locus-tag	class	description
B7L28_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B7L28_00010	COG0592	DNA-directed DNA polymerase activity
B7L28_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L28_00035	COG0187	DNA topoisomerase II activity
B7L28_00040	COG0833	amino acid
B7L28_00060	COG1253	flavin adenine dinucleotide binding
B7L28_00095	COG0859	PFAM glycosyl transferase family 9
B7L28_00120	COG0438	transferase activity, transferring glycosyl groups
B7L28_00140	COG0561	phosphatase activity
B7L28_00150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B7L28_00155	COG1481	regulation of sporulation
B7L28_00165	COG0540	Belongs to the ATCase OTCase family
B7L28_00185	COG0543	2 iron, 2 sulfur cluster binding
B7L28_00190	COG0167	dihydroorotate dehydrogenase activity
B7L28_00195	COG0583	DNA-binding transcription factor activity
B7L28_00205	COG1739	Uncharacterized protein family UPF0029
B7L28_00210	COG2217	Heavy metal translocating P-type atpase
B7L28_00220	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B7L28_00225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7L28_00245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B7L28_00250	COG0336	Belongs to the RNA methyltransferase TrmD family
B7L28_00285	COG4752	Belongs to the RNA methyltransferase TrmD family
B7L28_00290	COG0217	transcriptional regulatory protein
B7L28_00295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B7L28_00300	COG0632	four-way junction helicase activity
B7L28_00310	COG2385	sporulation resulting in formation of a cellular spore
B7L28_00310	COG2247	cell wall binding repeat
B7L28_00320	COG0343	queuine tRNA-ribosyltransferase activity
B7L28_00325	COG1862	Preprotein translocase
B7L28_00335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L28_00340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L28_00345	COG2814	Major facilitator Superfamily
B7L28_00375	COG0497	DNA recombination
B7L28_00410	COG0497	DNA recombination
B7L28_00425	COG0497	DNA recombination
B7L28_00430	COG0497	DNA recombination
B7L28_00455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L28_00475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L28_00475	COG4797	methyltransferase
B7L28_00530	COG0501	Belongs to the peptidase M48B family
B7L28_00545	COG0811	peptide transport
B7L28_00550	COG0848	biopolymer transport protein
B7L28_00560	COG4771	TonB-dependent receptor
B7L28_00570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_00575	COG1120	ATPase activity
B7L28_00595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_00600	COG1120	ATPase activity
B7L28_00625	COG4206	TonB-dependent receptor
B7L28_00630	COG0436	Aminotransferase
B7L28_00650	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B7L28_00670	COG4221	oxidoreductase activity
B7L28_00695	COG0747	negative chemotaxis
B7L28_00700	COG0444	Belongs to the ABC transporter superfamily
B7L28_00735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L28_00740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B7L28_00745	COG0066	3-isopropylmalate dehydratase activity
B7L28_00750	COG0473	3-isopropylmalate dehydrogenase activity
B7L28_00780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B7L28_00785	COG3550	peptidyl-serine autophosphorylation
B7L28_00810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B7L28_00825	COG0561	phosphatase activity
B7L28_00835	COG0519	Catalyzes the synthesis of GMP from XMP
B7L28_00835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L28_00885	COG0456	acetyltransferase
B7L28_00890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7L28_00895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7L28_00900	COG1121	(ABC) transporter
B7L28_00905	COG0803	Belongs to the bacterial solute-binding protein 9 family
B7L28_00930	COG1151	hydroxylamine reductase activity
B7L28_00935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B7L28_00945	COG2223	nitrite transmembrane transporter activity
B7L28_00950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L28_00955	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B7L28_00960	COG1140	nitrate reductase beta subunit
B7L28_00965	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B7L28_00970	COG2181	nitrate reductase activity
B7L28_00985	COG2814	Major facilitator Superfamily
B7L28_00990	COG0583	DNA-binding transcription factor activity
B7L28_00995	COG1279	arginine transmembrane transporter activity
B7L28_01000	COG2855	membrane
B7L28_01005	COG0288	reversible hydration of carbon dioxide
B7L28_01015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B7L28_01020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B7L28_01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7L28_01040	COG1121	(ABC) transporter
B7L28_01045	COG0803	Belongs to the bacterial solute-binding protein 9 family
B7L28_01080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B7L28_01085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B7L28_01090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B7L28_01095	COG1882	Formate acetyltransferase
B7L28_01120	COG2011	ABC-type metal ion transport system permease component
B7L28_01130	COG0471	metal ion transport
B7L28_01150	COG1196	nuclear chromosome segregation
B7L28_01175	COG3659	wide pore channel activity
B7L28_01180	COG1879	ABC-type sugar transport system periplasmic component
B7L28_01185	COG1172	Belongs to the binding-protein-dependent transport system permease family
B7L28_01190	COG1129	ABC transporter
B7L28_01195	COG1869	D-ribose catabolic process
B7L28_01200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L28_01215	COG1122	ATPase activity
B7L28_01220	COG1122	ATPase activity
B7L28_01245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B7L28_01250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B7L28_01255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B7L28_01260	COG0131	Imidazoleglycerol-phosphate dehydratase
B7L28_01265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B7L28_01270	COG0107	imidazoleglycerol-phosphate synthase activity
B7L28_01275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B7L28_01280	COG0140	phosphoribosyl-ATP diphosphatase activity
B7L28_01285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L28_01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B7L28_01295	COG1966	Carbon starvation protein
B7L28_01300	COG0004	ammonium transporteR
B7L28_01345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L28_01355	COG1045	serine acetyltransferase
B7L28_01375	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L28_01385	COG3022	response to hydroperoxide
B7L28_01390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L28_01400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B7L28_01405	COG2731	YhcH YjgK YiaL family protein
B7L28_01420	COG2184	nucleotidyltransferase activity
B7L28_01430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L28_01455	COG0512	Glutamine amidotransferase of anthranilate synthase
B7L28_01455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L28_01470	COG0133	tryptophan synthase activity
B7L28_01475	COG0159	tryptophan synthase activity
B7L28_01485	COG3152	Membrane
B7L28_01495	COG0626	cystathionine gamma-synthase activity
B7L28_01500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B7L28_01505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B7L28_01530	COG0701	Predicted permease
B7L28_01535	COG0523	cobalamin synthesis protein
B7L28_01540	COG2195	Cleaves the N-terminal amino acid of tripeptides
B7L28_01545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B7L28_01555	COG0252	asparaginase activity
B7L28_01565	COG0668	transmembrane transport
B7L28_01570	COG1686	Belongs to the peptidase S11 family
B7L28_01580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L28_01590	COG2080	2 iron, 2 sulfur cluster binding
B7L28_01595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L28_01595	COG2080	2 iron, 2 sulfur cluster binding
B7L28_01605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L28_01610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B7L28_01610	COG3608	succinylglutamate desuccinylase aspartoacylase
B7L28_01615	COG3608	succinylglutamate desuccinylase aspartoacylase
B7L28_01615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B7L28_01625	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B7L28_01635	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B7L28_01640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L28_01650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L28_01655	COG0180	Tryptophanyl-tRNA synthetase
B7L28_01670	COG0765	amino acid transport
B7L28_01675	COG1126	abc transporter atp-binding protein
B7L28_01685	COG0589	response to stress
B7L28_01690	COG0640	Transcriptional regulator
B7L28_01700	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7L28_01705	COG4149	molybdate abc transporter
B7L28_01710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7L28_01730	COG1592	Rubrerythrin
B7L28_01740	COG0709	Synthesizes selenophosphate from selenide and ATP
B7L28_01755	COG3177	Filamentation induced by cAMP protein fic
B7L28_01760	COG0778	Nitroreductase
B7L28_01765	COG2261	transglycosylase associated protein
B7L28_01770	COG3237	CsbD-like
B7L28_01775	COG0012	GTP binding
B7L28_01780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L28_01790	COG3468	outer membrane autotransporter barrel domain protein
B7L28_01810	COG0360	Binds together with S18 to 16S ribosomal RNA
B7L28_01815	COG0629	single-stranded DNA binding
B7L28_01820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B7L28_01830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B7L28_01835	COG0772	Belongs to the SEDS family
B7L28_01840	COG2233	PERMEase
B7L28_01845	COG1030	water channel activity
B7L28_01850	COG4864	UPF0365 protein
B7L28_01880	COG2195	Cleaves the N-terminal amino acid of tripeptides
B7L28_01895	COG2040	homocysteine
B7L28_01900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L28_01905	COG1116	anion transmembrane transporter activity
B7L28_01920	COG0426	domain, Protein
B7L28_01920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L28_01925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7L28_01930	COG0583	DNA-binding transcription factor activity
B7L28_01935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L28_01950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B7L28_01955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B7L28_01960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B7L28_01965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B7L28_01970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B7L28_01980	COG0151	Belongs to the GarS family
B7L28_01985	COG1169	isochorismate synthase
B7L28_01990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B7L28_01995	COG0596	Alpha beta hydrolase
B7L28_02000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B7L28_02005	COG0318	PFAM AMP-dependent synthetase and ligase
B7L28_02075	COG0726	polysaccharide deacetylase
B7L28_02075	COG1649	PFAM Uncharacterised BCR, COG1649
B7L28_02080	COG4632	Exopolysaccharide biosynthesis protein
B7L28_02080	COG5434	Belongs to the glycosyl hydrolase 28 family
B7L28_02090	COG0859	PFAM glycosyl transferase family 9
B7L28_02100	COG0511	ligase activity, forming carbon-carbon bonds
B7L28_02100	COG5016	pyruvate
B7L28_02105	COG5002	protein histidine kinase activity
B7L28_02110	COG0745	RESPONSE REGULATOR receiver
B7L28_02115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L28_02120	COG1695	Transcriptional regulator
B7L28_02135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B7L28_02140	COG0284	orotidine-5'-phosphate decarboxylase activity
B7L28_02145	COG2176	DNA-directed DNA polymerase activity
B7L28_02165	COG1464	Belongs to the NlpA lipoprotein family
B7L28_02170	COG1575	Belongs to the MenA family. Type 1 subfamily
B7L28_02185	COG0251	oxidation-reduction process
B7L28_02190	COG3681	Belongs to the UPF0597 family
B7L28_02195	COG2223	nitrite transmembrane transporter activity
B7L28_02215	COG2860	membrane
B7L28_02235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L28_02240	COG2011	ABC-type metal ion transport system permease component
B7L28_02245	COG4496	protein, YerC YecD
B7L28_02265	COG3339	Conserved Protein
B7L28_02270	COG0824	Thioesterase
B7L28_02275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B7L28_02300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B7L28_02305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B7L28_02315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B7L28_02320	COG0281	malic enzyme
B7L28_02350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B7L28_02355	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L28_02360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B7L28_02365	COG1984	allophanate hydrolase subunit 2
B7L28_02380	COG0534	Mate efflux family protein
B7L28_02385	COG0519	Catalyzes the synthesis of GMP from XMP
B7L28_02395	COG0628	permease
B7L28_02405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L28_02415	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B7L28_02420	COG2226	methyltransferase
B7L28_02445	COG0726	polysaccharide deacetylase
B7L28_02450	COG0521	Mo-molybdopterin cofactor biosynthetic process
B7L28_02460	COG0306	phosphate transporter
B7L28_02465	COG1959	2 iron, 2 sulfur cluster binding
B7L28_02470	COG1271	oxidase subunit
B7L28_02475	COG1294	oxidase, subunit
B7L28_02480	COG4988	ABC transporter
B7L28_02500	COG0601	transmembrane transport
B7L28_02505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L28_02510	COG0444	Belongs to the ABC transporter superfamily
B7L28_02515	COG4608	Belongs to the ABC transporter superfamily
B7L28_02525	COG4166	transmembrane transport
B7L28_02530	COG1619	proteins homologs of microcin C7 resistance protein MccF
B7L28_02535	COG1473	amidohydrolase
B7L28_02540	COG0488	(ABC) transporter
B7L28_02545	COG0302	gtp cyclohydrolase
B7L28_02550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B7L28_02555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B7L28_02560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7L28_02560	COG0302	gtp cyclohydrolase
B7L28_02570	COG2261	transglycosylase associated protein
B7L28_02575	COG0039	L-malate dehydrogenase activity
B7L28_02585	COG1098	S1 RNA binding domain
B7L28_02595	COG0037	tRNA processing
B7L28_02605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L28_02630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B7L28_02635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L28_02640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L28_02645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B7L28_02650	COG1982	Orn Lys Arg decarboxylase major
B7L28_02655	COG0531	amino acid
B7L28_02665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B7L28_02670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7L28_02675	COG1494	fructose-1,6-bisphosphatase
B7L28_02680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B7L28_02705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L28_02710	COG1127	ABC transporter
B7L28_02750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L28_02755	COG1560	Kdo2-lipid A biosynthetic process
B7L28_02760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B7L28_02765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L28_02770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L28_02775	COG3494	Protein of unknown function (DUF1009)
B7L28_02780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L28_02785	COG1132	(ABC) transporter
B7L28_02790	COG1519	Transferase
B7L28_02795	COG1663	tetraacyldisaccharide 4'-kinase activity
B7L28_02800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L28_02805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B7L28_02815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B7L28_02835	COG1137	ATPase activity
B7L28_02845	COG4372	Transposase
B7L28_02855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B7L28_02865	COG0497	DNA recombination
B7L28_02885	COG3585	molybdate ion transport
B7L28_02900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B7L28_02905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B7L28_02910	COG3583	domain protein
B7L28_02910	COG3584	3D domain protein
B7L28_02915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L28_02920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B7L28_02925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B7L28_02930	COG0193	aminoacyl-tRNA hydrolase activity
B7L28_02935	COG1982	Orn Lys Arg decarboxylase major
B7L28_02945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B7L28_02950	COG1774	PSP1 C-terminal conserved region
B7L28_02955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B7L28_02960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B7L28_02965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L28_02965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L28_02970	COG0084	hydrolase, TatD family'
B7L28_02975	COG0248	Ppx GppA phosphatase
B7L28_02985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B7L28_02990	COG1388	LysM domain
B7L28_02990	COG3584	3D domain protein
B7L28_02995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L28_02995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L28_03000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B7L28_03005	COG0583	DNA-binding transcription factor activity
B7L28_03010	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B7L28_03015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B7L28_03020	COG0786	glutamate:sodium symporter activity
B7L28_03025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B7L28_03030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L28_03045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B7L28_03045	COG1918	ferrous iron import across plasma membrane
B7L28_03095	COG0298	carbon dioxide binding
B7L28_03125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B7L28_03135	COG1268	BioY protein
B7L28_03145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7L28_03155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L28_03165	COG0166	Belongs to the GPI family
B7L28_03190	COG0559	Belongs to the binding-protein-dependent transport system permease family
B7L28_03205	COG0410	ABC transporter
B7L28_03230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B7L28_03240	COG3475	LICD family
B7L28_03300	COG1328	CTP reductase activity
B7L28_03305	COG0602	queuosine metabolic process
B7L28_03325	COG1773	rubredoxin
B7L28_03340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B7L28_03345	COG2030	dehydratase
B7L28_03350	COG0416	fatty acid biosynthetic process
B7L28_03355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L28_03365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B7L28_03370	COG1028	Short-chain dehydrogenase reductase Sdr
B7L28_03375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L28_03380	COG2070	2-Nitropropane dioxygenase
B7L28_03385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B7L28_03390	COG0571	ribonuclease III activity
B7L28_03400	COG1196	nuclear chromosome segregation
B7L28_03405	COG0552	protein localization to endoplasmic reticulum
B7L28_03415	COG0556	nucleotide-excision repair
B7L28_03420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B7L28_03425	COG0322	excinuclease ABC activity
B7L28_03435	COG0861	Integral membrane protein TerC family
B7L28_03440	COG0861	Integral membrane protein TerC family
B7L28_03445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L28_03465	COG4771	TonB-dependent receptor
B7L28_03515	COG1032	radical SAM domain protein
B7L28_03535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B7L28_03540	COG0179	Fumarylacetoacetate (FAA) hydrolase
B7L28_03550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L28_03565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L28_03575	COG0471	metal ion transport
B7L28_03580	COG1362	aminopeptidase activity
B7L28_03585	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B7L28_03590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B7L28_03600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B7L28_03605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B7L28_03605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B7L28_03610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L28_03615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B7L28_03620	COG0859	PFAM glycosyl transferase family 9
B7L28_03625	COG0859	PFAM glycosyl transferase family 9
B7L28_03635	COG1362	aminopeptidase activity
B7L28_03655	COG4120	Belongs to the binding-protein-dependent transport system permease family
B7L28_03660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B7L28_03665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B7L28_03670	COG1185	polyribonucleotide nucleotidyltransferase activity
B7L28_03675	COG0756	dUTP diphosphatase activity
B7L28_03680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L28_03725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B7L28_03730	COG0268	Binds directly to 16S ribosomal RNA
B7L28_03735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L28_03735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L28_03760	COG0195	Participates in both transcription termination and antitermination
B7L28_03770	COG1358	cellular component organization or biogenesis
B7L28_03775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B7L28_03775	COG3170	Tfp pilus assembly protein FimV
B7L28_03780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B7L28_03795	COG0196	riboflavin kinase activity
B7L28_03805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B7L28_03810	COG1040	competence protein
B7L28_03825	COG0765	amino acid transport
B7L28_03835	COG1278	Cold shock
B7L28_03840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B7L28_03845	COG0653	protein targeting
B7L28_03850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B7L28_03870	COG3959	Transketolase, thiamine diphosphate binding domain
B7L28_03875	COG3958	Transketolase
B7L28_03880	COG2884	Cell division ATP-binding protein ftsE
B7L28_03885	COG2177	Part of the ABC transporter FtsEX involved in
B7L28_03890	COG4942	peptidase
B7L28_03895	COG0793	Belongs to the peptidase S41A family
B7L28_03900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B7L28_03910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B7L28_03915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B7L28_03920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B7L28_03925	COG1713	HD superfamily hydrolase involved in NAD metabolism
B7L28_03930	COG1316	TRANSCRIPTIONal
B7L28_03935	COG0799	negative regulation of ribosome biogenesis
B7L28_03940	COG2996	Protein conserved in bacteria
B7L28_03945	COG0569	domain protein
B7L28_03950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B7L28_03955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L28_03985	COG1683	Conserved Protein
B7L28_03995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B7L28_04000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B7L28_04005	COG1187	pseudouridine synthase activity
B7L28_04010	COG2081	HI0933 family
B7L28_04025	COG0539	negative regulation of cytoplasmic translation
B7L28_04025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B7L28_04030	COG1160	GTP binding
B7L28_04035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B7L28_04040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B7L28_04045	COG0742	ribosomal rna small subunit methyltransferase
B7L28_04050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B7L28_04070	COG1561	YicC-like family, N-terminal region
B7L28_04075	COG2052	Domain of unknown function (DUF370)
B7L28_04080	COG0194	GDP metabolic process
B7L28_04090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7L28_04095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B7L28_04100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7L28_04105	COG0242	peptide deformylase activity
B7L28_04120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B7L28_04120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L28_04125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B7L28_04130	COG0631	protein serine/threonine phosphatase activity
B7L28_04135	COG2815	serine threonine protein kinase
B7L28_04135	COG0515	serine threonine protein kinase
B7L28_04145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B7L28_04150	COG0052	Belongs to the universal ribosomal protein uS2 family
B7L28_04155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B7L28_04160	COG0528	UMP kinase activity
B7L28_04165	COG0233	cytoplasmic translational termination
B7L28_04175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B7L28_04180	COG4589	Belongs to the CDS family
B7L28_04185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B7L28_04190	COG0750	zinc metalloprotease
B7L28_04195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B7L28_04200	COG0442	prolyl-tRNA aminoacylation
B7L28_04205	COG0613	PHP domain protein
B7L28_04215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L28_04220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B7L28_04225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B7L28_04230	COG2521	methyltransferase
B7L28_04230	COG2136	Putative SAM-dependent methyltransferase
B7L28_04240	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B7L28_04245	COG0482	sulfurtransferase activity
B7L28_04250	COG0481	GTPase activity
B7L28_04255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L28_04265	COG1420	regulation of RNA biosynthetic process
B7L28_04270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B7L28_04280	COG0484	heat shock protein binding
B7L28_04290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L28_04295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L28_04300	COG0537	adenosine 5'-monophosphoramidase activity
B7L28_04310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B7L28_04315	COG0174	glutamine synthetase
B7L28_04325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B7L28_04330	COG1132	(ABC) transporter
B7L28_04335	COG1132	(ABC) transporter
B7L28_04340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L28_04355	COG4492	Belongs to the UPF0735 family
B7L28_04360	COG0460	homoserine dehydrogenase
B7L28_04365	COG0083	homoserine kinase activity
B7L28_04375	COG0105	UTP biosynthetic process
B7L28_04380	COG2096	Adenosyltransferase
B7L28_04395	COG1492	cobalamin metabolic process
B7L28_04415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L28_04420	COG0406	alpha-ribazole phosphatase activity
B7L28_04425	COG1187	pseudouridine synthase activity
B7L28_04430	COG0006	proline dipeptidase activity
B7L28_04435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L28_04455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L28_04465	COG1722	exodeoxyribonuclease VII activity
B7L28_04480	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B7L28_04485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B7L28_04495	COG1438	arginine binding
B7L28_04500	COG0497	DNA recombination
B7L28_04505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B7L28_04510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B7L28_04515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L28_04520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L28_04535	COG2720	vancomycin resistance protein
B7L28_04540	COG0671	phosphoesterase, PA-phosphatase related
B7L28_04570	COG0402	S-adenosylhomocysteine deaminase activity
B7L28_04575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B7L28_04580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B7L28_04585	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B7L28_04590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B7L28_04610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L28_04610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L28_04615	COG0028	Belongs to the TPP enzyme family
B7L28_04640	COG1555	photosystem II stabilization
B7L28_04640	COG1596	polysaccharide export
B7L28_04645	COG2309	aminopeptidase activity
B7L28_04660	COG1388	LysM domain
B7L28_04660	COG3858	chitin binding
B7L28_04665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B7L28_04670	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B7L28_04675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L28_04680	COG0758	DNA mediated transformation
B7L28_04685	COG0606	chelatase, subunit chli
B7L28_04690	COG0792	nuclease activity
B7L28_04705	COG0335	large ribosomal subunit rRNA binding
B7L28_04715	COG0751	glycine-tRNA ligase activity
B7L28_04720	COG0752	glycyl-tRNA synthetase alpha subunit
B7L28_04730	COG3328	transposase activity
B7L28_04765	COG3875	lactate racemase activity
B7L28_04775	COG1691	(AIR) carboxylase
B7L28_04780	COG0482	sulfurtransferase activity
B7L28_04790	COG1253	flavin adenine dinucleotide binding
B7L28_04795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B7L28_04805	COG1702	phosphate starvation-inducible protein PhoH
B7L28_04810	COG1242	4 iron, 4 sulfur cluster binding
B7L28_04825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B7L28_04830	COG0154	amidase activity
B7L28_04840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B7L28_04845	COG0210	DNA helicase
B7L28_04850	COG1227	inorganic diphosphatase activity
B7L28_04870	COG0156	8-amino-7-oxononanoate synthase activity
B7L28_04875	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B7L28_04925	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B7L28_04930	COG0557	exoribonuclease II activity
B7L28_04950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L28_04955	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B7L28_04960	COG0215	cysteine-tRNA ligase activity
B7L28_04965	COG0385	Bile acid
B7L28_04970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L28_04975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B7L28_04975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B7L28_04980	COG4956	integral membrane protein (PIN domain superfamily)
B7L28_04985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B7L28_04990	COG0542	response to heat
B7L28_04995	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B7L28_05000	COG3880	PFAM UvrB UvrC protein
B7L28_05005	COG4463	regulation of RNA biosynthetic process
B7L28_05020	COG0822	iron-sulfur transferase activity
B7L28_05025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B7L28_05040	COG0396	ATPase activity
B7L28_05055	COG0459	protein refolding
B7L28_05060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B7L28_05075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L28_05080	COG0456	acetyltransferase
B7L28_05085	COG1214	PFAM Peptidase M22, glycoprotease
B7L28_05090	COG0802	atpase or kinase
B7L28_05095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B7L28_05110	COG2333	competence protein COMEC
B7L28_05110	COG0658	competence protein
B7L28_05115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L28_05115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B7L28_05120	COG0736	holo-[acyl-carrier-protein] synthase activity
B7L28_05130	COG1943	Transposase
B7L28_05140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B7L28_05150	COG1183	phosphatidylcholine synthase activity
B7L28_05155	COG0688	phosphatidylethanolamine metabolic process
B7L28_05160	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B7L28_05165	COG0517	IMP dehydrogenase activity
B7L28_05165	COG0516	GMP reductase activity
B7L28_05170	COG1942	4-Oxalocrotonate Tautomerase
B7L28_05175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B7L28_05180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B7L28_05185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B7L28_05190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B7L28_05195	COG0517	IMP dehydrogenase activity
B7L28_05200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L28_05200	COG0574	Belongs to the PEP-utilizing enzyme family
B7L28_05240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B7L28_05245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B7L28_05250	COG1193	negative regulation of DNA recombination
B7L28_05255	COG0826	peptidase U32
B7L28_05260	COG0072	phenylalanine-tRNA ligase activity
B7L28_05260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L28_05265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B7L28_05275	COG0577	efflux transmembrane transporter activity
B7L28_05275	COG1136	(ABC) transporter
B7L28_05280	COG1136	(ABC) transporter
B7L28_05295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B7L28_05340	COG2165	general secretion pathway protein
B7L28_05345	COG1459	type II secretion system
B7L28_05350	COG2805	Type II/IV secretion system protein
B7L28_05370	COG0149	triose-phosphate isomerase activity
B7L28_05375	COG0126	phosphoglycerate kinase activity
B7L28_05395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B7L28_05400	COG0698	ribose 5-phosphate isomerase
B7L28_05405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B7L28_05410	COG0009	L-threonylcarbamoyladenylate synthase
B7L28_05415	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L28_05420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B7L28_05425	COG3872	metal-dependent enzyme
B7L28_05430	COG0254	rRNA binding
B7L28_05445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7L28_05465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B7L28_05470	COG3856	small basic protein
B7L28_05485	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L28_05490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L28_05495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L28_05500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B7L28_05505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L28_05510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7L28_05515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B7L28_05520	COG4839	cell division protein FtsL
B7L28_05530	COG2001	Belongs to the MraZ family
B7L28_05540	COG3118	belongs to the thioredoxin family
B7L28_05550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L28_05570	COG2033	superoxide reductase activity
B7L28_05590	COG4822	anaerobic cobalamin biosynthetic process
B7L28_05635	COG1120	ATPase activity
B7L28_05640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_05665	COG2875	Belongs to the precorrin methyltransferase family
B7L28_05680	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B7L28_05685	COG1666	GTP binding
B7L28_05695	COG0564	pseudouridine synthase activity
B7L28_05700	COG0191	fructose-bisphosphate aldolase activity
B7L28_05705	COG2244	polysaccharide biosynthetic process
B7L28_05715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B7L28_05730	COG0546	phosphoglycolate phosphatase activity
B7L28_05800	COG1401	restriction endodeoxyribonuclease activity
B7L28_05865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B7L28_05870	COG0471	metal ion transport
B7L28_05880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B7L28_05910	COG3906	Belongs to the UPF0473 family
B7L28_05915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B7L28_05920	COG4472	Bacterial protein of unknown function (DUF965)
B7L28_05930	COG0791	NLP P60 protein
B7L28_05930	COG1388	LysM domain
B7L28_05935	COG0463	Glycosyl transferase, family 2
B7L28_05945	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B7L28_05975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B7L28_05990	COG0302	gtp cyclohydrolase
B7L28_05995	COG0602	queuosine metabolic process
B7L28_06005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L28_06010	COG0358	DNA primase activity
B7L28_06015	COG1418	mRNA catabolic process
B7L28_06025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B7L28_06030	COG1058	Belongs to the CinA family
B7L28_06030	COG1546	Belongs to the CinA family
B7L28_06035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L28_06070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B7L28_06080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L28_06085	COG0735	belongs to the Fur family
B7L28_06090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L28_06095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L28_06100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7L28_06100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B7L28_06105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L28_06110	COG0390	transport system, permease component
B7L28_06115	COG4619	ABC transporter
B7L28_06120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B7L28_06130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B7L28_06140	COG1530	ribonuclease E activity
B7L28_06155	COG0772	Belongs to the SEDS family
B7L28_06160	COG2894	cell division
B7L28_06165	COG0768	penicillin binding
B7L28_06180	COG1077	Cell shape determining protein MreB Mrl
B7L28_06185	COG2003	Belongs to the UPF0758 family
B7L28_06190	COG0424	maF-like protein
B7L28_06210	COG1323	Belongs to the UPF0348 family
B7L28_06220	COG0564	pseudouridine synthase activity
B7L28_06240	COG0471	metal ion transport
B7L28_06240	COG0490	domain, Protein
B7L28_06250	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B7L28_06255	COG0511	ligase activity, forming carbon-carbon bonds
B7L28_06270	COG0346	lactoylglutathione lyase activity
B7L28_06280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_06280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_06290	COG0427	acetyl-CoA hydrolase
B7L28_06300	COG0285	dihydrofolate synthase activity
B7L28_06305	COG0525	valine-tRNA ligase activity
B7L28_06310	COG0805	protein transport
B7L28_06315	COG0142	geranyltranstransferase activity
B7L28_06325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B7L28_06330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B7L28_06335	COG0740	serine-type endopeptidase activity
B7L28_06340	COG0544	peptidyl-prolyl cis-trans isomerase activity
B7L28_06345	COG0516	GMP reductase activity
B7L28_06345	COG0517	IMP dehydrogenase activity
B7L28_06350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B7L28_06355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B7L28_06360	COG1850	ribulose-bisphosphate carboxylase activity
B7L28_06380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L28_06390	COG1970	mechanosensitive ion channel activity
B7L28_06395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L28_06410	COG2837	iron assimilation
B7L28_06430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B7L28_06440	COG2233	PERMEase
B7L28_06445	COG3404	Formiminotransferase-cyclodeaminase
B7L28_06455	COG0471	metal ion transport
B7L28_06470	COG2207	Transcriptional regulator
B7L28_06485	COG2207	Transcriptional regulator
B7L28_06490	COG0303	'Molybdopterin
B7L28_06500	COG3859	Proton-coupled thiamine transporter YuaJ
B7L28_06510	COG2223	nitrite transmembrane transporter activity
B7L28_06520	COG0519	Catalyzes the synthesis of GMP from XMP
B7L28_06535	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B7L28_06555	COG1332	CRISPR-associated RAMP protein, Csm5 family
B7L28_06560	COG1567	CRISPR-associated RAMP protein, Csm4 family
B7L28_06565	COG1337	RAMP superfamily
B7L28_06575	COG1353	crispr-associated protein
B7L28_06580	COG3069	C4-dicarboxylate transmembrane transporter activity
B7L28_06585	COG1473	amidohydrolase
B7L28_06595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L28_06600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B7L28_06605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B7L28_06615	COG1473	amidohydrolase
B7L28_06620	COG0288	reversible hydration of carbon dioxide
B7L28_06625	COG0440	acetolactate synthase activity
B7L28_06630	COG0028	Belongs to the TPP enzyme family
B7L28_06650	COG2226	methyltransferase
B7L28_06660	COG1704	LemA family
B7L28_06705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L28_06710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B7L28_06715	COG3679	Belongs to the UPF0342 family
B7L28_06720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B7L28_06725	COG0315	cyclic pyranopterin monophosphate synthase activity
B7L28_06730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B7L28_06750	COG0569	domain protein
B7L28_06755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B7L28_06760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L28_06780	COG0848	biopolymer transport protein
B7L28_06785	COG0811	peptide transport
B7L28_06790	COG4771	TonB-dependent receptor
B7L28_06795	COG0662	Cupin 2, conserved barrel domain protein
B7L28_06795	COG2207	Transcriptional regulator
B7L28_06825	COG0488	(ABC) transporter
B7L28_06835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L28_06840	COG0776	regulation of translation
B7L28_06845	COG3956	TIGRFAM MazG family protein
B7L28_06850	COG2244	polysaccharide biosynthetic process
B7L28_06855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B7L28_06915	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B7L28_06925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L28_06930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7L28_06940	COG0419	ATPase involved in DNA repair
B7L28_06945	COG0420	3'-5' exonuclease activity
B7L28_06950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B7L28_06955	COG0735	belongs to the Fur family
B7L28_06960	COG0513	Belongs to the DEAD box helicase family
B7L28_06975	COG3048	D-serine ammonia-lyase activity
B7L28_07005	COG1012	belongs to the aldehyde dehydrogenase family
B7L28_07010	COG2183	response to ionizing radiation
B7L28_07015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B7L28_07020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B7L28_07025	COG0514	ATP-dependent DNA helicase (RecQ)
B7L28_07030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L28_07040	COG4797	methyltransferase
B7L28_07040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L28_07050	COG0583	DNA-binding transcription factor activity
B7L28_07065	COG0670	Belongs to the BI1 family
B7L28_07085	COG2301	Belongs to the HpcH HpaI aldolase family
B7L28_07090	COG3052	prosthetic group binding
B7L28_07095	COG0471	metal ion transport
B7L28_07100	COG0583	DNA-binding transcription factor activity
B7L28_07190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L28_07195	COG0113	porphobilinogen synthase activity
B7L28_07200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L28_07200	COG1587	Uroporphyrinogen-III synthase
B7L28_07205	COG0181	hydroxymethylbilane synthase activity
B7L28_07210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B7L28_07220	COG2302	S4 RNA-binding domain
B7L28_07225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B7L28_07230	COG1799	cell septum assembly
B7L28_07250	COG2323	membrane
B7L28_07265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B7L28_07270	COG1119	ATPase activity
B7L28_07280	COG0028	Belongs to the TPP enzyme family
B7L28_07285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B7L28_07290	COG0129	dihydroxy-acid dehydratase activity
B7L28_07295	COG0471	metal ion transport
B7L28_07310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L28_07315	COG0363	glucosamine-6-phosphate deaminase activity
B7L28_07320	COG1024	Enoyl-CoA hydratase
B7L28_07330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B7L28_07335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B7L28_07340	COG0583	DNA-binding transcription factor activity
B7L28_07345	COG1742	UPF0060 membrane protein
B7L28_07395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L28_07400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L28_07405	COG0287	Prephenate dehydrogenase
B7L28_07410	COG0534	Mate efflux family protein
B7L28_07425	COG1013	pyruvate-flavodoxin oxidoreductase activity
B7L28_07430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B7L28_07430	COG0674	pyruvate-flavodoxin oxidoreductase activity
B7L28_07435	COG0101	tRNA pseudouridine synthase activity
B7L28_07440	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B7L28_07445	COG1122	ATPase activity
B7L28_07450	COG1122	ATPase activity
B7L28_07455	COG0203	ribosomal protein L17
B7L28_07460	COG0202	RNA polymerase activity
B7L28_07475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B7L28_07495	COG0201	protein transport
B7L28_07500	COG0200	Binds to the 23S rRNA
B7L28_07505	COG1841	ribosomal large subunit assembly
B7L28_07510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B7L28_07515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B7L28_07520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B7L28_07525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B7L28_07530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B7L28_07535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B7L28_07545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B7L28_07560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B7L28_07565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B7L28_07570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B7L28_07575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B7L28_07580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B7L28_07585	COG0089	rRNA binding
B7L28_07590	COG0088	Forms part of the polypeptide exit tunnel
B7L28_07595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B7L28_07600	COG0051	transcription antitermination factor activity, RNA binding
B7L28_07605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L28_07615	COG0049	tRNA binding
B7L28_07620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B7L28_07630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B7L28_07635	COG0085	RNA polymerase activity
B7L28_07640	COG1027	Aspartate ammonia-lyase
B7L28_07645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B7L28_07650	COG0222	ribosome binding
B7L28_07660	COG0081	regulation of translation
B7L28_07665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B7L28_07670	COG0250	Participates in transcription elongation, termination and antitermination
B7L28_07675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B7L28_07695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L28_07735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B7L28_07745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B7L28_07750	COG0768	penicillin binding
B7L28_07755	COG0617	tRNA 3'-terminal CCA addition
B7L28_07760	COG1760	l-serine dehydratase
B7L28_07765	COG1760	l-serine dehydratase
B7L28_07770	COG1151	hydroxylamine reductase activity
B7L28_07795	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B7L28_07820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B7L28_07835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B7L28_07840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L28_07845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B7L28_07850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L28_07855	COG0356	it plays a direct role in the translocation of protons across the membrane
B7L28_07870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B7L28_07875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L28_07880	COG2848	UPF0210 protein
B7L28_07885	COG3830	Belongs to the UPF0237 family
B7L28_07890	COG0033	Phosphoglucomutase
B7L28_07895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B7L28_07900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B7L28_07905	COG1802	Transcriptional regulator
B7L28_07910	COG1115	amino acid carrier protein
B7L28_07915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B7L28_07925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B7L28_07930	COG0708	Exodeoxyribonuclease III
B7L28_07975	COG1943	Transposase
B7L28_07980	COG0747	negative chemotaxis
B7L28_07990	COG0444	Belongs to the ABC transporter superfamily
B7L28_07995	COG0747	negative chemotaxis
B7L28_08005	COG0601	transmembrane transport
B7L28_08010	COG4608	Belongs to the ABC transporter superfamily
B7L28_08015	COG0444	Belongs to the ABC transporter superfamily
B7L28_08020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L28_08030	COG0747	negative chemotaxis
B7L28_08045	COG4139	cobalamin transport
B7L28_08050	COG1120	ATPase activity
B7L28_08055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_08060	COG4774	siderophore transport
B7L28_08080	COG0531	amino acid
B7L28_08085	COG0165	Argininosuccinate lyase
B7L28_08090	COG0137	argininosuccinate synthase activity
B7L28_08095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L28_08105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L28_08110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L28_08115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B7L28_08120	COG1757	Na H antiporter
B7L28_08125	COG1105	Belongs to the carbohydrate kinase PfkB family
B7L28_08130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L28_08130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L28_08130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L28_08135	COG1943	Transposase
B7L28_08165	COG0450	alkyl hydroperoxide reductase
B7L28_08175	COG0504	CTP synthase activity
B7L28_08180	COG0018	arginyl-trna synthetase
B7L28_08200	COG0561	phosphatase activity
B7L28_08210	COG1114	Component of the transport system for branched-chain amino acids
B7L28_08215	COG0243	molybdopterin cofactor binding
B7L28_08220	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B7L28_08225	COG1620	l-lactate permease
B7L28_08230	COG2814	Major facilitator Superfamily
B7L28_08240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B7L28_08255	COG0494	nUDIX hydrolase
B7L28_08275	COG1454	alcohol dehydrogenase
B7L28_08290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L28_08295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L28_08310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B7L28_08315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B7L28_08320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B7L28_08325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B7L28_08330	COG1605	Chorismate mutase
B7L28_08330	COG0077	Prephenate dehydratase
B7L28_08350	COG0710	3-dehydroquinate dehydratase activity
B7L28_08355	COG2814	Major facilitator Superfamily
B7L28_08360	COG1959	2 iron, 2 sulfur cluster binding
B7L28_08365	COG2252	PERMEase
B7L28_08385	COG1113	amino acid transport
B7L28_08400	COG0564	pseudouridine synthase activity
B7L28_08420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B7L28_08425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B7L28_08435	COG0067	glutamate synthase
B7L28_08435	COG0069	glutamate synthase activity
B7L28_08435	COG0070	glutamate synthase
B7L28_08455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B7L28_08460	COG4717	serine-type aminopeptidase activity
B7L28_08465	COG0420	3'-5' exonuclease activity
B7L28_08470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L28_08475	COG0564	pseudouridine synthase activity
B7L28_08495	COG0656	L-ascorbic acid biosynthetic process
B7L28_08500	COG1687	branched-chain amino acid
B7L28_08505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B7L28_08510	COG1979	alcohol dehydrogenase
B7L28_08520	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B7L28_08520	COG0778	Nitroreductase
B7L28_08525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L28_08525	COG2146	nitrite reductase [NAD(P)H] activity
B7L28_08535	COG1556	Lactate utilization protein
B7L28_08540	COG1139	Iron-sulfur cluster binding protein
B7L28_08545	COG0247	lactate metabolic process
B7L28_08570	COG1297	OPT oligopeptide transporter protein
B7L28_08580	COG1408	metallophosphoesterase
B7L28_08590	COG1051	belongs to the nudix hydrolase family
B7L28_08635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B7L28_08650	COG1597	lipid kinase activity
B7L28_08655	COG1074	ATP-dependent DNA helicase activity
B7L28_08660	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B7L28_08695	COG2217	Heavy metal translocating P-type atpase
B7L28_08705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L28_08710	COG0305	Participates in initiation and elongation during chromosome replication
B7L28_08720	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B7L28_08730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B7L28_08735	COG3152	Membrane
B7L28_08745	COG1116	anion transmembrane transporter activity
B7L28_08745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L28_08750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L28_08760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B7L28_08765	COG0586	Pfam SNARE associated Golgi protein
B7L28_08775	COG2048	Heterodisulfide reductase, subunit B
B7L28_08780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7L28_08785	COG1053	succinate dehydrogenase
B7L28_08790	COG0745	RESPONSE REGULATOR receiver
B7L28_08795	COG3850	Histidine kinase
B7L28_08795	COG5002	protein histidine kinase activity
B7L28_08800	COG2733	membrane
B7L28_08805	COG2733	membrane
B7L28_08815	COG1733	regulation of RNA biosynthetic process
B7L28_08820	COG2910	NAD(P)H-binding
B7L28_08835	COG0280	phosphate acetyltransferase
B7L28_08840	COG1373	ATPase (AAA superfamily
B7L28_08855	COG0493	'glutamate synthase
B7L28_08870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B7L28_08880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B7L28_08885	COG2824	Alkylphosphonate utilization operon protein PhnA
B7L28_08890	COG0789	Transcriptional regulator
B7L28_08975	COG3866	Pectate lyase
B7L28_08995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B7L28_09005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B7L28_09020	COG0848	biopolymer transport protein
B7L28_09025	COG0811	peptide transport
B7L28_09035	COG1703	isobutyryl-CoA mutase activity
B7L28_09040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_09040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_09045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_09045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_09075	COG0277	FAD linked oxidase domain protein
B7L28_09085	COG3041	Addiction module toxin RelE StbE family
B7L28_09095	COG3875	lactate racemase activity
B7L28_09105	COG1454	alcohol dehydrogenase
B7L28_09110	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L28_09120	COG1994	Peptidase M50
B7L28_09135	COG1846	Transcriptional regulator
B7L28_09165	COG1393	Belongs to the ArsC family
B7L28_09225	COG1943	Transposase
B7L28_09240	COG3152	Membrane
B7L28_09275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B7L28_09280	COG2271	Major facilitator Superfamily
B7L28_09310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L28_09360	COG0739	heme binding
B7L28_09360	COG0741	lytic transglycosylase activity
B7L28_09360	COG1196	nuclear chromosome segregation
B7L28_09370	COG1160	GTP binding
B7L28_09375	COG1475	DNA binding
B7L28_09380	COG1192	Involved in chromosome partitioning
B7L28_09395	COG0646	methionine synthase
B7L28_09395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L28_09400	COG0357	Ribosomal RNA small subunit methyltransferase G
B7L28_09405	COG0445	tRNA wobble uridine modification
B7L28_09415	COG1847	R3H domain protein
B7L28_09420	COG0706	membrane insertase activity
B7L28_09425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B7L28_09430	COG0594	ribonuclease P activity
B7L28_09435	COG0230	Belongs to the bacterial ribosomal protein bL34 family