locus-tag class description HUT12_00005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_00025 ENOG4105CHR reductase HUT12_00035 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT12_00040 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT12_00085 ENOG41080XP Cbs domain HUT12_00090 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT12_00095 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_00100 ENOG4105BZU Histidine kinase HUT12_00150 ENOG4107SCK Monooxygenase HUT12_00155 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT12_00170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT12_00175 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT12_00180 ENOG4105CPC Aldo Keto reductase HUT12_00190 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT12_00215 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_00220 ENOG4106PMH Extracellular solute-binding protein family 3 HUT12_00225 ENOG4105E5Q amino acid AbC transporter HUT12_00235 ENOG4107QX3 carboxylase HUT12_00240 ENOG4105C1G acyl-Coa dehydrogenase HUT12_00260 ENOG4108YYC ycei family HUT12_00315 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_00320 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HUT12_00335 ENOG4105TV9 FHA Domain-Containing protein HUT12_00335 ENOG4105TV9 FHA Domain-Containing protein HUT12_00340 ENOG4105HZM Fha domain containing protein HUT12_00355 ENOG4105CJN penicillin-binding protein HUT12_00360 ENOG4107TPY serine threonine protein kinase HUT12_00365 ENOG4105D9P serine threonine protein kinase HUT12_00400 ENOG4105ZJT Cell division protein CrgA HUT12_00405 ENOG4105DF6 Fe-S oxidoreductase HUT12_00410 ENOG4105K4H Nlp p60 protein HUT12_00420 ENOG4105DHP deoxycytidine triphosphate deaminase HUT12_00450 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT12_00490 ENOG4105DYW oxidoreductase HUT12_00505 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HUT12_00510 ENOG4105K6T rare lipoprotein A HUT12_00520 ENOG4105CSU acyl-Coa dehydrogenase HUT12_00530 ENOG4105M4E phosphohistidine phosphatase, SixA HUT12_00555 ENOG4105E7W lamb ycsf family protein HUT12_00575 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT12_00580 ENOG4105CPP Dehydrogenase, E1 component HUT12_00625 ENOG4105CFG Acts as a chaperone (By similarity) HUT12_00630 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT12_00635 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT12_00640 ENOG4105KNI merR family transcriptional Regulator HUT12_00655 ENOG4107W2M Sodium hydrogen exchanger HUT12_00675 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT12_00705 ENOG4105CHR reductase HUT12_00715 ENOG4107YCR Transcriptional regulator, ARSR family HUT12_00725 ENOG4107S1Q Phosphatase HUT12_00740 ENOG41082T9 Membrane HUT12_00745 ENOG4107RCW fructose-bisphosphate aldolase HUT12_00770 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT12_00785 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT12_00820 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_00825 ENOG4105C1G acyl-Coa dehydrogenase HUT12_00835 ENOG4108W9H Tetr family transcriptional regulator HUT12_00845 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT12_00870 ENOG4105CHR reductase HUT12_00875 ENOG4105CHU acetyl-coa acetyltransferase HUT12_00880 ENOG4105C83 adenylosuccinate lyase HUT12_00885 ENOG41082VC UPF0145 protein HUT12_00895 ENOG410839H phosphoribosylformylglycinamidine synthase HUT12_00900 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT12_00905 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT12_00930 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT12_00980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_00985 ENOG4105E39 Enoyl-CoA hydratase HUT12_01035 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT12_01055 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT12_01065 ENOG4105ETE Transcriptional regulator (LacI family HUT12_01070 ENOG4108IJG ABC transporter substrate-binding protein HUT12_01080 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_01085 ENOG4105CG3 alpha amylase, catalytic region HUT12_01185 ENOG4105BZU Histidine kinase HUT12_01200 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_01255 ENOG4107P5I polyketide synthase HUT12_01335 ENOG4105E2Y ABC, transporter HUT12_01350 ENOG4108ZXC Two component transcriptional regulator, luxr family HUT12_01360 ENOG4105DKK Benzoate HUT12_01375 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT12_01380 ENOG4105JXH GntR family transcriptional regulator HUT12_01385 ENOG4105DJ2 Major Facilitator Superfamily HUT12_01395 ENOG4107MMM Anti-sigma-factor antagonist HUT12_01400 ENOG4105FUA antagonist HUT12_01405 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT12_01415 ENOG4105BZU Histidine kinase HUT12_01420 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUT12_01450 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_01465 ENOG4105CQB FAD linked oxidase domain protein HUT12_01490 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT12_01525 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_01530 ENOG4105C1G acyl-Coa dehydrogenase HUT12_01540 ENOG4108W9H Tetr family transcriptional regulator HUT12_01550 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT12_01575 ENOG4105CHR reductase HUT12_01580 ENOG4105CHU acetyl-coa acetyltransferase HUT12_01585 ENOG4105C83 adenylosuccinate lyase HUT12_01590 ENOG41082VC UPF0145 protein HUT12_01600 ENOG410839H phosphoribosylformylglycinamidine synthase HUT12_01605 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT12_01610 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT12_01635 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT12_01685 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_01690 ENOG4105E39 Enoyl-CoA hydratase HUT12_01740 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT12_01760 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT12_01770 ENOG4105ETE Transcriptional regulator (LacI family HUT12_01775 ENOG4108IJG ABC transporter substrate-binding protein HUT12_01785 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_01790 ENOG4105CG3 alpha amylase, catalytic region HUT12_01890 ENOG4105BZU Histidine kinase HUT12_01905 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_01960 ENOG4107P5I polyketide synthase HUT12_02040 ENOG4105E2Y ABC, transporter HUT12_02055 ENOG4108ZXC Two component transcriptional regulator, luxr family HUT12_02065 ENOG4105DKK Benzoate HUT12_02080 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT12_02085 ENOG4105JXH GntR family transcriptional regulator HUT12_02090 ENOG4105DJ2 Major Facilitator Superfamily HUT12_02100 ENOG4107MMM Anti-sigma-factor antagonist HUT12_02105 ENOG4105FUA antagonist HUT12_02110 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT12_02120 ENOG4105BZU Histidine kinase HUT12_02125 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUT12_02155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_02170 ENOG4105CQB FAD linked oxidase domain protein HUT12_02180 ENOG4105BZU Histidine kinase HUT12_02185 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT12_02190 ENOG4105WN5 stage II sporulation protein HUT12_02195 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT12_02200 ENOG4108RH7 phosphoglycerate mutase HUT12_02210 ENOG4107QIV Cytochrome c biogenesis protein HUT12_02220 ENOG4105CRE cytochrome C HUT12_02250 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUT12_02265 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUT12_02275 ENOG4108XM1 transcriptional regulator AsnC family HUT12_02290 ENOG4105C1J atp-dependent rna helicase HUT12_02305 ENOG4105K4H Nlp p60 protein HUT12_02310 ENOG4105DVY radical SAM domain protein HUT12_02330 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT12_02335 ENOG4108U1V ABC transporter, permease HUT12_02340 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT12_02355 ENOG4108M15 ABC transporter HUT12_02360 ENOG4105EEM helicase HUT12_02365 ENOG4105EV6 Pfam:DUF178 HUT12_02380 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT12_02385 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT12_02390 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT12_02395 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT12_02400 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT12_02410 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT12_02420 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_02440 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_02445 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT12_02450 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_02465 ENOG4108IEH NADH dehydrogenase subunit g HUT12_02475 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_02480 ENOG4105DF2 NADH dehydrogenase subunit j HUT12_02485 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_02500 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_02590 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT12_02650 ENOG4105CNU cell division protein FtsK HUT12_02745 ENOG4108I5C dEAD DEAH box helicase HUT12_02750 ENOG4105WN5 stage II sporulation protein HUT12_02760 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT12_02775 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT12_02785 ENOG4108SGK Tetr family transcriptional regulator HUT12_02795 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT12_02800 ENOG4105C6E dna polymerase iii HUT12_02820 ENOG4105MA4 psp1 domain protein HUT12_02860 ENOG4105CAF HipA N-terminal domain protein HUT12_02900 ENOG4108Z0Z intracellular protease Pfpi family HUT12_02910 ENOG41062IR nudix hydrolase HUT12_02915 ENOG4105CPQ Dehydrogenase HUT12_02920 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT12_02930 ENOG41081K0 peptidylprolyl cis-trans isomerase HUT12_02935 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT12_02940 ENOG4105DQE DNA ligase HUT12_02945 ENOG4105DQE DNA ligase HUT12_02975 ENOG4105CFI type iii restriction protein res subunit HUT12_02995 ENOG4105VEQ Cold shock protein HUT12_03000 ENOG4105E63 Pfam:DUF178 HUT12_03010 ENOG4108UIH futalosine nucleosidase HUT12_03015 ENOG4108N0W Major Facilitator superfamily HUT12_03030 ENOG4105C7N Xanthine uracil vitamin C permease HUT12_03040 ENOG4107SFI Major Facilitator superfamily HUT12_03055 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT12_03065 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT12_03075 ENOG4107WI4 Aldose-1-epimerase HUT12_03090 ENOG4105C1G acyl-Coa dehydrogenase HUT12_03105 ENOG4105EJQ L-serine dehydratase HUT12_03115 ENOG4105EY8 ABC transporter HUT12_03125 ENOG4107SJB teichoic acid biosynthesis HUT12_03130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_03230 ENOG4105VPX protein, conserved in bacteria HUT12_03250 ENOG41067RQ csbd family HUT12_03265 ENOG4105BZP glycoside hydrolase 15-related HUT12_03280 ENOG4105KK4 UPF0060 membrane protein HUT12_03290 ENOG4105BZ1 (ABC) transporter HUT12_03305 ENOG4105DBE peroxidase HUT12_03355 ENOG4105R8C Transcriptional regulator HUT12_03360 ENOG4105CPC Aldo Keto reductase HUT12_03370 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_03380 ENOG4105CJ1 ABC, transporter HUT12_03485 ENOG4105EC2 ftsk spoIIIe HUT12_03490 ENOG41087ID Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT12_03520 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_03525 ENOG4106F1P AAA ATPase, central domain protein HUT12_03545 ENOG4105ECR NmrA family HUT12_03555 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT12_03565 ENOG4107SVH Potassium channel protein HUT12_03570 ENOG4105K56 Transcriptional regulator HUT12_03575 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT12_03580 ENOG4105DQU oxidoreductase, subunit beta HUT12_03585 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT12_03590 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT12_03595 ENOG4105EEI dihydropteroate synthase HUT12_03620 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT12_03630 ENOG4108UKI Enoyl-CoA hydratase HUT12_03645 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT12_03650 ENOG4107ZBN O-methyltransferase HUT12_03660 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT12_03675 ENOG4105CJW magnesium transporter HUT12_03680 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT12_03745 ENOG41080RH Thioredoxin HUT12_03775 ENOG4105NAF rna polymerase sigma factor HUT12_03785 ENOG4105DB7 PHP domain protein HUT12_03790 ENOG41081FY multiple antibiotic resistance (MarC)-related HUT12_03830 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT12_03840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT12_03845 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUT12_03865 ENOG4108UXE Protein tyrosine phosphatase HUT12_03875 ENOG41082YX Transcriptional regulator, arsr family HUT12_03890 ENOG410829K Lysine exporter protein (Lyse ygga) HUT12_03910 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT12_03915 ENOG4105E4C Lytic transglycosylase catalytic HUT12_03920 ENOG4108Z6Z Transcriptional regulator HUT12_03940 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUT12_03990 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT12_04005 ENOG4105F8V Hydrolase, tatD family HUT12_04010 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT12_04015 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT12_04020 ENOG4105C5H ABC transporter HUT12_04035 ENOG41067SE Tetr family transcriptional regulator HUT12_04055 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT12_04060 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT12_04065 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT12_04070 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT12_04075 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo HUT12_04090 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT12_04095 ENOG4105CMR udp-glucose 4-epimerase HUT12_04105 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT12_04125 ENOG4105CG3 alpha amylase, catalytic region HUT12_04145 ENOG4105EG2 ABC transporter, permease HUT12_04155 ENOG4105DIH basic membrane HUT12_04165 ENOG4105UIB (ABC) transporter HUT12_04195 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT12_04210 ENOG4105GWZ Roadblock lc7 family protein HUT12_04235 ENOG4108JJ8 (ABC) transporter HUT12_04240 ENOG4108JJ9 ABC, transporter HUT12_04255 ENOG4105C26 Dehydrogenase HUT12_04260 ENOG4105C26 Dehydrogenase HUT12_04265 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUT12_04270 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT12_04290 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT12_04305 ENOG4107RM1 amidohydrolase HUT12_04370 ENOG4108JIK carboxylase HUT12_04390 ENOG4107WR6 Maf-like protein HUT12_04395 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_04435 ENOG4105D8K carboxyl transferase HUT12_04460 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT12_04500 ENOG4108IAB Phoh family HUT12_04540 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT12_04545 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT12_04570 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT12_04620 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT12_04665 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_04705 ENOG4105CHU acetyl-coa acetyltransferase HUT12_04735 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_04740 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT12_04745 ENOG4105DER m42 family HUT12_04755 ENOG4105CAQ asparagine synthetase HUT12_04760 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT12_04765 ENOG4105K59 histidine triad (HIT) protein HUT12_04790 ENOG4105C7B Threonine dehydratase HUT12_04795 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT12_04805 ENOG4105T1M mycothiol conjugate amidase mca HUT12_04815 ENOG4105BZU Histidine kinase HUT12_04820 ENOG4105C7Z Conserved Protein HUT12_04840 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT12_04865 ENOG4105BZ1 (ABC) transporter HUT12_04885 ENOG4105C0Z ABC transporter HUT12_04890 ENOG4108IV0 ABC, transporter HUT12_05000 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT12_05030 ENOG4105PMW Domain of unknown function (DUF1990) HUT12_05055 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT12_05250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_05255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_05265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT12_05300 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_05310 ENOG4105DEN Luciferase family HUT12_05315 ENOG4105F0K SARP family transcriptional regulator HUT12_05330 ENOG4106ARF phosphopantetheine-binding protein HUT12_05335 ENOG4105CZS beta-ketoacyl synthase HUT12_05345 ENOG4107SQU synthase HUT12_05350 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT12_05365 ENOG4105EAD ABC transporter HUT12_05370 ENOG4105DEN Luciferase family HUT12_05395 ENOG4105CHR reductase HUT12_05425 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT12_05445 ENOG4105DYW oxidoreductase HUT12_05450 ENOG4106YT9 Enoyl-CoA hydratase HUT12_05465 ENOG4108M8W Monooxygenase HUT12_05470 ENOG4108M8W Monooxygenase HUT12_05480 ENOG4105D2B acyl-CoA dehydrogenase HUT12_05485 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_05510 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT12_05515 ENOG4105CHU acetyl-coa acetyltransferase HUT12_05530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_05540 ENOG4108JQ6 ABC transporter HUT12_05545 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT12_05550 ENOG4105E9F Enoyl-CoA hydratase HUT12_05590 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT12_05635 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT12_05655 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_05675 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_05690 ENOG4105EW9 transcriptional regulator AsnC family HUT12_05700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_05705 ENOG4105F38 ABC transporter, permease HUT12_05710 ENOG4105D38 putrescine abc transporter HUT12_05725 ENOG4105CYW agmatinase HUT12_05735 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT12_05740 ENOG4106F60 Histidine kinase HUT12_05750 ENOG4105CPF Cell wall formation (By similarity) HUT12_05760 ENOG4106SPC secreted protein HUT12_05790 ENOG4107QKV phosphomannomutase HUT12_05795 ENOG4105W49 UPF0434 protein HUT12_05815 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT12_05840 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_05860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_05880 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT12_05885 ENOG41068WN HUT12_05895 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT12_05920 ENOG4105C26 Dehydrogenase HUT12_05930 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT12_05935 ENOG4105CAK Cell division ATP-binding protein ftsE HUT12_05940 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HUT12_05945 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT12_05960 ENOG4105FP9 thiamine pyrophosphate HUT12_05965 ENOG4108UJU UPF0301 protein HUT12_06085 ENOG4105E5M Multidrug resistance protein D HUT12_06105 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_06115 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_06130 ENOG4106YT9 Enoyl-CoA hydratase HUT12_06135 ENOG4105DYW oxidoreductase HUT12_06140 ENOG4107YCY Transcriptional regulator HUT12_06155 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_06180 ENOG4105CHU acetyl-coa acetyltransferase HUT12_06190 ENOG4105C1G acyl-Coa dehydrogenase HUT12_06195 ENOG4105CI0 Citrate lyase HUT12_06210 ENOG4105C1G acyl-Coa dehydrogenase HUT12_06225 ENOG4108TCS Glutamyl endopeptidase HUT12_06240 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_06260 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_06270 ENOG4105QV4 Tryptophan halogenase HUT12_06300 ENOG4105WQT MbtH domain protein HUT12_06310 ENOG4105CHR reductase HUT12_06350 ENOG4107RUY (E1 component), alpha subunit HUT12_06355 ENOG4105CPP Dehydrogenase, E1 component HUT12_06385 ENOG4105EET magnesium chelatase HUT12_06410 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT12_06460 ENOG4105BZU Histidine kinase HUT12_06465 ENOG4107TXC Transcriptional regulator HUT12_06490 ENOG4105C2C drug resistance transporter, Bcr CflA HUT12_06510 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT12_06545 ENOG4105ECY inositol monophosphatase HUT12_06590 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_06615 ENOG4105CV8 reductase HUT12_06640 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT12_06685 ENOG4105BZU Histidine kinase HUT12_06690 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_06715 ENOG4105IIU Aminopeptidase HUT12_06765 ENOG41065SU Two-component system sensor kinase HUT12_06770 ENOG4108KXV response regulator HUT12_06800 ENOG4105BZP glycoside hydrolase 15-related HUT12_06815 ENOG4105CV8 reductase HUT12_06825 ENOG4105CYP glycoside hydrolase, family HUT12_06830 ENOG41061H0 Monooxygenase HUT12_06835 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT12_06845 ENOG4108RWI nicotinamidase HUT12_06850 ENOG4107RKP Nicotinate phosphoribosyltransferase HUT12_06855 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_06865 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT12_06890 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT12_06900 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT12_06905 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT12_06910 ENOG4105C84 Histidine ammonia-lyase HUT12_06915 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_06925 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HUT12_06930 ENOG4105CGP Urocanate hydratase HUT12_06945 ENOG4105EXC Acyl-transferase HUT12_06975 ENOG4105D3Q Sugar transferase HUT12_06980 ENOG4108KGH TRANSCRIPTIONal HUT12_07030 ENOG4108JJB ABC transporter HUT12_07040 ENOG4108R9S DSBA oxidoreductase HUT12_07085 ENOG4105C57 major facilitator superfamily HUT12_07090 ENOG4108RFG Tetr family transcriptional regulator HUT12_07095 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT12_07100 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT12_07110 ENOG4105EYF MMPL domain protein HUT12_07120 ENOG4105CPC Aldo Keto reductase HUT12_07130 ENOG4105D0M Protease HtpX homolog HUT12_07160 ENOG41065SU Two-component system sensor kinase HUT12_07235 ENOG4105CJ1 ABC, transporter HUT12_07240 ENOG4105DKW ABC transporter HUT12_07245 ENOG4108RVA ribokinase HUT12_07295 ENOG4105VG5 Membrane HUT12_07315 ENOG4105C10 Electron transfer flavoprotein HUT12_07325 ENOG4105K6V RNA polymerase HUT12_07345 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT12_07365 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT12_07370 ENOG4105BZU Histidine kinase HUT12_07375 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT12_07380 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT12_07390 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT12_07395 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT12_07425 ENOG4105ETE Transcriptional regulator (LacI family HUT12_07515 ENOG4105C01 Dihydroxy-acid dehydratase HUT12_07520 ENOG4105BZU Histidine kinase HUT12_07530 ENOG4108ZP8 Acetolactate synthase small subunit HUT12_07535 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT12_07540 ENOG4108JQ1 Dehydrogenase HUT12_07555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT12_07560 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT12_07575 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT12_07590 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_07600 ENOG4107QVM von Willebrand factor, type A HUT12_07605 ENOG4105C0H protease HUT12_07615 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT12_07655 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT12_07660 ENOG4107XER 3-isopropylmalate dehydratase, small subunit HUT12_07665 ENOG4105K70 DNA-binding protein HUT12_07680 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT12_07700 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT12_07705 ENOG4105C28 cystathionine HUT12_07710 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT12_07715 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HUT12_07775 ENOG4105VB9 50S ribosomal protein l28 HUT12_07780 ENOG4105DP4 dak2 domain fusion protein ylov HUT12_07795 ENOG4106H78 methyltransferase HUT12_07800 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT12_07815 ENOG41084BZ 50S ribosomal protein L32 HUT12_07820 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HUT12_07825 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT12_07830 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT12_07840 ENOG4105K4I Scp-like extracellular HUT12_07885 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT12_07920 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HUT12_07930 ENOG4105K5M 30s ribosomal protein S16 HUT12_07935 ENOG41082KU UPF0109 protein HUT12_07940 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT12_07945 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT12_07950 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT12_07965 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT12_07970 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT12_07995 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT12_08010 ENOG41080R2 UPF0102 protein HUT12_08020 ENOG4105CE9 30S ribosomal protein S2 HUT12_08025 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT12_08030 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT12_08035 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT12_08040 ENOG4105KNE Phosphatidate cytidylyltransferase HUT12_08045 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT12_08060 ENOG4107B57 rieske 2fe-2S domain-containing protein HUT12_08085 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT12_08095 ENOG4105DZP Membrane-associated zinc metalloprotease HUT12_08100 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT12_08115 ENOG4105BZ1 (ABC) transporter HUT12_08120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT12_08130 ENOG4105CHF Glutathione S-transferase HUT12_08135 ENOG4105CHU acetyl-coa acetyltransferase HUT12_08160 ENOG4105C26 Dehydrogenase HUT12_08205 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_08225 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT12_08240 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT12_08250 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT12_08255 ENOG4105SFS phosphoesterase RecJ domain protein HUT12_08280 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT12_08290 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT12_08295 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT12_08300 ENOG4105C1V Peptidase, M16 HUT12_08305 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT12_08310 ENOG4105VRR gCN5-related N-acetyltransferase HUT12_08325 ENOG4105T0Z Conserved Protein HUT12_08335 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HUT12_08340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT12_08345 ENOG4105CN5 Metallo-Beta-Lactamase HUT12_08350 ENOG4106T9R serine protease HUT12_08365 ENOG4107QZI cell division protein FtsK HUT12_08385 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT12_08395 ENOG4105CEV competence damage-inducible protein HUT12_08400 ENOG4105WBV Transcriptional regulator HUT12_08415 ENOG4105ETE Transcriptional regulator (LacI family HUT12_08435 ENOG4105DC7 peptidase M24 HUT12_08440 ENOG4108R85 Short chain dehydrogenase HUT12_08445 ENOG4108I5D sulfate abc transporter HUT12_08450 ENOG4105F38 ABC transporter, permease HUT12_08460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_08465 ENOG4107STQ Multicopper oxidase HUT12_08470 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT12_08495 ENOG4107QRT dEAD DEAH box helicase HUT12_08505 ENOG4105D65 subunit l HUT12_08510 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT12_08515 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_08525 ENOG41080TA Multiple resistance and ph regulation protein f HUT12_08530 ENOG4105KJM monovalent cation h antiporter subunit g HUT12_08545 ENOG4105C37 (CBS) domain HUT12_08550 ENOG4108N23 SpoOM-related protein HUT12_08555 ENOG4108NIW Leucine export protein LeuE HUT12_08565 ENOG4105CSW GntR family transcriptional regulator HUT12_08570 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HUT12_08575 ENOG4105DXI Major Facilitator superfamily HUT12_08585 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT12_08590 ENOG4105KC9 Modulates RecA activity (By similarity) HUT12_08595 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HUT12_08600 ENOG4105DRP amino acid AbC transporter HUT12_08605 ENOG4105EAD ABC transporter HUT12_08610 ENOG4107UBR Extracellular solute-binding protein family 3 HUT12_08615 ENOG4105CDA abc transporter atp-binding protein HUT12_08620 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HUT12_08635 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT12_08640 ENOG4105DBA pectate lyase HUT12_08645 ENOG4105C99 atpase involved in dna repair HUT12_08655 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT12_08660 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT12_08670 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT12_08680 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT12_08685 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT12_08690 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT12_08730 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT12_08740 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT12_08745 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT12_08750 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_08755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_08760 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component HUT12_08765 ENOG4107QKW extracellular solute-binding protein family 1 HUT12_08785 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT12_08795 ENOG4105EN6 Membrane HUT12_08840 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT12_08865 ENOG4107VEG TrkA-N domain protein HUT12_08870 ENOG4105C0X amino acid HUT12_08875 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT12_08880 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT12_08900 ENOG4105DRR Transcriptional regulator, GntR family HUT12_08910 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT12_08940 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT12_08945 ENOG4106F60 Histidine kinase HUT12_08965 ENOG4105CHU acetyl-coa acetyltransferase HUT12_08970 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HUT12_08980 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT12_08985 ENOG4105C1Q protoporphyrinogen oxidase HUT12_08990 ENOG4107JTW chlorite dismutase HUT12_08995 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_09020 ENOG4105E0X reductase HUT12_09025 ENOG4105DQE DNA ligase HUT12_09055 ENOG4105C39 capsular polysaccharide phosphotransferase HUT12_09095 ENOG4105EYH Exonuclease HUT12_09100 ENOG4107RH8 nuclease SbcCD subunit D HUT12_09135 ENOG4105DRS transport system, permease HUT12_09145 ENOG4105ETE Transcriptional regulator (LacI family HUT12_09155 ENOG4105C1G acyl-Coa dehydrogenase HUT12_09200 ENOG4105CYP glycoside hydrolase, family HUT12_09220 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT12_09225 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT12_09230 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT12_09380 ENOG4108S01 response regulator HUT12_09425 ENOG4108ZJ4 polysaccharide deacetylase HUT12_09440 ENOG4105ETE Transcriptional regulator (LacI family HUT12_09445 ENOG4105ETE Transcriptional regulator (LacI family HUT12_09480 ENOG4108YV4 Universal stress protein HUT12_09500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT12_09515 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT12_09530 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_09540 ENOG4108N23 SpoOM-related protein HUT12_09555 ENOG4105EEM helicase HUT12_09570 ENOG4108UYE Lactoylglutathione lyase HUT12_09580 ENOG4105EYW Ion transport protein HUT12_09605 ENOG4105CHR reductase HUT12_09610 ENOG4105KF0 sporulation and cell division protein, SsgA HUT12_09665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_09685 ENOG4105ETE Transcriptional regulator (LacI family HUT12_09725 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT12_09735 ENOG410901E Membrane HUT12_09775 ENOG4105E0A ABC, transporter HUT12_09785 ENOG4105S6R Iron-hydroxamate transporter permease subunit HUT12_09800 ENOG4105CPQ Dehydrogenase HUT12_09820 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_09825 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_09835 ENOG4107TY6 Acylneuraminate cytidylyltransferase HUT12_09850 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT12_09855 ENOG4105C5E polysaccharide biosynthesis protein HUT12_09875 ENOG4105CHR reductase HUT12_09885 ENOG4105D2T synthase HUT12_09890 ENOG4105K64 Glycosyl transferase, family 2 HUT12_09930 ENOG4105EY8 ABC transporter HUT12_09940 ENOG4108JGH Tetr family transcriptional regulator HUT12_09960 ENOG4105XJC Two component transcriptional regulator (Winged helix family HUT12_09965 ENOG4105BZU Histidine kinase HUT12_09970 ENOG4105H1G trap transporter solute receptor taxi family HUT12_09980 ENOG4107XFJ UPF0246 protein HUT12_10000 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT12_10005 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT12_10020 ENOG4107QPH glycogen) synthase HUT12_10025 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT12_10040 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT12_10045 ENOG4107STW synthase HUT12_10065 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT12_10075 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT12_10085 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUT12_10110 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT12_10140 ENOG4105C5E polysaccharide biosynthesis protein HUT12_10145 ENOG4105D3Q Sugar transferase HUT12_10165 ENOG4105BZM domain protein HUT12_10170 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT12_10190 ENOG4105E33 succinate dehydrogenase HUT12_10205 ENOG4105DUM transcriptional regulator, lysR family HUT12_10210 ENOG4105CQ7 ATP-dependent helicase HUT12_10235 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT12_10255 ENOG4105CGK Exodeoxyribonuclease III HUT12_10285 ENOG4105C26 Dehydrogenase HUT12_10290 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_10310 ENOG4105CQ7 ATP-dependent helicase HUT12_10330 ENOG4105CUB amino acid HUT12_10360 ENOG4105EUB pirin domain protein HUT12_10370 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_10375 ENOG4107VFM Dehydrogenase HUT12_10420 ENOG4107U9T Pfam:Ribonuclease_BN HUT12_10440 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT12_10450 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUT12_10460 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT12_10465 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT12_10470 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT12_10480 ENOG4105D16 lipopolysaccharide heptosyltransferase i HUT12_10510 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT12_10515 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_10520 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT12_10560 ENOG4105VEQ Cold shock protein HUT12_10570 ENOG4105CPC Aldo Keto reductase HUT12_10575 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT12_10595 ENOG4105C22 threonyL-tRNA synthetase HUT12_10620 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT12_10625 ENOG4105E2K Glycosyl transferase (Group 1 HUT12_10635 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT12_10640 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT12_10660 ENOG4105CDY transcriptional regulatory protein HUT12_10705 ENOG4108IUX (ABC) transporter HUT12_10710 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_10715 ENOG4108ZGX Histidine kinase HUT12_10725 ENOG4105D0M Protease HtpX homolog HUT12_10730 ENOG4108V0P LemA family HUT12_10745 ENOG4105C0B DNA polymerase III (alpha subunit) HUT12_10765 ENOG4105C57 major facilitator superfamily HUT12_10770 ENOG4108JGH Tetr family transcriptional regulator HUT12_10775 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT12_10785 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUT12_10790 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT12_10795 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT12_10800 ENOG4105VIE preprotein translocase, subunit YajC HUT12_10815 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT12_10820 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT12_10825 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUT12_10840 ENOG4105CUT histidyl-tRNA synthetase HUT12_10860 ENOG4106NMR serine protease HUT12_10865 ENOG4105C9M aspartyl-trna synthetase HUT12_10885 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_10920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT12_10925 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT12_10935 ENOG4105E2X shikimate dehydrogenase HUT12_10955 ENOG4108UW5 maltose o-acetyltransferase HUT12_11000 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT12_11005 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT12_11010 ENOG4105D49 3-dehydroquinate synthase HUT12_11015 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT12_11020 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT12_11025 ENOG410803B Involved in the transcription termination process (By similarity) HUT12_11035 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT12_11040 ENOG4105CXT aspartate transcarbamylase HUT12_11045 ENOG4105CD3 dihydroorotase HUT12_11050 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT12_11060 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT12_11065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_11070 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT12_11080 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUT12_11085 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT12_11095 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_11100 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_11110 ENOG4108Z4J Cytidine monophosphate kinase HUT12_11115 ENOG4106A3M Cytochrome p-450 HUT12_11120 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_11125 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT12_11150 ENOG4105ETX regulatoR HUT12_11165 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT12_11170 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT12_11195 ENOG4105CDA abc transporter atp-binding protein HUT12_11200 ENOG4105EAD ABC transporter HUT12_11205 ENOG4105CT1 (ABC) transporter HUT12_11210 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT12_11215 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT12_11230 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUT12_11235 ENOG41084BS 50S ribosomal protein L35 HUT12_11240 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT12_11245 ENOG4108RWN rrna methyltransferase HUT12_11250 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT12_11255 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT12_11260 ENOG4107V6Q Cyclic nucleotide-binding domain HUT12_11280 ENOG4108IJ1 Dehydrogenase HUT12_11290 ENOG4105CMR udp-glucose 4-epimerase HUT12_11295 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT12_11300 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT12_11305 ENOG4105CAS nag kinase HUT12_11310 ENOG4105C8Y Acetylornithine aminotransferase HUT12_11315 ENOG4105DBV ornithine carbamoyltransferase HUT12_11325 ENOG4105CH7 arginosuccinase HUT12_11335 ENOG4108VX5 3-methyladenine DNA glycosylase HUT12_11345 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HUT12_11355 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_11365 ENOG4108YV4 Universal stress protein HUT12_11400 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HUT12_11410 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT12_11435 ENOG4105DSU hydrolase HUT12_11460 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT12_11465 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT12_11490 ENOG4107QPH glycogen) synthase HUT12_11500 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT12_11505 ENOG4108YZ4 nudix hydrolase HUT12_11535 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT12_11540 ENOG4105FE9 pseudouridine synthase HUT12_11545 ENOG4105CAT Cytidine monophosphate kinase HUT12_11550 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT12_11570 ENOG4107QN1 sodium solute HUT12_11590 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT12_11605 ENOG4105SC1 monovalent cation H antiporter subunit E HUT12_11610 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_11615 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT12_11620 ENOG4105D65 subunit l HUT12_11630 ENOG4105CZN Potassium uptake protein HUT12_11635 ENOG4105DIM ABC transporter HUT12_11640 ENOG4105CIG ABC transporter HUT12_11645 ENOG4108X07 Tetr family transcriptional regulator HUT12_11655 ENOG4105EHG Permease protein HUT12_11665 ENOG4105NZG Ferredoxin HUT12_11685 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT12_11690 ENOG4105CAQ asparagine synthetase HUT12_11695 ENOG4105C5F glutamine synthetase HUT12_11810 ENOG4105BZU Histidine kinase HUT12_11815 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_11895 ENOG4107SJ9 decarboxylase HUT12_11975 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HUT12_11995 ENOG4105K6V RNA polymerase HUT12_12030 ENOG4105E2R ROK family HUT12_12045 ENOG4108WQI RNA Polymerase HUT12_12050 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_12055 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUT12_12060 ENOG410680H amp-dependent synthetase and ligase HUT12_12065 ENOG4105E2T synthase III HUT12_12120 ENOG4105CNN ABC, transporter HUT12_12125 ENOG4105C2J ABC transporter HUT12_12150 ENOG4105IKQ hydratase HUT12_12155 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_12160 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_12210 ENOG4107RB3 L-asparaginase HUT12_12270 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_12275 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_12285 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_12295 ENOG4105C84 Histidine ammonia-lyase HUT12_12320 ENOG4105ETX regulatoR HUT12_12325 ENOG4105BZU Histidine kinase HUT12_12340 ENOG4105KVH Transcriptional regulator HUT12_12370 ENOG4105D74 hydrolase HUT12_12415 ENOG4107S5I aldo keto reductase HUT12_12425 ENOG4105C26 Dehydrogenase HUT12_12440 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_12455 ENOG4105KNY Microcompartments protein HUT12_12465 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT12_12475 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HUT12_12490 ENOG4107EFR Flavocytochrome c HUT12_12495 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_12500 ENOG4108UAU isochorismatase HUT12_12505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_12510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_12515 ENOG4105C3U ABC transporter HUT12_12525 ENOG4105DRR Transcriptional regulator, GntR family HUT12_12540 ENOG4105KVH Transcriptional regulator HUT12_12565 ENOG4108KX4 response regulator HUT12_12570 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT12_12575 ENOG4105C1G acyl-Coa dehydrogenase HUT12_12660 ENOG4105WN5 stage II sporulation protein HUT12_12725 ENOG4105C57 major facilitator superfamily HUT12_12750 ENOG4105C1G acyl-Coa dehydrogenase HUT12_12755 ENOG4107258 Transcriptional regulator HUT12_12760 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_12780 ENOG4105C32 Amino acid ABC transporter (Permease) HUT12_12790 ENOG4105C0Z ABC transporter HUT12_12795 ENOG4108IV0 ABC, transporter HUT12_12800 ENOG4107RUY (E1 component), alpha subunit HUT12_12805 ENOG4105CPP Dehydrogenase, E1 component HUT12_12815 ENOG4105C7K acetolactate synthase HUT12_12820 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_12845 ENOG4105EC2 ftsk spoIIIe HUT12_12905 ENOG4106F1P AAA ATPase, central domain protein HUT12_12935 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUT12_12950 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT12_12960 ENOG4108Z6Z Transcriptional regulator HUT12_12965 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_13005 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_13025 ENOG4105BZU Histidine kinase HUT12_13030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_13040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_13045 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_13075 ENOG4107QUY Guanine deaminase HUT12_13105 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT12_13120 ENOG4105EYF MMPL domain protein HUT12_13130 ENOG4107YBY Hydrolase HUT12_13225 ENOG4105DHI Methyltransferase HUT12_13260 ENOG4105CJ1 ABC, transporter HUT12_13300 ENOG4105BZ1 (ABC) transporter HUT12_13305 ENOG4105BZ1 (ABC) transporter HUT12_13320 ENOG4105DK7 lysyl-tRNA synthetase HUT12_13325 ENOG4105DG4 malate L-lactate dehydrogenase HUT12_13350 ENOG4106V2I dimethylaminohydrolase HUT12_13360 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_13385 ENOG4108JJB ABC transporter HUT12_13390 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HUT12_13395 ENOG4108K4B hydrolase HUT12_13410 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT12_13415 ENOG4106KS4 Sulfatase HUT12_13420 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT12_13430 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_13440 ENOG4105EWK phytoene HUT12_13475 ENOG4105C9B Cysteine desulfurase HUT12_13560 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_13565 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_13585 ENOG4105KNY Microcompartments protein HUT12_13605 ENOG4107TYC hydantoinase B oxoprolinase HUT12_13610 ENOG4107HP6 Transcriptional regulator HUT12_13615 ENOG4105C7K acetolactate synthase HUT12_13620 ENOG4105E39 Enoyl-CoA hydratase HUT12_13625 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT12_13630 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_13660 ENOG41083YR Protein CrcB homolog HUT12_13665 ENOG41083TI Protein CrcB homolog HUT12_13730 ENOG4105CT1 (ABC) transporter HUT12_13735 ENOG4105E5Q amino acid AbC transporter HUT12_13740 ENOG4105DRP amino acid AbC transporter HUT12_13775 ENOG4105BZU Histidine kinase HUT12_13780 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_13790 ENOG4105NPE arsR family transcriptional regulator HUT12_13805 ENOG4106NZI LysR family Transcriptional regulator HUT12_13835 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HUT12_13870 ENOG4105KVH Transcriptional regulator HUT12_13910 ENOG4105C57 major facilitator superfamily HUT12_13915 ENOG4108RFG Tetr family transcriptional regulator HUT12_13970 ENOG41082BM Transcriptional regulator, arsr family HUT12_13985 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases HUT12_13990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT12_13995 ENOG4107QR9 Iron-sulfur cluster binding protein HUT12_14000 ENOG41080R8 Conserved Protein HUT12_14020 ENOG4105CHU acetyl-coa acetyltransferase HUT12_14025 ENOG41090TK Short-chain dehydrogenase reductase Sdr HUT12_14035 ENOG410846T CoA-transferase family III HUT12_14050 ENOG4108KC2 acyl-Coa dehydrogenase HUT12_14055 ENOG4105EFA 4-hydroxyphenylacetate HUT12_14060 ENOG4105D2B acyl-CoA dehydrogenase HUT12_14075 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_14080 ENOG4105E39 Enoyl-CoA hydratase HUT12_14085 ENOG4108SGK Tetr family transcriptional regulator HUT12_14090 ENOG4105DND Transcriptional regulator HUT12_14105 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component HUT12_14110 ENOG4105C1G acyl-Coa dehydrogenase HUT12_14120 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_14175 ENOG4105CEP NADH dehydrogenase HUT12_14185 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUT12_14195 ENOG4108T5E Copper resistance protein HUT12_14225 ENOG4105CMG Carbohydrate kinase HUT12_14235 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT12_14245 ENOG4107VUR extracellular solute-binding protein HUT12_14260 ENOG4105DRR Transcriptional regulator, GntR family HUT12_14270 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT12_14275 ENOG4105DEG Vwa containing coxe family protein HUT12_14350 ENOG4108M8W Monooxygenase HUT12_14365 ENOG4105KDC 50s ribosomal protein l28 HUT12_14370 ENOG4105W0E 50S ribosomal protein L33 HUT12_14375 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT12_14395 ENOG4107TYG Oxidoreductase domain-containing protein HUT12_14400 ENOG4105BZ7 extracellular solute-binding protein family 1 HUT12_14405 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_14415 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HUT12_14420 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_14425 ENOG4107R0V Pyruvate dehydrogenase HUT12_14455 ENOG4105NPE arsR family transcriptional regulator HUT12_14460 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HUT12_14490 ENOG4105BZU Histidine kinase HUT12_14495 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_14510 ENOG4108JA1 polyketide synthase HUT12_14510 ENOG4108JA1 polyketide synthase HUT12_14520 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT12_14525 ENOG4105C57 major facilitator superfamily HUT12_14540 ENOG4108RZE Tetr family transcriptional regulator HUT12_14555 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_14585 ENOG4105WBV Transcriptional regulator HUT12_14595 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HUT12_14600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_14625 ENOG410880H cysteine synthase HUT12_14635 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT12_14685 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_14695 ENOG4105C2J ABC transporter HUT12_14700 ENOG4105CNN ABC, transporter HUT12_14705 ENOG4105CNN ABC, transporter HUT12_14710 ENOG4105DFW ABC transporter HUT12_14715 ENOG4107TTA Xylose isomerase domain protein TIM barrel HUT12_14725 ENOG4108VEQ Superoxide dismutase HUT12_14750 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_14765 ENOG4107XKF NMT1 THI5 Like Domain Protein HUT12_14790 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_14800 ENOG4105DYW oxidoreductase HUT12_14825 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT12_14835 ENOG4105JXH GntR family transcriptional regulator HUT12_14860 ENOG4107TUS Dihydrodipicolinate synthase HUT12_14870 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT12_14895 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_14930 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_14935 ENOG4105F38 ABC transporter, permease HUT12_14940 ENOG4105C26 Dehydrogenase HUT12_14950 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_14955 ENOG4105ETE Transcriptional regulator (LacI family HUT12_14960 ENOG4105C7K acetolactate synthase HUT12_14965 ENOG4105C26 Dehydrogenase HUT12_14970 ENOG4107THD Involved in phosphonate degradation (By similarity) HUT12_14980 ENOG41080QX K07048 phosphotriesterase-related protein HUT12_14985 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT12_15000 ENOG4105C26 Dehydrogenase HUT12_15005 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT12_15010 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT12_15030 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_15040 ENOG4105CMG Carbohydrate kinase HUT12_15045 ENOG4105CPQ Dehydrogenase HUT12_15050 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUT12_15065 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUT12_15075 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HUT12_15085 ENOG4105CTK cobaltochelatase, cobn subunit HUT12_15090 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUT12_15130 ENOG4108M0I Transcriptional regulator HUT12_15135 ENOG4105CIR epoxide hydrolase HUT12_15150 ENOG4108ZGX Histidine kinase HUT12_15155 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_15160 ENOG4107SMB hydrolase Family 5 HUT12_15165 ENOG4105CFG Acts as a chaperone (By similarity) HUT12_15190 ENOG4105EYW Ion transport protein HUT12_15220 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_15225 ENOG4105DQ4 alcohol dehydrogenase HUT12_15240 ENOG4108W5M transcriptional regulator HUT12_15245 ENOG4105DHU Bile acid HUT12_15255 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT12_15295 ENOG4105CTU Proline racemase HUT12_15300 ENOG4105C26 Dehydrogenase HUT12_15305 ENOG4108WYP Transcriptional regulator HUT12_15310 ENOG4105BZ1 (ABC) transporter HUT12_15315 ENOG4105BZ1 (ABC) transporter HUT12_15325 ENOG4106IQC argininosuccinate lyase HUT12_15340 ENOG4108I5D sulfate abc transporter HUT12_15345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_15355 ENOG4105E2R ROK family HUT12_15360 ENOG4107RSM transcriptional regulator HUT12_15365 ENOG4108FN7 Aldo keto reductase HUT12_15395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_15400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_15410 ENOG4108JQ7 (ABC) transporter HUT12_15415 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family HUT12_15420 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HUT12_15425 ENOG4108I5D sulfate abc transporter HUT12_15430 ENOG4105ECW sulfate abc transporter HUT12_15435 ENOG4108IJ6 ABC transporter HUT12_15445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_15455 ENOG4105D7T ABC transporter HUT12_15475 ENOG4105D7K pfkb domain protein HUT12_15485 ENOG4105ETE Transcriptional regulator (LacI family HUT12_15495 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_15520 ENOG4105DFW ABC transporter HUT12_15530 ENOG4108HWW ABC transporter HUT12_15540 ENOG4105EX0 alpha-galactosidase HUT12_15545 ENOG4105EF1 ribulokinase HUT12_15555 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT12_15560 ENOG4105C2J ABC transporter HUT12_15565 ENOG4107R9N ABC transporter HUT12_15570 ENOG41062B0 ABC transporter, permease HUT12_15575 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HUT12_15595 ENOG4105ETE Transcriptional regulator (LacI family HUT12_15605 ENOG4107S46 esterase, PHB depolymerase HUT12_15615 ENOG4105C2J ABC transporter HUT12_15620 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT12_15625 ENOG4105DIA mandelate racemase muconate lactonizing HUT12_15640 ENOG4105CPQ Dehydrogenase HUT12_15645 ENOG4105CHR reductase HUT12_15710 ENOG4108TMH cytolethal distending toxin HUT12_15725 ENOG4108M15 ABC transporter HUT12_15735 ENOG4107Z3H Transcriptional regulator, TetR family HUT12_15760 ENOG4105EMU Dehydrogenase HUT12_15840 ENOG4105VMP Transcriptional regulator HUT12_15850 ENOG4105ETE Transcriptional regulator (LacI family HUT12_15855 ENOG4105ETE Transcriptional regulator (LacI family HUT12_15870 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT12_15900 ENOG4107S46 esterase, PHB depolymerase HUT12_15925 ENOG4106F60 Histidine kinase HUT12_15930 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT12_15935 ENOG4105C0H protease HUT12_15940 ENOG4107QVM von Willebrand factor, type A HUT12_15950 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_15960 ENOG4107QP8 phosphohexose isomerase HUT12_15965 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HUT12_15970 ENOG4108N23 SpoOM-related protein HUT12_16060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_16065 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_16095 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_16100 ENOG4105BZU Histidine kinase HUT12_16115 ENOG4106T9R serine protease HUT12_16135 ENOG41082SX arsR family transcriptional regulator HUT12_16155 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_16180 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_16200 ENOG4105DSG hydrolase family 43 HUT12_16220 ENOG4107HP6 Transcriptional regulator HUT12_16225 ENOG4108UHU Aldolase HUT12_16230 ENOG4105D7K pfkb domain protein HUT12_16235 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT12_16265 ENOG4107R9S Malate synthase HUT12_16285 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT12_16290 ENOG4105EHG Permease protein HUT12_16295 ENOG4107R4I Periplasmic binding protein HUT12_16375 ENOG4105C2C drug resistance transporter, Bcr CflA HUT12_16405 ENOG4105E98 transcriptional regulator DeoR family HUT12_16425 ENOG4105CPQ Dehydrogenase HUT12_16450 ENOG4108YYH Nadph-dependent fmn reductase HUT12_16485 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HUT12_16515 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT12_16530 ENOG4105CF7 AraC family transcriptional regulator HUT12_16545 ENOG4105ERH Fumarylacetoacetate hydrolase HUT12_16570 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT12_16585 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT12_16605 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_16640 ENOG4105C3J Cysteine desulfurase HUT12_16645 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HUT12_16650 ENOG4108YYC ycei family HUT12_16735 ENOG4105BZU Histidine kinase HUT12_16750 ENOG4107AQZ Membrane HUT12_16755 ENOG4105C0X amino acid HUT12_16760 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT12_16785 ENOG4105C75 arginyL-tRNA synthetase HUT12_16800 ENOG4107S91 Sodium hydrogen exchanger HUT12_16815 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT12_16835 ENOG4108RNG Permease of the drug metabolite transporter HUT12_16910 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_16915 ENOG4105BZU Histidine kinase HUT12_16935 ENOG4107VXZ Hydrolase HUT12_16940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_16945 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_16950 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_16955 ENOG4105BZU Histidine kinase HUT12_16985 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT12_16995 ENOG4105E5F proteasome HUT12_17000 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT12_17010 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT12_17015 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT12_17040 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUT12_17060 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT12_17080 ENOG4107TMB Transcriptional regulator HUT12_17090 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT12_17115 ENOG4105DSG hydrolase family 43 HUT12_17135 ENOG4105CSU acyl-Coa dehydrogenase HUT12_17140 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUT12_17150 ENOG4105C0Z ABC transporter HUT12_17155 ENOG4108IV0 ABC, transporter HUT12_17160 ENOG4105C32 Amino acid ABC transporter (Permease) HUT12_17165 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT12_17195 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_17265 ENOG4107YCY Transcriptional regulator HUT12_17290 ENOG4105C1G acyl-Coa dehydrogenase HUT12_17300 ENOG4108Z7F N-acetyltransferase HUT12_17305 ENOG4105EGE secreted protein HUT12_17315 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT12_17320 ENOG4105CIR epoxide hydrolase HUT12_17345 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HUT12_17350 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT12_17355 ENOG4105F2Z 3-oxoadipate enol-lactonase HUT12_17360 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUT12_17365 ENOG4107HP6 Transcriptional regulator HUT12_17425 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUT12_17430 ENOG4105C8U phosphate abc transporter HUT12_17435 ENOG4105E2Z phosphate ABC transporter (Permease HUT12_17440 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT12_17445 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUT12_17470 ENOG4108KHX Diguanylate cyclase HUT12_17495 ENOG4107QPV Serine Threonine protein kinase HUT12_17515 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT12_17535 ENOG4105DZ1 carboxypeptidase HUT12_17540 ENOG4105DZ1 carboxypeptidase HUT12_17545 ENOG4108UQS dipeptidase HUT12_17565 ENOG4105D65 subunit l HUT12_17570 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT12_17575 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_17585 ENOG41080TA Multiple resistance and ph regulation protein f HUT12_17595 ENOG4105E0Y RtcB Protein HUT12_17625 ENOG4107QRS glycosyltransferase group 2 family protein HUT12_17630 ENOG4105C8Y Acetylornithine aminotransferase HUT12_17635 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUT12_17640 ENOG4106YN8 Prenyltransferase HUT12_17650 ENOG4105K64 Glycosyl transferase, family 2 HUT12_17680 ENOG4108M15 ABC transporter HUT12_17685 ENOG4105BZU Histidine kinase HUT12_17690 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_17725 ENOG4105CPK Glycosyl transferase (Group 1 HUT12_17740 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUT12_17745 ENOG4105WCJ ec 1.1.1.193 HUT12_17770 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT12_17780 ENOG4105DUU IucA IucC family protein HUT12_17805 ENOG41060NJ transcriptional regulator HUT12_17830 ENOG4105HFS 5'-3' exonuclease HUT12_17840 ENOG4105C1G acyl-Coa dehydrogenase HUT12_17845 ENOG4105J0Q Transcriptional regulator HUT12_17850 ENOG4105CVJ phosphoglycerate mutase HUT12_17865 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HUT12_17870 ENOG4105FRY Dehydrogenase HUT12_17875 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_17880 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit HUT12_17885 ENOG4107CHF 5,6-aminomutase beta subunit HUT12_17890 ENOG4108UYI beta-alanyl-CoA ammonia lyase HUT12_17915 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT12_17925 ENOG4105Q70 HUT12_17940 ENOG4105ETE Transcriptional regulator (LacI family HUT12_17950 ENOG4105E2R ROK family HUT12_17965 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT12_17970 ENOG4105CJQ hydrolase, family 31 HUT12_17980 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_17985 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT12_18010 ENOG41087EV Hsp20/alpha crystallin family HUT12_18015 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT12_18025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_18030 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_18045 ENOG4107W53 thymidine kinase HUT12_18050 ENOG4105DEU major facilitator superfamily HUT12_18075 ENOG4105PSQ Acyl-transferase HUT12_18080 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT12_18085 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT12_18105 ENOG4105CHR reductase HUT12_18115 ENOG4105QPS Monooxygenase HUT12_18125 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT12_18135 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_18150 ENOG4105C26 Dehydrogenase HUT12_18160 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_18175 ENOG4105CD3 dihydroorotase HUT12_18235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_18250 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT12_18265 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT12_18365 ENOG4105EM7 Selenocysteine-specific translation elongation factor HUT12_18385 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HUT12_18410 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT12_18415 ENOG4107QZT geranylgeranyl reductase HUT12_18445 ENOG4105C5X domain protein HUT12_18480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_18485 ENOG4105EPJ extracellular solute-binding protein family 1 HUT12_18490 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HUT12_18495 ENOG4105F0K SARP family transcriptional regulator HUT12_18515 ENOG4105DDN Pentapeptide repeat-containing protein HUT12_18520 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT12_18560 ENOG4105K5B UPF0225 protein HUT12_18590 ENOG4105CBC glutamate synthase HUT12_18600 ENOG4105CSW GntR family transcriptional regulator HUT12_18615 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_18635 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT12_18640 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_18650 ENOG4108RTU Aldolase HUT12_18655 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_18660 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT12_18695 ENOG4108KPJ rna polymerase sigma factor HUT12_18700 ENOG4105ECP epimerase HUT12_18745 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_18795 ENOG4105T38 integral membrane protein HUT12_18800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_18805 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HUT12_18845 ENOG4105CHR reductase HUT12_18850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT12_18855 ENOG4105DTA methyltransferase HUT12_18860 ENOG4105CMR udp-glucose 4-epimerase HUT12_18905 ENOG4105DXX methyltransferase HUT12_18920 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HUT12_18960 ENOG4108Z6Z Transcriptional regulator HUT12_18965 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT12_18980 ENOG41065SU Two-component system sensor kinase HUT12_18985 ENOG4108KXV response regulator HUT12_19000 ENOG4105WN5 stage II sporulation protein HUT12_19045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT12_19065 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUT12_19075 ENOG4105CHR reductase HUT12_19080 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_19085 ENOG4105F2C Acetyl-CoA acetyltransferase HUT12_19095 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT12_19100 ENOG4105CJP fad dependent oxidoreductase HUT12_19110 ENOG4105C0W non-ribosomal peptide synthetase HUT12_19120 ENOG4107QVI Methyltransferase, type 11 HUT12_19130 ENOG4105CJP fad dependent oxidoreductase HUT12_19145 ENOG4105CC9 acyl-Coa dehydrogenase HUT12_19150 ENOG4108KC2 acyl-Coa dehydrogenase HUT12_19180 ENOG4105C0W non-ribosomal peptide synthetase HUT12_19185 ENOG4105C0W non-ribosomal peptide synthetase HUT12_19210 ENOG4106A3M Cytochrome p-450 HUT12_19225 ENOG4106A3M Cytochrome p-450 HUT12_19270 ENOG4105CHR reductase HUT12_19280 ENOG4105C26 Dehydrogenase HUT12_19310 ENOG4105E2Y ABC, transporter HUT12_19315 ENOG4105C0Z ABC transporter HUT12_19330 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HUT12_19335 ENOG41083Z3 extracellular ligand-binding receptor HUT12_19355 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT12_19370 ENOG4105KI2 Urea amidohydrolase subunit beta HUT12_19380 ENOG4107R0W ABC transporter HUT12_19385 ENOG4105DRP amino acid AbC transporter HUT12_19390 ENOG4105CDA abc transporter atp-binding protein HUT12_19425 ENOG4105DIM ABC transporter HUT12_19430 ENOG4105CIG ABC transporter HUT12_19445 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT12_19450 ENOG4107FW0 short-chain dehydrogenase reductase HUT12_19455 ENOG4107TTQ Alpha beta hydrolase fold HUT12_19490 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT12_19495 ENOG4105GVF (ABC) transporter HUT12_19500 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_19505 ENOG4105E2Y ABC, transporter HUT12_19510 ENOG4105D63 family UPF0324 HUT12_19525 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT12_19540 ENOG4105BZU Histidine kinase HUT12_19550 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HUT12_19565 ENOG4105I82 acetyl xylan esterase HUT12_19585 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT12_19590 ENOG4105XN3 extracellular solute-binding protein family 1 HUT12_19615 ENOG4108JJB ABC transporter HUT12_19630 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HUT12_19690 ENOG4107SJ9 decarboxylase HUT12_19705 ENOG4105PDP Short chain dehydrogenase HUT12_19735 ENOG4105EGE secreted protein HUT12_19740 ENOG4107RSM transcriptional regulator HUT12_19745 ENOG4105CHR reductase HUT12_19750 ENOG4108R86 Transcriptional regulator HUT12_19760 ENOG4105C3R Methionine synthase HUT12_19775 ENOG4105C8N cysteinyl-tRNA synthetase HUT12_19805 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT12_19810 ENOG4105DYW oxidoreductase HUT12_19815 ENOG4105CPC Aldo Keto reductase HUT12_19830 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT12_19860 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT12_19880 ENOG4105EC2 ftsk spoIIIe HUT12_19900 ENOG4107W19 lmbE family HUT12_19920 ENOG4107NHD transcriptional regulator HUT12_19925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_19940 ENOG4105JXB ankyrin repeat-containing protein HUT12_19960 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT12_19965 ENOG4105C3Q Glycosyl transferase, family 2 HUT12_19975 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT12_19980 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT12_20005 ENOG4105EYF MMPL domain protein HUT12_20030 ENOG4105CDH Citrulline--aspartate ligase HUT12_20035 ENOG4108M0I Transcriptional regulator HUT12_20125 ENOG4105BZU Histidine kinase HUT12_20130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_20160 ENOG4105WN5 stage II sporulation protein HUT12_20175 ENOG4105WN5 stage II sporulation protein HUT12_20195 ENOG4107SJS nitrite reductase, (NAD(P)H) HUT12_20205 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding HUT12_20225 ENOG4105CJW magnesium transporter HUT12_20235 ENOG410846T CoA-transferase family III HUT12_20250 ENOG4105EUB pirin domain protein HUT12_20265 ENOG4107R37 Glutamate dehydrogenase HUT12_20275 ENOG4108Z4X TRANSCRIPTIONal HUT12_20310 ENOG4108QV3 biosynthesis protein HUT12_20330 ENOG41067HS methyltransferase HUT12_20335 ENOG4108V75 Glutamine amidotransferase HUT12_20340 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT12_20360 ENOG4107TPY serine threonine protein kinase HUT12_20365 ENOG4107QQG Dehydrogenase HUT12_20380 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_20410 ENOG4105CAQ asparagine synthetase HUT12_20440 ENOG4105BZU Histidine kinase HUT12_20455 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT12_20475 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT12_20495 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT12_20500 ENOG4107QSN dihydrolipoamide acetyltransferase HUT12_20515 ENOG4105EW9 transcriptional regulator AsnC family HUT12_20520 ENOG4105DQE DNA ligase HUT12_20525 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT12_20575 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HUT12_20590 ENOG4108PDG Beta-ketoacyl synthase HUT12_20610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT12_20615 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HUT12_20620 ENOG4105D8K carboxyl transferase HUT12_20625 ENOG4105KTE polyketide synthesis cyclase HUT12_20640 ENOG41061H0 Monooxygenase HUT12_20675 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_20695 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_20705 ENOG4106UW1 Major Facilitator superfamily HUT12_20710 ENOG4105ETE Transcriptional regulator (LacI family HUT12_20800 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT12_20825 ENOG4105ETE Transcriptional regulator (LacI family HUT12_20865 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT12_20870 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT12_20885 ENOG4105DDC Oxidoreductase domain protein HUT12_20895 ENOG4105DIA mandelate racemase muconate lactonizing HUT12_20900 ENOG4105DEI Mannitol dehydrogenase HUT12_20905 ENOG4105CK5 oxidoreductase HUT12_20910 ENOG4108J20 pectate lyase HUT12_20930 ENOG4105BZU Histidine kinase HUT12_20955 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT12_20960 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT12_20975 ENOG4105E3B Multicopper oxidase HUT12_21000 ENOG4106R7G Glycoside hydrolase family 5 HUT12_21010 ENOG4105CPC Aldo Keto reductase HUT12_21015 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_21035 ENOG4105BZU Histidine kinase HUT12_21090 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT12_21115 ENOG4108V0P LemA family HUT12_21140 ENOG4105C57 major facilitator superfamily HUT12_21150 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_21170 ENOG4107RTD sua5 ycio yrdc ywlc family protein HUT12_21200 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUT12_21205 ENOG4105EHG Permease protein HUT12_21215 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT12_21220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_21225 ENOG4105ETE Transcriptional regulator (LacI family HUT12_21240 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_21245 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT12_21255 ENOG4108KGH TRANSCRIPTIONal HUT12_21270 ENOG4105CPK Glycosyl transferase (Group 1 HUT12_21335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_21350 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT12_21390 ENOG4105CYP glycoside hydrolase, family HUT12_21405 ENOG4105GWZ Roadblock lc7 family protein HUT12_21425 ENOG4105CS1 NAD(P)H quinone oxidoreductase HUT12_21440 ENOG4105ENE Histidine kinase HUT12_21450 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_21455 ENOG4107VXZ Hydrolase HUT12_21475 ENOG41082W1 Cupin 2, conserved barrel domain protein HUT12_21485 ENOG4105KBH arsR family transcriptional regulator HUT12_21495 ENOG4105JVQ RNA Polymerase HUT12_21500 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HUT12_21530 ENOG4105E1F short-chain dehydrogenase reductase HUT12_21560 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT12_21600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_21640 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_21725 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT12_21730 ENOG4108Z6Z Transcriptional regulator HUT12_21735 ENOG4105XEA Tetr family transcriptional regulator HUT12_21740 ENOG4105CHR reductase HUT12_21755 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT12_21840 ENOG4105CJ1 ABC, transporter HUT12_21855 ENOG4105C0W non-ribosomal peptide synthetase HUT12_21865 ENOG4107SQU synthase HUT12_21880 ENOG4105C1G acyl-Coa dehydrogenase HUT12_21895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_21960 ENOG4105D9P serine threonine protein kinase HUT12_21975 ENOG4107K5X Membrane-bound metal-dependent hydrolase HUT12_21980 ENOG4105ETE Transcriptional regulator (LacI family HUT12_21995 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_22000 ENOG4105CJQ hydrolase, family 31 HUT12_22025 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT12_22030 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT12_22035 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_22040 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_22055 ENOG4105C2M dna polymerase I HUT12_22060 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT12_22080 ENOG4108SU4 UPF0309 protein HUT12_22085 ENOG4106KNT transcriptional regulator HUT12_22095 ENOG4105RHY Pfam:UPF0157 HUT12_22105 ENOG4105C26 Dehydrogenase HUT12_22110 ENOG4105C8Y Acetylornithine aminotransferase HUT12_22125 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT12_22130 ENOG410783G HUT12_22150 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HUT12_22155 ENOG4105DND Transcriptional regulator HUT12_22180 ENOG4105T0Z Conserved Protein HUT12_22195 ENOG4108JQ7 (ABC) transporter HUT12_22200 ENOG4105C3U ABC transporter HUT12_22205 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_22220 ENOG4105C26 Dehydrogenase HUT12_22230 ENOG4105JSC dimethylmenaquinone methyltransferase HUT12_22250 ENOG4105J4Q Transcriptional regulator HUT12_22260 ENOG4108JQC penicillin-binding protein 1A HUT12_22290 ENOG4108UF8 HUT12_22300 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT12_22305 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT12_22330 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_22365 ENOG4105D7K pfkb domain protein HUT12_22380 ENOG4107T6F Xaa-Pro aminopeptidase HUT12_22440 ENOG4107QM5 aconitate hydratase HUT12_22455 ENOG4105GWZ Roadblock lc7 family protein HUT12_22495 ENOG4108Q5F Tetr family transcriptional regulator HUT12_22505 ENOG4105E18 UPF0276 protein HUT12_22520 ENOG4108VCA G U mismatch-specific DNA glycosylase HUT12_22525 ENOG4105BZ1 (ABC) transporter HUT12_22545 ENOG4105C5H ABC transporter HUT12_22550 ENOG4105CGZ zinc metallopeptidase HUT12_22560 ENOG4107Z1W Fructose transport system kinase HUT12_22575 ENOG4105CNN ABC, transporter HUT12_22580 ENOG4105C2J ABC transporter HUT12_22590 ENOG41080HJ 6-phospho 3-hexuloisomerase HUT12_22600 ENOG4105DEI Mannitol dehydrogenase HUT12_22605 ENOG4105KHC sulfurtransferase HUT12_22620 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_22630 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT12_22635 ENOG4105C9B Cysteine desulfurase HUT12_22640 ENOG4105C3K feS assembly ATPase SufC HUT12_22645 ENOG4105VQD rieske 2fe-2S domain-containing protein HUT12_22680 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT12_22690 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT12_22695 ENOG4105C89 phosphohexose isomerase HUT12_22710 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT12_22725 ENOG4105CP7 Triose-phosphate isomerase HUT12_22730 ENOG4105BZA Phosphoglycerate kinase HUT12_22735 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT12_22740 ENOG4105CIE May be required for sporulation (By similarity) HUT12_22750 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT12_22760 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT12_22765 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT12_22785 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT12_22795 ENOG4105C5X domain protein HUT12_22825 ENOG4107RHI Cytosine-specific methyltransferase HUT12_22895 ENOG4108NF7 phage-type endonuclease HUT12_22980 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT12_23025 ENOG4105CDU Replicative dna helicase HUT12_23125 ENOG4108N0N Phage Terminase Large Subunit HUT12_23745 ENOG4105VEQ Cold shock protein HUT12_23765 ENOG4105EYF MMPL domain protein HUT12_23780 ENOG4105CI3 gtp-binding protein typa HUT12_23790 ENOG4105M2Z protein tyrosine serine phosphatase HUT12_23805 ENOG41061CK Antibiotic biosynthesis monooxygenase HUT12_23825 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT12_23830 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT12_23835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_23850 ENOG4108Z6Z Transcriptional regulator HUT12_23860 ENOG4108IV0 ABC, transporter HUT12_23865 ENOG4105C0Z ABC transporter HUT12_23870 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT12_23875 ENOG4105C32 Amino acid ABC transporter (Permease) HUT12_23880 ENOG4105CP9 extracellular ligand-binding receptor HUT12_23915 ENOG4105DEN Luciferase family HUT12_23920 ENOG4105CX8 fg-gap repeat protein HUT12_23930 ENOG410635A Membrane HUT12_23940 ENOG4105C29 acyl-CoA thioesterase HUT12_23955 ENOG4107S5I aldo keto reductase HUT12_23965 ENOG4105EE5 Membrane protein terC HUT12_24030 ENOG4105CBC glutamate synthase HUT12_24045 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT12_24050 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT12_24055 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT12_24060 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT12_24080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT12_24085 ENOG4105CIG ABC transporter HUT12_24105 ENOG4105BZ1 (ABC) transporter HUT12_24110 ENOG4105BZ1 (ABC) transporter HUT12_24120 ENOG4108X7A Terpene synthase metal-binding domain-containing protein HUT12_24125 ENOG4108IQE Amp-dependent synthetase and ligase HUT12_24135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_24150 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT12_24155 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT12_24165 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT12_24175 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT12_24180 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT12_24185 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT12_24190 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT12_24215 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT12_24245 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT12_24255 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT12_24265 ENOG4105DFU Cell wall formation (By similarity) HUT12_24270 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT12_24280 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT12_24290 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT12_24295 ENOG4105CJN penicillin-binding protein HUT12_24305 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT12_24310 ENOG4108V6E Cell division protein mraZ HUT12_24320 ENOG4105F1K Glutamine amidotransferase HUT12_24330 ENOG4105C8T Leucyl-tRNA synthetase HUT12_24335 ENOG4105KJM monovalent cation h antiporter subunit g HUT12_24350 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_24355 ENOG4108ZE9 Monovalent cation H antiporter subunit C HUT12_24360 ENOG4105D65 subunit l HUT12_24365 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_24375 ENOG4105F8C transglutaminase domain-containing protein HUT12_24385 ENOG4107VJY DNA polymerase HUT12_24400 ENOG4105C0B DNA polymerase III (alpha subunit) HUT12_24420 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT12_24425 ENOG4108ZIP spheroidene monooxygenase HUT12_24475 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT12_24485 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT12_24510 ENOG4108IJ7 Glycine betaine HUT12_24515 ENOG4108HQS Glycine betaine HUT12_24535 ENOG4105D9U N-acetyltransferase HUT12_24555 ENOG4105CTQ phosphohexokinase HUT12_24580 ENOG4105F8J Adenylate Guanylate cyclase HUT12_24595 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT12_24605 ENOG4105H3G oxidoreductase HUT12_24615 ENOG4105DKQ ROK family HUT12_24640 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_24650 ENOG4105BZU Histidine kinase HUT12_24655 ENOG4105JNK Glycosyl transferase (Group 1 HUT12_24660 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HUT12_24675 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT12_24680 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT12_24685 ENOG4108S0S Nucleotidyl transferase HUT12_24700 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT12_24710 ENOG4107UDY cytochrome C HUT12_24730 ENOG4107S1N anthranilate phosphoribosyltransferase HUT12_24740 ENOG4108ZRS Part of cytochrome c oxidase, its function is HUT12_24745 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT12_24750 ENOG4105C3J Cysteine desulfurase HUT12_24775 ENOG4107T4Z adenosine kinase HUT12_24790 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT12_24795 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT12_24810 ENOG4108UMN azlc family HUT12_24815 ENOG4108IMY Transcriptional regulator HUT12_24825 ENOG4105CPC Aldo Keto reductase HUT12_24830 ENOG4107XZ0 Peptidase M50 HUT12_24845 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT12_24850 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HUT12_24860 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT12_24865 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT12_24920 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT12_24940 ENOG4105C5S asparaginyl-tRNA synthetase HUT12_24945 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT12_25015 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUT12_25025 ENOG4105C5F glutamine synthetase HUT12_25030 ENOG41072RD Membrane HUT12_25035 ENOG4107JC6 Membrane HUT12_25045 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT12_25050 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT12_25055 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT12_25065 ENOG4105P3N Membrane HUT12_25070 ENOG4105C5F glutamine synthetase HUT12_25075 ENOG4105C4K Nad synthetase HUT12_25080 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT12_25095 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HUT12_25125 ENOG41086D8 Transcriptional regulator HUT12_25140 ENOG4105FDP GntR family transcriptional regulator HUT12_25195 ENOG4107QZI cell division protein FtsK HUT12_25235 ENOG41089N3 Inherit from COG: cobyrinic Acid a,c-diamide synthase HUT12_25265 ENOG4105EGD dinuclear metal center protein, YbgI family HUT12_25295 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HUT12_25315 ENOG4107XWB Zinc finger, swim domain protein HUT12_25320 ENOG4105C0D helicase HUT12_25350 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT12_25355 ENOG4107YUH hydrolase HUT12_25375 ENOG4105CPP Dehydrogenase, E1 component HUT12_25385 ENOG4107ZED Uncharacterised protein family UPF0047 HUT12_25390 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT12_25415 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_25420 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT12_25445 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT12_25450 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT12_25475 ENOG4108V9Q carbonic anhydrase HUT12_25485 ENOG4105EEM helicase HUT12_25495 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT12_25525 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT12_25530 ENOG41061ZR Transcriptional regulator HUT12_25545 ENOG4105EG6 Saccharopine dehydrogenase HUT12_25550 ENOG4108Z6Z Transcriptional regulator HUT12_25555 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT12_25600 ENOG4105QE3 oxidoreductase HUT12_25615 ENOG4105BZ1 (ABC) transporter HUT12_25635 ENOG4105DVE abc transporter atp-binding protein HUT12_25670 ENOG4105CHP RNA polymerase HUT12_25785 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase HUT12_25810 ENOG4105CNN ABC, transporter HUT12_25815 ENOG4105C2J ABC transporter HUT12_25845 ENOG4105GWZ Roadblock lc7 family protein HUT12_25850 ENOG4105H1G trap transporter solute receptor taxi family HUT12_25880 ENOG4105C94 Transporter HUT12_25890 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT12_25905 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT12_25910 ENOG4105E2D ec 3.2.1.52 HUT12_25930 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT12_25935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT12_25940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT12_25945 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT12_25970 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HUT12_26000 ENOG4108YZG isomerase HUT12_26010 ENOG4105MC2 DSBA oxidoreductase HUT12_26020 ENOG4109057 HUT12_26040 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) HUT12_26055 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_26060 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_26075 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT12_26080 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT12_26085 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HUT12_26110 ENOG4105D8X mechanosensitive ion channel HUT12_26120 ENOG4108Z18 K06886 hemoglobin HUT12_26145 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT12_26150 ENOG4105VNY Trehalose 6-phosphate phosphatase HUT12_26160 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT12_26165 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT12_26180 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT12_26190 ENOG4107QIM DNA ligase HUT12_26200 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT12_26215 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT12_26220 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT12_26225 ENOG4105VHU single-stranded DNA-binding protein HUT12_26265 ENOG4105D8V Glucose sorbosone dehydrogenase HUT12_26280 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_26290 ENOG4105E9Q Acyl-transferase HUT12_26335 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HUT12_26365 ENOG4105XM7 Lipoprotein lprD HUT12_26390 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT12_26395 ENOG4106KNT transcriptional regulator HUT12_26405 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT12_26430 ENOG4105KAV tspo and mbr like protein HUT12_26435 ENOG4105EPJ extracellular solute-binding protein family 1 HUT12_26440 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HUT12_26445 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT12_26450 ENOG4105ETE Transcriptional regulator (LacI family HUT12_26455 ENOG4105CG3 alpha amylase, catalytic region HUT12_26460 ENOG4105CZQ inner membrane transport protein YdhC HUT12_26495 ENOG4105D3Q Sugar transferase HUT12_26545 ENOG41065HY 1,4-beta-cellobiosidase HUT12_26560 ENOG4105C7I Dehydrogenase HUT12_26595 ENOG4105CHU acetyl-coa acetyltransferase HUT12_26645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_26650 ENOG4105Q36 FHA domain containing protein HUT12_26665 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT12_26685 ENOG4105CJ1 ABC, transporter HUT12_26695 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_26700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT12_26715 ENOG4108TCJ secreted hydrolase HUT12_26725 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT12_26735 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT12_26740 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT12_26745 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT12_26750 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT12_26755 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT12_26760 ENOG4106DE0 ATP synthase HUT12_26765 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) HUT12_26780 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT12_26785 ENOG4105CGD Nad-dependent epimerase dehydratase HUT12_26790 ENOG4105BZ4 penicillin-binding protein HUT12_26795 ENOG4105KJF protein tyrosine phosphatase HUT12_26800 ENOG4107UIY sua5 ycio yrdc ywlc family protein HUT12_26805 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT12_26810 ENOG4105BZU Histidine kinase HUT12_26815 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT12_26820 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT12_26830 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT12_26855 ENOG4105YIP Tetr family transcriptional regulator HUT12_26865 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT12_26870 ENOG4105D6E homoserine dehydrogenase HUT12_26875 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT12_26880 ENOG4105C75 arginyL-tRNA synthetase HUT12_26920 ENOG4105DQE DNA ligase HUT12_26935 ENOG4105EYF MMPL domain protein HUT12_26970 ENOG4105CG3 alpha amylase, catalytic region HUT12_26980 ENOG4107T5V SNARE associated Golgi HUT12_26995 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT12_27000 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUT12_27055 ENOG4105CIK Amidinotransferase HUT12_27060 ENOG4105C8Y Acetylornithine aminotransferase HUT12_27070 ENOG410842T Pterin carbinolamine dehydratase HUT12_27095 ENOG4107TPY serine threonine protein kinase HUT12_27110 ENOG4105C0H protease HUT12_27115 ENOG4105BZU Histidine kinase HUT12_27120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_27140 ENOG4105CJ1 ABC, transporter HUT12_27150 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT12_27160 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_27175 ENOG4105C6K Malic enzyme HUT12_27180 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT12_27215 ENOG4108VEQ Superoxide dismutase HUT12_27220 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT12_27230 ENOG4105CBD Diacylglycerol kinase HUT12_27245 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT12_27270 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT12_27285 ENOG4107XI7 Tetr family transcriptional regulator HUT12_27295 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HUT12_27300 ENOG4105WMN AntiSigma factor HUT12_27305 ENOG4105EMN RNA polymerase sigma factor HUT12_27325 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT12_27335 ENOG4107TK4 histidinol-phosphate phosphatase HUT12_27345 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT12_27360 ENOG4105ENE Histidine kinase HUT12_27370 ENOG4105C8V SAICAR synthetase HUT12_27390 ENOG4105DJZ UPF0182 protein HUT12_27395 ENOG41063PX domain protein HUT12_27435 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_27495 ENOG4105VEQ Cold shock protein HUT12_27510 ENOG4108URH decarboxylase HUT12_27515 ENOG4108URH decarboxylase HUT12_27525 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT12_27530 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HUT12_27540 ENOG4108UW5 maltose o-acetyltransferase HUT12_27560 ENOG4105EVN Prephenate dehydrogenase HUT12_27570 ENOG4108Z4U Ferredoxin HUT12_27590 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT12_27615 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT12_27635 ENOG4105KZX Pterin carbinolamine dehydratase HUT12_27645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_27650 ENOG4108UB4 uncharacterized protein ygjQ HUT12_27665 ENOG4105C3G gtp-binding protein HUT12_27680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT12_27685 ENOG4105BZ1 (ABC) transporter HUT12_27690 ENOG4105BZ1 (ABC) transporter HUT12_27695 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT12_27715 ENOG4105DA5 (ABC) transporter HUT12_27725 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) HUT12_27730 ENOG4105N2W Transcriptional regulator HUT12_27760 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT12_27765 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_27770 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_27775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_27780 ENOG4105C3U ABC transporter HUT12_27785 ENOG4108JQ7 (ABC) transporter HUT12_27790 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT12_27825 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT12_27835 ENOG4105DR5 peptidase HUT12_27840 ENOG4105E4C Lytic transglycosylase catalytic HUT12_27850 ENOG4106D2I Chorismate mutase HUT12_27855 ENOG4108JQ7 (ABC) transporter HUT12_27865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_27870 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_27880 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_27885 ENOG4108XG2 Histidine kinase HUT12_27900 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT12_27905 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HUT12_27915 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT12_27925 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT12_27935 ENOG4108KGH TRANSCRIPTIONal HUT12_27945 ENOG4107QVP Dehydrogenase HUT12_27960 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_27965 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_27975 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT12_27980 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT12_28000 ENOG4108Z66 YbaK ebsC protein HUT12_28010 ENOG4105C2J ABC transporter HUT12_28015 ENOG4108HWW ABC transporter HUT12_28040 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT12_28055 ENOG4108MMM RNA Polymerase HUT12_28070 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT12_28075 ENOG4108097 ATP-binding protein HUT12_28085 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT12_28105 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT12_28115 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT12_28120 ENOG4108UJD 30S ribosomal protein S9 HUT12_28125 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT12_28130 ENOG4105DQQ Major facilitator superfamily MFS_1 HUT12_28145 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT12_28150 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT12_28155 ENOG4108IFG nitrite reductase, (NAD(P)H) HUT12_28160 ENOG4107QZF nitrite reductase NADPH large subunit HUT12_28165 ENOG4107QZF nitrite reductase NADPH large subunit HUT12_28185 ENOG4105GWZ Roadblock lc7 family protein HUT12_28200 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_28230 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT12_28240 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT12_28245 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT12_28255 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT12_28270 ENOG4105CPC Aldo Keto reductase HUT12_28280 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HUT12_28290 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT12_28295 ENOG4108ZT0 50S ribosomal protein l17 HUT12_28300 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT12_28305 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT12_28310 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT12_28315 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT12_28320 ENOG41067V7 50S ribosomal protein L36 HUT12_28325 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT12_28340 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT12_28345 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUT12_28350 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT12_28355 ENOG410849U 50S ribosomal protein L30 HUT12_28360 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT12_28365 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT12_28370 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT12_28375 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT12_28380 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT12_28385 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT12_28390 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT12_28395 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT12_28400 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT12_28405 ENOG41082SA 50s ribosomal protein l29 HUT12_28410 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT12_28415 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT12_28420 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT12_28425 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT12_28430 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT12_28435 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT12_28440 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT12_28445 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT12_28450 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT12_28455 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT12_28460 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT12_28465 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT12_28470 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT12_28485 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT12_28490 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT12_28495 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT12_28500 ENOG4108VZM 50s ribosomal protein L10 HUT12_28510 ENOG4105DIK (ABC) transporter HUT12_28515 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT12_28520 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT12_28545 ENOG410900P UPF0336 protein HUT12_28550 ENOG4105WDJ 50S ribosomal protein L33 HUT12_28580 ENOG4108VPT UPF0234 protein HUT12_28585 ENOG4105E1F short-chain dehydrogenase reductase HUT12_28590 ENOG4108JGH Tetr family transcriptional regulator HUT12_28600 ENOG4105D0M Protease HtpX homolog HUT12_28620 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_28625 ENOG4107YX3 NADH dehydrogenase subunit j HUT12_28630 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_28635 ENOG4105CHF Glutathione S-transferase HUT12_28640 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT12_28645 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT12_28650 ENOG4105CPQ Dehydrogenase HUT12_28660 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_28670 ENOG4105CT4 transporter HUT12_28680 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT12_28685 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT12_28735 ENOG4105C1J atp-dependent rna helicase HUT12_28755 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT12_28765 ENOG4105CZN Potassium uptake protein HUT12_28770 ENOG4107ZYR domain protein HUT12_28775 ENOG4107QPV Serine Threonine protein kinase HUT12_28790 ENOG4105ECY inositol monophosphatase HUT12_28800 ENOG4105BZU Histidine kinase HUT12_28805 ENOG4105EEX Two component transcriptional regulator (Winged helix family HUT12_28810 ENOG4105IIU Aminopeptidase HUT12_28835 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT12_28860 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_28870 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT12_28875 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT12_28880 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT12_28885 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT12_28890 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT12_28905 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_28920 ENOG4108RXW HAD-superfamily subfamily IB hydrolase HUT12_28945 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_28950 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_29000 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT12_29020 ENOG4105DSE periplasmic solute binding protein HUT12_29025 ENOG4105DIK (ABC) transporter HUT12_29055 ENOG4108SU4 UPF0309 protein HUT12_29070 ENOG4108PJD permease HUT12_29075 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HUT12_29080 ENOG4108JJB ABC transporter HUT12_29095 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT12_29105 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT12_29110 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT12_29125 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT12_29140 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT12_29155 ENOG4105K59 histidine triad (HIT) protein HUT12_29170 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT12_29175 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT12_29190 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HUT12_29215 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT12_29235 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT12_29250 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT12_29265 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HUT12_29270 ENOG4105KQC Competence protein HUT12_29275 ENOG4105CHR reductase HUT12_29280 ENOG4105EPR degv family HUT12_29285 ENOG4105CVJ phosphoglycerate mutase HUT12_29290 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HUT12_29295 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT12_29315 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT12_29320 ENOG4105K46 50S ribosomal protein l27 HUT12_29325 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT12_29330 ENOG4105C03 ribonuclease HUT12_29350 ENOG4105F6E Acyl-transferase HUT12_29355 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT12_29360 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT12_29365 ENOG4108KPJ rna polymerase sigma factor HUT12_29370 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT12_29385 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT12_29390 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT12_29430 ENOG4106032 Glutathionylspermidine synthase HUT12_29440 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT12_29445 ENOG4107R33 ppx gppa phosphatase HUT12_29450 ENOG4108JWX HUT12_29470 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT12_29495 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT12_29505 ENOG4107R4N Cell wall formation (By similarity) HUT12_29525 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_29535 ENOG4105ETE Transcriptional regulator (LacI family HUT12_29540 ENOG4105KME endoribonuclease L-psp HUT12_29555 ENOG4105DTA methyltransferase HUT12_29580 ENOG4105BZU Histidine kinase HUT12_29585 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_29600 ENOG4105C1J atp-dependent rna helicase HUT12_29650 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT12_29655 ENOG4105I3K Ferric uptake regulator, Fur family HUT12_29665 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT12_29710 ENOG4105PKJ carbohydrate binding HUT12_29715 ENOG4105KHC sulfurtransferase HUT12_29730 ENOG4107NHD transcriptional regulator HUT12_29740 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_29765 ENOG4105CSR polyphosphate kinase 2 HUT12_29795 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HUT12_29815 ENOG4105CQB FAD linked oxidase domain protein HUT12_29845 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT12_29855 ENOG4105VEQ Cold shock protein HUT12_29870 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_29875 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT12_29895 ENOG4105CJ1 ABC, transporter HUT12_29910 ENOG4105GWZ Roadblock lc7 family protein HUT12_29935 ENOG4107TCE N-acetyltransferase HUT12_29955 ENOG4105CJ1 ABC, transporter HUT12_29960 ENOG4105E98 transcriptional regulator DeoR family HUT12_29965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT12_29970 ENOG4105DKQ ROK family HUT12_29975 ENOG4105CE4 GlcNAc 6-P deacetylase HUT12_30015 ENOG4105K64 Glycosyl transferase, family 2 HUT12_30020 ENOG4107T8Q Glycosyl transferase (Group 1 HUT12_30045 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT12_30050 ENOG4105C8N cysteinyl-tRNA synthetase HUT12_30065 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_30085 ENOG4105C9Q fumarate hydratase class II HUT12_30095 ENOG4107GFK fumarate HUT12_30120 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT12_30135 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT12_30170 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT12_30175 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT12_30210 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT12_30225 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUT12_30230 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT12_30240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_30245 ENOG4105VUC UPF0237 protein HUT12_30270 ENOG4105CRK lysyL-tRNA synthetase HUT12_30280 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT12_30290 ENOG4108IYU L-aspartate oxidase HUT12_30300 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT12_30305 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT12_30320 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_30335 ENOG4105E90 ABC transporter HUT12_30340 ENOG4105E90 ABC transporter HUT12_30410 ENOG4105E4C Lytic transglycosylase catalytic HUT12_30435 ENOG4105EUJ GTP cyclohydrolase i HUT12_30440 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT12_30455 ENOG4105ECQ AraC Family Transcriptional Regulator HUT12_30460 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT12_30465 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT12_30480 ENOG4105F0N pyrophosphate phospho-hydrolase HUT12_30490 ENOG4105EC2 ftsk spoIIIe HUT12_30500 ENOG4105YVM Phosphoesterase, PA-phosphatase related HUT12_30510 ENOG4105P8F nudix hydrolase HUT12_30515 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUT12_30520 ENOG4105CSM endonuclease III HUT12_30555 ENOG4105C1G acyl-Coa dehydrogenase HUT12_30560 ENOG4107QX3 carboxylase HUT12_30605 ENOG4105F8J Adenylate Guanylate cyclase HUT12_30610 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT12_30645 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_30650 ENOG4105BZ4 penicillin-binding protein HUT12_30655 ENOG4105KTH gatB Yqey HUT12_30660 ENOG4105DIN metallophosphoesterase HUT12_30690 ENOG4105N14 lysine exporter protein LysE YggA HUT12_30720 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT12_30725 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT12_30740 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT12_30765 ENOG4105BZU Histidine kinase HUT12_30775 ENOG4105CFH Aspartokinase HUT12_30790 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT12_30810 ENOG4108JQ7 (ABC) transporter HUT12_30815 ENOG4105C3U ABC transporter HUT12_30820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_30825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_30830 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_30835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT12_30840 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT12_30930 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HUT12_30945 ENOG4108Z6B deaminase HUT12_30975 ENOG4105DCG PHP domain protein HUT12_30990 ENOG4108M6P methyltransferase HUT12_30995 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HUT12_31005 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HUT12_31125 ENOG4105EC2 ftsk spoIIIe HUT12_31140 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_31165 ENOG4106F1P AAA ATPase, central domain protein HUT12_31220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT12_31250 ENOG4105ECY inositol monophosphatase HUT12_31270 ENOG4105CGH 5'-nucleotidase HUT12_31285 ENOG4105CUX Signal transduction histidine kinase HUT12_31315 ENOG4105XEA Tetr family transcriptional regulator HUT12_31400 ENOG4105EXC Acyl-transferase HUT12_31450 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_31470 ENOG4108V1U phospholipid-binding protein HUT12_31490 ENOG4108Z4X TRANSCRIPTIONal HUT12_31505 ENOG4105CKK Glycosyl transferase, family 2 HUT12_31530 ENOG4105CHU acetyl-coa acetyltransferase HUT12_31555 ENOG4105D7N magnesium and cobalt transport protein CorA HUT12_31560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_31585 ENOG4108MDK Dehydrogenase HUT12_31605 ENOG4105D3Q Sugar transferase HUT12_31610 ENOG4108HRK Histidine kinase HUT12_31670 ENOG4107QN1 sodium solute HUT12_31675 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUT12_31705 ENOG4105BZU Histidine kinase HUT12_31720 ENOG4105CEU Arginine dihydrolase HUT12_31740 ENOG4105CQC Prephenate dehydratase HUT12_31755 ENOG4108Z9K Osmotically inducible protein HUT12_31765 ENOG410667J hydrolase HUT12_31770 ENOG4108KP7 hydrolase HUT12_31775 ENOG4108VC7 Protein of unknown function (DUF2587) HUT12_31790 ENOG4105CIK Amidinotransferase HUT12_31820 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT12_31850 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT12_31860 ENOG4107RN3 metallophosphoesterase HUT12_31905 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUT12_31910 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT12_31920 ENOG4105BZU Histidine kinase HUT12_31940 ENOG4105CDU Replicative dna helicase HUT12_31950 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT12_31955 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT12_31965 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT12_31985 ENOG4105BZ4 penicillin-binding protein HUT12_32000 ENOG4105CZA synthase HUT12_32005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT12_32010 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_32015 ENOG4105DJ0 Poly(A) Polymerase HUT12_32040 ENOG4105C3M thioredoxin reductase HUT12_32045 ENOG4105K63 Thioredoxin HUT12_32050 ENOG4108E1C hydrolase HUT12_32060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_32065 ENOG4105CPF Cell wall formation (By similarity) HUT12_32080 ENOG4107QJE Chromosome Partitioning Protein HUT12_32085 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT12_32095 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT12_32100 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT12_32110 ENOG41084CH 50S ribosomal protein l34 HUT12_32120 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT12_32125 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT12_32130 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT12_32135 ENOG4105K7N UPF0232 protein HUT12_32145 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_32255 ENOG4105DR5 peptidase HUT12_32400 ENOG4107414 GntR family transcriptional regulator HUT12_32445 ENOG4107QZI cell division protein FtsK