locus-tag class description VEIT17_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) VEIT17_00030 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) VEIT17_00050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) VEIT17_00080 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEIT17_00090 ENOG4108IQI permease VEIT17_00110 ENOG4107Z6X Transcriptional regulator VEIT17_00150 ENOG4105DJY efflux transporter, rnd family, mfp subunit VEIT17_00220 ENOG4108PQP glycosyl transferase group 1 VEIT17_00250 ENOG4105D3Q Sugar transferase VEIT17_00260 ENOG4108TGC Acyltransferase VEIT17_00270 ENOG4105D5D udp-galactopyranose mutase VEIT17_00300 ENOG4108KMV Glycosyl transferase (Group 1 VEIT17_00320 ENOG4105ER6 polysaccharide biosynthesis protein VEIT17_00450 ENOG4106R49 Methyltransferase VEIT17_00500 ENOG4105EUB pirin domain protein VEIT17_00530 ENOG4105D0M Protease HtpX homolog VEIT17_00570 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) VEIT17_00590 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) VEIT17_00600 ENOG4105EHG Permease protein VEIT17_00610 ENOG4105E0A ABC, transporter VEIT17_00640 ENOG4105CTK cobaltochelatase, cobn subunit VEIT17_00660 ENOG4105D05 Receptor VEIT17_00670 ENOG4105CHM Aminotransferase VEIT17_00680 ENOG4105WAB arsR family transcriptional regulator VEIT17_00690 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VEIT17_00700 ENOG41090P5 ferredoxin-like protein VEIT17_00710 ENOG4105BZJ Electron transfer flavoprotein VEIT17_00720 ENOG4105C10 Electron transfer flavoprotein VEIT17_00730 ENOG4105EMU Dehydrogenase VEIT17_00770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEIT17_00780 ENOG4107RRN ABC transporter substrate-binding protein VEIT17_00790 ENOG4105C3U ABC transporter VEIT17_00800 ENOG4108JQ7 (ABC) transporter VEIT17_00910 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) VEIT17_00920 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VEIT17_00930 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VEIT17_00940 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VEIT17_00960 ENOG4105RNB VEIT17_00990 ENOG4105DQ6 Transposase VEIT17_01000 ENOG4105QZY s-layer domain protein VEIT17_01050 ENOG4105ZU5 s-layer protein VEIT17_01070 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VEIT17_01080 ENOG4105CNN ABC, transporter VEIT17_01090 ENOG4105C2J ABC transporter VEIT17_01100 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) VEIT17_01110 ENOG4108RVA ribokinase VEIT17_01160 ENOG4105DZR Type I site-specific deoxyribonuclease VEIT17_01190 ENOG4108JJB ABC transporter VEIT17_01200 ENOG4108JJB ABC transporter VEIT17_01230 ENOG4108W76 histidinol phosphate phosphatase hisj family VEIT17_01240 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) VEIT17_01350 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) VEIT17_01380 ENOG4105C6T cysteine synthase VEIT17_01390 ENOG4105D7W serine acetyltransferase VEIT17_01410 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) VEIT17_01430 ENOG4105D1Q UPF0246 protein VEIT17_01440 ENOG4107QW8 radical SAM domain protein VEIT17_01460 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VEIT17_01470 ENOG4108R66 Conserved Protein VEIT17_01480 ENOG4108UZ3 Transporter VEIT17_01570 ENOG4105DDQ anthranilate synthase VEIT17_01600 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) VEIT17_01610 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) VEIT17_01670 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) VEIT17_01720 ENOG4107R0W ABC transporter VEIT17_01750 ENOG410667J hydrolase VEIT17_01770 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VEIT17_01890 ENOG4105SUU thioesterase domain VEIT17_01900 ENOG4105CC5 ABC transporter VEIT17_01910 ENOG4107RPQ ABC transporter VEIT17_01920 ENOG4105DIK (ABC) transporter VEIT17_01930 ENOG4107SIG periplasmic solute binding protein VEIT17_01950 ENOG4105WQ5 TonB family VEIT17_01980 ENOG4108WAV Transcriptional regulator VEIT17_01990 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit VEIT17_02000 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein VEIT17_02030 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) VEIT17_02040 ENOG4107VRP DNA repair exonuclease VEIT17_02050 ENOG4106D4I domain protein VEIT17_02060 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) VEIT17_02070 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) VEIT17_02080 ENOG4105C1Q protoporphyrinogen oxidase VEIT17_02090 ENOG4107JTW chlorite dismutase VEIT17_02100 ENOG4105DQQ Major facilitator superfamily MFS_1 VEIT17_02110 ENOG4107V6Q Cyclic nucleotide-binding domain VEIT17_02130 ENOG4108IUE nitrate reductase beta subunit VEIT17_02140 ENOG4105R3A Nitrate reductase VEIT17_02170 ENOG4105ZU5 s-layer protein VEIT17_02190 ENOG4105C6X Major Facilitator VEIT17_02200 ENOG4105DZ2 Transcriptional regulator VEIT17_02220 ENOG4105HMI Membrane VEIT17_02230 ENOG4108V2W Carbonate dehydratase VEIT17_02240 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VEIT17_02250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VEIT17_02260 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VEIT17_02280 ENOG4105FAV ABC, transporter VEIT17_02290 ENOG4105FDK ABC transporter VEIT17_02300 ENOG4105DSE periplasmic solute binding protein VEIT17_02310 ENOG4105MZU cell filamentation protein VEIT17_02420 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VEIT17_02430 ENOG4105C5I Dehydrogenase VEIT17_02440 ENOG4105F1A Pyruvate formate-lyase VEIT17_02450 ENOG4105C6N Formate acetyltransferase VEIT17_02490 ENOG4108UMI ABC transporter, permease VEIT17_02500 ENOG4105D01 (LipO)protein VEIT17_02510 ENOG4105BZ1 (ABC) transporter VEIT17_02530 ENOG4107QPK )-transporter VEIT17_02560 ENOG4105C28 cystathionine VEIT17_02570 ENOG4105C87 Aminotransferase class I and II VEIT17_02640 ENOG4108PJD permease VEIT17_02650 ENOG4105CKI cobalamin synthesis protein VEIT17_02660 ENOG4105CIN aminoacyl-histidine dipeptidase VEIT17_02670 ENOG4105DAP Nicotinate phosphoribosyltransferase VEIT17_02690 ENOG4107RB3 L-asparaginase VEIT17_02710 ENOG4105D64 Mechanosensitive ion channel VEIT17_02720 ENOG4105DZ1 carboxypeptidase VEIT17_02740 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VEIT17_02760 ENOG4108XHQ (2Fe-2S)-binding domain protein VEIT17_02770 ENOG4105C7W Xanthine dehydrogenase VEIT17_02810 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family VEIT17_02830 ENOG4105C8B TIGR00159 family VEIT17_02840 ENOG4107U5W ybbr family VEIT17_02850 ENOG4105DZ0 fad dependent oxidoreductase VEIT17_02860 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VEIT17_02900 ENOG4105DQ6 Transposase VEIT17_02910 ENOG4108QDQ Ubiquinol-cytochrome C chaperone VEIT17_02920 ENOG4108PZQ Inner membrane protein YeeR VEIT17_02940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) VEIT17_02950 ENOG4105C31 Tryptophanyl-tRNA synthetase VEIT17_02970 ENOG4107R0W ABC transporter VEIT17_02980 ENOG4105E5Q amino acid AbC transporter VEIT17_03020 ENOG4107YCR Transcriptional regulator, ARSR family VEIT17_03050 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein VEIT17_03060 ENOG4105E0C molybdate abc transporter VEIT17_03070 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) VEIT17_03120 ENOG4108RAC Rubrerythrin VEIT17_03140 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) VEIT17_03170 ENOG4108RCM Nitroreductase VEIT17_03180 ENOG4107BMA Transglycosylase associated protein VEIT17_03200 ENOG4105C3G gtp-binding protein VEIT17_03260 ENOG4105C2C drug resistance transporter, Bcr CflA VEIT17_03270 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) VEIT17_03280 ENOG4108UUM single-stranded DNA-binding protein VEIT17_03290 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) VEIT17_03320 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB VEIT17_03360 ENOG4108RS6 transposase VEIT17_03370 ENOG4105VUF Transcriptional regulator VEIT17_03380 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VEIT17_03390 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VEIT17_03410 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) VEIT17_03420 ENOG4105CNI cell division protein FtsW VEIT17_03510 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VEIT17_03540 ENOG4108J5H Homocysteine s-methyltransferase VEIT17_03560 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii VEIT17_03570 ENOG4108M0I Transcriptional regulator VEIT17_03580 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) VEIT17_03610 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) VEIT17_03620 ENOG4105C8V SAICAR synthetase VEIT17_03630 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase VEIT17_03640 ENOG4105CXB phosphoribosylaminoimidazole synthetase VEIT17_03650 ENOG4108V3E phosphoribosylglycinamide formyltransferase VEIT17_03670 ENOG4105C12 Phosphoribosylglycinamide synthetase VEIT17_03680 ENOG4105E4F Isochorismate synthase VEIT17_03690 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) VEIT17_03700 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) VEIT17_03710 ENOG4108IPT Naphthoate synthase VEIT17_03720 ENOG4105CEY Amp-dependent synthetase and ligase VEIT17_03730 ENOG4105DTQ mandelate racemase muconate lactonizing VEIT17_03790 ENOG4105CXY transporter VEIT17_03840 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase VEIT17_03850 ENOG4107BJW polysaccharide deacetylase VEIT17_03860 ENOG4108HQ0 Exopolysaccharide biosynthesis protein VEIT17_03880 ENOG4105XA0 heptosyltransferase ii VEIT17_03900 ENOG4107QSA Oxaloacetate decarboxylase VEIT17_03930 ENOG4105C0H protease VEIT17_03980 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) VEIT17_03990 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) VEIT17_04000 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) VEIT17_04040 ENOG4105D01 (LipO)protein VEIT17_04050 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase VEIT17_04080 ENOG4105KME endoribonuclease L-psp VEIT17_04090 ENOG4105CEM UPF0597 protein VEIT17_04100 ENOG4105EU0 Major facilitator Superfamily VEIT17_04110 ENOG4108Z6B deaminase VEIT17_04120 ENOG4105EN6 Membrane VEIT17_04150 ENOG4105F0I Aminotransferase VEIT17_04160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VEIT17_04170 ENOG4108UMI ABC transporter, permease VEIT17_04180 ENOG4105KGF protein, YerC YecD VEIT17_04190 ENOG4105EJ9 Membrane VEIT17_04200 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr VEIT17_04240 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) VEIT17_04270 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) VEIT17_04280 ENOG4105DGU Histone deacetylase VEIT17_04290 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) VEIT17_04330 ENOG4105C6K Malic enzyme VEIT17_04380 ENOG4105E7W lamb ycsf family protein VEIT17_04390 ENOG4105C5A transporter VEIT17_04400 ENOG4105P4J Allophanate hydrolase, subunit 1 VEIT17_04440 ENOG4105UQX Mate efflux family protein VEIT17_04450 ENOG4108ZG0 Ompa motb domain protein VEIT17_04460 ENOG4105C02 permease VEIT17_04500 ENOG4108FUT Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) VEIT17_04510 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VEIT17_04550 ENOG4108JA2 transcriptioN-repair coupling factor VEIT17_04560 ENOG4105CKP Polysaccharide Biosynthesis Protein VEIT17_04570 ENOG4105DXN mazG family VEIT17_04580 ENOG4105K70 DNA-binding protein VEIT17_04610 ENOG4105C5H ABC transporter VEIT17_04620 ENOG4107QHI -hydrogenase VEIT17_04640 ENOG4105CJ3 phosphate transporter VEIT17_04670 ENOG4105E0A ABC, transporter VEIT17_04680 ENOG4105S6R Iron-hydroxamate transporter permease subunit VEIT17_04730 ENOG4105FTV AraC Family Transcriptional Regulator VEIT17_04740 ENOG4105D05 Receptor VEIT17_04760 ENOG4109015 Biopolymer transport protein exbD tolR VEIT17_04790 ENOG4105D4P Coproporphyrinogen iii oxidase VEIT17_04800 ENOG4108MGF sugar kinase VEIT17_04810 ENOG4105CZN Potassium uptake protein VEIT17_04820 ENOG4107ZYR domain protein VEIT17_04860 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein VEIT17_04880 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) VEIT17_04890 ENOG4105WZB UPF0342 protein VEIT17_04910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VEIT17_04920 ENOG4105CI3 gtp-binding protein typa VEIT17_05010 ENOG4105C7K acetolactate synthase VEIT17_05020 ENOG4108ZP8 Acetolactate synthase small subunit VEIT17_05030 ENOG4108V2W Carbonate dehydratase VEIT17_05060 ENOG4105CH2 amidohydrolase VEIT17_05080 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase VEIT17_05090 ENOG4105CAS nag kinase VEIT17_05100 ENOG4105C8Y Acetylornithine aminotransferase VEIT17_05130 ENOG4105CEE C4-dicarboxylate transporter VEIT17_05150 ENOG4106UW1 Major Facilitator superfamily VEIT17_05160 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) VEIT17_05170 ENOG4105N67 Proton-coupled thiamine transporter YuaJ VEIT17_05210 ENOG4108WZA zeta toxin VEIT17_05220 ENOG41075H3 AraC family transcriptional regulator VEIT17_05240 ENOG4105W4W Transcriptional regulator VEIT17_05250 ENOG4106DSS Tartrate dehydratase subunit alpha VEIT17_05260 ENOG4107GFK fumarate VEIT17_05270 ENOG4105C8P )-transporter VEIT17_05280 ENOG4105CKU formyltetrahydrofolate synthetase VEIT17_05300 ENOG4105C2W permease VEIT17_05320 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VEIT17_05350 ENOG4105EZR dyp-type peroxidase family protein VEIT17_05360 ENOG4107QID Threonine synthase VEIT17_05380 ENOG4105CPB ATP-dependent endonuclease of the OLD family VEIT17_05390 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) VEIT17_05400 ENOG4105C5I Dehydrogenase VEIT17_05440 ENOG4108Z29 Flavodoxin VEIT17_05460 ENOG4107RCH Diaminopropionate ammonia-lyase VEIT17_05470 ENOG4107S4Y M20 DapE family protein YgeY VEIT17_05480 ENOG4105IW6 Carbamoyltransferase VEIT17_05490 ENOG4105C5B carbamate kinase VEIT17_05500 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) VEIT17_05510 ENOG4105BZ8 glutamate synthase VEIT17_05540 ENOG4105C2W permease VEIT17_05550 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit VEIT17_05560 ENOG4105Q2H domain protein VEIT17_05570 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) VEIT17_05580 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VEIT17_05590 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation VEIT17_05600 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VEIT17_05610 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) VEIT17_05620 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VEIT17_05630 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) VEIT17_05650 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) VEIT17_05660 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) VEIT17_05670 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase VEIT17_05700 ENOG4105CYC Transferase VEIT17_05740 ENOG4108ZVT methylmalonyl-coA epimerase VEIT17_05780 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein VEIT17_05790 ENOG4105D9Q decarboxylase (Beta subunit) VEIT17_05810 ENOG4107QWE )-transporter VEIT17_05830 ENOG4107QWE )-transporter VEIT17_05860 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) VEIT17_05870 ENOG4105C34 Pseudouridine synthase VEIT17_05930 ENOG4108Z03 MAF-like protein VEIT17_05940 ENOG4105W5Q DNA repair protein (RadC VEIT17_05950 ENOG4105DFF Rod shape-determining protein mreb VEIT17_05980 ENOG4105CJN penicillin-binding protein VEIT17_06000 ENOG4105CNI cell division protein FtsW VEIT17_06030 ENOG4105C03 ribonuclease VEIT17_06050 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) VEIT17_06070 ENOG4105K46 50S ribosomal protein l27 VEIT17_06080 ENOG41083J0 (ABC) transporter VEIT17_06090 ENOG4105C4B ABC transporter, permease VEIT17_06100 ENOG4107QW8 radical SAM domain protein VEIT17_06110 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) VEIT17_06120 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VEIT17_06130 ENOG4107VMB Beta-lactamase domain protein VEIT17_06140 ENOG4105I3K Ferric uptake regulator, Fur family VEIT17_06150 ENOG4105D4P Coproporphyrinogen iii oxidase VEIT17_06170 ENOG4105C9M aspartyl-trna synthetase VEIT17_06190 ENOG4105CNU cell division protein FtsK VEIT17_06230 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) VEIT17_06240 ENOG4105CEV competence damage-inducible protein VEIT17_06250 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) VEIT17_06260 ENOG410902V Modulates RecA activity (By similarity) VEIT17_06270 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) VEIT17_06280 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) VEIT17_06290 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEIT17_06310 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) VEIT17_06340 ENOG4105EGD dinuclear metal center protein, YbgI family VEIT17_06350 ENOG4105K63 Thioredoxin VEIT17_06360 ENOG4105E3S small subunit VEIT17_06390 ENOG4108USZ hydrogenase VEIT17_06410 ENOG4105CKK Glycosyl transferase, family 2 VEIT17_06450 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) VEIT17_06460 ENOG41068XD UPF0473 protein VEIT17_06500 ENOG4105CFP Peptidase U32 VEIT17_06530 ENOG4105C22 threonyL-tRNA synthetase VEIT17_06540 ENOG4107RGD Major Facilitator superfamily VEIT17_06550 ENOG4107QPK )-transporter VEIT17_06560 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) VEIT17_06570 ENOG4105VJV 50s ribosomal protein L35 VEIT17_06650 ENOG4105DB4 VEIT17_06760 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VEIT17_06790 ENOG4108Z86 Glutamine amidotransferase VEIT17_06820 ENOG4105CKP Polysaccharide Biosynthesis Protein VEIT17_06830 ENOG4105D2N Aldolase VEIT17_06840 ENOG4105EMS pseudouridine synthase VEIT17_06870 ENOG4108VPT UPF0234 protein VEIT17_06880 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) VEIT17_06900 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase VEIT17_06910 ENOG4105CIA precorrin-4 C(11)-methyltransferase VEIT17_06920 ENOG4108P62 biosynthesis protein (CbiG) VEIT17_06930 ENOG4105E4R Precorrin-3B C17-methyltransferase VEIT17_06940 ENOG4105QUC reductase VEIT17_06950 ENOG41081F0 Precorrin-8x methylmutase VEIT17_06960 ENOG4108U1V ABC transporter, permease VEIT17_06970 ENOG4105E0A ABC, transporter VEIT17_06990 ENOG4107PPM cobalt chelatase VEIT17_07010 ENOG4107PPM cobalt chelatase VEIT17_07020 ENOG4105DVK Precorrin-2 c20-methyltransferase VEIT17_07030 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VEIT17_07050 ENOG4108YZ8 Superoxide reductase VEIT17_07090 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) VEIT17_07110 ENOG4105K63 Thioredoxin VEIT17_07130 ENOG4108V6E Cell division protein mraZ VEIT17_07140 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) VEIT17_07160 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) VEIT17_07170 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) VEIT17_07180 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) VEIT17_07200 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) VEIT17_07210 ENOG4105DFU Cell wall formation (By similarity) VEIT17_07220 ENOG4105CPF Cell wall formation (By similarity) VEIT17_07250 ENOG4105K67 small basic protein VEIT17_07260 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) VEIT17_07300 ENOG4105CSM endonuclease III VEIT17_07330 ENOG41082DI 50s ribosomal protein l31 VEIT17_07340 ENOG4105CBJ Metal-dependent enzyme VEIT17_07360 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) VEIT17_07370 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VEIT17_07380 ENOG4107WAU Protein tyrosine phosphatase VEIT17_07390 ENOG4108YZG isomerase VEIT17_07400 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VEIT17_07440 ENOG4105BZA Phosphoglycerate kinase VEIT17_07450 ENOG4105CP7 Triose-phosphate isomerase VEIT17_07470 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) VEIT17_07480 ENOG4107QHF type ii secretion system protein e VEIT17_07490 ENOG4105CZX twitching motility protein VEIT17_07500 ENOG4105D7Q type ii secretion system VEIT17_07510 ENOG4106855 Competence protein VEIT17_07600 ENOG4107ZC0 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) VEIT17_07610 ENOG4105CTQ phosphohexokinase VEIT17_07620 ENOG4105DJY efflux transporter, rnd family, mfp subunit VEIT17_07630 ENOG4105C19 ABC transporter VEIT17_07640 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VEIT17_07660 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) VEIT17_07670 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) VEIT17_07680 ENOG4105CFP Peptidase U32 VEIT17_07690 ENOG4105C98 muts2 protein VEIT17_07700 ENOG4108JQC penicillin-binding protein 1A VEIT17_07710 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VEIT17_07750 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) VEIT17_07760 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein VEIT17_07790 ENOG41069HH 4-oxalocrotonate tautomerase VEIT17_07800 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VEIT17_07820 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme VEIT17_07880 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) VEIT17_07890 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 VEIT17_07900 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VEIT17_07920 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) VEIT17_07930 ENOG4105K8N protein family UPF0079, ATPase VEIT17_07940 ENOG41072GX Peptidase M22 Glycoprotease VEIT17_07990 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VEIT17_08000 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VEIT17_08030 ENOG4105C3K feS assembly ATPase SufC VEIT17_08060 ENOG4105C9B Cysteine desulfurase VEIT17_08070 ENOG4107YH3 SUF system FeS assembly protein, NifU family VEIT17_08110 ENOG4108Z0C Uvrb UvrC protein VEIT17_08120 ENOG41066A3 ATP guanido phosphotransferase VEIT17_08140 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) VEIT17_08150 ENOG4105CTP PilT protein domain protein VEIT17_08160 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) VEIT17_08170 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) VEIT17_08180 ENOG4105C09 Bile acid VEIT17_08190 ENOG4105C8N cysteinyl-tRNA synthetase VEIT17_08200 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) VEIT17_08210 ENOG4105C2N RNA methyltransferase TrmH family group 3 VEIT17_08230 ENOG4105QIV RNA polymerase VEIT17_08240 ENOG4105XZU Preprotein translocase, subunit SecG VEIT17_08250 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VEIT17_08260 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) VEIT17_08280 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) VEIT17_08320 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase VEIT17_08330 ENOG4105C4R Atp-dependent dna helicase VEIT17_08340 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) VEIT17_08380 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) VEIT17_08390 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) VEIT17_08420 ENOG4105N5T Radical SAM Protein VEIT17_08430 ENOG4105C9A Phoh family VEIT17_08450 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) VEIT17_08460 ENOG4105C37 (CBS) domain VEIT17_08570 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit VEIT17_08580 ENOG4105C38 Glycyl-tRNA synthetase beta subunit VEIT17_08600 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) VEIT17_08630 ENOG4105VFF UPF0102 protein VEIT17_08640 ENOG4105C0P Mg chelatase subunit ChlI VEIT17_08650 ENOG4105C79 DNA protecting protein DprA VEIT17_08660 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VEIT17_08670 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) VEIT17_08680 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) VEIT17_08690 ENOG4105VRS hydrolase family 18 VEIT17_08710 ENOG4107YWA deoxycytidylate deaminase VEIT17_08730 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein VEIT17_08760 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) VEIT17_08790 ENOG4105C7K acetolactate synthase VEIT17_08800 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VEIT17_08810 ENOG4108R6K riboflavin synthase, subunit alpha VEIT17_08820 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) VEIT17_08840 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) VEIT17_08850 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) VEIT17_08860 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) VEIT17_08870 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) VEIT17_08880 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) VEIT17_08900 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VEIT17_08960 ENOG41073R8 VanW family VEIT17_08990 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) VEIT17_09000 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VEIT17_09010 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VEIT17_09020 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) VEIT17_09030 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) VEIT17_09050 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) VEIT17_09060 ENOG4105DX0 Hemolysin A VEIT17_09090 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VEIT17_09110 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VEIT17_09120 ENOG4107YIM Involved in the transcription termination process (By similarity) VEIT17_09150 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VEIT17_09160 ENOG4105DC7 peptidase M24 VEIT17_09180 ENOG4105CVJ phosphoglycerate mutase VEIT17_09190 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VEIT17_09200 ENOG4105JZC GHMP kinase VEIT17_09220 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) VEIT17_09230 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VEIT17_09270 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) VEIT17_09280 ENOG4105D0M Protease HtpX homolog VEIT17_09290 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) VEIT17_09300 ENOG4105D6E homoserine dehydrogenase VEIT17_09310 ENOG41090I5 UPF0735 ACT domain-containing protein VEIT17_09330 ENOG410901P UPF0249 protein VEIT17_09340 ENOG4108RWN rrna methyltransferase VEIT17_09350 ENOG4105BZ1 (ABC) transporter VEIT17_09360 ENOG4105BZ1 (ABC) transporter VEIT17_09370 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) VEIT17_09390 ENOG4105KTH gatB Yqey VEIT17_09400 ENOG4105VCC 30S ribosomal protein S21 VEIT17_09410 ENOG4107YU2 histidine triad (hIT) protein VEIT17_09420 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VEIT17_09430 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) VEIT17_09440 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) VEIT17_09450 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VEIT17_09460 ENOG4105CFG Acts as a chaperone (By similarity) VEIT17_09500 ENOG4105CSA Coproporphyrinogen iii oxidase VEIT17_09510 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) VEIT17_09520 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) VEIT17_09530 ENOG4105CXI aluminum resistance protein VEIT17_09540 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) VEIT17_09550 ENOG4107YX5 Pfam:DUF548 VEIT17_09560 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) VEIT17_09610 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) VEIT17_09620 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) VEIT17_09630 ENOG4105DZP Membrane-associated zinc metalloprotease VEIT17_09640 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) VEIT17_09650 ENOG4105KNE Phosphatidate cytidylyltransferase VEIT17_09680 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) VEIT17_09690 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) VEIT17_09700 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) VEIT17_09710 ENOG4105CE9 30S ribosomal protein S2 VEIT17_09720 ENOG4105DJV ribulose-phosphate 3-epimerase VEIT17_09730 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VEIT17_09740 ENOG4105D9P serine threonine protein kinase VEIT17_09750 ENOG4108ZF3 Phosphatase VEIT17_09760 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs VEIT17_09800 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) VEIT17_09810 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VEIT17_09820 ENOG4105C25 Primosomal protein n' VEIT17_09830 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP VEIT17_09840 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase VEIT17_09850 ENOG41084KE Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) VEIT17_09860 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) VEIT17_09880 ENOG4105KC4 UPF0296 protein VEIT17_09890 ENOG4105DSJ YicC domain protein VEIT17_09930 ENOG4106H78 methyltransferase VEIT17_09940 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase VEIT17_09950 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) VEIT17_09960 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) VEIT17_09970 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) VEIT17_09990 ENOG4105CAT Cytidine monophosphate kinase VEIT17_10000 ENOG4105CBX hi0933 family VEIT17_10010 ENOG4105FE9 pseudouridine synthase VEIT17_10020 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) VEIT17_10030 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) VEIT17_10050 ENOG4105EWC Purine nucleoside phosphorylase VEIT17_10060 ENOG4107VMB Beta-lactamase domain protein VEIT17_10070 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VEIT17_10080 ENOG4105C1A potassium transporter peripheral membrane VEIT17_10090 ENOG4105QNR S1 RNA binding domain protein VEIT17_10100 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) VEIT17_10110 ENOG4108KGH TRANSCRIPTIONal VEIT17_10120 ENOG4108WF2 Metal Dependent Phosphohydrolase VEIT17_10130 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) VEIT17_10140 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) VEIT17_10150 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) VEIT17_10170 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control VEIT17_10180 ENOG4105CN1 protease VEIT17_10190 ENOG4105DR5 peptidase VEIT17_10200 ENOG4105CRP Part of the ABC transporter FtsEX involved in VEIT17_10210 ENOG4105CAK Cell division ATP-binding protein ftsE VEIT17_10220 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VEIT17_10230 ENOG4108HHA Transketolase VEIT17_10270 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) VEIT17_10280 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VEIT17_10300 ENOG4105VEQ Cold shock protein VEIT17_10320 ENOG4105E5Q amino acid AbC transporter VEIT17_10330 ENOG4106PMH Extracellular solute-binding protein family 3 VEIT17_10340 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VEIT17_10350 ENOG4105MJ2 Competence protein VEIT17_10360 ENOG4105C7H Helicase, RecD TraA family VEIT17_10380 ENOG4105DTN riboflavin biosynthesis protein ribF VEIT17_10410 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) VEIT17_10420 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) VEIT17_10420 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) VEIT17_10430 ENOG4105VHM ribosomal protein VEIT17_10450 ENOG4105CHV Transcription elongation factor NusA VEIT17_10480 ENOG4107SC1 transglycosylase VEIT17_10490 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) VEIT17_10500 ENOG4105C2M dna polymerase I VEIT17_10530 ENOG4108RS6 transposase VEIT17_10540 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) VEIT17_10560 ENOG4108RS6 transposase VEIT17_10570 ENOG4108RS6 transposase VEIT17_10580 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) VEIT17_10590 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) VEIT17_10600 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) VEIT17_10610 ENOG4105D5T phosphonate abc transporter VEIT17_10620 ENOG4105C7J ABC transporter, permease VEIT17_10660 ENOG4105DFM M18 family aminopeptidase VEIT17_10670 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) VEIT17_10690 ENOG4105XA0 heptosyltransferase ii VEIT17_10700 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase VEIT17_10710 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) VEIT17_10720 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) VEIT17_10730 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VEIT17_10750 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) VEIT17_10770 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) VEIT17_10780 ENOG4105DFM M18 family aminopeptidase VEIT17_10790 ENOG4107QPK )-transporter VEIT17_10810 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEIT17_10840 ENOG4105CM2 brancheD-chain amino acid aminotransferase VEIT17_10860 ENOG4105ERH Fumarylacetoacetate hydrolase VEIT17_10930 ENOG4105DQ6 Transposase VEIT17_11030 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VEIT17_11040 ENOG4108ZCF integral membrane protein VEIT17_11050 ENOG4108ZCF integral membrane protein VEIT17_11060 ENOG4107QMU Mate efflux family protein VEIT17_11080 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) VEIT17_11090 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VEIT17_11100 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) VEIT17_11120 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) VEIT17_11130 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) VEIT17_11140 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VEIT17_11150 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) VEIT17_11160 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VEIT17_11170 ENOG4105EA8 2-Nitropropane dioxygenase VEIT17_11180 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VEIT17_11190 ENOG4105CHR reductase VEIT17_11200 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase VEIT17_11210 ENOG4105EA8 2-Nitropropane dioxygenase VEIT17_11220 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VEIT17_11230 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) VEIT17_11250 ENOG41067VY 50S ribosomal protein L32 VEIT17_11270 ENOG4105VCQ rubredoxin VEIT17_11310 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) VEIT17_11320 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase VEIT17_11440 ENOG4105KPE licD family VEIT17_11460 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VEIT17_11480 ENOG4105D75 Capsular exopolysaccharide family VEIT17_11510 ENOG4108IV0 ABC, transporter VEIT17_11520 ENOG4105C0Z ABC transporter VEIT17_11530 ENOG4105CF8 branched-chain amino acid ABC transporter, permease VEIT17_11540 ENOG4105C32 Amino acid ABC transporter (Permease) VEIT17_11550 ENOG4105CP9 extracellular ligand-binding receptor VEIT17_11560 ENOG4105C5H ABC transporter VEIT17_11570 ENOG4105E4G Type IV pilus VEIT17_11600 ENOG4105CMR udp-glucose 4-epimerase VEIT17_11610 ENOG4107QP8 phosphohexose isomerase VEIT17_11630 ENOG4105C1B dTDP-glucose 4-6-dehydratase VEIT17_11650 ENOG4108Z66 YbaK ebsC protein VEIT17_11670 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VEIT17_11690 ENOG4105VKD bioY protein VEIT17_11760 ENOG4105CQS hydrogenase expression formation protein HypD VEIT17_11790 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs VEIT17_11870 ENOG4105CE1 Ferrous iron transport protein b VEIT17_11890 ENOG4105C1J atp-dependent rna helicase VEIT17_11900 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VEIT17_11910 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) VEIT17_11920 ENOG4105D6U Sodium Glutamate Symporter VEIT17_11930 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) VEIT17_11940 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) VEIT17_11950 ENOG4107R11 Transcriptional regulator VEIT17_11970 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VEIT17_11980 ENOG41069ER domain protein VEIT17_11990 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) VEIT17_12020 ENOG4105F8V Hydrolase, tatD family VEIT17_12030 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) VEIT17_12040 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VEIT17_12060 ENOG4105MA4 psp1 domain protein VEIT17_12070 ENOG4107QMP dna polymerase iii subunits gamma and tau VEIT17_12080 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) VEIT17_12090 ENOG4105CXN decarboxylase VEIT17_12100 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) VEIT17_12120 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VEIT17_12130 ENOG4105DFT pur operon repressor VEIT17_12140 ENOG41069ER domain protein VEIT17_12150 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VEIT17_12160 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VEIT17_12180 ENOG4105X1Q TOBE domain protein VEIT17_12200 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEIT17_12210 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEIT17_12230 ENOG4105VIE preprotein translocase, subunit YajC VEIT17_12240 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) VEIT17_12260 ENOG4105JFG SpoIID LytB domain protein VEIT17_12280 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) VEIT17_12290 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) VEIT17_12310 ENOG4108WTY tRNA (Guanine-N(1)-)-methyltransferase VEIT17_12360 ENOG4105K4T epimerase VEIT17_12370 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) VEIT17_12380 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) VEIT17_12410 ENOG4105K5M 30s ribosomal protein S16 VEIT17_12440 ENOG4107QN2 dihydrolipoyl dehydrogenase VEIT17_12460 ENOG4105C59 p-type ATPase VEIT17_12470 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein VEIT17_12490 ENOG4108KSA LysR family transcriptional regulator VEIT17_12500 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) VEIT17_12510 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) VEIT17_12540 ENOG4105CD3 dihydroorotase VEIT17_12550 ENOG4105CXT aspartate transcarbamylase VEIT17_12570 ENOG4105CIE May be required for sporulation (By similarity) VEIT17_12600 ENOG410667J hydrolase VEIT17_12610 ENOG4105ZU5 s-layer protein VEIT17_12620 ENOG4105ZU5 s-layer protein VEIT17_12630 ENOG4105C3F Signal peptidase i VEIT17_12640 ENOG4108JYZ YitT family VEIT17_12660 ENOG4108R0D protein with myosin-like VEIT17_12680 ENOG4108IUZ ABC transporter VEIT17_12690 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) VEIT17_12730 ENOG4105C2X Arabinose 5-phosphate isomerase VEIT17_12740 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VEIT17_12750 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) VEIT17_12760 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) VEIT17_12770 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase VEIT17_12780 ENOG4105BZ1 (ABC) transporter VEIT17_12790 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEIT17_12810 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEIT17_12820 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VEIT17_12830 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEIT17_12840 ENOG4105D1S lipid A biosynthesis VEIT17_12850 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEIT17_12930 ENOG4105DHJ ABC, transporter VEIT17_12990 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) VEIT17_13000 ENOG4105CBT Fructose-1,6-bisphosphatase VEIT17_13010 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VEIT17_13040 ENOG4107QUY Guanine deaminase VEIT17_13050 ENOG4105CXN decarboxylase VEIT17_13060 ENOG4105CRK lysyL-tRNA synthetase VEIT17_13080 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VEIT17_13090 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) VEIT17_13120 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VEIT17_13140 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) VEIT17_13160 ENOG41060GV RNA binding s1 domain protein VEIT17_13180 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) VEIT17_13190 ENOG4107BMA Transglycosylase associated protein VEIT17_13210 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VEIT17_13220 ENOG4105KRF dihydroneopterin aldolase VEIT17_13230 ENOG4105EEI dihydropteroate synthase VEIT17_13240 ENOG4105EUJ GTP cyclohydrolase i VEIT17_13250 ENOG4105C5H ABC transporter VEIT17_13270 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VEIT17_13300 ENOG4108JQ7 (ABC) transporter VEIT17_13320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEIT17_13330 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEIT17_13360 ENOG4105DQ6 Transposase VEIT17_13390 ENOG4108JJ9 ABC, transporter VEIT17_13400 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VEIT17_13410 ENOG4105C4M (Ubiquinol oxidase) subunit I VEIT17_13430 ENOG4105EPU Molybdenum cofactor synthesis domain protein VEIT17_13440 ENOG4107BJW polysaccharide deacetylase VEIT17_13450 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) VEIT17_13470 ENOG4107ZE5 PPIases accelerate the folding of proteins VEIT17_13480 ENOG4105CUZ uba thif-type nad fad binding protein VEIT17_13500 ENOG4105EYH Exonuclease VEIT17_13510 ENOG4107RFY SbcCD D subunit VEIT17_13520 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) VEIT17_13530 ENOG4107XWZ ferric uptake regulator VEIT17_13540 ENOG4105C1J atp-dependent rna helicase VEIT17_13600 ENOG4105C26 Dehydrogenase VEIT17_13620 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) VEIT17_13630 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) VEIT17_13640 ENOG4105C9U ATP-dependent DNA helicase RecQ VEIT17_13650 ENOG4105CK7 Sodium proline symporter VEIT17_13670 ENOG4106R49 Methyltransferase VEIT17_13690 ENOG4107RSM transcriptional regulator VEIT17_13750 ENOG4105CHY citrate lyase, alpha VEIT17_13760 ENOG4105CI0 Citrate lyase VEIT17_13770 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) VEIT17_13780 ENOG4107QPK )-transporter VEIT17_13790 ENOG4108KAM Transcriptional regulator VEIT17_13800 ENOG4105HFZ Membrane VEIT17_13820 ENOG4105C0B DNA polymerase III (alpha subunit) VEIT17_13840 ENOG4108RS6 transposase VEIT17_13900 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase VEIT17_13910 ENOG4105D52 delta-aminolevulinic acid dehydratase VEIT17_13920 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VEIT17_13930 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) VEIT17_13940 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) VEIT17_13950 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VEIT17_13960 ENOG4105DBK s4 domain protein VEIT17_13980 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) VEIT17_13990 ENOG4105DFA alanine racemase domain protein VEIT17_14010 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VEIT17_14020 ENOG4107VMU Membrane VEIT17_14050 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase VEIT17_14060 ENOG4105DKW ABC transporter VEIT17_14080 ENOG4105C7K acetolactate synthase VEIT17_14090 ENOG4105C7B Threonine dehydratase VEIT17_14100 ENOG4105C01 Dihydroxy-acid dehydratase VEIT17_14120 ENOG4107QPK )-transporter VEIT17_14130 ENOG4105G2U Cupin 2, conserved barrel domain protein VEIT17_14150 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VEIT17_14160 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) VEIT17_14170 ENOG4105CGU Enoyl-CoA hydratase VEIT17_14190 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) VEIT17_14200 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) VEIT17_14210 ENOG4105DZ2 Transcriptional regulator VEIT17_14220 ENOG4105KK4 UPF0060 membrane protein VEIT17_14230 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VEIT17_14260 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VEIT17_14280 ENOG4105UQX Mate efflux family protein VEIT17_14310 ENOG4105DQU oxidoreductase, subunit beta VEIT17_14320 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein VEIT17_14330 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) VEIT17_14340 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) VEIT17_14350 ENOG4108JJB ABC transporter VEIT17_14360 ENOG4108JJB ABC transporter VEIT17_14370 ENOG4108ZT0 50S ribosomal protein l17 VEIT17_14380 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VEIT17_14390 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) VEIT17_14440 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) VEIT17_14450 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) VEIT17_14460 ENOG4105VPB 50S ribosomal protein L30 VEIT17_14470 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) VEIT17_14480 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) VEIT17_14500 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) VEIT17_14520 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits VEIT17_14540 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) VEIT17_14570 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) VEIT17_14580 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) VEIT17_14590 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) VEIT17_14600 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) VEIT17_14610 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity VEIT17_14630 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) VEIT17_14640 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) VEIT17_14650 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) VEIT17_14660 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VEIT17_14680 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) VEIT17_14690 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) VEIT17_14710 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VEIT17_14720 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VEIT17_14730 ENOG4108IJ0 Aspartate ammonia-lyase VEIT17_14740 ENOG4107SH3 glycosyl transferase, family 39 VEIT17_14760 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) VEIT17_14790 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) VEIT17_14800 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) VEIT17_14810 ENOG410683Z Preprotein translocase SecE subunit VEIT17_14820 ENOG4105WDJ 50S ribosomal protein L33 VEIT17_14830 ENOG4105DSQ Nitric oxide reductase VEIT17_14840 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VEIT17_14850 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) VEIT17_14880 ENOG4107RSS Hydrogenase accessory protein HypB VEIT17_14900 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) VEIT17_14910 ENOG4105CJN penicillin-binding protein VEIT17_14920 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate VEIT17_14930 ENOG4105EJQ L-serine dehydratase VEIT17_14950 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) VEIT17_15030 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) VEIT17_15060 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) VEIT17_15070 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VEIT17_15080 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) VEIT17_15090 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VEIT17_15100 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) VEIT17_15130 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase VEIT17_15140 ENOG4105ESV Glycosyl transferase, family 4 VEIT17_15150 ENOG4105CAG UPF0210 protein VEIT17_15160 ENOG4105VUC UPF0237 protein VEIT17_15170 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 VEIT17_15180 ENOG4108JYZ YitT family VEIT17_15190 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) VEIT17_15200 ENOG4105DRR Transcriptional regulator, GntR family VEIT17_15230 ENOG4105D82 Glutamate dehydrogenase VEIT17_15250 ENOG4105DQ6 Transposase VEIT17_15270 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) VEIT17_15280 ENOG4105CGK Exodeoxyribonuclease III VEIT17_15420 ENOG4105K4H Nlp p60 protein VEIT17_15430 ENOG4105K4H Nlp p60 protein VEIT17_15490 ENOG4106128 DNA-binding helix-turn-helix protein VEIT17_15500 ENOG4106BHR ftsk SpoIIIE family protein VEIT17_15520 ENOG4108RYM conjugative transposon protein VEIT17_15580 ENOG4107RRN ABC transporter substrate-binding protein VEIT17_15610 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein VEIT17_15620 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEIT17_15640 ENOG4105D5Q Arginine ornithine antiporter VEIT17_15650 ENOG4105CH7 arginosuccinase VEIT17_15660 ENOG4105CDH Citrulline--aspartate ligase VEIT17_15680 ENOG4108JQC penicillin-binding protein 1A VEIT17_15700 ENOG4105KRI phosphocarrier protein (HPr VEIT17_15710 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) VEIT17_15720 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) VEIT17_15730 ENOG4105DFD Na H antiporter VEIT17_15740 ENOG4105DE4 1-phosphofructokinase VEIT17_15750 ENOG4105DM4 PTS System VEIT17_15790 ENOG4105C6T cysteine synthase VEIT17_15800 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family VEIT17_15810 ENOG4105D3R alkyl hydroperoxide reductase VEIT17_15830 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) VEIT17_15840 ENOG4105C75 arginyL-tRNA synthetase VEIT17_15890 ENOG4108K4B hydrolase VEIT17_15930 ENOG4108J2R molybdopterin oxidoreductase VEIT17_15940 ENOG4105DG4 malate L-lactate dehydrogenase VEIT17_15970 ENOG4105C2C drug resistance transporter, Bcr CflA VEIT17_16000 ENOG4108EKI Dehydrogenase VEIT17_16010 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml VEIT17_16030 ENOG4107RWI ethanolamine utilization protein eutJ VEIT17_16040 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) VEIT17_16050 ENOG4105KNY Microcompartments protein VEIT17_16060 ENOG4105KNY Microcompartments protein VEIT17_16070 ENOG4105EHR propanediol utilization protein pduB VEIT17_16080 ENOG4105KNY Microcompartments protein VEIT17_16090 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VEIT17_16100 ENOG4105KTW ethanolamine utilization protein VEIT17_16110 ENOG4105M3W utilization protein VEIT17_16120 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VEIT17_16150 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit VEIT17_16160 ENOG4108ZFT Dehydratase small subunit VEIT17_16170 ENOG4105YCI dehydratase medium subunit VEIT17_16180 ENOG4105DMB glycerol dehydratase VEIT17_16190 ENOG4105EHR propanediol utilization protein pduB VEIT17_16200 ENOG4107XVH Transcriptional regulator VEIT17_16210 ENOG4105D01 (LipO)protein VEIT17_16230 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VEIT17_16300 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEIT17_16310 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEIT17_16360 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase VEIT17_16370 ENOG4105D49 3-dehydroquinate synthase VEIT17_16380 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase VEIT17_16390 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase VEIT17_16400 ENOG4105CQC Prephenate dehydratase VEIT17_16440 ENOG4105FF2 Type I DHQase VEIT17_16450 ENOG4105C6X Major Facilitator VEIT17_16460 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family VEIT17_16470 ENOG4105C7N Xanthine uracil vitamin C permease VEIT17_16530 ENOG4105C85 amino acid VEIT17_16560 ENOG4105C34 Pseudouridine synthase VEIT17_16600 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) VEIT17_16610 ENOG4105C6E dna polymerase iii VEIT17_16630 ENOG4105C34 Pseudouridine synthase VEIT17_16660 ENOG4107X8C Efflux transporter RND family MFP subunit VEIT17_16680 ENOG4105KMT branched-chain amino acid VEIT17_16690 ENOG4108UMN azlc family VEIT17_16700 ENOG4108I6A alcohol dehydrogenase VEIT17_16710 ENOG4105D01 (LipO)protein VEIT17_16720 ENOG4105DQ6 Transposase VEIT17_16740 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) VEIT17_16760 ENOG4107QZF nitrite reductase NADPH large subunit VEIT17_16780 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) VEIT17_16790 ENOG4107QR9 Iron-sulfur cluster binding protein VEIT17_16800 ENOG4107R5T Cysteine-rich domain VEIT17_16840 ENOG4105EPD Oligopeptide transporter, Opt family VEIT17_16890 ENOG4107RN3 metallophosphoesterase VEIT17_16960 ENOG4105WMR Protein CrcB homolog VEIT17_16990 ENOG4105CBD Diacylglycerol kinase VEIT17_17000 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation VEIT17_17010 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination VEIT17_17050 ENOG4105FCD Major Facilitator VEIT17_17190 ENOG4105CNA YD repeat protein VEIT17_17450 ENOG4105DQ6 Transposase VEIT17_17490 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VEIT17_17510 ENOG4105CDU Replicative dna helicase VEIT17_17530 ENOG4105BZR domain protein VEIT17_17580 ENOG4105CN5 Metallo-Beta-Lactamase VEIT17_17600 ENOG4105D7T ABC transporter VEIT17_17610 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VEIT17_17620 ENOG4107Z6I Thiamine biosynthesis protein VEIT17_17630 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) VEIT17_17640 ENOG4107T5V SNARE associated Golgi VEIT17_17670 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase VEIT17_17680 ENOG41086B8 CoB-CoM heterodisulfide reductase VEIT17_17690 ENOG4105E33 succinate dehydrogenase VEIT17_17700 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VEIT17_17710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VEIT17_17720 ENOG41062D9 Histidine kinase VEIT17_17730 ENOG4106BRA Membrane VEIT17_17740 ENOG4106BRA Membrane VEIT17_17760 ENOG4105KVH Transcriptional regulator VEIT17_17770 ENOG4108RYK Nad-dependent epimerase dehydratase VEIT17_17790 ENOG4108IJ2 phosphate acetyltransferase VEIT17_17800 ENOG4105E4P ATPase (AAA VEIT17_17830 ENOG4105BZ8 glutamate synthase VEIT17_17840 ENOG4105C87 Aminotransferase class I and II VEIT17_17900 ENOG4108W5N phosphatidylglycerophosphatase a VEIT17_17920 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA VEIT17_17930 ENOG4105VUF Transcriptional regulator VEIT17_18090 ENOG4108RS6 transposase VEIT17_18110 ENOG4105F9F transposase VEIT17_18140 ENOG4105CH6 catalase VEIT17_18160 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VEIT17_18190 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis VEIT17_18210 ENOG4105C83 adenylosuccinate lyase VEIT17_18230 ENOG4105C6K Malic enzyme VEIT17_18300 ENOG4105DJT lAO AO transport system ATPase VEIT17_18310 ENOG4105D5P Methylmalonyl-coA mutase VEIT17_18330 ENOG4105FR1 rard protein VEIT17_18390 ENOG4105CQB FAD linked oxidase domain protein VEIT17_18420 ENOG4105C0A alcohol dehydrogenase VEIT17_18490 ENOG4105K56 Transcriptional regulator VEIT17_18520 ENOG4105CXY transporter VEIT17_18530 ENOG4105CXY transporter VEIT17_18550 ENOG41080E8 Transcriptional regulator, Spx MgsR family VEIT17_18560 ENOG4105VDM plasmid maintenance system antidote protein, xre family VEIT17_18570 ENOG41080ET plasmid maintenance system killer protein VEIT17_18590 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VEIT17_18700 ENOG4107QN1 sodium solute VEIT17_18720 ENOG4105CEE C4-dicarboxylate transporter VEIT17_18730 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VEIT17_18810 ENOG4105DVF Cytosine-specific methyltransferase VEIT17_18860 ENOG4107QHI -hydrogenase VEIT17_18910 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEIT17_18920 ENOG4105E4P ATPase (AAA VEIT17_18950 ENOG4105PW4 Sugar fermentation stimulation protein homolog VEIT17_18980 ENOG4108IFG nitrite reductase, (NAD(P)H) VEIT17_19060 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP VEIT17_19070 ENOG4105E4C Lytic transglycosylase catalytic VEIT17_19090 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) VEIT17_19100 ENOG4105FA0 parb-like partition protein VEIT17_19110 ENOG4107QJE Chromosome Partitioning Protein VEIT17_19130 ENOG4105C3R Methionine synthase VEIT17_19150 ENOG4108RS6 transposase VEIT17_19160 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) VEIT17_19180 ENOG4105XMH SpoVT AbrB domain protein VEIT17_19190 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A VEIT17_19200 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VEIT17_19210 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VEIT17_19220 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein VEIT17_19230 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins VEIT17_19240 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) VEIT17_19250 ENOG4105VG0 50S ribosomal protein l34