locus-tag	class	description
VA249_00020	COG0592	DNA-directed DNA polymerase activity
VA249_00040	COG0187	DNA topoisomerase II activity
VA249_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
VA249_00060	COG3977	Valine--pyruvate aminotransferase
VA249_00090	COG2119	membrane
VA249_00110	COG0425	Belongs to the sulfur carrier protein TusA family
VA249_00140	COG0604	alcohol dehydrogenase
VA249_00150	COG0183	Belongs to the thiolase family
VA249_00170	COG1739	Uncharacterized protein family UPF0029
VA249_00180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA249_00230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VA249_00240	COG2104	thiamine diphosphate biosynthetic process
VA249_00270	COG0006	proline dipeptidase activity
VA249_00270	COG0006	proline dipeptidase activity
VA249_00290	COG2814	Major facilitator Superfamily
VA249_00330	COG3220	belongs to the UPF0276 family
VA249_00350	COG0210	DNA helicase
VA249_00360	COG0405	Gamma-glutamyltransferase
VA249_00370	COG1280	lysine exporter protein (LysE YggA)
VA249_00390	COG2962	Rard protein
VA249_00400	COG0514	ATP-dependent DNA helicase (RecQ)
VA249_00420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VA249_00430	COG0248	Ppx GppA phosphatase
VA249_00450	COG3118	belongs to the thioredoxin family
VA249_00480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VA249_00490	COG0633	Ferredoxin
VA249_00520	COG2959	enzyme of heme biosynthesis
VA249_00530	COG1587	Uroporphyrinogen-III synthase
VA249_00560	COG1965	Belongs to the frataxin family
VA249_00570	COG0019	diaminopimelate decarboxylase activity
VA249_00600	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VA249_00610	COG1011	Hydrolase
VA249_00620	COG3148	PFAM DTW domain containing protein
VA249_00650	COG0561	phosphatase activity
VA249_00660	COG2267	carboxylic ester hydrolase activity
VA249_00670	COG1280	lysine exporter protein (LysE YggA)
VA249_00680	COG0640	Transcriptional regulator
VA249_00690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VA249_00790	COG0742	ribosomal rna small subunit methyltransferase
VA249_00800	COG0552	protein localization to endoplasmic reticulum
VA249_00810	COG2884	Cell division ATP-binding protein ftsE
VA249_00820	COG2177	Part of the ABC transporter FtsEX involved in
VA249_00860	COG0705	Rhomboid family
VA249_00870	COG1580	Controls the rotational direction of flagella during chemotaxis
VA249_00880	COG3161	chorismate lyase activity
VA249_00900	COG2937	Belongs to the GPAT DAPAT family
VA249_00930	COG0534	Mate efflux family protein
VA249_00940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA249_01020	COG0582	viral genome integration into host DNA
VA249_01110	COG1486	melibiose metabolic process
VA249_01120	COG2188	Transcriptional regulator
VA249_01170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA249_01190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VA249_01210	COG1072	(Pantothenic acid kinase))
VA249_01220	COG1072	(Pantothenic acid kinase))
VA249_01240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VA249_01250	COG0250	Participates in transcription elongation, termination and antitermination
VA249_01270	COG0081	regulation of translation
VA249_01280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VA249_01310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VA249_01320	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VA249_01330	COG2816	NAD+ diphosphatase activity
VA249_01350	COG1573	uracil-dna glycosylase
VA249_01380	COG1253	flavin adenine dinucleotide binding
VA249_01410	COG0151	Belongs to the GarS family
VA249_01420	COG0151	Belongs to the GarS family
VA249_01430	COG0138	bifunctional purine biosynthesis protein purh
VA249_01440	COG0789	Transcriptional regulator
VA249_01450	COG3710	Transcriptional regulator
VA249_01460	COG0531	amino acid
VA249_01470	COG1982	Orn Lys Arg decarboxylase major
VA249_01490	COG2199	diguanylate cyclase activity
VA249_01500	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VA249_01510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA249_01530	COG0439	Biotin carboxylase
VA249_01540	COG0511	ligase activity, forming carbon-carbon bonds
VA249_01550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VA249_01560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VA249_01590	COG2814	Major facilitator Superfamily
VA249_01600	COG0784	Response regulator, receiver
VA249_01600	COG2205	protein histidine kinase activity
VA249_01600	COG2198	Histidine kinase
VA249_01620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_01640	COG2095	MarC family integral membrane protein
VA249_01660	COG4232	protein-disulfide reductase activity
VA249_01670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VA249_01680	COG1027	Aspartate ammonia-lyase
VA249_01690	COG3030	protein affecting phage T7 exclusion by the F plasmid
VA249_01700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VA249_01710	COG2205	protein histidine kinase activity
VA249_01720	COG0745	RESPONSE REGULATOR receiver
VA249_01730	COG3678	ATP-independent chaperone mediated protein folding
VA249_01760	COG0534	Mate efflux family protein
VA249_01810	COG1509	lysine 2,3-aminomutase activity
VA249_01850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VA249_01860	COG1053	succinate dehydrogenase
VA249_01910	COG4942	peptidase
VA249_01920	COG1045	serine acetyltransferase
VA249_01950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA249_01960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VA249_01990	COG0471	metal ion transport
VA249_02020	COG1162	GTPase activity
VA249_02030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VA249_02040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VA249_02050	COG0802	atpase or kinase
VA249_02070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VA249_02080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VA249_02100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VA249_02110	COG0330	HflC and HflK could
VA249_02120	COG0330	HflC and HflK could
VA249_02130	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VA249_02140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VA249_02150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VA249_02160	COG1017	nitric oxide dioxygenase activity
VA249_02160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA249_02180	COG0557	exoribonuclease II activity
VA249_02190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA249_02200	COG0546	phosphoglycolate phosphatase activity
VA249_02230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VA249_02270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA249_02280	COG3954	Phosphoribulokinase
VA249_02290	COG3089	Belongs to the UPF0270 family
VA249_02300	COG0429	hydrolase of the alpha beta-hydrolase fold
VA249_02320	COG0488	(ABC) transporter
VA249_02330	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_02370	COG1047	Peptidyl-prolyl cis-trans
VA249_02380	COG1446	asparaginase
VA249_02410	COG0545	Peptidyl-prolyl cis-trans isomerase
VA249_02420	COG2964	Protein conserved in bacteria
VA249_02430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VA249_02440	COG2923	Belongs to the DsrF TusC family
VA249_02480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_02520	COG0281	malic enzyme
VA249_02540	COG0626	cystathionine gamma-synthase activity
VA249_02550	COG0527	aspartate kinase activity
VA249_02550	COG0460	homoserine dehydrogenase
VA249_02560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VA249_02580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VA249_02600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VA249_02630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VA249_02630	COG0165	Argininosuccinate lyase
VA249_02640	COG0678	peroxiredoxin activity
VA249_02640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_02660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VA249_02750	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VA249_02760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VA249_02770	COG0360	Binds together with S18 to 16S ribosomal RNA
VA249_02780	COG2965	DNA replication, synthesis of RNA primer
VA249_02800	COG0359	binds to the 23S rRNA
VA249_02830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VA249_02850	COG0432	Pfam Uncharacterised protein family UPF0047
VA249_02880	COG0735	belongs to the Fur family
VA249_02890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA249_02930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VA249_02960	COG3335	DDE superfamily endonuclease
VA249_02990	COG1410	methionine synthase
VA249_02990	COG0646	methionine synthase
VA249_03000	COG0527	aspartate kinase activity
VA249_03010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VA249_03030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VA249_03050	COG2197	response regulator
VA249_03060	COG0629	single-stranded DNA binding
VA249_03070	COG2199	diguanylate cyclase activity
VA249_03070	COG2200	EAL domain
VA249_03110	COG1450	Type ii and iii secretion system protein
VA249_03120	COG3267	Type II secretory pathway component ExeA
VA249_03120	COG3409	Peptidoglycan-binding domain 1 protein
VA249_03140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA249_03160	COG1459	type II secretion system
VA249_03250	COG1077	Cell shape determining protein MreB Mrl
VA249_03260	COG1792	Involved in formation and maintenance of cell shape
VA249_03270	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VA249_03280	COG0424	maF-like protein
VA249_03300	COG3164	Protein of unknown function
VA249_03310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VA249_03320	COG0312	modulator of DNA gyrase
VA249_03330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VA249_03340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VA249_03350	COG0564	pseudouridine synthase activity
VA249_03360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VA249_03370	COG3028	Belongs to the UPF0307 family
VA249_03380	COG0312	modulator of DNA gyrase
VA249_03390	COG2239	Acts as a magnesium transporter
VA249_03400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_03420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_03430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VA249_03450	COG1137	ATPase activity
VA249_03460	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VA249_03480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VA249_03480	COG0517	IMP dehydrogenase activity
VA249_03500	COG1127	ABC transporter
VA249_03510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VA249_03520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VA249_03530	COG2854	intermembrane phospholipid transfer
VA249_03550	COG5007	Belongs to the BolA IbaG family
VA249_03570	COG0204	Acyl-transferase
VA249_03580	COG0251	oxidation-reduction process
VA249_03650	COG0456	acetyltransferase
VA249_03670	COG0525	valine-tRNA ligase activity
VA249_03680	COG2927	DNA polymerase III (CHI subunit)
VA249_03690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VA249_03700	COG0795	lipopolysaccharide-transporting ATPase activity
VA249_03710	COG0795	lipopolysaccharide-transporting ATPase activity
VA249_03750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VA249_03750	COG3153	acetyltransferase
VA249_03770	COG1012	belongs to the aldehyde dehydrogenase family
VA249_03800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VA249_03850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VA249_03860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VA249_03890	COG0762	integral membrane protein
VA249_03900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VA249_03910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VA249_03940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VA249_03950	COG1678	Uncharacterized ACR, COG1678
VA249_03960	COG0189	ligase activity
VA249_03970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VA249_03980	COG2356	endonuclease I
VA249_04020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VA249_04050	COG0126	phosphoglycerate kinase activity
VA249_04060	COG0191	fructose-bisphosphate aldolase activity
VA249_04080	COG0668	transmembrane transport
VA249_04100	COG1279	arginine transmembrane transporter activity
VA249_04110	COG0583	DNA-binding transcription factor activity
VA249_04130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VA249_04150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VA249_04160	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VA249_04170	COG3079	Belongs to the UPF0149 family
VA249_04180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA249_04190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA249_04230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VA249_04240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VA249_04250	COG1595	DNA-templated transcription, initiation
VA249_04280	COG3086	response to oxidative stress
VA249_04320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VA249_04330	COG1381	Involved in DNA repair and RecF pathway recombination
VA249_04340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VA249_04380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VA249_04390	COG3956	TIGRFAM MazG family protein
VA249_04410	COG0148	phosphopyruvate hydratase activity
VA249_04430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VA249_04440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VA249_04490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VA249_04510	COG1546	Belongs to the CinA family
VA249_04520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VA249_04550	COG0527	aspartate kinase activity
VA249_04630	COG3630	sodium ion export across plasma membrane
VA249_04640	COG0511	ligase activity, forming carbon-carbon bonds
VA249_04640	COG5016	pyruvate
VA249_04650	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VA249_04670	COG1238	metal cluster binding
VA249_04680	COG0612	Peptidase, M16
VA249_04710	COG1854	S-ribosylhomocysteine lyase activity
VA249_04720	COG4536	flavin adenine dinucleotide binding
VA249_04730	COG4137	Cytochrome C assembly protein
VA249_04740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VA249_04790	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VA249_04800	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VA249_04810	COG0237	dephospho-CoA kinase activity
VA249_04830	COG1459	type II secretion system
VA249_04840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA249_04860	COG0157	Belongs to the NadC ModD family
VA249_04880	COG2186	Transcriptional regulator
VA249_04890	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VA249_04900	COG0508	dehydrogenase complex catalyzes the overall conversion of
VA249_04910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA249_04940	COG0288	reversible hydration of carbon dioxide
VA249_04950	COG0659	secondary active sulfate transmembrane transporter activity
VA249_04960	COG1131	(ABC) transporter
VA249_04970	COG0842	Transport permease protein
VA249_05000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VA249_05020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VA249_05040	COG1489	DNA binding
VA249_05050	COG1643	Atp-dependent helicase
VA249_05060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VA249_05070	COG1752	Esterase of the alpha-beta hydrolase superfamily
VA249_05090	COG1049	propionate catabolic process, 2-methylcitrate cycle
VA249_05100	COG1929	Belongs to the glycerate kinase type-1 family
VA249_05110	COG2610	gluconate transmembrane transporter activity
VA249_05120	COG3835	regulator
VA249_05150	COG0004	ammonium transporteR
VA249_05160	COG1840	ABC-type Fe3 transport system, periplasmic component
VA249_05180	COG3842	ATPase activity
VA249_05190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA249_05220	COG2971	BadF BadG BcrA BcrD
VA249_05240	COG4608	Belongs to the ABC transporter superfamily
VA249_05250	COG0444	Belongs to the ABC transporter superfamily
VA249_05260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_05280	COG0747	negative chemotaxis
VA249_05290	COG2205	protein histidine kinase activity
VA249_05290	COG0784	Response regulator, receiver
VA249_05310	COG0628	permease
VA249_05320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VA249_05330	COG0316	Belongs to the HesB IscA family
VA249_05360	COG0739	heme binding
VA249_05370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VA249_05390	COG2027	D-alanyl-D-alanine carboxypeptidase
VA249_05400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VA249_05410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VA249_05420	COG1534	Rna-binding protein
VA249_05430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VA249_05440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VA249_05450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VA249_05460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA249_05470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VA249_05480	COG0779	Required for maturation of 30S ribosomal subunits
VA249_05490	COG0195	Participates in both transcription termination and antitermination
VA249_05530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VA249_05540	COG1185	polyribonucleotide nucleotidyltransferase activity
VA249_05560	COG1846	Transcriptional regulator
VA249_05570	COG0534	Mate efflux family protein
VA249_05580	COG0826	peptidase U32
VA249_05590	COG0826	peptidase U32
VA249_05610	COG3154	lipid carrier protein
VA249_05620	COG3153	acetyltransferase
VA249_05660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VA249_05680	COG0084	hydrolase, TatD family'
VA249_05690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_05710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VA249_05730	COG0813	purine-nucleoside phosphorylase activity
VA249_05750	COG0560	Phosphoserine phosphatase
VA249_05770	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VA249_05780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_05790	COG1022	Amp-dependent synthetase and ligase
VA249_05810	COG0583	DNA-binding transcription factor activity
VA249_05820	COG1609	Transcriptional regulator
VA249_05830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA249_05860	COG2017	converts alpha-aldose to the beta-anomer
VA249_05870	COG1609	Transcriptional regulator
VA249_05910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VA249_05920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VA249_05930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VA249_05950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VA249_05960	COG3257	ureidoglycine aminohydrolase activity
VA249_05970	COG0549	Belongs to the carbamate kinase family
VA249_05980	COG0583	DNA-binding transcription factor activity
VA249_05990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VA249_06000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VA249_06020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VA249_06030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VA249_06050	COG1301	dicarboxylic acid transport
VA249_06060	COG1953	Uracil, thiamine, allantoin
VA249_06090	COG3960	tartronate-semialdehyde synthase activity
VA249_06100	COG3622	Belongs to the hyi family
VA249_06110	COG2084	Dehydrogenase
VA249_06120	COG1929	Belongs to the glycerate kinase type-1 family
VA249_06130	COG2171	N-acyltransferase activity
VA249_06160	COG3141	response to X-ray
VA249_06190	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VA249_06200	COG1074	ATP-dependent DNA helicase activity
VA249_06210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VA249_06220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VA249_06220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VA249_06240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VA249_06250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VA249_06260	COG2166	iron-sulfur cluster assembly
VA249_06270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VA249_06280	COG0693	protein deglycase activity
VA249_06290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VA249_06300	COG3248	Nucleoside-binding outer membrane protein
VA249_06330	COG1595	DNA-templated transcription, initiation
VA249_06410	COG0271	Belongs to the BolA IbaG family
VA249_06460	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VA249_06480	COG1477	protein flavinylation
VA249_06510	COG0840	transmembrane signaling receptor activity
VA249_06520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VA249_06530	COG0514	ATP-dependent DNA helicase (RecQ)
VA249_06540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VA249_06560	COG0733	neurotransmitter:sodium symporter activity
VA249_06610	COG1720	tRNA m6t6A37 methyltransferase activity
VA249_06620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VA249_06670	COG3098	single-species biofilm formation
VA249_06680	COG0564	pseudouridine synthase activity
VA249_06710	COG0024	Methionine aminopeptidase
VA249_06730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VA249_06760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VA249_06770	COG0575	Belongs to the CDS family
VA249_06790	COG0750	zinc metalloprotease
VA249_06810	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VA249_06820	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA249_06870	COG0587	DNA-directed DNA polymerase activity
VA249_06910	COG0347	Belongs to the P(II) protein family
VA249_06940	COG0741	lytic transglycosylase activity
VA249_06940	COG1388	LysM domain
VA249_06950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VA249_06960	COG2226	methyltransferase
VA249_06980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VA249_07010	COG1960	acyl-CoA dehydrogenase activity
VA249_07020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VA249_07030	COG0121	glutamine amidotransferase
VA249_07050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VA249_07060	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VA249_07070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VA249_07080	COG2233	PERMEase
VA249_07120	COG1393	Belongs to the ArsC family
VA249_07130	COG4783	chaperone-mediated protein folding
VA249_07160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VA249_07170	COG2716	regulation of RNA biosynthetic process
VA249_07180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VA249_07190	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VA249_07230	COG1393	Belongs to the ArsC family
VA249_07460	COG2837	iron assimilation
VA249_07470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_07480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_07490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_07500	COG1334	flagellar protein FlaG
VA249_07510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VA249_07530	COG1516	flagellar protein fliS
VA249_07570	COG1677	Flagellar hook-basal body complex protein FliE
VA249_07590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VA249_07690	COG1987	bacterial-type flagellum assembly
VA249_07700	COG1684	flagellar biosynthetic protein fliR
VA249_07770	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VA249_07780	COG0643	Histidine kinase
VA249_07780	COG0784	Response regulator, receiver
VA249_07780	COG2198	Histidine kinase
VA249_07790	COG2201	protein-glutamate methylesterase activity
VA249_07800	COG1192	Involved in chromosome partitioning
VA249_07820	COG0835	chemotaxis
VA249_07840	COG4133	protoheme IX ABC transporter activity
VA249_07850	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VA249_07860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VA249_07890	COG1138	Cytochrome C-type biogenesis protein
VA249_07900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VA249_07920	COG3088	subunit of a heme lyase
VA249_07920	COG4235	cytochrome complex assembly
VA249_07930	COG2853	Lipoprotein
VA249_07980	COG0183	Belongs to the thiolase family
VA249_07990	COG1024	Enoyl-CoA hydratase
VA249_07990	COG1250	3-hydroxyacyl-CoA dehydrogenase
VA249_08020	COG2062	phosphohistidine phosphatase, SixA
VA249_08030	COG2840	Smr protein MutS2
VA249_08040	COG2890	protein-(glutamine-N5) methyltransferase activity
VA249_08050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VA249_08060	COG2860	membrane
VA249_08070	COG3101	peptidyl-lysine hydroxylation
VA249_08110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VA249_08120	COG0583	DNA-binding transcription factor activity
VA249_08130	COG4771	TonB-dependent receptor
VA249_08170	COG1263	PTS System
VA249_08170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_08180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_08190	COG1621	beta-fructofuranosidase activity
VA249_08200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VA249_08210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VA249_08250	COG0285	dihydrofolate synthase activity
VA249_08260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VA249_08270	COG1286	toxin biosynthetic process
VA249_08280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VA249_08290	COG0583	DNA-binding transcription factor activity
VA249_08300	COG0745	RESPONSE REGULATOR receiver
VA249_08310	COG2832	Protein of unknown function (DUF454)
VA249_08330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VA249_08340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VA249_08350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VA249_08360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VA249_08380	COG2983	Belongs to the UPF0260 family
VA249_08390	COG2261	transglycosylase associated protein
VA249_08400	COG2985	domain, Protein
VA249_08410	COG2985	domain, Protein
VA249_08420	COG0076	glutamate decarboxylase activity
VA249_08430	COG0668	transmembrane transport
VA249_08460	COG1522	sequence-specific DNA binding
VA249_08470	COG1946	Acyl-CoA thioesterase
VA249_08480	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VA249_08510	COG3706	GGDEF domain
VA249_08520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA249_08530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VA249_08540	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VA249_08550	COG0517	IMP dehydrogenase activity
VA249_08550	COG0516	GMP reductase activity
VA249_08610	COG0537	adenosine 5'-monophosphoramidase activity
VA249_08670	COG1252	NADH dehydrogenase
VA249_08700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VA249_08720	COG4591	ABC-type transport system involved in lipoprotein release permease component
VA249_08730	COG1136	(ABC) transporter
VA249_08740	COG4591	ABC-type transport system involved in lipoprotein release permease component
VA249_08770	COG1132	(ABC) transporter
VA249_08820	COG3293	Transposase
VA249_08830	COG2719	SpoVR family
VA249_08840	COG2718	Belongs to the UPF0229 family
VA249_08850	COG2766	serine protein kinase
VA249_08880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VA249_08900	COG1882	Formate acetyltransferase
VA249_08970	COG0708	Exodeoxyribonuclease III
VA249_08990	COG3923	Primosomal replication protein n
VA249_09000	COG0730	response to heat
VA249_09010	COG1199	ATP-dependent helicase activity
VA249_09030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VA249_09040	COG1187	pseudouridine synthase activity
VA249_09060	COG1278	Cold shock
VA249_09080	COG0542	response to heat
VA249_09090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VA249_09100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VA249_09150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VA249_09170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VA249_09180	COG0297	glycogen (starch) synthase activity
VA249_09220	COG3070	regulator of competence-specific genes
VA249_09250	COG3381	protein complex oligomerization
VA249_09260	COG0745	RESPONSE REGULATOR receiver
VA249_09270	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VA249_09280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA249_09290	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VA249_09300	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VA249_09310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VA249_09350	COG4067	protein conserved in archaea
VA249_09350	COG0189	ligase activity
VA249_09360	COG0500	methyltransferase
VA249_09370	COG4106	trans-aconitate 2-methyltransferase activity
VA249_09380	COG1801	Protein of unknown function DUF72
VA249_09390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VA249_09400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VA249_09410	COG0632	four-way junction helicase activity
VA249_09430	COG1271	oxidase subunit
VA249_09440	COG1294	oxidase, subunit
VA249_09460	COG0824	Thioesterase
VA249_09470	COG0811	peptide transport
VA249_09500	COG0823	Involved in the tonB-independent uptake of proteins
VA249_09510	COG2885	chlorophyll binding
VA249_09520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VA249_09530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VA249_09560	COG5002	protein histidine kinase activity
VA249_09560	COG0784	Response regulator, receiver
VA249_09620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VA249_09630	COG1397	ADP-ribosylglycohydrolase
VA249_09780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_09790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_09840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_09880	COG0697	spore germination
VA249_09890	COG2176	DNA-directed DNA polymerase activity
VA249_09900	COG0517	IMP dehydrogenase activity
VA249_09910	COG3293	Transposase
VA249_09920	COG2186	Transcriptional regulator
VA249_09930	COG2186	Transcriptional regulator
VA249_09940	COG0534	Mate efflux family protein
VA249_09980	COG1917	Cupin 2, conserved barrel domain protein
VA249_09990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_10000	COG0800	Aldolase
VA249_10020	COG3293	Transposase
VA249_10040	COG2084	Dehydrogenase
VA249_10070	COG0583	DNA-binding transcription factor activity
VA249_10090	COG0686	Belongs to the AlaDH PNT family
VA249_10110	COG1674	ftsk spoiiie
VA249_10120	COG1674	ftsk spoiiie
VA249_10130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VA249_10140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VA249_10160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VA249_10190	COG0156	8-amino-7-oxononanoate synthase activity
VA249_10270	COG0300	oxidoreductase activity
VA249_10300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VA249_10330	COG2268	Band 7 protein
VA249_10350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VA249_10370	COG0482	sulfurtransferase activity
VA249_10390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_10400	COG2916	Histone family protein nucleoid-structuring protein H-NS
VA249_10410	COG1757	Na H antiporter
VA249_10430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VA249_10440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VA249_10450	COG0131	Imidazoleglycerol-phosphate dehydratase
VA249_10450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VA249_10460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VA249_10470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VA249_10490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VA249_10490	COG0140	phosphoribosyl-ATP diphosphatase activity
VA249_10500	COG3012	SEC-C Motif Domain Protein
VA249_10510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VA249_10520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA249_10530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VA249_10540	COG0215	cysteine-tRNA ligase activity
VA249_10550	COG1435	thymidine kinase activity
VA249_10560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VA249_10610	COG2116	formate transmembrane transporter activity
VA249_10630	COG0390	transport system, permease component
VA249_10640	COG4459	periplasmic nitrate reductase
VA249_10650	COG3005	denitrification pathway
VA249_10660	COG0243	molybdopterin cofactor binding
VA249_10690	COG1227	inorganic diphosphatase activity
VA249_10710	COG4172	Belongs to the ABC transporter superfamily
VA249_10730	COG4171	peptide transport system, permease
VA249_10740	COG4168	peptide transport system, permease
VA249_10760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VA249_10770	COG1842	Phage shock protein A
VA249_10810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_10820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_10840	COG2818	Glycosylase
VA249_10850	COG0626	cystathionine gamma-synthase activity
VA249_10870	COG0733	neurotransmitter:sodium symporter activity
VA249_10890	COG0564	pseudouridine synthase activity
VA249_10910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA249_10920	COG1151	hydroxylamine reductase activity
VA249_10930	COG3604	Transcriptional regulator
VA249_10950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VA249_10960	COG4136	ATPase activity
VA249_10970	COG4135	transport system, permease component
VA249_10980	COG4134	Bacterial extracellular solute-binding protein
VA249_10990	COG0398	Pfam SNARE associated Golgi protein
VA249_11010	COG0493	'glutamate synthase
VA249_11070	COG0737	Belongs to the 5'-nucleotidase family
VA249_11120	COG1061	Type III restriction enzyme res subunit
VA249_11130	COG1187	pseudouridine synthase activity
VA249_11140	COG2814	Major facilitator Superfamily
VA249_11160	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_11180	COG1609	Transcriptional regulator
VA249_11190	COG0702	epimerase
VA249_11220	COG4181	ATPase activity
VA249_11280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VA249_11300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_11320	COG1737	Transcriptional regulator
VA249_11330	COG0076	glutamate decarboxylase activity
VA249_11350	COG2431	L-lysine efflux transmembrane transporter activity
VA249_11390	COG3070	regulator of competence-specific genes
VA249_11420	COG4191	Histidine kinase
VA249_11420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_11440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VA249_11460	COG3706	GGDEF domain
VA249_11490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VA249_11500	COG4988	ABC transporter
VA249_11510	COG0492	ferredoxin-NADP+ reductase activity
VA249_11540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VA249_11560	COG3706	GGDEF domain
VA249_11570	COG0471	metal ion transport
VA249_11580	COG2949	membrane
VA249_11600	COG1643	Atp-dependent helicase
VA249_11620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VA249_11690	COG0277	FAD linked oxidase domain protein
VA249_11690	COG0247	lactate metabolic process
VA249_11720	COG2986	histidine ammonia-lyase
VA249_11730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VA249_11740	COG0010	Belongs to the arginase family
VA249_11790	COG1960	acyl-CoA dehydrogenase activity
VA249_11800	COG3706	GGDEF domain
VA249_11810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VA249_11830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VA249_11850	COG0393	Putative heavy-metal-binding
VA249_11880	COG0072	phenylalanine-tRNA ligase activity
VA249_11880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VA249_11940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VA249_11950	COG1643	Atp-dependent helicase
VA249_11970	COG0534	Mate efflux family protein
VA249_11980	COG2113	Glycine betaine
VA249_11990	COG4176	ABC-type proline glycine betaine transport system permease component
VA249_12030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_12040	COG0456	acetyltransferase
VA249_12050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VA249_12060	COG0662	Cupin 2, conserved barrel domain protein
VA249_12070	COG0527	aspartate kinase activity
VA249_12080	COG0583	DNA-binding transcription factor activity
VA249_12090	COG0702	epimerase
VA249_12120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_12160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VA249_12170	COG0363	glucosamine-6-phosphate deaminase activity
VA249_12180	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VA249_12330	COG3284	Transcriptional regulator
VA249_12340	COG1012	belongs to the aldehyde dehydrogenase family
VA249_12360	COG2358	TRAP transporter, solute receptor (TAXI family
VA249_12370	COG0730	response to heat
VA249_12380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VA249_12390	COG2186	Transcriptional regulator
VA249_12400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VA249_12410	COG0372	Belongs to the citrate synthase family
VA249_12430	COG2828	Protein conserved in bacteria
VA249_12470	COG0561	phosphatase activity
VA249_12480	COG0602	queuosine metabolic process
VA249_12570	COG1254	Belongs to the acylphosphatase family
VA249_12580	COG2920	part of a sulfur-relay system
VA249_12590	COG0670	Belongs to the BI1 family
VA249_12600	COG1126	abc transporter atp-binding protein
VA249_12610	COG0765	amino acid transport
VA249_12620	COG4597	amino acid ABC transporter
VA249_12630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_12660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA249_12710	COG3008	intermembrane lipid transfer
VA249_12720	COG2995	paraquat-inducible protein a
VA249_12730	COG1132	(ABC) transporter
VA249_12740	COG1956	GAF domain-containing protein
VA249_12760	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VA249_12790	COG0308	aminopeptidase N
VA249_12800	COG2902	Dehydrogenase
VA249_12810	COG0167	dihydroorotate dehydrogenase activity
VA249_12850	COG0488	(ABC) transporter
VA249_12880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VA249_12890	COG1067	ATP-dependent peptidase activity
VA249_12900	COG3120	sequence-specific DNA binding
VA249_12940	COG2205	protein histidine kinase activity
VA249_12940	COG0784	Response regulator, receiver
VA249_12970	COG3278	Belongs to the heme-copper respiratory oxidase family
VA249_13000	COG2010	Cytochrome c
VA249_13020	COG2217	Heavy metal translocating P-type atpase
VA249_13050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA249_13060	COG0589	response to stress
VA249_13110	COG3842	ATPase activity
VA249_13130	COG1177	transmembrane transport
VA249_13150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VA249_13160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VA249_13190	COG0437	4 iron, 4 sulfur cluster binding
VA249_13200	COG0243	molybdopterin cofactor binding
VA249_13200	COG3383	formate dehydrogenase (NAD+) activity
VA249_13220	COG3381	protein complex oligomerization
VA249_13260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VA249_13270	COG0488	(ABC) transporter
VA249_13300	COG4191	Histidine kinase
VA249_13340	COG3842	ATPase activity
VA249_13360	COG0303	'Molybdopterin
VA249_13380	COG1940	carbohydrate kinase activity
VA249_13390	COG3148	PFAM DTW domain containing protein
VA249_13420	COG0791	NLP P60 protein
VA249_13440	COG3706	GGDEF domain
VA249_13450	COG2201	protein-glutamate methylesterase activity
VA249_13460	COG3001	Fructosamine kinase
VA249_13480	COG0307	riboflavin synthase, alpha
VA249_13490	COG0534	Mate efflux family protein
VA249_13530	COG3064	Membrane
VA249_13540	COG0110	maltose O-acetyltransferase activity
VA249_13570	COG0697	spore germination
VA249_13580	COG3247	response to pH
VA249_13590	COG0668	transmembrane transport
VA249_13600	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
VA249_13630	COG0784	Response regulator, receiver
VA249_13630	COG2205	protein histidine kinase activity
VA249_13750	COG0110	maltose O-acetyltransferase activity
VA249_13760	COG0438	transferase activity, transferring glycosyl groups
VA249_13780	COG0438	transferase activity, transferring glycosyl groups
VA249_13800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VA249_13870	COG0625	glutathione transferase activity
VA249_13890	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VA249_14010	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA249_14050	COG0583	DNA-binding transcription factor activity
VA249_14060	COG2814	Major facilitator Superfamily
VA249_14080	COG0583	DNA-binding transcription factor activity
VA249_14190	COG1175	transmembrane transport
VA249_14200	COG1176	ABC-type spermidine putrescine transport system, permease component I
VA249_14210	COG3842	ATPase activity
VA249_14220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VA249_14230	COG2423	ornithine cyclodeaminase activity
VA249_14250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VA249_14260	COG3938	Belongs to the proline racemase family
VA249_14330	COG0784	Response regulator, receiver
VA249_14330	COG2205	protein histidine kinase activity
VA249_14350	COG1451	nucleotide metabolic process
VA249_14370	COG0583	DNA-binding transcription factor activity
VA249_14440	COG1115	amino acid carrier protein
VA249_14450	COG1280	lysine exporter protein (LysE YggA)
VA249_14460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VA249_14470	COG1560	Kdo2-lipid A biosynthetic process
VA249_14480	COG1280	lysine exporter protein (LysE YggA)
VA249_14490	COG0531	amino acid
VA249_14530	COG3063	Type IV pilus biogenesis stability protein PilW
VA249_14550	COG4139	cobalamin transport
VA249_14600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VA249_14620	COG0702	epimerase
VA249_14640	COG2205	protein histidine kinase activity
VA249_14640	COG0784	Response regulator, receiver
VA249_14780	COG2205	protein histidine kinase activity
VA249_14780	COG0784	Response regulator, receiver
VA249_14800	COG2188	Transcriptional regulator
VA249_14810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_14810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_14810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_14820	COG0383	alpha-mannosidase activity
VA249_14830	COG1482	cell wall glycoprotein biosynthetic process
VA249_14860	COG2925	Exonuclease
VA249_14880	COG1346	cytolysis
VA249_14890	COG1346	cytolysis
VA249_14900	COG0295	cytidine deaminase activity
VA249_14940	COG0776	regulation of translation
VA249_14960	COG3706	GGDEF domain
VA249_14980	COG0443	Heat shock 70 kDa protein
VA249_14990	COG0443	Heat shock 70 kDa protein
VA249_15020	COG1132	(ABC) transporter
VA249_15030	COG1132	(ABC) transporter
VA249_15060	COG3437	response regulator, receiver
VA249_15070	COG0814	amino acid
VA249_15100	COG0861	Integral membrane protein TerC family
VA249_15120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VA249_15130	COG1328	CTP reductase activity
VA249_15140	COG1280	lysine exporter protein (LysE YggA)
VA249_15160	COG5001	Diguanylate cyclase
VA249_15180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_15180	COG4191	Histidine kinase
VA249_15190	COG0471	metal ion transport
VA249_15210	COG0456	acetyltransferase
VA249_15290	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_15310	COG3293	Transposase
VA249_15430	COG3293	Transposase
VA249_15450	COG2944	sequence-specific DNA binding
VA249_15460	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VA249_15550	COG3293	Transposase
VA249_15590	COG0494	nUDIX hydrolase
VA249_15720	COG0456	acetyltransferase
VA249_15880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA249_15910	COG3106	COG3106 Predicted ATPase
VA249_15940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VA249_15950	COG0494	nUDIX hydrolase
VA249_15960	COG0814	amino acid
VA249_15970	COG1760	l-serine dehydratase
VA249_15990	COG0720	synthase
VA249_16000	COG0017	Asparaginyl-tRNA synthetase
VA249_16030	COG1448	Aminotransferase
VA249_16220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VA249_16260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VA249_16280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_16350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VA249_16380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VA249_16390	COG3108	Peptidase M15
VA249_16400	COG2989	Protein conserved in bacteria
VA249_16410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VA249_16460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA249_16470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VA249_16480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VA249_16520	COG0287	Prephenate dehydrogenase
VA249_16530	COG0019	diaminopimelate decarboxylase activity
VA249_16570	COG0322	excinuclease ABC activity
VA249_16580	COG2197	response regulator
VA249_16590	COG0417	DNA replication proofreading
VA249_16630	COG1187	pseudouridine synthase activity
VA249_16640	COG0009	L-threonylcarbamoyladenylate synthase
VA249_16650	COG0613	PHP domain protein
VA249_16660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VA249_16670	COG0512	Glutamine amidotransferase of anthranilate synthase
VA249_16690	COG0134	indole-3-glycerol-phosphate synthase activity
VA249_16690	COG0135	phosphoribosylanthranilate isomerase activity
VA249_16710	COG0159	tryptophan synthase activity
VA249_16720	COG1301	dicarboxylic acid transport
VA249_16740	COG1607	acyl-coa hydrolase
VA249_16750	COG2350	Protein conserved in bacteria
VA249_16770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VA249_16780	COG0583	DNA-binding transcription factor activity
VA249_16820	COG1032	radical SAM domain protein
VA249_16830	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA249_16860	COG2964	Protein conserved in bacteria
VA249_16870	COG0840	transmembrane signaling receptor activity
VA249_16890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VA249_16900	COG0463	Glycosyl transferase, family 2
VA249_16910	COG0745	RESPONSE REGULATOR receiver
VA249_16920	COG3850	Histidine kinase
VA249_16920	COG5002	protein histidine kinase activity
VA249_17020	COG3118	belongs to the thioredoxin family
VA249_17030	COG4232	protein-disulfide reductase activity
VA249_17060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VA249_17070	COG2211	Major facilitator Superfamily
VA249_17090	COG4580	involved in the transport of maltose and maltodextrins
VA249_17110	COG3250	beta-galactosidase activity
VA249_17120	COG1609	Transcriptional regulator
VA249_17130	COG2995	paraquat-inducible protein a
VA249_17140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VA249_17140	COG3008	intermembrane lipid transfer
VA249_17150	COG3009	Protein conserved in bacteria
VA249_17190	COG4166	transmembrane transport
VA249_17210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VA249_17220	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VA249_17240	COG0539	negative regulation of cytoplasmic translation
VA249_17250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VA249_17260	COG0616	signal peptide processing
VA249_17270	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_17310	COG0835	chemotaxis
VA249_17310	COG0784	Response regulator, receiver
VA249_17320	COG1940	carbohydrate kinase activity
VA249_17330	COG0469	pyruvate kinase activity
VA249_17340	COG4667	esterase of the alpha-beta hydrolase superfamily
VA249_17370	COG1263	PTS System
VA249_17370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_17380	COG0084	hydrolase, TatD family'
VA249_17410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VA249_17470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VA249_17490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VA249_17500	COG1399	metal-binding, possibly nucleic acid-binding protein
VA249_17510	COG0424	maF-like protein
VA249_17520	COG0564	pseudouridine synthase activity
VA249_17530	COG1530	ribonuclease E activity
VA249_17540	COG0659	secondary active sulfate transmembrane transporter activity
VA249_17550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VA249_17560	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VA249_17570	COG2801	Transposase and inactivated derivatives
VA249_17580	COG2982	Protein involved in outer membrane biogenesis
VA249_17590	COG0572	uridine kinase
VA249_17630	COG2186	Transcriptional regulator
VA249_17650	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VA249_17660	COG3012	SEC-C Motif Domain Protein
VA249_17660	COG3318	Belongs to the UPF0149 family
VA249_17670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA249_17700	COG3706	GGDEF domain
VA249_17710	COG0366	Alpha amylase catalytic
VA249_17720	COG1122	ATPase activity
VA249_17730	COG4120	Belongs to the binding-protein-dependent transport system permease family
VA249_17770	COG0280	phosphate acetyltransferase
VA249_17770	COG0857	belongs to the CobB CobQ family
VA249_17780	COG3174	membrane
VA249_17790	COG0435	Glutathione S-transferase
VA249_17830	COG0444	Belongs to the ABC transporter superfamily
VA249_17840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_17850	COG0601	transmembrane transport
VA249_17870	COG0314	molybdopterin synthase activity
VA249_17880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VA249_17900	COG0521	Mo-molybdopterin cofactor biosynthetic process
VA249_17910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VA249_17920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VA249_17930	COG2198	Histidine kinase
VA249_17940	COG2204	response regulator
VA249_17950	COG0556	nucleotide-excision repair
VA249_17960	COG1882	Formate acetyltransferase
VA249_17970	COG4657	Part of a membrane complex involved in electron transport
VA249_17990	COG4656	Part of a membrane complex involved in electron transport
VA249_18000	COG4658	electron transport chain
VA249_18010	COG4659	FMN binding
VA249_18020	COG4660	Part of a membrane complex involved in electron transport
VA249_18030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VA249_18090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VA249_18110	COG0784	Response regulator, receiver
VA249_18110	COG2205	protein histidine kinase activity
VA249_18170	COG0346	lactoylglutathione lyase activity
VA249_18190	COG2885	chlorophyll binding
VA249_18210	COG2056	Na+-H+ antiporter family
VA249_18250	COG3293	Transposase
VA249_18260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_18280	COG1621	beta-fructofuranosidase activity
VA249_18300	COG3842	ATPase activity
VA249_18310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA249_18320	COG1554	hydrolase, family 65, central catalytic
VA249_18330	COG0395	ABC-type sugar transport system, permease component
VA249_18340	COG1175	transmembrane transport
VA249_18460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VA249_18500	COG1012	belongs to the aldehyde dehydrogenase family
VA249_18500	COG1454	alcohol dehydrogenase
VA249_18510	COG2095	MarC family integral membrane protein
VA249_18520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA249_18530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VA249_18540	COG1757	Na H antiporter
VA249_18590	COG3083	sulfuric ester hydrolase activity
VA249_18600	COG0123	including yeast histone deacetylase and acetoin utilization protein
VA249_18610	COG4948	Mandelate Racemase Muconate Lactonizing
VA249_18630	COG2721	sulfolactate sulfo-lyase activity
VA249_18660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VA249_18670	COG0778	Nitroreductase
VA249_18680	COG1902	pentaerythritol trinitrate reductase activity
VA249_18680	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA249_18690	COG0616	signal peptide processing
VA249_18700	COG0252	asparaginase activity
VA249_18710	COG3139	Protein of unknown function (DUF1315)
VA249_18730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_18740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VA249_18760	COG2226	methyltransferase
VA249_18800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_18810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_18850	COG0477	Major facilitator Superfamily
VA249_18860	COG2855	membrane
VA249_18880	COG0318	PFAM AMP-dependent synthetase and ligase
VA249_18900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VA249_18910	COG0596	Alpha beta hydrolase
VA249_18930	COG1169	isochorismate synthase
VA249_18940	COG0436	Aminotransferase
VA249_18950	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VA249_18990	COG1555	photosystem II stabilization
VA249_19000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA249_19010	COG0776	regulation of translation
VA249_19020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VA249_19030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VA249_19090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA249_19100	COG0569	domain protein
VA249_19110	COG0513	Belongs to the DEAD box helicase family
VA249_19120	COG1253	flavin adenine dinucleotide binding
VA249_19300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_19320	COG2951	lytic endotransglycosylase activity
VA249_19350	COG2894	cell division
VA249_19360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VA249_19370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VA249_19380	COG0318	PFAM AMP-dependent synthetase and ligase
VA249_19390	COG0596	Alpha beta hydrolase
VA249_19420	COG1214	PFAM Peptidase M22, glycoprotease
VA249_19430	COG1199	ATP-dependent helicase activity
VA249_19440	COG0788	formyltetrahydrofolate deformylase activity
VA249_19450	COG3102	Protein conserved in bacteria
VA249_19500	COG1918	ferrous iron import across plasma membrane
VA249_19510	COG4977	sequence-specific DNA binding
VA249_19520	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VA249_19530	COG1121	(ABC) transporter
VA249_19540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VA249_19570	COG0508	dehydrogenase complex catalyzes the overall conversion of
VA249_19580	COG0567	Dehydrogenase, E1 component
VA249_19590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VA249_19600	COG1053	succinate dehydrogenase
VA249_19610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VA249_19640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VA249_19660	COG0033	Phosphoglucomutase
VA249_19670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VA249_19680	COG0596	Alpha beta hydrolase
VA249_19700	COG0716	FMN binding
VA249_19720	COG0735	belongs to the Fur family
VA249_19740	COG1263	PTS System
VA249_19740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_19740	COG2190	(PTS) system
VA249_19750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VA249_19760	COG1846	Transcriptional regulator
VA249_19760	COG1940	carbohydrate kinase activity
VA249_19770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VA249_19770	COG4651	solute:proton antiporter activity
VA249_19780	COG0367	asparagine synthase
VA249_19800	COG3104	oligopeptide transport
VA249_19810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VA249_19830	COG0326	Molecular chaperone. Has ATPase activity
VA249_19840	COG3710	Transcriptional regulator
VA249_19880	COG0622	Phosphoesterase
VA249_19890	COG1090	epimerase
VA249_19900	COG0300	oxidoreductase activity
VA249_19910	COG3118	belongs to the thioredoxin family
VA249_19920	COG0330	HflC and HflK could
VA249_19930	COG1585	Membrane protein implicated in regulation of membrane protease activity
VA249_19990	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VA249_20000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VA249_20010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_20020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VA249_20030	COG2190	(PTS) system
VA249_20040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_20050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_20080	COG3951	Flagellar rod assembly protein muramidase FlgJ
VA249_20080	COG1705	Flagellar rod assembly protein muramidase FlgJ
VA249_20090	COG1706	bacterial-type flagellum-dependent cell motility
VA249_20100	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VA249_20120	COG4787	bacterial-type flagellum-dependent cell motility
VA249_20150	COG1558	bacterial-type flagellum-dependent cell motility
VA249_20160	COG1815	bacterial-type flagellum-dependent cell motility
VA249_20170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VA249_20180	COG0835	chemotaxis
VA249_20180	COG0784	Response regulator, receiver
VA249_20270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VA249_20280	COG2608	mercury ion transmembrane transporter activity
VA249_20280	COG2217	Heavy metal translocating P-type atpase
VA249_20340	COG2840	Smr protein MutS2
VA249_20350	COG1187	pseudouridine synthase activity
VA249_20360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VA249_20370	COG0737	Belongs to the 5'-nucleotidase family
VA249_20390	COG2912	Transglutaminase-like superfamily
VA249_20400	COG3094	Invasion gene expression up-regulator, SirB
VA249_20410	COG2890	protein-(glutamine-N5) methyltransferase activity
VA249_20420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VA249_20450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VA249_20460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VA249_20490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA249_20500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VA249_20510	COG1702	phosphate starvation-inducible protein PhoH
VA249_20530	COG4535	Mg2 and Co2 transporter CorC
VA249_20540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VA249_20550	COG2888	peptidyl-tyrosine sulfation
VA249_20560	COG0495	leucyl-tRNA aminoacylation
VA249_20570	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VA249_20580	COG1466	dna polymerase III delta subunit
VA249_20590	COG0799	negative regulation of ribosome biogenesis
VA249_20600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VA249_20610	COG0768	penicillin binding
VA249_20620	COG0772	Belongs to the SEDS family
VA249_20630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VA249_20640	COG1686	Belongs to the peptidase S11 family
VA249_20680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VA249_20690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VA249_20700	COG0366	Alpha amylase catalytic
VA249_20720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VA249_20730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VA249_20740	COG2011	ABC-type metal ion transport system permease component
VA249_20750	COG1464	Belongs to the NlpA lipoprotein family
VA249_20760	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VA249_20810	COG1611	Belongs to the LOG family
VA249_20820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA249_20840	COG2363	Small membrane protein
VA249_20860	COG0583	DNA-binding transcription factor activity
VA249_20880	COG0301	tRNA thio-modification
VA249_20880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA249_20900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VA249_20920	COG0142	geranyltranstransferase activity
VA249_20940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VA249_20950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VA249_21000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VA249_21000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VA249_21010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VA249_21020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VA249_21050	COG1073	alpha beta
VA249_21060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VA249_21070	COG2252	PERMEase
VA249_21080	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA249_21120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VA249_21120	COG0047	phosphoribosylformylglycinamidine synthase activity
VA249_21150	COG0590	tRNA wobble adenosine to inosine editing
VA249_21160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VA249_21210	COG0484	heat shock protein binding
VA249_21230	COG1301	dicarboxylic acid transport
VA249_21240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VA249_21260	COG0497	DNA recombination
VA249_21270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_21280	COG2914	Belongs to the UPF0125 (RnfH) family
VA249_21290	COG2867	negative regulation of translational initiation
VA249_21310	COG0582	viral genome integration into host DNA
VA249_21340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VA249_21420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VA249_21440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VA249_21610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VA249_21620	COG2873	o-acetylhomoserine
VA249_21640	COG0583	DNA-binding transcription factor activity
VA249_21670	COG1115	amino acid carrier protein
VA249_21680	COG1584	GPR1 FUN34 yaaH family protein
VA249_21700	COG0516	GMP reductase activity
VA249_21700	COG0517	IMP dehydrogenase activity
VA249_21750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_21760	COG2976	Protein conserved in bacteria
VA249_21770	COG0124	histidyl-tRNA synthetase
VA249_21830	COG2975	iron-sulfur cluster assembly
VA249_21840	COG0633	Ferredoxin
VA249_21870	COG0316	Belongs to the HesB IscA family
VA249_21880	COG0822	iron-sulfur transferase activity
VA249_21910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VA249_21920	COG0483	inositol monophosphate 1-phosphatase activity
VA249_21930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_21940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_21950	COG1862	Preprotein translocase
VA249_21960	COG0343	queuine tRNA-ribosyltransferase activity
VA249_21970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VA249_21990	COG0517	IMP dehydrogenase activity
VA249_22010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VA249_22020	COG0583	DNA-binding transcription factor activity
VA249_22030	COG0450	alkyl hydroperoxide reductase
VA249_22080	COG0704	Plays a role in the regulation of phosphate uptake
VA249_22090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VA249_22100	COG0581	inorganic phosphate transmembrane transporter activity
VA249_22110	COG0573	inorganic phosphate transmembrane transporter activity
VA249_22120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VA249_22130	COG0248	Ppx GppA phosphatase
VA249_22150	COG5002	protein histidine kinase activity
VA249_22160	COG0745	RESPONSE REGULATOR receiver
VA249_22170	COG2974	May be involved in recombination
VA249_22180	COG0826	peptidase U32
VA249_22190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VA249_22230	COG0542	response to heat
VA249_22240	COG1496	oxidoreductase activity
VA249_22250	COG0564	pseudouridine synthase activity
VA249_22260	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_22270	COG0741	lytic transglycosylase activity
VA249_22280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VA249_22290	COG0077	Prephenate dehydratase
VA249_22290	COG1605	Chorismate mutase
VA249_22300	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VA249_22330	COG0488	(ABC) transporter
VA249_22350	COG0739	heme binding
VA249_22360	COG1605	Chorismate mutase
VA249_22360	COG0287	Prephenate dehydrogenase
VA249_22370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA249_22390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VA249_22430	COG1966	Carbon starvation protein
VA249_22440	COG3275	phosphorelay sensor kinase activity
VA249_22450	COG3275	phosphorelay sensor kinase activity
VA249_22460	COG3279	Response regulator of the LytR AlgR family
VA249_22470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VA249_22480	COG1047	Peptidyl-prolyl cis-trans
VA249_22510	COG0196	riboflavin kinase activity
VA249_22520	COG0728	peptidoglycan biosynthetic process
VA249_22530	COG0268	Binds directly to 16S ribosomal RNA
VA249_22540	COG0640	Transcriptional regulator
VA249_22550	COG0583	DNA-binding transcription factor activity
VA249_22570	COG1283	sodium-dependent phosphate transmembrane transporter activity
VA249_22600	COG0730	response to heat
VA249_22610	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VA249_22630	COG3066	DNA modification
VA249_22650	COG0667	Aldo Keto reductase
VA249_22690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VA249_22700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VA249_22710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VA249_22720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA249_22730	COG4974	Belongs to the 'phage' integrase family
VA249_22740	COG0716	FMN binding
VA249_22770	COG0513	Belongs to the DEAD box helicase family
VA249_22780	COG3022	response to hydroperoxide
VA249_22840	COG1115	amino acid carrier protein
VA249_22870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VA249_22900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VA249_22910	COG0083	homoserine kinase activity
VA249_22940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VA249_22960	COG0745	RESPONSE REGULATOR receiver
VA249_22980	COG2198	Histidine kinase
VA249_22980	COG5002	protein histidine kinase activity
VA249_22980	COG0784	Response regulator, receiver
VA249_22990	COG1242	4 iron, 4 sulfur cluster binding
VA249_23000	COG0067	glutamate synthase
VA249_23000	COG0070	glutamate synthase
VA249_23000	COG0069	glutamate synthase activity
VA249_23020	COG0067	glutamate synthase
VA249_23020	COG0070	glutamate synthase
VA249_23020	COG0069	glutamate synthase activity
VA249_23030	COG0493	'glutamate synthase
VA249_23080	COG2860	membrane
VA249_23090	COG0583	DNA-binding transcription factor activity
VA249_23100	COG0730	response to heat
VA249_23110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VA249_23120	COG0505	Belongs to the CarA family
VA249_23140	COG0494	nUDIX hydrolase
VA249_23170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VA249_23180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VA249_23190	COG0849	cell division
VA249_23200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VA249_23230	COG0772	Belongs to the SEDS family
VA249_23250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VA249_23260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VA249_23270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VA249_23280	COG0768	penicillin binding
VA249_23290	COG3116	cell division
VA249_23320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VA249_23350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VA249_23360	COG2823	Periplasmic or secreted lipoprotein
VA249_23370	COG2969	positive regulation of protein catabolic process
VA249_23380	COG0625	glutathione transferase activity
VA249_23390	COG2857	Cytochrome c1
VA249_23400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VA249_23410	COG0723	plastoquinol--plastocyanin reductase activity
VA249_23440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VA249_23450	COG3105	Protein conserved in bacteria
VA249_23480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VA249_23500	COG3150	esterase
VA249_23520	COG3151	Protein conserved in bacteria
VA249_23530	COG0494	nUDIX hydrolase
VA249_23540	COG1538	Outer membrane efflux protein
VA249_23560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VA249_23580	COG3025	triphosphatase activity
VA249_23590	COG1392	Phosphate transport regulator
VA249_23600	COG0306	phosphate transporter
VA249_23610	COG4991	sh3 domain protein
VA249_23630	COG3267	Type II secretory pathway component ExeA
VA249_23630	COG3409	Peptidoglycan-binding domain 1 protein
VA249_23670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VA249_23680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VA249_23690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VA249_23700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VA249_23710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VA249_23720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VA249_23730	COG1610	YqeY-like protein
VA249_23740	COG0358	DNA primase activity
VA249_23780	COG1349	DNA-binding transcription factor activity
VA249_23790	COG0469	pyruvate kinase activity
VA249_23810	COG3706	GGDEF domain
VA249_23830	COG0028	Belongs to the TPP enzyme family
VA249_23840	COG1022	Amp-dependent synthetase and ligase
VA249_23850	COG0583	DNA-binding transcription factor activity
VA249_23890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VA249_23900	COG0473	3-isopropylmalate dehydrogenase activity
VA249_23940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VA249_23950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VA249_23960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA249_23970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VA249_23990	COG2967	ApaG domain
VA249_24010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VA249_24020	COG3610	response to peptide
VA249_24030	COG2966	Psort location CytoplasmicMembrane, score
VA249_24040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VA249_24060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VA249_24070	COG0142	geranyltranstransferase activity
VA249_24110	COG2358	TRAP transporter, solute receptor (TAXI family
VA249_24140	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VA249_24150	COG1178	ABC-type Fe3 transport system permease component
VA249_24160	COG4143	(ABC) transporter
VA249_24170	COG0163	prenyltransferase activity
VA249_24180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VA249_24190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VA249_24200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VA249_24210	COG2105	PFAM AIG2 family protein
VA249_24230	COG0729	surface antigen
VA249_24240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_24260	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VA249_24290	COG1136	(ABC) transporter
VA249_24330	COG0529	Catalyzes the synthesis of activated sulfate
VA249_24340	COG0471	metal ion transport
VA249_24340	COG3273	potassium ion transport
VA249_24370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VA249_24370	COG1648	precorrin-2 dehydrogenase activity
VA249_24380	COG0737	Belongs to the 5'-nucleotidase family
VA249_24400	COG0513	Belongs to the DEAD box helicase family
VA249_24410	COG2153	protein acetylation
VA249_24430	COG0545	Peptidyl-prolyl cis-trans isomerase
VA249_24450	COG0203	ribosomal protein L17
VA249_24460	COG0202	RNA polymerase activity
VA249_24480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VA249_24490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VA249_24500	COG0201	protein transport
VA249_24520	COG1841	ribosomal large subunit assembly
VA249_24550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VA249_24570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VA249_24580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VA249_24590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VA249_24600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VA249_24610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VA249_24660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VA249_24670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VA249_24690	COG0088	Forms part of the polypeptide exit tunnel
VA249_24700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VA249_24720	COG0254	rRNA binding
VA249_24730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VA249_24740	COG1609	Transcriptional regulator
VA249_24780	COG1575	Belongs to the MenA family. Type 1 subfamily
VA249_24790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VA249_24800	COG3074	FtsZ-dependent cytokinesis
VA249_24810	COG1494	fructose-1,6-bisphosphatase
VA249_24860	COG0149	triose-phosphate isomerase activity
VA249_24890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VA249_24900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VA249_25070	COG3335	DDE superfamily endonuclease
VA249_25100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VA249_25110	COG0673	inositol 2-dehydrogenase activity
VA249_25190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_25230	COG1560	Kdo2-lipid A biosynthetic process
VA249_25240	COG0859	PFAM glycosyl transferase family 9
VA249_25250	COG1519	Transferase
VA249_25270	COG0438	transferase activity, transferring glycosyl groups
VA249_25290	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_25300	COG1083	cytidylyl-transferase
VA249_25310	COG0673	inositol 2-dehydrogenase activity
VA249_25320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VA249_25340	COG2089	acid synthase
VA249_25350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VA249_25360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VA249_25370	COG1086	Polysaccharide biosynthesis protein
VA249_25380	COG3642	lipopolysaccharide core region biosynthetic process
VA249_25390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VA249_25400	COG0859	PFAM glycosyl transferase family 9
VA249_25410	COG0463	Glycosyl transferase, family 2
VA249_25420	COG0438	transferase activity, transferring glycosyl groups
VA249_25490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VA249_25510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VA249_25520	COG1309	transcriptional regulator
VA249_25530	COG1560	Kdo2-lipid A biosynthetic process
VA249_25540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VA249_25550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VA249_25560	COG1561	YicC-like family, N-terminal region
VA249_25600	COG4608	Belongs to the ABC transporter superfamily
VA249_25610	COG0444	Belongs to the ABC transporter superfamily
VA249_25620	COG0747	negative chemotaxis
VA249_25630	COG4239	(ABC) transporter, permease
VA249_25640	COG4174	ABC transporter (Permease)
VA249_25680	COG0811	peptide transport
VA249_25690	COG0848	biopolymer transport protein
VA249_25730	COG0194	GDP metabolic process
VA249_25740	COG1758	RNA polymerase activity
VA249_25750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VA249_25760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA249_25770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VA249_25780	COG4946	Tricorn protease homolog
VA249_25780	COG0823	Involved in the tonB-independent uptake of proteins
VA249_25780	COG1506	peptidase
VA249_25790	COG2233	PERMEase
VA249_25830	COG2801	Transposase and inactivated derivatives
VA249_25850	COG2183	response to ionizing radiation
VA249_25890	COG1040	competence protein
VA249_25910	COG0494	nUDIX hydrolase
VA249_25920	COG1218	3'(2'),5'-bisphosphate nucleotidase
VA249_25940	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VA249_25950	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VA249_25960	COG3156	type II secretion system protein K
VA249_25970	COG4795	General secretion pathway protein
VA249_25980	COG2165	general secretion pathway protein
VA249_25990	COG2165	general secretion pathway protein
VA249_26000	COG2165	general secretion pathway protein
VA249_26010	COG1459	type II secretion system
VA249_26020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA249_26040	COG3031	protein transport across the cell outer membrane
VA249_26050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VA249_26090	COG0456	acetyltransferase
VA249_26100	COG1490	D-aminoacyl-tRNA deacylase activity
VA249_26140	COG1217	gtp-binding protein TYPA
VA249_26150	COG0174	glutamine synthetase
VA249_26170	COG3852	Histidine kinase
VA249_26180	COG2204	response regulator
VA249_26210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VA249_26270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VA249_26280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA249_26280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA249_26310	COG0084	hydrolase, TatD family'
VA249_26320	COG0805	protein transport
VA249_26330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VA249_26360	COG3165	ubiquinone biosynthetic process from chorismate
VA249_26380	COG1322	Protein conserved in bacteria
VA249_26400	COG5001	Diguanylate cyclase
VA249_26400	COG3300	MHYT domain
VA249_26410	COG2081	HI0933 family
VA249_26430	COG1528	Iron-storage protein
VA249_26440	COG0589	response to stress
VA249_26480	COG1522	sequence-specific DNA binding
VA249_26500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VA249_26510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA249_26520	COG0800	Aldolase
VA249_26530	COG2610	gluconate transmembrane transporter activity
VA249_26540	COG3265	gluconokinase activity
VA249_26550	COG0129	dihydroxy-acid dehydratase activity
VA249_26570	COG2076	Multidrug Resistance protein
VA249_26580	COG0583	DNA-binding transcription factor activity
VA249_26590	COG1609	Transcriptional regulator
VA249_26670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_26680	COG0601	transmembrane transport
VA249_26690	COG0747	negative chemotaxis
VA249_26700	COG4172	Belongs to the ABC transporter superfamily
VA249_26740	COG1309	transcriptional regulator
VA249_26750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_26760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_26770	COG2960	long-chain fatty acid transporting porin activity
VA249_26780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VA249_26790	COG0583	DNA-binding transcription factor activity
VA249_26810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VA249_26860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VA249_26870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VA249_26900	COG0551	DNA topoisomerase type I activity
VA249_26920	COG0758	DNA mediated transformation
VA249_26940	COG0242	peptide deformylase activity
VA249_26960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VA249_26960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VA249_26970	COG0569	domain protein
VA249_26980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA249_27000	COG1272	protein, Hemolysin III
VA249_27010	COG4326	sporulation control protein
VA249_27030	COG3084	Protein conserved in bacteria
VA249_27050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VA249_27060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA249_27070	COG0204	Acyl-transferase
VA249_27090	COG0606	chelatase, subunit chli
VA249_27110	COG3978	acetolactate synthase activity
VA249_27120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VA249_27130	COG0129	dihydroxy-acid dehydratase activity
VA249_27150	COG0583	DNA-binding transcription factor activity
VA249_27160	COG2814	Major facilitator Superfamily
VA249_27180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VA249_27190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VA249_27200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VA249_27210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VA249_27230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VA249_27260	COG3312	ion transport
VA249_27270	COG1475	DNA binding
VA249_27280	COG1192	Involved in chromosome partitioning
VA249_27300	COG0445	tRNA wobble uridine modification
VA249_27310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VA249_27330	COG0706	membrane insertase activity
VA249_27340	COG0594	ribonuclease P activity
VA249_27360	COG1126	abc transporter atp-binding protein
VA249_27390	COG1609	Transcriptional regulator
VA249_27390	COG2207	Transcriptional regulator
VA249_27400	COG1070	Carbohydrate kinase
VA249_27420	COG1609	Transcriptional regulator
VA249_27450	COG0395	ABC-type sugar transport system, permease component
VA249_27460	COG2723	6-phospho-beta-galactosidase activity
VA249_27470	COG3842	ATPase activity
VA249_27480	COG1609	Transcriptional regulator
VA249_27500	COG0747	negative chemotaxis
VA249_27520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_27530	COG0444	Belongs to the ABC transporter superfamily
VA249_27540	COG4608	Belongs to the ABC transporter superfamily
VA249_27560	COG1609	Transcriptional regulator
VA249_27600	COG1472	Belongs to the glycosyl hydrolase 3 family
VA249_27610	COG0534	Mate efflux family protein
VA249_27620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VA249_27630	COG0564	pseudouridine synthase activity
VA249_27640	COG0561	phosphatase activity
VA249_27660	COG2199	diguanylate cyclase activity
VA249_27680	COG3152	Membrane
VA249_27700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VA249_27720	COG0583	DNA-binding transcription factor activity
VA249_27760	COG1522	sequence-specific DNA binding
VA249_27780	COG2076	Multidrug Resistance protein
VA249_27810	COG3047	cAMP biosynthetic process
VA249_27820	COG2358	TRAP transporter, solute receptor (TAXI family
VA249_27860	COG2814	Major facilitator Superfamily
VA249_28060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VA249_28070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VA249_28080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VA249_28090	COG1116	anion transmembrane transporter activity
VA249_28100	COG0351	phosphomethylpyrimidine kinase
VA249_28110	COG0312	modulator of DNA gyrase
VA249_28120	COG0312	modulator of DNA gyrase
VA249_28190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VA249_28210	COG0584	glycerophosphoryl diester phosphodiesterase
VA249_28220	COG0745	RESPONSE REGULATOR receiver
VA249_28230	COG0745	RESPONSE REGULATOR receiver
VA249_28270	COG0811	peptide transport
VA249_28280	COG0811	peptide transport
VA249_28290	COG0848	biopolymer transport protein
VA249_28340	COG1770	oligopeptidase
VA249_28350	COG2814	Major facilitator Superfamily
VA249_28360	COG0010	Belongs to the arginase family
VA249_28370	COG1166	arginine decarboxylase activity
VA249_28390	COG0189	ligase activity
VA249_28390	COG4067	protein conserved in archaea
VA249_28400	COG0189	ligase activity
VA249_28410	COG0583	DNA-binding transcription factor activity
VA249_28450	COG2723	6-phospho-beta-galactosidase activity
VA249_28470	COG2204	response regulator
VA249_28480	COG3706	GGDEF domain
VA249_28500	COG1114	Component of the transport system for branched-chain amino acids
VA249_28530	COG0579	oxidoreductase
VA249_28570	COG3033	Beta-eliminating lyase
VA249_28590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_28650	COG3706	GGDEF domain
VA249_28660	COG0415	Belongs to the DNA photolyase family
VA249_28670	COG3046	protein related to deoxyribodipyrimidine photolyase
VA249_28690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_28690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_28700	COG1765	OsmC-like protein
VA249_28730	COG1011	Hydrolase
VA249_28780	COG1511	domain protein
VA249_28780	COG3264	Mechanosensitive ion channel
VA249_28790	COG2866	Carboxypeptidase
VA249_28830	COG3104	oligopeptide transport
VA249_28840	COG1760	l-serine dehydratase
VA249_28890	COG1388	LysM domain
VA249_28890	COG0741	lytic transglycosylase activity
VA249_28930	COG1815	bacterial-type flagellum-dependent cell motility
VA249_28940	COG1558	bacterial-type flagellum-dependent cell motility
VA249_28950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VA249_28970	COG4787	bacterial-type flagellum-dependent cell motility
VA249_28990	COG4786	Flagellar basal body rod
VA249_29000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VA249_29010	COG1706	bacterial-type flagellum-dependent cell motility
VA249_29030	COG1256	bacterial-type flagellum assembly
VA249_29030	COG4786	Flagellar basal body rod
VA249_29100	COG0583	DNA-binding transcription factor activity
VA249_29150	COG1360	Flagellar Motor Protein
VA249_29160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VA249_29170	COG1191	sigma factor activity
VA249_29180	COG1580	Controls the rotational direction of flagella during chemotaxis
VA249_29210	COG1516	flagellar protein fliS
VA249_29220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VA249_29250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_29310	COG1987	bacterial-type flagellum assembly
VA249_29370	COG1677	Flagellar hook-basal body complex protein FliE
VA249_29470	COG0346	lactoylglutathione lyase activity
VA249_29520	COG0745	RESPONSE REGULATOR receiver
VA249_29540	COG3293	Transposase
VA249_29580	COG0156	8-amino-7-oxononanoate synthase activity
VA249_29590	COG1063	alcohol dehydrogenase
VA249_29600	COG0582	viral genome integration into host DNA
VA249_29830	COG1403	HNH endonuclease
VA249_29910	COG4220	transposase activity
VA249_30110	COG1063	alcohol dehydrogenase
VA249_30170	COG0668	transmembrane transport
VA249_30180	COG0668	transmembrane transport
VA249_30200	COG1304	FMN binding
VA249_30210	COG0583	DNA-binding transcription factor activity
VA249_30220	COG1505	serine-type exopeptidase activity
VA249_30230	COG1067	ATP-dependent peptidase activity
VA249_30260	COG1247	-acetyltransferase
VA249_30270	COG0437	4 iron, 4 sulfur cluster binding
VA249_30280	COG0348	domain, Protein
VA249_30290	COG0640	Transcriptional regulator
VA249_30320	COG1122	ATPase activity
VA249_30340	COG1566	PFAM secretion protein HlyD family protein
VA249_30400	COG0813	purine-nucleoside phosphorylase activity
VA249_30410	COG3272	Protein of unknown function (DUF1722)
VA249_30430	COG0415	Belongs to the DNA photolyase family
VA249_30440	COG1376	ErfK ybiS ycfS ynhG family protein
VA249_30440	COG1388	LysM domain
VA249_30460	COG0513	Belongs to the DEAD box helicase family
VA249_30480	COG0573	inorganic phosphate transmembrane transporter activity
VA249_30490	COG0581	inorganic phosphate transmembrane transporter activity
VA249_30500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VA249_30510	COG3706	GGDEF domain
VA249_30530	COG2304	oxidoreductase activity
VA249_30570	COG0714	Associated with various cellular activities
VA249_30580	COG0840	transmembrane signaling receptor activity
VA249_30600	COG2197	response regulator
VA249_30610	COG0110	maltose O-acetyltransferase activity
VA249_30620	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_30630	COG5001	Diguanylate cyclase
VA249_30630	COG2203	Gaf domain
VA249_30630	COG4251	negative regulation of phosphorylation
VA249_30630	COG3706	GGDEF domain
VA249_30680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VA249_30690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VA249_30700	COG2801	Transposase and inactivated derivatives
VA249_30710	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VA249_30730	COG1252	NADH dehydrogenase
VA249_30740	COG1301	dicarboxylic acid transport
VA249_30750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA249_30760	COG2706	6-phosphogluconolactonase activity
VA249_30770	COG1881	PFAM PEBP family protein
VA249_30790	COG0798	PFAM Bile acid sodium symporter
VA249_30840	COG0814	amino acid
VA249_30860	COG3314	Sporulation integral membrane protein YlbJ
VA249_30890	COG0739	heme binding
VA249_30920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_30930	COG0697	spore germination
VA249_30960	COG0179	Fumarylacetoacetate (FAA) hydrolase
VA249_30990	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VA249_31000	COG1280	lysine exporter protein (LysE YggA)
VA249_31010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA249_31040	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VA249_31050	COG1845	cytochrome c oxidase, subunit III
VA249_31090	COG1612	heme a metabolic process
VA249_31120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA249_31130	COG0840	transmembrane signaling receptor activity
VA249_31180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VA249_31220	COG2897	thiosulfate sulfurtransferase activity
VA249_31290	COG1914	H( )-stimulated, divalent metal cation uptake system
VA249_31340	COG4989	oxidoreductase activity
VA249_31370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VA249_31370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VA249_31390	COG1247	-acetyltransferase
VA249_31420	COG1566	PFAM secretion protein HlyD family protein
VA249_31440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VA249_31450	COG0076	glutamate decarboxylase activity
VA249_31520	COG4176	ABC-type proline glycine betaine transport system permease component
VA249_31530	COG0517	IMP dehydrogenase activity
VA249_31530	COG4175	Glycine betaine
VA249_31590	COG3300	MHYT domain
VA249_31590	COG5001	Diguanylate cyclase
VA249_31600	COG2205	protein histidine kinase activity
VA249_31600	COG0784	Response regulator, receiver
VA249_31680	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VA249_31700	COG0438	transferase activity, transferring glycosyl groups
VA249_31780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VA249_31790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VA249_31800	COG3206	protein involved in exopolysaccharide biosynthesis
VA249_31800	COG0489	protein tyrosine kinase activity
VA249_31830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VA249_31880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VA249_31890	COG5001	Diguanylate cyclase
VA249_31900	COG1869	D-ribose catabolic process
VA249_31910	COG0738	Major facilitator superfamily
VA249_31930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_31940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_31950	COG1609	Transcriptional regulator
VA249_31970	COG0789	Transcriptional regulator
VA249_32020	COG1289	transmembrane transporter activity
VA249_32030	COG0210	DNA helicase
VA249_32050	COG1879	ABC-type sugar transport system periplasmic component
VA249_32060	COG0784	Response regulator, receiver
VA249_32060	COG2198	Histidine kinase
VA249_32060	COG2205	protein histidine kinase activity
VA249_32090	COG3119	arylsulfatase activity
VA249_32100	COG3119	arylsulfatase activity
VA249_32110	COG3063	Type IV pilus biogenesis stability protein PilW
VA249_32120	COG0714	Associated with various cellular activities
VA249_32190	COG0583	DNA-binding transcription factor activity
VA249_32200	COG3111	PFAM Bacterial OB fold (BOF) protein
VA249_32240	COG0641	radical SAM
VA249_32290	COG3069	C4-dicarboxylate transmembrane transporter activity
VA249_32330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VA249_32340	COG0778	Nitroreductase
VA249_32350	COG0784	Response regulator, receiver
VA249_32350	COG0835	chemotaxis
VA249_32360	COG2165	general secretion pathway protein
VA249_32380	COG2962	Rard protein
VA249_32410	COG0671	phosphoesterase, PA-phosphatase related
VA249_32470	COG2067	long-chain fatty acid transport protein
VA249_32500	COG1902	pentaerythritol trinitrate reductase activity
VA249_32510	COG0346	lactoylglutathione lyase activity
VA249_32530	COG0420	3'-5' exonuclease activity
VA249_32540	COG0419	ATPase involved in DNA repair
VA249_32560	COG3469	chitinase activity
VA249_32600	COG3040	lipid binding
VA249_32740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VA249_32760	COG0509	glycine decarboxylation via glycine cleavage system
VA249_32770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VA249_32790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VA249_32850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_32850	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VA249_32850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_32860	COG1105	Belongs to the carbohydrate kinase PfkB family
VA249_32870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_32870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_32880	COG1609	Transcriptional regulator
VA249_32940	COG0668	transmembrane transport
VA249_32980	COG2239	Acts as a magnesium transporter
VA249_33000	COG0387	Pfam Sodium calcium exchanger
VA249_33020	COG0765	amino acid transport
VA249_33030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_33040	COG0765	amino acid transport
VA249_33050	COG1126	abc transporter atp-binding protein
VA249_33060	COG1979	alcohol dehydrogenase
VA249_33070	COG2207	Transcriptional regulator
VA249_33080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VA249_33100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_33130	COG0784	Response regulator, receiver
VA249_33130	COG3437	response regulator, receiver
VA249_33140	COG0546	phosphoglycolate phosphatase activity
VA249_33160	COG0513	Belongs to the DEAD box helicase family
VA249_33190	COG3038	cytochrome b561
VA249_33210	COG2116	formate transmembrane transporter activity
VA249_33220	COG0583	DNA-binding transcription factor activity
VA249_33240	COG3593	DNA synthesis involved in DNA repair
VA249_33250	COG0737	Belongs to the 5'-nucleotidase family
VA249_33260	COG0861	Integral membrane protein TerC family
VA249_33300	COG2267	carboxylic ester hydrolase activity
VA249_33310	COG2067	long-chain fatty acid transport protein
VA249_33340	COG2050	protein possibly involved in aromatic compounds catabolism
VA249_33360	COG4533	DNA binding
VA249_33420	COG0484	heat shock protein binding
VA249_33440	COG3300	MHYT domain
VA249_33440	COG5001	Diguanylate cyclase
VA249_33450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VA249_33470	COG4181	ATPase activity
VA249_33480	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VA249_33500	COG1984	allophanate hydrolase subunit 2
VA249_33510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VA249_33530	COG3447	MASE1 domain protein
VA249_33530	COG5001	Diguanylate cyclase
VA249_33530	COG5002	protein histidine kinase activity
VA249_33560	COG0583	DNA-binding transcription factor activity
VA249_33570	COG0045	succinate-CoA ligase (ADP-forming) activity
VA249_33570	COG1042	CoA-binding domain protein
VA249_33570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA249_33610	COG0023	Translation Initiation Factor
VA249_33640	COG3140	Belongs to the UPF0181 family
VA249_33690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VA249_33700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VA249_33750	COG5001	Diguanylate cyclase
VA249_33750	COG2203	Gaf domain
VA249_33750	COG4251	negative regulation of phosphorylation
VA249_33750	COG3706	GGDEF domain
VA249_33770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VA249_33780	COG4149	molybdate abc transporter
VA249_33790	COG0725	ABC transporter, periplasmic molybdate-binding protein
VA249_33800	COG0725	ABC transporter, periplasmic molybdate-binding protein
VA249_33840	COG3111	PFAM Bacterial OB fold (BOF) protein
VA249_33860	COG0189	ligase activity
VA249_33860	COG4067	protein conserved in archaea
VA249_33890	COG0534	Mate efflux family protein
VA249_33900	COG0602	queuosine metabolic process
VA249_33910	COG1328	CTP reductase activity
VA249_33990	COG1396	sequence-specific DNA binding
VA249_34000	COG3550	peptidyl-serine autophosphorylation
VA249_34050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VA249_34060	COG0732	type I restriction modification DNA specificity domain
VA249_34070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VA249_34110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VA249_34120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VA249_34170	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VA249_34250	COG1484	DNA-dependent DNA replication
VA249_34260	COG4584	PFAM Integrase catalytic
VA249_34370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VA249_34380	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA249_34410	COG0402	S-adenosylhomocysteine deaminase activity
VA249_34430	COG0628	permease
VA249_34450	COG1566	PFAM secretion protein HlyD family protein
VA249_34480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VA249_34490	COG3118	belongs to the thioredoxin family
VA249_34570	COG2116	formate transmembrane transporter activity
VA249_34590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VA249_34600	COG3706	GGDEF domain
VA249_34640	COG0277	FAD linked oxidase domain protein
VA249_34650	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VA249_34680	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VA249_34700	COG1288	antiporter activity
VA249_34720	COG2814	Major facilitator Superfamily
VA249_34740	COG1196	nuclear chromosome segregation
VA249_34780	COG1132	(ABC) transporter
VA249_34830	COG0318	PFAM AMP-dependent synthetase and ligase
VA249_34850	COG0628	permease
VA249_34930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VA249_34930	COG2146	nitrite reductase [NAD(P)H] activity
VA249_34940	COG1116	anion transmembrane transporter activity
VA249_34950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VA249_34960	COG1116	anion transmembrane transporter activity
VA249_34960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VA249_34980	COG3707	response regulator
VA249_35010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VA249_35010	COG1648	precorrin-2 dehydrogenase activity
VA249_35020	COG0243	molybdopterin cofactor binding
VA249_35040	COG0814	amino acid
VA249_35080	COG1785	Belongs to the alkaline phosphatase family
VA249_35090	COG5002	protein histidine kinase activity
VA249_35100	COG0745	RESPONSE REGULATOR receiver
VA249_35130	COG2801	Transposase and inactivated derivatives
VA249_35150	COG0443	Heat shock 70 kDa protein
VA249_35180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VA249_35260	COG4160	amino acid transport
VA249_35270	COG4215	(ABC) transporter
VA249_35280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_35290	COG1126	abc transporter atp-binding protein
VA249_35320	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA249_35320	COG1902	pentaerythritol trinitrate reductase activity
VA249_35330	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_35360	COG1024	Enoyl-CoA hydratase
VA249_35370	COG1024	Enoyl-CoA hydratase
VA249_35380	COG1960	acyl-CoA dehydrogenase activity
VA249_35400	COG0183	Belongs to the thiolase family
VA249_35410	COG0183	Belongs to the thiolase family
VA249_35430	COG1960	acyl-CoA dehydrogenase activity
VA249_35440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VA249_35450	COG1024	Enoyl-CoA hydratase
VA249_35490	COG3278	Belongs to the heme-copper respiratory oxidase family
VA249_35520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VA249_35530	COG0513	Belongs to the DEAD box helicase family
VA249_35540	COG3335	DDE superfamily endonuclease
VA249_35560	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VA249_35580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VA249_35770	COG1396	sequence-specific DNA binding
VA249_35770	COG1917	Cupin 2, conserved barrel domain protein
VA249_35790	COG1566	PFAM secretion protein HlyD family protein
VA249_35840	COG2801	Transposase and inactivated derivatives
VA249_35850	COG3293	Transposase
VA249_35870	COG3706	GGDEF domain
VA249_35880	COG2252	PERMEase
VA249_35890	COG1119	ATPase activity
VA249_35930	COG0513	Belongs to the DEAD box helicase family
VA249_35940	COG0523	cobalamin synthesis protein
VA249_36000	COG3416	Protein conserved in bacteria
VA249_36020	COG3293	Transposase
VA249_36040	COG3530	Putative quorum-sensing-regulated virulence factor
VA249_36090	COG3186	Phenylalanine-4-hydroxylase
VA249_36100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VA249_36110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA249_36160	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VA249_36170	COG1454	alcohol dehydrogenase
VA249_36180	COG2133	pyrroloquinoline quinone binding
VA249_36200	COG0783	Belongs to the Dps family
VA249_36210	COG0840	transmembrane signaling receptor activity
VA249_36230	COG1136	(ABC) transporter
VA249_36230	COG0577	efflux transmembrane transporter activity
VA249_36240	COG0577	efflux transmembrane transporter activity
VA249_36240	COG1136	(ABC) transporter
VA249_36280	COG1278	Cold shock
VA249_36340	COG0545	Peptidyl-prolyl cis-trans isomerase
VA249_36390	COG2197	response regulator
VA249_36400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA249_36420	COG0840	transmembrane signaling receptor activity
VA249_36460	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA249_36490	COG2197	response regulator
VA249_36500	COG3850	Histidine kinase
VA249_36540	COG3005	denitrification pathway
VA249_36580	COG0183	Belongs to the thiolase family
VA249_36600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_36610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_36650	COG1522	sequence-specific DNA binding
VA249_36690	COG2827	Endonuclease containing a URI domain
VA249_36750	COG0673	inositol 2-dehydrogenase activity
VA249_36790	COG0583	DNA-binding transcription factor activity
VA249_36840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA249_36880	COG1566	PFAM secretion protein HlyD family protein
VA249_36890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VA249_36900	COG2239	Acts as a magnesium transporter
VA249_36910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VA249_36920	COG0402	S-adenosylhomocysteine deaminase activity
VA249_36950	COG1418	mRNA catabolic process
VA249_36970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VA249_37000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA249_37030	COG4221	oxidoreductase activity
VA249_37050	COG0745	RESPONSE REGULATOR receiver
VA249_37060	COG2205	protein histidine kinase activity
VA249_37080	COG2194	sulfuric ester hydrolase activity
VA249_37100	COG2814	Major facilitator Superfamily
VA249_37140	COG0583	DNA-binding transcription factor activity
VA249_37150	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_37180	COG0583	DNA-binding transcription factor activity
VA249_37230	COG0366	Alpha amylase catalytic
VA249_37400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA249_37410	COG0784	Response regulator, receiver
VA249_37410	COG0835	chemotaxis
VA249_37430	COG0748	coenzyme F420 binding
VA249_37440	COG3721	Heme iron utilization protein
VA249_37460	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VA249_37470	COG0811	peptide transport
VA249_37480	COG0848	biopolymer transport protein
VA249_37500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA249_37510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VA249_37610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VA249_37630	COG0633	Ferredoxin
VA249_37630	COG3217	Mosc domain protein beta barrel domain protein
VA249_37630	COG0633	Ferredoxin
VA249_37630	COG3217	Mosc domain protein beta barrel domain protein
VA249_37640	COG0401	homolog of Blt101
VA249_37660	COG2354	Protein conserved in bacteria
VA249_37680	COG2999	glutathione oxidoreductase activity
VA249_37690	COG0604	alcohol dehydrogenase
VA249_37810	COG3833	ABC-type maltose transport systems, permease component
VA249_37820	COG1175	transmembrane transport
VA249_37840	COG3842	ATPase activity
VA249_37860	COG1309	transcriptional regulator
VA249_37870	COG2130	NADP-dependent
VA249_37890	COG0753	catalase activity
VA249_37900	COG2084	Dehydrogenase
VA249_37920	COG0583	DNA-binding transcription factor activity
VA249_37930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_37940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_37960	COG2207	Transcriptional regulator
VA249_37970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_37970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_37970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_37980	COG1482	cell wall glycoprotein biosynthetic process
VA249_37990	COG2211	Major facilitator Superfamily
VA249_38000	COG1486	melibiose metabolic process
VA249_38010	COG2169	Transcriptional regulator
VA249_38030	COG0813	purine-nucleoside phosphorylase activity
VA249_38040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VA249_38060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_38070	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_38080	COG2233	PERMEase
VA249_38090	COG0402	S-adenosylhomocysteine deaminase activity
VA249_38120	COG3383	formate dehydrogenase (NAD+) activity
VA249_38150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_38200	COG3321	synthase
VA249_38200	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_38200	COG0604	alcohol dehydrogenase
VA249_38240	COG1247	-acetyltransferase
VA249_38250	COG1505	serine-type exopeptidase activity
VA249_38270	COG0589	response to stress
VA249_38320	COG4667	esterase of the alpha-beta hydrolase superfamily
VA249_38330	COG1741	Belongs to the pirin family
VA249_38340	COG1278	Cold shock
VA249_38370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_38370	COG0678	peroxiredoxin activity
VA249_38390	COG1686	Belongs to the peptidase S11 family
VA249_38410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_38420	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_38430	COG0583	DNA-binding transcription factor activity
VA249_38440	COG0625	glutathione transferase activity
VA249_38460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VA249_38470	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_38510	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_38530	COG0583	DNA-binding transcription factor activity
VA249_38540	COG2207	Transcriptional regulator
VA249_38540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VA249_38550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA249_38600	COG0513	Belongs to the DEAD box helicase family
VA249_38610	COG4977	sequence-specific DNA binding
VA249_38640	COG0589	response to stress
VA249_38650	COG3122	Protein conserved in bacteria
VA249_38680	COG0583	DNA-binding transcription factor activity
VA249_38690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VA249_38730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VA249_38740	COG0574	Belongs to the PEP-utilizing enzyme family
VA249_38740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VA249_38760	COG3302	dmso reductase anchor subunit
VA249_38770	COG0437	4 iron, 4 sulfur cluster binding
VA249_38780	COG0243	molybdopterin cofactor binding
VA249_38790	COG3381	protein complex oligomerization
VA249_38820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VA249_38850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_38880	COG0786	glutamate:sodium symporter activity
VA249_38910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_38950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_39000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA249_39010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA249_39070	COG3710	Transcriptional regulator
VA249_39090	COG3710	Transcriptional regulator
VA249_39120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_39160	COG1342	Belongs to the UPF0251 family
VA249_39180	COG4176	ABC-type proline glycine betaine transport system permease component
VA249_39190	COG4175	Glycine betaine
VA249_39190	COG3448	diguanylate cyclase activity
VA249_39200	COG3015	lipoprotein NlpE involved in copper resistance
VA249_39210	COG0583	DNA-binding transcription factor activity
VA249_39290	COG1335	isochorismatase
VA249_39330	COG0346	lactoylglutathione lyase activity
VA249_39360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_39380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA249_39430	COG4628	conserved protein (DUF2132)
VA249_39440	COG0488	(ABC) transporter
VA249_39510	COG0628	permease
VA249_39520	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VA249_39540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA249_39560	COG4628	conserved protein (DUF2132)
VA249_39570	COG0583	DNA-binding transcription factor activity
VA249_39610	COG1234	tRNA 3'-trailer cleavage
VA249_39640	COG1686	Belongs to the peptidase S11 family
VA249_39670	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VA249_39690	COG3397	chitin binding
VA249_39720	COG0840	transmembrane signaling receptor activity
VA249_39730	COG4667	esterase of the alpha-beta hydrolase superfamily
VA249_39790	COG2095	MarC family integral membrane protein
VA249_39800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VA249_39870	COG1301	dicarboxylic acid transport
VA249_39880	COG3339	Conserved Protein
VA249_39890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VA249_39900	COG0700	Nucleoside recognition
VA249_39910	COG3366	ferrous iron transmembrane transporter activity
VA249_39920	COG0366	Alpha amylase catalytic
VA249_39930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VA249_39940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VA249_39950	COG1640	4-alpha-glucanotransferase
VA249_39960	COG0058	SHG alpha-glucan phosphorylase activity
VA249_40020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_40020	COG1263	PTS System
VA249_40030	COG1162	GTPase activity
VA249_40040	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VA249_40070	COG0531	amino acid
VA249_40080	COG1982	Orn Lys Arg decarboxylase major
VA249_40120	COG0366	Alpha amylase catalytic
VA249_40150	COG4580	involved in the transport of maltose and maltodextrins
VA249_40180	COG3706	GGDEF domain
VA249_40220	COG4771	TonB-dependent receptor
VA249_40230	COG0583	DNA-binding transcription factor activity
VA249_40240	COG4607	ABC-type enterochelin transport system periplasmic component
VA249_40250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA249_40260	COG4605	iron ion homeostasis
VA249_40270	COG4604	ABC transporter, ATP-binding protein
VA249_40350	COG1566	PFAM secretion protein HlyD family protein
VA249_40390	COG0826	peptidase U32
VA249_40420	COG1136	(ABC) transporter
VA249_40430	COG0577	efflux transmembrane transporter activity
VA249_40480	COG3634	alkyl hydroperoxide reductase activity
VA249_40490	COG1278	Cold shock
VA249_40500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VA249_40510	COG1522	sequence-specific DNA binding
VA249_40520	COG0006	proline dipeptidase activity
VA249_40570	COG0596	Alpha beta hydrolase
VA249_40590	COG0513	Belongs to the DEAD box helicase family
VA249_40600	COG1312	Catalyzes the dehydration of D-mannonate
VA249_40610	COG0246	Mannitol dehydrogenase
VA249_40620	COG1904	glucuronate isomerase
VA249_40630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_40640	COG0800	Aldolase
VA249_40670	COG3250	beta-galactosidase activity
VA249_40690	COG2186	Transcriptional regulator
VA249_40730	COG1132	(ABC) transporter
VA249_40800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_40850	COG0259	pyridoxamine-phosphate oxidase activity
VA249_40930	COG1132	(ABC) transporter
VA249_40980	COG1444	tRNA N-acetyltransferase activity
VA249_41050	COG0772	Belongs to the SEDS family
VA249_41070	COG1566	PFAM secretion protein HlyD family protein
VA249_41080	COG0583	DNA-binding transcription factor activity
VA249_41100	COG1136	(ABC) transporter
VA249_41140	COG3275	phosphorelay sensor kinase activity
VA249_41150	COG3279	Response regulator of the LytR AlgR family
VA249_41170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VA249_41210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VA249_41220	COG1999	signal sequence binding
VA249_41300	COG0786	glutamate:sodium symporter activity
VA249_41320	COG1131	(ABC) transporter
VA249_41330	COG0786	glutamate:sodium symporter activity
VA249_41340	COG3119	arylsulfatase activity
VA249_41370	COG0641	radical SAM
VA249_41380	COG3119	arylsulfatase activity
VA249_41410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_41420	COG0800	Aldolase
VA249_41490	COG1566	PFAM secretion protein HlyD family protein
VA249_41590	COG3119	arylsulfatase activity
VA249_41600	COG1349	DNA-binding transcription factor activity
VA249_41620	COG2222	sugar isomerase
VA249_41630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_41640	COG3715	PTS system
VA249_41650	COG3716	PTS system mannose fructose sorbose family IID component
VA249_41660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_41690	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_41780	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VA249_41790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VA249_41810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VA249_41870	COG3123	guanosine phosphorylase activity
VA249_41890	COG3842	ATPase activity
VA249_41920	COG3842	ATPase activity
VA249_41940	COG1175	transmembrane transport
VA249_41950	COG0395	ABC-type sugar transport system, permease component
VA249_41980	COG2017	converts alpha-aldose to the beta-anomer
VA249_41990	COG1472	Belongs to the glycosyl hydrolase 3 family
VA249_42050	COG0210	DNA helicase
VA249_42480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VA249_42710	COG0210	DNA helicase
VA249_42910	COG0330	HflC and HflK could
VA249_42970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VA249_43150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VA249_43200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VA249_43210	COG1061	Type III restriction enzyme res subunit
VA249_43220	COG1002	Type II restriction enzyme, methylase subunits
VA249_43440	COG0561	phosphatase activity
VA249_43470	COG2160	L-arabinose isomerase activity
VA249_43480	COG0235	Class ii aldolase
VA249_43490	COG1069	ribulokinase activity
VA249_43510	COG1879	ABC-type sugar transport system periplasmic component
VA249_43520	COG1129	ABC transporter
VA249_43530	COG1172	Belongs to the binding-protein-dependent transport system permease family
VA249_43600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA249_43610	COG0840	transmembrane signaling receptor activity
VA249_43630	COG3335	DDE superfamily endonuclease
VA249_43640	COG4580	involved in the transport of maltose and maltodextrins
VA249_43660	COG1874	Beta-galactosidase
VA249_43680	COG3833	ABC-type maltose transport systems, permease component
VA249_43690	COG1175	transmembrane transport
VA249_43700	COG2182	Extracellular solute-binding protein
VA249_43720	COG1609	Transcriptional regulator
VA249_43740	COG0667	Aldo Keto reductase
VA249_43750	COG0667	Aldo Keto reductase
VA249_43810	COG3039	Transposase
VA249_44000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_44060	COG0640	Transcriptional regulator
VA249_44090	COG0786	glutamate:sodium symporter activity
VA249_44580	COG1192	Involved in chromosome partitioning
VA249_44870	COG1404	Belongs to the peptidase S8 family
VA249_45060	COG1793	dna ligase
VA249_45350	COG0714	Associated with various cellular activities
VA249_45430	COG4974	Belongs to the 'phage' integrase family
VA249_46120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII