locus-tag	class	description
HUT12_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT12_00005	COG1372	Participates in initiation and elongation during chromosome replication
HUT12_00025	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_00035	COG0009	L-threonylcarbamoyladenylate synthase
HUT12_00040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT12_00085	COG0517	IMP dehydrogenase activity
HUT12_00090	COG0442	prolyl-tRNA aminoacylation
HUT12_00095	COG2197	response regulator
HUT12_00100	COG4585	Histidine kinase
HUT12_00115	COG0596	Alpha beta hydrolase
HUT12_00150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_00155	COG0326	Molecular chaperone. Has ATPase activity
HUT12_00170	COG0439	Biotin carboxylase
HUT12_00175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_00180	COG0667	Aldo Keto reductase
HUT12_00215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_00235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT12_00240	COG1960	acyl-CoA dehydrogenase activity
HUT12_00260	COG2353	YceI-like domain
HUT12_00275	COG0515	serine threonine protein kinase
HUT12_00275	COG2815	serine threonine protein kinase
HUT12_00335	COG1716	ATPase activity
HUT12_00335	COG1716	ATPase activity
HUT12_00340	COG1716	ATPase activity
HUT12_00355	COG0768	penicillin binding
HUT12_00360	COG0515	serine threonine protein kinase
HUT12_00365	COG2815	serine threonine protein kinase
HUT12_00365	COG0515	serine threonine protein kinase
HUT12_00405	COG0247	lactate metabolic process
HUT12_00405	COG2181	nitrate reductase activity
HUT12_00410	COG0791	NLP P60 protein
HUT12_00420	COG0717	Belongs to the dCTP deaminase family
HUT12_00450	COG0546	phosphoglycolate phosphatase activity
HUT12_00490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_00505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT12_00510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUT12_00520	COG1960	acyl-CoA dehydrogenase activity
HUT12_00530	COG2062	phosphohistidine phosphatase, SixA
HUT12_00555	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUT12_00575	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_00580	COG0022	dehydrogenase e1 component
HUT12_00625	COG0443	Heat shock 70 kDa protein
HUT12_00630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUT12_00635	COG0484	heat shock protein binding
HUT12_00640	COG0789	Transcriptional regulator
HUT12_00675	COG0542	response to heat
HUT12_00705	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_00715	COG0640	Transcriptional regulator
HUT12_00725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT12_00740	COG1950	PFAM Membrane protein of
HUT12_00745	COG0191	fructose-bisphosphate aldolase activity
HUT12_00770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT12_00785	COG0151	Belongs to the GarS family
HUT12_00820	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_00825	COG1960	acyl-CoA dehydrogenase activity
HUT12_00835	COG1309	transcriptional regulator
HUT12_00845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT12_00865	COG2030	dehydratase
HUT12_00870	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_00875	COG0183	Belongs to the thiolase family
HUT12_00880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT12_00885	COG0393	Putative heavy-metal-binding
HUT12_00895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_00900	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT12_00905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_00930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT12_00935	COG0641	radical SAM
HUT12_00980	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_00985	COG1024	Enoyl-CoA hydratase
HUT12_01035	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT12_01065	COG1609	Transcriptional regulator
HUT12_01070	COG1653	transport
HUT12_01075	COG1175	transmembrane transport
HUT12_01080	COG0395	ABC-type sugar transport system, permease component
HUT12_01085	COG0366	Alpha amylase catalytic
HUT12_01185	COG4585	Histidine kinase
HUT12_01200	COG2197	response regulator
HUT12_01205	COG2091	lysine biosynthetic process via aminoadipic acid
HUT12_01235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_01255	COG3320	Male sterility
HUT12_01255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_01335	COG1116	anion transmembrane transporter activity
HUT12_01350	COG4566	intracellular signal transduction
HUT12_01360	COG3135	benzoate transporter
HUT12_01375	COG1970	mechanosensitive ion channel activity
HUT12_01380	COG2186	Transcriptional regulator
HUT12_01385	COG2807	transmembrane transport
HUT12_01395	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_01400	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_01405	COG2172	sigma factor antagonist activity
HUT12_01415	COG2205	protein histidine kinase activity
HUT12_01420	COG0745	RESPONSE REGULATOR receiver
HUT12_01450	COG1136	(ABC) transporter
HUT12_01465	COG0277	FAD linked oxidase domain protein
HUT12_01490	COG0151	Belongs to the GarS family
HUT12_01525	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_01530	COG1960	acyl-CoA dehydrogenase activity
HUT12_01540	COG1309	transcriptional regulator
HUT12_01550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT12_01570	COG2030	dehydratase
HUT12_01575	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_01580	COG0183	Belongs to the thiolase family
HUT12_01585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT12_01590	COG0393	Putative heavy-metal-binding
HUT12_01600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_01605	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT12_01610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_01635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT12_01640	COG0641	radical SAM
HUT12_01685	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_01690	COG1024	Enoyl-CoA hydratase
HUT12_01740	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT12_01770	COG1609	Transcriptional regulator
HUT12_01775	COG1653	transport
HUT12_01780	COG1175	transmembrane transport
HUT12_01785	COG0395	ABC-type sugar transport system, permease component
HUT12_01790	COG0366	Alpha amylase catalytic
HUT12_01890	COG4585	Histidine kinase
HUT12_01905	COG2197	response regulator
HUT12_01910	COG2091	lysine biosynthetic process via aminoadipic acid
HUT12_01940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_01960	COG3320	Male sterility
HUT12_01960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_02040	COG1116	anion transmembrane transporter activity
HUT12_02055	COG4566	intracellular signal transduction
HUT12_02065	COG3135	benzoate transporter
HUT12_02080	COG1970	mechanosensitive ion channel activity
HUT12_02085	COG2186	Transcriptional regulator
HUT12_02090	COG2807	transmembrane transport
HUT12_02100	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_02105	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_02110	COG2172	sigma factor antagonist activity
HUT12_02120	COG2205	protein histidine kinase activity
HUT12_02125	COG0745	RESPONSE REGULATOR receiver
HUT12_02155	COG1136	(ABC) transporter
HUT12_02170	COG0277	FAD linked oxidase domain protein
HUT12_02180	COG2205	protein histidine kinase activity
HUT12_02180	COG0784	Response regulator, receiver
HUT12_02190	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_02195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT12_02200	COG0406	alpha-ribazole phosphatase activity
HUT12_02205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT12_02210	COG0785	Cytochrome C biogenesis protein
HUT12_02220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUT12_02250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUT12_02265	COG0163	prenyltransferase activity
HUT12_02275	COG1522	sequence-specific DNA binding
HUT12_02280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT12_02290	COG0513	Belongs to the DEAD box helicase family
HUT12_02305	COG0791	NLP P60 protein
HUT12_02310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT12_02330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT12_02335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_02340	COG1120	ATPase activity
HUT12_02355	COG1131	(ABC) transporter
HUT12_02360	COG3973	AAA domain
HUT12_02365	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT12_02380	COG3396	Phenylacetate-CoA oxygenase
HUT12_02385	COG3460	Phenylacetate-CoA oxygenase
HUT12_02390	COG3396	Phenylacetate-CoA oxygenase
HUT12_02395	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT12_02400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT12_02410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT12_02420	COG2226	methyltransferase
HUT12_02440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_02445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_02450	COG0649	NAD binding
HUT12_02465	COG1034	ATP synthesis coupled electron transport
HUT12_02475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_02485	COG0713	ATP synthesis coupled electron transport
HUT12_02500	COG1007	ATP synthesis coupled electron transport
HUT12_02590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT12_02650	COG1674	ftsk spoiiie
HUT12_02745	COG1111	helicase
HUT12_02745	COG1205	dead DEAH box helicase
HUT12_02750	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_02760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUT12_02775	COG1754	DNA topoisomerase type I activity
HUT12_02775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUT12_02785	COG1309	transcriptional regulator
HUT12_02795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT12_02800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUT12_02820	COG1774	PSP1 C-terminal conserved region
HUT12_02860	COG3550	peptidyl-serine autophosphorylation
HUT12_02900	COG0693	protein deglycase activity
HUT12_02915	COG1063	alcohol dehydrogenase
HUT12_02920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_02930	COG0545	Peptidyl-prolyl cis-trans isomerase
HUT12_02935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT12_02940	COG1793	dna ligase
HUT12_02940	COG3285	dna ligase
HUT12_02945	COG1793	dna ligase
HUT12_02945	COG3285	dna ligase
HUT12_02975	COG1061	Type III restriction enzyme res subunit
HUT12_02995	COG1278	Cold shock
HUT12_03000	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT12_03010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT12_03015	COG2814	Major facilitator Superfamily
HUT12_03030	COG2252	PERMEase
HUT12_03040	COG2814	Major facilitator Superfamily
HUT12_03055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUT12_03065	COG0259	pyridoxamine-phosphate oxidase activity
HUT12_03075	COG2017	converts alpha-aldose to the beta-anomer
HUT12_03090	COG1960	acyl-CoA dehydrogenase activity
HUT12_03105	COG1760	l-serine dehydratase
HUT12_03125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT12_03130	COG3842	ATPase activity
HUT12_03230	COG1937	Protein conserved in bacteria
HUT12_03250	COG3237	CsbD-like
HUT12_03265	COG3387	PFAM Glycoside hydrolase 15-related
HUT12_03280	COG1742	UPF0060 membrane protein
HUT12_03290	COG1132	(ABC) transporter
HUT12_03305	COG2837	iron assimilation
HUT12_03335	COG2217	Heavy metal translocating P-type atpase
HUT12_03355	COG1309	transcriptional regulator
HUT12_03360	COG0667	Aldo Keto reductase
HUT12_03370	COG2197	response regulator
HUT12_03380	COG1131	(ABC) transporter
HUT12_03485	COG1674	ftsk spoiiie
HUT12_03490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT12_03520	COG1404	Belongs to the peptidase S8 family
HUT12_03525	COG0464	growth
HUT12_03545	COG0702	epimerase
HUT12_03555	COG0740	serine-type endopeptidase activity
HUT12_03565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT12_03570	COG1846	Transcriptional regulator
HUT12_03575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT12_03580	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT12_03585	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT12_03585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT12_03590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_03595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT12_03620	COG0519	Catalyzes the synthesis of GMP from XMP
HUT12_03630	COG1024	Enoyl-CoA hydratase
HUT12_03645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT12_03650	COG4122	O-methyltransferase activity
HUT12_03655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_03660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT12_03675	COG2239	Acts as a magnesium transporter
HUT12_03680	COG0384	phenazine biosynthesis protein PhzF
HUT12_03745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT12_03775	COG1595	DNA-templated transcription, initiation
HUT12_03785	COG0613	PHP domain protein
HUT12_03790	COG2095	MarC family integral membrane protein
HUT12_03830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT12_03840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT12_03845	COG0303	'Molybdopterin
HUT12_03865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT12_03875	COG0640	Transcriptional regulator
HUT12_03910	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_03915	COG1196	nuclear chromosome segregation
HUT12_03915	COG0741	lytic transglycosylase activity
HUT12_03915	COG0739	heme binding
HUT12_03940	COG3940	Belongs to the glycosyl hydrolase 43 family
HUT12_03990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT12_03995	COG2267	carboxylic ester hydrolase activity
HUT12_04005	COG0084	hydrolase, TatD family'
HUT12_04010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT12_04015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUT12_04020	COG0488	(ABC) transporter
HUT12_04055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT12_04060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT12_04065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUT12_04070	COG0193	aminoacyl-tRNA hydrolase activity
HUT12_04075	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUT12_04090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUT12_04095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT12_04105	COG0180	Tryptophanyl-tRNA synthetase
HUT12_04125	COG0366	Alpha amylase catalytic
HUT12_04145	COG3833	ABC-type maltose transport systems, permease component
HUT12_04195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT12_04210	COG2018	Roadblock/LC7 domain
HUT12_04235	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUT12_04240	COG4988	ABC transporter
HUT12_04255	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_04260	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_04265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUT12_04270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUT12_04290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT12_04300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_04300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_04305	COG1473	amidohydrolase
HUT12_04305	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT12_04370	COG4770	biotin carboxylase activity
HUT12_04390	COG0424	maF-like protein
HUT12_04395	COG1404	Belongs to the peptidase S8 family
HUT12_04435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT12_04460	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUT12_04470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT12_04475	COG1877	trehalose-phosphatase activity
HUT12_04475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_04500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUT12_04535	COG1722	exodeoxyribonuclease VII activity
HUT12_04540	COG1570	exodeoxyribonuclease VII activity
HUT12_04545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT12_04560	COG1322	Protein conserved in bacteria
HUT12_04570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUT12_04620	COG0148	phosphopyruvate hydratase activity
HUT12_04635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT12_04665	COG0714	Associated with various cellular activities
HUT12_04705	COG0183	Belongs to the thiolase family
HUT12_04735	COG0456	acetyltransferase
HUT12_04735	COG0454	-acetyltransferase
HUT12_04740	COG1234	tRNA 3'-trailer cleavage
HUT12_04745	COG1363	Peptidase, m42
HUT12_04750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT12_04750	COG0189	ligase activity
HUT12_04755	COG0367	asparagine synthase
HUT12_04760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT12_04765	COG0537	adenosine 5'-monophosphoramidase activity
HUT12_04790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT12_04795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT12_04805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT12_04820	COG1331	Highly conserved protein containing a thioredoxin domain
HUT12_04840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT12_04865	COG3845	ABC transporter
HUT12_05000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT12_05030	COG4762	Protein conserved in bacteria
HUT12_05055	COG4974	Belongs to the 'phage' integrase family
HUT12_05250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_05265	COG1902	pentaerythritol trinitrate reductase activity
HUT12_05280	COG0604	alcohol dehydrogenase
HUT12_05285	COG3903	Transcriptional regulator
HUT12_05285	COG3629	intracellular signal transduction
HUT12_05300	COG0477	Major facilitator Superfamily
HUT12_05310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_05330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_05335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_05350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT12_05360	COG1126	abc transporter atp-binding protein
HUT12_05365	COG0765	amino acid transport
HUT12_05370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_05395	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_05425	COG0747	negative chemotaxis
HUT12_05445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_05460	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_05465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_05470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_05480	COG1960	acyl-CoA dehydrogenase activity
HUT12_05485	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_05510	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_05515	COG0183	Belongs to the thiolase family
HUT12_05530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_05545	COG0747	negative chemotaxis
HUT12_05550	COG1024	Enoyl-CoA hydratase
HUT12_05590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT12_05635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT12_05675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_05700	COG3842	ATPase activity
HUT12_05705	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT12_05710	COG1177	transmembrane transport
HUT12_05725	COG0010	Belongs to the arginase family
HUT12_05735	COG0745	RESPONSE REGULATOR receiver
HUT12_05740	COG2205	protein histidine kinase activity
HUT12_05750	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT12_05775	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_05790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT12_05795	COG2835	tetraacyldisaccharide 4'-kinase activity
HUT12_05815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT12_05840	COG0714	Associated with various cellular activities
HUT12_05860	COG0745	RESPONSE REGULATOR receiver
HUT12_05880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUT12_05885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT12_05895	COG0653	protein targeting
HUT12_05920	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUT12_05920	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUT12_05920	COG0506	proline dehydrogenase activity
HUT12_05930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT12_05935	COG2884	Cell division ATP-binding protein ftsE
HUT12_05940	COG2177	Part of the ABC transporter FtsEX involved in
HUT12_05945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT12_05965	COG1678	Uncharacterized ACR, COG1678
HUT12_06080	COG2070	2-Nitropropane dioxygenase
HUT12_06085	COG2814	Major facilitator Superfamily
HUT12_06095	COG1024	Enoyl-CoA hydratase
HUT12_06105	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_06115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_06130	COG1024	Enoyl-CoA hydratase
HUT12_06135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_06140	COG2186	Transcriptional regulator
HUT12_06155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_06190	COG1960	acyl-CoA dehydrogenase activity
HUT12_06195	COG2301	Belongs to the HpcH HpaI aldolase family
HUT12_06210	COG1960	acyl-CoA dehydrogenase activity
HUT12_06225	COG3591	Belongs to the peptidase S1B family
HUT12_06230	COG0475	glutathione-regulated potassium exporter activity
HUT12_06240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_06260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_06300	COG3251	PFAM MbtH domain protein
HUT12_06310	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_06350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT12_06355	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_06355	COG0022	dehydrogenase e1 component
HUT12_06360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_06385	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HUT12_06410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT12_06465	COG0789	Transcriptional regulator
HUT12_06490	COG2814	Major facilitator Superfamily
HUT12_06510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT12_06590	COG0477	Major facilitator Superfamily
HUT12_06615	COG0656	L-ascorbic acid biosynthetic process
HUT12_06625	COG1192	Involved in chromosome partitioning
HUT12_06640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT12_06685	COG4585	Histidine kinase
HUT12_06690	COG2197	response regulator
HUT12_06715	COG2234	aminopeptidase activity
HUT12_06765	COG2205	protein histidine kinase activity
HUT12_06770	COG0745	RESPONSE REGULATOR receiver
HUT12_06800	COG3387	PFAM Glycoside hydrolase 15-related
HUT12_06815	COG0656	L-ascorbic acid biosynthetic process
HUT12_06825	COG4733	cellulase activity
HUT12_06825	COG5297	Belongs to the glycosyl hydrolase family 6
HUT12_06830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_06835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT12_06845	COG1335	isochorismatase
HUT12_06850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUT12_06855	COG2197	response regulator
HUT12_06865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUT12_06890	COG1234	tRNA 3'-trailer cleavage
HUT12_06900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUT12_06905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUT12_06910	COG2986	histidine ammonia-lyase
HUT12_06915	COG1228	amidohydrolase
HUT12_06925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_06930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUT12_06945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT12_06945	COG2755	lipolytic protein G-D-S-L family
HUT12_06980	COG1316	TRANSCRIPTIONal
HUT12_07030	COG1122	ATPase activity
HUT12_07075	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUT12_07085	COG0477	Major facilitator Superfamily
HUT12_07090	COG3226	Transcriptional regulator
HUT12_07095	COG1376	ErfK ybiS ycfS ynhG family protein
HUT12_07100	COG1376	ErfK ybiS ycfS ynhG family protein
HUT12_07110	COG2409	Drug exporters of the RND superfamily
HUT12_07120	COG0667	Aldo Keto reductase
HUT12_07130	COG0501	Belongs to the peptidase M48B family
HUT12_07160	COG2205	protein histidine kinase activity
HUT12_07235	COG1131	(ABC) transporter
HUT12_07240	COG1119	ATPase activity
HUT12_07245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_07295	COG2149	membrane
HUT12_07315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUT12_07325	COG1595	DNA-templated transcription, initiation
HUT12_07345	COG0482	sulfurtransferase activity
HUT12_07365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT12_07375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT12_07380	COG0154	amidase activity
HUT12_07390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT12_07395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT12_07405	COG2133	pyrroloquinoline quinone binding
HUT12_07425	COG1609	Transcriptional regulator
HUT12_07515	COG0129	dihydroxy-acid dehydratase activity
HUT12_07520	COG5001	Diguanylate cyclase
HUT12_07520	COG3300	MHYT domain
HUT12_07530	COG0440	acetolactate synthase activity
HUT12_07535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT12_07540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT12_07555	COG0473	3-isopropylmalate dehydrogenase activity
HUT12_07560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT12_07575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_07590	COG0714	Associated with various cellular activities
HUT12_07600	COG2304	oxidoreductase activity
HUT12_07605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_07615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT12_07655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT12_07660	COG0066	3-isopropylmalate dehydratase activity
HUT12_07665	COG0776	regulation of translation
HUT12_07680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUT12_07690	COG1920	GTP binding
HUT12_07700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT12_07705	COG0626	cystathionine gamma-synthase activity
HUT12_07710	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT12_07715	COG1940	carbohydrate kinase activity
HUT12_07775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT12_07780	COG1461	Dihydroxyacetone kinase
HUT12_07795	COG0742	ribosomal rna small subunit methyltransferase
HUT12_07800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUT12_07815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUT12_07820	COG0416	fatty acid biosynthetic process
HUT12_07825	COG0571	ribonuclease III activity
HUT12_07830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT12_07840	COG2340	Cysteine-rich secretory protein family
HUT12_07885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT12_07920	COG0442	prolyl-tRNA aminoacylation
HUT12_07930	COG0228	four-way junction DNA binding
HUT12_07935	COG1837	Belongs to the UPF0109 family
HUT12_07940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUT12_07945	COG0336	Belongs to the RNA methyltransferase TrmD family
HUT12_07950	COG0335	large ribosomal subunit rRNA binding
HUT12_07955	COG0681	Belongs to the peptidase S26 family
HUT12_07960	COG0681	Belongs to the peptidase S26 family
HUT12_07970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT12_07995	COG4974	Belongs to the 'phage' integrase family
HUT12_08010	COG0792	nuclease activity
HUT12_08020	COG0052	Belongs to the universal ribosomal protein uS2 family
HUT12_08025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUT12_08030	COG0528	UMP kinase activity
HUT12_08035	COG0233	cytoplasmic translational termination
HUT12_08040	COG0575	Belongs to the CDS family
HUT12_08045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUT12_08060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT12_08060	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_08085	COG1515	deoxyribonuclease V activity
HUT12_08095	COG0750	zinc metalloprotease
HUT12_08100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT12_08120	COG1902	pentaerythritol trinitrate reductase activity
HUT12_08130	COG0435	Glutathione S-transferase
HUT12_08135	COG0183	Belongs to the thiolase family
HUT12_08145	COG5001	Diguanylate cyclase
HUT12_08160	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_08205	COG0577	efflux transmembrane transporter activity
HUT12_08205	COG1136	(ABC) transporter
HUT12_08225	COG0779	Required for maturation of 30S ribosomal subunits
HUT12_08240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUT12_08250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUT12_08255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUT12_08280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUT12_08290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUT12_08295	COG1185	polyribonucleotide nucleotidyltransferase activity
HUT12_08300	COG0612	Peptidase, M16
HUT12_08305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT12_08310	COG1247	-acetyltransferase
HUT12_08325	COG3214	Protein conserved in bacteria
HUT12_08335	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUT12_08340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT12_08345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT12_08365	COG1674	ftsk spoiiie
HUT12_08385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT12_08395	COG1058	Belongs to the CinA family
HUT12_08395	COG1546	Belongs to the CinA family
HUT12_08400	COG1396	sequence-specific DNA binding
HUT12_08415	COG1609	Transcriptional regulator
HUT12_08420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT12_08435	COG0006	proline dipeptidase activity
HUT12_08440	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_08450	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT12_08460	COG3842	ATPase activity
HUT12_08465	COG2132	Multicopper oxidase
HUT12_08470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT12_08495	COG1201	RNA secondary structure unwinding
HUT12_08505	COG2111	Na H antiporter
HUT12_08505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_08525	COG2212	antiporter activity
HUT12_08530	COG1320	monovalent cation:proton antiporter activity
HUT12_08545	COG1253	flavin adenine dinucleotide binding
HUT12_08550	COG4326	sporulation control protein
HUT12_08570	COG1573	uracil-dna glycosylase
HUT12_08575	COG0477	Major facilitator Superfamily
HUT12_08585	COG1372	Participates in initiation and elongation during chromosome replication
HUT12_08585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUT12_08590	COG2137	regulation of response to DNA damage stimulus
HUT12_08595	COG1418	mRNA catabolic process
HUT12_08600	COG0765	amino acid transport
HUT12_08605	COG0765	amino acid transport
HUT12_08610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_08615	COG1126	abc transporter atp-binding protein
HUT12_08635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT12_08640	COG3866	Pectate lyase
HUT12_08645	COG1196	nuclear chromosome segregation
HUT12_08655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUT12_08660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUT12_08670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUT12_08685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUT12_08690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT12_08730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT12_08740	COG1490	D-aminoacyl-tRNA deacylase activity
HUT12_08745	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT12_08755	COG3842	ATPase activity
HUT12_08760	COG1178	ABC-type Fe3 transport system permease component
HUT12_08765	COG1840	ABC-type Fe3 transport system, periplasmic component
HUT12_08785	COG2313	pseudouridylate synthase activity
HUT12_08795	COG2860	membrane
HUT12_08840	COG0756	dUTP diphosphatase activity
HUT12_08865	COG0569	domain protein
HUT12_08870	COG0531	amino acid
HUT12_08875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT12_08880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT12_08900	COG1802	Transcriptional regulator
HUT12_08910	COG1335	isochorismatase
HUT12_08940	COG0745	RESPONSE REGULATOR receiver
HUT12_08945	COG2205	protein histidine kinase activity
HUT12_08965	COG0183	Belongs to the thiolase family
HUT12_08970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUT12_08980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUT12_09020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT12_09040	COG1793	dna ligase
HUT12_09055	COG0438	transferase activity, transferring glycosyl groups
HUT12_09060	COG1442	glycosyl transferase family 8
HUT12_09060	COG1216	Glycosyl transferase, family 2
HUT12_09065	COG0438	transferase activity, transferring glycosyl groups
HUT12_09095	COG0419	ATPase involved in DNA repair
HUT12_09100	COG0420	3'-5' exonuclease activity
HUT12_09130	COG1175	transmembrane transport
HUT12_09135	COG0395	ABC-type sugar transport system, permease component
HUT12_09155	COG1960	acyl-CoA dehydrogenase activity
HUT12_09220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUT12_09225	COG0156	8-amino-7-oxononanoate synthase activity
HUT12_09230	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUT12_09365	COG0464	growth
HUT12_09380	COG2197	response regulator
HUT12_09425	COG0726	polysaccharide deacetylase
HUT12_09440	COG1609	Transcriptional regulator
HUT12_09480	COG0589	response to stress
HUT12_09500	COG0542	response to heat
HUT12_09505	COG1803	Methylglyoxal synthase
HUT12_09505	COG1597	lipid kinase activity
HUT12_09515	COG0671	phosphoesterase, PA-phosphatase related
HUT12_09530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_09540	COG4326	sporulation control protein
HUT12_09555	COG3973	AAA domain
HUT12_09580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_09665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_09710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_09725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT12_09725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT12_09735	COG3304	Inner membrane component domain
HUT12_09775	COG1120	ATPase activity
HUT12_09800	COG1063	alcohol dehydrogenase
HUT12_09820	COG0187	DNA topoisomerase II activity
HUT12_09825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT12_09835	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HUT12_09850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUT12_09855	COG1086	Polysaccharide biosynthesis protein
HUT12_09875	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_09885	COG2089	acid synthase
HUT12_09890	COG1216	Glycosyl transferase, family 2
HUT12_09930	COG1134	teichoic acid transport
HUT12_09930	COG1388	LysM domain
HUT12_09940	COG1309	transcriptional regulator
HUT12_09965	COG5002	protein histidine kinase activity
HUT12_09970	COG2358	TRAP transporter, solute receptor (TAXI family
HUT12_09980	COG3022	response to hydroperoxide
HUT12_10000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUT12_10005	COG0366	Alpha amylase catalytic
HUT12_10020	COG0297	glycogen (starch) synthase activity
HUT12_10025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUT12_10035	COG1086	Polysaccharide biosynthesis protein
HUT12_10040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT12_10045	COG0438	transferase activity, transferring glycosyl groups
HUT12_10065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUT12_10075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUT12_10110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_10120	COG0438	transferase activity, transferring glycosyl groups
HUT12_10140	COG1086	Polysaccharide biosynthesis protein
HUT12_10145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT12_10165	COG2183	response to ionizing radiation
HUT12_10170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT12_10190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT12_10195	COG1053	succinate dehydrogenase
HUT12_10205	COG0583	DNA-binding transcription factor activity
HUT12_10210	COG1643	Atp-dependent helicase
HUT12_10235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUT12_10255	COG0708	Exodeoxyribonuclease III
HUT12_10285	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_10290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_10310	COG1643	Atp-dependent helicase
HUT12_10330	COG0531	amino acid
HUT12_10360	COG1741	Belongs to the pirin family
HUT12_10375	COG1233	COG1233 Phytoene dehydrogenase and related
HUT12_10420	COG1295	ribonuclease BN
HUT12_10440	COG0463	Glycosyl transferase, family 2
HUT12_10450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUT12_10460	COG0297	glycogen (starch) synthase activity
HUT12_10465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT12_10470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT12_10470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT12_10515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_10520	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_10560	COG1278	Cold shock
HUT12_10570	COG0667	Aldo Keto reductase
HUT12_10575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT12_10580	COG2205	protein histidine kinase activity
HUT12_10595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT12_10615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUT12_10620	COG1560	Kdo2-lipid A biosynthetic process
HUT12_10625	COG0438	transferase activity, transferring glycosyl groups
HUT12_10635	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUT12_10640	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUT12_10660	COG0217	transcriptional regulatory protein
HUT12_10705	COG4152	abc transporter atp-binding protein
HUT12_10710	COG2197	response regulator
HUT12_10715	COG4585	Histidine kinase
HUT12_10720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT12_10725	COG0501	Belongs to the peptidase M48B family
HUT12_10730	COG1704	LemA family
HUT12_10745	COG0587	DNA-directed DNA polymerase activity
HUT12_10765	COG0477	Major facilitator Superfamily
HUT12_10770	COG1309	transcriptional regulator
HUT12_10775	COG0586	Pfam SNARE associated Golgi protein
HUT12_10780	COG0387	Pfam Sodium calcium exchanger
HUT12_10785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUT12_10790	COG0632	four-way junction helicase activity
HUT12_10795	COG2255	four-way junction helicase activity
HUT12_10800	COG1862	Preprotein translocase
HUT12_10815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT12_10820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT12_10825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUT12_10840	COG0124	histidyl-tRNA synthetase
HUT12_10865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUT12_10885	COG0456	acetyltransferase
HUT12_10920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT12_10925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUT12_10935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUT12_10955	COG0110	maltose O-acetyltransferase activity
HUT12_11000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT12_11005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT12_11010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT12_11015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUT12_11020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUT12_11025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUT12_11035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUT12_11040	COG0540	Belongs to the ATCase OTCase family
HUT12_11045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT12_11050	COG0505	Belongs to the CarA family
HUT12_11060	COG0167	dihydroorotate dehydrogenase activity
HUT12_11065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_11070	COG0284	orotidine-5'-phosphate decarboxylase activity
HUT12_11080	COG0194	GDP metabolic process
HUT12_11085	COG1758	RNA polymerase activity
HUT12_11095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_11100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_11110	COG1102	Psort location Cytoplasmic, score
HUT12_11115	COG2124	cytochrome p450
HUT12_11120	COG0242	peptide deformylase activity
HUT12_11125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUT12_11150	COG0745	RESPONSE REGULATOR receiver
HUT12_11165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT12_11165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT12_11170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUT12_11195	COG1126	abc transporter atp-binding protein
HUT12_11200	COG0765	amino acid transport
HUT12_11205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_11210	COG0140	phosphoribosyl-ATP diphosphatase activity
HUT12_11215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUT12_11230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUT12_11235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUT12_11240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUT12_11245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT12_11250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUT12_11255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT12_11255	COG0072	phenylalanine-tRNA ligase activity
HUT12_11260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_11280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUT12_11290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT12_11295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUT12_11300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUT12_11305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT12_11310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_11315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT12_11325	COG0165	Argininosuccinate lyase
HUT12_11335	COG2094	Belongs to the DNA glycosylase MPG family
HUT12_11345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUT12_11355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_11365	COG0589	response to stress
HUT12_11385	COG1253	flavin adenine dinucleotide binding
HUT12_11400	COG1914	H( )-stimulated, divalent metal cation uptake system
HUT12_11410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUT12_11435	COG0647	UMP catabolic process
HUT12_11460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT12_11465	COG0497	DNA recombination
HUT12_11490	COG0297	glycogen (starch) synthase activity
HUT12_11500	COG0504	CTP synthase activity
HUT12_11505	COG0494	nUDIX hydrolase
HUT12_11535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUT12_11540	COG1187	pseudouridine synthase activity
HUT12_11550	COG1160	GTP binding
HUT12_11570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT12_11585	COG1309	transcriptional regulator
HUT12_11590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT12_11605	COG1863	multisubunit Na H antiporter MnhE subunit
HUT12_11620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_11620	COG2111	Na H antiporter
HUT12_11630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUT12_11635	COG3559	Exporter of polyketide antibiotics
HUT12_11640	COG1131	(ABC) transporter
HUT12_11645	COG1309	transcriptional regulator
HUT12_11655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_11665	COG3411	Ferredoxin
HUT12_11685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT12_11690	COG0367	asparagine synthase
HUT12_11695	COG0174	glutamine synthetase
HUT12_11810	COG4585	Histidine kinase
HUT12_11815	COG2197	response regulator
HUT12_11895	COG0076	glutamate decarboxylase activity
HUT12_11955	COG1215	transferase activity, transferring glycosyl groups
HUT12_11970	COG0346	lactoylglutathione lyase activity
HUT12_11995	COG1595	DNA-templated transcription, initiation
HUT12_12030	COG1940	carbohydrate kinase activity
HUT12_12045	COG1595	DNA-templated transcription, initiation
HUT12_12055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_12060	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_12065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT12_12120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_12125	COG1129	ABC transporter
HUT12_12150	COG3971	2-oxopent-4-enoate hydratase activity
HUT12_12155	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HUT12_12160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_12185	COG3384	dioxygenase
HUT12_12210	COG0252	asparaginase activity
HUT12_12240	COG4691	Plasmid stability protein
HUT12_12245	COG1487	ribonuclease activity
HUT12_12270	COG1136	(ABC) transporter
HUT12_12270	COG0577	efflux transmembrane transporter activity
HUT12_12275	COG1136	(ABC) transporter
HUT12_12285	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_12295	COG2986	histidine ammonia-lyase
HUT12_12315	COG0475	glutathione-regulated potassium exporter activity
HUT12_12320	COG0745	RESPONSE REGULATOR receiver
HUT12_12325	COG2205	protein histidine kinase activity
HUT12_12335	COG3896	Chloramphenicol phosphotransferase-like protein
HUT12_12340	COG1733	regulation of RNA biosynthetic process
HUT12_12370	COG2267	carboxylic ester hydrolase activity
HUT12_12415	COG0667	Aldo Keto reductase
HUT12_12440	COG0747	negative chemotaxis
HUT12_12465	COG4106	trans-aconitate 2-methyltransferase activity
HUT12_12490	COG1053	succinate dehydrogenase
HUT12_12490	COG3976	FMN-binding domain protein
HUT12_12490	COG0431	NADPH-dependent FMN reductase
HUT12_12495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_12500	COG1335	isochorismatase
HUT12_12515	COG0444	Belongs to the ABC transporter superfamily
HUT12_12520	COG4608	Belongs to the ABC transporter superfamily
HUT12_12525	COG1802	Transcriptional regulator
HUT12_12540	COG1733	regulation of RNA biosynthetic process
HUT12_12565	COG2197	response regulator
HUT12_12570	COG0736	holo-[acyl-carrier-protein] synthase activity
HUT12_12575	COG1960	acyl-CoA dehydrogenase activity
HUT12_12660	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_12725	COG0477	Major facilitator Superfamily
HUT12_12750	COG1960	acyl-CoA dehydrogenase activity
HUT12_12755	COG1414	Transcriptional regulator
HUT12_12760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_12765	COG0183	Belongs to the thiolase family
HUT12_12800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT12_12805	COG0022	dehydrogenase e1 component
HUT12_12805	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_12815	COG0028	Belongs to the TPP enzyme family
HUT12_12820	COG1404	Belongs to the peptidase S8 family
HUT12_12840	COG1404	Belongs to the peptidase S8 family
HUT12_12845	COG1674	ftsk spoiiie
HUT12_12935	COG0714	Associated with various cellular activities
HUT12_12960	COG0789	Transcriptional regulator
HUT12_12980	COG3693	PFAM glycoside hydrolase, family 10
HUT12_13025	COG5002	protein histidine kinase activity
HUT12_13030	COG0745	RESPONSE REGULATOR receiver
HUT12_13040	COG0577	efflux transmembrane transporter activity
HUT12_13040	COG1136	(ABC) transporter
HUT12_13045	COG1136	(ABC) transporter
HUT12_13045	COG0577	efflux transmembrane transporter activity
HUT12_13075	COG0402	S-adenosylhomocysteine deaminase activity
HUT12_13105	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_13115	COG1309	transcriptional regulator
HUT12_13120	COG2409	Drug exporters of the RND superfamily
HUT12_13130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_13190	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_13225	COG2226	methyltransferase
HUT12_13250	COG2197	response regulator
HUT12_13260	COG1131	(ABC) transporter
HUT12_13305	COG1132	(ABC) transporter
HUT12_13320	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUT12_13325	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HUT12_13350	COG1834	amidinotransferase
HUT12_13385	COG1122	ATPase activity
HUT12_13395	COG0561	phosphatase activity
HUT12_13415	COG3119	arylsulfatase activity
HUT12_13420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_13435	COG0028	Belongs to the TPP enzyme family
HUT12_13475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT12_13525	COG3629	intracellular signal transduction
HUT12_13525	COG3903	Transcriptional regulator
HUT12_13560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_13565	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HUT12_13585	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HUT12_13605	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HUT12_13610	COG1414	Transcriptional regulator
HUT12_13615	COG0028	Belongs to the TPP enzyme family
HUT12_13620	COG1024	Enoyl-CoA hydratase
HUT12_13630	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_13655	COG2030	dehydratase
HUT12_13660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT12_13665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT12_13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_13740	COG0765	amino acid transport
HUT12_13775	COG4585	Histidine kinase
HUT12_13780	COG2197	response regulator
HUT12_13790	COG0640	Transcriptional regulator
HUT12_13805	COG0583	DNA-binding transcription factor activity
HUT12_13835	COG0778	Nitroreductase
HUT12_13865	COG2318	DinB family
HUT12_13905	COG1404	Belongs to the peptidase S8 family
HUT12_13915	COG3226	Transcriptional regulator
HUT12_13970	COG0640	Transcriptional regulator
HUT12_13980	COG3629	intracellular signal transduction
HUT12_13980	COG3903	Transcriptional regulator
HUT12_13985	COG3591	Belongs to the peptidase S1B family
HUT12_13990	COG0247	lactate metabolic process
HUT12_13995	COG1139	Iron-sulfur cluster binding protein
HUT12_14000	COG1556	Lactate utilization protein
HUT12_14020	COG0183	Belongs to the thiolase family
HUT12_14025	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_14035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_14050	COG1960	acyl-CoA dehydrogenase activity
HUT12_14055	COG2368	4-hydroxyphenylacetate
HUT12_14060	COG1960	acyl-CoA dehydrogenase activity
HUT12_14065	COG1024	Enoyl-CoA hydratase
HUT12_14075	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_14080	COG1024	Enoyl-CoA hydratase
HUT12_14085	COG1309	transcriptional regulator
HUT12_14090	COG0583	DNA-binding transcription factor activity
HUT12_14100	COG1116	anion transmembrane transporter activity
HUT12_14105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_14110	COG1960	acyl-CoA dehydrogenase activity
HUT12_14120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_14175	COG1252	NADH dehydrogenase
HUT12_14185	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUT12_14195	COG2372	response to copper ion
HUT12_14195	COG1276	copper resistance
HUT12_14225	COG1070	Carbohydrate kinase
HUT12_14235	COG0395	ABC-type sugar transport system, permease component
HUT12_14245	COG1653	transport
HUT12_14260	COG1802	Transcriptional regulator
HUT12_14270	COG0714	Associated with various cellular activities
HUT12_14275	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUT12_14335	COG3693	PFAM glycoside hydrolase, family 10
HUT12_14350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_14365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT12_14370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT12_14375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT12_14390	COG1473	amidohydrolase
HUT12_14395	COG0673	inositol 2-dehydrogenase activity
HUT12_14400	COG1653	transport
HUT12_14405	COG1175	transmembrane transport
HUT12_14410	COG0395	ABC-type sugar transport system, permease component
HUT12_14415	COG3254	rhamnose metabolic process
HUT12_14420	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_14425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT12_14455	COG0640	Transcriptional regulator
HUT12_14460	COG0346	lactoylglutathione lyase activity
HUT12_14475	COG0300	oxidoreductase activity
HUT12_14490	COG4585	Histidine kinase
HUT12_14495	COG2197	response regulator
HUT12_14510	COG0604	alcohol dehydrogenase
HUT12_14510	COG3321	synthase
HUT12_14510	COG0604	alcohol dehydrogenase
HUT12_14510	COG3321	synthase
HUT12_14525	COG0477	Major facilitator Superfamily
HUT12_14540	COG1309	transcriptional regulator
HUT12_14555	COG1228	amidohydrolase
HUT12_14585	COG1396	sequence-specific DNA binding
HUT12_14595	COG1124	(ABC) transporter
HUT12_14600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_14625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT12_14635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT12_14675	COG1175	transmembrane transport
HUT12_14680	COG0395	ABC-type sugar transport system, permease component
HUT12_14685	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_14695	COG1129	ABC transporter
HUT12_14700	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_14705	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_14710	COG4213	ABC transporter substrate-binding protein
HUT12_14750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_14765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUT12_14790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_14800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_14810	COG1920	GTP binding
HUT12_14835	COG2186	Transcriptional regulator
HUT12_14860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT12_14870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT12_14895	COG1228	amidohydrolase
HUT12_14920	COG3903	Transcriptional regulator
HUT12_14920	COG3629	intracellular signal transduction
HUT12_14930	COG3842	ATPase activity
HUT12_14935	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT12_14940	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_14955	COG1609	Transcriptional regulator
HUT12_14965	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_14970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUT12_14975	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_14980	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HUT12_14985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT12_14995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUT12_15005	COG0402	S-adenosylhomocysteine deaminase activity
HUT12_15010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT12_15030	COG1175	transmembrane transport
HUT12_15040	COG1070	Carbohydrate kinase
HUT12_15045	COG1063	alcohol dehydrogenase
HUT12_15050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUT12_15090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_15125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT12_15130	COG0583	DNA-binding transcription factor activity
HUT12_15135	COG0596	Alpha beta hydrolase
HUT12_15150	COG4585	Histidine kinase
HUT12_15155	COG2197	response regulator
HUT12_15165	COG0443	Heat shock 70 kDa protein
HUT12_15190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_15220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_15225	COG1064	alcohol dehydrogenase
HUT12_15230	COG2133	pyrroloquinoline quinone binding
HUT12_15240	COG0583	DNA-binding transcription factor activity
HUT12_15285	COG2022	thiamine diphosphate biosynthetic process
HUT12_15285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_15295	COG3938	Belongs to the proline racemase family
HUT12_15300	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_15305	COG1802	Transcriptional regulator
HUT12_15310	COG1132	(ABC) transporter
HUT12_15315	COG1132	(ABC) transporter
HUT12_15325	COG0165	Argininosuccinate lyase
HUT12_15345	COG3842	ATPase activity
HUT12_15350	COG1840	ABC-type Fe3 transport system, periplasmic component
HUT12_15355	COG1940	carbohydrate kinase activity
HUT12_15360	COG0583	DNA-binding transcription factor activity
HUT12_15365	COG0667	Aldo Keto reductase
HUT12_15395	COG0601	transmembrane transport
HUT12_15405	COG0444	Belongs to the ABC transporter superfamily
HUT12_15410	COG4608	Belongs to the ABC transporter superfamily
HUT12_15415	COG1959	2 iron, 2 sulfur cluster binding
HUT12_15430	COG4208	sulfate ABC transporter
HUT12_15435	COG3842	ATPase activity
HUT12_15445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_15455	COG1116	anion transmembrane transporter activity
HUT12_15485	COG1609	Transcriptional regulator
HUT12_15495	COG1175	transmembrane transport
HUT12_15500	COG0395	ABC-type sugar transport system, permease component
HUT12_15530	COG4214	carbohydrate transport
HUT12_15540	COG3345	alpha-galactosidase
HUT12_15555	COG1879	ABC-type sugar transport system periplasmic component
HUT12_15565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_15570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_15575	COG2160	L-arabinose isomerase activity
HUT12_15580	COG2267	carboxylic ester hydrolase activity
HUT12_15590	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_15605	COG3509	depolymerase
HUT12_15615	COG1129	ABC transporter
HUT12_15620	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_15625	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_15640	COG1063	alcohol dehydrogenase
HUT12_15645	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_15710	COG3021	interspecies interaction between organisms
HUT12_15725	COG1131	(ABC) transporter
HUT12_15735	COG1309	transcriptional regulator
HUT12_15760	COG4221	oxidoreductase activity
HUT12_15840	COG3655	Transcriptional regulator
HUT12_15850	COG1609	Transcriptional regulator
HUT12_15855	COG1609	Transcriptional regulator
HUT12_15865	COG1175	transmembrane transport
HUT12_15870	COG0395	ABC-type sugar transport system, permease component
HUT12_15900	COG3509	depolymerase
HUT12_15925	COG2205	protein histidine kinase activity
HUT12_15930	COG0745	RESPONSE REGULATOR receiver
HUT12_15935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_15940	COG2304	oxidoreductase activity
HUT12_15950	COG0714	Associated with various cellular activities
HUT12_15965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUT12_15970	COG4326	sporulation control protein
HUT12_16035	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_16060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_16065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_16095	COG2197	response regulator
HUT12_16100	COG4585	Histidine kinase
HUT12_16135	COG0640	Transcriptional regulator
HUT12_16155	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_16170	COG0604	alcohol dehydrogenase
HUT12_16200	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_16220	COG1414	Transcriptional regulator
HUT12_16225	COG0800	Aldolase
HUT12_16230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_16235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT12_16275	COG5398	heme oxygenase
HUT12_16285	COG1120	ATPase activity
HUT12_16290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_16295	COG4558	Periplasmic binding protein
HUT12_16375	COG2814	Major facilitator Superfamily
HUT12_16420	COG0395	ABC-type sugar transport system, permease component
HUT12_16425	COG1063	alcohol dehydrogenase
HUT12_16435	COG4260	virion core protein, lumpy skin disease virus
HUT12_16460	COG0604	alcohol dehydrogenase
HUT12_16485	COG3608	succinylglutamate desuccinylase aspartoacylase
HUT12_16485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUT12_16515	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_16530	COG2207	Transcriptional regulator
HUT12_16545	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT12_16570	COG0439	Biotin carboxylase
HUT12_16585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT12_16605	COG2197	response regulator
HUT12_16640	COG1104	cysteine desulfurase activity
HUT12_16645	COG4106	trans-aconitate 2-methyltransferase activity
HUT12_16650	COG2353	YceI-like domain
HUT12_16735	COG5002	protein histidine kinase activity
HUT12_16735	COG5001	Diguanylate cyclase
HUT12_16735	COG3447	MASE1 domain protein
HUT12_16750	COG5006	permease, DMT superfamily
HUT12_16755	COG0531	amino acid
HUT12_16760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT12_16785	COG0018	arginyl-trna synthetase
HUT12_16800	COG0475	glutathione-regulated potassium exporter activity
HUT12_16825	COG0488	(ABC) transporter
HUT12_16835	COG0697	spore germination
HUT12_16840	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUT12_16850	COG3903	Transcriptional regulator
HUT12_16850	COG3629	intracellular signal transduction
HUT12_16900	COG2318	DinB family
HUT12_16910	COG2197	response regulator
HUT12_16915	COG4585	Histidine kinase
HUT12_16925	COG0387	Pfam Sodium calcium exchanger
HUT12_16935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_16940	COG0577	efflux transmembrane transporter activity
HUT12_16940	COG1136	(ABC) transporter
HUT12_16945	COG1136	(ABC) transporter
HUT12_16945	COG0577	efflux transmembrane transporter activity
HUT12_16950	COG2197	response regulator
HUT12_16955	COG4585	Histidine kinase
HUT12_16965	COG0517	IMP dehydrogenase activity
HUT12_16965	COG1994	Peptidase M50
HUT12_16985	COG1222	aaa ATPase
HUT12_16995	COG4122	O-methyltransferase activity
HUT12_17010	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT12_17015	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT12_17060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT12_17080	COG2378	regulation of single-species biofilm formation
HUT12_17090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT12_17110	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_17115	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_17135	COG1960	acyl-CoA dehydrogenase activity
HUT12_17195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_17265	COG2186	Transcriptional regulator
HUT12_17290	COG1960	acyl-CoA dehydrogenase activity
HUT12_17315	COG2378	regulation of single-species biofilm formation
HUT12_17320	COG0596	Alpha beta hydrolase
HUT12_17330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUT12_17335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUT12_17340	COG3485	protocatechuate 3,4-dioxygenase
HUT12_17345	COG3485	protocatechuate 3,4-dioxygenase
HUT12_17355	COG0596	Alpha beta hydrolase
HUT12_17360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT12_17365	COG1414	Transcriptional regulator
HUT12_17430	COG0573	inorganic phosphate transmembrane transporter activity
HUT12_17435	COG0581	inorganic phosphate transmembrane transporter activity
HUT12_17440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT12_17445	COG0745	RESPONSE REGULATOR receiver
HUT12_17470	COG2199	diguanylate cyclase activity
HUT12_17485	COG1609	Transcriptional regulator
HUT12_17495	COG0515	serine threonine protein kinase
HUT12_17495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT12_17515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT12_17535	COG1686	Belongs to the peptidase S11 family
HUT12_17540	COG1686	Belongs to the peptidase S11 family
HUT12_17545	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUT12_17565	COG2111	Na H antiporter
HUT12_17565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_17585	COG2212	antiporter activity
HUT12_17595	COG1690	Belongs to the RtcB family
HUT12_17615	COG3629	intracellular signal transduction
HUT12_17615	COG3903	Transcriptional regulator
HUT12_17625	COG1216	Glycosyl transferase, family 2
HUT12_17630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_17635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_17640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUT12_17645	COG1215	transferase activity, transferring glycosyl groups
HUT12_17650	COG1216	Glycosyl transferase, family 2
HUT12_17680	COG1131	(ABC) transporter
HUT12_17685	COG4585	Histidine kinase
HUT12_17690	COG2197	response regulator
HUT12_17725	COG0438	transferase activity, transferring glycosyl groups
HUT12_17740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT12_17745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT12_17770	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT12_17805	COG1609	Transcriptional regulator
HUT12_17810	COG0673	inositol 2-dehydrogenase activity
HUT12_17830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT12_17840	COG1960	acyl-CoA dehydrogenase activity
HUT12_17850	COG0406	alpha-ribazole phosphatase activity
HUT12_17855	COG0488	(ABC) transporter
HUT12_17865	COG1509	lysine 2,3-aminomutase activity
HUT12_17870	COG0604	alcohol dehydrogenase
HUT12_17875	COG1228	amidohydrolase
HUT12_17880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUT12_17885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_17890	COG1607	acyl-coa hydrolase
HUT12_17915	COG1216	Glycosyl transferase, family 2
HUT12_17940	COG1609	Transcriptional regulator
HUT12_17945	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_17950	COG1940	carbohydrate kinase activity
HUT12_17960	COG4209	transmembrane transport
HUT12_17965	COG0395	ABC-type sugar transport system, permease component
HUT12_17970	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT12_17980	COG0477	Major facilitator Superfamily
HUT12_17985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT12_17995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_18010	COG0071	Belongs to the small heat shock protein (HSP20) family
HUT12_18015	COG4974	Belongs to the 'phage' integrase family
HUT12_18025	COG1136	(ABC) transporter
HUT12_18025	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUT12_18030	COG1136	(ABC) transporter
HUT12_18030	COG0577	efflux transmembrane transporter activity
HUT12_18045	COG1435	thymidine kinase activity
HUT12_18050	COG2270	Major facilitator Superfamily
HUT12_18075	COG0204	Acyl-transferase
HUT12_18080	COG1271	oxidase subunit
HUT12_18085	COG1294	oxidase, subunit
HUT12_18105	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_18115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_18125	COG1335	isochorismatase
HUT12_18135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_18150	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_18160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_18175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT12_18210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT12_18235	COG0242	peptide deformylase activity
HUT12_18250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT12_18250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT12_18255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT12_18265	COG1017	nitric oxide dioxygenase activity
HUT12_18265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT12_18385	COG0437	4 iron, 4 sulfur cluster binding
HUT12_18410	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_18415	COG0644	oxidoreductase
HUT12_18445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT12_18485	COG1653	transport
HUT12_18490	COG1175	transmembrane transport
HUT12_18515	COG1357	PFAM Pentapeptide repeats (8 copies)
HUT12_18520	COG0328	RNA-DNA hybrid ribonuclease activity
HUT12_18560	COG3012	SEC-C Motif Domain Protein
HUT12_18590	COG0069	glutamate synthase activity
HUT12_18615	COG2197	response regulator
HUT12_18635	COG3265	gluconokinase activity
HUT12_18640	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_18650	COG0800	Aldolase
HUT12_18655	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_18660	COG0395	ABC-type sugar transport system, permease component
HUT12_18665	COG1175	transmembrane transport
HUT12_18695	COG1595	DNA-templated transcription, initiation
HUT12_18700	COG1090	epimerase
HUT12_18745	COG2197	response regulator
HUT12_18795	COG0697	spore germination
HUT12_18800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_18805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT12_18850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_18855	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HUT12_18860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT12_18905	COG2226	methyltransferase
HUT12_18920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HUT12_18955	COG1803	Methylglyoxal synthase
HUT12_18955	COG1597	lipid kinase activity
HUT12_18960	COG0789	Transcriptional regulator
HUT12_18965	COG0326	Molecular chaperone. Has ATPase activity
HUT12_18980	COG2205	protein histidine kinase activity
HUT12_18985	COG0745	RESPONSE REGULATOR receiver
HUT12_19000	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_19045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_19060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_19065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUT12_19080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_19085	COG0183	Belongs to the thiolase family
HUT12_19095	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT12_19100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_19110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_19130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_19145	COG1960	acyl-CoA dehydrogenase activity
HUT12_19150	COG1960	acyl-CoA dehydrogenase activity
HUT12_19180	COG2226	methyltransferase
HUT12_19180	COG3433	isochorismatase activity
HUT12_19180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_19185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_19185	COG3433	isochorismatase activity
HUT12_19185	COG2226	methyltransferase
HUT12_19190	COG2091	lysine biosynthetic process via aminoadipic acid
HUT12_19195	COG0477	Major facilitator Superfamily
HUT12_19210	COG2124	cytochrome p450
HUT12_19225	COG2124	cytochrome p450
HUT12_19245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_19280	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_19310	COG1116	anion transmembrane transporter activity
HUT12_19335	COG0683	leucine binding
HUT12_19350	COG0829	nickel cation binding
HUT12_19355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUT12_19370	COG0832	Belongs to the urease beta subunit family
HUT12_19380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_19385	COG0765	amino acid transport
HUT12_19390	COG1126	abc transporter atp-binding protein
HUT12_19425	COG3559	Exporter of polyketide antibiotics
HUT12_19430	COG1131	(ABC) transporter
HUT12_19435	COG1309	transcriptional regulator
HUT12_19445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT12_19450	COG0300	oxidoreductase activity
HUT12_19455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_19455	COG0596	Alpha beta hydrolase
HUT12_19490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_19495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUT12_19500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_19505	COG1116	anion transmembrane transporter activity
HUT12_19510	COG2855	membrane
HUT12_19525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT12_19550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_19565	COG3458	cephalosporin-C deacetylase activity
HUT12_19575	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_19580	COG4209	transmembrane transport
HUT12_19585	COG0395	ABC-type sugar transport system, permease component
HUT12_19590	COG1653	transport
HUT12_19615	COG1122	ATPase activity
HUT12_19625	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HUT12_19630	COG0310	cobalt ion transport
HUT12_19690	COG0076	glutamate decarboxylase activity
HUT12_19705	COG4221	oxidoreductase activity
HUT12_19710	COG2723	6-phospho-beta-galactosidase activity
HUT12_19715	COG0395	ABC-type sugar transport system, permease component
HUT12_19720	COG1175	transmembrane transport
HUT12_19740	COG0583	DNA-binding transcription factor activity
HUT12_19745	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_19750	COG1309	transcriptional regulator
HUT12_19760	COG0646	methionine synthase
HUT12_19760	COG1410	methionine synthase
HUT12_19775	COG0215	cysteine-tRNA ligase activity
HUT12_19805	COG1968	undecaprenyl-diphosphatase activity
HUT12_19810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_19815	COG0667	Aldo Keto reductase
HUT12_19830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_19860	COG0542	response to heat
HUT12_19880	COG1674	ftsk spoiiie
HUT12_19900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT12_19910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUT12_19920	COG0745	RESPONSE REGULATOR receiver
HUT12_19925	COG0745	RESPONSE REGULATOR receiver
HUT12_19960	COG0653	protein targeting
HUT12_19965	COG0463	Glycosyl transferase, family 2
HUT12_19975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT12_19980	COG1191	sigma factor activity
HUT12_20005	COG2409	Drug exporters of the RND superfamily
HUT12_20030	COG0137	argininosuccinate synthase activity
HUT12_20035	COG0583	DNA-binding transcription factor activity
HUT12_20050	COG3293	Transposase
HUT12_20055	COG3293	Transposase
HUT12_20125	COG2205	protein histidine kinase activity
HUT12_20130	COG0745	RESPONSE REGULATOR receiver
HUT12_20140	COG0515	serine threonine protein kinase
HUT12_20140	COG2815	serine threonine protein kinase
HUT12_20155	COG0784	Response regulator, receiver
HUT12_20160	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_20175	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_20195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_20205	COG0633	Ferredoxin
HUT12_20205	COG0543	2 iron, 2 sulfur cluster binding
HUT12_20210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT12_20225	COG2239	Acts as a magnesium transporter
HUT12_20235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_20265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT12_20275	COG0789	Transcriptional regulator
HUT12_20310	COG0489	protein tyrosine kinase activity
HUT12_20325	COG2119	membrane
HUT12_20330	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUT12_20335	COG0121	glutamine amidotransferase
HUT12_20340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT12_20360	COG0515	serine threonine protein kinase
HUT12_20380	COG2197	response regulator
HUT12_20410	COG0367	asparagine synthase
HUT12_20435	COG2197	response regulator
HUT12_20440	COG4585	Histidine kinase
HUT12_20455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT12_20475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT12_20495	COG1376	ErfK ybiS ycfS ynhG family protein
HUT12_20525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT12_20575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUT12_20590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_20595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_20610	COG0439	Biotin carboxylase
HUT12_20615	COG0511	ligase activity, forming carbon-carbon bonds
HUT12_20620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUT12_20620	COG0825	malonyl-CoA metabolic process
HUT12_20630	COG3629	intracellular signal transduction
HUT12_20630	COG3903	Transcriptional regulator
HUT12_20640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_20675	COG2197	response regulator
HUT12_20695	COG2226	methyltransferase
HUT12_20705	COG0738	Major facilitator superfamily
HUT12_20800	COG0706	membrane insertase activity
HUT12_20805	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_20810	COG0395	ABC-type sugar transport system, permease component
HUT12_20815	COG1175	transmembrane transport
HUT12_20825	COG1609	Transcriptional regulator
HUT12_20865	COG0395	ABC-type sugar transport system, permease component
HUT12_20870	COG1175	transmembrane transport
HUT12_20885	COG0673	inositol 2-dehydrogenase activity
HUT12_20890	COG1904	glucuronate isomerase
HUT12_20895	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_20900	COG0246	Mannitol dehydrogenase
HUT12_20905	COG0673	inositol 2-dehydrogenase activity
HUT12_20910	COG3866	Pectate lyase
HUT12_20930	COG2200	EAL domain
HUT12_20955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT12_20960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUT12_20975	COG2132	Multicopper oxidase
HUT12_21010	COG0667	Aldo Keto reductase
HUT12_21035	COG4585	Histidine kinase
HUT12_21090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT12_21115	COG1704	LemA family
HUT12_21140	COG0477	Major facilitator Superfamily
HUT12_21150	COG1136	(ABC) transporter
HUT12_21170	COG0009	L-threonylcarbamoyladenylate synthase
HUT12_21200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT12_21205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_21215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT12_21220	COG2226	methyltransferase
HUT12_21225	COG1609	Transcriptional regulator
HUT12_21240	COG1175	transmembrane transport
HUT12_21245	COG0395	ABC-type sugar transport system, permease component
HUT12_21255	COG1316	TRANSCRIPTIONal
HUT12_21270	COG0438	transferase activity, transferring glycosyl groups
HUT12_21335	COG0714	Associated with various cellular activities
HUT12_21350	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_21390	COG4733	cellulase activity
HUT12_21390	COG5297	Belongs to the glycosyl hydrolase family 6
HUT12_21395	COG2723	6-phospho-beta-galactosidase activity
HUT12_21405	COG2018	Roadblock/LC7 domain
HUT12_21425	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT12_21440	COG4585	Histidine kinase
HUT12_21450	COG0456	acetyltransferase
HUT12_21455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_21475	COG0662	Cupin 2, conserved barrel domain protein
HUT12_21485	COG0640	Transcriptional regulator
HUT12_21495	COG1595	DNA-templated transcription, initiation
HUT12_21500	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT12_21530	COG0300	oxidoreductase activity
HUT12_21560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT12_21600	COG0745	RESPONSE REGULATOR receiver
HUT12_21625	COG1695	Transcriptional regulator
HUT12_21635	COG2318	DinB family
HUT12_21640	COG2197	response regulator
HUT12_21650	COG3629	intracellular signal transduction
HUT12_21650	COG3903	Transcriptional regulator
HUT12_21725	COG3848	Pyruvate phosphate dikinase
HUT12_21725	COG0574	Belongs to the PEP-utilizing enzyme family
HUT12_21730	COG0789	Transcriptional regulator
HUT12_21735	COG1309	transcriptional regulator
HUT12_21755	COG2813	Specifically methylates the guanine in position
HUT12_21760	COG2318	DinB family
HUT12_21840	COG1131	(ABC) transporter
HUT12_21850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_21855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_21860	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_21860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_21860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_21860	COG3321	synthase
HUT12_21860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_21865	COG0300	oxidoreductase activity
HUT12_21865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_21865	COG4221	oxidoreductase activity
HUT12_21865	COG3321	synthase
HUT12_21880	COG1960	acyl-CoA dehydrogenase activity
HUT12_21895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_21900	COG2264	protein methyltransferase activity
HUT12_21960	COG0515	serine threonine protein kinase
HUT12_21960	COG2815	serine threonine protein kinase
HUT12_21975	COG1988	membrane-bound metal-dependent
HUT12_21990	COG1175	transmembrane transport
HUT12_21995	COG0395	ABC-type sugar transport system, permease component
HUT12_22000	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT12_22025	COG2080	2 iron, 2 sulfur cluster binding
HUT12_22030	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT12_22035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_22040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_22055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT12_22055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT12_22060	COG0346	lactoylglutathione lyase activity
HUT12_22065	COG0395	ABC-type sugar transport system, permease component
HUT12_22070	COG1175	transmembrane transport
HUT12_22080	COG4821	SIS domain
HUT12_22085	COG1737	Transcriptional regulator
HUT12_22095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUT12_22110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_22125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT12_22130	COG1365	unkown
HUT12_22150	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUT12_22155	COG0583	DNA-binding transcription factor activity
HUT12_22180	COG3214	Protein conserved in bacteria
HUT12_22190	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_22195	COG4608	Belongs to the ABC transporter superfamily
HUT12_22200	COG0444	Belongs to the ABC transporter superfamily
HUT12_22205	COG0747	negative chemotaxis
HUT12_22220	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_22225	COG0673	inositol 2-dehydrogenase activity
HUT12_22230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT12_22250	COG1414	Transcriptional regulator
HUT12_22255	COG0028	Belongs to the TPP enzyme family
HUT12_22305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUT12_22330	COG0714	Associated with various cellular activities
HUT12_22365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_22380	COG0006	proline dipeptidase activity
HUT12_22440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUT12_22455	COG2018	Roadblock/LC7 domain
HUT12_22495	COG1309	transcriptional regulator
HUT12_22505	COG3220	belongs to the UPF0276 family
HUT12_22515	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_22525	COG1132	(ABC) transporter
HUT12_22530	COG1024	Enoyl-CoA hydratase
HUT12_22545	COG0488	(ABC) transporter
HUT12_22550	COG2321	neutral zinc metallopeptidase
HUT12_22560	COG1072	(Pantothenic acid kinase))
HUT12_22575	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_22590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUT12_22600	COG0246	Mannitol dehydrogenase
HUT12_22605	COG2897	thiosulfate sulfurtransferase activity
HUT12_22630	COG0822	iron-sulfur transferase activity
HUT12_22635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT12_22640	COG0396	ATPase activity
HUT12_22645	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_22680	COG0109	protoheme IX farnesyltransferase activity
HUT12_22690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT12_22695	COG0166	Belongs to the GPI family
HUT12_22710	COG0363	glucosamine-6-phosphate deaminase activity
HUT12_22720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT12_22725	COG0149	triose-phosphate isomerase activity
HUT12_22730	COG0126	phosphoglycerate kinase activity
HUT12_22735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT12_22740	COG1481	regulation of sporulation
HUT12_22750	COG1660	Displays ATPase and GTPase activities
HUT12_22765	COG0322	excinuclease ABC activity
HUT12_22785	COG1162	GTPase activity
HUT12_22795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT12_22825	COG0270	DNA (cytosine-5-)-methyltransferase activity
HUT12_22895	COG5377	YqaJ viral recombinase family
HUT12_22980	COG0592	DNA-directed DNA polymerase activity
HUT12_23025	COG0305	Participates in initiation and elongation during chromosome replication
HUT12_23125	COG1783	phage Terminase large subunit
HUT12_23310	COG0494	nUDIX hydrolase
HUT12_23565	COG3293	Transposase
HUT12_23570	COG3293	Transposase
HUT12_23745	COG1278	Cold shock
HUT12_23760	COG1846	Transcriptional regulator
HUT12_23765	COG2409	Drug exporters of the RND superfamily
HUT12_23790	COG2365	Tyrosine phosphatase family
HUT12_23805	COG2329	Antibiotic biosynthesis monooxygenase
HUT12_23825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUT12_23825	COG0237	dephospho-CoA kinase activity
HUT12_23830	COG0539	negative regulation of cytoplasmic translation
HUT12_23835	COG2226	methyltransferase
HUT12_23850	COG0789	Transcriptional regulator
HUT12_23905	COG0626	cystathionine gamma-synthase activity
HUT12_23915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_23920	COG3401	FG-GAP repeat protein
HUT12_23930	COG0730	response to heat
HUT12_23940	COG1946	Acyl-CoA thioesterase
HUT12_23955	COG0667	Aldo Keto reductase
HUT12_23965	COG1253	flavin adenine dinucleotide binding
HUT12_24000	COG3293	Transposase
HUT12_24005	COG3293	Transposase
HUT12_24030	COG0070	glutamate synthase
HUT12_24030	COG0067	glutamate synthase
HUT12_24030	COG0069	glutamate synthase activity
HUT12_24045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUT12_24050	COG0159	tryptophan synthase activity
HUT12_24055	COG0133	tryptophan synthase activity
HUT12_24060	COG0134	indole-3-glycerol-phosphate synthase activity
HUT12_24080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT12_24105	COG1132	(ABC) transporter
HUT12_24110	COG1132	(ABC) transporter
HUT12_24120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_24125	COG1022	Amp-dependent synthetase and ligase
HUT12_24135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_24150	COG0107	imidazoleglycerol-phosphate synthase activity
HUT12_24155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUT12_24165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUT12_24175	COG0131	Imidazoleglycerol-phosphate dehydratase
HUT12_24180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT12_24185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUT12_24190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT12_24215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUT12_24245	COG1799	cell septum assembly
HUT12_24255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUT12_24265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUT12_24270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUT12_24280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT12_24290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT12_24295	COG0768	penicillin binding
HUT12_24305	COG0275	rRNA processing
HUT12_24310	COG2001	Belongs to the MraZ family
HUT12_24320	COG3442	glutamine amidotransferase
HUT12_24330	COG0495	leucyl-tRNA aminoacylation
HUT12_24355	COG1006	Multisubunit Na H antiporter MnhC subunit
HUT12_24360	COG2111	Na H antiporter
HUT12_24360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_24365	COG0714	Associated with various cellular activities
HUT12_24385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT12_24400	COG0587	DNA-directed DNA polymerase activity
HUT12_24470	COG2815	serine threonine protein kinase
HUT12_24470	COG0515	serine threonine protein kinase
HUT12_24475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT12_24485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT12_24510	COG4175	Glycine betaine
HUT12_24510	COG0517	IMP dehydrogenase activity
HUT12_24515	COG4176	ABC-type proline glycine betaine transport system permease component
HUT12_24520	COG2113	Glycine betaine
HUT12_24525	COG0386	Belongs to the glutathione peroxidase family
HUT12_24555	COG0205	6-phosphofructokinase activity
HUT12_24595	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT12_24605	COG2072	flavoprotein involved in K transport
HUT12_24615	COG1940	carbohydrate kinase activity
HUT12_24640	COG2197	response regulator
HUT12_24655	COG0438	transferase activity, transferring glycosyl groups
HUT12_24660	COG0501	Belongs to the peptidase M48B family
HUT12_24675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT12_24685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT12_24700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT12_24710	COG2010	Cytochrome c
HUT12_24730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT12_24745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUT12_24775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_24790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUT12_24795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT12_24810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HUT12_24815	COG1396	sequence-specific DNA binding
HUT12_24825	COG0667	Aldo Keto reductase
HUT12_24830	COG1994	Peptidase M50
HUT12_24845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT12_24850	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUT12_24860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT12_24865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT12_24875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT12_24880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_24920	COG0321	lipoyl(octanoyl) transferase activity
HUT12_24940	COG0017	Asparaginyl-tRNA synthetase
HUT12_24945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUT12_24985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT12_25015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUT12_25025	COG0174	glutamine synthetase
HUT12_25045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUT12_25050	COG0519	Catalyzes the synthesis of GMP from XMP
HUT12_25050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT12_25055	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT12_25065	COG3766	membrane
HUT12_25070	COG0174	glutamine synthetase
HUT12_25075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT12_25075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUT12_25080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT12_25095	COG0557	exoribonuclease II activity
HUT12_25125	COG2207	Transcriptional regulator
HUT12_25125	COG3708	Transcriptional regulator
HUT12_25140	COG2188	Transcriptional regulator
HUT12_25215	COG2188	Transcriptional regulator
HUT12_25235	COG1192	Involved in chromosome partitioning
HUT12_25250	COG2318	DinB family
HUT12_25265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUT12_25295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT12_25315	COG4279	zinc finger
HUT12_25320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT12_25330	COG2318	DinB family
HUT12_25350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUT12_25355	COG2267	carboxylic ester hydrolase activity
HUT12_25375	COG0022	dehydrogenase e1 component
HUT12_25380	COG1846	Transcriptional regulator
HUT12_25385	COG0432	Pfam Uncharacterised protein family UPF0047
HUT12_25390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT12_25415	COG2814	Major facilitator Superfamily
HUT12_25420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUT12_25445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT12_25450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_25475	COG0288	reversible hydration of carbon dioxide
HUT12_25485	COG3973	AAA domain
HUT12_25495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT12_25495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT12_25525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT12_25525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT12_25545	COG3268	Saccharopine dehydrogenase
HUT12_25550	COG0789	Transcriptional regulator
HUT12_25555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT12_25600	COG0277	FAD linked oxidase domain protein
HUT12_25635	COG1131	(ABC) transporter
HUT12_25670	COG4941	Belongs to the sigma-70 factor family
HUT12_25735	COG1940	carbohydrate kinase activity
HUT12_25785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUT12_25810	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_25815	COG1129	ABC transporter
HUT12_25845	COG2018	Roadblock/LC7 domain
HUT12_25850	COG2358	TRAP transporter, solute receptor (TAXI family
HUT12_25880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT12_25890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT12_25905	COG0574	Belongs to the PEP-utilizing enzyme family
HUT12_25905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT12_25930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT12_25935	COG0740	serine-type endopeptidase activity
HUT12_25940	COG0740	serine-type endopeptidase activity
HUT12_25945	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUT12_25970	COG2746	aminoglycoside 3-N-acetyltransferase activity
HUT12_25990	COG4552	Acetyltransferase involved in intracellular survival and related
HUT12_26000	COG0698	ribose 5-phosphate isomerase
HUT12_26010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT12_26020	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HUT12_26030	COG0154	amidase activity
HUT12_26040	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
HUT12_26055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_26060	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HUT12_26075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_26080	COG3844	kynureninase activity
HUT12_26085	COG3483	tryptophan 2,3-dioxygenase activity
HUT12_26090	COG1522	sequence-specific DNA binding
HUT12_26110	COG0668	transmembrane transport
HUT12_26120	COG2346	COG2346, Truncated hemoglobins
HUT12_26145	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT12_26150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_26150	COG0561	phosphatase activity
HUT12_26160	COG1648	precorrin-2 dehydrogenase activity
HUT12_26160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT12_26165	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT12_26180	COG1797	cobyrinic acid a,c-diamide synthase activity
HUT12_26190	COG1793	dna ligase
HUT12_26200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_26215	COG1492	cobalamin metabolic process
HUT12_26220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUT12_26225	COG0629	single-stranded DNA binding
HUT12_26280	COG2197	response regulator
HUT12_26335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUT12_26365	COG1566	PFAM secretion protein HlyD family protein
HUT12_26390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUT12_26395	COG1737	Transcriptional regulator
HUT12_26400	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_26405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT12_26430	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HUT12_26435	COG1653	transport
HUT12_26440	COG1175	transmembrane transport
HUT12_26445	COG0395	ABC-type sugar transport system, permease component
HUT12_26450	COG1609	Transcriptional regulator
HUT12_26455	COG0366	Alpha amylase catalytic
HUT12_26460	COG2814	Major facilitator Superfamily
HUT12_26465	COG1070	Carbohydrate kinase
HUT12_26470	COG2115	Belongs to the xylose isomerase family
HUT12_26545	COG5297	Belongs to the glycosyl hydrolase family 6
HUT12_26560	COG2902	Dehydrogenase
HUT12_26580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_26580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_26595	COG0183	Belongs to the thiolase family
HUT12_26600	COG0346	lactoylglutathione lyase activity
HUT12_26645	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_26650	COG1716	ATPase activity
HUT12_26665	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUT12_26685	COG1131	(ABC) transporter
HUT12_26695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_26700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT12_26715	COG2755	lipolytic protein G-D-S-L family
HUT12_26725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUT12_26735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUT12_26740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUT12_26745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUT12_26750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT12_26755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUT12_26760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT12_26765	COG0356	it plays a direct role in the translocation of protons across the membrane
HUT12_26780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT12_26785	COG0702	epimerase
HUT12_26790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT12_26795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT12_26800	COG0009	L-threonylcarbamoyladenylate synthase
HUT12_26805	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT12_26810	COG3706	GGDEF domain
HUT12_26815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUT12_26820	COG0254	rRNA binding
HUT12_26830	COG0083	homoserine kinase activity
HUT12_26845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUT12_26850	COG1132	(ABC) transporter
HUT12_26855	COG1309	transcriptional regulator
HUT12_26865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT12_26870	COG0460	homoserine dehydrogenase
HUT12_26875	COG0019	diaminopimelate decarboxylase activity
HUT12_26880	COG0018	arginyl-trna synthetase
HUT12_26920	COG3285	dna ligase
HUT12_26920	COG1793	dna ligase
HUT12_26935	COG2409	Drug exporters of the RND superfamily
HUT12_26950	COG0673	inositol 2-dehydrogenase activity
HUT12_26970	COG0366	Alpha amylase catalytic
HUT12_26980	COG0586	Pfam SNARE associated Golgi protein
HUT12_26995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT12_27000	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT12_27055	COG1834	amidinotransferase
HUT12_27060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_27070	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT12_27095	COG0515	serine threonine protein kinase
HUT12_27110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_27115	COG2205	protein histidine kinase activity
HUT12_27120	COG0745	RESPONSE REGULATOR receiver
HUT12_27140	COG1131	(ABC) transporter
HUT12_27150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_27150	COG0567	Dehydrogenase, E1 component
HUT12_27175	COG0280	phosphate acetyltransferase
HUT12_27175	COG0857	belongs to the CobB CobQ family
HUT12_27180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUT12_27220	COG2172	sigma factor antagonist activity
HUT12_27230	COG1597	lipid kinase activity
HUT12_27245	COG0175	sulfate reduction
HUT12_27270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT12_27285	COG1309	transcriptional regulator
HUT12_27295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUT12_27300	COG5662	AntiSigma factor
HUT12_27305	COG1595	DNA-templated transcription, initiation
HUT12_27325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT12_27335	COG0483	inositol monophosphate 1-phosphatase activity
HUT12_27345	COG0438	transferase activity, transferring glycosyl groups
HUT12_27360	COG4585	Histidine kinase
HUT12_27370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUT12_27390	COG1615	UPF0182 protein
HUT12_27395	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT12_27425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT12_27495	COG1278	Cold shock
HUT12_27510	COG1611	Belongs to the LOG family
HUT12_27515	COG1611	Belongs to the LOG family
HUT12_27525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_27530	COG2171	N-acyltransferase activity
HUT12_27535	COG1404	Belongs to the peptidase S8 family
HUT12_27540	COG0110	maltose O-acetyltransferase activity
HUT12_27560	COG0287	Prephenate dehydrogenase
HUT12_27590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT12_27635	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT12_27645	COG2226	methyltransferase
HUT12_27650	COG2949	membrane
HUT12_27665	COG0012	GTP binding
HUT12_27680	COG2169	Transcriptional regulator
HUT12_27680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT12_27685	COG1132	(ABC) transporter
HUT12_27690	COG1132	(ABC) transporter
HUT12_27695	COG0525	valine-tRNA ligase activity
HUT12_27715	COG1131	(ABC) transporter
HUT12_27725	COG0529	Catalyzes the synthesis of activated sulfate
HUT12_27730	COG1349	DNA-binding transcription factor activity
HUT12_27760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT12_27765	COG0747	negative chemotaxis
HUT12_27770	COG0601	transmembrane transport
HUT12_27775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_27780	COG0444	Belongs to the ABC transporter superfamily
HUT12_27785	COG4608	Belongs to the ABC transporter superfamily
HUT12_27790	COG0138	bifunctional purine biosynthesis protein purh
HUT12_27825	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT12_27830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_27835	COG0739	heme binding
HUT12_27840	COG0741	lytic transglycosylase activity
HUT12_27840	COG1196	nuclear chromosome segregation
HUT12_27840	COG0739	heme binding
HUT12_27850	COG1605	Chorismate mutase
HUT12_27855	COG4608	Belongs to the ABC transporter superfamily
HUT12_27860	COG0444	Belongs to the ABC transporter superfamily
HUT12_27870	COG0601	transmembrane transport
HUT12_27880	COG2197	response regulator
HUT12_27885	COG4585	Histidine kinase
HUT12_27900	COG0688	phosphatidylethanolamine metabolic process
HUT12_27905	COG1183	phosphatidylcholine synthase activity
HUT12_27915	COG1051	belongs to the nudix hydrolase family
HUT12_27925	COG0519	Catalyzes the synthesis of GMP from XMP
HUT12_27925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT12_27935	COG1316	TRANSCRIPTIONal
HUT12_27945	COG0516	GMP reductase activity
HUT12_27960	COG2197	response regulator
HUT12_27975	COG0459	protein refolding
HUT12_27980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT12_28005	COG4213	ABC transporter substrate-binding protein
HUT12_28015	COG4214	carbohydrate transport
HUT12_28040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT12_28050	COG1214	PFAM Peptidase M22, glycoprotease
HUT12_28050	COG0456	acetyltransferase
HUT12_28055	COG1595	DNA-templated transcription, initiation
HUT12_28065	COG1404	Belongs to the peptidase S8 family
HUT12_28070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT12_28075	COG0802	atpase or kinase
HUT12_28085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT12_28105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT12_28115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT12_28120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUT12_28125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUT12_28130	COG2223	nitrite transmembrane transporter activity
HUT12_28145	COG2813	Specifically methylates the guanine in position
HUT12_28150	COG0243	molybdopterin cofactor binding
HUT12_28155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_28160	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_28160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_28165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_28165	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_28185	COG2018	Roadblock/LC7 domain
HUT12_28200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_28230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUT12_28235	COG0351	phosphomethylpyrimidine kinase
HUT12_28240	COG0352	thiamine-phosphate diphosphorylase activity
HUT12_28245	COG2022	thiamine diphosphate biosynthetic process
HUT12_28255	COG2022	thiamine diphosphate biosynthetic process
HUT12_28255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_28260	COG0352	thiamine-phosphate diphosphorylase activity
HUT12_28270	COG0667	Aldo Keto reductase
HUT12_28275	COG0488	(ABC) transporter
HUT12_28280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUT12_28290	COG0101	tRNA pseudouridine synthase activity
HUT12_28295	COG0203	ribosomal protein L17
HUT12_28300	COG0202	RNA polymerase activity
HUT12_28305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT12_28310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUT12_28315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUT12_28320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT12_28325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUT12_28340	COG0563	adenylate kinase activity
HUT12_28350	COG0200	Binds to the 23S rRNA
HUT12_28355	COG1841	ribosomal large subunit assembly
HUT12_28360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUT12_28365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUT12_28370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUT12_28375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUT12_28380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT12_28385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUT12_28390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUT12_28395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUT12_28400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUT12_28405	COG0255	Belongs to the universal ribosomal protein uL29 family
HUT12_28410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUT12_28415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUT12_28420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUT12_28425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUT12_28430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUT12_28440	COG0088	Forms part of the polypeptide exit tunnel
HUT12_28445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUT12_28450	COG0051	transcription antitermination factor activity, RNA binding
HUT12_28455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT12_28460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT12_28465	COG0049	tRNA binding
HUT12_28470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUT12_28485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUT12_28490	COG0085	RNA polymerase activity
HUT12_28495	COG0222	ribosome binding
HUT12_28510	COG1121	(ABC) transporter
HUT12_28515	COG0081	regulation of translation
HUT12_28520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUT12_28545	COG2030	dehydratase
HUT12_28550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT12_28580	COG1666	GTP binding
HUT12_28585	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_28590	COG1309	transcriptional regulator
HUT12_28600	COG0501	Belongs to the peptidase M48B family
HUT12_28605	COG1007	ATP synthesis coupled electron transport
HUT12_28610	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_28620	COG0713	ATP synthesis coupled electron transport
HUT12_28625	COG0839	Belongs to the complex I subunit 6 family
HUT12_28630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_28635	COG0435	Glutathione S-transferase
HUT12_28640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT12_28645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_28650	COG1063	alcohol dehydrogenase
HUT12_28660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_28670	COG2211	Major facilitator Superfamily
HUT12_28680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUT12_28685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT12_28735	COG0513	Belongs to the DEAD box helicase family
HUT12_28765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUT12_28770	COG0569	domain protein
HUT12_28775	COG0515	serine threonine protein kinase
HUT12_28790	COG0483	inositol monophosphate 1-phosphatase activity
HUT12_28795	COG0784	Response regulator, receiver
HUT12_28800	COG4251	negative regulation of phosphorylation
HUT12_28805	COG0745	RESPONSE REGULATOR receiver
HUT12_28810	COG2234	aminopeptidase activity
HUT12_28830	COG0488	(ABC) transporter
HUT12_28835	COG2226	methyltransferase
HUT12_28860	COG0456	acetyltransferase
HUT12_28870	COG0113	porphobilinogen synthase activity
HUT12_28875	COG1648	precorrin-2 dehydrogenase activity
HUT12_28875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT12_28880	COG0181	hydroxymethylbilane synthase activity
HUT12_28885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUT12_28890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUT12_28905	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_28910	COG1595	DNA-templated transcription, initiation
HUT12_28920	COG0560	Phosphoserine phosphatase
HUT12_28945	COG0577	efflux transmembrane transporter activity
HUT12_28945	COG1136	(ABC) transporter
HUT12_28950	COG0577	efflux transmembrane transporter activity
HUT12_28950	COG1136	(ABC) transporter
HUT12_28970	COG0596	Alpha beta hydrolase
HUT12_28975	COG0506	proline dehydrogenase activity
HUT12_29000	COG0423	glycine-tRNA ligase activity
HUT12_29020	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT12_29020	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUT12_29025	COG1121	(ABC) transporter
HUT12_29030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT12_29055	COG4821	SIS domain
HUT12_29060	COG0596	Alpha beta hydrolase
HUT12_29070	COG0701	Predicted permease
HUT12_29075	COG4721	ABC-type cobalt transport system, permease component
HUT12_29080	COG4172	Belongs to the ABC transporter superfamily
HUT12_29095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUT12_29105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT12_29110	COG1381	Involved in DNA repair and RecF pathway recombination
HUT12_29125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUT12_29140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT12_29155	COG0537	adenosine 5'-monophosphoramidase activity
HUT12_29160	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_29170	COG0484	heat shock protein binding
HUT12_29175	COG1420	regulation of RNA biosynthetic process
HUT12_29190	COG1024	Enoyl-CoA hydratase
HUT12_29210	COG0395	ABC-type sugar transport system, permease component
HUT12_29215	COG1175	transmembrane transport
HUT12_29235	COG0481	GTPase activity
HUT12_29250	COG0268	Binds directly to 16S ribosomal RNA
HUT12_29265	COG0658	competence protein
HUT12_29265	COG2333	competence protein COMEC
HUT12_29270	COG1596	polysaccharide export
HUT12_29270	COG1555	photosystem II stabilization
HUT12_29280	COG1307	EDD domain protein, DegV family
HUT12_29285	COG0406	alpha-ribazole phosphatase activity
HUT12_29290	COG0799	negative regulation of ribosome biogenesis
HUT12_29295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUT12_29315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT12_29320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUT12_29325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUT12_29330	COG1530	ribonuclease E activity
HUT12_29350	COG0204	Acyl-transferase
HUT12_29355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUT12_29360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT12_29365	COG1595	DNA-templated transcription, initiation
HUT12_29370	COG0105	UTP biosynthetic process
HUT12_29385	COG0285	dihydrofolate synthase activity
HUT12_29390	COG0525	valine-tRNA ligase activity
HUT12_29430	COG0754	glutathionylspermidine amidase activity
HUT12_29440	COG1082	Xylose isomerase domain protein TIM barrel
HUT12_29445	COG0248	Ppx GppA phosphatase
HUT12_29460	COG5002	protein histidine kinase activity
HUT12_29470	COG0588	phosphoglycerate mutase activity
HUT12_29495	COG0438	transferase activity, transferring glycosyl groups
HUT12_29505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUT12_29525	COG0395	ABC-type sugar transport system, permease component
HUT12_29540	COG0251	oxidation-reduction process
HUT12_29555	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HUT12_29570	COG1131	(ABC) transporter
HUT12_29580	COG4585	Histidine kinase
HUT12_29585	COG2197	response regulator
HUT12_29600	COG0513	Belongs to the DEAD box helicase family
HUT12_29645	COG3246	L-lysine catabolic process to acetate
HUT12_29650	COG0354	folic acid binding
HUT12_29655	COG0735	belongs to the Fur family
HUT12_29665	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HUT12_29695	COG4412	M6 family metalloprotease domain protein
HUT12_29695	COG1404	Belongs to the peptidase S8 family
HUT12_29715	COG2897	thiosulfate sulfurtransferase activity
HUT12_29730	COG0745	RESPONSE REGULATOR receiver
HUT12_29735	COG0726	polysaccharide deacetylase
HUT12_29740	COG0456	acetyltransferase
HUT12_29765	COG2326	polyphosphate kinase activity
HUT12_29795	COG2339	peptidase activity
HUT12_29800	COG4129	membrane
HUT12_29815	COG0277	FAD linked oxidase domain protein
HUT12_29845	COG0459	protein refolding
HUT12_29855	COG1278	Cold shock
HUT12_29865	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_29870	COG0456	acetyltransferase
HUT12_29875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT12_29895	COG1131	(ABC) transporter
HUT12_29910	COG2018	Roadblock/LC7 domain
HUT12_29930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT12_29935	COG1247	-acetyltransferase
HUT12_29955	COG1131	(ABC) transporter
HUT12_29960	COG1349	DNA-binding transcription factor activity
HUT12_29965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT12_29970	COG1940	carbohydrate kinase activity
HUT12_30015	COG1216	Glycosyl transferase, family 2
HUT12_30040	COG3842	ATPase activity
HUT12_30045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT12_30050	COG0215	cysteine-tRNA ligase activity
HUT12_30065	COG1404	Belongs to the peptidase S8 family
HUT12_30070	COG1011	Hydrolase
HUT12_30085	COG0114	fumarate hydratase activity
HUT12_30095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT12_30095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT12_30120	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT12_30135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT12_30170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUT12_30175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUT12_30210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT12_30225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUT12_30230	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUT12_30240	COG0242	peptide deformylase activity
HUT12_30245	COG3830	Belongs to the UPF0237 family
HUT12_30270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUT12_30280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT12_30290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT12_30300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT12_30305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT12_30320	COG0649	NAD binding
HUT12_30335	COG1174	glycine betaine transport
HUT12_30340	COG1174	glycine betaine transport
HUT12_30375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUT12_30410	COG0739	heme binding
HUT12_30410	COG1196	nuclear chromosome segregation
HUT12_30410	COG0741	lytic transglycosylase activity
HUT12_30435	COG0302	gtp cyclohydrolase
HUT12_30440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT12_30455	COG4977	sequence-specific DNA binding
HUT12_30460	COG0405	Gamma-glutamyltransferase
HUT12_30465	COG0037	tRNA processing
HUT12_30475	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT12_30480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT12_30490	COG1674	ftsk spoiiie
HUT12_30500	COG0671	phosphoesterase, PA-phosphatase related
HUT12_30515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT12_30520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUT12_30555	COG1960	acyl-CoA dehydrogenase activity
HUT12_30560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT12_30610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT12_30650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT12_30655	COG1610	YqeY-like protein
HUT12_30660	COG1408	metallophosphoesterase
HUT12_30680	COG2192	nodulation
HUT12_30690	COG1280	lysine exporter protein (LysE YggA)
HUT12_30720	COG0133	tryptophan synthase activity
HUT12_30725	COG0159	tryptophan synthase activity
HUT12_30730	COG2188	Transcriptional regulator
HUT12_30740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT12_30790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_30795	COG0477	Major facilitator Superfamily
HUT12_30810	COG4608	Belongs to the ABC transporter superfamily
HUT12_30830	COG0747	negative chemotaxis
HUT12_30835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUT12_30840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT12_30930	COG0813	purine-nucleoside phosphorylase activity
HUT12_30945	COG0590	tRNA wobble adenosine to inosine editing
HUT12_30975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT12_30975	COG1796	DNA polymerase
HUT12_30995	COG4981	capsule polysaccharide biosynthetic process
HUT12_31005	COG0438	transferase activity, transferring glycosyl groups
HUT12_31125	COG1674	ftsk spoiiie
HUT12_31140	COG1404	Belongs to the peptidase S8 family
HUT12_31165	COG0464	growth
HUT12_31180	COG0738	Major facilitator superfamily
HUT12_31215	COG0019	diaminopimelate decarboxylase activity
HUT12_31220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_31240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_31250	COG0483	inositol monophosphate 1-phosphatase activity
HUT12_31260	COG3903	Transcriptional regulator
HUT12_31260	COG3629	intracellular signal transduction
HUT12_31285	COG3852	Histidine kinase
HUT12_31315	COG1309	transcriptional regulator
HUT12_31400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT12_31400	COG2755	lipolytic protein G-D-S-L family
HUT12_31450	COG0242	peptide deformylase activity
HUT12_31470	COG1881	PFAM PEBP family protein
HUT12_31490	COG0789	Transcriptional regulator
HUT12_31495	COG3959	Transketolase, thiamine diphosphate binding domain
HUT12_31500	COG3958	Transketolase
HUT12_31505	COG0463	Glycosyl transferase, family 2
HUT12_31530	COG0183	Belongs to the thiolase family
HUT12_31540	COG0705	Rhomboid family
HUT12_31555	COG0598	Magnesium transport protein CorA
HUT12_31560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_31585	COG0371	Dehydrogenase
HUT12_31600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT12_31605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT12_31610	COG3275	phosphorelay sensor kinase activity
HUT12_31630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT12_31670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT12_31675	COG1088	dTDP-glucose 4,6-dehydratase activity
HUT12_31705	COG5002	protein histidine kinase activity
HUT12_31740	COG0077	Prephenate dehydratase
HUT12_31755	COG1764	response to oxidative stress
HUT12_31765	COG0561	phosphatase activity
HUT12_31770	COG0561	phosphatase activity
HUT12_31790	COG1834	amidinotransferase
HUT12_31795	COG1522	sequence-specific DNA binding
HUT12_31820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUT12_31850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT12_31860	COG1408	metallophosphoesterase
HUT12_31905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUT12_31910	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT12_31915	COG3903	Transcriptional regulator
HUT12_31915	COG3629	intracellular signal transduction
HUT12_31940	COG0305	Participates in initiation and elongation during chromosome replication
HUT12_31950	COG0359	binds to the 23S rRNA
HUT12_31955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT12_31965	COG0360	Binds together with S18 to 16S ribosomal RNA
HUT12_31970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT12_31985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT12_31995	COG1695	Transcriptional regulator
HUT12_32000	COG1260	myo-inositol-1-phosphate synthase
HUT12_32005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT12_32015	COG0617	tRNA 3'-terminal CCA addition
HUT12_32030	COG1595	DNA-templated transcription, initiation
HUT12_32045	COG3118	belongs to the thioredoxin family
HUT12_32050	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUT12_32050	COG3409	Peptidoglycan-binding domain 1 protein
HUT12_32060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_32065	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT12_32080	COG1192	Involved in chromosome partitioning
HUT12_32085	COG0357	Ribosomal RNA small subunit methyltransferase G
HUT12_32095	COG0706	membrane insertase activity
HUT12_32100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT12_32105	COG0594	ribonuclease P activity
HUT12_32110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUT12_32120	COG0592	DNA-directed DNA polymerase activity
HUT12_32125	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT12_32130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT12_32135	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUT12_32145	COG0187	DNA topoisomerase II activity
HUT12_32155	COG3293	Transposase
HUT12_32255	COG0739	heme binding
HUT12_32400	COG2188	Transcriptional regulator
HUT12_32445	COG1674	ftsk spoiiie