locus-tag	class	description
VAB18032_00010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
VAB18032_00015	COG5662	AntiSigma factor
VAB18032_00020	COG1595	DNA-templated transcription, initiation
VAB18032_00035	COG2135	peptidase activity
VAB18032_00040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VAB18032_00050	COG0483	inositol monophosphate 1-phosphatase activity
VAB18032_00060	COG0438	transferase activity, transferring glycosyl groups
VAB18032_00075	COG2197	response regulator
VAB18032_00090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAB18032_00100	COG1615	UPF0182 protein
VAB18032_00105	COG3480	Lon protease (S16) C-terminal proteolytic domain
VAB18032_00135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAB18032_00210	COG1278	Cold shock
VAB18032_00230	COG1611	Belongs to the LOG family
VAB18032_00240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAB18032_00245	COG2171	N-acyltransferase activity
VAB18032_00250	COG1404	Belongs to the peptidase S8 family
VAB18032_00275	COG0287	Prephenate dehydrogenase
VAB18032_00290	COG0456	acetyltransferase
VAB18032_00305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VAB18032_00330	COG4608	Belongs to the ABC transporter superfamily
VAB18032_00335	COG0444	Belongs to the ABC transporter superfamily
VAB18032_00380	COG2226	methyltransferase
VAB18032_00390	COG2949	membrane
VAB18032_00395	COG0012	GTP binding
VAB18032_00410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VAB18032_00410	COG2169	Transcriptional regulator
VAB18032_00420	COG1132	(ABC) transporter
VAB18032_00425	COG0525	valine-tRNA ligase activity
VAB18032_00445	COG1131	(ABC) transporter
VAB18032_00455	COG0529	Catalyzes the synthesis of activated sulfate
VAB18032_00485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAB18032_00490	COG0747	negative chemotaxis
VAB18032_00495	COG0601	transmembrane transport
VAB18032_00505	COG0444	Belongs to the ABC transporter superfamily
VAB18032_00510	COG4608	Belongs to the ABC transporter superfamily
VAB18032_00515	COG0138	bifunctional purine biosynthesis protein purh
VAB18032_00565	COG0045	succinate-CoA ligase (ADP-forming) activity
VAB18032_00570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VAB18032_00575	COG0739	heme binding
VAB18032_00580	COG0739	heme binding
VAB18032_00580	COG0741	lytic transglycosylase activity
VAB18032_00580	COG1196	nuclear chromosome segregation
VAB18032_00585	COG0488	(ABC) transporter
VAB18032_00595	COG1605	Chorismate mutase
VAB18032_00600	COG4608	Belongs to the ABC transporter superfamily
VAB18032_00605	COG0444	Belongs to the ABC transporter superfamily
VAB18032_00615	COG0601	transmembrane transport
VAB18032_00625	COG2197	response regulator
VAB18032_00630	COG4585	Histidine kinase
VAB18032_00645	COG0688	phosphatidylethanolamine metabolic process
VAB18032_00650	COG1183	phosphatidylcholine synthase activity
VAB18032_00655	COG1051	belongs to the nudix hydrolase family
VAB18032_00670	COG0519	Catalyzes the synthesis of GMP from XMP
VAB18032_00670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAB18032_00680	COG1316	TRANSCRIPTIONal
VAB18032_00690	COG0516	GMP reductase activity
VAB18032_00705	COG2197	response regulator
VAB18032_00715	COG0459	protein refolding
VAB18032_00730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAB18032_00745	COG4214	carbohydrate transport
VAB18032_00785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAB18032_00795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAB18032_00815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VAB18032_00825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAB18032_00830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VAB18032_00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAB18032_00840	COG2223	nitrite transmembrane transporter activity
VAB18032_00855	COG0243	molybdopterin cofactor binding
VAB18032_00860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAB18032_00865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAB18032_00865	COG2146	nitrite reductase [NAD(P)H] activity
VAB18032_00890	COG2018	Roadblock/LC7 domain
VAB18032_00905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_00935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAB18032_00940	COG0351	phosphomethylpyrimidine kinase
VAB18032_00945	COG0352	thiamine-phosphate diphosphorylase activity
VAB18032_00950	COG2022	thiamine diphosphate biosynthetic process
VAB18032_00965	COG0352	thiamine-phosphate diphosphorylase activity
VAB18032_00970	COG3291	Pkd domain containing protein
VAB18032_00970	COG4412	M6 family metalloprotease domain protein
VAB18032_00975	COG3291	Pkd domain containing protein
VAB18032_00985	COG0667	Aldo Keto reductase
VAB18032_00990	COG0488	(ABC) transporter
VAB18032_00995	COG2813	Specifically methylates the guanine in position
VAB18032_01005	COG0101	tRNA pseudouridine synthase activity
VAB18032_01010	COG0203	ribosomal protein L17
VAB18032_01015	COG0202	RNA polymerase activity
VAB18032_01020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAB18032_01025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAB18032_01030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAB18032_01035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAB18032_01040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAB18032_01055	COG0563	adenylate kinase activity
VAB18032_01065	COG0200	Binds to the 23S rRNA
VAB18032_01070	COG1841	ribosomal large subunit assembly
VAB18032_01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAB18032_01080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VAB18032_01085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAB18032_01090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAB18032_01095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAB18032_01100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAB18032_01105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAB18032_01110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAB18032_01115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAB18032_01120	COG0255	Belongs to the universal ribosomal protein uL29 family
VAB18032_01125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAB18032_01130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VAB18032_01135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VAB18032_01140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAB18032_01145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAB18032_01150	COG0089	rRNA binding
VAB18032_01155	COG0088	Forms part of the polypeptide exit tunnel
VAB18032_01160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAB18032_01165	COG0051	transcription antitermination factor activity, RNA binding
VAB18032_01170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAB18032_01175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAB18032_01180	COG0049	tRNA binding
VAB18032_01185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VAB18032_01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAB18032_01205	COG0085	RNA polymerase activity
VAB18032_01210	COG0222	ribosome binding
VAB18032_01220	COG0081	regulation of translation
VAB18032_01225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VAB18032_01235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAB18032_01245	COG2030	dehydratase
VAB18032_01250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAB18032_01280	COG1666	GTP binding
VAB18032_01295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAB18032_01310	COG0501	Belongs to the peptidase M48B family
VAB18032_01315	COG1007	ATP synthesis coupled electron transport
VAB18032_01330	COG0713	ATP synthesis coupled electron transport
VAB18032_01340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB18032_01350	COG0435	Glutathione S-transferase
VAB18032_01355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VAB18032_01360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB18032_01365	COG1063	alcohol dehydrogenase
VAB18032_01375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB18032_01385	COG2211	Major facilitator Superfamily
VAB18032_01395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAB18032_01400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAB18032_01450	COG0513	Belongs to the DEAD box helicase family
VAB18032_01475	COG0514	ATP-dependent DNA helicase (RecQ)
VAB18032_01520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAB18032_01525	COG0569	domain protein
VAB18032_01530	COG0515	serine threonine protein kinase
VAB18032_01545	COG0483	inositol monophosphate 1-phosphatase activity
VAB18032_01550	COG0784	Response regulator, receiver
VAB18032_01555	COG4251	negative regulation of phosphorylation
VAB18032_01560	COG0745	RESPONSE REGULATOR receiver
VAB18032_01575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAB18032_01595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAB18032_01635	COG1674	ftsk spoiiie
VAB18032_01720	COG0488	(ABC) transporter
VAB18032_01725	COG2226	methyltransferase
VAB18032_01760	COG1648	precorrin-2 dehydrogenase activity
VAB18032_01760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAB18032_01765	COG0181	hydroxymethylbilane synthase activity
VAB18032_01770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAB18032_01775	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
VAB18032_01790	COG1595	DNA-templated transcription, initiation
VAB18032_01800	COG0560	Phosphoserine phosphatase
VAB18032_01825	COG0577	efflux transmembrane transporter activity
VAB18032_01825	COG1136	(ABC) transporter
VAB18032_01830	COG0577	efflux transmembrane transporter activity
VAB18032_01830	COG1136	(ABC) transporter
VAB18032_01850	COG0506	proline dehydrogenase activity
VAB18032_01860	COG0754	glutathionylspermidine amidase activity
VAB18032_01870	COG1082	Xylose isomerase domain protein TIM barrel
VAB18032_01900	COG0588	phosphoglycerate mutase activity
VAB18032_01930	COG0438	transferase activity, transferring glycosyl groups
VAB18032_01945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAB18032_01965	COG0395	ABC-type sugar transport system, permease component
VAB18032_01980	COG0251	oxidation-reduction process
VAB18032_01995	COG1131	(ABC) transporter
VAB18032_02005	COG4585	Histidine kinase
VAB18032_02010	COG2197	response regulator
VAB18032_02030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAB18032_02060	COG3246	L-lysine catabolic process to acetate
VAB18032_02065	COG0354	folic acid binding
VAB18032_02070	COG0735	belongs to the Fur family
VAB18032_02080	COG4044	May play a role in the intracellular transport of hydrophobic ligands
VAB18032_02115	COG1404	Belongs to the peptidase S8 family
VAB18032_02115	COG4412	M6 family metalloprotease domain protein
VAB18032_02135	COG2897	thiosulfate sulfurtransferase activity
VAB18032_02150	COG0745	RESPONSE REGULATOR receiver
VAB18032_02160	COG0456	acetyltransferase
VAB18032_02210	COG2339	peptidase activity
VAB18032_02215	COG4129	membrane
VAB18032_02230	COG0277	FAD linked oxidase domain protein
VAB18032_02240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAB18032_02245	COG1404	Belongs to the peptidase S8 family
VAB18032_02265	COG0459	protein refolding
VAB18032_02275	COG1278	Cold shock
VAB18032_02295	COG0456	acetyltransferase
VAB18032_02295	COG0454	-acetyltransferase
VAB18032_02300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAB18032_02320	COG1131	(ABC) transporter
VAB18032_02335	COG2018	Roadblock/LC7 domain
VAB18032_02355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAB18032_02380	COG1131	(ABC) transporter
VAB18032_02385	COG1349	DNA-binding transcription factor activity
VAB18032_02390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VAB18032_02395	COG1940	carbohydrate kinase activity
VAB18032_02440	COG1024	Enoyl-CoA hydratase
VAB18032_02445	COG3842	ATPase activity
VAB18032_02450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAB18032_02455	COG0215	cysteine-tRNA ligase activity
VAB18032_02510	COG0114	fumarate hydratase activity
VAB18032_02525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
VAB18032_02525	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
VAB18032_02550	COG3185	4-Hydroxyphenylpyruvate dioxygenase
VAB18032_02565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAB18032_02600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAB18032_02605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAB18032_02635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAB18032_02650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAB18032_02655	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
VAB18032_02665	COG0242	peptide deformylase activity
VAB18032_02670	COG3830	Belongs to the UPF0237 family
VAB18032_02675	COG1194	a g-specific adenine glycosylase
VAB18032_02685	COG0542	response to heat
VAB18032_02695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAB18032_02700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VAB18032_02710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAB18032_02720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VAB18032_02725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAB18032_02740	COG0649	NAD binding
VAB18032_02750	COG1732	Glycine betaine
VAB18032_02755	COG1174	glycine betaine transport
VAB18032_02760	COG1174	glycine betaine transport
VAB18032_02830	COG1196	nuclear chromosome segregation
VAB18032_02830	COG0741	lytic transglycosylase activity
VAB18032_02830	COG0739	heme binding
VAB18032_02855	COG0302	gtp cyclohydrolase
VAB18032_02860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAB18032_02875	COG4977	sequence-specific DNA binding
VAB18032_02880	COG0037	tRNA processing
VAB18032_02890	COG2027	D-alanyl-D-alanine carboxypeptidase
VAB18032_02895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAB18032_02905	COG1674	ftsk spoiiie
VAB18032_02910	COG1404	Belongs to the peptidase S8 family
VAB18032_02915	COG0671	phosphoesterase, PA-phosphatase related
VAB18032_02930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAB18032_02935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAB18032_02940	COG2843	Capsule synthesis protein
VAB18032_02965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAB18032_03045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAB18032_03050	COG1610	YqeY-like protein
VAB18032_03055	COG1408	metallophosphoesterase
VAB18032_03070	COG2192	nodulation
VAB18032_03080	COG1280	lysine exporter protein (LysE YggA)
VAB18032_03110	COG0133	tryptophan synthase activity
VAB18032_03115	COG0159	tryptophan synthase activity
VAB18032_03155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAB18032_03160	COG0745	RESPONSE REGULATOR receiver
VAB18032_03160	COG3706	GGDEF domain
VAB18032_03185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAB18032_03190	COG0477	Major facilitator Superfamily
VAB18032_03205	COG4608	Belongs to the ABC transporter superfamily
VAB18032_03210	COG0444	Belongs to the ABC transporter superfamily
VAB18032_03225	COG0747	negative chemotaxis
VAB18032_03230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAB18032_03235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAB18032_03280	COG0411	ABC transporter
VAB18032_03285	COG0410	ABC transporter
VAB18032_03300	COG0506	proline dehydrogenase activity
VAB18032_03305	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_03340	COG0813	purine-nucleoside phosphorylase activity
VAB18032_03355	COG0590	tRNA wobble adenosine to inosine editing
VAB18032_03385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VAB18032_03385	COG1796	DNA polymerase
VAB18032_03390	COG0697	spore germination
VAB18032_03410	COG4981	capsule polysaccharide biosynthetic process
VAB18032_03420	COG0438	transferase activity, transferring glycosyl groups
VAB18032_03520	COG1674	ftsk spoiiie
VAB18032_03560	COG0464	growth
VAB18032_03595	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_03650	COG0367	asparagine synthase
VAB18032_03655	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VAB18032_03660	COG3546	catalase activity
VAB18032_03665	COG3693	PFAM glycoside hydrolase, family 10
VAB18032_03670	COG0577	efflux transmembrane transporter activity
VAB18032_03675	COG1136	(ABC) transporter
VAB18032_03750	COG1881	PFAM PEBP family protein
VAB18032_03760	COG0546	phosphoglycolate phosphatase activity
VAB18032_03785	COG1051	belongs to the nudix hydrolase family
VAB18032_03805	COG1674	ftsk spoiiie
VAB18032_03850	COG0789	Transcriptional regulator
VAB18032_03855	COG3959	Transketolase, thiamine diphosphate binding domain
VAB18032_03860	COG3958	Transketolase
VAB18032_03865	COG0463	Glycosyl transferase, family 2
VAB18032_03885	COG0183	Belongs to the thiolase family
VAB18032_03895	COG0705	Rhomboid family
VAB18032_03910	COG0598	Magnesium transport protein CorA
VAB18032_03915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAB18032_03940	COG0371	Dehydrogenase
VAB18032_03960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAB18032_03965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAB18032_03970	COG3275	phosphorelay sensor kinase activity
VAB18032_03975	COG3279	Response regulator of the LytR AlgR family
VAB18032_03985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAB18032_04015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAB18032_04020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAB18032_04050	COG5002	protein histidine kinase activity
VAB18032_04065	COG2235	arginine
VAB18032_04100	COG1764	response to oxidative stress
VAB18032_04110	COG0561	phosphatase activity
VAB18032_04115	COG0561	phosphatase activity
VAB18032_04135	COG1834	amidinotransferase
VAB18032_04140	COG1522	sequence-specific DNA binding
VAB18032_04165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAB18032_04185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAB18032_04195	COG1408	metallophosphoesterase
VAB18032_04255	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAB18032_04260	COG0315	cyclic pyranopterin monophosphate synthase activity
VAB18032_04265	COG3629	intracellular signal transduction
VAB18032_04265	COG3903	Transcriptional regulator
VAB18032_04300	COG0359	binds to the 23S rRNA
VAB18032_04305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VAB18032_04315	COG0360	Binds together with S18 to 16S ribosomal RNA
VAB18032_04320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VAB18032_04335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAB18032_04345	COG1695	Transcriptional regulator
VAB18032_04350	COG1260	myo-inositol-1-phosphate synthase
VAB18032_04360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VAB18032_04370	COG0617	tRNA 3'-terminal CCA addition
VAB18032_04385	COG1595	DNA-templated transcription, initiation
VAB18032_04400	COG3118	belongs to the thioredoxin family
VAB18032_04405	COG3409	Peptidoglycan-binding domain 1 protein
VAB18032_04405	COG0860	N-Acetylmuramoyl-L-alanine amidase
VAB18032_04415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAB18032_04420	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAB18032_04435	COG1192	Involved in chromosome partitioning
VAB18032_04440	COG0357	Ribosomal RNA small subunit methyltransferase G
VAB18032_04450	COG0706	membrane insertase activity
VAB18032_04455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VAB18032_04460	COG0594	ribonuclease P activity
VAB18032_04465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VAB18032_04470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAB18032_04475	COG0592	DNA-directed DNA polymerase activity
VAB18032_04480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
VAB18032_04485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VAB18032_04490	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
VAB18032_04505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VAB18032_04520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAB18032_04580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAB18032_04610	COG0789	Transcriptional regulator
VAB18032_04620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VAB18032_04650	COG0517	IMP dehydrogenase activity
VAB18032_04655	COG0442	prolyl-tRNA aminoacylation
VAB18032_04660	COG2197	response regulator
VAB18032_04665	COG4585	Histidine kinase
VAB18032_04705	COG0439	Biotin carboxylase
VAB18032_04710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAB18032_04715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAB18032_04720	COG1960	acyl-CoA dehydrogenase activity
VAB18032_04730	COG1846	Transcriptional regulator
VAB18032_04735	COG2353	YceI-like domain
VAB18032_04805	COG1716	ATPase activity
VAB18032_04805	COG1716	ATPase activity
VAB18032_04810	COG1716	ATPase activity
VAB18032_04825	COG0768	penicillin binding
VAB18032_04830	COG0515	serine threonine protein kinase
VAB18032_04835	COG2815	serine threonine protein kinase
VAB18032_04835	COG0515	serine threonine protein kinase
VAB18032_04855	COG3764	Sortase (surface protein transpeptidase)
VAB18032_04870	COG0247	lactate metabolic process
VAB18032_04870	COG2181	nitrate reductase activity
VAB18032_04885	COG0717	Belongs to the dCTP deaminase family
VAB18032_04900	COG2910	NAD(P)H-binding
VAB18032_04905	COG1733	regulation of RNA biosynthetic process
VAB18032_04950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VAB18032_04960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAB18032_04970	COG1960	acyl-CoA dehydrogenase activity
VAB18032_04980	COG2062	phosphohistidine phosphatase, SixA
VAB18032_04995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VAB18032_05005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAB18032_05030	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAB18032_05035	COG0022	dehydrogenase e1 component
VAB18032_05075	COG0443	Heat shock 70 kDa protein
VAB18032_05080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAB18032_05085	COG0484	heat shock protein binding
VAB18032_05090	COG0789	Transcriptional regulator
VAB18032_05110	COG0542	response to heat
VAB18032_05140	COG0640	Transcriptional regulator
VAB18032_05150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VAB18032_05165	COG1950	PFAM Membrane protein of
VAB18032_05170	COG0191	fructose-bisphosphate aldolase activity
VAB18032_05195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAB18032_05200	COG0151	Belongs to the GarS family
VAB18032_05260	COG0318	PFAM AMP-dependent synthetase and ligase
VAB18032_05265	COG1960	acyl-CoA dehydrogenase activity
VAB18032_05300	COG1051	belongs to the nudix hydrolase family
VAB18032_05310	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_05315	COG0183	Belongs to the thiolase family
VAB18032_05325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAB18032_05330	COG0393	Putative heavy-metal-binding
VAB18032_05340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAB18032_05345	COG0047	phosphoribosylformylglycinamidine synthase activity
VAB18032_05350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAB18032_05375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAB18032_05380	COG0641	radical SAM
VAB18032_05425	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAB18032_05430	COG1024	Enoyl-CoA hydratase
VAB18032_05460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
VAB18032_05650	COG1051	belongs to the nudix hydrolase family
VAB18032_05690	COG2189	Belongs to the N(4) N(6)-methyltransferase family
VAB18032_05735	COG1121	(ABC) transporter
VAB18032_05750	COG4566	intracellular signal transduction
VAB18032_05760	COG3135	benzoate transporter
VAB18032_05780	COG2186	Transcriptional regulator
VAB18032_05785	COG2807	transmembrane transport
VAB18032_05795	COG1366	Belongs to the anti-sigma-factor antagonist family
VAB18032_05800	COG1366	Belongs to the anti-sigma-factor antagonist family
VAB18032_05805	COG2172	sigma factor antagonist activity
VAB18032_05815	COG2205	protein histidine kinase activity
VAB18032_05820	COG0745	RESPONSE REGULATOR receiver
VAB18032_05850	COG0277	FAD linked oxidase domain protein
VAB18032_05860	COG2205	protein histidine kinase activity
VAB18032_05860	COG0784	Response regulator, receiver
VAB18032_05870	COG1366	Belongs to the anti-sigma-factor antagonist family
VAB18032_05875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAB18032_05880	COG0406	alpha-ribazole phosphatase activity
VAB18032_05885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAB18032_05890	COG0785	Cytochrome C biogenesis protein
VAB18032_05900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAB18032_05910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VAB18032_05915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAB18032_05925	COG0163	prenyltransferase activity
VAB18032_05935	COG1522	sequence-specific DNA binding
VAB18032_05950	COG0513	Belongs to the DEAD box helicase family
VAB18032_05965	COG0791	NLP P60 protein
VAB18032_05970	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VAB18032_05990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAB18032_05995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB18032_06000	COG1120	ATPase activity
VAB18032_06030	COG1131	(ABC) transporter
VAB18032_06035	COG3973	AAA domain
VAB18032_06040	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
VAB18032_06055	COG3396	Phenylacetate-CoA oxygenase
VAB18032_06060	COG3460	Phenylacetate-CoA oxygenase
VAB18032_06065	COG3396	Phenylacetate-CoA oxygenase
VAB18032_06070	COG2151	metal-sulfur cluster biosynthetic enzyme
VAB18032_06075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAB18032_06080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VAB18032_06090	COG2226	methyltransferase
VAB18032_06110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB18032_06115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB18032_06120	COG0649	NAD binding
VAB18032_06135	COG1034	ATP synthesis coupled electron transport
VAB18032_06145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB18032_06155	COG0713	ATP synthesis coupled electron transport
VAB18032_06170	COG1007	ATP synthesis coupled electron transport
VAB18032_06215	COG1950	PFAM Membrane protein of
VAB18032_06255	COG3291	Pkd domain containing protein
VAB18032_06255	COG4412	M6 family metalloprotease domain protein
VAB18032_06260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAB18032_06330	COG1205	dead DEAH box helicase
VAB18032_06330	COG1111	helicase
VAB18032_06335	COG1366	Belongs to the anti-sigma-factor antagonist family
VAB18032_06345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
VAB18032_06365	COG1754	DNA topoisomerase type I activity
VAB18032_06365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAB18032_06380	COG1309	transcriptional regulator
VAB18032_06390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAB18032_06395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VAB18032_06415	COG1774	PSP1 C-terminal conserved region
VAB18032_06460	COG0859	PFAM glycosyl transferase family 9
VAB18032_06475	COG0693	protein deglycase activity
VAB18032_06490	COG1063	alcohol dehydrogenase
VAB18032_06495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB18032_06510	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
VAB18032_06520	COG1793	dna ligase
VAB18032_06520	COG3285	dna ligase
VAB18032_06545	COG1061	Type III restriction enzyme res subunit
VAB18032_06565	COG1278	Cold shock
VAB18032_06570	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
VAB18032_06575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAB18032_06580	COG2814	Major facilitator Superfamily
VAB18032_06595	COG2252	PERMEase
VAB18032_06605	COG2814	Major facilitator Superfamily
VAB18032_06615	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
VAB18032_06625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAB18032_06635	COG0259	pyridoxamine-phosphate oxidase activity
VAB18032_06645	COG2017	converts alpha-aldose to the beta-anomer
VAB18032_06670	COG1760	l-serine dehydratase
VAB18032_06690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
VAB18032_06695	COG3842	ATPase activity
VAB18032_06755	COG1937	Protein conserved in bacteria
VAB18032_06775	COG3237	CsbD-like
VAB18032_06800	COG3387	PFAM Glycoside hydrolase 15-related
VAB18032_06820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAB18032_06825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAB18032_06830	COG1742	UPF0060 membrane protein
VAB18032_06855	COG2837	iron assimilation
VAB18032_06880	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAB18032_06905	COG2217	Heavy metal translocating P-type atpase
VAB18032_06915	COG1595	DNA-templated transcription, initiation
VAB18032_06920	COG4941	Belongs to the sigma-70 factor family
VAB18032_06940	COG0477	Major facilitator Superfamily
VAB18032_06945	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_06960	COG2813	Specifically methylates the guanine in position
VAB18032_06970	COG0431	NADPH-dependent FMN reductase
VAB18032_06995	COG2124	cytochrome p450
VAB18032_07010	COG3433	isochorismatase activity
VAB18032_07010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_07010	COG2226	methyltransferase
VAB18032_07015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_07035	COG0318	PFAM AMP-dependent synthetase and ligase
VAB18032_07040	COG2867	negative regulation of translational initiation
VAB18032_07040	COG2226	methyltransferase
VAB18032_07050	COG1960	acyl-CoA dehydrogenase activity
VAB18032_07055	COG1960	acyl-CoA dehydrogenase activity
VAB18032_07060	COG2124	cytochrome p450
VAB18032_07080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_07090	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_07100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAB18032_07105	COG2124	cytochrome p450
VAB18032_07115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAB18032_07120	COG1021	2,3-dihydroxybenzoate-AMP ligase
VAB18032_07130	COG0183	Belongs to the thiolase family
VAB18032_07135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAB18032_07150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAB18032_07155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAB18032_07160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAB18032_07200	COG0318	PFAM AMP-dependent synthetase and ligase
VAB18032_07225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_07245	COG3457	Alanine racemase
VAB18032_07250	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_07270	COG1940	carbohydrate kinase activity
VAB18032_07270	COG1846	Transcriptional regulator
VAB18032_07370	COG0410	ABC transporter
VAB18032_07375	COG2226	methyltransferase
VAB18032_07440	COG2189	Belongs to the N(4) N(6)-methyltransferase family
VAB18032_07475	COG2823	Periplasmic or secreted lipoprotein
VAB18032_07590	COG0741	lytic transglycosylase activity
VAB18032_07590	COG0739	heme binding
VAB18032_07590	COG1196	nuclear chromosome segregation
VAB18032_07660	COG0443	Heat shock 70 kDa protein
VAB18032_07675	COG3293	Transposase
VAB18032_07730	COG2801	Transposase and inactivated derivatives
VAB18032_07765	COG2801	Transposase and inactivated derivatives
VAB18032_07790	COG0154	amidase activity
VAB18032_07805	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_07805	COG0604	alcohol dehydrogenase
VAB18032_07805	COG3321	synthase
VAB18032_07835	COG0789	Transcriptional regulator
VAB18032_07860	COG0010	Belongs to the arginase family
VAB18032_07870	COG0110	maltose O-acetyltransferase activity
VAB18032_07880	COG4977	sequence-specific DNA binding
VAB18032_07900	COG0577	efflux transmembrane transporter activity
VAB18032_07900	COG1136	(ABC) transporter
VAB18032_07905	COG1136	(ABC) transporter
VAB18032_07920	COG0745	RESPONSE REGULATOR receiver
VAB18032_07925	COG2205	protein histidine kinase activity
VAB18032_07940	COG1309	transcriptional regulator
VAB18032_07965	COG3629	intracellular signal transduction
VAB18032_07965	COG3903	Transcriptional regulator
VAB18032_08000	COG4585	Histidine kinase
VAB18032_08005	COG2197	response regulator
VAB18032_08020	COG0740	serine-type endopeptidase activity
VAB18032_08030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAB18032_08035	COG1013	pyruvate-flavodoxin oxidoreductase activity
VAB18032_08040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VAB18032_08040	COG0674	pyruvate-flavodoxin oxidoreductase activity
VAB18032_08045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB18032_08050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VAB18032_08065	COG0519	Catalyzes the synthesis of GMP from XMP
VAB18032_08075	COG1024	Enoyl-CoA hydratase
VAB18032_08090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAB18032_08095	COG4122	O-methyltransferase activity
VAB18032_08100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAB18032_08105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAB18032_08120	COG2239	Acts as a magnesium transporter
VAB18032_08125	COG0384	phenazine biosynthesis protein PhzF
VAB18032_08145	COG0454	-acetyltransferase
VAB18032_08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAB18032_08210	COG1595	DNA-templated transcription, initiation
VAB18032_08220	COG0613	PHP domain protein
VAB18032_08225	COG2095	MarC family integral membrane protein
VAB18032_08265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAB18032_08270	COG0745	RESPONSE REGULATOR receiver
VAB18032_08270	COG3706	GGDEF domain
VAB18032_08275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VAB18032_08280	COG0303	'Molybdopterin
VAB18032_08300	COG0789	Transcriptional regulator
VAB18032_08310	COG3795	YCII-related domain
VAB18032_08315	COG4941	Belongs to the sigma-70 factor family
VAB18032_08320	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_08325	COG1832	CoA-binding protein
VAB18032_08335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAB18032_08345	COG2072	flavoprotein involved in K transport
VAB18032_08350	COG0583	DNA-binding transcription factor activity
VAB18032_08360	COG3940	Belongs to the glycosyl hydrolase 43 family
VAB18032_08385	COG0395	ABC-type sugar transport system, permease component
VAB18032_08390	COG4209	transmembrane transport
VAB18032_08445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAB18032_08450	COG2267	carboxylic ester hydrolase activity
VAB18032_08460	COG0084	hydrolase, TatD family'
VAB18032_08465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAB18032_08470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAB18032_08475	COG0488	(ABC) transporter
VAB18032_08505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAB18032_08510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAB18032_08515	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAB18032_08520	COG0193	aminoacyl-tRNA hydrolase activity
VAB18032_08525	COG1218	3'(2'),5'-bisphosphate nucleotidase
VAB18032_08540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VAB18032_08545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAB18032_08555	COG0180	Tryptophanyl-tRNA synthetase
VAB18032_08575	COG0366	Alpha amylase catalytic
VAB18032_08595	COG3833	ABC-type maltose transport systems, permease component
VAB18032_08645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAB18032_08660	COG2018	Roadblock/LC7 domain
VAB18032_08685	COG1695	Transcriptional regulator
VAB18032_08700	COG4988	ABC transporter
VAB18032_08710	COG1271	oxidase subunit
VAB18032_08725	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_08730	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_08735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAB18032_08740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAB18032_08750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAB18032_08755	COG0515	serine threonine protein kinase
VAB18032_08755	COG2815	serine threonine protein kinase
VAB18032_08765	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VAB18032_08765	COG1473	amidohydrolase
VAB18032_08820	COG1846	Transcriptional regulator
VAB18032_08840	COG4770	biotin carboxylase activity
VAB18032_08865	COG4221	oxidoreductase activity
VAB18032_08885	COG0424	maF-like protein
VAB18032_08890	COG1404	Belongs to the peptidase S8 family
VAB18032_08905	COG0515	serine threonine protein kinase
VAB18032_08905	COG2815	serine threonine protein kinase
VAB18032_08930	COG1595	DNA-templated transcription, initiation
VAB18032_08940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAB18032_08965	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VAB18032_08975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VAB18032_08980	COG0561	phosphatase activity
VAB18032_08980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB18032_09005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAB18032_09055	COG1722	exodeoxyribonuclease VII activity
VAB18032_09070	COG1570	exodeoxyribonuclease VII activity
VAB18032_09075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAB18032_09095	COG1322	Protein conserved in bacteria
VAB18032_09105	COG1940	carbohydrate kinase activity
VAB18032_09110	COG1840	ABC-type Fe3 transport system, periplasmic component
VAB18032_09115	COG3842	ATPase activity
VAB18032_09130	COG0165	Argininosuccinate lyase
VAB18032_09140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAB18032_09175	COG0148	phosphopyruvate hydratase activity
VAB18032_09190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAB18032_09220	COG3654	unkown
VAB18032_09245	COG0714	Associated with various cellular activities
VAB18032_09275	COG0183	Belongs to the thiolase family
VAB18032_09300	COG0456	acetyltransferase
VAB18032_09300	COG0454	-acetyltransferase
VAB18032_09305	COG1234	tRNA 3'-trailer cleavage
VAB18032_09310	COG1363	Peptidase, m42
VAB18032_09315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAB18032_09315	COG0189	ligase activity
VAB18032_09320	COG0367	asparagine synthase
VAB18032_09325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAB18032_09330	COG0537	adenosine 5'-monophosphoramidase activity
VAB18032_09350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAB18032_09355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAB18032_09365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VAB18032_09380	COG1331	Highly conserved protein containing a thioredoxin domain
VAB18032_09410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VAB18032_09425	COG1607	acyl-coa hydrolase
VAB18032_09430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAB18032_09440	COG0438	transferase activity, transferring glycosyl groups
VAB18032_09445	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VAB18032_09445	COG0662	Cupin 2, conserved barrel domain protein
VAB18032_09475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VAB18032_09510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAB18032_09515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAB18032_09530	COG1522	sequence-specific DNA binding
VAB18032_09540	COG3842	ATPase activity
VAB18032_09545	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAB18032_09550	COG1177	transmembrane transport
VAB18032_09575	COG0745	RESPONSE REGULATOR receiver
VAB18032_09580	COG2205	protein histidine kinase activity
VAB18032_09595	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAB18032_09615	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_09620	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_09645	COG2318	DinB family
VAB18032_09655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAB18032_09660	COG2835	tetraacyldisaccharide 4'-kinase activity
VAB18032_09675	COG1482	cell wall glycoprotein biosynthetic process
VAB18032_09680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VAB18032_09705	COG0714	Associated with various cellular activities
VAB18032_09725	COG0745	RESPONSE REGULATOR receiver
VAB18032_09730	COG5002	protein histidine kinase activity
VAB18032_09745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAB18032_09760	COG0653	protein targeting
VAB18032_09785	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_09795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAB18032_09800	COG2884	Cell division ATP-binding protein ftsE
VAB18032_09805	COG2177	Part of the ABC transporter FtsEX involved in
VAB18032_09810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAB18032_09825	COG1678	Uncharacterized ACR, COG1678
VAB18032_09855	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
VAB18032_09860	COG4867	von Willebrand factor, type A
VAB18032_09890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAB18032_09920	COG0789	Transcriptional regulator
VAB18032_09940	COG4941	Belongs to the sigma-70 factor family
VAB18032_09950	COG3795	YCII-related domain
VAB18032_09960	COG2814	Major facilitator Superfamily
VAB18032_10020	COG0543	2 iron, 2 sulfur cluster binding
VAB18032_10020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAB18032_10110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAB18032_10120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAB18032_10135	COG0656	L-ascorbic acid biosynthetic process
VAB18032_10140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAB18032_10190	COG2197	response regulator
VAB18032_10220	COG2234	aminopeptidase activity
VAB18032_10275	COG2205	protein histidine kinase activity
VAB18032_10280	COG0745	RESPONSE REGULATOR receiver
VAB18032_10300	COG3387	PFAM Glycoside hydrolase 15-related
VAB18032_10325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_10330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAB18032_10340	COG1335	isochorismatase
VAB18032_10345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAB18032_10350	COG2197	response regulator
VAB18032_10360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAB18032_10385	COG1234	tRNA 3'-trailer cleavage
VAB18032_10390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VAB18032_10395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAB18032_10400	COG2986	histidine ammonia-lyase
VAB18032_10405	COG1228	amidohydrolase
VAB18032_10410	COG0402	S-adenosylhomocysteine deaminase activity
VAB18032_10415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAB18032_10420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAB18032_10435	COG0297	glycogen (starch) synthase activity
VAB18032_10440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAB18032_10440	COG2755	lipolytic protein G-D-S-L family
VAB18032_10470	COG1316	TRANSCRIPTIONal
VAB18032_10500	COG0310	cobalt ion transport
VAB18032_10515	COG1122	ATPase activity
VAB18032_10525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAB18032_10555	COG5650	phosphatidylinositol metabolic process
VAB18032_10560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAB18032_10570	COG0747	negative chemotaxis
VAB18032_10575	COG0601	transmembrane transport
VAB18032_10580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAB18032_10590	COG0596	Alpha beta hydrolase
VAB18032_10600	COG4608	Belongs to the ABC transporter superfamily
VAB18032_10615	COG1376	ErfK ybiS ycfS ynhG family protein
VAB18032_10620	COG1376	ErfK ybiS ycfS ynhG family protein
VAB18032_10625	COG1819	glycosyl
VAB18032_10650	COG1216	Glycosyl transferase, family 2
VAB18032_10655	COG1132	(ABC) transporter
VAB18032_10665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAB18032_10670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAB18032_10730	COG1216	Glycosyl transferase, family 2
VAB18032_10745	COG3903	Transcriptional regulator
VAB18032_10745	COG3629	intracellular signal transduction
VAB18032_10750	COG1215	transferase activity, transferring glycosyl groups
VAB18032_10765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAB18032_10770	COG0297	glycogen (starch) synthase activity
VAB18032_10775	COG0656	L-ascorbic acid biosynthetic process
VAB18032_10785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_10790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_10795	COG1116	anion transmembrane transporter activity
VAB18032_10820	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_10875	COG0596	Alpha beta hydrolase
VAB18032_10945	COG1131	(ABC) transporter
VAB18032_10950	COG1119	ATPase activity
VAB18032_10955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAB18032_10960	COG4977	sequence-specific DNA binding
VAB18032_11010	COG2149	membrane
VAB18032_11030	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VAB18032_11040	COG1595	DNA-templated transcription, initiation
VAB18032_11060	COG0482	sulfurtransferase activity
VAB18032_11080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAB18032_11090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAB18032_11095	COG0154	amidase activity
VAB18032_11105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAB18032_11110	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAB18032_11120	COG2133	pyrroloquinoline quinone binding
VAB18032_11140	COG1609	Transcriptional regulator
VAB18032_11155	COG0395	ABC-type sugar transport system, permease component
VAB18032_11175	COG0659	secondary active sulfate transmembrane transporter activity
VAB18032_11185	COG0129	dihydroxy-acid dehydratase activity
VAB18032_11200	COG0440	acetolactate synthase activity
VAB18032_11205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAB18032_11210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAB18032_11225	COG0473	3-isopropylmalate dehydrogenase activity
VAB18032_11230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAB18032_11245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAB18032_11260	COG0714	Associated with various cellular activities
VAB18032_11270	COG2304	oxidoreductase activity
VAB18032_11285	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAB18032_11305	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAB18032_11315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAB18032_11320	COG0066	3-isopropylmalate dehydratase activity
VAB18032_11325	COG0776	regulation of translation
VAB18032_11340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VAB18032_11360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAB18032_11365	COG0626	cystathionine gamma-synthase activity
VAB18032_11370	COG2890	protein-(glutamine-N5) methyltransferase activity
VAB18032_11420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAB18032_11445	COG0742	ribosomal rna small subunit methyltransferase
VAB18032_11450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAB18032_11465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAB18032_11470	COG0416	fatty acid biosynthetic process
VAB18032_11475	COG0571	ribonuclease III activity
VAB18032_11480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAB18032_11490	COG2340	Cysteine-rich secretory protein family
VAB18032_11510	COG2318	DinB family
VAB18032_11525	COG1846	Transcriptional regulator
VAB18032_11555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAB18032_11570	COG0442	prolyl-tRNA aminoacylation
VAB18032_11580	COG0228	four-way junction DNA binding
VAB18032_11585	COG1837	Belongs to the UPF0109 family
VAB18032_11590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAB18032_11595	COG0336	Belongs to the RNA methyltransferase TrmD family
VAB18032_11600	COG0335	large ribosomal subunit rRNA binding
VAB18032_11605	COG0681	Belongs to the peptidase S26 family
VAB18032_11610	COG0681	Belongs to the peptidase S26 family
VAB18032_11620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VAB18032_11635	COG0156	8-amino-7-oxononanoate synthase activity
VAB18032_11640	COG4974	Belongs to the 'phage' integrase family
VAB18032_11650	COG0606	chelatase, subunit chli
VAB18032_11655	COG0792	nuclease activity
VAB18032_11665	COG0052	Belongs to the universal ribosomal protein uS2 family
VAB18032_11670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAB18032_11675	COG0528	UMP kinase activity
VAB18032_11680	COG0233	cytoplasmic translational termination
VAB18032_11685	COG0575	Belongs to the CDS family
VAB18032_11690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VAB18032_11705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VAB18032_11705	COG2146	nitrite reductase [NAD(P)H] activity
VAB18032_11735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAB18032_11740	COG1515	deoxyribonuclease V activity
VAB18032_11750	COG0750	zinc metalloprotease
VAB18032_11755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAB18032_11770	COG1902	pentaerythritol trinitrate reductase activity
VAB18032_11780	COG0435	Glutathione S-transferase
VAB18032_11785	COG0183	Belongs to the thiolase family
VAB18032_11845	COG1846	Transcriptional regulator
VAB18032_11850	COG0789	Transcriptional regulator
VAB18032_11880	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_11920	COG0577	efflux transmembrane transporter activity
VAB18032_11920	COG1136	(ABC) transporter
VAB18032_11940	COG0779	Required for maturation of 30S ribosomal subunits
VAB18032_11955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAB18032_11965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VAB18032_11970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VAB18032_11995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAB18032_12005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAB18032_12010	COG1185	polyribonucleotide nucleotidyltransferase activity
VAB18032_12015	COG0612	Peptidase, M16
VAB18032_12020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VAB18032_12040	COG3214	Protein conserved in bacteria
VAB18032_12050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
VAB18032_12055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAB18032_12060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
VAB18032_12080	COG1674	ftsk spoiiie
VAB18032_12090	COG2076	Multidrug Resistance protein
VAB18032_12100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAB18032_12110	COG1058	Belongs to the CinA family
VAB18032_12110	COG1546	Belongs to the CinA family
VAB18032_12130	COG2132	Multicopper oxidase
VAB18032_12135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAB18032_12140	COG4991	sh3 domain protein
VAB18032_12160	COG1201	RNA secondary structure unwinding
VAB18032_12170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAB18032_12170	COG2111	Na H antiporter
VAB18032_12190	COG2212	antiporter activity
VAB18032_12195	COG1320	monovalent cation:proton antiporter activity
VAB18032_12205	COG1253	flavin adenine dinucleotide binding
VAB18032_12210	COG4326	sporulation control protein
VAB18032_12230	COG1573	uracil-dna glycosylase
VAB18032_12235	COG0477	Major facilitator Superfamily
VAB18032_12245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAB18032_12245	COG1372	Participates in initiation and elongation during chromosome replication
VAB18032_12250	COG2137	regulation of response to DNA damage stimulus
VAB18032_12260	COG1418	mRNA catabolic process
VAB18032_12275	COG3409	Peptidoglycan-binding domain 1 protein
VAB18032_12280	COG0577	efflux transmembrane transporter activity
VAB18032_12290	COG1136	(ABC) transporter
VAB18032_12310	COG0765	amino acid transport
VAB18032_12315	COG0765	amino acid transport
VAB18032_12320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB18032_12325	COG1126	abc transporter atp-binding protein
VAB18032_12345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAB18032_12355	COG1196	nuclear chromosome segregation
VAB18032_12365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAB18032_12370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAB18032_12380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAB18032_12395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAB18032_12400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAB18032_12485	COG1490	D-aminoacyl-tRNA deacylase activity
VAB18032_12500	COG3842	ATPase activity
VAB18032_12505	COG1178	ABC-type Fe3 transport system permease component
VAB18032_12510	COG1840	ABC-type Fe3 transport system, periplasmic component
VAB18032_12545	COG2313	pseudouridylate synthase activity
VAB18032_12555	COG2860	membrane
VAB18032_12575	COG0483	inositol monophosphate 1-phosphatase activity
VAB18032_12600	COG0756	dUTP diphosphatase activity
VAB18032_12625	COG0569	domain protein
VAB18032_12630	COG0531	amino acid
VAB18032_12635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAB18032_12640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAB18032_12675	COG0745	RESPONSE REGULATOR receiver
VAB18032_12680	COG2205	protein histidine kinase activity
VAB18032_12710	COG1024	Enoyl-CoA hydratase
VAB18032_12710	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAB18032_12715	COG0183	Belongs to the thiolase family
VAB18032_12720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VAB18032_12730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAB18032_12775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAB18032_12780	COG1793	dna ligase
VAB18032_12780	COG3285	dna ligase
VAB18032_12810	COG1733	regulation of RNA biosynthetic process
VAB18032_12830	COG1793	dna ligase
VAB18032_12845	COG0438	transferase activity, transferring glycosyl groups
VAB18032_12850	COG0438	transferase activity, transferring glycosyl groups
VAB18032_12860	COG0438	transferase activity, transferring glycosyl groups
VAB18032_12895	COG0419	ATPase involved in DNA repair
VAB18032_12900	COG0420	3'-5' exonuclease activity
VAB18032_12930	COG1175	transmembrane transport
VAB18032_12935	COG0395	ABC-type sugar transport system, permease component
VAB18032_12950	COG1960	acyl-CoA dehydrogenase activity
VAB18032_12990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAB18032_13000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAB18032_13010	COG2264	protein methyltransferase activity
VAB18032_13035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_13060	COG0726	polysaccharide deacetylase
VAB18032_13075	COG1609	Transcriptional regulator
VAB18032_13080	COG1609	Transcriptional regulator
VAB18032_13120	COG0589	response to stress
VAB18032_13140	COG0542	response to heat
VAB18032_13145	COG1803	Methylglyoxal synthase
VAB18032_13145	COG1597	lipid kinase activity
VAB18032_13155	COG0671	phosphoesterase, PA-phosphatase related
VAB18032_13180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_13190	COG4326	sporulation control protein
VAB18032_13205	COG3973	AAA domain
VAB18032_13345	COG2226	methyltransferase
VAB18032_13400	COG0024	Methionine aminopeptidase
VAB18032_13405	COG2814	Major facilitator Superfamily
VAB18032_13410	COG0831	urea catabolic process
VAB18032_13430	COG0830	nickel cation binding
VAB18032_13440	COG0829	nickel cation binding
VAB18032_13445	COG4413	Urea transporter
VAB18032_13455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VAB18032_13455	COG0456	acetyltransferase
VAB18032_13460	COG1278	Cold shock
VAB18032_13465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAB18032_13475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAB18032_13490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAB18032_13490	COG0425	Belongs to the sulfur carrier protein TusA family
VAB18032_13495	COG1937	Protein conserved in bacteria
VAB18032_13500	COG0456	acetyltransferase
VAB18032_13500	COG0454	-acetyltransferase
VAB18032_13505	COG0439	Biotin carboxylase
VAB18032_13515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAB18032_13530	COG3706	GGDEF domain
VAB18032_13535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAB18032_13540	COG0247	lactate metabolic process
VAB18032_13545	COG1139	Iron-sulfur cluster binding protein
VAB18032_13550	COG1556	Lactate utilization protein
VAB18032_13565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_13580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAB18032_13580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAB18032_13590	COG0586	Pfam SNARE associated Golgi protein
VAB18032_13615	COG3304	Inner membrane component domain
VAB18032_13650	COG1120	ATPase activity
VAB18032_13675	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VAB18032_13700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAB18032_13700	COG1017	nitric oxide dioxygenase activity
VAB18032_13705	COG1959	2 iron, 2 sulfur cluster binding
VAB18032_13715	COG0187	DNA topoisomerase II activity
VAB18032_13715	COG1372	Participates in initiation and elongation during chromosome replication
VAB18032_13720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VAB18032_13720	COG1372	Participates in initiation and elongation during chromosome replication
VAB18032_13730	COG2233	PERMEase
VAB18032_13745	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
VAB18032_13765	COG1086	Polysaccharide biosynthesis protein
VAB18032_13785	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_13795	COG2089	acid synthase
VAB18032_13800	COG1216	Glycosyl transferase, family 2
VAB18032_13840	COG1388	LysM domain
VAB18032_13840	COG1134	teichoic acid transport
VAB18032_13850	COG1309	transcriptional regulator
VAB18032_13865	COG0745	RESPONSE REGULATOR receiver
VAB18032_13870	COG0642	Histidine kinase
VAB18032_13885	COG3022	response to hydroperoxide
VAB18032_13900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAB18032_13905	COG0366	Alpha amylase catalytic
VAB18032_13915	COG1053	succinate dehydrogenase
VAB18032_13920	COG1902	pentaerythritol trinitrate reductase activity
VAB18032_13940	COG0297	glycogen (starch) synthase activity
VAB18032_13945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAB18032_13955	COG1086	Polysaccharide biosynthesis protein
VAB18032_13985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VAB18032_13990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAB18032_13995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAB18032_14005	COG2183	response to ionizing radiation
VAB18032_14010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAB18032_14035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAB18032_14040	COG1053	succinate dehydrogenase
VAB18032_14050	COG0583	DNA-binding transcription factor activity
VAB18032_14055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_14060	COG1643	Atp-dependent helicase
VAB18032_14090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAB18032_14110	COG0708	Exodeoxyribonuclease III
VAB18032_14135	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_14140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_14160	COG0596	Alpha beta hydrolase
VAB18032_14210	COG0667	Aldo Keto reductase
VAB18032_14215	COG0137	argininosuccinate synthase activity
VAB18032_14220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_14235	COG1741	Belongs to the pirin family
VAB18032_14260	COG1233	COG1233 Phytoene dehydrogenase and related
VAB18032_14310	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_14320	COG0463	Glycosyl transferase, family 2
VAB18032_14330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAB18032_14340	COG0297	glycogen (starch) synthase activity
VAB18032_14345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAB18032_14350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VAB18032_14350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VAB18032_14360	COG0859	PFAM glycosyl transferase family 9
VAB18032_14395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_14405	COG1472	Belongs to the glycosyl hydrolase 3 family
VAB18032_14445	COG1278	Cold shock
VAB18032_14455	COG0667	Aldo Keto reductase
VAB18032_14460	COG4106	trans-aconitate 2-methyltransferase activity
VAB18032_14465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAB18032_14495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VAB18032_14525	COG1560	Kdo2-lipid A biosynthetic process
VAB18032_14530	COG0438	transferase activity, transferring glycosyl groups
VAB18032_14540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
VAB18032_14545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
VAB18032_14560	COG0217	transcriptional regulatory protein
VAB18032_14615	COG4152	abc transporter atp-binding protein
VAB18032_14620	COG2197	response regulator
VAB18032_14625	COG4585	Histidine kinase
VAB18032_14630	COG0501	Belongs to the peptidase M48B family
VAB18032_14635	COG1704	LemA family
VAB18032_14650	COG1309	transcriptional regulator
VAB18032_14660	COG0587	DNA-directed DNA polymerase activity
VAB18032_14680	COG0477	Major facilitator Superfamily
VAB18032_14685	COG1309	transcriptional regulator
VAB18032_14690	COG0586	Pfam SNARE associated Golgi protein
VAB18032_14700	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_14705	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAB18032_14710	COG0632	four-way junction helicase activity
VAB18032_14715	COG2255	four-way junction helicase activity
VAB18032_14720	COG1862	Preprotein translocase
VAB18032_14730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAB18032_14735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VAB18032_14740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAB18032_14745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAB18032_14760	COG0124	histidyl-tRNA synthetase
VAB18032_14790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAB18032_14795	COG1091	dTDP-4-dehydrorhamnose reductase activity
VAB18032_14845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAB18032_14850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAB18032_14875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAB18032_14935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAB18032_14940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAB18032_14955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAB18032_14960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAB18032_14965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAB18032_14970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAB18032_14980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VAB18032_14985	COG0540	Belongs to the ATCase OTCase family
VAB18032_14990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VAB18032_14995	COG0505	Belongs to the CarA family
VAB18032_15005	COG0167	dihydroorotate dehydrogenase activity
VAB18032_15010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAB18032_15015	COG0284	orotidine-5'-phosphate decarboxylase activity
VAB18032_15025	COG0194	GDP metabolic process
VAB18032_15030	COG1758	RNA polymerase activity
VAB18032_15040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAB18032_15050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VAB18032_15055	COG2124	cytochrome p450
VAB18032_15060	COG0242	peptide deformylase activity
VAB18032_15065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAB18032_15090	COG0745	RESPONSE REGULATOR receiver
VAB18032_15110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAB18032_15110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAB18032_15115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAB18032_15130	COG0765	amino acid transport
VAB18032_15135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB18032_15140	COG0140	phosphoribosyl-ATP diphosphatase activity
VAB18032_15145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAB18032_15155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VAB18032_15160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VAB18032_15165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VAB18032_15170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAB18032_15175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAB18032_15180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAB18032_15180	COG0072	phenylalanine-tRNA ligase activity
VAB18032_15185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAB18032_15205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAB18032_15215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAB18032_15220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAB18032_15225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
VAB18032_15230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAB18032_15235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAB18032_15245	COG1438	arginine binding
VAB18032_15250	COG0165	Argininosuccinate lyase
VAB18032_15265	COG2094	Belongs to the DNA glycosylase MPG family
VAB18032_15270	COG3152	Membrane
VAB18032_15275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_15280	COG0431	NADPH-dependent FMN reductase
VAB18032_15295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VAB18032_15310	COG1253	flavin adenine dinucleotide binding
VAB18032_15325	COG1914	H( )-stimulated, divalent metal cation uptake system
VAB18032_15335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAB18032_15350	COG0647	UMP catabolic process
VAB18032_15375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAB18032_15405	COG0297	glycogen (starch) synthase activity
VAB18032_15415	COG0504	CTP synthase activity
VAB18032_15420	COG0494	nUDIX hydrolase
VAB18032_15445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
VAB18032_15450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VAB18032_15455	COG1187	pseudouridine synthase activity
VAB18032_15465	COG1160	GTP binding
VAB18032_15535	COG2801	Transposase and inactivated derivatives
VAB18032_15585	COG0542	response to heat
VAB18032_15655	COG3845	ABC transporter
VAB18032_15670	COG2079	MmgE PrpD family protein
VAB18032_15675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VAB18032_15685	COG1024	Enoyl-CoA hydratase
VAB18032_15780	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAB18032_15795	COG0641	radical SAM
VAB18032_15995	COG2801	Transposase and inactivated derivatives
VAB18032_16060	COG2801	Transposase and inactivated derivatives
VAB18032_16155	COG0076	glutamate decarboxylase activity
VAB18032_16185	COG0210	DNA helicase
VAB18032_16220	COG1518	maintenance of DNA repeat elements
VAB18032_16255	COG0395	ABC-type sugar transport system, permease component
VAB18032_16260	COG4209	transmembrane transport
VAB18032_16290	COG0492	ferredoxin-NADP+ reductase activity
VAB18032_16295	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_16310	COG1607	acyl-coa hydrolase
VAB18032_16315	COG1280	lysine exporter protein (LysE YggA)
VAB18032_16325	COG2201	protein-glutamate methylesterase activity
VAB18032_16330	COG2175	clavaminate synthase activity
VAB18032_16345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_16355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAB18032_16375	COG0431	NADPH-dependent FMN reductase
VAB18032_16385	COG2124	cytochrome p450
VAB18032_16390	COG4172	Belongs to the ABC transporter superfamily
VAB18032_16405	COG0747	negative chemotaxis
VAB18032_16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_16415	COG2814	Major facilitator Superfamily
VAB18032_16460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAB18032_16490	COG3629	intracellular signal transduction
VAB18032_16505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAB18032_16530	COG4948	Mandelate Racemase Muconate Lactonizing
VAB18032_16535	COG1879	ABC-type sugar transport system periplasmic component
VAB18032_16540	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_16545	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_16550	COG1129	ABC transporter
VAB18032_16555	COG2376	Dihydroxyacetone kinase
VAB18032_16560	COG1461	Dihydroxyacetone kinase
VAB18032_16570	COG2186	Transcriptional regulator
VAB18032_16585	COG0693	protein deglycase activity
VAB18032_16595	COG0252	asparaginase activity
VAB18032_16610	COG0577	efflux transmembrane transporter activity
VAB18032_16610	COG1136	(ABC) transporter
VAB18032_16615	COG1136	(ABC) transporter
VAB18032_16640	COG0254	rRNA binding
VAB18032_16650	COG0745	RESPONSE REGULATOR receiver
VAB18032_16655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAB18032_16660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAB18032_16665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAB18032_16685	COG0803	Belongs to the bacterial solute-binding protein 9 family
VAB18032_16695	COG1121	(ABC) transporter
VAB18032_16700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VAB18032_16725	COG2801	Transposase and inactivated derivatives
VAB18032_16835	COG1733	regulation of RNA biosynthetic process
VAB18032_16840	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_16840	COG3321	synthase
VAB18032_16840	COG0604	alcohol dehydrogenase
VAB18032_16850	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_16935	COG0667	Aldo Keto reductase
VAB18032_16970	COG0604	alcohol dehydrogenase
VAB18032_16970	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_16970	COG3321	synthase
VAB18032_16975	COG1309	transcriptional regulator
VAB18032_17010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VAB18032_17025	COG0477	Major facilitator Superfamily
VAB18032_17030	COG2084	Dehydrogenase
VAB18032_17040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAB18032_17045	COG2124	cytochrome p450
VAB18032_17080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAB18032_17085	COG4319	ketosteroid isomerase
VAB18032_17100	COG3321	synthase
VAB18032_17100	COG0604	alcohol dehydrogenase
VAB18032_17145	COG2197	response regulator
VAB18032_17175	COG1253	flavin adenine dinucleotide binding
VAB18032_17315	COG2226	methyltransferase
VAB18032_17350	COG0679	Auxin Efflux Carrier
VAB18032_17360	COG1595	DNA-templated transcription, initiation
VAB18032_17420	COG1454	alcohol dehydrogenase
VAB18032_17430	COG3842	ATPase activity
VAB18032_17445	COG1175	transmembrane transport
VAB18032_17460	COG0693	protein deglycase activity
VAB18032_17475	COG1309	transcriptional regulator
VAB18032_17480	COG1131	(ABC) transporter
VAB18032_17485	COG3559	Exporter of polyketide antibiotics
VAB18032_17500	COG2815	serine threonine protein kinase
VAB18032_17500	COG0515	serine threonine protein kinase
VAB18032_17510	COG1063	alcohol dehydrogenase
VAB18032_17535	COG0673	inositol 2-dehydrogenase activity
VAB18032_17540	COG2197	response regulator
VAB18032_17600	COG1278	Cold shock
VAB18032_17610	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_17615	COG3387	PFAM Glycoside hydrolase 15-related
VAB18032_17630	COG1960	acyl-CoA dehydrogenase activity
VAB18032_17635	COG1960	acyl-CoA dehydrogenase activity
VAB18032_17645	COG0410	ABC transporter
VAB18032_17650	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAB18032_17665	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_17675	COG1960	acyl-CoA dehydrogenase activity
VAB18032_17705	COG2197	response regulator
VAB18032_17745	COG1960	acyl-CoA dehydrogenase activity
VAB18032_17750	COG1960	acyl-CoA dehydrogenase activity
VAB18032_17765	COG0488	(ABC) transporter
VAB18032_17785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAB18032_17790	COG4569	acetaldehyde dehydrogenase (acetylating) activity
VAB18032_17795	COG3971	2-oxopent-4-enoate hydratase activity
VAB18032_17810	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
VAB18032_17835	COG1414	Transcriptional regulator
VAB18032_17840	COG0028	Belongs to the TPP enzyme family
VAB18032_17855	COG0318	PFAM AMP-dependent synthetase and ligase
VAB18032_17865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_17900	COG0515	serine threonine protein kinase
VAB18032_17935	COG0714	Associated with various cellular activities
VAB18032_17940	COG3552	Protein containing von Willebrand factor type A (VWA) domain
VAB18032_17990	COG2746	aminoglycoside 3-N-acetyltransferase activity
VAB18032_18005	COG0531	amino acid
VAB18032_18015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VAB18032_18020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAB18032_18050	COG0439	Biotin carboxylase
VAB18032_18055	COG0511	ligase activity, forming carbon-carbon bonds
VAB18032_18070	COG2867	negative regulation of translational initiation
VAB18032_18075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAB18032_18085	COG0367	asparagine synthase
VAB18032_18095	COG1136	(ABC) transporter
VAB18032_18095	COG0577	efflux transmembrane transporter activity
VAB18032_18110	COG1271	oxidase subunit
VAB18032_18115	COG4585	Histidine kinase
VAB18032_18120	COG2197	response regulator
VAB18032_18130	COG2345	Transcriptional regulator
VAB18032_18155	COG2197	response regulator
VAB18032_18160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAB18032_18160	COG0825	malonyl-CoA metabolic process
VAB18032_18170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAB18032_18175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAB18032_18190	COG3693	PFAM glycoside hydrolase, family 10
VAB18032_18195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAB18032_18205	COG1473	amidohydrolase
VAB18032_18210	COG0673	inositol 2-dehydrogenase activity
VAB18032_18215	COG1653	transport
VAB18032_18220	COG1175	transmembrane transport
VAB18032_18225	COG0395	ABC-type sugar transport system, permease component
VAB18032_18230	COG3254	rhamnose metabolic process
VAB18032_18235	COG4948	Mandelate Racemase Muconate Lactonizing
VAB18032_18240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VAB18032_18250	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_18290	COG0395	ABC-type sugar transport system, permease component
VAB18032_18295	COG4948	Mandelate Racemase Muconate Lactonizing
VAB18032_18315	COG1129	ABC transporter
VAB18032_18320	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_18325	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_18330	COG4213	ABC transporter substrate-binding protein
VAB18032_18345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_18360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAB18032_18365	COG3693	PFAM glycoside hydrolase, family 10
VAB18032_18390	COG1733	regulation of RNA biosynthetic process
VAB18032_18400	COG2207	Transcriptional regulator
VAB18032_18400	COG1609	Transcriptional regulator
VAB18032_18465	COG2124	cytochrome p450
VAB18032_18470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_18510	COG1404	Belongs to the peptidase S8 family
VAB18032_18595	COG0477	Major facilitator Superfamily
VAB18032_18615	COG1609	Transcriptional regulator
VAB18032_18635	COG0395	ABC-type sugar transport system, permease component
VAB18032_18650	COG3507	Belongs to the glycosyl hydrolase 43 family
VAB18032_18680	COG0697	spore germination
VAB18032_18685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAB18032_18695	COG1131	(ABC) transporter
VAB18032_18710	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VAB18032_18720	COG0018	arginyl-trna synthetase
VAB18032_18740	COG0475	glutathione-regulated potassium exporter activity
VAB18032_18750	COG1070	Carbohydrate kinase
VAB18032_18755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAB18032_18790	COG1131	(ABC) transporter
VAB18032_18795	COG4585	Histidine kinase
VAB18032_18805	COG1960	acyl-CoA dehydrogenase activity
VAB18032_18835	COG1132	(ABC) transporter
VAB18032_18850	COG2936	dipeptidyl-peptidase activity
VAB18032_18860	COG3903	Transcriptional regulator
VAB18032_18860	COG3629	intracellular signal transduction
VAB18032_18885	COG0442	prolyl-tRNA aminoacylation
VAB18032_18910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VAB18032_18915	COG3507	Belongs to the glycosyl hydrolase 43 family
VAB18032_18925	COG0235	Class ii aldolase
VAB18032_18940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_18965	COG0640	Transcriptional regulator
VAB18032_19005	COG0318	PFAM AMP-dependent synthetase and ligase
VAB18032_19010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_19030	COG0640	Transcriptional regulator
VAB18032_19035	COG0798	PFAM Bile acid sodium symporter
VAB18032_19040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAB18032_19070	COG3507	Belongs to the glycosyl hydrolase 43 family
VAB18032_19080	COG0747	negative chemotaxis
VAB18032_19085	COG0601	transmembrane transport
VAB18032_19095	COG0444	Belongs to the ABC transporter superfamily
VAB18032_19105	COG1228	amidohydrolase
VAB18032_19140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAB18032_19145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAB18032_19200	COG0346	lactoylglutathione lyase activity
VAB18032_19210	COG5398	heme oxygenase
VAB18032_19220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAB18032_19225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB18032_19230	COG4558	Periplasmic binding protein
VAB18032_19255	COG0010	Belongs to the arginase family
VAB18032_19270	COG0604	alcohol dehydrogenase
VAB18032_19270	COG3321	synthase
VAB18032_19275	COG0640	Transcriptional regulator
VAB18032_19290	COG2124	cytochrome p450
VAB18032_19300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_19305	COG2814	Major facilitator Superfamily
VAB18032_19340	COG2814	Major facilitator Superfamily
VAB18032_19350	COG0739	heme binding
VAB18032_19355	COG0747	negative chemotaxis
VAB18032_19360	COG0601	transmembrane transport
VAB18032_19370	COG0444	Belongs to the ABC transporter superfamily
VAB18032_19375	COG4608	Belongs to the ABC transporter superfamily
VAB18032_19380	COG1959	2 iron, 2 sulfur cluster binding
VAB18032_19390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
VAB18032_19395	COG4208	sulfate ABC transporter
VAB18032_19400	COG3842	ATPase activity
VAB18032_19420	COG1609	Transcriptional regulator
VAB18032_19430	COG1175	transmembrane transport
VAB18032_19435	COG0395	ABC-type sugar transport system, permease component
VAB18032_19455	COG1129	ABC transporter
VAB18032_19460	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_19465	COG4948	Mandelate Racemase Muconate Lactonizing
VAB18032_19480	COG1063	alcohol dehydrogenase
VAB18032_19485	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_19520	COG4214	carbohydrate transport
VAB18032_19530	COG3345	alpha-galactosidase
VAB18032_19550	COG1879	ABC-type sugar transport system periplasmic component
VAB18032_19560	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_19565	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_19570	COG2160	L-arabinose isomerase activity
VAB18032_19615	COG0456	acetyltransferase
VAB18032_19615	COG1846	Transcriptional regulator
VAB18032_19620	COG1960	acyl-CoA dehydrogenase activity
VAB18032_19650	COG4221	oxidoreductase activity
VAB18032_19655	COG3509	depolymerase
VAB18032_19665	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAB18032_19705	COG1414	Transcriptional regulator
VAB18032_19715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
VAB18032_19720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VAB18032_19725	COG3485	protocatechuate 3,4-dioxygenase
VAB18032_19730	COG3485	protocatechuate 3,4-dioxygenase
VAB18032_19735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAB18032_19740	COG2267	carboxylic ester hydrolase activity
VAB18032_19745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAB18032_19750	COG1414	Transcriptional regulator
VAB18032_19795	COG0583	DNA-binding transcription factor activity
VAB18032_19815	COG0789	Transcriptional regulator
VAB18032_19820	COG0667	Aldo Keto reductase
VAB18032_19845	COG0704	Plays a role in the regulation of phosphate uptake
VAB18032_19850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAB18032_19855	COG0573	inorganic phosphate transmembrane transporter activity
VAB18032_19865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAB18032_19870	COG0745	RESPONSE REGULATOR receiver
VAB18032_19890	COG5001	Diguanylate cyclase
VAB18032_19905	COG1609	Transcriptional regulator
VAB18032_19915	COG2815	serine threonine protein kinase
VAB18032_19915	COG0515	serine threonine protein kinase
VAB18032_19925	COG0586	Pfam SNARE associated Golgi protein
VAB18032_19940	COG1686	Belongs to the peptidase S11 family
VAB18032_19965	COG2111	Na H antiporter
VAB18032_19965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAB18032_19985	COG2212	antiporter activity
VAB18032_19995	COG1690	Belongs to the RtcB family
VAB18032_20005	COG2197	response regulator
VAB18032_20010	COG4585	Histidine kinase
VAB18032_20025	COG2197	response regulator
VAB18032_20030	COG4585	Histidine kinase
VAB18032_20040	COG1131	(ABC) transporter
VAB18032_20060	COG1132	(ABC) transporter
VAB18032_20065	COG1132	(ABC) transporter
VAB18032_20095	COG1136	(ABC) transporter
VAB18032_20115	COG5002	protein histidine kinase activity
VAB18032_20120	COG0745	RESPONSE REGULATOR receiver
VAB18032_20165	COG0438	transferase activity, transferring glycosyl groups
VAB18032_20180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAB18032_20185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAB18032_20185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAB18032_20230	COG1120	ATPase activity
VAB18032_20235	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB18032_20240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB18032_20255	COG3486	L-lysine 6-monooxygenase (NADPH) activity
VAB18032_20295	COG2226	methyltransferase
VAB18032_20300	COG0673	inositol 2-dehydrogenase activity
VAB18032_20315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAB18032_20335	COG1960	acyl-CoA dehydrogenase activity
VAB18032_20365	COG1509	lysine 2,3-aminomutase activity
VAB18032_20370	COG0604	alcohol dehydrogenase
VAB18032_20375	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VAB18032_20380	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAB18032_20385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VAB18032_20390	COG1607	acyl-coa hydrolase
VAB18032_20405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAB18032_20415	COG1216	Glycosyl transferase, family 2
VAB18032_20435	COG1609	Transcriptional regulator
VAB18032_20445	COG1940	carbohydrate kinase activity
VAB18032_20455	COG1280	lysine exporter protein (LysE YggA)
VAB18032_20515	COG0071	Belongs to the small heat shock protein (HSP20) family
VAB18032_20520	COG4974	Belongs to the 'phage' integrase family
VAB18032_20530	COG1136	(ABC) transporter
VAB18032_20535	COG1136	(ABC) transporter
VAB18032_20550	COG1435	thymidine kinase activity
VAB18032_20555	COG2270	Major facilitator Superfamily
VAB18032_20565	COG4989	oxidoreductase activity
VAB18032_20570	COG0204	Acyl-transferase
VAB18032_20575	COG1271	oxidase subunit
VAB18032_20580	COG1294	oxidase, subunit
VAB18032_20600	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_20620	COG1335	isochorismatase
VAB18032_20630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_20645	COG1012	belongs to the aldehyde dehydrogenase family
VAB18032_20655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAB18032_20670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VAB18032_20690	COG2267	carboxylic ester hydrolase activity
VAB18032_20705	COG1802	Transcriptional regulator
VAB18032_20755	COG0242	peptide deformylase activity
VAB18032_20770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAB18032_20770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAB18032_20775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAB18032_20785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAB18032_20785	COG1017	nitric oxide dioxygenase activity
VAB18032_20890	COG1921	L-seryl-tRNASec selenium transferase activity
VAB18032_20900	COG0437	4 iron, 4 sulfur cluster binding
VAB18032_20905	COG3383	formate dehydrogenase (NAD+) activity
VAB18032_20905	COG0243	molybdopterin cofactor binding
VAB18032_20910	COG0243	molybdopterin cofactor binding
VAB18032_20910	COG3383	formate dehydrogenase (NAD+) activity
VAB18032_20930	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_20935	COG0644	oxidoreductase
VAB18032_20960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAB18032_20995	COG3384	dioxygenase
VAB18032_21000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VAB18032_21010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_21030	COG1357	PFAM Pentapeptide repeats (8 copies)
VAB18032_21035	COG0328	RNA-DNA hybrid ribonuclease activity
VAB18032_21065	COG3012	SEC-C Motif Domain Protein
VAB18032_21090	COG0069	glutamate synthase activity
VAB18032_21095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAB18032_21160	COG1131	(ABC) transporter
VAB18032_21175	COG3265	gluconokinase activity
VAB18032_21180	COG4948	Mandelate Racemase Muconate Lactonizing
VAB18032_21190	COG0800	Aldolase
VAB18032_21195	COG4948	Mandelate Racemase Muconate Lactonizing
VAB18032_21200	COG0395	ABC-type sugar transport system, permease component
VAB18032_21205	COG1175	transmembrane transport
VAB18032_21215	COG1802	Transcriptional regulator
VAB18032_21235	COG1595	DNA-templated transcription, initiation
VAB18032_21240	COG0702	epimerase
VAB18032_21305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAB18032_21360	COG2197	response regulator
VAB18032_21410	COG1233	COG1233 Phytoene dehydrogenase and related
VAB18032_21420	COG2814	Major facilitator Superfamily
VAB18032_21425	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
VAB18032_21450	COG0789	Transcriptional regulator
VAB18032_21460	COG0515	serine threonine protein kinase
VAB18032_21460	COG2815	serine threonine protein kinase
VAB18032_21515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAB18032_21520	COG0515	serine threonine protein kinase
VAB18032_21520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAB18032_21535	COG0328	RNA-DNA hybrid ribonuclease activity
VAB18032_21565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_21570	COG1846	Transcriptional regulator
VAB18032_21590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAB18032_21595	COG1063	alcohol dehydrogenase
VAB18032_21610	COG1175	transmembrane transport
VAB18032_21675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAB18032_21765	COG2318	DinB family
VAB18032_21810	COG4106	trans-aconitate 2-methyltransferase activity
VAB18032_21825	COG3483	tryptophan 2,3-dioxygenase activity
VAB18032_21835	COG0714	Associated with various cellular activities
VAB18032_21860	COG0789	Transcriptional regulator
VAB18032_21880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VAB18032_21890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
VAB18032_21970	COG1725	Transcriptional regulator
VAB18032_21985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAB18032_22025	COG2207	Transcriptional regulator
VAB18032_22030	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_22045	COG1132	(ABC) transporter
VAB18032_22060	COG1733	regulation of RNA biosynthetic process
VAB18032_22075	COG2855	membrane
VAB18032_22085	COG3629	intracellular signal transduction
VAB18032_22085	COG3903	Transcriptional regulator
VAB18032_22115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
VAB18032_22125	COG3251	PFAM MbtH domain protein
VAB18032_22145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAB18032_22155	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAB18032_22160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAB18032_22180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAB18032_22190	COG0165	Argininosuccinate lyase
VAB18032_22220	COG0300	oxidoreductase activity
VAB18032_22220	COG3321	synthase
VAB18032_22220	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_22220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_22220	COG0318	PFAM AMP-dependent synthetase and ligase
VAB18032_22255	COG0028	Belongs to the TPP enzyme family
VAB18032_22260	COG0277	FAD linked oxidase domain protein
VAB18032_22265	COG0436	Aminotransferase
VAB18032_22275	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_22305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_22310	COG0475	glutathione-regulated potassium exporter activity
VAB18032_22340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
VAB18032_22340	COG2508	Transcriptional regulator
VAB18032_22355	COG3842	ATPase activity
VAB18032_22375	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VAB18032_22420	COG0326	Molecular chaperone. Has ATPase activity
VAB18032_22435	COG5002	protein histidine kinase activity
VAB18032_22440	COG0745	RESPONSE REGULATOR receiver
VAB18032_22505	COG0683	leucine binding
VAB18032_22520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
VAB18032_22530	COG0829	nickel cation binding
VAB18032_22535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VAB18032_22540	COG0830	nickel cation binding
VAB18032_22550	COG0832	Belongs to the urease beta subunit family
VAB18032_22555	COG0831	urea catabolic process
VAB18032_22560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB18032_22565	COG0765	amino acid transport
VAB18032_22570	COG1126	abc transporter atp-binding protein
VAB18032_22585	COG3559	Exporter of polyketide antibiotics
VAB18032_22590	COG1131	(ABC) transporter
VAB18032_22595	COG1309	transcriptional regulator
VAB18032_22605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VAB18032_22635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_22640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAB18032_22645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAB18032_22650	COG1116	anion transmembrane transporter activity
VAB18032_22655	COG2855	membrane
VAB18032_22670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAB18032_22710	COG0515	serine threonine protein kinase
VAB18032_22720	COG1132	(ABC) transporter
VAB18032_22725	COG1132	(ABC) transporter
VAB18032_22735	COG2197	response regulator
VAB18032_22740	COG2197	response regulator
VAB18032_22745	COG0805	protein transport
VAB18032_22750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAB18032_22760	COG2378	regulation of single-species biofilm formation
VAB18032_22780	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VAB18032_22825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VAB18032_22830	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VAB18032_22840	COG4122	O-methyltransferase activity
VAB18032_22850	COG1222	aaa ATPase
VAB18032_22855	COG1141	Ferredoxin
VAB18032_22870	COG0517	IMP dehydrogenase activity
VAB18032_22870	COG1994	Peptidase M50
VAB18032_22880	COG4585	Histidine kinase
VAB18032_22885	COG2197	response regulator
VAB18032_22890	COG1136	(ABC) transporter
VAB18032_22890	COG0577	efflux transmembrane transporter activity
VAB18032_22895	COG0577	efflux transmembrane transporter activity
VAB18032_22895	COG1136	(ABC) transporter
VAB18032_22900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB18032_22910	COG0387	Pfam Sodium calcium exchanger
VAB18032_22925	COG4974	Belongs to the 'phage' integrase family
VAB18032_22930	COG1410	methionine synthase
VAB18032_22930	COG0646	methionine synthase
VAB18032_22945	COG0215	cysteine-tRNA ligase activity
VAB18032_22970	COG1968	undecaprenyl-diphosphatase activity
VAB18032_22975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_22980	COG0667	Aldo Keto reductase
VAB18032_23000	COG2140	Oxalate decarboxylase
VAB18032_23020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAB18032_23050	COG0542	response to heat
VAB18032_23070	COG1674	ftsk spoiiie
VAB18032_23095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VAB18032_23110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VAB18032_23120	COG0745	RESPONSE REGULATOR receiver
VAB18032_23125	COG0745	RESPONSE REGULATOR receiver
VAB18032_23160	COG0653	protein targeting
VAB18032_23165	COG0463	Glycosyl transferase, family 2
VAB18032_23175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAB18032_23190	COG0028	Belongs to the TPP enzyme family
VAB18032_23205	COG2409	Drug exporters of the RND superfamily
VAB18032_23225	COG2367	Beta-lactamase
VAB18032_23260	COG1476	TRANSCRIPTIONal
VAB18032_23270	COG0137	argininosuccinate synthase activity
VAB18032_23285	COG0483	inositol monophosphate 1-phosphatase activity
VAB18032_23345	COG0745	RESPONSE REGULATOR receiver
VAB18032_23390	COG2205	protein histidine kinase activity
VAB18032_23395	COG0745	RESPONSE REGULATOR receiver
VAB18032_23405	COG2815	serine threonine protein kinase
VAB18032_23405	COG0515	serine threonine protein kinase
VAB18032_23420	COG0784	Response regulator, receiver
VAB18032_23440	COG1366	Belongs to the anti-sigma-factor antagonist family
VAB18032_23445	COG1366	Belongs to the anti-sigma-factor antagonist family
VAB18032_23470	COG0543	2 iron, 2 sulfur cluster binding
VAB18032_23470	COG0633	Ferredoxin
VAB18032_23475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VAB18032_23485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAB18032_23535	COG0489	protein tyrosine kinase activity
VAB18032_23540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAB18032_23550	COG2119	membrane
VAB18032_23555	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
VAB18032_23560	COG0121	glutamine amidotransferase
VAB18032_23565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAB18032_23585	COG0515	serine threonine protein kinase
VAB18032_23600	COG1136	(ABC) transporter
VAB18032_23600	COG0577	efflux transmembrane transporter activity
VAB18032_23605	COG2197	response regulator
VAB18032_23610	COG4585	Histidine kinase
VAB18032_23640	COG0367	asparagine synthase
VAB18032_23655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAB18032_23690	COG1376	ErfK ybiS ycfS ynhG family protein
VAB18032_23730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAB18032_23740	COG3973	AAA domain
VAB18032_23775	COG3629	intracellular signal transduction
VAB18032_23775	COG3903	Transcriptional regulator
VAB18032_23825	COG1672	PFAM Archaeal ATPase
VAB18032_23825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAB18032_23830	COG2226	methyltransferase
VAB18032_23835	COG0738	Major facilitator superfamily
VAB18032_23935	COG0706	membrane insertase activity
VAB18032_23950	COG1175	transmembrane transport
VAB18032_23960	COG1609	Transcriptional regulator
VAB18032_24000	COG0395	ABC-type sugar transport system, permease component
VAB18032_24005	COG1175	transmembrane transport
VAB18032_24020	COG0673	inositol 2-dehydrogenase activity
VAB18032_24025	COG1904	glucuronate isomerase
VAB18032_24030	COG4948	Mandelate Racemase Muconate Lactonizing
VAB18032_24035	COG0246	Mannitol dehydrogenase
VAB18032_24045	COG3866	Pectate lyase
VAB18032_24050	COG3866	Pectate lyase
VAB18032_24060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAB18032_24090	COG4608	Belongs to the ABC transporter superfamily
VAB18032_24100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAB18032_24105	COG0601	transmembrane transport
VAB18032_24115	COG4326	sporulation control protein
VAB18032_24120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAB18032_24150	COG3509	depolymerase
VAB18032_24175	COG3458	cephalosporin-C deacetylase activity
VAB18032_24185	COG4209	transmembrane transport
VAB18032_24190	COG0395	ABC-type sugar transport system, permease component
VAB18032_24195	COG1653	transport
VAB18032_24290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VAB18032_24305	COG4585	Histidine kinase
VAB18032_24330	COG3507	Belongs to the glycosyl hydrolase 43 family
VAB18032_24335	COG3507	Belongs to the glycosyl hydrolase 43 family
VAB18032_24360	COG1704	LemA family
VAB18032_24385	COG0009	L-threonylcarbamoyladenylate synthase
VAB18032_24390	COG4260	virion core protein, lumpy skin disease virus
VAB18032_24435	COG1132	(ABC) transporter
VAB18032_24450	COG2353	YceI-like domain
VAB18032_24455	COG1414	Transcriptional regulator
VAB18032_24460	COG0800	Aldolase
VAB18032_24465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAB18032_24490	COG2207	Transcriptional regulator
VAB18032_24510	COG0778	Nitroreductase
VAB18032_24515	COG0492	ferredoxin-NADP+ reductase activity
VAB18032_24535	COG0513	Belongs to the DEAD box helicase family
VAB18032_24555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAB18032_24555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAB18032_24560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAB18032_24560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAB18032_24610	COG4585	Histidine kinase
VAB18032_24620	COG1136	(ABC) transporter
VAB18032_24620	COG0577	efflux transmembrane transporter activity
VAB18032_24635	COG1063	alcohol dehydrogenase
VAB18032_24640	COG0596	Alpha beta hydrolase
VAB18032_24655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAB18032_24705	COG0596	Alpha beta hydrolase
VAB18032_24730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAB18032_24740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAB18032_24750	COG2267	carboxylic ester hydrolase activity
VAB18032_24770	COG0596	Alpha beta hydrolase
VAB18032_24810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAB18032_24810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAB18032_24815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VAB18032_24860	COG1917	Cupin 2, conserved barrel domain protein
VAB18032_24860	COG4977	sequence-specific DNA binding
VAB18032_24880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAB18032_24885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAB18032_24890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_24910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB18032_24920	COG3251	PFAM MbtH domain protein
VAB18032_24925	COG0017	Asparaginyl-tRNA synthetase
VAB18032_24930	COG0069	glutamate synthase activity
VAB18032_24935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAB18032_24990	COG3903	Transcriptional regulator
VAB18032_24990	COG3629	intracellular signal transduction
VAB18032_25050	COG0714	Associated with various cellular activities
VAB18032_25085	COG5297	Belongs to the glycosyl hydrolase family 6
VAB18032_25085	COG4733	cellulase activity
VAB18032_25115	COG2018	Roadblock/LC7 domain
VAB18032_25135	COG0655	NAD(P)H dehydrogenase (quinone) activity
VAB18032_25145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB18032_25155	COG0697	spore germination
VAB18032_25160	COG1620	l-lactate permease
VAB18032_25230	COG2936	dipeptidyl-peptidase activity
VAB18032_25300	COG2226	methyltransferase
VAB18032_25305	COG0494	nUDIX hydrolase
VAB18032_25315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAB18032_25325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VAB18032_25360	COG1988	membrane-bound metal-dependent
VAB18032_25370	COG1501	Belongs to the glycosyl hydrolase 31 family
VAB18032_25405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAB18032_25405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAB18032_25430	COG0395	ABC-type sugar transport system, permease component
VAB18032_25445	COG4821	SIS domain
VAB18032_25470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAB18032_25490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAB18032_25495	COG1365	unkown
VAB18032_25505	COG1733	regulation of RNA biosynthetic process
VAB18032_25520	COG5297	Belongs to the glycosyl hydrolase family 6
VAB18032_25520	COG4733	cellulase activity
VAB18032_25530	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
VAB18032_25535	COG0583	DNA-binding transcription factor activity
VAB18032_25555	COG1252	NADH dehydrogenase
VAB18032_25560	COG1595	DNA-templated transcription, initiation
VAB18032_25575	COG0028	Belongs to the TPP enzyme family
VAB18032_25625	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_25645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAB18032_25670	COG0714	Associated with various cellular activities
VAB18032_25720	COG0006	proline dipeptidase activity
VAB18032_25780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VAB18032_25795	COG2018	Roadblock/LC7 domain
VAB18032_25835	COG1309	transcriptional regulator
VAB18032_25845	COG3220	belongs to the UPF0276 family
VAB18032_25855	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_25860	COG3663	DNA glycosylase
VAB18032_25865	COG1132	(ABC) transporter
VAB18032_25880	COG0488	(ABC) transporter
VAB18032_25885	COG2321	neutral zinc metallopeptidase
VAB18032_25915	COG0822	iron-sulfur transferase activity
VAB18032_25920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAB18032_25925	COG0396	ATPase activity
VAB18032_25930	COG2146	nitrite reductase [NAD(P)H] activity
VAB18032_25965	COG0109	protoheme IX farnesyltransferase activity
VAB18032_25975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAB18032_25980	COG0166	Belongs to the GPI family
VAB18032_25995	COG0363	glucosamine-6-phosphate deaminase activity
VAB18032_26005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAB18032_26010	COG0149	triose-phosphate isomerase activity
VAB18032_26015	COG0126	phosphoglycerate kinase activity
VAB18032_26020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAB18032_26025	COG1481	regulation of sporulation
VAB18032_26035	COG1660	Displays ATPase and GTPase activities
VAB18032_26080	COG0322	excinuclease ABC activity
VAB18032_26100	COG1162	GTPase activity
VAB18032_26120	COG1278	Cold shock
VAB18032_26135	COG1846	Transcriptional regulator
VAB18032_26140	COG2409	Drug exporters of the RND superfamily
VAB18032_26145	COG0741	lytic transglycosylase activity
VAB18032_26150	COG0586	Pfam SNARE associated Golgi protein
VAB18032_26165	COG0861	Integral membrane protein TerC family
VAB18032_26170	COG2329	Antibiotic biosynthesis monooxygenase
VAB18032_26190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VAB18032_26190	COG0237	dephospho-CoA kinase activity
VAB18032_26195	COG0539	negative regulation of cytoplasmic translation
VAB18032_26225	COG0789	Transcriptional regulator
VAB18032_26235	COG1126	abc transporter atp-binding protein
VAB18032_26240	COG0765	amino acid transport
VAB18032_26245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB18032_26290	COG0626	cystathionine gamma-synthase activity
VAB18032_26300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAB18032_26305	COG3401	FG-GAP repeat protein
VAB18032_26315	COG0730	response to heat
VAB18032_26325	COG1946	Acyl-CoA thioesterase
VAB18032_26340	COG0667	Aldo Keto reductase
VAB18032_26350	COG0861	Integral membrane protein TerC family
VAB18032_26355	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_26546	COG2755	lipolytic protein G-D-S-L family
VAB18032_26556	COG0067	glutamate synthase
VAB18032_26556	COG0069	glutamate synthase activity
VAB18032_26556	COG0070	glutamate synthase
VAB18032_26571	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VAB18032_26576	COG0159	tryptophan synthase activity
VAB18032_26581	COG0133	tryptophan synthase activity
VAB18032_26601	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAB18032_26616	COG1131	(ABC) transporter
VAB18032_26631	COG1132	(ABC) transporter
VAB18032_26636	COG1132	(ABC) transporter
VAB18032_26646	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAB18032_26651	COG1022	Amp-dependent synthetase and ligase
VAB18032_26666	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAB18032_26681	COG0107	imidazoleglycerol-phosphate synthase activity
VAB18032_26686	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAB18032_26696	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VAB18032_26706	COG0131	Imidazoleglycerol-phosphate dehydratase
VAB18032_26711	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAB18032_26716	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VAB18032_26721	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAB18032_26746	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAB18032_26751	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VAB18032_26766	COG3599	regulation of cell shape
VAB18032_26776	COG1799	cell septum assembly
VAB18032_26786	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VAB18032_26791	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAB18032_26796	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAB18032_26801	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAB18032_26811	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAB18032_26821	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAB18032_26826	COG0768	penicillin binding
VAB18032_26836	COG0275	rRNA processing
VAB18032_26841	COG2001	Belongs to the MraZ family
VAB18032_26851	COG3442	glutamine amidotransferase
VAB18032_26871	COG0495	leucyl-tRNA aminoacylation
VAB18032_26876	COG0714	Associated with various cellular activities
VAB18032_26896	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAB18032_26906	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAB18032_26911	COG0587	DNA-directed DNA polymerase activity
VAB18032_26981	COG2815	serine threonine protein kinase
VAB18032_26981	COG0515	serine threonine protein kinase
VAB18032_26986	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VAB18032_26996	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
VAB18032_27011	COG0386	Belongs to the glutathione peroxidase family
VAB18032_27086	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VAB18032_27096	COG2072	flavoprotein involved in K transport
VAB18032_27106	COG1940	carbohydrate kinase activity
VAB18032_27131	COG2197	response regulator
VAB18032_27166	COG0438	transferase activity, transferring glycosyl groups
VAB18032_27171	COG0501	Belongs to the peptidase M48B family
VAB18032_27186	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAB18032_27196	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VAB18032_27211	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAB18032_27221	COG2010	Cytochrome c
VAB18032_27241	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAB18032_27256	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAB18032_27291	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAB18032_27296	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAB18032_27311	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
VAB18032_27316	COG1396	sequence-specific DNA binding
VAB18032_27341	COG0667	Aldo Keto reductase
VAB18032_27346	COG1994	Peptidase M50
VAB18032_27361	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAB18032_27366	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAB18032_27376	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAB18032_27381	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAB18032_27391	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAB18032_27396	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAB18032_27431	COG0321	lipoyl(octanoyl) transferase activity
VAB18032_27436	COG0017	Asparaginyl-tRNA synthetase
VAB18032_27441	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAB18032_27496	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAB18032_27501	COG0519	Catalyzes the synthesis of GMP from XMP
VAB18032_27501	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAB18032_27506	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAB18032_27516	COG3766	membrane
VAB18032_27521	COG0174	glutamine synthetase
VAB18032_27526	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAB18032_27526	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAB18032_27531	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VAB18032_27546	COG0557	exoribonuclease II activity
VAB18032_27556	COG1051	belongs to the nudix hydrolase family
VAB18032_27566	COG2207	Transcriptional regulator
VAB18032_27566	COG3708	Transcriptional regulator
VAB18032_27606	COG0730	response to heat
VAB18032_27611	COG0328	RNA-DNA hybrid ribonuclease activity
VAB18032_27611	COG0406	alpha-ribazole phosphatase activity
VAB18032_27621	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAB18032_27646	COG4279	zinc finger
VAB18032_27651	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAB18032_27661	COG2318	DinB family
VAB18032_27721	COG0022	dehydrogenase e1 component
VAB18032_27726	COG0432	Pfam Uncharacterised protein family UPF0047
VAB18032_27731	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAB18032_27756	COG2814	Major facilitator Superfamily
VAB18032_27761	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAB18032_27786	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAB18032_27791	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAB18032_27796	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAB18032_27821	COG2267	carboxylic ester hydrolase activity
VAB18032_27826	COG3973	AAA domain
VAB18032_27836	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VAB18032_27836	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VAB18032_27866	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAB18032_27866	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAB18032_27881	COG3268	Saccharopine dehydrogenase
VAB18032_27886	COG4978	Transcriptional regulator
VAB18032_27886	COG0789	Transcriptional regulator
VAB18032_27891	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VAB18032_27936	COG0277	FAD linked oxidase domain protein
VAB18032_27961	COG1131	(ABC) transporter
VAB18032_27986	COG4941	Belongs to the sigma-70 factor family
VAB18032_28011	COG0789	Transcriptional regulator
VAB18032_28046	COG1940	carbohydrate kinase activity
VAB18032_28066	COG0142	geranyltranstransferase activity
VAB18032_28106	COG0673	inositol 2-dehydrogenase activity
VAB18032_28116	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB18032_28121	COG1129	ABC transporter
VAB18032_28151	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAB18032_28166	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAB18032_28166	COG0574	Belongs to the PEP-utilizing enzyme family
VAB18032_28201	COG0423	glycine-tRNA ligase activity
VAB18032_28221	COG0803	Belongs to the bacterial solute-binding protein 9 family
VAB18032_28221	COG3443	Belongs to the bacterial solute-binding protein 9 family
VAB18032_28226	COG1121	(ABC) transporter
VAB18032_28231	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VAB18032_28256	COG4821	SIS domain
VAB18032_28271	COG0701	Predicted permease
VAB18032_28276	COG4721	ABC-type cobalt transport system, permease component
VAB18032_28281	COG4172	Belongs to the ABC transporter superfamily
VAB18032_28286	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VAB18032_28291	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VAB18032_28301	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VAB18032_28306	COG1381	Involved in DNA repair and RecF pathway recombination
VAB18032_28321	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAB18032_28336	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VAB18032_28351	COG0537	adenosine 5'-monophosphoramidase activity
VAB18032_28356	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_28366	COG0484	heat shock protein binding
VAB18032_28371	COG1420	regulation of RNA biosynthetic process
VAB18032_28386	COG1024	Enoyl-CoA hydratase
VAB18032_28406	COG0481	GTPase activity
VAB18032_28421	COG0268	Binds directly to 16S ribosomal RNA
VAB18032_28436	COG0658	competence protein
VAB18032_28436	COG2333	competence protein COMEC
VAB18032_28451	COG1307	EDD domain protein, DegV family
VAB18032_28456	COG0406	alpha-ribazole phosphatase activity
VAB18032_28461	COG0799	negative regulation of ribosome biogenesis
VAB18032_28466	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAB18032_28501	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAB18032_28506	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAB18032_28511	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAB18032_28516	COG1530	ribonuclease E activity
VAB18032_28536	COG3046	protein related to deoxyribodipyrimidine photolyase
VAB18032_28541	COG0204	Acyl-transferase
VAB18032_28546	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VAB18032_28551	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAB18032_28556	COG1595	DNA-templated transcription, initiation
VAB18032_28561	COG0105	UTP biosynthetic process
VAB18032_28576	COG0285	dihydrofolate synthase activity
VAB18032_28581	COG0525	valine-tRNA ligase activity
VAB18032_28596	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAB18032_28601	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAB18032_28606	COG0740	serine-type endopeptidase activity
VAB18032_28611	COG0740	serine-type endopeptidase activity
VAB18032_28616	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAB18032_28646	COG1132	(ABC) transporter
VAB18032_28681	COG4552	Acetyltransferase involved in intracellular survival and related
VAB18032_28691	COG0698	ribose 5-phosphate isomerase
VAB18032_28701	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
VAB18032_28711	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
VAB18032_28731	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
VAB18032_28746	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAB18032_28751	COG4569	acetaldehyde dehydrogenase (acetylating) activity
VAB18032_28766	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_28771	COG3844	kynureninase activity
VAB18032_28776	COG3483	tryptophan 2,3-dioxygenase activity
VAB18032_28781	COG1522	sequence-specific DNA binding
VAB18032_28801	COG0668	transmembrane transport
VAB18032_28836	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VAB18032_28841	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB18032_28841	COG0561	phosphatase activity
VAB18032_28851	COG1648	precorrin-2 dehydrogenase activity
VAB18032_28851	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAB18032_28856	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAB18032_28871	COG1797	cobyrinic acid a,c-diamide synthase activity
VAB18032_28881	COG1793	dna ligase
VAB18032_28891	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAB18032_28906	COG1492	cobalamin metabolic process
VAB18032_28911	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VAB18032_28916	COG0629	single-stranded DNA binding
VAB18032_28981	COG1674	ftsk spoiiie
VAB18032_29011	COG0596	Alpha beta hydrolase
VAB18032_29026	COG3795	YCII-related domain
VAB18032_29031	COG4941	Belongs to the sigma-70 factor family
VAB18032_29046	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB18032_29056	COG0596	Alpha beta hydrolase
VAB18032_29066	COG1216	Glycosyl transferase, family 2
VAB18032_29076	COG1132	(ABC) transporter
VAB18032_29081	COG1216	Glycosyl transferase, family 2
VAB18032_29101	COG2197	response regulator
VAB18032_29156	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAB18032_29186	COG1566	PFAM secretion protein HlyD family protein
VAB18032_29201	COG0791	NLP P60 protein
VAB18032_29211	COG1737	Transcriptional regulator
VAB18032_29216	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_29221	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAB18032_29246	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
VAB18032_29251	COG4991	sh3 domain protein
VAB18032_29256	COG1653	transport
VAB18032_29261	COG1175	transmembrane transport
VAB18032_29266	COG0395	ABC-type sugar transport system, permease component
VAB18032_29276	COG0366	Alpha amylase catalytic
VAB18032_29286	COG1070	Carbohydrate kinase
VAB18032_29291	COG2115	Belongs to the xylose isomerase family
VAB18032_29301	COG2208	phosphoserine phosphatase activity
VAB18032_29301	COG2770	Histidine kinase
VAB18032_29326	COG2706	6-phosphogluconolactonase activity
VAB18032_29366	COG5297	Belongs to the glycosyl hydrolase family 6
VAB18032_29381	COG3547	Transposase (IS116 IS110 IS902 family)
VAB18032_29386	COG2902	Dehydrogenase
VAB18032_29396	COG0010	Belongs to the arginase family
VAB18032_29401	COG3118	belongs to the thioredoxin family
VAB18032_29421	COG0183	Belongs to the thiolase family
VAB18032_29471	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAB18032_29496	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
VAB18032_29506	COG0726	polysaccharide deacetylase
VAB18032_29526	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAB18032_29571	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAB18032_29581	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAB18032_29586	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAB18032_29591	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAB18032_29596	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAB18032_29601	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAB18032_29606	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAB18032_29611	COG0356	it plays a direct role in the translocation of protons across the membrane
VAB18032_29626	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAB18032_29631	COG0702	epimerase
VAB18032_29636	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAB18032_29641	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAB18032_29651	COG2890	protein-(glutamine-N5) methyltransferase activity
VAB18032_29656	COG3706	GGDEF domain
VAB18032_29661	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAB18032_29666	COG0254	rRNA binding
VAB18032_29676	COG0083	homoserine kinase activity
VAB18032_29681	COG2814	Major facilitator Superfamily
VAB18032_29686	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAB18032_29696	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAB18032_29706	COG0019	diaminopimelate decarboxylase activity
VAB18032_29711	COG0018	arginyl-trna synthetase
VAB18032_29731	COG1595	DNA-templated transcription, initiation
VAB18032_29741	COG0515	serine threonine protein kinase
VAB18032_29741	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAB18032_29771	COG2409	Drug exporters of the RND superfamily
VAB18032_29786	COG0673	inositol 2-dehydrogenase activity
VAB18032_29816	COG0586	Pfam SNARE associated Golgi protein
VAB18032_29831	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VAB18032_29836	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAB18032_29841	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
VAB18032_29851	COG1028	Short-chain dehydrogenase reductase Sdr
VAB18032_29861	COG1834	amidinotransferase
VAB18032_29866	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAB18032_29876	COG2154	pterin-4-alpha-carbinolamine dehydratase
VAB18032_29906	COG2815	serine threonine protein kinase
VAB18032_29906	COG0515	serine threonine protein kinase
VAB18032_29921	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAB18032_29926	COG2205	protein histidine kinase activity
VAB18032_29931	COG0745	RESPONSE REGULATOR receiver
VAB18032_29951	COG1131	(ABC) transporter
VAB18032_29961	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAB18032_29961	COG0567	Dehydrogenase, E1 component
VAB18032_29971	COG0857	belongs to the CobB CobQ family
VAB18032_29971	COG0280	phosphate acetyltransferase
VAB18032_29976	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAB18032_30016	COG2172	sigma factor antagonist activity
VAB18032_30026	COG1597	lipid kinase activity
VAB18032_30041	COG0175	sulfate reduction
VAB18032_30066	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VAB18032_30109	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAB18032_30124	COG1192	Involved in chromosome partitioning
VAB18032_30129	COG1475	DNA binding
VAB18032_30154	COG1674	ftsk spoiiie
VAB18032_30194	COG0745	RESPONSE REGULATOR receiver
VAB18032_30194	COG3706	GGDEF domain
VAB18032_30204	COG1595	DNA-templated transcription, initiation
VAB18032_30299	COG0739	heme binding