locus-tag	class	description
MM35RIKEN_00040	COG3620	sequence-specific DNA binding
MM35RIKEN_00050	COG1674	ftsk spoiiie
MM35RIKEN_00060	COG1674	ftsk spoiiie
MM35RIKEN_00070	COG2946	Replication initiation factor
MM35RIKEN_00220	COG0741	lytic transglycosylase activity
MM35RIKEN_00220	COG0791	NLP P60 protein
MM35RIKEN_00240	COG1917	Cupin 2, conserved barrel domain protein
MM35RIKEN_00240	COG1396	sequence-specific DNA binding
MM35RIKEN_00350	COG1959	2 iron, 2 sulfur cluster binding
MM35RIKEN_00390	COG0069	glutamate synthase activity
MM35RIKEN_00400	COG0067	glutamate synthase
MM35RIKEN_00420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MM35RIKEN_00440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MM35RIKEN_00460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MM35RIKEN_00490	COG2217	Heavy metal translocating P-type atpase
MM35RIKEN_00500	COG1196	nuclear chromosome segregation
MM35RIKEN_00510	COG0552	protein localization to endoplasmic reticulum
MM35RIKEN_00520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MM35RIKEN_00540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MM35RIKEN_00550	COG1534	Rna-binding protein
MM35RIKEN_00560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MM35RIKEN_00570	COG0799	negative regulation of ribosome biogenesis
MM35RIKEN_00660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MM35RIKEN_00660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MM35RIKEN_00670	COG2059	Chromate
MM35RIKEN_00700	COG4224	UPF0291 protein
MM35RIKEN_00710	COG2302	S4 RNA-binding domain
MM35RIKEN_00720	COG4932	domain protein
MM35RIKEN_00720	COG5492	domain, Protein
MM35RIKEN_00750	COG0572	uridine kinase
MM35RIKEN_00770	COG0544	peptidyl-prolyl cis-trans isomerase activity
MM35RIKEN_00790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MM35RIKEN_00810	COG0493	'glutamate synthase
MM35RIKEN_00810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM35RIKEN_00820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MM35RIKEN_00870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM35RIKEN_00880	COG0697	spore germination
MM35RIKEN_00920	COG0742	ribosomal rna small subunit methyltransferase
MM35RIKEN_00930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MM35RIKEN_00970	COG0275	rRNA processing
MM35RIKEN_01000	COG0768	penicillin binding
MM35RIKEN_01020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MM35RIKEN_01030	COG0772	Belongs to the SEDS family
MM35RIKEN_01040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MM35RIKEN_01050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MM35RIKEN_01060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MM35RIKEN_01070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MM35RIKEN_01100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MM35RIKEN_01110	COG0750	zinc metalloprotease
MM35RIKEN_01250	COG1393	Belongs to the ArsC family
MM35RIKEN_01320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MM35RIKEN_01340	COG2333	competence protein COMEC
MM35RIKEN_01340	COG0658	competence protein
MM35RIKEN_01360	COG1285	pathogenesis
MM35RIKEN_01370	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM35RIKEN_01420	COG0438	transferase activity, transferring glycosyl groups
MM35RIKEN_01430	COG3475	LICD family
MM35RIKEN_01460	COG1215	transferase activity, transferring glycosyl groups
MM35RIKEN_01480	COG0612	Peptidase, M16
MM35RIKEN_01490	COG0612	Peptidase, M16
MM35RIKEN_01510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MM35RIKEN_01520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MM35RIKEN_01530	COG1307	EDD domain protein, DegV family
MM35RIKEN_01580	COG0072	phenylalanine-tRNA ligase activity
MM35RIKEN_01580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MM35RIKEN_01600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MM35RIKEN_01600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MM35RIKEN_01620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MM35RIKEN_01630	COG2337	Toxic component of a toxin-antitoxin (TA) module
MM35RIKEN_01640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MM35RIKEN_01660	COG2323	membrane
MM35RIKEN_01670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MM35RIKEN_01690	COG2081	HI0933 family
MM35RIKEN_01700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MM35RIKEN_01710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MM35RIKEN_01730	COG0250	Participates in transcription elongation, termination and antitermination
MM35RIKEN_01740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MM35RIKEN_01750	COG0081	regulation of translation
MM35RIKEN_01760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MM35RIKEN_01800	COG0425	Belongs to the sulfur carrier protein TusA family
MM35RIKEN_01820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MM35RIKEN_01820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MM35RIKEN_01840	COG0590	tRNA wobble adenosine to inosine editing
MM35RIKEN_01860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MM35RIKEN_01870	COG1234	tRNA 3'-trailer cleavage
MM35RIKEN_01920	COG1827	regulation of RNA biosynthetic process
MM35RIKEN_01990	COG0156	8-amino-7-oxononanoate synthase activity
MM35RIKEN_02000	COG1028	Short-chain dehydrogenase reductase Sdr
MM35RIKEN_02010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM35RIKEN_02030	COG0233	cytoplasmic translational termination
MM35RIKEN_02040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MM35RIKEN_02050	COG4589	Belongs to the CDS family
MM35RIKEN_02060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MM35RIKEN_02070	COG0750	zinc metalloprotease
MM35RIKEN_02080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MM35RIKEN_02090	COG2176	DNA-directed DNA polymerase activity
MM35RIKEN_02110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MM35RIKEN_02120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MM35RIKEN_02140	COG0426	domain, Protein
MM35RIKEN_02140	COG1773	rubredoxin
MM35RIKEN_02150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MM35RIKEN_02170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MM35RIKEN_02180	COG1024	Enoyl-CoA hydratase
MM35RIKEN_02190	COG1250	3-hydroxyacyl-CoA dehydrogenase
MM35RIKEN_02200	COG1960	acyl-CoA dehydrogenase activity
MM35RIKEN_02260	COG4475	Protein of unknown function (DUF436)
MM35RIKEN_02280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM35RIKEN_02290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MM35RIKEN_02320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MM35RIKEN_02340	COG1937	Protein conserved in bacteria
MM35RIKEN_02350	COG2217	Heavy metal translocating P-type atpase
MM35RIKEN_02370	COG0582	viral genome integration into host DNA
MM35RIKEN_02400	COG1475	DNA binding
MM35RIKEN_02580	COG1484	DNA-dependent DNA replication
MM35RIKEN_02680	COG3620	sequence-specific DNA binding
MM35RIKEN_02780	COG0791	NLP P60 protein
MM35RIKEN_02780	COG0741	lytic transglycosylase activity
MM35RIKEN_02820	COG0551	DNA topoisomerase type I activity
MM35RIKEN_02820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM35RIKEN_02900	COG0358	DNA primase activity
MM35RIKEN_02930	COG0551	DNA topoisomerase type I activity
MM35RIKEN_02930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM35RIKEN_02980	COG3843	relaxase mobilization nuclease domain protein
MM35RIKEN_03000	COG2207	Transcriptional regulator
MM35RIKEN_03000	COG1609	Transcriptional regulator
MM35RIKEN_03030	COG1129	ABC transporter
MM35RIKEN_03040	COG2375	cellular response to nickel ion
MM35RIKEN_03040	COG1132	(ABC) transporter
MM35RIKEN_03050	COG1132	(ABC) transporter
MM35RIKEN_03120	COG1217	gtp-binding protein TYPA
MM35RIKEN_03130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MM35RIKEN_03140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MM35RIKEN_03150	COG1116	anion transmembrane transporter activity
MM35RIKEN_03160	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MM35RIKEN_03170	COG0352	thiamine-phosphate diphosphorylase activity
MM35RIKEN_03170	COG0351	phosphomethylpyrimidine kinase
MM35RIKEN_03180	COG0352	thiamine-phosphate diphosphorylase activity
MM35RIKEN_03250	COG0052	Belongs to the universal ribosomal protein uS2 family
MM35RIKEN_03260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MM35RIKEN_03320	COG2080	2 iron, 2 sulfur cluster binding
MM35RIKEN_03320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MM35RIKEN_03350	COG1309	transcriptional regulator
MM35RIKEN_03410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MM35RIKEN_03430	COG1028	Short-chain dehydrogenase reductase Sdr
MM35RIKEN_03440	COG0427	acetyl-CoA hydrolase
MM35RIKEN_03470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MM35RIKEN_03480	COG1454	alcohol dehydrogenase
MM35RIKEN_03490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MM35RIKEN_03510	COG1301	dicarboxylic acid transport
MM35RIKEN_03520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM35RIKEN_03570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MM35RIKEN_03880	COG0791	NLP P60 protein
MM35RIKEN_03880	COG0741	lytic transglycosylase activity
MM35RIKEN_04030	COG1028	Short-chain dehydrogenase reductase Sdr
MM35RIKEN_04040	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_04080	COG0116	Belongs to the methyltransferase superfamily
MM35RIKEN_04080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MM35RIKEN_04090	COG1122	ATPase activity
MM35RIKEN_04110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MM35RIKEN_04120	COG0101	tRNA pseudouridine synthase activity
MM35RIKEN_04150	COG0542	response to heat
MM35RIKEN_04220	COG1451	nucleotide metabolic process
MM35RIKEN_04240	COG1051	belongs to the nudix hydrolase family
MM35RIKEN_04250	COG1683	Conserved Protein
MM35RIKEN_04270	COG1122	ATPase activity
MM35RIKEN_04280	COG4120	Belongs to the binding-protein-dependent transport system permease family
MM35RIKEN_04310	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MM35RIKEN_04380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MM35RIKEN_04390	COG1739	Uncharacterized protein family UPF0029
MM35RIKEN_04410	COG2195	Cleaves the N-terminal amino acid of tripeptides
MM35RIKEN_04420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MM35RIKEN_04430	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MM35RIKEN_04440	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MM35RIKEN_04450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MM35RIKEN_04470	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MM35RIKEN_04480	COG1074	ATP-dependent DNA helicase activity
MM35RIKEN_04490	COG0254	rRNA binding
MM35RIKEN_04500	COG1191	sigma factor activity
MM35RIKEN_04510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MM35RIKEN_04560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MM35RIKEN_04570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MM35RIKEN_04580	COG4481	Protein conserved in bacteria
MM35RIKEN_04600	COG0813	purine-nucleoside phosphorylase activity
MM35RIKEN_04620	COG3845	ABC transporter
MM35RIKEN_04630	COG4603	Belongs to the binding-protein-dependent transport system permease family
MM35RIKEN_04640	COG1079	Belongs to the binding-protein-dependent transport system permease family
MM35RIKEN_04660	COG2186	Transcriptional regulator
MM35RIKEN_04670	COG0129	dihydroxy-acid dehydratase activity
MM35RIKEN_04770	COG1151	hydroxylamine reductase activity
MM35RIKEN_04820	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_04860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MM35RIKEN_04880	COG1773	rubredoxin
MM35RIKEN_04920	COG4716	Myosin-crossreactive antigen
MM35RIKEN_04990	COG5002	protein histidine kinase activity
MM35RIKEN_05050	COG0564	pseudouridine synthase activity
MM35RIKEN_05060	COG1686	Belongs to the peptidase S11 family
MM35RIKEN_05070	COG1555	photosystem II stabilization
MM35RIKEN_05070	COG1596	polysaccharide export
MM35RIKEN_05080	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_05090	COG5002	protein histidine kinase activity
MM35RIKEN_05130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MM35RIKEN_05170	COG1994	Peptidase M50
MM35RIKEN_05180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MM35RIKEN_05190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MM35RIKEN_05210	COG3874	Sporulation protein YtfJ
MM35RIKEN_05220	COG1686	Belongs to the peptidase S11 family
MM35RIKEN_05230	COG1187	pseudouridine synthase activity
MM35RIKEN_05250	COG2081	HI0933 family
MM35RIKEN_05260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MM35RIKEN_05280	COG0539	negative regulation of cytoplasmic translation
MM35RIKEN_05280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MM35RIKEN_05300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MM35RIKEN_05310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MM35RIKEN_05350	COG0484	heat shock protein binding
MM35RIKEN_05360	COG1561	YicC-like family, N-terminal region
MM35RIKEN_05380	COG0194	GDP metabolic process
MM35RIKEN_05400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MM35RIKEN_05420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MM35RIKEN_05430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MM35RIKEN_05430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MM35RIKEN_05440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MM35RIKEN_05460	COG0515	serine threonine protein kinase
MM35RIKEN_05460	COG2815	serine threonine protein kinase
MM35RIKEN_05470	COG1162	GTPase activity
MM35RIKEN_05500	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MM35RIKEN_05520	COG2155	Conserved Protein
MM35RIKEN_05550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MM35RIKEN_05580	COG0525	valine-tRNA ligase activity
MM35RIKEN_05610	COG2172	sigma factor antagonist activity
MM35RIKEN_05620	COG1191	sigma factor activity
MM35RIKEN_05650	COG0210	DNA helicase
MM35RIKEN_05670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MM35RIKEN_05710	COG0544	peptidyl-prolyl cis-trans isomerase activity
MM35RIKEN_05730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MM35RIKEN_05740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MM35RIKEN_05750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MM35RIKEN_05760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MM35RIKEN_05770	COG1618	nucleotide phosphatase activity, acting on free nucleotides
MM35RIKEN_05780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MM35RIKEN_05790	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MM35RIKEN_05800	COG1940	carbohydrate kinase activity
MM35RIKEN_05810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MM35RIKEN_05820	COG1660	Displays ATPase and GTPase activities
MM35RIKEN_05840	COG1481	regulation of sporulation
MM35RIKEN_05910	COG3854	ATPases associated with a variety of cellular activities
MM35RIKEN_06000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MM35RIKEN_06010	COG1570	exodeoxyribonuclease VII activity
MM35RIKEN_06020	COG1722	exodeoxyribonuclease VII activity
MM35RIKEN_06060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MM35RIKEN_06070	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MM35RIKEN_06080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MM35RIKEN_06090	COG1438	arginine binding
MM35RIKEN_06100	COG0497	DNA recombination
MM35RIKEN_06110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MM35RIKEN_06170	COG4974	Belongs to the 'phage' integrase family
MM35RIKEN_06180	COG3958	Transketolase
MM35RIKEN_06190	COG3959	Transketolase, thiamine diphosphate binding domain
MM35RIKEN_06200	COG4974	Belongs to the 'phage' integrase family
MM35RIKEN_06220	COG0280	phosphate acetyltransferase
MM35RIKEN_06240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MM35RIKEN_06250	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM35RIKEN_06270	COG3546	catalase activity
MM35RIKEN_06350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM35RIKEN_06370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM35RIKEN_06370	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_06380	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_06380	COG1013	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_06380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM35RIKEN_06380	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MM35RIKEN_06390	COG1396	sequence-specific DNA binding
MM35RIKEN_06400	COG1191	sigma factor activity
MM35RIKEN_06420	COG0191	fructose-bisphosphate aldolase activity
MM35RIKEN_06430	COG0205	6-phosphofructokinase activity
MM35RIKEN_06460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MM35RIKEN_06470	COG0217	transcriptional regulatory protein
MM35RIKEN_06480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MM35RIKEN_06490	COG2384	SAM-dependent methyltransferase
MM35RIKEN_06530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MM35RIKEN_06540	COG2255	four-way junction helicase activity
MM35RIKEN_06550	COG0632	four-way junction helicase activity
MM35RIKEN_06560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MM35RIKEN_06580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MM35RIKEN_06590	COG4492	Belongs to the UPF0735 family
MM35RIKEN_06610	COG0617	tRNA 3'-terminal CCA addition
MM35RIKEN_06620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MM35RIKEN_06640	COG0358	DNA primase activity
MM35RIKEN_06650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MM35RIKEN_06670	COG0427	acetyl-CoA hydrolase
MM35RIKEN_06680	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_06680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM35RIKEN_06680	COG1013	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_06680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM35RIKEN_06690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MM35RIKEN_06710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MM35RIKEN_06720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MM35RIKEN_06830	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MM35RIKEN_06860	COG3949	Membrane
MM35RIKEN_06870	COG0280	phosphate acetyltransferase
MM35RIKEN_06880	COG0436	Aminotransferase
MM35RIKEN_06890	COG2502	aspartate--ammonia ligase
MM35RIKEN_06900	COG1489	DNA binding
MM35RIKEN_06920	COG4770	biotin carboxylase activity
MM35RIKEN_06930	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MM35RIKEN_06960	COG0537	adenosine 5'-monophosphoramidase activity
MM35RIKEN_06980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MM35RIKEN_07010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MM35RIKEN_07010	COG1328	CTP reductase activity
MM35RIKEN_07030	COG4869	propanediol catabolic process
MM35RIKEN_07050	COG0583	DNA-binding transcription factor activity
MM35RIKEN_07060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MM35RIKEN_07080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MM35RIKEN_07090	COG0335	large ribosomal subunit rRNA binding
MM35RIKEN_07140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM35RIKEN_07160	COG1131	(ABC) transporter
MM35RIKEN_07180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MM35RIKEN_07190	COG0826	peptidase U32
MM35RIKEN_07200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MM35RIKEN_07220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MM35RIKEN_07230	COG0622	Phosphoesterase
MM35RIKEN_07240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM35RIKEN_07250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM35RIKEN_07300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MM35RIKEN_07320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MM35RIKEN_07330	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MM35RIKEN_07350	COG0604	alcohol dehydrogenase
MM35RIKEN_07360	COG3246	L-lysine catabolic process to acetate
MM35RIKEN_07370	COG1607	acyl-coa hydrolase
MM35RIKEN_07380	COG1193	negative regulation of DNA recombination
MM35RIKEN_07460	COG0372	Belongs to the citrate synthase family
MM35RIKEN_07470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MM35RIKEN_07530	COG3426	butyrate kinase activity
MM35RIKEN_07540	COG2878	Part of a membrane complex involved in electron transport
MM35RIKEN_07570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MM35RIKEN_07600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MM35RIKEN_07620	COG2116	formate transmembrane transporter activity
MM35RIKEN_07630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MM35RIKEN_07660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MM35RIKEN_07670	COG0006	proline dipeptidase activity
MM35RIKEN_07680	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MM35RIKEN_07700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MM35RIKEN_07710	COG0495	leucyl-tRNA aminoacylation
MM35RIKEN_07730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MM35RIKEN_07740	COG0519	Catalyzes the synthesis of GMP from XMP
MM35RIKEN_07750	COG4974	Belongs to the 'phage' integrase family
MM35RIKEN_07790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MM35RIKEN_07840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MM35RIKEN_07940	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_07950	COG2738	Putative neutral zinc metallopeptidase
MM35RIKEN_08000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MM35RIKEN_08010	COG0628	permease
MM35RIKEN_08050	COG1132	(ABC) transporter
MM35RIKEN_08090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM35RIKEN_08110	COG4589	Belongs to the CDS family
MM35RIKEN_08120	COG0204	Acyl-transferase
MM35RIKEN_08180	COG4716	Myosin-crossreactive antigen
MM35RIKEN_08200	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_08210	COG3850	Histidine kinase
MM35RIKEN_08210	COG5002	protein histidine kinase activity
MM35RIKEN_08220	COG1028	Short-chain dehydrogenase reductase Sdr
MM35RIKEN_08410	COG0629	single-stranded DNA binding
MM35RIKEN_08450	COG1396	sequence-specific DNA binding
MM35RIKEN_08710	COG1837	Belongs to the UPF0109 family
MM35RIKEN_08720	COG0228	four-way junction DNA binding
MM35RIKEN_08730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MM35RIKEN_08740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MM35RIKEN_08750	COG0336	Belongs to the RNA methyltransferase TrmD family
MM35RIKEN_08770	COG3064	Membrane
MM35RIKEN_08770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MM35RIKEN_08770	COG3583	domain protein
MM35RIKEN_08810	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MM35RIKEN_08830	COG2860	membrane
MM35RIKEN_08870	COG0583	DNA-binding transcription factor activity
MM35RIKEN_08880	COG1115	amino acid carrier protein
MM35RIKEN_08910	COG2848	UPF0210 protein
MM35RIKEN_08930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MM35RIKEN_08940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MM35RIKEN_08960	COG0534	Mate efflux family protein
MM35RIKEN_08970	COG2226	methyltransferase
MM35RIKEN_08980	COG1757	Na H antiporter
MM35RIKEN_09030	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MM35RIKEN_09100	COG2226	methyltransferase
MM35RIKEN_09110	COG2226	methyltransferase
MM35RIKEN_09250	COG0305	Participates in initiation and elongation during chromosome replication
MM35RIKEN_09300	COG0582	viral genome integration into host DNA
MM35RIKEN_09320	COG0642	Histidine kinase
MM35RIKEN_09330	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_09350	COG1136	(ABC) transporter
MM35RIKEN_09450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MM35RIKEN_09480	COG4496	protein, YerC YecD
MM35RIKEN_09500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MM35RIKEN_09520	COG3481	metal-dependent phosphohydrolase, HD sub domain
MM35RIKEN_09530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MM35RIKEN_09540	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MM35RIKEN_09580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MM35RIKEN_09590	COG1177	transmembrane transport
MM35RIKEN_09600	COG1176	ABC-type spermidine putrescine transport system, permease component I
MM35RIKEN_09610	COG3842	ATPase activity
MM35RIKEN_09620	COG0564	pseudouridine synthase activity
MM35RIKEN_09630	COG1399	metal-binding, possibly nucleic acid-binding protein
MM35RIKEN_09640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MM35RIKEN_09670	COG1160	GTP binding
MM35RIKEN_09680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MM35RIKEN_09710	COG1876	peptidase activity
MM35RIKEN_09730	COG0384	phenazine biosynthesis protein PhzF
MM35RIKEN_09750	COG3608	succinylglutamate desuccinylase aspartoacylase
MM35RIKEN_09750	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MM35RIKEN_09770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MM35RIKEN_09780	COG1943	Transposase
MM35RIKEN_09810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MM35RIKEN_09820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MM35RIKEN_09830	COG0549	Belongs to the carbamate kinase family
MM35RIKEN_09860	COG3845	ABC transporter
MM35RIKEN_09870	COG4603	Belongs to the binding-protein-dependent transport system permease family
MM35RIKEN_09880	COG1079	Belongs to the binding-protein-dependent transport system permease family
MM35RIKEN_09920	COG0564	pseudouridine synthase activity
MM35RIKEN_10000	COG0640	Transcriptional regulator
MM35RIKEN_10120	COG0791	NLP P60 protein
MM35RIKEN_10250	COG1475	DNA binding
MM35RIKEN_10260	COG0740	serine-type endopeptidase activity
MM35RIKEN_10320	COG1131	(ABC) transporter
MM35RIKEN_10350	COG1725	Transcriptional regulator
MM35RIKEN_10360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MM35RIKEN_10370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MM35RIKEN_10380	COG1476	TRANSCRIPTIONal
MM35RIKEN_10390	COG0427	acetyl-CoA hydrolase
MM35RIKEN_10420	COG1461	Dihydroxyacetone kinase
MM35RIKEN_10430	COG0205	6-phosphofructokinase activity
MM35RIKEN_10470	COG0765	amino acid transport
MM35RIKEN_10540	COG0180	Tryptophanyl-tRNA synthetase
MM35RIKEN_10580	COG2200	EAL domain
MM35RIKEN_10660	COG1971	Probably functions as a manganese efflux pump
MM35RIKEN_10680	COG2323	membrane
MM35RIKEN_10690	COG0038	chloride channel
MM35RIKEN_10700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MM35RIKEN_10710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MM35RIKEN_10720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MM35RIKEN_10730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MM35RIKEN_10740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MM35RIKEN_10750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MM35RIKEN_10770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MM35RIKEN_10790	COG0356	it plays a direct role in the translocation of protons across the membrane
MM35RIKEN_10810	COG1611	Belongs to the LOG family
MM35RIKEN_10820	COG0464	growth
MM35RIKEN_10850	COG1477	protein flavinylation
MM35RIKEN_10860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MM35RIKEN_10870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MM35RIKEN_10880	COG2309	aminopeptidase activity
MM35RIKEN_10890	COG0569	domain protein
MM35RIKEN_10900	COG1295	ribonuclease BN
MM35RIKEN_10950	COG4166	transmembrane transport
MM35RIKEN_10970	COG0058	SHG alpha-glucan phosphorylase activity
MM35RIKEN_10980	COG0297	glycogen (starch) synthase activity
MM35RIKEN_10990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MM35RIKEN_11000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MM35RIKEN_11010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MM35RIKEN_11030	COG1760	l-serine dehydratase
MM35RIKEN_11060	COG1966	Carbon starvation protein
MM35RIKEN_11120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MM35RIKEN_11150	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MM35RIKEN_11160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MM35RIKEN_11250	COG0582	viral genome integration into host DNA
MM35RIKEN_11290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MM35RIKEN_11330	COG0436	Aminotransferase
MM35RIKEN_11340	COG1077	Cell shape determining protein MreB Mrl
MM35RIKEN_11360	COG1040	competence protein
MM35RIKEN_11370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MM35RIKEN_11410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MM35RIKEN_11430	COG0697	spore germination
MM35RIKEN_11450	COG0556	nucleotide-excision repair
MM35RIKEN_11460	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
MM35RIKEN_11480	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MM35RIKEN_11490	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MM35RIKEN_11500	COG1394	ATPase activity, coupled to movement of substances
MM35RIKEN_11530	COG2003	Belongs to the UPF0758 family
MM35RIKEN_11580	COG5002	protein histidine kinase activity
MM35RIKEN_11590	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_11600	COG0577	efflux transmembrane transporter activity
MM35RIKEN_11610	COG1136	(ABC) transporter
MM35RIKEN_11630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MM35RIKEN_11650	COG1794	racemase activity, acting on amino acids and derivatives
MM35RIKEN_11680	COG0531	amino acid
MM35RIKEN_11690	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MM35RIKEN_11700	COG4692	amylo-alpha-1,6-glucosidase activity
MM35RIKEN_11770	COG0367	asparagine synthase
MM35RIKEN_11780	COG0504	CTP synthase activity
MM35RIKEN_11790	COG1362	aminopeptidase activity
MM35RIKEN_11800	COG0009	L-threonylcarbamoyladenylate synthase
MM35RIKEN_11820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MM35RIKEN_11840	COG0488	(ABC) transporter
MM35RIKEN_11850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MM35RIKEN_11860	COG1181	Belongs to the D-alanine--D-alanine ligase family
MM35RIKEN_11870	COG0772	Belongs to the SEDS family
MM35RIKEN_11880	COG0802	atpase or kinase
MM35RIKEN_11890	COG1214	PFAM Peptidase M22, glycoprotease
MM35RIKEN_11900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MM35RIKEN_11920	COG1943	Transposase
MM35RIKEN_11930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM35RIKEN_11930	COG0493	'glutamate synthase
MM35RIKEN_11960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MM35RIKEN_11980	COG0662	Cupin 2, conserved barrel domain protein
MM35RIKEN_12060	COG1966	Carbon starvation protein
MM35RIKEN_12120	COG0726	polysaccharide deacetylase
MM35RIKEN_12130	COG0737	Belongs to the 5'-nucleotidase family
MM35RIKEN_12210	COG0671	phosphoesterase, PA-phosphatase related
MM35RIKEN_12240	COG1316	TRANSCRIPTIONal
MM35RIKEN_12330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MM35RIKEN_12360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MM35RIKEN_12370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MM35RIKEN_12380	COG1968	undecaprenyl-diphosphatase activity
MM35RIKEN_12440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MM35RIKEN_12460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MM35RIKEN_12840	COG1024	Enoyl-CoA hydratase
MM35RIKEN_12850	COG1013	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_12850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM35RIKEN_12850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM35RIKEN_12850	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_12890	COG4608	Belongs to the ABC transporter superfamily
MM35RIKEN_12900	COG0444	Belongs to the ABC transporter superfamily
MM35RIKEN_12910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM35RIKEN_12930	COG0747	negative chemotaxis
MM35RIKEN_13020	COG0251	oxidation-reduction process
MM35RIKEN_13030	COG2962	Rard protein
MM35RIKEN_13060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MM35RIKEN_13080	COG0582	viral genome integration into host DNA
MM35RIKEN_13090	COG1475	DNA binding
MM35RIKEN_13430	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_13440	COG5002	protein histidine kinase activity
MM35RIKEN_13490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MM35RIKEN_13500	COG0581	inorganic phosphate transmembrane transporter activity
MM35RIKEN_13510	COG0573	inorganic phosphate transmembrane transporter activity
MM35RIKEN_13520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MM35RIKEN_13530	COG1687	branched-chain amino acid
MM35RIKEN_13540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MM35RIKEN_13550	COG1045	serine acetyltransferase
MM35RIKEN_13580	COG0149	triose-phosphate isomerase activity
MM35RIKEN_13590	COG0126	phosphoglycerate kinase activity
MM35RIKEN_13630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MM35RIKEN_13650	COG0183	Belongs to the thiolase family
MM35RIKEN_13680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MM35RIKEN_13690	COG0527	aspartate kinase activity
MM35RIKEN_13740	COG2313	pseudouridylate synthase activity
MM35RIKEN_13750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MM35RIKEN_13750	COG1522	sequence-specific DNA binding
MM35RIKEN_13760	COG0017	Asparaginyl-tRNA synthetase
MM35RIKEN_13780	COG0318	PFAM AMP-dependent synthetase and ligase
MM35RIKEN_13800	COG3118	belongs to the thioredoxin family
MM35RIKEN_13810	COG0460	homoserine dehydrogenase
MM35RIKEN_13830	COG2357	RelA SpoT domain protein
MM35RIKEN_13840	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_13880	COG1131	(ABC) transporter
MM35RIKEN_13900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MM35RIKEN_13910	COG0456	acetyltransferase
MM35RIKEN_13920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MM35RIKEN_13920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MM35RIKEN_13960	COG0772	Belongs to the SEDS family
MM35RIKEN_13970	COG0768	penicillin binding
MM35RIKEN_13990	COG3859	Proton-coupled thiamine transporter YuaJ
MM35RIKEN_14000	COG2033	superoxide reductase activity
MM35RIKEN_14010	COG1592	Rubrerythrin
MM35RIKEN_14030	COG1342	Belongs to the UPF0251 family
MM35RIKEN_14050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MM35RIKEN_14060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MM35RIKEN_14070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MM35RIKEN_14090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MM35RIKEN_14100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MM35RIKEN_14110	COG0077	Prephenate dehydratase
MM35RIKEN_14110	COG1605	Chorismate mutase
MM35RIKEN_14120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MM35RIKEN_14190	COG1114	Component of the transport system for branched-chain amino acids
MM35RIKEN_14300	COG4603	Belongs to the binding-protein-dependent transport system permease family
MM35RIKEN_14320	COG3845	ABC transporter
MM35RIKEN_14390	COG3620	sequence-specific DNA binding
MM35RIKEN_14400	COG1674	ftsk spoiiie
MM35RIKEN_14410	COG2946	Replication initiation factor
MM35RIKEN_14530	COG0791	NLP P60 protein
MM35RIKEN_14530	COG0741	lytic transglycosylase activity
MM35RIKEN_14540	COG0741	lytic transglycosylase activity
MM35RIKEN_14540	COG0791	NLP P60 protein
MM35RIKEN_14660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MM35RIKEN_14710	COG4974	Belongs to the 'phage' integrase family
MM35RIKEN_14730	COG0833	amino acid
MM35RIKEN_14750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MM35RIKEN_14830	COG1592	Rubrerythrin
MM35RIKEN_14830	COG1773	rubredoxin
MM35RIKEN_14840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MM35RIKEN_14870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MM35RIKEN_14890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MM35RIKEN_14940	COG1194	a g-specific adenine glycosylase
MM35RIKEN_14970	COG0698	ribose 5-phosphate isomerase
MM35RIKEN_14980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MM35RIKEN_14990	COG0484	heat shock protein binding
MM35RIKEN_15000	COG0443	Heat shock 70 kDa protein
MM35RIKEN_15010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MM35RIKEN_15020	COG1420	regulation of RNA biosynthetic process
MM35RIKEN_15030	COG0569	domain protein
MM35RIKEN_15040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MM35RIKEN_15050	COG0534	Mate efflux family protein
MM35RIKEN_15060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM35RIKEN_15070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MM35RIKEN_15100	COG0459	protein refolding
MM35RIKEN_15110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MM35RIKEN_15120	COG1597	lipid kinase activity
MM35RIKEN_15130	COG0116	Belongs to the methyltransferase superfamily
MM35RIKEN_15180	COG3681	Belongs to the UPF0597 family
MM35RIKEN_15210	COG4656	Part of a membrane complex involved in electron transport
MM35RIKEN_15220	COG4658	electron transport chain
MM35RIKEN_15230	COG4659	FMN binding
MM35RIKEN_15240	COG4660	Part of a membrane complex involved in electron transport
MM35RIKEN_15250	COG4657	Part of a membrane complex involved in electron transport
MM35RIKEN_15260	COG1245	4Fe-4S binding domain
MM35RIKEN_15260	COG2878	Part of a membrane complex involved in electron transport
MM35RIKEN_15360	COG1116	anion transmembrane transporter activity
MM35RIKEN_15380	COG1253	flavin adenine dinucleotide binding
MM35RIKEN_15390	COG2011	ABC-type metal ion transport system permease component
MM35RIKEN_15400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MM35RIKEN_15410	COG1464	Belongs to the NlpA lipoprotein family
MM35RIKEN_15430	COG3457	Alanine racemase
MM35RIKEN_15450	COG1757	Na H antiporter
MM35RIKEN_15460	COG1757	Na H antiporter
MM35RIKEN_15470	COG0733	neurotransmitter:sodium symporter activity
MM35RIKEN_15480	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_15490	COG2205	protein histidine kinase activity
MM35RIKEN_15510	COG0446	pyridine nucleotide-disulphide oxidoreductase
MM35RIKEN_15550	COG0445	tRNA wobble uridine modification
MM35RIKEN_15600	COG0673	inositol 2-dehydrogenase activity
MM35RIKEN_15620	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MM35RIKEN_15640	COG0733	neurotransmitter:sodium symporter activity
MM35RIKEN_15650	COG2050	protein possibly involved in aromatic compounds catabolism
MM35RIKEN_15660	COG0628	permease
MM35RIKEN_15690	COG0803	Belongs to the bacterial solute-binding protein 9 family
MM35RIKEN_15690	COG3443	Belongs to the bacterial solute-binding protein 9 family
MM35RIKEN_15710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MM35RIKEN_15730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM35RIKEN_15770	COG0187	DNA topoisomerase II activity
MM35RIKEN_15830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MM35RIKEN_15860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MM35RIKEN_15880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MM35RIKEN_15880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MM35RIKEN_15890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MM35RIKEN_15900	COG1490	D-aminoacyl-tRNA deacylase activity
MM35RIKEN_15920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MM35RIKEN_15930	COG2244	polysaccharide biosynthetic process
MM35RIKEN_15940	COG3956	TIGRFAM MazG family protein
MM35RIKEN_15960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MM35RIKEN_16000	COG1098	S1 RNA binding domain
MM35RIKEN_16040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM35RIKEN_16080	COG1028	Short-chain dehydrogenase reductase Sdr
MM35RIKEN_16090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MM35RIKEN_16100	COG0564	pseudouridine synthase activity
MM35RIKEN_16120	COG0822	iron-sulfur transferase activity
MM35RIKEN_16150	COG0628	permease
MM35RIKEN_16160	COG0095	Lipoate-protein ligase
MM35RIKEN_16190	COG0022	dehydrogenase e1 component
MM35RIKEN_16200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MM35RIKEN_16230	COG2084	Dehydrogenase
MM35RIKEN_16260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MM35RIKEN_16450	COG1484	DNA-dependent DNA replication
MM35RIKEN_16530	COG3584	3D domain protein
MM35RIKEN_16530	COG1388	LysM domain
MM35RIKEN_16640	COG1475	DNA binding
MM35RIKEN_16990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MM35RIKEN_17010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MM35RIKEN_17020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MM35RIKEN_17030	COG1923	regulation of RNA biosynthetic process
MM35RIKEN_17050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MM35RIKEN_17060	COG1799	cell septum assembly
MM35RIKEN_17090	COG1940	carbohydrate kinase activity
MM35RIKEN_17100	COG0574	Belongs to the PEP-utilizing enzyme family
MM35RIKEN_17100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MM35RIKEN_17120	COG1774	PSP1 C-terminal conserved region
MM35RIKEN_17190	COG0481	GTPase activity
MM35RIKEN_17250	COG0708	Exodeoxyribonuclease III
MM35RIKEN_17270	COG0084	hydrolase, TatD family'
MM35RIKEN_17280	COG1847	R3H domain protein
MM35RIKEN_17290	COG0706	membrane insertase activity
MM35RIKEN_17300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MM35RIKEN_17310	COG0594	ribonuclease P activity
MM35RIKEN_17320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MM35RIKEN_17330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MM35RIKEN_17340	COG0592	DNA-directed DNA polymerase activity
MM35RIKEN_17360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MM35RIKEN_17380	COG0187	DNA topoisomerase II activity
MM35RIKEN_17390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MM35RIKEN_17400	COG1720	tRNA m6t6A37 methyltransferase activity
MM35RIKEN_17410	COG0328	RNA-DNA hybrid ribonuclease activity
MM35RIKEN_17420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM35RIKEN_17420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MM35RIKEN_17440	COG0534	Mate efflux family protein
MM35RIKEN_17460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MM35RIKEN_17480	COG1803	Methylglyoxal synthase
MM35RIKEN_17490	COG2894	cell division
MM35RIKEN_17500	COG0357	Ribosomal RNA small subunit methyltransferase G
MM35RIKEN_17510	COG1970	mechanosensitive ion channel activity
MM35RIKEN_17520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MM35RIKEN_17530	COG1475	DNA binding
MM35RIKEN_17540	COG1192	Involved in chromosome partitioning
MM35RIKEN_17560	COG0768	penicillin binding
MM35RIKEN_17580	COG1792	Involved in formation and maintenance of cell shape
MM35RIKEN_17590	COG0424	maF-like protein
MM35RIKEN_17600	COG0756	dUTP diphosphatase activity
MM35RIKEN_17610	COG0826	peptidase U32
MM35RIKEN_17620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MM35RIKEN_17650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MM35RIKEN_17670	COG2264	protein methyltransferase activity
MM35RIKEN_17700	COG1475	DNA binding
MM35RIKEN_17760	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MM35RIKEN_17790	COG1185	polyribonucleotide nucleotidyltransferase activity
MM35RIKEN_17820	COG1725	Transcriptional regulator
MM35RIKEN_17830	COG1131	(ABC) transporter
MM35RIKEN_17890	COG0733	neurotransmitter:sodium symporter activity
MM35RIKEN_17900	COG0646	methionine synthase
MM35RIKEN_17900	COG1410	methionine synthase
MM35RIKEN_17920	COG5012	cobalamin binding
MM35RIKEN_17930	COG1228	amidohydrolase
MM35RIKEN_17960	COG0509	glycine decarboxylation via glycine cleavage system
MM35RIKEN_17970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MM35RIKEN_17980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MM35RIKEN_18050	COG1929	Belongs to the glycerate kinase type-1 family
MM35RIKEN_18080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MM35RIKEN_18100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MM35RIKEN_18120	COG1058	Belongs to the CinA family
MM35RIKEN_18120	COG1546	Belongs to the CinA family
MM35RIKEN_18130	COG0301	tRNA thio-modification
MM35RIKEN_18140	COG0606	chelatase, subunit chli
MM35RIKEN_18150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM35RIKEN_18150	COG1013	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_18150	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM35RIKEN_18150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM35RIKEN_18160	COG0583	DNA-binding transcription factor activity
MM35RIKEN_18210	COG0322	excinuclease ABC activity
MM35RIKEN_18220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MM35RIKEN_18230	COG1733	regulation of RNA biosynthetic process
MM35RIKEN_18240	COG1279	arginine transmembrane transporter activity
MM35RIKEN_18260	COG3858	chitin binding
MM35RIKEN_18260	COG1388	LysM domain
MM35RIKEN_18270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MM35RIKEN_18320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MM35RIKEN_18350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MM35RIKEN_18370	COG1381	Involved in DNA repair and RecF pathway recombination
MM35RIKEN_18390	COG1193	negative regulation of DNA recombination
MM35RIKEN_18410	COG0779	Required for maturation of 30S ribosomal subunits
MM35RIKEN_18420	COG0195	Participates in both transcription termination and antitermination
MM35RIKEN_18430	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MM35RIKEN_18450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MM35RIKEN_18480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MM35RIKEN_18490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MM35RIKEN_18500	COG0196	riboflavin kinase activity
MM35RIKEN_18570	COG1132	(ABC) transporter
MM35RIKEN_18620	COG0629	single-stranded DNA binding
MM35RIKEN_18630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MM35RIKEN_18640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MM35RIKEN_18650	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MM35RIKEN_18670	COG0305	Participates in initiation and elongation during chromosome replication
MM35RIKEN_18680	COG0037	tRNA processing
MM35RIKEN_18690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MM35RIKEN_18770	COG0542	response to heat
MM35RIKEN_18820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MM35RIKEN_18830	COG2002	toxin-antitoxin pair type II binding
MM35RIKEN_18840	COG2715	membrane protein required for spore maturation
MM35RIKEN_18850	COG0700	Nucleoside recognition
MM35RIKEN_18860	COG0018	arginyl-trna synthetase
MM35RIKEN_18880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MM35RIKEN_18920	COG1418	mRNA catabolic process
MM35RIKEN_18930	COG1692	metallophosphoesterase
MM35RIKEN_18940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MM35RIKEN_18950	COG0420	3'-5' exonuclease activity
MM35RIKEN_18960	COG0252	asparaginase activity
MM35RIKEN_19000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MM35RIKEN_19010	COG0088	Forms part of the polypeptide exit tunnel
MM35RIKEN_19020	COG0089	rRNA binding
MM35RIKEN_19030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MM35RIKEN_19040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MM35RIKEN_19070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MM35RIKEN_19080	COG0255	Belongs to the universal ribosomal protein uL29 family
MM35RIKEN_19090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MM35RIKEN_19100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MM35RIKEN_19110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MM35RIKEN_19120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MM35RIKEN_19130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MM35RIKEN_19140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MM35RIKEN_19150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MM35RIKEN_19160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MM35RIKEN_19170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MM35RIKEN_19190	COG0200	Binds to the 23S rRNA
MM35RIKEN_19210	COG0563	adenylate kinase activity
MM35RIKEN_19240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MM35RIKEN_19250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MM35RIKEN_19260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MM35RIKEN_19280	COG0202	RNA polymerase activity
MM35RIKEN_19310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MM35RIKEN_19350	COG1116	anion transmembrane transporter activity
MM35RIKEN_19360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MM35RIKEN_19370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MM35RIKEN_19400	COG0733	neurotransmitter:sodium symporter activity
MM35RIKEN_19420	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_19430	COG5002	protein histidine kinase activity
MM35RIKEN_19440	COG3872	metal-dependent enzyme
MM35RIKEN_19450	COG2890	protein-(glutamine-N5) methyltransferase activity
MM35RIKEN_19460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MM35RIKEN_19470	COG2137	regulation of response to DNA damage stimulus
MM35RIKEN_19480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MM35RIKEN_19500	COG0215	cysteine-tRNA ligase activity
MM35RIKEN_19510	COG0697	spore germination
MM35RIKEN_19540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MM35RIKEN_19550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MM35RIKEN_19580	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_19590	COG5002	protein histidine kinase activity
MM35RIKEN_19600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MM35RIKEN_19610	COG0765	amino acid transport
MM35RIKEN_19620	COG1126	abc transporter atp-binding protein
MM35RIKEN_19630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MM35RIKEN_19640	COG0085	RNA polymerase activity
MM35RIKEN_19650	COG4868	Belongs to the UPF0371 family
MM35RIKEN_19680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MM35RIKEN_19740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MM35RIKEN_19750	COG4120	Belongs to the binding-protein-dependent transport system permease family
MM35RIKEN_19820	COG1686	Belongs to the peptidase S11 family
MM35RIKEN_20090	COG1388	LysM domain
MM35RIKEN_20090	COG0791	NLP P60 protein
MM35RIKEN_20130	COG0551	DNA topoisomerase type I activity
MM35RIKEN_20130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM35RIKEN_20220	COG3843	relaxase mobilization nuclease domain protein
MM35RIKEN_20260	COG0789	Transcriptional regulator
MM35RIKEN_20280	COG1131	(ABC) transporter
MM35RIKEN_20370	COG3617	BRO family, N-terminal domain
MM35RIKEN_20500	COG0741	lytic transglycosylase activity
MM35RIKEN_20500	COG0791	NLP P60 protein
MM35RIKEN_20530	COG0551	DNA topoisomerase type I activity
MM35RIKEN_20530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM35RIKEN_20610	COG4474	Belongs to the UPF0398 family
MM35RIKEN_20630	COG1199	ATP-dependent helicase activity
MM35RIKEN_20660	COG3843	relaxase mobilization nuclease domain protein
MM35RIKEN_20720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MM35RIKEN_20740	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MM35RIKEN_20770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MM35RIKEN_20890	COG3620	sequence-specific DNA binding
MM35RIKEN_21000	COG2732	(Barnase) inhibitor
MM35RIKEN_21010	COG1609	Transcriptional regulator
MM35RIKEN_21030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MM35RIKEN_21040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MM35RIKEN_21060	COG1496	oxidoreductase activity
MM35RIKEN_21070	COG0653	protein targeting
MM35RIKEN_21160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MM35RIKEN_21170	COG0037	tRNA processing
MM35RIKEN_21210	COG0590	tRNA wobble adenosine to inosine editing
MM35RIKEN_21220	COG2385	sporulation resulting in formation of a cellular spore
MM35RIKEN_21230	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_21240	COG5002	protein histidine kinase activity
MM35RIKEN_21250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MM35RIKEN_21290	COG2239	Acts as a magnesium transporter
MM35RIKEN_21300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MM35RIKEN_21320	COG0326	Molecular chaperone. Has ATPase activity
MM35RIKEN_21340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MM35RIKEN_21350	COG0049	tRNA binding
MM35RIKEN_21360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MM35RIKEN_21370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MM35RIKEN_21430	COG1323	Belongs to the UPF0348 family
MM35RIKEN_21440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MM35RIKEN_21450	COG1854	S-ribosylhomocysteine lyase activity
MM35RIKEN_21460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MM35RIKEN_21510	COG1573	uracil-dna glycosylase
MM35RIKEN_21540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MM35RIKEN_21570	COG1187	pseudouridine synthase activity
MM35RIKEN_21580	COG2508	Transcriptional regulator
MM35RIKEN_21600	COG2884	Cell division ATP-binding protein ftsE
MM35RIKEN_21610	COG2177	Part of the ABC transporter FtsEX involved in
MM35RIKEN_21620	COG0739	heme binding
MM35RIKEN_21640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MM35RIKEN_21660	COG0534	Mate efflux family protein
MM35RIKEN_21670	COG0534	Mate efflux family protein
MM35RIKEN_21690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MM35RIKEN_21700	COG0758	DNA mediated transformation
MM35RIKEN_21700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MM35RIKEN_21710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM35RIKEN_21720	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MM35RIKEN_21730	COG0416	fatty acid biosynthetic process
MM35RIKEN_21750	COG0571	ribonuclease III activity
MM35RIKEN_21780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM35RIKEN_21790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MM35RIKEN_21810	COG0745	RESPONSE REGULATOR receiver
MM35RIKEN_21840	COG0523	cobalamin synthesis protein
MM35RIKEN_21860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MM35RIKEN_21870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MM35RIKEN_21880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MM35RIKEN_21910	COG0482	sulfurtransferase activity
MM35RIKEN_21920	COG2205	protein histidine kinase activity
MM35RIKEN_21940	COG2188	Transcriptional regulator
MM35RIKEN_21970	COG1122	ATPase activity
MM35RIKEN_22160	COG3409	Peptidoglycan-binding domain 1 protein
MM35RIKEN_22160	COG3773	Cell wall hydrolase
MM35RIKEN_22170	COG0784	Response regulator, receiver
MM35RIKEN_22170	COG2198	Histidine kinase
MM35RIKEN_22170	COG2205	protein histidine kinase activity
MM35RIKEN_22210	COG2183	response to ionizing radiation
MM35RIKEN_22220	COG0436	Aminotransferase
MM35RIKEN_22270	COG0544	peptidyl-prolyl cis-trans isomerase activity
MM35RIKEN_22300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MM35RIKEN_22310	COG1733	regulation of RNA biosynthetic process
MM35RIKEN_22340	COG3340	Belongs to the peptidase S51 family
MM35RIKEN_22400	COG2002	toxin-antitoxin pair type II binding
MM35RIKEN_22450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MM35RIKEN_22470	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MM35RIKEN_22490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM35RIKEN_22520	COG2002	toxin-antitoxin pair type II binding
MM35RIKEN_22540	COG3853	Toxic anion resistance protein (TelA)
MM35RIKEN_22570	COG1304	FMN binding
MM35RIKEN_22600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MM35RIKEN_22680	COG1136	(ABC) transporter
MM35RIKEN_22740	COG0741	lytic transglycosylase activity
MM35RIKEN_22740	COG0791	NLP P60 protein
MM35RIKEN_22870	COG2946	Replication initiation factor
MM35RIKEN_22890	COG1674	ftsk spoiiie
MM35RIKEN_23020	COG0572	uridine kinase
MM35RIKEN_23040	COG4447	cellulose binding
MM35RIKEN_23070	COG0095	Lipoate-protein ligase
MM35RIKEN_23080	COG0508	dehydrogenase complex catalyzes the overall conversion of
MM35RIKEN_23090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MM35RIKEN_23100	COG0095	Lipoate-protein ligase
MM35RIKEN_23140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MM35RIKEN_23150	COG0765	amino acid transport
MM35RIKEN_23160	COG1126	abc transporter atp-binding protein
MM35RIKEN_23210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MM35RIKEN_23220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MM35RIKEN_23400	COG3764	Sortase (surface protein transpeptidase)
MM35RIKEN_23420	COG1373	ATPase (AAA superfamily
MM35RIKEN_23480	COG0629	single-stranded DNA binding
MM35RIKEN_23620	COG2357	RelA SpoT domain protein
MM35RIKEN_23630	COG0446	pyridine nucleotide-disulphide oxidoreductase
MM35RIKEN_23680	COG1773	rubredoxin
MM35RIKEN_23700	COG2033	superoxide reductase activity
MM35RIKEN_23710	COG1592	Rubrerythrin
MM35RIKEN_23770	COG1131	(ABC) transporter
MM35RIKEN_23790	COG0681	Belongs to the peptidase S26 family
MM35RIKEN_23810	COG0582	viral genome integration into host DNA
MM35RIKEN_23910	COG0714	Associated with various cellular activities
MM35RIKEN_23980	COG1960	acyl-CoA dehydrogenase activity
MM35RIKEN_23990	COG0426	domain, Protein
MM35RIKEN_24010	COG0426	domain, Protein
MM35RIKEN_24040	COG0492	ferredoxin-NADP+ reductase activity
MM35RIKEN_24050	COG3118	belongs to the thioredoxin family
MM35RIKEN_24080	COG1528	Iron-storage protein
MM35RIKEN_24150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MM35RIKEN_24210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MM35RIKEN_24240	COG0582	viral genome integration into host DNA
MM35RIKEN_24250	COG0012	GTP binding
MM35RIKEN_24270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM35RIKEN_24280	COG1120	ATPase activity
MM35RIKEN_24290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity