locus-tag	class	description
EGM51_00010	COG0438	transferase activity, transferring glycosyl groups
EGM51_00020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EGM51_00045	COG3547	Transposase (IS116 IS110 IS902 family)
EGM51_00080	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_00090	COG3119	arylsulfatase activity
EGM51_00095	COG2814	Major facilitator Superfamily
EGM51_00110	COG1012	belongs to the aldehyde dehydrogenase family
EGM51_00195	COG4585	Histidine kinase
EGM51_00220	COG4585	Histidine kinase
EGM51_00225	COG4585	Histidine kinase
EGM51_00230	COG2197	response regulator
EGM51_00245	COG3119	arylsulfatase activity
EGM51_00270	COG3250	beta-galactosidase activity
EGM51_00280	COG1012	belongs to the aldehyde dehydrogenase family
EGM51_00285	COG4948	Mandelate Racemase Muconate Lactonizing
EGM51_00290	COG1063	alcohol dehydrogenase
EGM51_00295	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_00300	COG1609	Transcriptional regulator
EGM51_00300	COG2207	Transcriptional regulator
EGM51_00320	COG3250	beta-galactosidase activity
EGM51_00330	COG2814	Major facilitator Superfamily
EGM51_00370	COG3119	arylsulfatase activity
EGM51_00375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGM51_00380	COG0826	peptidase U32
EGM51_00450	COG1442	glycosyl transferase family 8
EGM51_00450	COG1216	Glycosyl transferase, family 2
EGM51_00470	COG0438	transferase activity, transferring glycosyl groups
EGM51_00485	COG0438	transferase activity, transferring glycosyl groups
EGM51_00495	COG0438	transferase activity, transferring glycosyl groups
EGM51_00500	COG0438	transferase activity, transferring glycosyl groups
EGM51_00520	COG0110	maltose O-acetyltransferase activity
EGM51_00525	COG0463	Glycosyl transferase, family 2
EGM51_00570	COG0579	oxidoreductase
EGM51_00575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EGM51_00580	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EGM51_00585	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EGM51_00595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EGM51_00640	COG1151	hydroxylamine reductase activity
EGM51_00650	COG2501	S4 domain
EGM51_00715	COG0714	Associated with various cellular activities
EGM51_00720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGM51_00745	COG4372	Transposase
EGM51_00760	COG3119	arylsulfatase activity
EGM51_00795	COG2066	Belongs to the glutaminase family
EGM51_00850	COG1136	(ABC) transporter
EGM51_00930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGM51_00935	COG0358	DNA primase activity
EGM51_01040	COG1937	Protein conserved in bacteria
EGM51_01045	COG1230	cation diffusion facilitator family transporter
EGM51_01125	COG4412	M6 family metalloprotease domain protein
EGM51_01125	COG1404	Belongs to the peptidase S8 family
EGM51_01210	COG1937	Protein conserved in bacteria
EGM51_01215	COG5002	protein histidine kinase activity
EGM51_01220	COG2204	response regulator
EGM51_01225	COG2204	response regulator
EGM51_01255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGM51_01305	COG3411	Ferredoxin
EGM51_01310	COG4585	Histidine kinase
EGM51_01325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_01425	COG3584	3D domain protein
EGM51_01440	COG0657	acetylesterase activity
EGM51_01440	COG2755	lipolytic protein G-D-S-L family
EGM51_01535	COG1234	tRNA 3'-trailer cleavage
EGM51_01545	COG0706	membrane insertase activity
EGM51_01550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGM51_01555	COG0594	ribonuclease P activity
EGM51_01560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EGM51_01565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGM51_01590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EGM51_01595	COG1324	tolerance protein
EGM51_01625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGM51_01635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM51_01645	COG1131	(ABC) transporter
EGM51_01670	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EGM51_01705	COG3119	arylsulfatase activity
EGM51_01715	COG3119	arylsulfatase activity
EGM51_01720	COG3119	arylsulfatase activity
EGM51_01735	COG3250	beta-galactosidase activity
EGM51_01740	COG0142	geranyltranstransferase activity
EGM51_01775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM51_01780	COG1121	(ABC) transporter
EGM51_01785	COG3443	Belongs to the bacterial solute-binding protein 9 family
EGM51_01785	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGM51_01790	COG1872	DUF167
EGM51_01825	COG1518	maintenance of DNA repeat elements
EGM51_01830	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EGM51_01835	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGM51_01840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGM51_01845	COG0849	cell division
EGM51_01860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_01890	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGM51_01895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGM51_01910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM51_01915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGM51_01920	COG1450	Type ii and iii secretion system protein
EGM51_01940	COG4191	Histidine kinase
EGM51_01955	COG0673	inositol 2-dehydrogenase activity
EGM51_01960	COG1482	cell wall glycoprotein biosynthetic process
EGM51_01965	COG3250	beta-galactosidase activity
EGM51_01970	COG1968	undecaprenyl-diphosphatase activity
EGM51_01975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGM51_01975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGM51_01980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGM51_01985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM51_02000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGM51_02000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGM51_02005	COG0307	riboflavin synthase, alpha
EGM51_02015	COG2861	carbohydrate metabolic process
EGM51_02020	COG0300	oxidoreductase activity
EGM51_02035	COG0432	Pfam Uncharacterised protein family UPF0047
EGM51_02040	COG4536	flavin adenine dinucleotide binding
EGM51_02060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EGM51_02070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EGM51_02070	COG0674	pyruvate-flavodoxin oxidoreductase activity
EGM51_02090	COG0275	rRNA processing
EGM51_02100	COG0768	penicillin binding
EGM51_02110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGM51_02115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGM51_02120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGM51_02125	COG1388	LysM domain
EGM51_02130	COG0772	Belongs to the SEDS family
EGM51_02140	COG0564	pseudouridine synthase activity
EGM51_02145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGM51_02150	COG0778	Nitroreductase
EGM51_02155	COG3118	belongs to the thioredoxin family
EGM51_02195	COG0343	queuine tRNA-ribosyltransferase activity
EGM51_02205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGM51_02205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGM51_02225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGM51_02230	COG1366	Belongs to the anti-sigma-factor antagonist family
EGM51_02240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGM51_02240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EGM51_02245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_02255	COG5002	protein histidine kinase activity
EGM51_02270	COG0750	zinc metalloprotease
EGM51_02275	COG4589	Belongs to the CDS family
EGM51_02285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGM51_02295	COG0196	riboflavin kinase activity
EGM51_02300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGM51_02305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGM51_02330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EGM51_02340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGM51_02380	COG0509	glycine decarboxylation via glycine cleavage system
EGM51_02385	COG0321	lipoyl(octanoyl) transferase activity
EGM51_02390	COG0321	lipoyl(octanoyl) transferase activity
EGM51_02400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EGM51_02405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGM51_02410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGM51_02420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGM51_02425	COG0641	radical SAM
EGM51_02430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGM51_02435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGM51_02440	COG0805	protein transport
EGM51_02470	COG0527	aspartate kinase activity
EGM51_02475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EGM51_02480	COG0300	oxidoreductase activity
EGM51_02490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM51_02520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGM51_02525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGM51_02535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGM51_02540	COG0540	Belongs to the ATCase OTCase family
EGM51_02545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGM51_02550	COG0859	PFAM glycosyl transferase family 9
EGM51_02575	COG0720	synthase
EGM51_02580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGM51_02595	COG3119	arylsulfatase activity
EGM51_02605	COG2096	Adenosyltransferase
EGM51_02615	COG3239	Fatty acid desaturase
EGM51_02620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGM51_02630	COG1837	Belongs to the UPF0109 family
EGM51_02640	COG0335	large ribosomal subunit rRNA binding
EGM51_02645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGM51_02650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EGM51_02660	COG1702	phosphate starvation-inducible protein PhoH
EGM51_02670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EGM51_02670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGM51_02670	COG0674	pyruvate-flavodoxin oxidoreductase activity
EGM51_02670	COG1013	pyruvate-flavodoxin oxidoreductase activity
EGM51_02695	COG2207	Transcriptional regulator
EGM51_02695	COG1609	Transcriptional regulator
EGM51_02705	COG0800	Aldolase
EGM51_02710	COG3132	Protein of unknown function, DUF480
EGM51_02715	COG3119	arylsulfatase activity
EGM51_02725	COG2239	Acts as a magnesium transporter
EGM51_02730	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EGM51_02750	COG1605	Chorismate mutase
EGM51_02750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EGM51_02775	COG0351	phosphomethylpyrimidine kinase
EGM51_02780	COG2816	NAD+ diphosphatase activity
EGM51_02840	COG4968	Prepilin-type N-terminal cleavage methylation domain
EGM51_02845	COG0151	Belongs to the GarS family
EGM51_02855	COG3858	chitin binding
EGM51_02910	COG4191	Histidine kinase
EGM51_02980	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM51_02990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGM51_02995	COG1242	4 iron, 4 sulfur cluster binding
EGM51_03000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EGM51_03005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EGM51_03040	COG5012	cobalamin binding
EGM51_03045	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EGM51_03050	COG2116	formate transmembrane transporter activity
EGM51_03060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGM51_03065	COG2207	Transcriptional regulator
EGM51_03065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGM51_03075	COG0859	PFAM glycosyl transferase family 9
EGM51_03085	COG0668	transmembrane transport
EGM51_03095	COG2226	methyltransferase
EGM51_03100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_03105	COG4628	conserved protein (DUF2132)
EGM51_03120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGM51_03130	COG4977	sequence-specific DNA binding
EGM51_03155	COG1757	Na H antiporter
EGM51_03200	COG3119	arylsulfatase activity
EGM51_03225	COG5434	Belongs to the glycosyl hydrolase 28 family
EGM51_03235	COG3119	arylsulfatase activity
EGM51_03245	COG2207	Transcriptional regulator
EGM51_03245	COG1609	Transcriptional regulator
EGM51_03250	COG0246	Mannitol dehydrogenase
EGM51_03260	COG3250	beta-galactosidase activity
EGM51_03275	COG3119	arylsulfatase activity
EGM51_03290	COG3119	arylsulfatase activity
EGM51_03295	COG3119	arylsulfatase activity
EGM51_03330	COG1196	nuclear chromosome segregation
EGM51_03335	COG1196	nuclear chromosome segregation
EGM51_03345	COG3852	Histidine kinase
EGM51_03350	COG0471	metal ion transport
EGM51_03360	COG0776	regulation of translation
EGM51_03365	COG0124	histidyl-tRNA synthetase
EGM51_03370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGM51_03410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_03415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGM51_03435	COG0546	phosphoglycolate phosphatase activity
EGM51_03450	COG0237	dephospho-CoA kinase activity
EGM51_03475	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_03480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EGM51_03485	COG0825	malonyl-CoA metabolic process
EGM51_03490	COG0791	NLP P60 protein
EGM51_03490	COG1388	LysM domain
EGM51_03505	COG0497	DNA recombination
EGM51_03515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGM51_03525	COG0513	Belongs to the DEAD box helicase family
EGM51_03540	COG0416	fatty acid biosynthetic process
EGM51_03550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EGM51_03555	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_03560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGM51_03565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGM51_03570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGM51_03570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGM51_03600	COG0848	biopolymer transport protein
EGM51_03605	COG0848	biopolymer transport protein
EGM51_03635	COG1560	Kdo2-lipid A biosynthetic process
EGM51_03645	COG4657	Part of a membrane complex involved in electron transport
EGM51_03655	COG4656	Part of a membrane complex involved in electron transport
EGM51_03660	COG4658	electron transport chain
EGM51_03670	COG4659	FMN binding
EGM51_03675	COG4660	Part of a membrane complex involved in electron transport
EGM51_03755	COG1747	RNA polymerase binding
EGM51_03755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_03760	COG0515	serine threonine protein kinase
EGM51_03760	COG0457	Tetratricopeptide repeat
EGM51_03765	COG0408	coproporphyrinogen oxidase activity
EGM51_03770	COG0668	transmembrane transport
EGM51_03780	COG0166	Belongs to the GPI family
EGM51_03810	COG1959	2 iron, 2 sulfur cluster binding
EGM51_03815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGM51_03845	COG2273	Hydrolase Family 16
EGM51_03880	COG0436	Aminotransferase
EGM51_03885	COG1519	Transferase
EGM51_03895	COG0517	IMP dehydrogenase activity
EGM51_03895	COG1994	Peptidase M50
EGM51_03900	COG0640	Transcriptional regulator
EGM51_03905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EGM51_03910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGM51_03915	COG0530	calcium, potassium:sodium antiporter activity
EGM51_03935	COG1363	Peptidase, m42
EGM51_03955	COG0438	transferase activity, transferring glycosyl groups
EGM51_03980	COG1132	(ABC) transporter
EGM51_03995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EGM51_04000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EGM51_04005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EGM51_04095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGM51_04105	COG0442	prolyl-tRNA aminoacylation
EGM51_04135	COG3119	arylsulfatase activity
EGM51_04145	COG3119	arylsulfatase activity
EGM51_04160	COG3119	arylsulfatase activity
EGM51_04185	COG3250	beta-galactosidase activity
EGM51_04230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGM51_04235	COG0066	3-isopropylmalate dehydratase activity
EGM51_04240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGM51_04250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EGM51_04255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGM51_04260	COG0037	tRNA processing
EGM51_04265	COG0728	peptidoglycan biosynthetic process
EGM51_04305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGM51_04320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGM51_04340	COG5434	Belongs to the glycosyl hydrolase 28 family
EGM51_04350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGM51_04370	COG1104	cysteine desulfurase activity
EGM51_04375	COG0301	tRNA thio-modification
EGM51_04380	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGM51_04390	COG1105	Belongs to the carbohydrate kinase PfkB family
EGM51_04405	COG0318	PFAM AMP-dependent synthetase and ligase
EGM51_04420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EGM51_04425	COG0052	Belongs to the universal ribosomal protein uS2 family
EGM51_04430	COG1331	Highly conserved protein containing a thioredoxin domain
EGM51_04455	COG1459	type II secretion system
EGM51_04485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGM51_04545	COG4372	Transposase
EGM51_04570	COG3119	arylsulfatase activity
EGM51_04585	COG3119	arylsulfatase activity
EGM51_04590	COG4585	Histidine kinase
EGM51_04595	COG2197	response regulator
EGM51_04635	COG0673	inositol 2-dehydrogenase activity
EGM51_04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGM51_04680	COG3119	arylsulfatase activity
EGM51_04685	COG2169	Transcriptional regulator
EGM51_04710	COG1609	Transcriptional regulator
EGM51_04740	COG3850	Histidine kinase
EGM51_04745	COG2197	response regulator
EGM51_04760	COG3119	arylsulfatase activity
EGM51_04770	COG3119	arylsulfatase activity
EGM51_04775	COG3401	FG-GAP repeat protein
EGM51_04810	COG3119	arylsulfatase activity
EGM51_04820	COG3401	FG-GAP repeat protein
EGM51_04840	COG2211	Major facilitator Superfamily
EGM51_04855	COG0673	inositol 2-dehydrogenase activity
EGM51_04865	COG4585	Histidine kinase
EGM51_04870	COG2197	response regulator
EGM51_04875	COG0673	inositol 2-dehydrogenase activity
EGM51_04890	COG3401	FG-GAP repeat protein
EGM51_04910	COG3119	arylsulfatase activity
EGM51_04920	COG0445	tRNA wobble uridine modification
EGM51_04930	COG3119	arylsulfatase activity
EGM51_04945	COG3119	arylsulfatase activity
EGM51_04975	COG3250	beta-galactosidase activity
EGM51_05015	COG0395	ABC-type sugar transport system, permease component
EGM51_05025	COG1175	transmembrane transport
EGM51_05030	COG3842	ATPase activity
EGM51_05035	COG4977	sequence-specific DNA binding
EGM51_05035	COG1917	Cupin 2, conserved barrel domain protein
EGM51_05040	COG3119	arylsulfatase activity
EGM51_05045	COG1053	succinate dehydrogenase
EGM51_05060	COG1874	Beta-galactosidase
EGM51_05065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM51_05070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGM51_05075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EGM51_05080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGM51_05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM51_05105	COG1136	(ABC) transporter
EGM51_05120	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EGM51_05125	COG0542	response to heat
EGM51_05140	COG0018	arginyl-trna synthetase
EGM51_05170	COG0251	oxidation-reduction process
EGM51_05175	COG1477	protein flavinylation
EGM51_05185	COG0058	SHG alpha-glucan phosphorylase activity
EGM51_05190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGM51_05250	COG3119	arylsulfatase activity
EGM51_05265	COG0673	inositol 2-dehydrogenase activity
EGM51_05275	COG3119	arylsulfatase activity
EGM51_05295	COG2197	response regulator
EGM51_05300	COG3119	arylsulfatase activity
EGM51_05305	COG3119	arylsulfatase activity
EGM51_05340	COG2197	response regulator
EGM51_05345	COG4585	Histidine kinase
EGM51_05360	COG2197	response regulator
EGM51_05365	COG4585	Histidine kinase
EGM51_05430	COG3119	arylsulfatase activity
EGM51_05450	COG3119	arylsulfatase activity
EGM51_05455	COG0673	inositol 2-dehydrogenase activity
EGM51_05490	COG3119	arylsulfatase activity
EGM51_05555	COG1472	Belongs to the glycosyl hydrolase 3 family
EGM51_05560	COG4753	response regulator
EGM51_05560	COG2207	Transcriptional regulator
EGM51_05570	COG3250	beta-galactosidase activity
EGM51_05600	COG0494	nUDIX hydrolase
EGM51_05605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EGM51_05620	COG0482	sulfurtransferase activity
EGM51_05635	COG1187	pseudouridine synthase activity
EGM51_05650	COG1917	Cupin 2, conserved barrel domain protein
EGM51_05655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EGM51_05665	COG1846	Transcriptional regulator
EGM51_05680	COG1254	Belongs to the acylphosphatase family
EGM51_05690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EGM51_05700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EGM51_05710	COG0047	phosphoribosylformylglycinamidine synthase activity
EGM51_05715	COG0284	orotidine-5'-phosphate decarboxylase activity
EGM51_05720	COG0366	Alpha amylase catalytic
EGM51_05725	COG0438	transferase activity, transferring glycosyl groups
EGM51_05735	COG1215	transferase activity, transferring glycosyl groups
EGM51_05745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGM51_05745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGM51_05755	COG1216	Glycosyl transferase, family 2
EGM51_05760	COG2308	Evidence 4 Homologs of previously reported genes of
EGM51_05800	COG1368	sulfuric ester hydrolase activity
EGM51_05805	COG1643	Atp-dependent helicase
EGM51_05810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM51_05815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EGM51_05815	COG0517	IMP dehydrogenase activity
EGM51_05825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGM51_05840	COG0328	RNA-DNA hybrid ribonuclease activity
EGM51_05860	COG0514	ATP-dependent DNA helicase (RecQ)
EGM51_05875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGM51_05880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGM51_05885	COG0287	Prephenate dehydrogenase
EGM51_05890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGM51_05895	COG3119	arylsulfatase activity
EGM51_05905	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EGM51_05920	COG0423	glycine-tRNA ligase activity
EGM51_05935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGM51_05955	COG1127	ABC transporter
EGM51_05960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM51_05975	COG0489	protein tyrosine kinase activity
EGM51_05980	COG2151	metal-sulfur cluster biosynthetic enzyme
EGM51_05990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGM51_05995	COG0719	Fe-S assembly protein
EGM51_06000	COG0396	ATPase activity
EGM51_06005	COG0719	Fe-S assembly protein
EGM51_06015	COG3956	TIGRFAM MazG family protein
EGM51_06025	COG0505	Belongs to the CarA family
EGM51_06030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGM51_06030	COG0519	Catalyzes the synthesis of GMP from XMP
EGM51_06035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EGM51_06045	COG1663	tetraacyldisaccharide 4'-kinase activity
EGM51_06055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGM51_06065	COG1691	(AIR) carboxylase
EGM51_06070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGM51_06075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM51_06090	COG3119	arylsulfatase activity
EGM51_06095	COG3119	arylsulfatase activity
EGM51_06100	COG1917	Cupin 2, conserved barrel domain protein
EGM51_06100	COG2207	Transcriptional regulator
EGM51_06115	COG4948	Mandelate Racemase Muconate Lactonizing
EGM51_06120	COG1012	belongs to the aldehyde dehydrogenase family
EGM51_06125	COG0800	Aldolase
EGM51_06155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM51_06165	COG3250	beta-galactosidase activity
EGM51_06170	COG3119	arylsulfatase activity
EGM51_06175	COG3119	arylsulfatase activity
EGM51_06205	COG2169	Transcriptional regulator
EGM51_06205	COG1917	Cupin 2, conserved barrel domain protein
EGM51_06210	COG3250	beta-galactosidase activity
EGM51_06230	COG1312	Catalyzes the dehydration of D-mannonate
EGM51_06265	COG3401	FG-GAP repeat protein
EGM51_06270	COG3401	FG-GAP repeat protein
EGM51_06300	COG2211	Major facilitator Superfamily
EGM51_06305	COG3250	beta-galactosidase activity
EGM51_06315	COG1609	Transcriptional regulator
EGM51_06320	COG0708	Exodeoxyribonuclease III
EGM51_06325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EGM51_06330	COG1509	lysine 2,3-aminomutase activity
EGM51_06340	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGM51_06345	COG1805	sodium ion transport
EGM51_06350	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGM51_06360	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGM51_06375	COG0659	secondary active sulfate transmembrane transporter activity
EGM51_06380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EGM51_06385	COG2234	aminopeptidase activity
EGM51_06400	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EGM51_06405	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EGM51_06430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EGM51_06435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGM51_06440	COG3119	arylsulfatase activity
EGM51_06445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGM51_06450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM51_06465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM51_06505	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EGM51_06520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EGM51_06525	COG0205	6-phosphofructokinase activity
EGM51_06530	COG0737	Belongs to the 5'-nucleotidase family
EGM51_06535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EGM51_06560	COG0528	UMP kinase activity
EGM51_06565	COG0233	cytoplasmic translational termination
EGM51_06570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EGM51_06590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGM51_06600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EGM51_06615	COG0297	glycogen (starch) synthase activity
EGM51_06620	COG0557	exoribonuclease II activity
EGM51_06640	COG1192	Involved in chromosome partitioning
EGM51_06650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EGM51_06660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGM51_06675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EGM51_06685	COG1136	(ABC) transporter
EGM51_06685	COG0577	efflux transmembrane transporter activity
EGM51_06690	COG0577	efflux transmembrane transporter activity
EGM51_06690	COG1136	(ABC) transporter
EGM51_06710	COG0590	tRNA wobble adenosine to inosine editing
EGM51_06715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGM51_06725	COG1132	(ABC) transporter
EGM51_06730	COG1132	(ABC) transporter
EGM51_06735	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_06740	COG0277	FAD linked oxidase domain protein
EGM51_06750	COG1322	Protein conserved in bacteria
EGM51_06755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_06760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_06765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGM51_06775	COG1027	Aspartate ammonia-lyase
EGM51_06810	COG1368	sulfuric ester hydrolase activity
EGM51_06830	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EGM51_06835	COG1609	Transcriptional regulator
EGM51_06840	COG1609	Transcriptional regulator
EGM51_06855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EGM51_06885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EGM51_06890	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EGM51_06895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_06900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EGM51_06905	COG0116	Belongs to the methyltransferase superfamily
EGM51_06945	COG4372	Transposase
EGM51_06960	COG0516	GMP reductase activity
EGM51_06960	COG0517	IMP dehydrogenase activity
EGM51_06965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGM51_06965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGM51_06980	COG0512	Glutamine amidotransferase of anthranilate synthase
EGM51_07000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM51_07005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGM51_07015	COG0107	imidazoleglycerol-phosphate synthase activity
EGM51_07020	COG0557	exoribonuclease II activity
EGM51_07025	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EGM51_07030	COG2003	Belongs to the UPF0758 family
EGM51_07035	COG0756	dUTP diphosphatase activity
EGM51_07040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGM51_07045	COG0733	neurotransmitter:sodium symporter activity
EGM51_07055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGM51_07070	COG0745	RESPONSE REGULATOR receiver
EGM51_07075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EGM51_07075	COG0316	Belongs to the HesB IscA family
EGM51_07085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGM51_07090	COG2124	cytochrome p450
EGM51_07095	COG0525	valine-tRNA ligase activity
EGM51_07105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_07135	COG3425	synthase
EGM51_07145	COG0023	Translation Initiation Factor
EGM51_07150	COG2996	Protein conserved in bacteria
EGM51_07155	COG0513	Belongs to the DEAD box helicase family
EGM51_07180	COG2131	deaminase
EGM51_07190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGM51_07190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGM51_07200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EGM51_07215	COG0159	tryptophan synthase activity
EGM51_07220	COG0848	biopolymer transport protein
EGM51_07225	COG0848	biopolymer transport protein
EGM51_07230	COG0811	peptide transport
EGM51_07275	COG2703	oxygen carrier activity
EGM51_07285	COG2738	Putative neutral zinc metallopeptidase
EGM51_07315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGM51_07350	COG0848	biopolymer transport protein
EGM51_07355	COG0811	peptide transport
EGM51_07405	COG0745	RESPONSE REGULATOR receiver
EGM51_07410	COG5002	protein histidine kinase activity
EGM51_07415	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGM51_07435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EGM51_07445	COG0581	inorganic phosphate transmembrane transporter activity
EGM51_07450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGM51_07455	COG0704	Plays a role in the regulation of phosphate uptake
EGM51_07485	COG0322	excinuclease ABC activity
EGM51_07510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EGM51_07515	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EGM51_07520	COG3005	denitrification pathway
EGM51_07525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGM51_07530	COG2226	methyltransferase
EGM51_07535	COG0571	ribonuclease III activity
EGM51_07545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGM51_07555	COG0747	negative chemotaxis
EGM51_07565	COG0149	triose-phosphate isomerase activity
EGM51_07580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGM51_07580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGM51_07620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGM51_07625	COG0154	amidase activity
EGM51_07630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGM51_07655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGM51_07670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGM51_07680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EGM51_07685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGM51_07710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM51_07730	COG1528	Iron-storage protein
EGM51_07735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGM51_07755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGM51_07760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGM51_07790	COG1966	Carbon starvation protein
EGM51_07795	COG0302	gtp cyclohydrolase
EGM51_07810	COG3119	arylsulfatase activity
EGM51_07815	COG3083	sulfuric ester hydrolase activity
EGM51_07820	COG3119	arylsulfatase activity
EGM51_07830	COG3119	arylsulfatase activity
EGM51_07835	COG0667	Aldo Keto reductase
EGM51_07840	COG3250	beta-galactosidase activity
EGM51_07855	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
EGM51_07860	COG1063	alcohol dehydrogenase
EGM51_07865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGM51_07870	COG0406	alpha-ribazole phosphatase activity
EGM51_07880	COG0738	Major facilitator superfamily
EGM51_07885	COG0656	L-ascorbic acid biosynthetic process
EGM51_07905	COG0129	dihydroxy-acid dehydratase activity
EGM51_07910	COG0402	S-adenosylhomocysteine deaminase activity
EGM51_07915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGM51_07955	COG0438	transferase activity, transferring glycosyl groups
EGM51_07980	COG0438	transferase activity, transferring glycosyl groups
EGM51_07995	COG0859	PFAM glycosyl transferase family 9
EGM51_08015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM51_08030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGM51_08040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EGM51_08055	COG1088	dTDP-glucose 4,6-dehydratase activity
EGM51_08065	COG0529	Catalyzes the synthesis of activated sulfate
EGM51_08065	COG2895	sulfate adenylyltransferase (ATP) activity
EGM51_08075	COG0175	sulfate reduction
EGM51_08080	COG3273	potassium ion transport
EGM51_08080	COG0471	metal ion transport
EGM51_08090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EGM51_08105	COG4786	Flagellar basal body rod
EGM51_08105	COG1256	bacterial-type flagellum assembly
EGM51_08120	COG1706	bacterial-type flagellum-dependent cell motility
EGM51_08125	COG1706	bacterial-type flagellum-dependent cell motility
EGM51_08130	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EGM51_08145	COG4786	Flagellar basal body rod
EGM51_08150	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGM51_08150	COG1776	CheC inhibitor of MCP methylation
EGM51_08155	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGM51_08170	COG1360	Flagellar Motor Protein
EGM51_08175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EGM51_08185	COG4786	Flagellar basal body rod
EGM51_08190	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EGM51_08210	COG1157	protein secretion by the type III secretion system
EGM51_08220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGM51_08235	COG1558	bacterial-type flagellum-dependent cell motility
EGM51_08240	COG1815	bacterial-type flagellum-dependent cell motility
EGM51_08245	COG2204	response regulator
EGM51_08250	COG4566	intracellular signal transduction
EGM51_08260	COG0784	Response regulator, receiver
EGM51_08260	COG4191	Histidine kinase
EGM51_08265	COG1191	sigma factor activity
EGM51_08275	COG0455	bacterial-type flagellum organization
EGM51_08280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGM51_08285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGM51_08300	COG1338	Plays a role in the flagellum-specific transport system
EGM51_08320	COG2204	response regulator
EGM51_08325	COG5000	phosphorelay sensor kinase activity
EGM51_08330	COG2204	response regulator
EGM51_08345	COG2205	protein histidine kinase activity
EGM51_08345	COG2198	Histidine kinase
EGM51_08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGM51_08345	COG0784	Response regulator, receiver
EGM51_08355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_08360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EGM51_08365	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
EGM51_08370	COG0367	asparagine synthase
EGM51_08375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EGM51_08380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_08385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_08390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_08395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_08415	COG2205	protein histidine kinase activity
EGM51_08415	COG0784	Response regulator, receiver
EGM51_08425	COG0745	RESPONSE REGULATOR receiver
EGM51_08450	COG1011	Hydrolase
EGM51_08460	COG1187	pseudouridine synthase activity
EGM51_08485	COG0569	domain protein
EGM51_08495	COG0366	Alpha amylase catalytic
EGM51_08500	COG0297	glycogen (starch) synthase activity
EGM51_08505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EGM51_08520	COG0028	Belongs to the TPP enzyme family
EGM51_08535	COG1113	amino acid transport
EGM51_08540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGM51_08550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EGM51_08605	COG0450	alkyl hydroperoxide reductase
EGM51_08610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGM51_08620	COG1686	Belongs to the peptidase S11 family
EGM51_08630	COG0544	peptidyl-prolyl cis-trans isomerase activity
EGM51_08635	COG0740	serine-type endopeptidase activity
EGM51_08640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EGM51_08665	COG0588	phosphoglycerate mutase activity
EGM51_08675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGM51_08695	COG0546	phosphoglycolate phosphatase activity
EGM51_08720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGM51_08725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGM51_08740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGM51_08765	COG0673	inositol 2-dehydrogenase activity
EGM51_08770	COG0673	inositol 2-dehydrogenase activity
EGM51_08775	COG0673	inositol 2-dehydrogenase activity
EGM51_08805	COG4988	ABC transporter
EGM51_08810	COG0390	transport system, permease component
EGM51_08820	COG0473	3-isopropylmalate dehydrogenase activity
EGM51_08825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGM51_08845	COG2239	Acts as a magnesium transporter
EGM51_08850	COG1381	Involved in DNA repair and RecF pathway recombination
EGM51_08860	COG1215	transferase activity, transferring glycosyl groups
EGM51_08865	COG0463	Glycosyl transferase, family 2
EGM51_08870	COG1083	cytidylyl-transferase
EGM51_08915	COG1215	transferase activity, transferring glycosyl groups
EGM51_08940	COG0438	transferase activity, transferring glycosyl groups
EGM51_08945	COG1185	polyribonucleotide nucleotidyltransferase activity
EGM51_08950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGM51_08955	COG3119	arylsulfatase activity
EGM51_08965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGM51_08970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGM51_08975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EGM51_08980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EGM51_08985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGM51_09000	COG0126	phosphoglycerate kinase activity
EGM51_09025	COG1730	sister chromatid segregation
EGM51_09030	COG4659	FMN binding
EGM51_09050	COG0492	ferredoxin-NADP+ reductase activity
EGM51_09055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGM51_09070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGM51_09085	COG0504	CTP synthase activity
EGM51_09100	COG2135	peptidase activity
EGM51_09105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGM51_09115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGM51_09120	COG0215	cysteine-tRNA ligase activity
EGM51_09125	COG0799	negative regulation of ribosome biogenesis
EGM51_09130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGM51_09140	COG0489	protein tyrosine kinase activity
EGM51_09145	COG3944	biosynthesis protein
EGM51_09170	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGM51_09175	COG0848	biopolymer transport protein
EGM51_09180	COG0848	biopolymer transport protein
EGM51_09205	COG0254	rRNA binding
EGM51_09210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EGM51_09225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EGM51_09245	COG0811	peptide transport
EGM51_09265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGM51_09270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGM51_09310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGM51_09315	COG0330	HflC and HflK could
EGM51_09325	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_09335	COG2832	Protein of unknown function (DUF454)
EGM51_09340	COG0011	TIGRFAM Protein of
EGM51_09345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EGM51_09390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGM51_09395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGM51_09400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGM51_09405	COG0519	Catalyzes the synthesis of GMP from XMP
EGM51_09415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGM51_09475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_09480	COG0352	thiamine-phosphate diphosphorylase activity
EGM51_09485	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EGM51_09505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_09515	COG2130	NADP-dependent
EGM51_09520	COG1979	alcohol dehydrogenase
EGM51_09530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EGM51_09545	COG1309	transcriptional regulator
EGM51_09600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EGM51_09615	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EGM51_09620	COG2226	methyltransferase
EGM51_09625	COG0163	prenyltransferase activity
EGM51_09630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EGM51_09635	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EGM51_09640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGM51_09645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM51_09670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGM51_09680	COG0523	cobalamin synthesis protein
EGM51_09695	COG2814	Major facilitator Superfamily
EGM51_09710	COG1904	glucuronate isomerase
EGM51_09720	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EGM51_09725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM51_09730	COG1312	Catalyzes the dehydration of D-mannonate
EGM51_09735	COG0784	Response regulator, receiver
EGM51_09735	COG2205	protein histidine kinase activity
EGM51_09770	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EGM51_09890	COG2801	Transposase and inactivated derivatives
EGM51_09890	COG3415	Transposase
EGM51_09945	COG4372	Transposase
EGM51_09980	COG3547	Transposase (IS116 IS110 IS902 family)
EGM51_09995	COG4232	protein-disulfide reductase activity
EGM51_10000	COG0617	tRNA 3'-terminal CCA addition
EGM51_10015	COG1127	ABC transporter
EGM51_10020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM51_10040	COG1045	serine acetyltransferase
EGM51_10045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EGM51_10050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EGM51_10060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGM51_10065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EGM51_10070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGM51_10115	COG1047	Peptidyl-prolyl cis-trans
EGM51_10120	COG2081	HI0933 family
EGM51_10135	COG3228	Belongs to the MtfA family
EGM51_10145	COG0702	epimerase
EGM51_10160	COG1214	PFAM Peptidase M22, glycoprotease
EGM51_10165	COG0802	atpase or kinase
EGM51_10175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_10205	COG2890	protein-(glutamine-N5) methyltransferase activity
EGM51_10225	COG1929	Belongs to the glycerate kinase type-1 family
EGM51_10230	COG1609	Transcriptional regulator
EGM51_10240	COG1120	ATPase activity
EGM51_10245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGM51_10250	COG1492	cobalamin metabolic process
EGM51_10255	COG0519	Catalyzes the synthesis of GMP from XMP
EGM51_10265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EGM51_10280	COG1674	ftsk spoiiie
EGM51_10285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EGM51_10300	COG0203	ribosomal protein L17
EGM51_10305	COG0202	RNA polymerase activity
EGM51_10310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EGM51_10315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGM51_10325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGM51_10330	COG0024	Methionine aminopeptidase
EGM51_10340	COG0201	protein transport
EGM51_10350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGM51_10355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGM51_10360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGM51_10370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EGM51_10375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EGM51_10380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EGM51_10390	COG0255	Belongs to the universal ribosomal protein uL29 family
EGM51_10395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EGM51_10400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGM51_10405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EGM51_10410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGM51_10415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EGM51_10420	COG0089	rRNA binding
EGM51_10425	COG0088	Forms part of the polypeptide exit tunnel
EGM51_10430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGM51_10435	COG0051	transcription antitermination factor activity, RNA binding
EGM51_10440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGM51_10445	COG0049	tRNA binding
EGM51_10450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGM51_10455	COG1278	Cold shock
EGM51_10470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGM51_10470	COG2169	Transcriptional regulator
EGM51_10475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGM51_10480	COG0085	RNA polymerase activity
EGM51_10485	COG0222	ribosome binding
EGM51_10495	COG0081	regulation of translation
EGM51_10500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EGM51_10505	COG0250	Participates in transcription elongation, termination and antitermination
EGM51_10520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGM51_10525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGM51_10535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_10555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGM51_10740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGM51_10770	COG0646	methionine synthase
EGM51_10770	COG1410	methionine synthase
EGM51_10775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EGM51_10775	COG0646	methionine synthase
EGM51_10790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM51_10805	COG1074	ATP-dependent DNA helicase activity
EGM51_10810	COG1074	ATP-dependent DNA helicase activity
EGM51_10820	COG0463	Glycosyl transferase, family 2
EGM51_10830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGM51_10835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EGM51_10855	COG1131	(ABC) transporter
EGM51_10880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGM51_10890	COG0012	GTP binding
EGM51_10895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EGM51_10910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_10915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM51_10930	COG0352	thiamine-phosphate diphosphorylase activity
EGM51_10955	COG1119	ATPase activity
EGM51_10970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM51_10980	COG1611	Belongs to the LOG family
EGM51_10995	COG0501	Belongs to the peptidase M48B family
EGM51_11000	COG1475	DNA binding
EGM51_11020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EGM51_11035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGM51_11050	COG0439	Biotin carboxylase
EGM51_11055	COG0511	ligase activity, forming carbon-carbon bonds
EGM51_11065	COG0673	inositol 2-dehydrogenase activity
EGM51_11080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EGM51_11090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGM51_11110	COG0513	Belongs to the DEAD box helicase family
EGM51_11115	COG0138	bifunctional purine biosynthesis protein purh
EGM51_11120	COG1272	protein, Hemolysin III
EGM51_11125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGM51_11130	COG2848	UPF0210 protein
EGM51_11135	COG3830	Belongs to the UPF0237 family
EGM51_11165	COG1294	oxidase, subunit
EGM51_11170	COG1271	oxidase subunit
EGM51_11175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EGM51_11195	COG2217	Heavy metal translocating P-type atpase
EGM51_11245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EGM51_11260	COG0493	'glutamate synthase
EGM51_11265	COG1278	Cold shock
EGM51_11275	COG1051	belongs to the nudix hydrolase family
EGM51_11280	COG0668	transmembrane transport
EGM51_11285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EGM51_11285	COG0646	methionine synthase
EGM51_11290	COG0668	transmembrane transport
EGM51_11300	COG0708	Exodeoxyribonuclease III
EGM51_11305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGM51_11315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM51_11325	COG2233	PERMEase
EGM51_11330	COG2183	response to ionizing radiation
EGM51_11340	COG0038	chloride channel
EGM51_11355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGM51_11360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGM51_11365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGM51_11375	COG0137	argininosuccinate synthase activity
EGM51_11385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EGM51_11390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGM51_11395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EGM51_11400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGM51_11405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGM51_11415	COG0745	RESPONSE REGULATOR receiver
EGM51_11415	COG3706	GGDEF domain
EGM51_11440	COG0268	Binds directly to 16S ribosomal RNA
EGM51_11450	COG0481	GTPase activity
EGM51_11460	COG0543	2 iron, 2 sulfur cluster binding
EGM51_11465	COG0167	dihydroorotate dehydrogenase activity
EGM51_11515	COG0457	Tetratricopeptide repeat
EGM51_11515	COG0515	serine threonine protein kinase
EGM51_11525	COG0534	Mate efflux family protein
EGM51_11535	COG1785	Belongs to the alkaline phosphatase family
EGM51_11575	COG1566	PFAM secretion protein HlyD family protein
EGM51_11585	COG0534	Mate efflux family protein
EGM51_11595	COG0194	GDP metabolic process
EGM51_11600	COG1561	YicC-like family, N-terminal region
EGM51_11665	COG0133	tryptophan synthase activity
EGM51_11675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM51_11680	COG0135	phosphoribosylanthranilate isomerase activity
EGM51_11685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EGM51_11690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_11700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGM51_11705	COG3494	Protein of unknown function (DUF1009)
EGM51_11730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EGM51_11760	COG1609	Transcriptional regulator
EGM51_11825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM51_11850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGM51_11870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGM51_11880	COG0459	protein refolding
EGM51_11885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EGM51_11890	COG0443	Heat shock 70 kDa protein
EGM51_11900	COG2095	MarC family integral membrane protein
EGM51_11920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGM51_11925	COG1720	tRNA m6t6A37 methyltransferase activity
EGM51_11945	COG3661	Belongs to the glycosyl hydrolase 67 family
EGM51_11955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EGM51_11960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGM51_11980	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EGM51_11985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EGM51_12025	COG2197	response regulator
EGM51_12045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EGM51_12065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EGM51_12065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EGM51_12095	COG3415	Transposase
EGM51_12095	COG2801	Transposase and inactivated derivatives
EGM51_12115	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EGM51_12125	COG0347	Belongs to the P(II) protein family
EGM51_12160	COG1433	Dinitrogenase iron-molybdenum cofactor
EGM51_12160	COG0535	radical SAM domain protein
EGM51_12185	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGM51_12195	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGM51_12205	COG4149	molybdate abc transporter
EGM51_12210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EGM51_12220	COG3773	Cell wall hydrolase
EGM51_12235	COG1355	regulation of microtubule-based process
EGM51_12290	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EGM51_12305	COG4206	TonB-dependent receptor
EGM51_12325	COG1061	Type III restriction enzyme res subunit
EGM51_12375	COG2076	Multidrug Resistance protein
EGM51_12380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGM51_12395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_12430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EGM51_12440	COG0457	Tetratricopeptide repeat
EGM51_12455	COG1917	Cupin 2, conserved barrel domain protein
EGM51_12455	COG2207	Transcriptional regulator
EGM51_12460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM51_12465	COG2165	general secretion pathway protein
EGM51_12470	COG2165	general secretion pathway protein
EGM51_12480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGM51_12490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGM51_12500	COG0386	Belongs to the glutathione peroxidase family
EGM51_12510	COG1404	Belongs to the peptidase S8 family
EGM51_12525	COG0574	Belongs to the PEP-utilizing enzyme family
EGM51_12525	COG3848	Pyruvate phosphate dikinase
EGM51_12545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EGM51_12555	COG0436	Aminotransferase
EGM51_12560	COG1522	sequence-specific DNA binding
EGM51_12585	COG0285	dihydrofolate synthase activity
EGM51_12590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGM51_12595	COG1040	competence protein
EGM51_12605	COG0084	hydrolase, TatD family'
EGM51_12655	COG0606	chelatase, subunit chli
EGM51_12665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EGM51_12675	COG2363	Small membrane protein
EGM51_12685	COG3256	nitric oxide reductase
EGM51_12690	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EGM51_12695	COG3189	MarR family transcriptional regulator
EGM51_12700	COG1794	racemase activity, acting on amino acids and derivatives
EGM51_12705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGM51_12710	COG3263	regulation of cellular component size
EGM51_12720	COG4191	Histidine kinase
EGM51_12725	COG2204	response regulator
EGM51_12730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_12740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_12750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_12765	COG0259	pyridoxamine-phosphate oxidase activity
EGM51_12770	COG0348	domain, Protein
EGM51_12780	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EGM51_12805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGM51_12810	COG0798	PFAM Bile acid sodium symporter
EGM51_12865	COG3209	COG3209 Rhs family protein
EGM51_12895	COG0347	Belongs to the P(II) protein family
EGM51_12900	COG0004	ammonium transporteR
EGM51_12905	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EGM51_12910	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EGM51_12925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EGM51_12930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGM51_12940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGM51_12945	COG2267	carboxylic ester hydrolase activity
EGM51_12955	COG1136	(ABC) transporter
EGM51_12955	COG0577	efflux transmembrane transporter activity
EGM51_12960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_12980	COG4106	trans-aconitate 2-methyltransferase activity
EGM51_12985	COG0500	methyltransferase
EGM51_12990	COG0583	DNA-binding transcription factor activity
EGM51_13005	COG1733	regulation of RNA biosynthetic process
EGM51_13025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_13025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EGM51_13030	COG1396	sequence-specific DNA binding
EGM51_13055	COG3177	Filamentation induced by cAMP protein fic
EGM51_13085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EGM51_13105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM51_13115	COG0424	maF-like protein
EGM51_13130	COG0784	Response regulator, receiver
EGM51_13130	COG2205	protein histidine kinase activity
EGM51_13130	COG5002	protein histidine kinase activity
EGM51_13165	COG3720	iron ion transport
EGM51_13170	COG1959	2 iron, 2 sulfur cluster binding
EGM51_13175	COG4206	TonB-dependent receptor
EGM51_13190	COG2221	Nitrite and sulphite reductase 4Fe-4S
EGM51_13225	COG0811	peptide transport
EGM51_13230	COG0811	peptide transport
EGM51_13235	COG0848	biopolymer transport protein
EGM51_13275	COG0848	biopolymer transport protein
EGM51_13280	COG0811	peptide transport
EGM51_13285	COG0811	peptide transport
EGM51_13295	COG1120	ATPase activity
EGM51_13305	COG0667	Aldo Keto reductase
EGM51_13310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGM51_13350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGM51_13400	COG0543	2 iron, 2 sulfur cluster binding
EGM51_13405	COG0493	'glutamate synthase
EGM51_13410	COG0493	'glutamate synthase
EGM51_13415	COG0067	glutamate synthase
EGM51_13415	COG0070	glutamate synthase
EGM51_13415	COG0069	glutamate synthase activity
EGM51_13435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGM51_13450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGM51_13455	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EGM51_13465	COG0731	radical SAM domain protein
EGM51_13465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGM51_13470	COG2133	pyrroloquinoline quinone binding
EGM51_13475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGM51_13490	COG0358	DNA primase activity
EGM51_13520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EGM51_13545	COG4221	oxidoreductase activity
EGM51_13555	COG2208	phosphoserine phosphatase activity
EGM51_13555	COG2770	Histidine kinase
EGM51_13575	COG1132	(ABC) transporter
EGM51_13605	COG1414	Transcriptional regulator
EGM51_13610	COG1049	propionate catabolic process, 2-methylcitrate cycle
EGM51_13625	COG0242	peptide deformylase activity
EGM51_13650	COG1295	ribonuclease BN
EGM51_13660	COG0129	dihydroxy-acid dehydratase activity
EGM51_13670	COG0667	Aldo Keto reductase
EGM51_13675	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_13685	COG0156	8-amino-7-oxononanoate synthase activity
EGM51_13690	COG2267	carboxylic ester hydrolase activity
EGM51_13695	COG4067	protein conserved in archaea
EGM51_13695	COG0189	ligase activity
EGM51_13700	COG0189	ligase activity
EGM51_13720	COG0598	Magnesium transport protein CorA
EGM51_13745	COG4106	trans-aconitate 2-methyltransferase activity
EGM51_13760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EGM51_13785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGM51_13790	COG0300	oxidoreductase activity
EGM51_13800	COG3852	Histidine kinase
EGM51_13805	COG2067	long-chain fatty acid transport protein
EGM51_13815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGM51_13820	COG3852	Histidine kinase
EGM51_13835	COG0589	response to stress
EGM51_13840	COG0714	Associated with various cellular activities
EGM51_13865	COG2304	oxidoreductase activity
EGM51_13900	COG0131	Imidazoleglycerol-phosphate dehydratase
EGM51_13905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EGM51_13910	COG4589	Belongs to the CDS family
EGM51_13935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EGM51_13940	COG0071	Belongs to the small heat shock protein (HSP20) family
EGM51_13960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGM51_13965	COG0045	succinate-CoA ligase (ADP-forming) activity
EGM51_13975	COG1053	succinate dehydrogenase
EGM51_14025	COG2161	toxin-antitoxin pair type II binding
EGM51_14040	COG2957	Belongs to the agmatine deiminase family
EGM51_14055	COG0653	protein targeting
EGM51_14060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGM51_14065	COG0288	reversible hydration of carbon dioxide
EGM51_14080	COG0659	secondary active sulfate transmembrane transporter activity
EGM51_14085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EGM51_14105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_14105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGM51_14105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_14115	COG0489	protein tyrosine kinase activity
EGM51_14120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_14130	COG0489	protein tyrosine kinase activity
EGM51_14145	COG1342	Belongs to the UPF0251 family
EGM51_14155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_14170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGM51_14180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EGM51_14200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGM51_14205	COG2723	6-phospho-beta-galactosidase activity
EGM51_14210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM51_14220	COG0778	Nitroreductase
EGM51_14225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGM51_14225	COG3170	Tfp pilus assembly protein FimV
EGM51_14265	COG2221	Nitrite and sulphite reductase 4Fe-4S
EGM51_14270	COG1846	Transcriptional regulator
EGM51_14280	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EGM51_14295	COG2261	transglycosylase associated protein
EGM51_14320	COG0426	domain, Protein
EGM51_14325	COG1959	2 iron, 2 sulfur cluster binding
EGM51_14330	COG1132	(ABC) transporter
EGM51_14335	COG1448	Aminotransferase
EGM51_14345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGM51_14345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM51_14385	COG0490	domain, Protein
EGM51_14385	COG2985	domain, Protein
EGM51_14400	COG4948	Mandelate Racemase Muconate Lactonizing
EGM51_14405	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGM51_14410	COG1609	Transcriptional regulator
EGM51_14420	COG2860	membrane
EGM51_14440	COG0516	GMP reductase activity
EGM51_14445	COG1704	LemA family
EGM51_14490	COG0596	Alpha beta hydrolase
EGM51_14490	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM51_14495	COG0604	alcohol dehydrogenase
EGM51_14520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EGM51_14555	COG0829	nickel cation binding
EGM51_14560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EGM51_14565	COG0830	nickel cation binding
EGM51_14570	COG0804	urea catabolic process
EGM51_14605	COG0683	leucine binding
EGM51_14655	COG1459	type II secretion system
EGM51_14660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_14665	COG1450	Type ii and iii secretion system protein
EGM51_14690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGM51_14695	COG0592	DNA-directed DNA polymerase activity
EGM51_14725	COG0445	tRNA wobble uridine modification
EGM51_14745	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EGM51_14750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGM51_14755	COG0321	lipoyl(octanoyl) transferase activity
EGM51_14755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EGM51_14770	COG1215	transferase activity, transferring glycosyl groups
EGM51_14775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EGM51_14795	COG1070	Carbohydrate kinase
EGM51_14800	COG2115	Belongs to the xylose isomerase family
EGM51_14805	COG0477	Major facilitator Superfamily
EGM51_14835	COG0673	inositol 2-dehydrogenase activity
EGM51_14860	COG0673	inositol 2-dehydrogenase activity
EGM51_14870	COG2207	Transcriptional regulator
EGM51_14870	COG3708	Transcriptional regulator
EGM51_14915	COG1489	DNA binding
EGM51_14945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EGM51_14960	COG0187	DNA topoisomerase II activity
EGM51_14965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EGM51_14980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EGM51_14985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGM51_15000	COG0356	it plays a direct role in the translocation of protons across the membrane
EGM51_15010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EGM51_15015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGM51_15025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EGM51_15030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGM51_15035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EGM51_15045	COG0776	regulation of translation
EGM51_15055	COG0475	glutathione-regulated potassium exporter activity
EGM51_15070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGM51_15085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_15090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_15095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EGM51_15105	COG4628	conserved protein (DUF2132)
EGM51_15140	COG1160	GTP binding
EGM51_15145	COG0501	Belongs to the peptidase M48B family
EGM51_15150	COG1704	LemA family
EGM51_15155	COG0776	regulation of translation
EGM51_15165	COG1505	serine-type exopeptidase activity
EGM51_15175	COG1129	ABC transporter
EGM51_15180	COG4372	Transposase
EGM51_15240	COG0110	maltose O-acetyltransferase activity
EGM51_15270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGM51_15330	COG2251	uridine kinase activity
EGM51_15330	COG0195	Participates in both transcription termination and antitermination
EGM51_15335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EGM51_15345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGM51_15370	COG0134	indole-3-glycerol-phosphate synthase activity
EGM51_15390	COG1450	Type ii and iii secretion system protein
EGM51_15395	COG2176	DNA-directed DNA polymerase activity
EGM51_15405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGM51_15410	COG1595	DNA-templated transcription, initiation
EGM51_15430	COG2226	methyltransferase
EGM51_15440	COG3415	Transposase
EGM51_15440	COG2801	Transposase and inactivated derivatives
EGM51_15445	COG0398	Pfam SNARE associated Golgi protein
EGM51_15475	COG0811	peptide transport
EGM51_15485	COG0848	biopolymer transport protein
EGM51_15505	COG0022	dehydrogenase e1 component
EGM51_15515	COG0004	ammonium transporteR
EGM51_15530	COG0583	DNA-binding transcription factor activity
EGM51_15535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGM51_15550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGM51_15560	COG0745	RESPONSE REGULATOR receiver
EGM51_15570	COG3530	Putative quorum-sensing-regulated virulence factor
EGM51_15585	COG2192	nodulation
EGM51_15590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EGM51_15605	COG1132	(ABC) transporter
EGM51_15625	COG0745	RESPONSE REGULATOR receiver
EGM51_15630	COG2198	Histidine kinase
EGM51_15630	COG0784	Response regulator, receiver
EGM51_15630	COG5002	protein histidine kinase activity
EGM51_15640	COG0438	transferase activity, transferring glycosyl groups
EGM51_15650	COG3279	Response regulator of the LytR AlgR family
EGM51_15670	COG5001	Diguanylate cyclase
EGM51_15680	COG4251	negative regulation of phosphorylation
EGM51_15685	COG0784	Response regulator, receiver
EGM51_15690	COG4191	Histidine kinase
EGM51_15695	COG4191	Histidine kinase
EGM51_15695	COG0784	Response regulator, receiver
EGM51_15705	COG1530	ribonuclease E activity
EGM51_15710	COG0772	Belongs to the SEDS family
EGM51_15715	COG0768	penicillin binding
EGM51_15775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_15805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EGM51_15815	COG2081	HI0933 family
EGM51_15845	COG0484	heat shock protein binding
EGM51_15855	COG1192	Involved in chromosome partitioning
EGM51_15880	COG0673	inositol 2-dehydrogenase activity
EGM51_15890	COG3850	Histidine kinase
EGM51_15920	COG3119	arylsulfatase activity
EGM51_15955	COG3250	beta-galactosidase activity
EGM51_15985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGM51_15990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EGM51_15995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EGM51_16005	COG0742	ribosomal rna small subunit methyltransferase
EGM51_16010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGM51_16015	COG4206	TonB-dependent receptor
EGM51_16025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM51_16030	COG1121	(ABC) transporter
EGM51_16040	COG3746	phosphate-selective porin O and P
EGM51_16060	COG0488	(ABC) transporter
EGM51_16075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGM51_16105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_16160	COG3118	belongs to the thioredoxin family
EGM51_16170	COG0450	alkyl hydroperoxide reductase
EGM51_16190	COG1643	Atp-dependent helicase
EGM51_16195	COG0673	inositol 2-dehydrogenase activity
EGM51_16205	COG0318	PFAM AMP-dependent synthetase and ligase
EGM51_16225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGM51_16230	COG0037	tRNA processing
EGM51_16240	COG0653	protein targeting
EGM51_16260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGM51_16300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_16305	COG0419	ATPase involved in DNA repair
EGM51_16325	COG0420	3'-5' exonuclease activity
EGM51_16330	COG0113	porphobilinogen synthase activity
EGM51_16335	COG0428	transporter
EGM51_16345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGM51_16370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EGM51_16380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGM51_16400	COG4864	UPF0365 protein
EGM51_16410	COG1030	water channel activity
EGM51_16420	COG0148	phosphopyruvate hydratase activity
EGM51_16430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM51_16440	COG0084	hydrolase, TatD family'
EGM51_16490	COG0563	adenylate kinase activity
EGM51_16520	COG2255	four-way junction helicase activity
EGM51_16525	COG0632	four-way junction helicase activity
EGM51_16535	COG0724	RNA recognition motif
EGM51_16580	COG0778	Nitroreductase
EGM51_16585	COG0778	Nitroreductase
EGM51_16590	COG1309	transcriptional regulator
EGM51_16625	COG1337	RAMP superfamily
EGM51_16665	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EGM51_16705	COG0826	peptidase U32
EGM51_16715	COG2022	thiamine diphosphate biosynthetic process
EGM51_16720	COG2104	thiamine diphosphate biosynthetic process
EGM51_16720	COG2022	thiamine diphosphate biosynthetic process
EGM51_16750	COG0823	Involved in the tonB-independent uptake of proteins
EGM51_16765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EGM51_16770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EGM51_16770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGM51_16775	COG0205	6-phosphofructokinase activity
EGM51_16780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGM51_16795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM51_16800	COG3977	Valine--pyruvate aminotransferase
EGM51_16810	COG0640	Transcriptional regulator
EGM51_16825	COG3118	belongs to the thioredoxin family
EGM51_16840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGM51_16855	COG0864	Transcriptional regulator
EGM51_16865	COG3665	Urea carboxylase-associated protein
EGM51_16880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EGM51_16895	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGM51_16915	COG2957	Belongs to the agmatine deiminase family
EGM51_16925	COG1454	alcohol dehydrogenase
EGM51_16950	COG1748	Saccharopine dehydrogenase
EGM51_16970	COG0626	cystathionine gamma-synthase activity
EGM51_16980	COG1166	arginine decarboxylase activity
EGM51_17035	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
EGM51_17065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EGM51_17090	COG1490	D-aminoacyl-tRNA deacylase activity
EGM51_17095	COG0165	Argininosuccinate lyase
EGM51_17115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGM51_17120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGM51_17125	COG0193	aminoacyl-tRNA hydrolase activity
EGM51_17135	COG0629	single-stranded DNA binding
EGM51_17140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGM51_17145	COG0359	binds to the 23S rRNA
EGM51_17150	COG0305	Participates in initiation and elongation during chromosome replication
EGM51_17165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM51_17170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM51_17180	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGM51_17235	COG0180	Tryptophanyl-tRNA synthetase
EGM51_17245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGM51_17250	COG0077	Prephenate dehydratase
EGM51_17250	COG1605	Chorismate mutase
EGM51_17260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_17265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGM51_17280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EGM51_17300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_17305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_17315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGM51_17330	COG0084	hydrolase, TatD family'
EGM51_17350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGM51_17360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGM51_17370	COG1692	metallophosphoesterase
EGM51_17400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGM51_17400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM51_17405	COG1058	Belongs to the CinA family
EGM51_17405	COG1546	Belongs to the CinA family
EGM51_17420	COG1573	uracil-dna glycosylase
EGM51_17435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGM51_17440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGM51_17450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGM51_17460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EGM51_17460	COG0546	phosphoglycolate phosphatase activity
EGM51_17465	COG3030	protein affecting phage T7 exclusion by the F plasmid
EGM51_17475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EGM51_17475	COG0517	IMP dehydrogenase activity
EGM51_17500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGM51_17505	COG0539	negative regulation of cytoplasmic translation
EGM51_17510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGM51_17515	COG0217	transcriptional regulatory protein
EGM51_17525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EGM51_17540	COG1592	Rubrerythrin
EGM51_17550	COG0069	glutamate synthase activity
EGM51_17555	COG0028	Belongs to the TPP enzyme family
EGM51_17575	COG3634	alkyl hydroperoxide reductase activity
EGM51_17580	COG0450	alkyl hydroperoxide reductase
EGM51_17600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EGM51_17605	COG0758	DNA mediated transformation
EGM51_17605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM51_17610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EGM51_17615	COG4974	Belongs to the 'phage' integrase family
EGM51_17660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EGM51_17665	COG0095	Lipoate-protein ligase
EGM51_17675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_17675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_17700	COG1414	Transcriptional regulator
EGM51_17725	COG3507	Belongs to the glycosyl hydrolase 43 family
EGM51_17730	COG3507	Belongs to the glycosyl hydrolase 43 family
EGM51_17735	COG3661	Belongs to the glycosyl hydrolase 67 family
EGM51_17765	COG5492	domain, Protein
EGM51_17800	COG3119	arylsulfatase activity
EGM51_17820	COG3850	Histidine kinase
EGM51_17820	COG5002	protein histidine kinase activity
EGM51_17825	COG0745	RESPONSE REGULATOR receiver
EGM51_17835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGM51_17845	COG1053	succinate dehydrogenase
EGM51_17895	COG4968	Prepilin-type N-terminal cleavage methylation domain
EGM51_17900	COG2204	response regulator
EGM51_17905	COG1459	type II secretion system
EGM51_17910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_17950	COG4796	Type ii and iii secretion system protein
EGM51_17970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGM51_17980	COG2353	YceI-like domain
EGM51_17985	COG0072	phenylalanine-tRNA ligase activity
EGM51_18005	COG1199	ATP-dependent helicase activity
EGM51_18005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGM51_18010	COG2234	aminopeptidase activity
EGM51_18010	COG4935	Belongs to the peptidase S8 family
EGM51_18015	COG2234	aminopeptidase activity
EGM51_18020	COG2234	aminopeptidase activity
EGM51_18030	COG1648	precorrin-2 dehydrogenase activity
EGM51_18030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGM51_18045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGM51_18045	COG1333	cytochrome c biogenesis protein
EGM51_18050	COG4191	Histidine kinase
EGM51_18055	COG2204	response regulator
EGM51_18065	COG2983	Belongs to the UPF0260 family