SRS16CHR_04757	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SRS16CHR_04758	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_04759	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SRS16CHR_04760	COG0426	domain, Protein
SRS16CHR_04760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SRS16CHR_04761	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04763	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SRS16CHR_04765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16CHR_04775	COG3971	2-oxopent-4-enoate hydratase activity
SRS16CHR_04778	COG0583	DNA-binding transcription factor activity
SRS16CHR_04781	COG1609	Transcriptional regulator
SRS16CHR_04789	COG0148	phosphopyruvate hydratase activity
SRS16CHR_04794	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRS16CHR_04796	COG0582	viral genome integration into host DNA
SRS16CHR_04803	COG4372	Transposase
SRS16CHR_04804	COG3436	PFAM IS66 Orf2 family protein
SRS16CHR_04810	COG2814	Major facilitator Superfamily
SRS16CHR_04811	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SRS16CHR_04812	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SRS16CHR_04816	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_04817	COG1053	succinate dehydrogenase
SRS16CHR_04825	COG1172	Belongs to the binding-protein-dependent transport system permease family
SRS16CHR_04826	COG1129	ABC transporter
SRS16CHR_04830	COG4584	PFAM Integrase catalytic
SRS16CHR_04833	COG5377	YqaJ viral recombinase family
SRS16CHR_04836	COG2003	Belongs to the UPF0758 family
SRS16CHR_04838	COG1204	response to ionizing radiation
SRS16CHR_04847	COG0347	Belongs to the P(II) protein family
SRS16CHR_04861	COG0789	Transcriptional regulator
SRS16CHR_04863	COG0672	)-iron permease
SRS16CHR_04865	COG2205	protein histidine kinase activity
SRS16CHR_04865	COG0784	Response regulator, receiver
SRS16CHR_04866	COG0789	Transcriptional regulator
SRS16CHR_04869	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SRS16CHR_04870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SRS16CHR_04880	COG0789	Transcriptional regulator
SRS16CHR_04883	COG0640	Transcriptional regulator
SRS16CHR_04885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SRS16CHR_04885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SRS16CHR_04886	COG2814	Major facilitator Superfamily
SRS16CHR_04892	COG1695	Transcriptional regulator
SRS16CHR_04895	COG2948	multi-organism process
SRS16CHR_04901	COG3451	type IV secretory pathway VirB4
SRS16CHR_04904	COG4962	Type ii secretion system protein e
SRS16CHR_04907	COG0583	DNA-binding transcription factor activity
SRS16CHR_04908	COG1126	abc transporter atp-binding protein
SRS16CHR_04910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRS16CHR_04919	COG1192	Involved in chromosome partitioning
SRS16CHR_04924	COG1396	sequence-specific DNA binding
SRS16CHR_04926	COG5489	Protein of unknown function (DUF736)
SRS16CHR_04930	COG2003	Belongs to the UPF0758 family
SRS16CHR_04937	COG4804	nuclease activity
SRS16CHR_04938	COG0582	viral genome integration into host DNA
SRS16CHR_04940	COG2204	response regulator
SRS16CHR_04941	COG5000	phosphorelay sensor kinase activity
SRS16CHR_04945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SRS16CHR_04946	COG0085	RNA polymerase activity
SRS16CHR_04947	COG0222	ribosome binding
SRS16CHR_04948	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SRS16CHR_04949	COG0081	regulation of translation
SRS16CHR_04950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SRS16CHR_04952	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SRS16CHR_04954	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SRS16CHR_04958	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SRS16CHR_04959	COG0134	indole-3-glycerol-phosphate synthase activity
SRS16CHR_04960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SRS16CHR_04961	COG1280	lysine exporter protein (LysE YggA)
SRS16CHR_04967	COG0546	phosphoglycolate phosphatase activity
SRS16CHR_04970	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_04981	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SRS16CHR_04982	COG0436	Aminotransferase
SRS16CHR_04983	COG0251	oxidation-reduction process
SRS16CHR_04984	COG0384	phenazine biosynthesis protein PhzF
SRS16CHR_04998	COG3501	Rhs element vgr protein
SRS16CHR_05009	COG0515	serine threonine protein kinase
SRS16CHR_05016	COG0154	amidase activity
SRS16CHR_05018	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SRS16CHR_05021	COG2205	protein histidine kinase activity
SRS16CHR_05037	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SRS16CHR_05045	COG3265	gluconokinase activity
SRS16CHR_05050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SRS16CHR_05050	COG0674	pyruvate-flavodoxin oxidoreductase activity
SRS16CHR_05053	COG2967	ApaG domain
SRS16CHR_05055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SRS16CHR_05060	COG0583	DNA-binding transcription factor activity
SRS16CHR_05063	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SRS16CHR_05064	COG2198	Histidine kinase
SRS16CHR_05064	COG2205	protein histidine kinase activity
SRS16CHR_05064	COG0784	Response regulator, receiver
SRS16CHR_05065	COG2197	response regulator
SRS16CHR_05068	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_05071	COG2226	methyltransferase
SRS16CHR_05072	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SRS16CHR_05073	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16CHR_05074	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SRS16CHR_05079	COG0583	DNA-binding transcription factor activity
SRS16CHR_05080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SRS16CHR_05084	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_05088	COG0653	protein targeting
SRS16CHR_05089	COG0069	glutamate synthase activity
SRS16CHR_05091	COG0783	Belongs to the Dps family
SRS16CHR_05092	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SRS16CHR_05095	COG2197	response regulator
SRS16CHR_05096	COG4585	Histidine kinase
SRS16CHR_05098	COG2205	protein histidine kinase activity
SRS16CHR_05098	COG0784	Response regulator, receiver
SRS16CHR_05099	COG3038	cytochrome b561
SRS16CHR_05102	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SRS16CHR_05103	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SRS16CHR_05104	COG1137	ATPase activity
SRS16CHR_05105	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SRS16CHR_05106	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SRS16CHR_05108	COG0018	arginyl-trna synthetase
SRS16CHR_05114	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_05115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16CHR_05116	COG1414	Transcriptional regulator
SRS16CHR_05117	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SRS16CHR_05120	COG0784	Response regulator, receiver
SRS16CHR_05120	COG2205	protein histidine kinase activity
SRS16CHR_05125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SRS16CHR_05126	COG0583	DNA-binding transcription factor activity
SRS16CHR_05128	COG0205	6-phosphofructokinase activity
SRS16CHR_05131	COG2814	Major facilitator Superfamily
SRS16CHR_05132	COG0121	glutamine amidotransferase
SRS16CHR_05133	COG0189	ligase activity
SRS16CHR_05134	COG3135	benzoate transporter
SRS16CHR_05135	COG3158	transport of potassium into the cell
SRS16CHR_05137	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SRS16CHR_05139	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
SRS16CHR_05140	COG0495	leucyl-tRNA aminoacylation
SRS16CHR_05141	COG1523	belongs to the glycosyl hydrolase 13 family
SRS16CHR_05142	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SRS16CHR_05143	COG0297	glycogen (starch) synthase activity
SRS16CHR_05144	COG0058	SHG alpha-glucan phosphorylase activity
SRS16CHR_05146	COG1921	L-seryl-tRNASec selenium transferase activity
SRS16CHR_05153	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_05155	COG1305	Transglutaminase-like
SRS16CHR_05156	COG0583	DNA-binding transcription factor activity
SRS16CHR_05159	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SRS16CHR_05160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SRS16CHR_05161	COG0735	belongs to the Fur family
SRS16CHR_05162	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SRS16CHR_05164	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SRS16CHR_05165	COG0210	DNA helicase
SRS16CHR_05166	COG0598	Magnesium transport protein CorA
SRS16CHR_05172	COG4638	Rieske (2fe-2S)
SRS16CHR_05173	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRS16CHR_05175	COG0028	Belongs to the TPP enzyme family
SRS16CHR_05177	COG0747	negative chemotaxis
SRS16CHR_05178	COG4608	Belongs to the ABC transporter superfamily
SRS16CHR_05179	COG0444	Belongs to the ABC transporter superfamily
SRS16CHR_05180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SRS16CHR_05181	COG0601	transmembrane transport
SRS16CHR_05182	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_05186	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_05189	COG0482	sulfurtransferase activity
SRS16CHR_05190	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_05192	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SRS16CHR_05194	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_05195	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SRS16CHR_05196	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRS16CHR_05197	COG2721	sulfolactate sulfo-lyase activity
SRS16CHR_05198	COG2721	sulfolactate sulfo-lyase activity
SRS16CHR_05199	COG2188	Transcriptional regulator
SRS16CHR_05202	COG0629	single-stranded DNA binding
SRS16CHR_05210	COG0277	FAD linked oxidase domain protein
SRS16CHR_05211	COG0745	RESPONSE REGULATOR receiver
SRS16CHR_05213	COG3852	Histidine kinase
SRS16CHR_05215	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_05218	COG1902	pentaerythritol trinitrate reductase activity
SRS16CHR_05228	COG0436	Aminotransferase
SRS16CHR_05230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16CHR_05230	COG0473	3-isopropylmalate dehydrogenase activity
SRS16CHR_05233	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_05234	COG0583	DNA-binding transcription factor activity
SRS16CHR_05237	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16CHR_05239	COG0596	Alpha beta hydrolase
SRS16CHR_05241	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16CHR_05243	COG0583	DNA-binding transcription factor activity
SRS16CHR_05247	COG0583	DNA-binding transcription factor activity
SRS16CHR_05251	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_05253	COG0778	Nitroreductase
SRS16CHR_05254	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SRS16CHR_05255	COG1946	Acyl-CoA thioesterase
SRS16CHR_05256	COG0446	pyridine nucleotide-disulphide oxidoreductase
SRS16CHR_05257	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16CHR_05258	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16CHR_05261	COG0583	DNA-binding transcription factor activity
SRS16CHR_05263	COG0179	Fumarylacetoacetate (FAA) hydrolase
SRS16CHR_05264	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SRS16CHR_05271	COG0284	orotidine-5'-phosphate decarboxylase activity
SRS16CHR_05275	COG2027	D-alanyl-D-alanine carboxypeptidase
SRS16CHR_05278	COG0009	L-threonylcarbamoyladenylate synthase
SRS16CHR_05279	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SRS16CHR_05280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SRS16CHR_05281	COG3118	belongs to the thioredoxin family
SRS16CHR_05283	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SRS16CHR_05286	COG0469	pyruvate kinase activity
SRS16CHR_05287	COG0126	phosphoglycerate kinase activity
SRS16CHR_05290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SRS16CHR_05292	COG0242	peptide deformylase activity
SRS16CHR_05294	COG0758	DNA mediated transformation
SRS16CHR_05295	COG2922	Belongs to the Smg family
SRS16CHR_05297	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SRS16CHR_05298	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SRS16CHR_05299	COG1862	Preprotein translocase
SRS16CHR_05300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SRS16CHR_05302	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRS16CHR_05307	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16CHR_05309	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_05311	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRS16CHR_05314	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_05314	COG1024	Enoyl-CoA hydratase
SRS16CHR_05316	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16CHR_05319	COG1024	Enoyl-CoA hydratase
SRS16CHR_05320	COG2197	response regulator
SRS16CHR_05322	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16CHR_05323	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SRS16CHR_05328	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SRS16CHR_05330	COG0183	Belongs to the thiolase family
SRS16CHR_05331	COG2030	dehydratase
SRS16CHR_05332	COG1024	Enoyl-CoA hydratase
SRS16CHR_05333	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16CHR_05333	COG1024	Enoyl-CoA hydratase
SRS16CHR_05334	COG1024	Enoyl-CoA hydratase
SRS16CHR_05335	COG1960	acyl-CoA dehydrogenase activity
SRS16CHR_05336	COG2368	4-hydroxyphenylacetate
SRS16CHR_05348	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16CHR_05350	COG1522	sequence-specific DNA binding
SRS16CHR_05351	COG0625	glutathione transferase activity
SRS16CHR_05354	COG5001	Diguanylate cyclase
SRS16CHR_05354	COG5002	protein histidine kinase activity
SRS16CHR_05359	COG0586	Pfam SNARE associated Golgi protein
SRS16CHR_05363	COG3622	Belongs to the hyi family
SRS16CHR_05364	COG3395	kinase activity
SRS16CHR_05365	COG2084	Dehydrogenase
SRS16CHR_05367	COG1522	sequence-specific DNA binding
SRS16CHR_05371	COG4566	intracellular signal transduction
SRS16CHR_05375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SRS16CHR_05380	COG0625	glutathione transferase activity
SRS16CHR_05386	COG0861	Integral membrane protein TerC family
SRS16CHR_05388	COG1950	PFAM Membrane protein of
SRS16CHR_05390	COG4783	chaperone-mediated protein folding
SRS16CHR_05391	COG0315	cyclic pyranopterin monophosphate synthase activity
SRS16CHR_05400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SRS16CHR_05402	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SRS16CHR_05408	COG3307	-O-antigen
SRS16CHR_05409	COG4969	Belongs to the N-Me-Phe pilin family
SRS16CHR_05413	COG0861	Integral membrane protein TerC family
SRS16CHR_05414	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SRS16CHR_05415	COG0045	succinate-CoA ligase (ADP-forming) activity
SRS16CHR_05416	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SRS16CHR_05417	COG2137	regulation of response to DNA damage stimulus
SRS16CHR_05418	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SRS16CHR_05421	COG0642	Histidine kinase
SRS16CHR_05423	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SRS16CHR_05423	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SRS16CHR_05425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SRS16CHR_05425	COG0551	DNA topoisomerase type I activity
SRS16CHR_05427	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SRS16CHR_05429	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SRS16CHR_05431	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SRS16CHR_05432	COG0513	Belongs to the DEAD box helicase family
SRS16CHR_05437	COG1473	amidohydrolase
SRS16CHR_05440	COG0129	dihydroxy-acid dehydratase activity
SRS16CHR_05441	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SRS16CHR_05443	COG3842	ATPase activity
SRS16CHR_05446	COG3833	ABC-type maltose transport systems, permease component
SRS16CHR_05447	COG2982	Protein involved in outer membrane biogenesis
SRS16CHR_05451	COG1047	Peptidyl-prolyl cis-trans
SRS16CHR_05453	COG0765	amino acid transport
SRS16CHR_05454	COG0765	amino acid transport
SRS16CHR_05465	COG2814	Major facilitator Superfamily
SRS16CHR_05467	COG0583	DNA-binding transcription factor activity
SRS16CHR_05468	COG0165	Argininosuccinate lyase
SRS16CHR_05472	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16CHR_05473	COG0667	Aldo Keto reductase
SRS16CHR_05475	COG1522	sequence-specific DNA binding
SRS16CHR_05476	COG2423	ornithine cyclodeaminase activity
SRS16CHR_05478	COG2094	Belongs to the DNA glycosylase MPG family
SRS16CHR_05488	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SRS16CHR_05494	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SRS16CHR_05495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SRS16CHR_05496	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SRS16CHR_05499	COG0006	proline dipeptidase activity
SRS16CHR_05502	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SRS16CHR_05506	COG0280	phosphate acetyltransferase
SRS16CHR_05506	COG0281	malic enzyme
SRS16CHR_05509	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SRS16CHR_05510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SRS16CHR_05511	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SRS16CHR_05513	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SRS16CHR_05515	COG3753	Protein conserved in bacteria
SRS16CHR_05516	COG2814	Major facilitator Superfamily
SRS16CHR_05517	COG2267	carboxylic ester hydrolase activity
SRS16CHR_05521	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SRS16CHR_05522	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SRS16CHR_05523	COG0724	RNA recognition motif
SRS16CHR_05524	COG0300	oxidoreductase activity
SRS16CHR_05526	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SRS16CHR_05530	COG2066	Belongs to the glutaminase family
SRS16CHR_05530	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SRS16CHR_05531	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SRS16CHR_05532	COG0706	membrane insertase activity
SRS16CHR_05533	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SRS16CHR_05534	COG0594	ribonuclease P activity
SRS16CHR_05535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SRS16P1_00001	COG1192	Involved in chromosome partitioning
SRS16P1_00004	COG1199	ATP-dependent helicase activity
SRS16P1_00037	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SRS16P1_00048	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SRS16P1_00053	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SRS16P1_00054	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SRS16P1_00062	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SRS16P1_00063	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SRS16P1_00117	COG4682	membrane
SRS16P1_00118	COG0433	COG0433 Predicted ATPase
SRS16P1_00137	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SRS16P1_00137	COG0551	DNA topoisomerase type I activity
SRS16P1_00151	COG4974	Belongs to the 'phage' integrase family
SRS16P1_00186	COG0545	Peptidyl-prolyl cis-trans isomerase
SRS16P1_00188	COG2954	triphosphatase activity
SRS16P1_00206	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SRS16P1_00213	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SRS16P1_00225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SRS16P1_00229	COG3011	Protein conserved in bacteria
SRS16P1_00248	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SRS16P1_00270	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SRS16P1_00272	COG0215	cysteine-tRNA ligase activity
SRS16P1_00321	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SRS16P1_00340	COG1074	ATP-dependent DNA helicase activity
SRS16P1_00347	COG4286	Uncharacterised protein family (UPF0160)
SRS16P1_00354	COG0519	Catalyzes the synthesis of GMP from XMP
SRS16P1_00354	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SRS16P1_00366	COG2801	Transposase and inactivated derivatives
SRS16P1_00368	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P1_00372	COG1454	alcohol dehydrogenase
SRS16P1_00375	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P1_00376	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SRS16P1_00384	COG1484	DNA-dependent DNA replication
SRS16P1_00389	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SRS16P1_00428	COG4650	regulator
SRS16P1_00444	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SRS16P1_00449	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SRS16P1_00500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SRS16P1_00505	COG4637	Psort location Cytoplasmic, score
SRS16P1_00512	COG1518	maintenance of DNA repeat elements
SRS16P1_00513	COG1203	CRISPR-associated helicase, Cas3
SRS16P1_00514	COG0587	DNA-directed DNA polymerase activity
SRS16P1_00528	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SRS16P1_00538	COG0084	hydrolase, TatD family'
SRS16P1_00598	COG2268	Band 7 protein
SRS16P1_00603	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SRS16P1_00609	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SRS16P1_00611	COG0628	permease
SRS16P1_00613	COG1129	ABC transporter
SRS16P1_00620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SRS16P1_00633	COG0675	Transposase, IS605 OrfB family
SRS16P1_00641	COG1222	aaa ATPase
SRS16P1_00642	COG1199	ATP-dependent helicase activity
SRS16P1_00652	COG0557	exoribonuclease II activity
SRS16P1_00671	COG0617	tRNA 3'-terminal CCA addition
SRS16P1_00674	COG1056	cytidyltransferase-related domain
SRS16P1_00674	COG1051	belongs to the nudix hydrolase family
SRS16P1_00678	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SRS16P1_00678	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SRS16P1_00686	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SRS16P1_00701	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SRS16P1_00711	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SRS16P1_00712	COG1484	DNA-dependent DNA replication
SRS16P1_00716	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SRS16P1_00722	COG0494	nUDIX hydrolase
SRS16P1_00737	COG4974	Belongs to the 'phage' integrase family
SRS16P1_00770	COG0328	RNA-DNA hybrid ribonuclease activity
SRS16P1_00780	COG0629	single-stranded DNA binding
SRS16P1_00787	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SRS16P1_00794	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SRS16P1_00794	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SRS16P1_00821	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SRS16P1_00822	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SRS16P1_00830	COG0840	transmembrane signaling receptor activity
SRS16P1_00831	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SRS16P1_00846	COG0582	viral genome integration into host DNA
SRS16P1_00871	COG0210	DNA helicase
SRS16P1_00879	COG0653	protein targeting
SRS16P1_00886	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SRS16P1_00888	COG1484	DNA-dependent DNA replication
SRS16P1_00890	COG0187	DNA topoisomerase II activity
SRS16P1_00891	COG0739	heme binding
SRS16P1_00891	COG1196	nuclear chromosome segregation
SRS16P1_00891	COG0741	lytic transglycosylase activity
SRS16P1_00892	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SRS16P1_00898	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SRS16P2_00001	COG1192	Involved in chromosome partitioning
SRS16P2_00013	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SRS16P2_00015	COG2301	Belongs to the HpcH HpaI aldolase family
SRS16P2_00017	COG1301	dicarboxylic acid transport
SRS16P2_00018	COG0583	DNA-binding transcription factor activity
SRS16P2_00020	COG2828	Protein conserved in bacteria
SRS16P2_00026	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SRS16P2_00028	COG1473	amidohydrolase
SRS16P2_00030	COG0129	dihydroxy-acid dehydratase activity
SRS16P2_00031	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SRS16P2_00034	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SRS16P2_00036	COG1522	sequence-specific DNA binding
SRS16P2_00037	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SRS16P2_00040	COG3328	transposase activity
SRS16P2_00041	COG0735	belongs to the Fur family
SRS16P2_00043	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16P2_00046	COG1522	sequence-specific DNA binding
SRS16P2_00047	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SRS16P2_00054	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16P2_00055	COG4166	transmembrane transport
SRS16P2_00056	COG0601	transmembrane transport
SRS16P2_00057	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SRS16P2_00059	COG0473	3-isopropylmalate dehydrogenase activity
SRS16P2_00060	COG1012	belongs to the aldehyde dehydrogenase family
SRS16P2_00061	COG1252	NADH dehydrogenase
SRS16P2_00063	COG0196	riboflavin kinase activity
SRS16P2_00065	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00069	COG3485	protocatechuate 3,4-dioxygenase
SRS16P2_00071	COG2814	Major facilitator Superfamily
SRS16P2_00073	COG1063	alcohol dehydrogenase
SRS16P2_00081	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00083	COG0583	DNA-binding transcription factor activity
SRS16P2_00086	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00088	COG0492	ferredoxin-NADP+ reductase activity
SRS16P2_00091	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SRS16P2_00092	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SRS16P2_00097	COG0583	DNA-binding transcription factor activity
SRS16P2_00099	COG1012	belongs to the aldehyde dehydrogenase family
SRS16P2_00103	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00105	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16P2_00110	COG1024	Enoyl-CoA hydratase
SRS16P2_00111	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SRS16P2_00113	COG3386	PFAM SMP-30 Gluconolaconase
SRS16P2_00115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00116	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00117	COG1024	Enoyl-CoA hydratase
SRS16P2_00119	COG0667	Aldo Keto reductase
SRS16P2_00125	COG2188	Transcriptional regulator
SRS16P2_00126	COG1454	alcohol dehydrogenase
SRS16P2_00131	COG0667	Aldo Keto reductase
SRS16P2_00132	COG0667	Aldo Keto reductase
SRS16P2_00134	COG0667	Aldo Keto reductase
SRS16P2_00142	COG0589	response to stress
SRS16P2_00146	COG0583	DNA-binding transcription factor activity
SRS16P2_00149	COG2801	Transposase and inactivated derivatives
SRS16P2_00151	COG2801	Transposase and inactivated derivatives
SRS16P2_00152	COG2337	Toxic component of a toxin-antitoxin (TA) module
SRS16P2_00163	COG3328	transposase activity
SRS16P2_00169	COG0583	DNA-binding transcription factor activity
SRS16P2_00193	COG1022	Amp-dependent synthetase and ligase
SRS16P2_00197	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16P2_00203	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P2_00204	COG1309	transcriptional regulator
SRS16P2_00206	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00209	COG1250	3-hydroxyacyl-CoA dehydrogenase
SRS16P2_00210	COG1024	Enoyl-CoA hydratase
SRS16P2_00211	COG1024	Enoyl-CoA hydratase
SRS16P2_00212	COG0183	Belongs to the thiolase family
SRS16P2_00213	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SRS16P2_00215	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00218	COG4638	Rieske (2fe-2S)
SRS16P2_00233	COG0028	Belongs to the TPP enzyme family
SRS16P2_00235	COG4638	Rieske (2fe-2S)
SRS16P2_00237	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00238	COG2175	clavaminate synthase activity
SRS16P2_00239	COG0028	Belongs to the TPP enzyme family
SRS16P2_00242	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00242	COG3347	Dehydrogenase
SRS16P2_00245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00246	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00249	COG0028	Belongs to the TPP enzyme family
SRS16P2_00251	COG1012	belongs to the aldehyde dehydrogenase family
SRS16P2_00253	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P2_00254	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00259	COG0583	DNA-binding transcription factor activity
SRS16P2_00263	COG0183	Belongs to the thiolase family
SRS16P2_00266	COG1024	Enoyl-CoA hydratase
SRS16P2_00267	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00269	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SRS16P2_00270	COG2079	MmgE PrpD family protein
SRS16P2_00271	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00272	COG1609	Transcriptional regulator
SRS16P2_00290	COG1234	tRNA 3'-trailer cleavage
SRS16P2_00295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16P2_00296	COG2159	amidohydrolase
SRS16P2_00297	COG3618	amidohydrolase
SRS16P2_00299	COG3547	Transposase (IS116 IS110 IS902 family)
SRS16P2_00306	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00310	COG1024	Enoyl-CoA hydratase
SRS16P2_00312	COG1902	pentaerythritol trinitrate reductase activity
SRS16P2_00313	COG1024	Enoyl-CoA hydratase
SRS16P2_00314	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00316	COG1024	Enoyl-CoA hydratase
SRS16P2_00317	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00318	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00319	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00320	COG1024	Enoyl-CoA hydratase
SRS16P2_00321	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P2_00325	COG0045	succinate-CoA ligase (ADP-forming) activity
SRS16P2_00325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SRS16P2_00325	COG1042	CoA-binding domain protein
SRS16P2_00326	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00327	COG1024	Enoyl-CoA hydratase
SRS16P2_00328	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SRS16P2_00328	COG0045	succinate-CoA ligase (ADP-forming) activity
SRS16P2_00328	COG1042	CoA-binding domain protein
SRS16P2_00330	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00331	COG1960	acyl-CoA dehydrogenase activity
SRS16P2_00332	COG1024	Enoyl-CoA hydratase
SRS16P2_00333	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00334	COG2030	dehydratase
SRS16P2_00336	COG0583	DNA-binding transcription factor activity
SRS16P2_00337	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00338	COG2070	2-Nitropropane dioxygenase
SRS16P2_00339	COG2130	NADP-dependent
SRS16P2_00341	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00344	COG4453	Protein conserved in bacteria
SRS16P2_00350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SRS16P2_00353	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SRS16P2_00355	COG2801	Transposase and inactivated derivatives
SRS16P2_00357	COG4372	Transposase
SRS16P2_00361	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SRS16P2_00362	COG5383	Protein conserved in bacteria
SRS16P2_00363	COG0525	valine-tRNA ligase activity
SRS16P2_00364	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SRS16P2_00365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SRS16P2_00366	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SRS16P2_00370	COG0559	Belongs to the binding-protein-dependent transport system permease family
SRS16P2_00372	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SRS16P2_00373	COG0277	FAD linked oxidase domain protein
SRS16P2_00374	COG0028	Belongs to the TPP enzyme family
SRS16P2_00376	COG5642	Protein of unknown function (DUF2384)
SRS16P2_00378	COG4191	Histidine kinase
SRS16P2_00378	COG0784	Response regulator, receiver
SRS16P2_00382	COG0604	alcohol dehydrogenase
SRS16P2_00384	COG0300	oxidoreductase activity
SRS16P2_00385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SRS16P2_00386	COG0800	Aldolase
SRS16P2_00388	COG1012	belongs to the aldehyde dehydrogenase family
SRS16P2_00396	COG0642	Histidine kinase
SRS16P2_00403	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SRS16P2_00405	COG4638	Rieske (2fe-2S)
SRS16P2_00406	COG2267	carboxylic ester hydrolase activity
SRS16P2_00410	COG2309	aminopeptidase activity
SRS16P2_00412	COG1335	isochorismatase
SRS16P2_00413	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16P2_00420	COG4372	Transposase
SRS16P2_00423	COG2801	Transposase and inactivated derivatives
SRS16P2_00424	COG2801	Transposase and inactivated derivatives
SRS16P2_00427	COG4372	Transposase
SRS16P2_00430	COG0596	Alpha beta hydrolase
SRS16P2_00439	COG2309	aminopeptidase activity
SRS16P2_00440	COG1335	isochorismatase
SRS16P2_00446	COG2223	nitrite transmembrane transporter activity
SRS16P2_00453	COG1024	Enoyl-CoA hydratase
SRS16P2_00456	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P2_00457	COG0183	Belongs to the thiolase family
SRS16P2_00470	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SRS16P2_00472	COG2184	nucleotidyltransferase activity
SRS16P2_00498	COG1063	alcohol dehydrogenase
SRS16P2_00499	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16P2_00500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SRS16P2_00501	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SRS16P2_00502	COG0246	Mannitol dehydrogenase
SRS16P2_00504	COG1024	Enoyl-CoA hydratase
SRS16P2_00508	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P2_00513	COG0583	DNA-binding transcription factor activity
SRS16P2_00515	COG3293	Transposase
SRS16P2_00518	COG3300	MHYT domain
SRS16P2_00518	COG5001	Diguanylate cyclase
SRS16P2_00533	COG3846	protein secretion by the type IV secretion system
SRS16P2_00537	COG3504	Conjugal transfer protein
SRS16P2_00539	COG3451	type IV secretory pathway VirB4
SRS16P2_00540	COG5268	conjugation
SRS16P2_00541	COG3838	Conjugal transfer protein Trbc
SRS16P2_00542	COG4962	Type ii secretion system protein e
SRS16P2_00550	COG1199	ATP-dependent helicase activity
SRS16P3_00001	COG1192	Involved in chromosome partitioning
SRS16P3_00005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SRS16P3_00008	COG1960	acyl-CoA dehydrogenase activity
SRS16P3_00010	COG2030	dehydratase
SRS16P3_00011	COG0183	Belongs to the thiolase family
SRS16P3_00014	COG1960	acyl-CoA dehydrogenase activity
SRS16P3_00015	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SRS16P3_00016	COG0425	Belongs to the sulfur carrier protein TusA family
SRS16P3_00016	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SRS16P3_00018	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P3_00021	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00024	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SRS16P3_00030	COG0583	DNA-binding transcription factor activity
SRS16P3_00034	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SRS16P3_00035	COG0583	DNA-binding transcription factor activity
SRS16P3_00044	COG0604	alcohol dehydrogenase
SRS16P3_00044	COG3321	synthase
SRS16P3_00044	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P3_00046	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SRS16P3_00051	COG3119	arylsulfatase activity
SRS16P3_00054	COG0583	DNA-binding transcription factor activity
SRS16P3_00056	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00058	COG2084	Dehydrogenase
SRS16P3_00061	COG0439	Biotin carboxylase
SRS16P3_00065	COG1309	transcriptional regulator
SRS16P3_00066	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SRS16P3_00069	COG1024	Enoyl-CoA hydratase
SRS16P3_00073	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P3_00074	COG1960	acyl-CoA dehydrogenase activity
SRS16P3_00081	COG2072	flavoprotein involved in K transport
SRS16P3_00085	COG1120	ATPase activity
SRS16P3_00091	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P3_00094	COG4566	intracellular signal transduction
SRS16P3_00097	COG2831	hemolysin activation secretion protein
SRS16P3_00102	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00104	COG4948	Mandelate Racemase Muconate Lactonizing
SRS16P3_00108	COG3842	ATPase activity
SRS16P3_00113	COG3386	PFAM SMP-30 Gluconolaconase
SRS16P3_00117	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SRS16P3_00119	COG2197	response regulator
SRS16P3_00120	COG4585	Histidine kinase
SRS16P3_00121	COG2205	protein histidine kinase activity
SRS16P3_00121	COG2202	Pas domain
SRS16P3_00122	COG0667	Aldo Keto reductase
SRS16P3_00124	COG0765	amino acid transport
SRS16P3_00125	COG0765	amino acid transport
SRS16P3_00126	COG1126	abc transporter atp-binding protein
SRS16P3_00128	COG1522	sequence-specific DNA binding
SRS16P3_00132	COG3268	Saccharopine dehydrogenase
SRS16P3_00133	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P3_00137	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P3_00139	COG0154	amidase activity
SRS16P3_00141	COG2301	Belongs to the HpcH HpaI aldolase family
SRS16P3_00142	COG0183	Belongs to the thiolase family
SRS16P3_00143	COG0604	alcohol dehydrogenase
SRS16P3_00148	COG1024	Enoyl-CoA hydratase
SRS16P3_00149	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P3_00150	COG2814	Major facilitator Superfamily
SRS16P3_00152	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SRS16P3_00154	COG0583	DNA-binding transcription factor activity
SRS16P3_00155	COG3210	domain, Protein
SRS16P3_00156	COG2831	hemolysin activation secretion protein
SRS16P3_00161	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P3_00163	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00164	COG1053	succinate dehydrogenase
SRS16P3_00167	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00169	COG0165	Argininosuccinate lyase
SRS16P3_00170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRS16P3_00172	COG0765	amino acid transport
SRS16P3_00173	COG0010	Belongs to the arginase family
SRS16P3_00175	COG0579	oxidoreductase
SRS16P3_00178	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SRS16P3_00179	COG1473	amidohydrolase
SRS16P3_00180	COG0251	oxidation-reduction process
SRS16P3_00182	COG1116	anion transmembrane transporter activity
SRS16P3_00183	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SRS16P3_00184	COG0154	amidase activity
SRS16P3_00186	COG0156	8-amino-7-oxononanoate synthase activity
SRS16P3_00189	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SRS16P3_00193	COG1335	isochorismatase
SRS16P3_00196	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SRS16P3_00198	COG0791	NLP P60 protein
SRS16P3_00200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SRS16P3_00206	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16P3_00207	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SRS16P3_00212	COG3386	PFAM SMP-30 Gluconolaconase
SRS16P3_00213	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SRS16P3_00215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRS16P3_00217	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P3_00222	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P3_00224	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SRS16P3_00225	COG0439	Biotin carboxylase
SRS16P3_00227	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00232	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00237	COG1172	Belongs to the binding-protein-dependent transport system permease family
SRS16P3_00240	COG0066	3-isopropylmalate dehydratase activity
SRS16P3_00241	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SRS16P3_00242	COG0277	FAD linked oxidase domain protein
SRS16P3_00246	COG0028	Belongs to the TPP enzyme family
SRS16P3_00252	COG1126	abc transporter atp-binding protein
SRS16P3_00254	COG0765	amino acid transport
SRS16P3_00257	COG0583	DNA-binding transcription factor activity
SRS16P3_00259	COG0625	glutathione transferase activity
SRS16P3_00267	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00268	COG0583	DNA-binding transcription factor activity
SRS16P3_00269	COG0604	alcohol dehydrogenase
SRS16P3_00271	COG1024	Enoyl-CoA hydratase
SRS16P3_00273	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SRS16P3_00281	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SRS16P3_00282	COG1414	Transcriptional regulator
SRS16P3_00286	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SRS16P3_00287	COG0586	Pfam SNARE associated Golgi protein
SRS16P3_00289	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SRS16P3_00289	COG1672	PFAM Archaeal ATPase
SRS16P3_00293	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P3_00294	COG1028	Short-chain dehydrogenase reductase Sdr
SRS16P3_00297	COG1176	ABC-type spermidine putrescine transport system, permease component I
SRS16P3_00298	COG3842	ATPase activity
SRS16P3_00299	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SRS16P3_00303	COG0439	Biotin carboxylase
SRS16P3_00304	COG0511	ligase activity, forming carbon-carbon bonds
SRS16P3_00306	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SRS16P3_00307	COG2721	sulfolactate sulfo-lyase activity
SRS16P3_00310	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SRS16P3_00311	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SRS16P3_00312	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SRS16P3_00316	COG0445	tRNA wobble uridine modification
SRS16P3_00317	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00319	COG1960	acyl-CoA dehydrogenase activity
SRS16P3_00323	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P3_00324	COG1414	Transcriptional regulator
SRS16P3_00331	COG1053	succinate dehydrogenase
SRS16P3_00332	COG2079	MmgE PrpD family protein
SRS16P3_00333	COG0523	cobalamin synthesis protein
SRS16P3_00335	COG1335	isochorismatase
SRS16P3_00337	COG3550	peptidyl-serine autophosphorylation
SRS16P3_00338	COG1760	l-serine dehydratase
SRS16P3_00340	COG1335	isochorismatase
SRS16P3_00343	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16P3_00344	COG4569	acetaldehyde dehydrogenase (acetylating) activity
SRS16P3_00359	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SRS16P3_00359	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SRS16P3_00374	COG2207	Transcriptional regulator
SRS16P3_00375	COG0789	Transcriptional regulator
SRS16P3_00384	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00385	COG0235	Class ii aldolase
SRS16P3_00386	COG1024	Enoyl-CoA hydratase
SRS16P3_00388	COG3119	arylsulfatase activity
SRS16P3_00397	COG1917	Cupin 2, conserved barrel domain protein
SRS16P3_00399	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00401	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SRS16P3_00402	COG4569	acetaldehyde dehydrogenase (acetylating) activity
SRS16P3_00416	COG0583	DNA-binding transcription factor activity
SRS16P3_00417	COG0583	DNA-binding transcription factor activity
SRS16P3_00420	COG3181	Tripartite tricarboxylate transporter family receptor
SRS16P3_00421	COG2814	Major facilitator Superfamily
SRS16P3_00424	COG3639	organic phosphonate transmembrane transporter activity
SRS16P3_00425	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SRS16P3_00426	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SRS16P3_00427	COG3454	Phosphonate metabolism
SRS16P3_00428	COG4778	phosphonate C-P lyase system protein PhnL
SRS16P3_00429	COG4107	phosphonate C-P lyase system protein PhnK
SRS16P3_00430	COG3627	carbon phosphorus lyase activity
SRS16P3_00431	COG3626	phosphonate metabolism
SRS16P3_00433	COG3624	Phosphonate C-P lyase system protein PhnG
SRS16P3_00434	COG1609	Transcriptional regulator
SRS16P3_00435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SRS16P3_00436	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SRS16P3_00438	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P3_00441	COG1024	Enoyl-CoA hydratase
SRS16P3_00446	COG0183	Belongs to the thiolase family
SRS16P3_00449	COG1024	Enoyl-CoA hydratase
SRS16P3_00450	COG0318	PFAM AMP-dependent synthetase and ligase
SRS16P3_00453	COG4566	intracellular signal transduction
SRS16P3_00458	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SRS16P3_00461	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SRS16P3_00464	COG2175	clavaminate synthase activity
SRS16P4_00016	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SRS16P4_00020	COG1121	(ABC) transporter
SRS16P4_00035	COG3701	Conjugal transfer protein
SRS16P4_00036	COG3451	type IV secretory pathway VirB4
SRS16P4_00037	COG5268	conjugation
SRS16P4_00038	COG3838	Conjugal transfer protein Trbc
SRS16P4_00039	COG4962	Type ii secretion system protein e
SRS16P4_00046	COG0517	IMP dehydrogenase activity
SRS16P4_00049	COG0517	IMP dehydrogenase activity
SRS16P4_00058	COG4584	PFAM Integrase catalytic
SRS16P4_00059	COG1484	DNA-dependent DNA replication