locus-tag	class	description
Vpar_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vpar_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Vpar_0007	COG0187	DNA topoisomerase II activity
Vpar_0008	COG0833	amino acid
Vpar_0011	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vpar_0012	COG1253	flavin adenine dinucleotide binding
Vpar_0016	COG1216	Glycosyl transferase, family 2
Vpar_0016	COG1442	glycosyl transferase family 8
Vpar_0017	COG0463	Glycosyl transferase, family 2
Vpar_0022	COG3594	Acyltransferase
Vpar_0023	COG0562	UDP-galactopyranose mutase
Vpar_0027	COG0438	transferase activity, transferring glycosyl groups
Vpar_0028	COG0726	polysaccharide deacetylase
Vpar_0029	COG3475	LICD family
Vpar_0030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Vpar_0032	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vpar_0041	COG0497	DNA recombination
Vpar_0058	COG0811	peptide transport
Vpar_0059	COG0848	biopolymer transport protein
Vpar_0061	COG4771	TonB-dependent receptor
Vpar_0063	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vpar_0065	COG4206	TonB-dependent receptor
Vpar_0067	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Vpar_0068	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vpar_0069	COG1120	ATPase activity
Vpar_0074	COG4206	TonB-dependent receptor
Vpar_0075	COG0436	Aminotransferase
Vpar_0076	COG0640	Transcriptional regulator
Vpar_0078	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Vpar_0081	COG4221	oxidoreductase activity
Vpar_0086	COG0747	negative chemotaxis
Vpar_0087	COG0444	Belongs to the ABC transporter superfamily
Vpar_0088	COG4608	Belongs to the ABC transporter superfamily
Vpar_0094	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vpar_0096	COG0066	3-isopropylmalate dehydratase activity
Vpar_0097	COG0473	3-isopropylmalate dehydrogenase activity
Vpar_0100	COG1196	nuclear chromosome segregation
Vpar_0105	COG1879	ABC-type sugar transport system periplasmic component
Vpar_0106	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vpar_0107	COG1129	ABC transporter
Vpar_0108	COG1869	D-ribose catabolic process
Vpar_0109	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vpar_0116	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Vpar_0118	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Vpar_0119	COG1122	ATPase activity
Vpar_0120	COG1122	ATPase activity
Vpar_0123	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Vpar_0125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vpar_0126	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Vpar_0127	COG0131	Imidazoleglycerol-phosphate dehydratase
Vpar_0128	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vpar_0129	COG0107	imidazoleglycerol-phosphate synthase activity
Vpar_0130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vpar_0132	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vpar_0133	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Vpar_0134	COG1966	Carbon starvation protein
Vpar_0139	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vpar_0141	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Vpar_0142	COG1045	serine acetyltransferase
Vpar_0145	COG1914	H( )-stimulated, divalent metal cation uptake system
Vpar_0147	COG3022	response to hydroperoxide
Vpar_0148	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Vpar_0149	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vpar_0150	COG2731	YhcH YjgK YiaL family protein
Vpar_0151	COG0697	spore germination
Vpar_0155	COG3069	C4-dicarboxylate transmembrane transporter activity
Vpar_0159	COG0512	Glutamine amidotransferase of anthranilate synthase
Vpar_0159	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vpar_0162	COG0133	tryptophan synthase activity
Vpar_0163	COG0159	tryptophan synthase activity
Vpar_0166	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vpar_0171	COG1132	(ABC) transporter
Vpar_0172	COG0535	radical SAM domain protein
Vpar_0174	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vpar_0176	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vpar_0178	COG0561	phosphatase activity
Vpar_0180	COG0656	L-ascorbic acid biosynthetic process
Vpar_0181	COG0519	Catalyzes the synthesis of GMP from XMP
Vpar_0181	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vpar_0197	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vpar_0198	COG1120	ATPase activity
Vpar_0199	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vpar_0200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vpar_0201	COG1121	(ABC) transporter
Vpar_0202	COG0803	Belongs to the bacterial solute-binding protein 9 family
Vpar_0208	COG0583	DNA-binding transcription factor activity
Vpar_0209	COG1151	hydroxylamine reductase activity
Vpar_0210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Vpar_0213	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Vpar_0214	COG0420	3'-5' exonuclease activity
Vpar_0215	COG4717	serine-type aminopeptidase activity
Vpar_0216	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Vpar_0220	COG2223	nitrite transmembrane transporter activity
Vpar_0221	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vpar_0222	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Vpar_0223	COG1140	nitrate reductase beta subunit
Vpar_0224	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Vpar_0225	COG2181	nitrate reductase activity
Vpar_0227	COG3206	protein involved in exopolysaccharide biosynthesis
Vpar_0229	COG2814	Major facilitator Superfamily
Vpar_0230	COG0583	DNA-binding transcription factor activity
Vpar_0232	COG2855	membrane
Vpar_0233	COG0288	reversible hydration of carbon dioxide
Vpar_0235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vpar_0236	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vpar_0238	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vpar_0239	COG1121	(ABC) transporter
Vpar_0240	COG0803	Belongs to the bacterial solute-binding protein 9 family
Vpar_0249	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vpar_0250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vpar_0252	COG2217	Heavy metal translocating P-type atpase
Vpar_0253	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vpar_0254	COG1882	Formate acetyltransferase
Vpar_0259	COG2011	ABC-type metal ion transport system permease component
Vpar_0263	COG0471	metal ion transport
Vpar_0266	COG0626	cystathionine gamma-synthase activity
Vpar_0267	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Vpar_0268	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Vpar_0273	COG0701	Predicted permease
Vpar_0274	COG0523	cobalamin synthesis protein
Vpar_0275	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vpar_0276	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Vpar_0278	COG0252	asparaginase activity
Vpar_0280	COG0668	transmembrane transport
Vpar_0281	COG1686	Belongs to the peptidase S11 family
Vpar_0283	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Vpar_0285	COG2080	2 iron, 2 sulfur cluster binding
Vpar_0286	COG2080	2 iron, 2 sulfur cluster binding
Vpar_0286	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vpar_0290	COG3608	succinylglutamate desuccinylase aspartoacylase
Vpar_0290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Vpar_0292	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Vpar_0293	COG4856	YbbR-like protein
Vpar_0294	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Vpar_0295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vpar_0296	COG1794	racemase activity, acting on amino acids and derivatives
Vpar_0299	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Vpar_0300	COG0180	Tryptophanyl-tRNA synthetase
Vpar_0303	COG0765	amino acid transport
Vpar_0304	COG1126	abc transporter atp-binding protein
Vpar_0306	COG0589	response to stress
Vpar_0307	COG0640	Transcriptional regulator
Vpar_0309	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vpar_0310	COG4149	molybdate abc transporter
Vpar_0311	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Vpar_0316	COG1592	Rubrerythrin
Vpar_0318	COG0709	Synthesizes selenophosphate from selenide and ATP
Vpar_0321	COG0778	Nitroreductase
Vpar_0322	COG2261	transglycosylase associated protein
Vpar_0324	COG0012	GTP binding
Vpar_0325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vpar_0335	COG2814	Major facilitator Superfamily
Vpar_0336	COG0360	Binds together with S18 to 16S ribosomal RNA
Vpar_0337	COG0629	single-stranded DNA binding
Vpar_0338	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Vpar_0341	COG1433	Dinitrogenase iron-molybdenum cofactor
Vpar_0341	COG0535	radical SAM domain protein
Vpar_0342	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vpar_0346	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Vpar_0347	COG0772	Belongs to the SEDS family
Vpar_0350	COG4864	UPF0365 protein
Vpar_0356	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vpar_0357	COG1297	OPT oligopeptide transporter protein
Vpar_0359	COG2040	homocysteine
Vpar_0360	COG0426	domain, Protein
Vpar_0361	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vpar_0362	COG0583	DNA-binding transcription factor activity
Vpar_0363	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vpar_0366	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vpar_0368	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vpar_0369	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vpar_0370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Vpar_0372	COG0151	Belongs to the GarS family
Vpar_0373	COG1169	isochorismate synthase
Vpar_0374	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Vpar_0375	COG0596	Alpha beta hydrolase
Vpar_0376	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Vpar_0377	COG0318	PFAM AMP-dependent synthetase and ligase
Vpar_0382	COG1396	sequence-specific DNA binding
Vpar_0390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vpar_0391	COG1649	PFAM Uncharacterised BCR, COG1649
Vpar_0391	COG0726	polysaccharide deacetylase
Vpar_0392	COG4632	Exopolysaccharide biosynthesis protein
Vpar_0392	COG5434	Belongs to the glycosyl hydrolase 28 family
Vpar_0399	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vpar_0404	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vpar_0405	COG0284	orotidine-5'-phosphate decarboxylase activity
Vpar_0410	COG1464	Belongs to the NlpA lipoprotein family
Vpar_0411	COG1575	Belongs to the MenA family. Type 1 subfamily
Vpar_0414	COG0251	oxidation-reduction process
Vpar_0415	COG3681	Belongs to the UPF0597 family
Vpar_0416	COG2223	nitrite transmembrane transporter activity
Vpar_0417	COG0590	tRNA wobble adenosine to inosine editing
Vpar_0422	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Vpar_0423	COG2011	ABC-type metal ion transport system permease component
Vpar_0424	COG4496	protein, YerC YecD
Vpar_0426	COG1028	Short-chain dehydrogenase reductase Sdr
Vpar_0428	COG3339	Conserved Protein
Vpar_0429	COG0824	Thioesterase
Vpar_0430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Vpar_0433	COG0145	ligase activity
Vpar_0435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Vpar_0436	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vpar_0438	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vpar_0439	COG0281	malic enzyme
Vpar_0442	COG4974	Belongs to the 'phage' integrase family
Vpar_0447	COG1396	sequence-specific DNA binding
Vpar_0450	COG5295	Hep Hag repeat protein
Vpar_0450	COG5295	Hep Hag repeat protein
Vpar_0454	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Vpar_0458	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vpar_0459	COG0352	thiamine-phosphate diphosphorylase activity
Vpar_0460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Vpar_0461	COG1914	H( )-stimulated, divalent metal cation uptake system
Vpar_0462	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Vpar_0463	COG1984	allophanate hydrolase subunit 2
Vpar_0465	COG0534	Mate efflux family protein
Vpar_0467	COG2885	chlorophyll binding
Vpar_0468	COG0628	permease
Vpar_0470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vpar_0471	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Vpar_0472	COG2226	methyltransferase
Vpar_0474	COG0726	polysaccharide deacetylase
Vpar_0475	COG0521	Mo-molybdopterin cofactor biosynthetic process
Vpar_0476	COG1959	2 iron, 2 sulfur cluster binding
Vpar_0477	COG1271	oxidase subunit
Vpar_0478	COG1294	oxidase, subunit
Vpar_0479	COG4988	ABC transporter
Vpar_0484	COG0601	transmembrane transport
Vpar_0485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vpar_0486	COG0444	Belongs to the ABC transporter superfamily
Vpar_0487	COG4608	Belongs to the ABC transporter superfamily
Vpar_0489	COG4166	transmembrane transport
Vpar_0490	COG1619	proteins homologs of microcin C7 resistance protein MccF
Vpar_0492	COG0488	(ABC) transporter
Vpar_0494	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Vpar_0496	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Vpar_0496	COG0302	gtp cyclohydrolase
Vpar_0498	COG0039	L-malate dehydrogenase activity
Vpar_0500	COG1098	S1 RNA binding domain
Vpar_0502	COG0037	tRNA processing
Vpar_0503	COG0037	tRNA processing
Vpar_0503	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Vpar_0504	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vpar_0507	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Vpar_0508	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vpar_0509	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vpar_0510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Vpar_0511	COG2252	PERMEase
Vpar_0512	COG0402	S-adenosylhomocysteine deaminase activity
Vpar_0515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Vpar_0516	COG1494	fructose-1,6-bisphosphatase
Vpar_0517	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Vpar_0522	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Vpar_0523	COG1127	ABC transporter
Vpar_0531	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vpar_0532	COG1560	Kdo2-lipid A biosynthetic process
Vpar_0533	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Vpar_0534	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vpar_0538	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vpar_0539	COG1132	(ABC) transporter
Vpar_0540	COG1519	Transferase
Vpar_0541	COG1663	tetraacyldisaccharide 4'-kinase activity
Vpar_0542	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Vpar_0543	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Vpar_0545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Vpar_0548	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Vpar_0549	COG1137	ATPase activity
Vpar_0551	COG4372	Transposase
Vpar_0553	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Vpar_0555	COG0497	DNA recombination
Vpar_0556	COG0497	DNA recombination
Vpar_0557	COG0497	DNA recombination
Vpar_0560	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Vpar_0561	COG1481	regulation of sporulation
Vpar_0563	COG0540	Belongs to the ATCase OTCase family
Vpar_0564	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Vpar_0567	COG0543	2 iron, 2 sulfur cluster binding
Vpar_0568	COG0167	dihydroorotate dehydrogenase activity
Vpar_0569	COG0583	DNA-binding transcription factor activity
Vpar_0571	COG1739	Uncharacterized protein family UPF0029
Vpar_0572	COG2217	Heavy metal translocating P-type atpase
Vpar_0574	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vpar_0575	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Vpar_0576	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vpar_0580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Vpar_0581	COG0336	Belongs to the RNA methyltransferase TrmD family
Vpar_0588	COG4752	Belongs to the RNA methyltransferase TrmD family
Vpar_0589	COG0217	transcriptional regulatory protein
Vpar_0590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Vpar_0591	COG0632	four-way junction helicase activity
Vpar_0593	COG2247	cell wall binding repeat
Vpar_0593	COG2385	sporulation resulting in formation of a cellular spore
Vpar_0595	COG0343	queuine tRNA-ribosyltransferase activity
Vpar_0598	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vpar_0599	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vpar_0600	COG2814	Major facilitator Superfamily
Vpar_0601	COG3585	molybdate ion transport
Vpar_0603	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vpar_0604	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vpar_0605	COG3584	3D domain protein
Vpar_0605	COG3583	domain protein
Vpar_0606	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vpar_0607	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Vpar_0609	COG0193	aminoacyl-tRNA hydrolase activity
Vpar_0610	COG1982	Orn Lys Arg decarboxylase major
Vpar_0611	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vpar_0612	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Vpar_0613	COG1774	PSP1 C-terminal conserved region
Vpar_0614	COG2264	protein methyltransferase activity
Vpar_0615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Vpar_0616	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vpar_0616	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vpar_0617	COG0084	hydrolase, TatD family'
Vpar_0620	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Vpar_0621	COG1388	LysM domain
Vpar_0621	COG3584	3D domain protein
Vpar_0623	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vpar_0624	COG0583	DNA-binding transcription factor activity
Vpar_0625	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Vpar_0626	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Vpar_0627	COG0786	glutamate:sodium symporter activity
Vpar_0628	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Vpar_0629	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vpar_0632	COG1918	ferrous iron import across plasma membrane
Vpar_0632	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Vpar_0640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Vpar_0641	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Vpar_0642	COG0298	carbon dioxide binding
Vpar_0650	COG1268	BioY protein
Vpar_0652	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vpar_0654	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Vpar_0655	COG0328	RNA-DNA hybrid ribonuclease activity
Vpar_0655	COG3341	Caulimovirus viroplasmin
Vpar_0656	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vpar_0658	COG0166	Belongs to the GPI family
Vpar_0659	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vpar_0662	COG0488	(ABC) transporter
Vpar_0664	COG0559	Belongs to the binding-protein-dependent transport system permease family
Vpar_0667	COG0410	ABC transporter
Vpar_0671	COG3206	protein involved in exopolysaccharide biosynthesis
Vpar_0671	COG0489	protein tyrosine kinase activity
Vpar_0672	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Vpar_0673	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vpar_0674	COG3475	LICD family
Vpar_0675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Vpar_0676	COG1086	Polysaccharide biosynthesis protein
Vpar_0677	COG0438	transferase activity, transferring glycosyl groups
Vpar_0686	COG1328	CTP reductase activity
Vpar_0687	COG0602	queuosine metabolic process
Vpar_0691	COG1773	rubredoxin
Vpar_0693	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Vpar_0694	COG2030	dehydratase
Vpar_0696	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vpar_0698	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Vpar_0699	COG1028	Short-chain dehydrogenase reductase Sdr
Vpar_0700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vpar_0701	COG2070	2-Nitropropane dioxygenase
Vpar_0702	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vpar_0703	COG0571	ribonuclease III activity
Vpar_0704	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vpar_0705	COG1196	nuclear chromosome segregation
Vpar_0706	COG0552	protein localization to endoplasmic reticulum
Vpar_0708	COG0556	nucleotide-excision repair
Vpar_0709	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Vpar_0710	COG0322	excinuclease ABC activity
Vpar_0711	COG0534	Mate efflux family protein
Vpar_0712	COG0861	Integral membrane protein TerC family
Vpar_0713	COG0861	Integral membrane protein TerC family
Vpar_0714	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vpar_0719	COG4771	TonB-dependent receptor
Vpar_0721	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vpar_0744	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vpar_0745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Vpar_0748	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vpar_0750	COG0471	metal ion transport
Vpar_0751	COG1362	aminopeptidase activity
Vpar_0752	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Vpar_0753	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Vpar_0755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vpar_0756	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Vpar_0756	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Vpar_0757	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vpar_0758	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vpar_0759	COG0859	PFAM glycosyl transferase family 9
Vpar_0761	COG2176	DNA-directed DNA polymerase activity
Vpar_0762	COG1362	aminopeptidase activity
Vpar_0766	COG4120	Belongs to the binding-protein-dependent transport system permease family
Vpar_0768	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Vpar_0769	COG1185	polyribonucleotide nucleotidyltransferase activity
Vpar_0770	COG0756	dUTP diphosphatase activity
Vpar_0771	COG4797	methyltransferase
Vpar_0771	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vpar_0774	COG2252	PERMEase
Vpar_0777	COG0268	Binds directly to 16S ribosomal RNA
Vpar_0779	COG0237	dephospho-CoA kinase activity
Vpar_0780	COG0741	lytic transglycosylase activity
Vpar_0783	COG0195	Participates in both transcription termination and antitermination
Vpar_0785	COG1358	cellular component organization or biogenesis
Vpar_0786	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vpar_0786	COG3170	Tfp pilus assembly protein FimV
Vpar_0787	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Vpar_0788	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Vpar_0790	COG0196	riboflavin kinase activity
Vpar_0792	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Vpar_0793	COG1040	competence protein
Vpar_0795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vpar_0796	COG0765	amino acid transport
Vpar_0798	COG1278	Cold shock
Vpar_0800	COG0653	protein targeting
Vpar_0805	COG3959	Transketolase, thiamine diphosphate binding domain
Vpar_0806	COG3958	Transketolase
Vpar_0807	COG2884	Cell division ATP-binding protein ftsE
Vpar_0808	COG2177	Part of the ABC transporter FtsEX involved in
Vpar_0809	COG0739	heme binding
Vpar_0810	COG0793	Belongs to the peptidase S41A family
Vpar_0811	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vpar_0813	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Vpar_0814	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Vpar_0815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Vpar_0816	COG1713	HD superfamily hydrolase involved in NAD metabolism
Vpar_0818	COG0799	negative regulation of ribosome biogenesis
Vpar_0819	COG2996	Protein conserved in bacteria
Vpar_0820	COG0569	domain protein
Vpar_0821	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vpar_0822	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vpar_0823	COG1683	Conserved Protein
Vpar_0825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Vpar_0826	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Vpar_0827	COG1187	pseudouridine synthase activity
Vpar_0828	COG2081	HI0933 family
Vpar_0829	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Vpar_0831	COG0539	negative regulation of cytoplasmic translation
Vpar_0831	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Vpar_0833	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Vpar_0834	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Vpar_0835	COG0742	ribosomal rna small subunit methyltransferase
Vpar_0836	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Vpar_0839	COG1561	YicC-like family, N-terminal region
Vpar_0840	COG2052	Domain of unknown function (DUF370)
Vpar_0841	COG0194	GDP metabolic process
Vpar_0842	COG1758	RNA polymerase activity
Vpar_0843	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vpar_0844	COG0659	secondary active sulfate transmembrane transporter activity
Vpar_0845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Vpar_0846	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Vpar_0847	COG0242	peptide deformylase activity
Vpar_0848	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Vpar_0850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vpar_0850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vpar_0851	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Vpar_0852	COG0631	protein serine/threonine phosphatase activity
Vpar_0853	COG0515	serine threonine protein kinase
Vpar_0853	COG2815	serine threonine protein kinase
Vpar_0854	COG1162	GTPase activity
Vpar_0855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Vpar_0856	COG0052	Belongs to the universal ribosomal protein uS2 family
Vpar_0857	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Vpar_0858	COG0528	UMP kinase activity
Vpar_0859	COG0233	cytoplasmic translational termination
Vpar_0862	COG4589	Belongs to the CDS family
Vpar_0863	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Vpar_0864	COG0750	zinc metalloprotease
Vpar_0865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Vpar_0866	COG0442	prolyl-tRNA aminoacylation
Vpar_0867	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Vpar_0867	COG1796	DNA polymerase
Vpar_0872	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Vpar_0873	COG2521	methyltransferase
Vpar_0873	COG2136	Putative SAM-dependent methyltransferase
Vpar_0875	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Vpar_0876	COG0482	sulfurtransferase activity
Vpar_0877	COG0481	GTPase activity
Vpar_0878	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vpar_0882	COG0443	Heat shock 70 kDa protein
Vpar_0883	COG0484	heat shock protein binding
Vpar_0884	COG2264	protein methyltransferase activity
Vpar_0885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Vpar_0886	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vpar_0887	COG0537	adenosine 5'-monophosphoramidase activity
Vpar_0889	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Vpar_0890	COG0174	glutamine synthetase
Vpar_0892	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Vpar_0893	COG1132	(ABC) transporter
Vpar_0894	COG1132	(ABC) transporter
Vpar_0895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vpar_0896	COG3394	polysaccharide catabolic process
Vpar_0898	COG4492	Belongs to the UPF0735 family
Vpar_0899	COG0460	homoserine dehydrogenase
Vpar_0900	COG0083	homoserine kinase activity
Vpar_0902	COG0105	UTP biosynthetic process
Vpar_0905	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Vpar_0906	COG1492	cobalamin metabolic process
Vpar_0911	COG0406	alpha-ribazole phosphatase activity
Vpar_0912	COG1187	pseudouridine synthase activity
Vpar_0913	COG0006	proline dipeptidase activity
Vpar_0914	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Vpar_0917	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vpar_0918	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vpar_0920	COG1722	exodeoxyribonuclease VII activity
Vpar_0923	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Vpar_0924	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vpar_0926	COG1438	arginine binding
Vpar_0927	COG0497	DNA recombination
Vpar_0928	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Vpar_0929	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vpar_0930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vpar_0933	COG0385	Bile acid
Vpar_0934	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Vpar_0937	COG2720	vancomycin resistance protein
Vpar_0946	COG0402	S-adenosylhomocysteine deaminase activity
Vpar_0947	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Vpar_0948	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Vpar_0949	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Vpar_0950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Vpar_0952	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vpar_0952	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vpar_0954	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vpar_0954	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vpar_0955	COG0028	Belongs to the TPP enzyme family
Vpar_0961	COG1555	photosystem II stabilization
Vpar_0962	COG2309	aminopeptidase activity
Vpar_0965	COG3858	chitin binding
Vpar_0965	COG1388	LysM domain
Vpar_0966	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Vpar_0967	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Vpar_0968	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vpar_0969	COG0758	DNA mediated transformation
Vpar_0970	COG0606	chelatase, subunit chli
Vpar_0971	COG0792	nuclease activity
Vpar_0976	COG0751	glycine-tRNA ligase activity
Vpar_0977	COG0752	glycyl-tRNA synthetase alpha subunit
Vpar_0979	COG3210	domain, Protein
Vpar_0984	COG3875	lactate racemase activity
Vpar_0986	COG1691	(AIR) carboxylase
Vpar_0989	COG1253	flavin adenine dinucleotide binding
Vpar_0990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Vpar_0992	COG1702	phosphate starvation-inducible protein PhoH
Vpar_0993	COG1242	4 iron, 4 sulfur cluster binding
Vpar_0996	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Vpar_0997	COG0154	amidase activity
Vpar_0999	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Vpar_1000	COG0210	DNA helicase
Vpar_1001	COG1227	inorganic diphosphatase activity
Vpar_1006	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
Vpar_1008	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Vpar_1009	COG0557	exoribonuclease II activity
Vpar_1010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vpar_1013	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vpar_1014	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Vpar_1015	COG0215	cysteine-tRNA ligase activity
Vpar_1016	COG0385	Bile acid
Vpar_1017	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vpar_1018	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Vpar_1018	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Vpar_1019	COG4956	integral membrane protein (PIN domain superfamily)
Vpar_1020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Vpar_1021	COG0542	response to heat
Vpar_1022	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Vpar_1023	COG3880	PFAM UvrB UvrC protein
Vpar_1024	COG4463	regulation of RNA biosynthetic process
Vpar_1025	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vpar_1027	COG0822	iron-sulfur transferase activity
Vpar_1028	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vpar_1031	COG0396	ATPase activity
Vpar_1034	COG0459	protein refolding
Vpar_1035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Vpar_1039	COG0456	acetyltransferase
Vpar_1040	COG1214	PFAM Peptidase M22, glycoprotease
Vpar_1041	COG0802	atpase or kinase
Vpar_1042	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Vpar_1044	COG0860	N-Acetylmuramoyl-L-alanine amidase
Vpar_1045	COG2333	competence protein COMEC
Vpar_1045	COG0658	competence protein
Vpar_1046	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Vpar_1046	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Vpar_1047	COG0736	holo-[acyl-carrier-protein] synthase activity
Vpar_1049	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vpar_1052	COG0688	phosphatidylethanolamine metabolic process
Vpar_1053	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Vpar_1054	COG0517	IMP dehydrogenase activity
Vpar_1054	COG0516	GMP reductase activity
Vpar_1055	COG1942	4-Oxalocrotonate Tautomerase
Vpar_1056	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Vpar_1057	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Vpar_1058	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Vpar_1059	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Vpar_1060	COG0517	IMP dehydrogenase activity
Vpar_1061	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vpar_1061	COG0574	Belongs to the PEP-utilizing enzyme family
Vpar_1063	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Vpar_1064	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Vpar_1065	COG1193	negative regulation of DNA recombination
Vpar_1066	COG0826	peptidase U32
Vpar_1067	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vpar_1067	COG0072	phenylalanine-tRNA ligase activity
Vpar_1068	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Vpar_1070	COG0577	efflux transmembrane transporter activity
Vpar_1070	COG1136	(ABC) transporter
Vpar_1071	COG1136	(ABC) transporter
Vpar_1072	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vpar_1074	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Vpar_1083	COG1459	type II secretion system
Vpar_1084	COG2805	Type II/IV secretion system protein
Vpar_1085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vpar_1088	COG0149	triose-phosphate isomerase activity
Vpar_1089	COG0126	phosphoglycerate kinase activity
Vpar_1093	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vpar_1094	COG0698	ribose 5-phosphate isomerase
Vpar_1095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Vpar_1096	COG0009	L-threonylcarbamoyladenylate synthase
Vpar_1097	COG2890	protein-(glutamine-N5) methyltransferase activity
Vpar_1098	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Vpar_1099	COG3872	metal-dependent enzyme
Vpar_1100	COG0254	rRNA binding
Vpar_1103	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vpar_1107	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Vpar_1111	COG1181	Belongs to the D-alanine--D-alanine ligase family
Vpar_1112	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vpar_1114	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Vpar_1115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Vpar_1116	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Vpar_1117	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Vpar_1119	COG0275	rRNA processing
Vpar_1120	COG2001	Belongs to the MraZ family
Vpar_1121	COG3118	belongs to the thioredoxin family
Vpar_1123	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vpar_1127	COG2033	superoxide reductase activity
Vpar_1131	COG4822	anaerobic cobalamin biosynthetic process
Vpar_1137	COG1120	ATPase activity
Vpar_1138	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vpar_1143	COG2875	Belongs to the precorrin methyltransferase family
Vpar_1146	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Vpar_1147	COG1666	GTP binding
Vpar_1149	COG0564	pseudouridine synthase activity
Vpar_1150	COG0191	fructose-bisphosphate aldolase activity
Vpar_1151	COG2244	polysaccharide biosynthetic process
Vpar_1153	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Vpar_1156	COG0546	phosphoglycolate phosphatase activity
Vpar_1168	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Vpar_1169	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Vpar_1170	COG0471	metal ion transport
Vpar_1171	COG2814	Major facilitator Superfamily
Vpar_1172	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vpar_1179	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Vpar_1182	COG1388	LysM domain
Vpar_1182	COG0791	NLP P60 protein
Vpar_1183	COG0463	Glycosyl transferase, family 2
Vpar_1185	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Vpar_1189	COG3118	belongs to the thioredoxin family
Vpar_1190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Vpar_1193	COG0602	queuosine metabolic process
Vpar_1195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Vpar_1196	COG0358	DNA primase activity
Vpar_1197	COG1418	mRNA catabolic process
Vpar_1198	COG2137	regulation of response to DNA damage stimulus
Vpar_1199	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Vpar_1200	COG1546	Belongs to the CinA family
Vpar_1200	COG1058	Belongs to the CinA family
Vpar_1204	COG1426	Protein conserved in bacteria
Vpar_1207	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Vpar_1209	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vpar_1210	COG0735	belongs to the Fur family
Vpar_1211	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vpar_1212	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vpar_1213	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Vpar_1213	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Vpar_1214	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Vpar_1215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Vpar_1217	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Vpar_1219	COG1530	ribonuclease E activity
Vpar_1222	COG0772	Belongs to the SEDS family
Vpar_1223	COG2894	cell division
Vpar_1224	COG0768	penicillin binding
Vpar_1226	COG1792	Involved in formation and maintenance of cell shape
Vpar_1227	COG1077	Cell shape determining protein MreB Mrl
Vpar_1228	COG2003	Belongs to the UPF0758 family
Vpar_1229	COG0424	maF-like protein
Vpar_1233	COG1323	Belongs to the UPF0348 family
Vpar_1235	COG0564	pseudouridine synthase activity
Vpar_1238	COG0490	domain, Protein
Vpar_1238	COG0471	metal ion transport
Vpar_1240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Vpar_1241	COG4770	biotin carboxylase activity
Vpar_1244	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vpar_1245	COG0346	lactoylglutathione lyase activity
Vpar_1247	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vpar_1247	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vpar_1249	COG0427	acetyl-CoA hydrolase
Vpar_1251	COG0285	dihydrofolate synthase activity
Vpar_1252	COG0525	valine-tRNA ligase activity
Vpar_1253	COG0805	protein transport
Vpar_1255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Vpar_1256	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Vpar_1257	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Vpar_1258	COG0740	serine-type endopeptidase activity
Vpar_1259	COG0544	peptidyl-prolyl cis-trans isomerase activity
Vpar_1260	COG0516	GMP reductase activity
Vpar_1260	COG0517	IMP dehydrogenase activity
Vpar_1261	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Vpar_1262	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Vpar_1263	COG1850	ribulose-bisphosphate carboxylase activity
Vpar_1264	COG2233	PERMEase
Vpar_1267	COG0493	'glutamate synthase
Vpar_1267	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vpar_1268	COG0402	S-adenosylhomocysteine deaminase activity
Vpar_1269	COG0549	Belongs to the carbamate kinase family
Vpar_1270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vpar_1271	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vpar_1279	COG1970	mechanosensitive ion channel activity
Vpar_1280	COG3593	DNA synthesis involved in DNA repair
Vpar_1283	COG2837	iron assimilation
Vpar_1285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vpar_1287	COG2233	PERMEase
Vpar_1288	COG3404	Formiminotransferase-cyclodeaminase
Vpar_1290	COG3273	potassium ion transport
Vpar_1290	COG0471	metal ion transport
Vpar_1293	COG2207	Transcriptional regulator
Vpar_1295	COG2207	Transcriptional regulator
Vpar_1300	COG3859	Proton-coupled thiamine transporter YuaJ
Vpar_1301	COG0516	GMP reductase activity
Vpar_1302	COG2223	nitrite transmembrane transporter activity
Vpar_1305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vpar_1306	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vpar_1307	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vpar_1309	COG1473	amidohydrolase
Vpar_1311	COG0288	reversible hydration of carbon dioxide
Vpar_1312	COG0440	acetolactate synthase activity
Vpar_1313	COG0028	Belongs to the TPP enzyme family
Vpar_1315	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Vpar_1318	COG1704	LemA family
Vpar_1326	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Vpar_1327	COG3679	Belongs to the UPF0342 family
Vpar_1328	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Vpar_1329	COG0315	cyclic pyranopterin monophosphate synthase activity
Vpar_1330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Vpar_1334	COG0569	domain protein
Vpar_1335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vpar_1336	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vpar_1340	COG0848	biopolymer transport protein
Vpar_1341	COG0811	peptide transport
Vpar_1342	COG4771	TonB-dependent receptor
Vpar_1343	COG4771	TonB-dependent receptor
Vpar_1343	COG4771	TonB-dependent receptor
Vpar_1344	COG0662	Cupin 2, conserved barrel domain protein
Vpar_1344	COG2207	Transcriptional regulator
Vpar_1349	COG4139	cobalamin transport
Vpar_1350	COG1120	ATPase activity
Vpar_1353	COG0306	phosphate transporter
Vpar_1356	COG0488	(ABC) transporter
Vpar_1358	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Vpar_1359	COG0776	regulation of translation
Vpar_1360	COG3956	TIGRFAM MazG family protein
Vpar_1361	COG2244	polysaccharide biosynthetic process
Vpar_1362	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Vpar_1363	COG0842	Transport permease protein
Vpar_1364	COG0842	Transport permease protein
Vpar_1365	COG1131	(ABC) transporter
Vpar_1369	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Vpar_1371	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Vpar_1372	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Vpar_1374	COG0419	ATPase involved in DNA repair
Vpar_1376	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Vpar_1377	COG0735	belongs to the Fur family
Vpar_1378	COG0513	Belongs to the DEAD box helicase family
Vpar_1381	COG3048	D-serine ammonia-lyase activity
Vpar_1382	COG1012	belongs to the aldehyde dehydrogenase family
Vpar_1383	COG2183	response to ionizing radiation
Vpar_1384	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Vpar_1385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Vpar_1386	COG0514	ATP-dependent DNA helicase (RecQ)
Vpar_1387	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vpar_1389	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vpar_1389	COG4797	methyltransferase
Vpar_1391	COG0583	DNA-binding transcription factor activity
Vpar_1400	COG2301	Belongs to the HpcH HpaI aldolase family
Vpar_1401	COG3052	prosthetic group binding
Vpar_1402	COG0471	metal ion transport
Vpar_1403	COG0583	DNA-binding transcription factor activity
Vpar_1404	COG0670	Belongs to the BI1 family
Vpar_1413	COG3210	domain, Protein
Vpar_1422	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vpar_1423	COG0113	porphobilinogen synthase activity
Vpar_1424	COG1587	Uroporphyrinogen-III synthase
Vpar_1424	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vpar_1426	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vpar_1427	COG1648	precorrin-2 dehydrogenase activity
Vpar_1427	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vpar_1428	COG2302	S4 RNA-binding domain
Vpar_1429	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Vpar_1430	COG1799	cell septum assembly
Vpar_1433	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vpar_1436	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vpar_1437	COG1119	ATPase activity
Vpar_1439	COG0028	Belongs to the TPP enzyme family
Vpar_1440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vpar_1441	COG0129	dihydroxy-acid dehydratase activity
Vpar_1443	COG0471	metal ion transport
Vpar_1444	COG0662	Cupin 2, conserved barrel domain protein
Vpar_1446	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vpar_1447	COG0363	glucosamine-6-phosphate deaminase activity
Vpar_1448	COG1024	Enoyl-CoA hydratase
Vpar_1450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Vpar_1453	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Vpar_1454	COG0583	DNA-binding transcription factor activity
Vpar_1455	COG1742	UPF0060 membrane protein
Vpar_1456	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vpar_1457	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vpar_1459	COG0534	Mate efflux family protein
Vpar_1460	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vpar_1461	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vpar_1461	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vpar_1463	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Vpar_1465	COG1122	ATPase activity
Vpar_1466	COG0203	ribosomal protein L17
Vpar_1467	COG0202	RNA polymerase activity
Vpar_1470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Vpar_1474	COG0201	protein transport
Vpar_1475	COG0200	Binds to the 23S rRNA
Vpar_1476	COG1841	ribosomal large subunit assembly
Vpar_1477	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Vpar_1478	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Vpar_1480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vpar_1481	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Vpar_1482	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Vpar_1484	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Vpar_1487	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Vpar_1488	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Vpar_1489	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Vpar_1490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vpar_1491	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vpar_1492	COG0089	rRNA binding
Vpar_1493	COG0088	Forms part of the polypeptide exit tunnel
Vpar_1494	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vpar_1495	COG0051	transcription antitermination factor activity, RNA binding
Vpar_1496	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vpar_1498	COG0049	tRNA binding
Vpar_1499	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Vpar_1501	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vpar_1502	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vpar_1503	COG0085	RNA polymerase activity
Vpar_1504	COG1027	Aspartate ammonia-lyase
Vpar_1505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Vpar_1506	COG0222	ribosome binding
Vpar_1508	COG0081	regulation of translation
Vpar_1509	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Vpar_1510	COG0250	Participates in transcription elongation, termination and antitermination
Vpar_1511	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vpar_1514	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vpar_1517	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Vpar_1519	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Vpar_1520	COG0768	penicillin binding
Vpar_1521	COG0617	tRNA 3'-terminal CCA addition
Vpar_1522	COG1760	l-serine dehydratase
Vpar_1523	COG1760	l-serine dehydratase
Vpar_1524	COG1151	hydroxylamine reductase activity
Vpar_1529	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Vpar_1531	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Vpar_1534	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Vpar_1535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Vpar_1536	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Vpar_1537	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Vpar_1538	COG0356	it plays a direct role in the translocation of protons across the membrane
Vpar_1541	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Vpar_1542	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Vpar_1543	COG2848	UPF0210 protein
Vpar_1544	COG3830	Belongs to the UPF0237 family
Vpar_1545	COG0033	Phosphoglucomutase
Vpar_1546	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Vpar_1547	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Vpar_1548	COG1802	Transcriptional regulator
Vpar_1549	COG1115	amino acid carrier protein
Vpar_1550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Vpar_1552	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vpar_1553	COG0708	Exodeoxyribonuclease III
Vpar_1556	COG0494	nUDIX hydrolase
Vpar_1559	COG0747	negative chemotaxis
Vpar_1561	COG0444	Belongs to the ABC transporter superfamily
Vpar_1562	COG0747	negative chemotaxis
Vpar_1566	COG0531	amino acid
Vpar_1567	COG0165	Argininosuccinate lyase
Vpar_1574	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vpar_1575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Vpar_1576	COG1757	Na H antiporter
Vpar_1577	COG1105	Belongs to the carbohydrate kinase PfkB family
Vpar_1578	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vpar_1578	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vpar_1578	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vpar_1582	COG0450	alkyl hydroperoxide reductase
Vpar_1584	COG0504	CTP synthase activity
Vpar_1585	COG0018	arginyl-trna synthetase
Vpar_1590	COG0561	phosphatase activity
Vpar_1592	COG0371	Dehydrogenase
Vpar_1593	COG1114	Component of the transport system for branched-chain amino acids
Vpar_1594	COG0243	molybdopterin cofactor binding
Vpar_1595	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Vpar_1596	COG1620	l-lactate permease
Vpar_1598	COG2814	Major facilitator Superfamily
Vpar_1602	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vpar_1604	COG1454	alcohol dehydrogenase
Vpar_1606	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vpar_1607	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vpar_1610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Vpar_1612	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vpar_1613	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vpar_1614	COG1605	Chorismate mutase
Vpar_1614	COG0077	Prephenate dehydratase
Vpar_1618	COG0710	3-dehydroquinate dehydratase activity
Vpar_1619	COG2814	Major facilitator Superfamily
Vpar_1620	COG1959	2 iron, 2 sulfur cluster binding
Vpar_1621	COG2252	PERMEase
Vpar_1627	COG1113	amino acid transport
Vpar_1631	COG0564	pseudouridine synthase activity
Vpar_1634	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Vpar_1635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Vpar_1636	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Vpar_1637	COG0069	glutamate synthase activity
Vpar_1637	COG0070	glutamate synthase
Vpar_1637	COG0067	glutamate synthase
Vpar_1638	COG0564	pseudouridine synthase activity
Vpar_1642	COG0656	L-ascorbic acid biosynthetic process
Vpar_1643	COG1687	branched-chain amino acid
Vpar_1644	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Vpar_1645	COG1979	alcohol dehydrogenase
Vpar_1648	COG2146	nitrite reductase [NAD(P)H] activity
Vpar_1648	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vpar_1650	COG1556	Lactate utilization protein
Vpar_1651	COG1139	Iron-sulfur cluster binding protein
Vpar_1652	COG0247	lactate metabolic process
Vpar_1656	COG1297	OPT oligopeptide transporter protein
Vpar_1658	COG1408	metallophosphoesterase
Vpar_1664	COG1196	nuclear chromosome segregation
Vpar_1666	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Vpar_1669	COG1597	lipid kinase activity
Vpar_1670	COG1074	ATP-dependent DNA helicase activity
Vpar_1671	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Vpar_1676	COG2217	Heavy metal translocating P-type atpase
Vpar_1677	COG1174	glycine betaine transport
Vpar_1679	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vpar_1681	COG0305	Participates in initiation and elongation during chromosome replication
Vpar_1683	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Vpar_1685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Vpar_1688	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vpar_1688	COG1116	anion transmembrane transporter activity
Vpar_1689	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vpar_1690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vpar_1691	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Vpar_1692	COG0586	Pfam SNARE associated Golgi protein
Vpar_1693	COG1120	ATPase activity
Vpar_1694	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vpar_1696	COG4771	TonB-dependent receptor
Vpar_1698	COG0848	biopolymer transport protein
Vpar_1699	COG0811	peptide transport
Vpar_1702	COG0515	serine threonine protein kinase
Vpar_1703	COG2048	Heterodisulfide reductase, subunit B
Vpar_1704	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Vpar_1705	COG1053	succinate dehydrogenase
Vpar_1707	COG0642	Histidine kinase
Vpar_1708	COG2733	membrane
Vpar_1709	COG2733	membrane
Vpar_1711	COG1733	regulation of RNA biosynthetic process
Vpar_1712	COG3384	dioxygenase
Vpar_1713	COG0386	Belongs to the glutathione peroxidase family
Vpar_1716	COG0280	phosphate acetyltransferase
Vpar_1719	COG0493	'glutamate synthase
Vpar_1720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Vpar_1722	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Vpar_1724	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Vpar_1726	COG2824	Alkylphosphonate utilization operon protein PhnA
Vpar_1729	COG0789	Transcriptional regulator
Vpar_1733	COG2249	NAD(P)H dehydrogenase (quinone) activity
Vpar_1740	COG4268	DNA restriction-modification system
Vpar_1741	COG1401	restriction endodeoxyribonuclease activity
Vpar_1745	COG0753	catalase activity
Vpar_1747	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vpar_1749	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vpar_1750	COG1396	sequence-specific DNA binding
Vpar_1750	COG1917	Cupin 2, conserved barrel domain protein
Vpar_1753	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Vpar_1756	COG0848	biopolymer transport protein
Vpar_1757	COG0811	peptide transport
Vpar_1761	COG1703	isobutyryl-CoA mutase activity
Vpar_1762	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vpar_1762	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vpar_1763	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vpar_1763	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vpar_1764	COG2962	Rard protein
Vpar_1768	COG0277	FAD linked oxidase domain protein
Vpar_1772	COG1454	alcohol dehydrogenase
Vpar_1778	COG1846	Transcriptional regulator
Vpar_1781	COG2271	Major facilitator Superfamily
Vpar_1783	COG1393	Belongs to the ArsC family
Vpar_1785	COG3549	Plasmid maintenance system killer
Vpar_1788	COG0519	Catalyzes the synthesis of GMP from XMP
Vpar_1802	COG1332	CRISPR-associated RAMP protein, Csm5 family
Vpar_1803	COG1567	CRISPR-associated RAMP protein, Csm4 family
Vpar_1804	COG1337	RAMP superfamily
Vpar_1806	COG1353	crispr-associated protein
Vpar_1829	COG1472	Belongs to the glycosyl hydrolase 3 family
Vpar_1833	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Vpar_1835	COG1489	DNA binding
Vpar_1836	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vpar_1843	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Vpar_1844	COG0741	lytic transglycosylase activity
Vpar_1844	COG0739	heme binding
Vpar_1844	COG1196	nuclear chromosome segregation
Vpar_1846	COG1160	GTP binding
Vpar_1847	COG1475	DNA binding
Vpar_1848	COG1192	Involved in chromosome partitioning
Vpar_1850	COG0646	methionine synthase
Vpar_1850	COG1410	methionine synthase
Vpar_1851	COG0646	methionine synthase
Vpar_1851	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Vpar_1852	COG0357	Ribosomal RNA small subunit methyltransferase G
Vpar_1853	COG0445	tRNA wobble uridine modification
Vpar_1855	COG1847	R3H domain protein
Vpar_1856	COG0706	membrane insertase activity
Vpar_1857	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Vpar_1858	COG0594	ribonuclease P activity
Vpar_1859	COG0230	Belongs to the bacterial ribosomal protein bL34 family