locus-tag	class	description
GAY96_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GAY96_00010	COG0592	DNA-directed DNA polymerase activity
GAY96_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GAY96_00035	COG0751	glycine-tRNA ligase activity
GAY96_00040	COG0752	glycyl-tRNA synthetase alpha subunit
GAY96_00055	COG0745	RESPONSE REGULATOR receiver
GAY96_00060	COG1560	Kdo2-lipid A biosynthetic process
GAY96_00065	COG3263	regulation of cellular component size
GAY96_00070	COG0589	response to stress
GAY96_00075	COG0659	secondary active sulfate transmembrane transporter activity
GAY96_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GAY96_00085	COG0569	domain protein
GAY96_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GAY96_00100	COG0242	peptide deformylase activity
GAY96_00110	COG0758	DNA mediated transformation
GAY96_00115	COG0009	L-threonylcarbamoyladenylate synthase
GAY96_00120	COG0408	coproporphyrinogen oxidase activity
GAY96_00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GAY96_00150	COG0217	transcriptional regulatory protein
GAY96_00165	COG3609	addiction module antidote protein, CC2985 family
GAY96_00175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GAY96_00180	COG0339	signal peptide processing
GAY96_00205	COG0579	oxidoreductase
GAY96_00210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GAY96_00230	COG3038	cytochrome b561
GAY96_00235	COG0583	DNA-binding transcription factor activity
GAY96_00245	COG1404	Belongs to the peptidase S8 family
GAY96_00285	COG3437	response regulator, receiver
GAY96_00315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GAY96_00320	COG1349	DNA-binding transcription factor activity
GAY96_00335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GAY96_00350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GAY96_00355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GAY96_00360	COG1121	(ABC) transporter
GAY96_00365	COG0735	belongs to the Fur family
GAY96_00370	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GAY96_00375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GAY96_00380	COG1346	cytolysis
GAY96_00385	COG1380	Effector of murein hydrolase LrgA
GAY96_00395	COG0628	permease
GAY96_00400	COG0745	RESPONSE REGULATOR receiver
GAY96_00410	COG0281	malic enzyme
GAY96_00420	COG1217	gtp-binding protein TYPA
GAY96_00440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GAY96_00465	COG0006	proline dipeptidase activity
GAY96_00470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GAY96_00475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GAY96_00480	COG1607	acyl-coa hydrolase
GAY96_00500	COG0573	inorganic phosphate transmembrane transporter activity
GAY96_00505	COG0581	inorganic phosphate transmembrane transporter activity
GAY96_00510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GAY96_00525	COG5002	protein histidine kinase activity
GAY96_00550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GAY96_00575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GAY96_00580	COG3161	chorismate lyase activity
GAY96_00610	COG1301	dicarboxylic acid transport
GAY96_00635	COG2132	Multicopper oxidase
GAY96_00650	COG2050	protein possibly involved in aromatic compounds catabolism
GAY96_00660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GAY96_00665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GAY96_00670	COG0204	Acyl-transferase
GAY96_00675	COG2840	Smr protein MutS2
GAY96_00690	COG0318	PFAM AMP-dependent synthetase and ligase
GAY96_00700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GAY96_00705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GAY96_00705	COG2813	Specifically methylates the guanine in position
GAY96_00715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GAY96_00720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GAY96_00725	COG3642	lipopolysaccharide core region biosynthetic process
GAY96_00730	COG0859	PFAM glycosyl transferase family 9
GAY96_00740	COG0527	aspartate kinase activity
GAY96_00745	COG1917	Cupin 2, conserved barrel domain protein
GAY96_00780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GAY96_00790	COG0140	phosphoribosyl-ATP diphosphatase activity
GAY96_00795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GAY96_00800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GAY96_00825	COG1073	alpha beta
GAY96_00830	COG0659	secondary active sulfate transmembrane transporter activity
GAY96_00835	COG1872	DUF167
GAY96_00875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GAY96_00880	COG1129	ABC transporter
GAY96_00880	COG0842	Transport permease protein
GAY96_00885	COG0842	Transport permease protein
GAY96_00890	COG0348	domain, Protein
GAY96_00890	COG3901	Regulator of nitric oxide reductase transcription
GAY96_00895	COG4263	nitrous-oxide reductase activity
GAY96_00910	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GAY96_00920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GAY96_00930	COG1012	belongs to the aldehyde dehydrogenase family
GAY96_00940	COG0604	alcohol dehydrogenase
GAY96_00960	COG1283	sodium-dependent phosphate transmembrane transporter activity
GAY96_00965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GAY96_00970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GAY96_00970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GAY96_00975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GAY96_01000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GAY96_01020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GAY96_01025	COG0081	regulation of translation
GAY96_01030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GAY96_01035	COG0222	ribosome binding
GAY96_01040	COG0085	RNA polymerase activity
GAY96_01050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GAY96_01055	COG0049	tRNA binding
GAY96_01060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GAY96_01065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GAY96_01075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GAY96_01080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GAY96_01090	COG0051	transcription antitermination factor activity, RNA binding
GAY96_01095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GAY96_01100	COG0088	Forms part of the polypeptide exit tunnel
GAY96_01105	COG0089	rRNA binding
GAY96_01110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GAY96_01115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GAY96_01120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GAY96_01125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GAY96_01135	COG0255	Belongs to the universal ribosomal protein uL29 family
GAY96_01140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GAY96_01145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GAY96_01150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GAY96_01155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GAY96_01160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GAY96_01165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GAY96_01170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GAY96_01175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GAY96_01180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GAY96_01185	COG1841	ribosomal large subunit assembly
GAY96_01190	COG0200	Binds to the 23S rRNA
GAY96_01200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GAY96_01205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GAY96_01210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GAY96_01215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GAY96_01220	COG0202	RNA polymerase activity
GAY96_01225	COG0203	ribosomal protein L17
GAY96_01250	COG2771	luxR family
GAY96_01250	COG2200	EAL domain
GAY96_01255	COG2204	response regulator
GAY96_01265	COG1294	oxidase, subunit
GAY96_01270	COG4890	Cyd operon protein YbgT
GAY96_01275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GAY96_01290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GAY96_01290	COG2111	Na H antiporter
GAY96_01295	COG1006	Multisubunit Na H antiporter MnhC subunit
GAY96_01300	COG0651	ATP synthesis coupled electron transport
GAY96_01305	COG1863	multisubunit Na H antiporter MnhE subunit
GAY96_01310	COG2212	antiporter activity
GAY96_01315	COG1320	monovalent cation:proton antiporter activity
GAY96_01325	COG2873	o-acetylhomoserine
GAY96_01340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GAY96_01350	COG1360	Flagellar Motor Protein
GAY96_01355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GAY96_01360	COG1722	exodeoxyribonuclease VII activity
GAY96_01365	COG0142	geranyltranstransferase activity
GAY96_01375	COG3852	Histidine kinase
GAY96_01380	COG2204	response regulator
GAY96_01385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GAY96_01390	COG2738	Putative neutral zinc metallopeptidase
GAY96_01400	COG0798	PFAM Bile acid sodium symporter
GAY96_01405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GAY96_01415	COG1064	alcohol dehydrogenase
GAY96_01440	COG0745	RESPONSE REGULATOR receiver
GAY96_01460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GAY96_01480	COG4181	ATPase activity
GAY96_01485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GAY96_01490	COG0523	cobalamin synthesis protein
GAY96_01500	COG1597	lipid kinase activity
GAY96_01530	COG0348	domain, Protein
GAY96_01535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GAY96_01540	COG2267	carboxylic ester hydrolase activity
GAY96_01555	COG1238	metal cluster binding
GAY96_01565	COG1187	pseudouridine synthase activity
GAY96_01610	COG2267	carboxylic ester hydrolase activity
GAY96_01625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GAY96_01640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GAY96_01650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GAY96_01665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GAY96_01665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GAY96_01670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GAY96_01680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GAY96_01690	COG0488	(ABC) transporter
GAY96_01700	COG0179	Fumarylacetoacetate (FAA) hydrolase
GAY96_01705	COG0629	single-stranded DNA binding
GAY96_01710	COG2814	Major facilitator Superfamily
GAY96_01715	COG2197	response regulator
GAY96_01745	COG0560	Phosphoserine phosphatase
GAY96_01745	COG3830	Belongs to the UPF0237 family
GAY96_01760	COG0688	phosphatidylethanolamine metabolic process
GAY96_01780	COG1360	Flagellar Motor Protein
GAY96_01785	COG1162	GTPase activity
GAY96_01805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GAY96_01805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GAY96_01810	COG0802	atpase or kinase
GAY96_01820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GAY96_01825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GAY96_01830	COG1923	regulation of RNA biosynthetic process
GAY96_01835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GAY96_01840	COG0330	HflC and HflK could
GAY96_01845	COG0330	HflC and HflK could
GAY96_01855	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GAY96_01860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GAY96_01870	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GAY96_01875	COG0235	Class ii aldolase
GAY96_01880	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GAY96_01890	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GAY96_01895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GAY96_01900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GAY96_01905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GAY96_01910	COG0617	tRNA 3'-terminal CCA addition
GAY96_01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GAY96_01935	COG1489	DNA binding
GAY96_01940	COG0436	Aminotransferase
GAY96_01955	COG4191	Histidine kinase
GAY96_01980	COG0417	DNA replication proofreading
GAY96_01990	COG3148	PFAM DTW domain containing protein
GAY96_02000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GAY96_02020	COG0793	Belongs to the peptidase S41A family
GAY96_02025	COG4942	peptidase
GAY96_02030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GAY96_02035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GAY96_02040	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GAY96_02045	COG2133	pyrroloquinoline quinone binding
GAY96_02050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GAY96_02070	COG2204	response regulator
GAY96_02075	COG3852	Histidine kinase
GAY96_02085	COG3094	Invasion gene expression up-regulator, SirB
GAY96_02100	COG2119	membrane
GAY96_02125	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GAY96_02145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GAY96_02150	COG0671	phosphoesterase, PA-phosphatase related
GAY96_02200	COG0579	oxidoreductase
GAY96_02230	COG0438	transferase activity, transferring glycosyl groups
GAY96_02235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GAY96_02240	COG2951	lytic endotransglycosylase activity
GAY96_02245	COG0772	Belongs to the SEDS family
GAY96_02250	COG0768	penicillin binding
GAY96_02255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GAY96_02270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GAY96_02280	COG3300	MHYT domain
GAY96_02280	COG5001	Diguanylate cyclase
GAY96_02300	COG3012	SEC-C Motif Domain Protein
GAY96_02315	COG1686	Belongs to the peptidase S11 family
GAY96_02320	COG2921	Belongs to the UPF0250 family
GAY96_02325	COG0321	lipoyl(octanoyl) transferase activity
GAY96_02340	COG3118	belongs to the thioredoxin family
GAY96_02350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GAY96_02360	COG0142	geranyltranstransferase activity
GAY96_02365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GAY96_02375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GAY96_02380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GAY96_02385	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GAY96_02390	COG0268	Binds directly to 16S ribosomal RNA
GAY96_02395	COG0728	peptidoglycan biosynthetic process
GAY96_02400	COG0196	riboflavin kinase activity
GAY96_02405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GAY96_02415	COG1047	Peptidyl-prolyl cis-trans
GAY96_02420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GAY96_02455	COG4968	Prepilin-type N-terminal cleavage methylation domain
GAY96_02470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GAY96_02470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GAY96_02495	COG0028	Belongs to the TPP enzyme family
GAY96_02510	COG1272	protein, Hemolysin III
GAY96_02515	COG2827	Endonuclease containing a URI domain
GAY96_02545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GAY96_02590	COG1611	Belongs to the LOG family
GAY96_02595	COG2239	Acts as a magnesium transporter
GAY96_02600	COG0004	ammonium transporteR
GAY96_02610	COG0788	formyltetrahydrofolate deformylase activity
GAY96_02615	COG0183	Belongs to the thiolase family
GAY96_02635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GAY96_02640	COG1040	competence protein
GAY96_02655	COG1960	acyl-CoA dehydrogenase activity
GAY96_02660	COG1960	acyl-CoA dehydrogenase activity
GAY96_02690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GAY96_02695	COG0134	indole-3-glycerol-phosphate synthase activity
GAY96_02705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GAY96_02715	COG0784	Response regulator, receiver
GAY96_02715	COG3437	response regulator, receiver
GAY96_02725	COG1765	OsmC-like protein
GAY96_02730	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GAY96_02745	COG2813	Specifically methylates the guanine in position
GAY96_02750	COG0789	Transcriptional regulator
GAY96_02755	COG2202	Pas domain
GAY96_02755	COG1366	Belongs to the anti-sigma-factor antagonist family
GAY96_02775	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GAY96_02780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GAY96_02825	COG1466	dna polymerase III delta subunit
GAY96_02830	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GAY96_02835	COG0495	leucyl-tRNA aminoacylation
GAY96_02850	COG0840	transmembrane signaling receptor activity
GAY96_02855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GAY96_02860	COG2197	response regulator
GAY96_02865	COG0583	DNA-binding transcription factor activity
GAY96_02890	COG4221	oxidoreductase activity
GAY96_02905	COG0415	Belongs to the DNA photolyase family
GAY96_02910	COG0789	Transcriptional regulator
GAY96_02925	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GAY96_02930	COG1960	acyl-CoA dehydrogenase activity
GAY96_02935	COG1090	epimerase
GAY96_02955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GAY96_02965	COG0069	glutamate synthase activity
GAY96_02985	COG2096	Adenosyltransferase
GAY96_02995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GAY96_03005	COG1666	GTP binding
GAY96_03010	COG2211	Major facilitator Superfamily
GAY96_03015	COG1940	carbohydrate kinase activity
GAY96_03030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GAY96_03040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GAY96_03050	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GAY96_03060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GAY96_03065	COG3258	Cytochrome c
GAY96_03080	COG0783	Belongs to the Dps family
GAY96_03105	COG3852	Histidine kinase
GAY96_03110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GAY96_03115	COG0028	Belongs to the TPP enzyme family
GAY96_03120	COG1304	FMN binding
GAY96_03130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GAY96_03140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GAY96_03145	COG0733	neurotransmitter:sodium symporter activity
GAY96_03155	COG2914	Belongs to the UPF0125 (RnfH) family
GAY96_03170	COG0497	DNA recombination
GAY96_03175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GAY96_03180	COG0443	Heat shock 70 kDa protein
GAY96_03185	COG0484	heat shock protein binding
GAY96_03190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GAY96_03215	COG1607	acyl-coa hydrolase
GAY96_03220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GAY96_03235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GAY96_03240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GAY96_03245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GAY96_03250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GAY96_03255	COG0149	triose-phosphate isomerase activity
GAY96_03270	COG0779	Required for maturation of 30S ribosomal subunits
GAY96_03275	COG0195	Participates in both transcription termination and antitermination
GAY96_03280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GAY96_03285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GAY96_03290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GAY96_03300	COG1185	polyribonucleotide nucleotidyltransferase activity
GAY96_03310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GAY96_03315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GAY96_03335	COG3695	enzyme binding
GAY96_03345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GAY96_03350	COG1960	acyl-CoA dehydrogenase activity
GAY96_03355	COG0183	Belongs to the thiolase family
GAY96_03360	COG1250	3-hydroxyacyl-CoA dehydrogenase
GAY96_03360	COG1024	Enoyl-CoA hydratase
GAY96_03390	COG0193	aminoacyl-tRNA hydrolase activity
GAY96_03395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GAY96_03410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GAY96_03415	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GAY96_03425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GAY96_03430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GAY96_03435	COG2890	protein-(glutamine-N5) methyltransferase activity
GAY96_03440	COG0446	pyridine nucleotide-disulphide oxidoreductase
GAY96_03450	COG0792	nuclease activity
GAY96_03490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GAY96_03495	COG2207	Transcriptional regulator
GAY96_03505	COG0500	methyltransferase
GAY96_03575	COG0811	peptide transport
GAY96_03580	COG0811	peptide transport
GAY96_03585	COG0848	biopolymer transport protein
GAY96_03590	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GAY96_03610	COG2937	Belongs to the GPAT DAPAT family
GAY96_03615	COG2900	Belongs to the SlyX family
GAY96_03650	COG0105	UTP biosynthetic process
GAY96_03655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GAY96_03670	COG0124	histidyl-tRNA synthetase
GAY96_03675	COG2976	Protein conserved in bacteria
GAY96_03685	COG1160	GTP binding
GAY96_03700	COG1024	Enoyl-CoA hydratase
GAY96_03705	COG1960	acyl-CoA dehydrogenase activity
GAY96_03715	COG2832	Protein of unknown function (DUF454)
GAY96_03730	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GAY96_03745	COG4771	TonB-dependent receptor
GAY96_03765	COG2703	oxygen carrier activity
GAY96_03770	COG0471	metal ion transport
GAY96_03775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GAY96_03775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GAY96_03780	COG4536	flavin adenine dinucleotide binding
GAY96_03790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GAY96_03795	COG2862	Uncharacterized protein family, UPF0114
GAY96_03800	COG3781	membrane
GAY96_03835	COG2193	ferroxidase activity
GAY96_03860	COG2084	Dehydrogenase
GAY96_03865	COG3622	Belongs to the hyi family
GAY96_03870	COG3313	Fe-S protein
GAY96_03880	COG3706	GGDEF domain
GAY96_03885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GAY96_03890	COG0346	lactoylglutathione lyase activity
GAY96_03910	COG2171	N-acyltransferase activity
GAY96_03915	COG1393	Belongs to the ArsC family
GAY96_03935	COG1918	ferrous iron import across plasma membrane
GAY96_03935	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GAY96_03950	COG2264	protein methyltransferase activity
GAY96_03955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GAY96_03960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GAY96_03965	COG1192	Involved in chromosome partitioning
GAY96_03970	COG0084	hydrolase, TatD family'
GAY96_03985	COG0741	lytic transglycosylase activity
GAY96_03990	COG2264	protein methyltransferase activity
GAY96_04005	COG0776	regulation of translation
GAY96_04035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GAY96_04045	COG0438	transferase activity, transferring glycosyl groups
GAY96_04065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GAY96_04075	COG0438	transferase activity, transferring glycosyl groups
GAY96_04085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GAY96_04100	COG2244	polysaccharide biosynthetic process
GAY96_04105	COG0626	cystathionine gamma-synthase activity
GAY96_04120	COG0438	transferase activity, transferring glycosyl groups
GAY96_04130	COG1215	transferase activity, transferring glycosyl groups
GAY96_04135	COG1215	transferase activity, transferring glycosyl groups
GAY96_04145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GAY96_04155	COG2246	polysaccharide biosynthetic process
GAY96_04160	COG3039	Transposase
GAY96_04205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GAY96_04205	COG2755	lipolytic protein G-D-S-L family
GAY96_04215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GAY96_04215	COG2755	lipolytic protein G-D-S-L family
GAY96_04220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GAY96_04235	COG1024	Enoyl-CoA hydratase
GAY96_04240	COG0583	DNA-binding transcription factor activity
GAY96_04250	COG1741	Belongs to the pirin family
GAY96_04270	COG0676	glucose-6-phosphate 1-epimerase activity
GAY96_04280	COG0717	Belongs to the dCTP deaminase family
GAY96_04305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GAY96_04325	COG3243	poly(R)-hydroxyalkanoic acid synthase
GAY96_04360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GAY96_04375	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GAY96_04385	COG1793	dna ligase
GAY96_04400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GAY96_04430	COG0316	Belongs to the HesB IscA family
GAY96_04435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GAY96_04440	COG0719	Fe-S assembly protein
GAY96_04445	COG0396	ATPase activity
GAY96_04450	COG0719	Fe-S assembly protein
GAY96_04465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GAY96_04475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GAY96_04480	COG2252	PERMEase
GAY96_04515	COG1393	Belongs to the ArsC family
GAY96_04520	COG1295	ribonuclease BN
GAY96_04535	COG0033	Phosphoglucomutase
GAY96_04550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GAY96_04555	COG3112	Uncharacterised protein family (UPF0231)
GAY96_04560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GAY96_04565	COG0418	dihydroorotase activity
GAY96_04575	COG0137	argininosuccinate synthase activity
GAY96_04585	COG1451	nucleotide metabolic process
GAY96_04600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GAY96_04620	COG2198	Histidine kinase
GAY96_04620	COG2205	protein histidine kinase activity
GAY96_04620	COG0784	Response regulator, receiver
GAY96_04640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GAY96_04655	COG2095	MarC family integral membrane protein
GAY96_04670	COG0681	Belongs to the peptidase S26 family
GAY96_04680	COG0429	hydrolase of the alpha beta-hydrolase fold
GAY96_04685	COG2169	Transcriptional regulator
GAY96_04720	COG1596	polysaccharide export
GAY96_04720	COG1555	photosystem II stabilization
GAY96_04740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GAY96_04745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GAY96_04750	COG0705	Rhomboid family
GAY96_04765	COG0308	aminopeptidase N
GAY96_04835	COG0488	(ABC) transporter
GAY96_04850	COG1250	3-hydroxyacyl-CoA dehydrogenase
GAY96_04850	COG1024	Enoyl-CoA hydratase
GAY96_04855	COG0183	Belongs to the thiolase family
GAY96_04870	COG0840	transmembrane signaling receptor activity
GAY96_04875	COG2860	membrane
GAY96_04895	COG3115	cell septum assembly
GAY96_04895	COG3115	cell septum assembly
GAY96_04900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GAY96_04905	COG1858	cytochrome C peroxidase
GAY96_04920	COG2304	oxidoreductase activity
GAY96_04935	COG0714	Associated with various cellular activities
GAY96_04955	COG3130	regulation of translation
GAY96_04990	COG0307	riboflavin synthase, alpha
GAY96_05005	COG1643	Atp-dependent helicase
GAY96_05025	COG1028	Short-chain dehydrogenase reductase Sdr
GAY96_05030	COG0183	Belongs to the thiolase family
GAY96_05035	COG0425	Belongs to the sulfur carrier protein TusA family
GAY96_05040	COG0793	Belongs to the peptidase S41A family
GAY96_05050	COG0583	DNA-binding transcription factor activity
GAY96_05075	COG0632	four-way junction helicase activity
GAY96_05080	COG2255	four-way junction helicase activity
GAY96_05085	COG0824	Thioesterase
GAY96_05105	COG0823	Involved in the tonB-independent uptake of proteins
GAY96_05115	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GAY96_05130	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GAY96_05135	COG4783	chaperone-mediated protein folding
GAY96_05140	COG0425	Belongs to the sulfur carrier protein TusA family
GAY96_05150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GAY96_05160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GAY96_05165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GAY96_05185	COG0545	Peptidyl-prolyl cis-trans isomerase
GAY96_05200	COG0363	glucosamine-6-phosphate deaminase activity
GAY96_05210	COG0800	Aldolase
GAY96_05245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GAY96_05260	COG2022	thiamine diphosphate biosynthetic process
GAY96_05265	COG0352	thiamine-phosphate diphosphorylase activity
GAY96_05270	COG0326	Molecular chaperone. Has ATPase activity
GAY96_05295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GAY96_05325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GAY96_05335	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GAY96_05340	COG1805	sodium ion transport
GAY96_05355	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GAY96_05370	COG0300	oxidoreductase activity
GAY96_05385	COG0778	Nitroreductase
GAY96_05390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GAY96_05395	COG0795	lipopolysaccharide-transporting ATPase activity
GAY96_05400	COG0795	lipopolysaccharide-transporting ATPase activity
GAY96_05410	COG0259	pyridoxamine-phosphate oxidase activity
GAY96_05415	COG3001	Fructosamine kinase
GAY96_05430	COG0175	sulfate reduction
GAY96_05435	COG2945	thiolester hydrolase activity
GAY96_05440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GAY96_05450	COG0300	oxidoreductase activity
GAY96_05455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GAY96_05460	COG5001	Diguanylate cyclase
GAY96_05460	COG4251	negative regulation of phosphorylation
GAY96_05460	COG3706	GGDEF domain
GAY96_05460	COG2203	Gaf domain
GAY96_05465	COG3290	protein histidine kinase activity
GAY96_05465	COG0840	transmembrane signaling receptor activity
GAY96_05490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GAY96_05495	COG0343	queuine tRNA-ribosyltransferase activity
GAY96_05500	COG1862	Preprotein translocase
GAY96_05515	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GAY96_05540	COG0386	Belongs to the glutathione peroxidase family
GAY96_05570	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GAY96_05575	COG0525	valine-tRNA ligase activity
GAY96_05645	COG0525	valine-tRNA ligase activity
GAY96_05660	COG2226	methyltransferase
GAY96_05665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GAY96_05670	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GAY96_05695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GAY96_05705	COG0564	pseudouridine synthase activity
GAY96_05730	COG3323	Protein of unknown function (DUF1653)
GAY96_05730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GAY96_05750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GAY96_05755	COG5001	Diguanylate cyclase
GAY96_05755	COG4251	negative regulation of phosphorylation
GAY96_05755	COG3706	GGDEF domain
GAY96_05755	COG2203	Gaf domain
GAY96_05760	COG0789	Transcriptional regulator
GAY96_05780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GAY96_05790	COG3239	Fatty acid desaturase
GAY96_05795	COG0318	PFAM AMP-dependent synthetase and ligase
GAY96_05805	COG1960	acyl-CoA dehydrogenase activity
GAY96_05815	COG3047	cAMP biosynthetic process
GAY96_05820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GAY96_05825	COG0302	gtp cyclohydrolase
GAY96_05835	COG3706	GGDEF domain
GAY96_05870	COG0640	Transcriptional regulator
GAY96_05885	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GAY96_05900	COG0271	Belongs to the BolA IbaG family
GAY96_05910	COG2885	chlorophyll binding
GAY96_05930	COG0484	heat shock protein binding
GAY96_05935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GAY96_05945	COG0037	tRNA processing
GAY96_05950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GAY96_05965	COG2217	Heavy metal translocating P-type atpase
GAY96_05980	COG2010	Cytochrome c
GAY96_05995	COG3278	Belongs to the heme-copper respiratory oxidase family
GAY96_06005	COG4771	TonB-dependent receptor
GAY96_06025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GAY96_06050	COG3228	Belongs to the MtfA family
GAY96_06055	COG4977	sequence-specific DNA binding
GAY96_06060	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GAY96_06065	COG2837	iron assimilation
GAY96_06070	COG1335	isochorismatase
GAY96_06075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GAY96_06080	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GAY96_06085	COG1187	pseudouridine synthase activity
GAY96_06090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GAY96_06100	COG0189	ligase activity
GAY96_06130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAY96_06140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GAY96_06145	COG0204	Acyl-transferase
GAY96_06155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GAY96_06160	COG3177	Filamentation induced by cAMP protein fic
GAY96_06165	COG1049	propionate catabolic process, 2-methylcitrate cycle
GAY96_06170	COG0243	molybdopterin cofactor binding
GAY96_06175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GAY96_06200	COG0436	Aminotransferase
GAY96_06205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GAY96_06210	COG0386	Belongs to the glutathione peroxidase family
GAY96_06215	COG1846	Transcriptional regulator
GAY96_06255	COG3263	regulation of cellular component size
GAY96_06275	COG0745	RESPONSE REGULATOR receiver
GAY96_06285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GAY96_06295	COG0406	alpha-ribazole phosphatase activity
GAY96_06315	COG0826	peptidase U32
GAY96_06350	COG0589	response to stress
GAY96_06360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GAY96_06365	COG0066	3-isopropylmalate dehydratase activity
GAY96_06370	COG0473	3-isopropylmalate dehydrogenase activity
GAY96_06385	COG0101	tRNA pseudouridine synthase activity
GAY96_06390	COG0135	phosphoribosylanthranilate isomerase activity
GAY96_06395	COG0133	tryptophan synthase activity
GAY96_06400	COG0159	tryptophan synthase activity
GAY96_06405	COG0285	dihydrofolate synthase activity
GAY96_06415	COG1286	toxin biosynthetic process
GAY96_06435	COG0714	Associated with various cellular activities
GAY96_06455	COG3118	belongs to the thioredoxin family
GAY96_06460	COG0667	Aldo Keto reductase
GAY96_06490	COG5265	(ABC) transporter
GAY96_06495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GAY96_06500	COG0824	Thioesterase
GAY96_06525	COG2205	protein histidine kinase activity
GAY96_06525	COG2198	Histidine kinase
GAY96_06525	COG0784	Response regulator, receiver
GAY96_06530	COG1067	ATP-dependent peptidase activity
GAY96_06545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GAY96_06550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GAY96_06555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GAY96_06565	COG3100	YcgL domain-containing protein
GAY96_06570	COG2983	Belongs to the UPF0260 family
GAY96_06590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GAY96_06650	COG2030	dehydratase
GAY96_06655	COG2267	carboxylic ester hydrolase activity
GAY96_06660	COG0318	PFAM AMP-dependent synthetase and ligase
GAY96_06665	COG1643	Atp-dependent helicase
GAY96_06670	COG2853	Lipoprotein
GAY96_06680	COG0616	signal peptide processing
GAY96_06690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GAY96_06695	COG0584	glycerophosphoryl diester phosphodiesterase
GAY96_06700	COG0534	Mate efflux family protein
GAY96_06710	COG0316	Belongs to the HesB IscA family
GAY96_06710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GAY96_06780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GAY96_06805	COG1309	transcriptional regulator
GAY96_06820	COG1028	Short-chain dehydrogenase reductase Sdr
GAY96_06825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GAY96_06825	COG0301	tRNA thio-modification
GAY96_06835	COG0708	Exodeoxyribonuclease III
GAY96_06850	COG0848	biopolymer transport protein
GAY96_06855	COG0811	peptide transport
GAY96_06860	COG0811	peptide transport
GAY96_06890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GAY96_06895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GAY96_06900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GAY96_06905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GAY96_06910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GAY96_06920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GAY96_06925	COG0416	fatty acid biosynthetic process
GAY96_06930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GAY96_06935	COG1399	metal-binding, possibly nucleic acid-binding protein
GAY96_06940	COG0616	signal peptide processing
GAY96_06945	COG0546	phosphoglycolate phosphatase activity
GAY96_06950	COG0564	pseudouridine synthase activity
GAY96_06955	COG1530	ribonuclease E activity
GAY96_06965	COG2828	Protein conserved in bacteria
GAY96_06975	COG0372	Belongs to the citrate synthase family
GAY96_06980	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GAY96_06985	COG2186	Transcriptional regulator
GAY96_07005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GAY96_07045	COG0560	Phosphoserine phosphatase
GAY96_07090	COG2197	response regulator
GAY96_07100	COG0123	including yeast histone deacetylase and acetoin utilization protein
GAY96_07110	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GAY96_07125	COG2920	part of a sulfur-relay system
GAY96_07130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GAY96_07145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GAY96_07150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GAY96_07155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GAY96_07160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GAY96_07170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GAY96_07175	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GAY96_07180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GAY96_07185	COG0542	response to heat
GAY96_07190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GAY96_07195	COG1278	Cold shock
GAY96_07220	COG2915	High frequency lysogenization protein hflD homolog
GAY96_07230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GAY96_07245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GAY96_07255	COG1477	protein flavinylation
GAY96_07260	COG0640	Transcriptional regulator
GAY96_07295	COG0741	lytic transglycosylase activity
GAY96_07295	COG1388	LysM domain
GAY96_07310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GAY96_07320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GAY96_07325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GAY96_07330	COG0740	serine-type endopeptidase activity
GAY96_07335	COG0544	peptidyl-prolyl cis-trans isomerase activity
GAY96_07355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GAY96_07360	COG0215	cysteine-tRNA ligase activity
GAY96_07365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GAY96_07370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GAY96_07375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GAY96_07385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GAY96_07390	COG2835	tetraacyldisaccharide 4'-kinase activity
GAY96_07395	COG1663	tetraacyldisaccharide 4'-kinase activity
GAY96_07400	COG1132	(ABC) transporter
GAY96_07405	COG0848	biopolymer transport protein
GAY96_07410	COG0811	peptide transport
GAY96_07430	COG4591	ABC-type transport system involved in lipoprotein release permease component
GAY96_07445	COG1199	ATP-dependent helicase activity
GAY96_07455	COG3267	Type II secretory pathway component ExeA
GAY96_07455	COG3409	Peptidoglycan-binding domain 1 protein
GAY96_07470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GAY96_07490	COG2850	peptidyl-arginine hydroxylation
GAY96_07500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GAY96_07505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GAY96_07525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GAY96_07550	COG0842	Transport permease protein
GAY96_07555	COG1131	(ABC) transporter
GAY96_07600	COG1053	succinate dehydrogenase
GAY96_07605	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GAY96_07620	COG2084	Dehydrogenase
GAY96_07625	COG3217	Mosc domain protein beta barrel domain protein
GAY96_07625	COG0633	Ferredoxin
GAY96_07630	COG0835	chemotaxis
GAY96_07630	COG0784	Response regulator, receiver
GAY96_07635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GAY96_07640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GAY96_07655	COG0439	Biotin carboxylase
GAY96_07660	COG1944	ATP diphosphatase activity
GAY96_07680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GAY96_07685	COG1074	ATP-dependent DNA helicase activity
GAY96_07690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GAY96_07705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GAY96_07710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GAY96_07715	COG1116	anion transmembrane transporter activity
GAY96_07720	COG3707	response regulator
GAY96_07730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GAY96_07740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GAY96_07745	COG0243	molybdopterin cofactor binding
GAY96_07770	COG2818	Glycosylase
GAY96_07780	COG0442	prolyl-tRNA aminoacylation
GAY96_07785	COG0741	lytic transglycosylase activity
GAY96_07790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GAY96_07805	COG0732	type I restriction modification DNA specificity domain
GAY96_07865	COG0446	pyridine nucleotide-disulphide oxidoreductase
GAY96_07865	COG1902	pentaerythritol trinitrate reductase activity
GAY96_07870	COG0489	protein tyrosine kinase activity
GAY96_07885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GAY96_07890	COG0601	transmembrane transport
GAY96_07900	COG4657	Part of a membrane complex involved in electron transport
GAY96_07905	COG2878	Part of a membrane complex involved in electron transport
GAY96_07910	COG4656	Part of a membrane complex involved in electron transport
GAY96_07915	COG4658	electron transport chain
GAY96_07920	COG4659	FMN binding
GAY96_07925	COG4660	Part of a membrane complex involved in electron transport
GAY96_07940	COG1054	Belongs to the UPF0176 family
GAY96_07950	COG0545	Peptidyl-prolyl cis-trans isomerase
GAY96_07960	COG3268	Saccharopine dehydrogenase
GAY96_07970	COG1278	Cold shock
GAY96_07995	COG3093	addiction module antidote protein HigA
GAY96_08025	COG0519	Catalyzes the synthesis of GMP from XMP
GAY96_08025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GAY96_08055	COG0739	heme binding
GAY96_08075	COG1946	Acyl-CoA thioesterase
GAY96_08080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GAY96_08085	COG0513	Belongs to the DEAD box helicase family
GAY96_08090	COG0730	response to heat
GAY96_08095	COG0668	transmembrane transport
GAY96_08115	COG3174	membrane
GAY96_08120	COG0659	secondary active sulfate transmembrane transporter activity
GAY96_08125	COG2925	Exonuclease
GAY96_08130	COG2267	carboxylic ester hydrolase activity
GAY96_08150	COG3022	response to hydroperoxide
GAY96_08160	COG1960	acyl-CoA dehydrogenase activity
GAY96_08165	COG1960	acyl-CoA dehydrogenase activity
GAY96_08170	COG0318	PFAM AMP-dependent synthetase and ligase
GAY96_08175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GAY96_08185	COG3122	Protein conserved in bacteria
GAY96_08195	COG0577	efflux transmembrane transporter activity
GAY96_08195	COG1136	(ABC) transporter
GAY96_08200	COG0577	efflux transmembrane transporter activity
GAY96_08200	COG1136	(ABC) transporter
GAY96_08205	COG0577	efflux transmembrane transporter activity
GAY96_08205	COG1136	(ABC) transporter
GAY96_08220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GAY96_08230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GAY96_08240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GAY96_08255	COG3177	Filamentation induced by cAMP protein fic
GAY96_08320	COG0776	regulation of translation
GAY96_08325	COG0072	phenylalanine-tRNA ligase activity
GAY96_08330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GAY96_08335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GAY96_08340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GAY96_08345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GAY96_08350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GAY96_08365	COG0693	protein deglycase activity
GAY96_08370	COG0521	Mo-molybdopterin cofactor biosynthetic process
GAY96_08375	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GAY96_08385	COG3604	Transcriptional regulator
GAY96_08400	COG2197	response regulator
GAY96_08405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GAY96_08410	COG0746	molybdenum cofactor guanylyltransferase activity
GAY96_08415	COG0521	Mo-molybdopterin cofactor biosynthetic process
GAY96_08420	COG0315	cyclic pyranopterin monophosphate synthase activity
GAY96_08425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GAY96_08430	COG0314	molybdopterin synthase activity
GAY96_08455	COG2223	nitrite transmembrane transporter activity
GAY96_08465	COG2223	nitrite transmembrane transporter activity
GAY96_08475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GAY96_08480	COG2181	nitrate reductase activity
GAY96_08485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GAY96_08490	COG1140	nitrate reductase beta subunit
GAY96_08495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GAY96_08500	COG3850	Histidine kinase
GAY96_08525	COG4771	TonB-dependent receptor
GAY96_08530	COG0714	Associated with various cellular activities
GAY96_08535	COG2010	Cytochrome c
GAY96_08540	COG3256	nitric oxide reductase
GAY96_08575	COG0826	peptidase U32
GAY96_08580	COG0826	peptidase U32
GAY96_08585	COG3154	lipid carrier protein
GAY96_08600	COG0556	nucleotide-excision repair
GAY96_08605	COG0436	Aminotransferase
GAY96_08610	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GAY96_08620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GAY96_08625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GAY96_08640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GAY96_08645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GAY96_08650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GAY96_08655	COG1605	Chorismate mutase
GAY96_08655	COG0077	Prephenate dehydratase
GAY96_08660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GAY96_08700	COG2992	FlgJ-related protein
GAY96_08710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GAY96_08720	COG0204	Acyl-transferase
GAY96_08725	COG5001	Diguanylate cyclase
GAY96_08725	COG3706	GGDEF domain
GAY96_08725	COG2203	Gaf domain
GAY96_08725	COG4251	negative regulation of phosphorylation
GAY96_08735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GAY96_08760	COG0745	RESPONSE REGULATOR receiver
GAY96_08770	COG1025	Belongs to the peptidase M16 family
GAY96_08775	COG0300	oxidoreductase activity
GAY96_08815	COG0583	DNA-binding transcription factor activity
GAY96_08830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GAY96_08835	COG1138	Cytochrome C-type biogenesis protein
GAY96_08840	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GAY96_08855	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GAY96_08860	COG4133	protoheme IX ABC transporter activity
GAY96_08870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GAY96_08880	COG1285	pathogenesis
GAY96_08885	COG0402	S-adenosylhomocysteine deaminase activity
GAY96_08900	COG1028	Short-chain dehydrogenase reductase Sdr
GAY96_08915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GAY96_08930	COG0009	L-threonylcarbamoyladenylate synthase
GAY96_08935	COG0613	PHP domain protein
GAY96_08940	COG2350	Protein conserved in bacteria
GAY96_08950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GAY96_08960	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GAY96_08960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GAY96_08985	COG0543	2 iron, 2 sulfur cluster binding
GAY96_08985	COG0633	Ferredoxin
GAY96_08995	COG2081	HI0933 family
GAY96_09010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GAY96_09015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GAY96_09050	COG0575	Belongs to the CDS family
GAY96_09055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GAY96_09060	COG0233	cytoplasmic translational termination
GAY96_09065	COG0528	UMP kinase activity
GAY96_09070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GAY96_09075	COG0052	Belongs to the universal ribosomal protein uS2 family
GAY96_09080	COG0024	Methionine aminopeptidase
GAY96_09085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GAY96_09090	COG1741	Belongs to the pirin family
GAY96_09095	COG0513	Belongs to the DEAD box helicase family
GAY96_09115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GAY96_09120	COG0602	queuosine metabolic process
GAY96_09125	COG1028	Short-chain dehydrogenase reductase Sdr
GAY96_09125	COG3321	synthase
GAY96_09125	COG0604	alcohol dehydrogenase
GAY96_09135	COG3085	chromosome segregation
GAY96_09140	COG0189	ligase activity
GAY96_09140	COG4067	protein conserved in archaea
GAY96_09145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GAY96_09160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GAY96_09165	COG0583	DNA-binding transcription factor activity
GAY96_09170	COG2205	protein histidine kinase activity
GAY96_09175	COG0745	RESPONSE REGULATOR receiver
GAY96_09180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GAY96_09190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GAY96_09200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GAY96_09230	COG0835	chemotaxis
GAY96_09240	COG1192	Involved in chromosome partitioning
GAY96_09250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GAY96_09260	COG2198	Histidine kinase
GAY96_09260	COG0784	Response regulator, receiver
GAY96_09260	COG0643	Histidine kinase
GAY96_09290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GAY96_09305	COG1987	bacterial-type flagellum assembly
GAY96_09370	COG1677	Flagellar hook-basal body complex protein FliE
GAY96_09400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GAY96_09405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GAY96_09475	COG1706	bacterial-type flagellum-dependent cell motility
GAY96_09480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GAY96_09485	COG4786	Flagellar basal body rod
GAY96_09490	COG4787	bacterial-type flagellum-dependent cell motility
GAY96_09500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GAY96_09510	COG1815	bacterial-type flagellum-dependent cell motility
GAY96_09520	COG0784	Response regulator, receiver
GAY96_09520	COG0835	chemotaxis
GAY96_09540	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GAY96_09565	COG0393	Putative heavy-metal-binding
GAY96_09575	COG4783	chaperone-mediated protein folding
GAY96_09580	COG0492	ferredoxin-NADP+ reductase activity
GAY96_09605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GAY96_09620	COG0564	pseudouridine synthase activity
GAY96_09625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GAY96_09630	COG0335	large ribosomal subunit rRNA binding
GAY96_09635	COG0336	Belongs to the RNA methyltransferase TrmD family
GAY96_09640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GAY96_09645	COG0228	four-way junction DNA binding
GAY96_09650	COG1283	sodium-dependent phosphate transmembrane transporter activity
GAY96_09660	COG0047	phosphoribosylformylglycinamidine synthase activity
GAY96_09660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GAY96_09665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GAY96_09680	COG0023	Translation Initiation Factor
GAY96_09685	COG4191	Histidine kinase
GAY96_09685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GAY96_09690	COG1522	sequence-specific DNA binding
GAY96_09695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GAY96_09700	COG0210	DNA helicase
GAY96_09710	COG0625	glutathione transferase activity
GAY96_09715	COG0513	Belongs to the DEAD box helicase family
GAY96_09720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GAY96_09720	COG4191	Histidine kinase
GAY96_09725	COG3123	guanosine phosphorylase activity
GAY96_09735	COG3530	Putative quorum-sensing-regulated virulence factor
GAY96_09740	COG0519	Catalyzes the synthesis of GMP from XMP
GAY96_09740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GAY96_09765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GAY96_09775	COG0742	ribosomal rna small subunit methyltransferase
GAY96_09780	COG1968	undecaprenyl-diphosphatase activity
GAY96_09785	COG1214	PFAM Peptidase M22, glycoprotease
GAY96_09795	COG0563	adenylate kinase activity
GAY96_09800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GAY96_09805	COG3956	TIGRFAM MazG family protein
GAY96_09810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GAY96_09815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GAY96_09825	COG5002	protein histidine kinase activity
GAY96_09825	COG2205	protein histidine kinase activity
GAY96_09825	COG0784	Response regulator, receiver
GAY96_09830	COG0736	holo-[acyl-carrier-protein] synthase activity
GAY96_09840	COG1381	Involved in DNA repair and RecF pathway recombination
GAY96_09845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GAY96_09850	COG0571	ribonuclease III activity
GAY96_09860	COG0481	GTPase activity
GAY96_09865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GAY96_09915	COG1024	Enoyl-CoA hydratase
GAY96_09925	COG0596	Alpha beta hydrolase
GAY96_09935	COG0488	(ABC) transporter
GAY96_09965	COG0189	ligase activity
GAY96_09980	COG0084	hydrolase, TatD family'
GAY96_09990	COG0513	Belongs to the DEAD box helicase family
GAY96_09995	COG1028	Short-chain dehydrogenase reductase Sdr
GAY96_10000	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GAY96_10020	COG4628	conserved protein (DUF2132)
GAY96_10060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GAY96_10075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GAY96_10075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GAY96_10085	COG1132	(ABC) transporter
GAY96_10090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GAY96_10100	COG0705	Rhomboid family
GAY96_10105	COG1024	Enoyl-CoA hydratase
GAY96_10110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GAY96_10115	COG2814	Major facilitator Superfamily
GAY96_10120	COG1309	transcriptional regulator
GAY96_10135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GAY96_10140	COG1702	phosphate starvation-inducible protein PhoH
GAY96_10150	COG4535	Mg2 and Co2 transporter CorC
GAY96_10155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GAY96_10165	COG0494	nUDIX hydrolase
GAY96_10170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GAY96_10175	COG0653	protein targeting
GAY96_10180	COG0739	heme binding
GAY96_10200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GAY96_10205	COG1181	Belongs to the D-alanine--D-alanine ligase family
GAY96_10210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GAY96_10215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GAY96_10220	COG0772	Belongs to the SEDS family
GAY96_10225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GAY96_10230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GAY96_10235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GAY96_10250	COG3116	cell division
GAY96_10255	COG0275	rRNA processing
GAY96_10280	COG0450	alkyl hydroperoxide reductase
GAY96_10300	COG1309	transcriptional regulator
GAY96_10305	COG0509	glycine decarboxylation via glycine cleavage system
GAY96_10320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GAY96_10325	COG0579	oxidoreductase
GAY96_10330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GAY96_10340	COG3630	sodium ion export across plasma membrane
GAY96_10355	COG0625	glutathione transferase activity
GAY96_10360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GAY96_10365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GAY96_10370	COG2226	methyltransferase
GAY96_10375	COG1322	Protein conserved in bacteria
GAY96_10395	COG1115	amino acid carrier protein
GAY96_10405	COG3550	peptidyl-serine autophosphorylation
GAY96_10440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GAY96_10445	COG0237	dephospho-CoA kinase activity
GAY96_10450	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GAY96_10475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GAY96_10480	COG2264	protein methyltransferase activity
GAY96_10490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GAY96_10500	COG0138	bifunctional purine biosynthesis protein purh
GAY96_10505	COG0151	Belongs to the GarS family
GAY96_10510	COG5002	protein histidine kinase activity
GAY96_10510	COG0784	Response regulator, receiver
GAY96_10515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GAY96_10520	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GAY96_10525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GAY96_10530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GAY96_10535	COG3178	'Phosphotransferase
GAY96_10540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GAY96_10545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GAY96_10550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GAY96_10555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GAY96_10560	COG2967	ApaG domain
GAY96_10565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GAY96_10570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GAY96_10595	COG0617	tRNA 3'-terminal CCA addition
GAY96_10600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GAY96_10600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GAY96_10605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GAY96_10610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GAY96_10615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GAY96_10620	COG1610	YqeY-like protein
GAY96_10625	COG0358	DNA primase activity
GAY96_10650	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GAY96_10670	COG0697	spore germination
GAY96_10675	COG1280	lysine exporter protein (LysE YggA)
GAY96_10705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GAY96_10730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GAY96_10735	COG0527	aspartate kinase activity
GAY96_10740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GAY96_10760	COG0596	Alpha beta hydrolase
GAY96_10765	COG1252	NADH dehydrogenase
GAY96_10775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GAY96_10780	COG1546	Belongs to the CinA family
GAY96_10785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GAY96_10790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GAY96_10810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GAY96_10815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GAY96_10820	COG0585	pseudouridine synthase activity
GAY96_10825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GAY96_10830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GAY96_10845	COG0504	CTP synthase activity
GAY96_10855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GAY96_10865	COG0840	transmembrane signaling receptor activity
GAY96_10875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GAY96_10880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GAY96_10890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GAY96_10895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GAY96_10900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GAY96_10905	COG5007	Belongs to the BolA IbaG family
GAY96_10915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GAY96_10920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GAY96_10925	COG1127	ABC transporter
GAY96_10945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GAY96_10950	COG1137	ATPase activity
GAY96_10970	COG1660	Displays ATPase and GTPase activities
GAY96_10980	COG2239	Acts as a magnesium transporter
GAY96_10985	COG3028	Belongs to the UPF0307 family
GAY96_10990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GAY96_11000	COG1530	ribonuclease E activity
GAY96_11005	COG0424	maF-like protein
GAY96_11015	COG1792	Involved in formation and maintenance of cell shape
GAY96_11020	COG1077	Cell shape determining protein MreB Mrl
GAY96_11025	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GAY96_11030	COG0154	amidase activity
GAY96_11035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GAY96_11045	COG2969	positive regulation of protein catabolic process
GAY96_11050	COG0625	glutathione transferase activity
GAY96_11055	COG2857	Cytochrome c1
GAY96_11060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GAY96_11065	COG0723	plastoquinol--plastocyanin reductase activity
GAY96_11070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GAY96_11085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GAY96_11095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GAY96_11105	COG0456	acetyltransferase
GAY96_11115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GAY96_11125	COG1477	protein flavinylation
GAY96_11135	COG0018	arginyl-trna synthetase
GAY96_11140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GAY96_11155	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GAY96_11160	COG1687	branched-chain amino acid
GAY96_11170	COG0129	dihydroxy-acid dehydratase activity
GAY96_11175	COG1119	ATPase activity
GAY96_11180	COG0537	adenosine 5'-monophosphoramidase activity
GAY96_11200	COG1183	phosphatidylcholine synthase activity
GAY96_11210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GAY96_11215	COG2200	EAL domain
GAY96_11225	COG2166	iron-sulfur cluster assembly
GAY96_11230	COG0840	transmembrane signaling receptor activity
GAY96_11235	COG1136	(ABC) transporter
GAY96_11235	COG0577	efflux transmembrane transporter activity
GAY96_11240	COG0577	efflux transmembrane transporter activity
GAY96_11240	COG1136	(ABC) transporter
GAY96_11260	COG0126	phosphoglycerate kinase activity
GAY96_11265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GAY96_11270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GAY96_11280	COG0252	asparaginase activity
GAY96_11285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GAY96_11300	COG0564	pseudouridine synthase activity
GAY96_11345	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GAY96_11350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GAY96_11360	COG0583	DNA-binding transcription factor activity
GAY96_11370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GAY96_11375	COG0730	response to heat
GAY96_11395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GAY96_11400	COG0826	peptidase U32
GAY96_11415	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GAY96_11420	COG2315	Protein conserved in bacteria
GAY96_11445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GAY96_11455	COG0305	Participates in initiation and elongation during chromosome replication
GAY96_11460	COG0359	binds to the 23S rRNA
GAY96_11470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GAY96_11475	COG0360	Binds together with S18 to 16S ribosomal RNA
GAY96_11490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GAY96_11495	COG0288	reversible hydration of carbon dioxide
GAY96_11505	COG0439	Biotin carboxylase
GAY96_11515	COG3634	alkyl hydroperoxide reductase activity
GAY96_11520	COG0450	alkyl hydroperoxide reductase
GAY96_11530	COG0557	exoribonuclease II activity
GAY96_11540	COG0840	transmembrane signaling receptor activity
GAY96_11545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GAY96_11550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GAY96_11555	COG1047	Peptidyl-prolyl cis-trans
GAY96_11575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GAY96_11585	COG0254	rRNA binding
GAY96_11590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GAY96_11595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GAY96_11600	COG1309	transcriptional regulator
GAY96_11610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GAY96_11620	COG0493	'glutamate synthase
GAY96_11625	COG0067	glutamate synthase
GAY96_11625	COG0069	glutamate synthase activity
GAY96_11625	COG0070	glutamate synthase
GAY96_11635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GAY96_11640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GAY96_11680	COG0277	FAD linked oxidase domain protein
GAY96_11685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GAY96_11690	COG0107	imidazoleglycerol-phosphate synthase activity
GAY96_11695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GAY96_11705	COG0131	Imidazoleglycerol-phosphate dehydratase
GAY96_11725	COG1194	a g-specific adenine glycosylase
GAY96_11730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GAY96_11770	COG0739	heme binding
GAY96_11780	COG0316	Belongs to the HesB IscA family
GAY96_11795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GAY96_11805	COG1981	membrane
GAY96_11810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GAY96_11830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GAY96_11835	COG1757	Na H antiporter
GAY96_11855	COG0121	glutamine amidotransferase
GAY96_11875	COG1785	Belongs to the alkaline phosphatase family
GAY96_11880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GAY96_11890	COG3093	addiction module antidote protein HigA
GAY96_11895	COG1305	Transglutaminase-like
GAY96_11905	COG0714	Associated with various cellular activities
GAY96_11910	COG0640	Transcriptional regulator
GAY96_11915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GAY96_11925	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GAY96_11930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GAY96_11945	COG3307	-O-antigen
GAY96_11960	COG2201	protein-glutamate methylesterase activity
GAY96_11965	COG0784	Response regulator, receiver
GAY96_11965	COG2198	Histidine kinase
GAY96_11965	COG0643	Histidine kinase
GAY96_11970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GAY96_11975	COG0840	transmembrane signaling receptor activity
GAY96_11995	COG0189	ligase activity
GAY96_12005	COG1678	Uncharacterized ACR, COG1678
GAY96_12010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GAY96_12015	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GAY96_12020	COG0540	Belongs to the ATCase OTCase family
GAY96_12030	COG1519	Transferase
GAY96_12035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GAY96_12035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GAY96_12040	COG1560	Kdo2-lipid A biosynthetic process
GAY96_12050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GAY96_12065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GAY96_12065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GAY96_12085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GAY96_12090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GAY96_12100	COG0730	response to heat
GAY96_12110	COG2989	Protein conserved in bacteria
GAY96_12115	COG3108	Peptidase M15
GAY96_12120	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GAY96_12125	COG0494	nUDIX hydrolase
GAY96_12150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GAY96_12155	COG0210	DNA helicase
GAY96_12175	COG0004	ammonium transporteR
GAY96_12180	COG0347	Belongs to the P(II) protein family
GAY96_12210	COG1960	acyl-CoA dehydrogenase activity
GAY96_12215	COG1028	Short-chain dehydrogenase reductase Sdr
GAY96_12230	COG1028	Short-chain dehydrogenase reductase Sdr
GAY96_12235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GAY96_12240	COG1538	Outer membrane efflux protein
GAY96_12245	COG0494	nUDIX hydrolase
GAY96_12255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GAY96_12260	COG3150	esterase
GAY96_12275	COG1741	Belongs to the pirin family
GAY96_12315	COG1011	Hydrolase
GAY96_12335	COG0513	Belongs to the DEAD box helicase family
GAY96_12350	COG1704	LemA family
GAY96_12355	COG0501	Belongs to the peptidase M48B family
GAY96_12365	COG2177	Part of the ABC transporter FtsEX involved in
GAY96_12370	COG2884	Cell division ATP-binding protein ftsE
GAY96_12375	COG0552	protein localization to endoplasmic reticulum
GAY96_12385	COG0742	ribosomal rna small subunit methyltransferase
GAY96_12410	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GAY96_12415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GAY96_12420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GAY96_12425	COG0405	Gamma-glutamyltransferase
GAY96_12430	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GAY96_12445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GAY96_12450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GAY96_12455	COG2003	Belongs to the UPF0758 family
GAY96_12465	COG0756	dUTP diphosphatase activity
GAY96_12475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GAY96_12480	COG1309	transcriptional regulator
GAY96_12490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GAY96_12500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GAY96_12505	COG1561	YicC-like family, N-terminal region
GAY96_12515	COG1758	RNA polymerase activity
GAY96_12520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GAY96_12535	COG0583	DNA-binding transcription factor activity
GAY96_12540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GAY96_12555	COG0501	Belongs to the peptidase M48B family
GAY96_12560	COG4774	siderophore transport
GAY96_12580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GAY96_12600	COG1960	acyl-CoA dehydrogenase activity
GAY96_12605	COG3273	potassium ion transport
GAY96_12605	COG0471	metal ion transport
GAY96_12615	COG0494	nUDIX hydrolase
GAY96_12620	COG1011	Hydrolase
GAY96_12625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GAY96_12630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GAY96_12640	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GAY96_12725	COG2183	response to ionizing radiation
GAY96_12735	COG2918	glutathione biosynthetic process
GAY96_12745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GAY96_12780	COG0488	(ABC) transporter
GAY96_12790	COG1253	flavin adenine dinucleotide binding
GAY96_12795	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GAY96_12800	COG4988	ABC transporter
GAY96_12840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GAY96_12845	COG2363	Small membrane protein
GAY96_12850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GAY96_12860	COG0668	transmembrane transport
GAY96_12880	COG2959	enzyme of heme biosynthesis
GAY96_12890	COG0181	hydroxymethylbilane synthase activity
GAY96_12905	COG3275	phosphorelay sensor kinase activity
GAY96_12945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GAY96_12950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GAY96_12955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GAY96_12960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GAY96_12970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GAY96_12980	COG0356	it plays a direct role in the translocation of protons across the membrane
GAY96_12990	COG1475	DNA binding
GAY96_12995	COG1192	Involved in chromosome partitioning
GAY96_13005	COG0477	Major facilitator Superfamily
GAY96_13065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GAY96_13075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GAY96_13090	COG0582	viral genome integration into host DNA
GAY96_13110	COG1401	restriction endodeoxyribonuclease activity
GAY96_13125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GAY96_13130	COG1111	helicase
GAY96_13130	COG1205	dead DEAH box helicase
GAY96_13140	COG0445	tRNA wobble uridine modification
GAY96_13165	COG3038	cytochrome b561
GAY96_13180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GAY96_13185	COG0706	membrane insertase activity
GAY96_13190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GAY96_13195	COG0594	ribonuclease P activity
GAY96_13200	COG0230	Belongs to the bacterial ribosomal protein bL34 family