locus-tag	class	description
D1115_00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1115_00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1115_00035	COG1126	abc transporter atp-binding protein
D1115_00060	COG0592	DNA-directed DNA polymerase activity
D1115_00070	COG0187	DNA topoisomerase II activity
D1115_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
D1115_00085	COG3977	Valine--pyruvate aminotransferase
D1115_00100	COG2119	membrane
D1115_00125	COG0604	alcohol dehydrogenase
D1115_00130	COG0183	Belongs to the thiolase family
D1115_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1115_00220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1115_00225	COG2104	thiamine diphosphate biosynthetic process
D1115_00240	COG0006	proline dipeptidase activity
D1115_00240	COG0006	proline dipeptidase activity
D1115_00250	COG2814	Major facilitator Superfamily
D1115_00270	COG3220	belongs to the UPF0276 family
D1115_00280	COG0210	DNA helicase
D1115_00290	COG0405	Gamma-glutamyltransferase
D1115_00295	COG1280	lysine exporter protein (LysE YggA)
D1115_00305	COG2962	Rard protein
D1115_00310	COG0514	ATP-dependent DNA helicase (RecQ)
D1115_00325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D1115_00330	COG0248	Ppx GppA phosphatase
D1115_00340	COG3118	belongs to the thioredoxin family
D1115_00345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1115_00355	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1115_00360	COG0633	Ferredoxin
D1115_00420	COG1587	Uroporphyrinogen-III synthase
D1115_00435	COG1965	Belongs to the frataxin family
D1115_00445	COG0019	diaminopimelate decarboxylase activity
D1115_00465	COG1011	Hydrolase
D1115_00485	COG0561	phosphatase activity
D1115_00490	COG2267	carboxylic ester hydrolase activity
D1115_00495	COG1280	lysine exporter protein (LysE YggA)
D1115_00500	COG0640	Transcriptional regulator
D1115_00505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1115_00560	COG0742	ribosomal rna small subunit methyltransferase
D1115_00570	COG2884	Cell division ATP-binding protein ftsE
D1115_00575	COG2177	Part of the ABC transporter FtsEX involved in
D1115_00590	COG0705	Rhomboid family
D1115_00595	COG1580	Controls the rotational direction of flagella during chemotaxis
D1115_00600	COG3161	chorismate lyase activity
D1115_00610	COG2937	Belongs to the GPAT DAPAT family
D1115_00630	COG0534	Mate efflux family protein
D1115_00635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1115_00715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1115_00725	COG1072	(Pantothenic acid kinase))
D1115_00765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1115_00770	COG0250	Participates in transcription elongation, termination and antitermination
D1115_00780	COG0081	regulation of translation
D1115_00785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1115_00800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1115_00805	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D1115_00810	COG2816	NAD+ diphosphatase activity
D1115_00820	COG1573	uracil-dna glycosylase
D1115_00830	COG3068	Protein conserved in bacteria
D1115_00835	COG1253	flavin adenine dinucleotide binding
D1115_00850	COG0151	Belongs to the GarS family
D1115_00855	COG0138	bifunctional purine biosynthesis protein purh
D1115_00870	COG3710	Transcriptional regulator
D1115_00880	COG0531	amino acid
D1115_00885	COG1982	Orn Lys Arg decarboxylase major
D1115_00960	COG5001	Diguanylate cyclase
D1115_00960	COG3300	MHYT domain
D1115_00965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D1115_00970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1115_00980	COG0439	Biotin carboxylase
D1115_00985	COG0511	ligase activity, forming carbon-carbon bonds
D1115_00990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1115_00995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1115_01010	COG2814	Major facilitator Superfamily
D1115_01015	COG2205	protein histidine kinase activity
D1115_01015	COG2198	Histidine kinase
D1115_01015	COG0784	Response regulator, receiver
D1115_01025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_01035	COG2095	MarC family integral membrane protein
D1115_01045	COG4232	protein-disulfide reductase activity
D1115_01050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1115_01055	COG1027	Aspartate ammonia-lyase
D1115_01060	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1115_01065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1115_01070	COG2205	protein histidine kinase activity
D1115_01075	COG0745	RESPONSE REGULATOR receiver
D1115_01080	COG3678	ATP-independent chaperone mediated protein folding
D1115_01095	COG0534	Mate efflux family protein
D1115_01105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1115_01125	COG1509	lysine 2,3-aminomutase activity
D1115_01145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1115_01150	COG1053	succinate dehydrogenase
D1115_01175	COG4942	peptidase
D1115_01180	COG1045	serine acetyltransferase
D1115_01195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1115_01200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1115_01215	COG0471	metal ion transport
D1115_01230	COG1162	GTPase activity
D1115_01235	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1115_01315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1115_01320	COG0802	atpase or kinase
D1115_01345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1115_01350	COG0330	HflC and HflK could
D1115_01355	COG0330	HflC and HflK could
D1115_01360	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D1115_01365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1115_01370	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D1115_01375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1115_01375	COG1017	nitric oxide dioxygenase activity
D1115_01385	COG0557	exoribonuclease II activity
D1115_01390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1115_01395	COG0546	phosphoglycolate phosphatase activity
D1115_01405	COG0512	Glutamine amidotransferase of anthranilate synthase
D1115_01410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1115_01430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1115_01435	COG3954	Phosphoribulokinase
D1115_01440	COG3089	Belongs to the UPF0270 family
D1115_01445	COG0429	hydrolase of the alpha beta-hydrolase fold
D1115_01455	COG0488	(ABC) transporter
D1115_01460	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_01475	COG1047	Peptidyl-prolyl cis-trans
D1115_01485	COG1446	asparaginase
D1115_01500	COG0545	Peptidyl-prolyl cis-trans isomerase
D1115_01505	COG2964	Protein conserved in bacteria
D1115_01510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1115_01515	COG2923	Belongs to the DsrF TusC family
D1115_01535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1115_01545	COG2906	2 iron, 2 sulfur cluster binding
D1115_01555	COG0281	malic enzyme
D1115_01565	COG0626	cystathionine gamma-synthase activity
D1115_01570	COG0460	homoserine dehydrogenase
D1115_01570	COG0527	aspartate kinase activity
D1115_01575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1115_01585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1115_01595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1115_01610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1115_01610	COG0165	Argininosuccinate lyase
D1115_01625	COG0678	peroxiredoxin activity
D1115_01625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_01635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1115_01680	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D1115_01685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1115_01695	COG2965	DNA replication, synthesis of RNA primer
D1115_01705	COG0359	binds to the 23S rRNA
D1115_01715	COG0305	Participates in initiation and elongation during chromosome replication
D1115_01720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1115_01730	COG0432	Pfam Uncharacterised protein family UPF0047
D1115_01745	COG0735	belongs to the Fur family
D1115_01750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1115_01770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1115_01835	COG3335	DDE superfamily endonuclease
D1115_01845	COG3335	DDE superfamily endonuclease
D1115_01860	COG0527	aspartate kinase activity
D1115_01870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1115_01880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1115_01890	COG2197	response regulator
D1115_01895	COG0629	single-stranded DNA binding
D1115_01900	COG2199	diguanylate cyclase activity
D1115_01900	COG2200	EAL domain
D1115_01920	COG1450	Type ii and iii secretion system protein
D1115_01925	COG3409	Peptidoglycan-binding domain 1 protein
D1115_01925	COG3267	Type II secretory pathway component ExeA
D1115_02000	COG1077	Cell shape determining protein MreB Mrl
D1115_02005	COG1792	Involved in formation and maintenance of cell shape
D1115_02010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D1115_02015	COG0424	maF-like protein
D1115_02020	COG1530	ribonuclease E activity
D1115_02030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1115_02035	COG0312	modulator of DNA gyrase
D1115_02040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D1115_02045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1115_02050	COG0564	pseudouridine synthase activity
D1115_02055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1115_02060	COG3028	Belongs to the UPF0307 family
D1115_02065	COG0312	modulator of DNA gyrase
D1115_02070	COG2239	Acts as a magnesium transporter
D1115_02075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_02085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_02090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1115_02100	COG1137	ATPase activity
D1115_02105	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D1115_02115	COG0517	IMP dehydrogenase activity
D1115_02115	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1115_02125	COG1127	ABC transporter
D1115_02130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1115_02135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1115_02140	COG2854	intermembrane phospholipid transfer
D1115_02150	COG5007	Belongs to the BolA IbaG family
D1115_02160	COG0204	Acyl-transferase
D1115_02165	COG0251	oxidation-reduction process
D1115_02205	COG0456	acetyltransferase
D1115_02215	COG0525	valine-tRNA ligase activity
D1115_02225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1115_02230	COG0795	lipopolysaccharide-transporting ATPase activity
D1115_02250	COG0582	viral genome integration into host DNA
D1115_02285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D1115_02290	COG0732	type I restriction modification DNA specificity domain
D1115_02305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1115_02325	COG3153	acetyltransferase
D1115_02325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1115_02445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D1115_02450	COG1194	a g-specific adenine glycosylase
D1115_02470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1115_02475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1115_02490	COG0762	integral membrane protein
D1115_02495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1115_02500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1115_02515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1115_02520	COG1678	Uncharacterized ACR, COG1678
D1115_02525	COG0189	ligase activity
D1115_02530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1115_02535	COG2356	endonuclease I
D1115_02555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1115_02570	COG0191	fructose-bisphosphate aldolase activity
D1115_02580	COG0668	transmembrane transport
D1115_02595	COG0583	DNA-binding transcription factor activity
D1115_02605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1115_02615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1115_02625	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D1115_02630	COG3079	Belongs to the UPF0149 family
D1115_02635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1115_02640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1115_02660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1115_02670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1115_02675	COG1595	DNA-templated transcription, initiation
D1115_02690	COG3086	response to oxidative stress
D1115_02700	COG0681	Belongs to the peptidase S26 family
D1115_02710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1115_02715	COG1381	Involved in DNA repair and RecF pathway recombination
D1115_02720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1115_02745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1115_02750	COG3956	TIGRFAM MazG family protein
D1115_02760	COG0148	phosphopyruvate hydratase activity
D1115_02770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1115_02775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1115_02800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1115_02810	COG1546	Belongs to the CinA family
D1115_02815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1115_02830	COG0527	aspartate kinase activity
D1115_02930	COG5016	pyruvate
D1115_02930	COG0511	ligase activity, forming carbon-carbon bonds
D1115_02935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D1115_02945	COG1238	metal cluster binding
D1115_02950	COG0612	Peptidase, M16
D1115_02970	COG4536	flavin adenine dinucleotide binding
D1115_02975	COG4137	Cytochrome C assembly protein
D1115_02980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1115_03005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1115_03010	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D1115_03015	COG0237	dephospho-CoA kinase activity
D1115_03025	COG1459	type II secretion system
D1115_03030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1115_03050	COG2186	Transcriptional regulator
D1115_03055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1115_03060	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1115_03065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1115_03080	COG0288	reversible hydration of carbon dioxide
D1115_03085	COG0659	secondary active sulfate transmembrane transporter activity
D1115_03090	COG1131	(ABC) transporter
D1115_03095	COG0842	Transport permease protein
D1115_03110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1115_03120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1115_03125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1115_03130	COG1489	DNA binding
D1115_03135	COG1643	Atp-dependent helicase
D1115_03140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1115_03145	COG1752	Esterase of the alpha-beta hydrolase superfamily
D1115_03150	COG1049	propionate catabolic process, 2-methylcitrate cycle
D1115_03155	COG1929	Belongs to the glycerate kinase type-1 family
D1115_03160	COG2610	gluconate transmembrane transporter activity
D1115_03165	COG3835	regulator
D1115_03180	COG0004	ammonium transporteR
D1115_03185	COG1840	ABC-type Fe3 transport system, periplasmic component
D1115_03195	COG3842	ATPase activity
D1115_03200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1115_03215	COG2971	BadF BadG BcrA BcrD
D1115_03225	COG4608	Belongs to the ABC transporter superfamily
D1115_03230	COG0444	Belongs to the ABC transporter superfamily
D1115_03245	COG0747	negative chemotaxis
D1115_03270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1115_03275	COG0316	Belongs to the HesB IscA family
D1115_03290	COG0739	heme binding
D1115_03295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1115_03310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D1115_03315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1115_03320	COG1534	Rna-binding protein
D1115_03325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1115_03330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1115_03340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1115_03355	COG0779	Required for maturation of 30S ribosomal subunits
D1115_03360	COG0195	Participates in both transcription termination and antitermination
D1115_03380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1115_03385	COG1185	polyribonucleotide nucleotidyltransferase activity
D1115_03395	COG1846	Transcriptional regulator
D1115_03400	COG0534	Mate efflux family protein
D1115_03425	COG3153	acetyltransferase
D1115_03450	COG0084	hydrolase, TatD family'
D1115_03455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_03465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D1115_03475	COG0813	purine-nucleoside phosphorylase activity
D1115_03495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1115_03500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1115_03505	COG1022	Amp-dependent synthetase and ligase
D1115_03515	COG0583	DNA-binding transcription factor activity
D1115_03520	COG1609	Transcriptional regulator
D1115_03525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1115_03540	COG2017	converts alpha-aldose to the beta-anomer
D1115_03545	COG1609	Transcriptional regulator
D1115_03565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1115_03570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1115_03580	COG2171	N-acyltransferase activity
D1115_03595	COG3141	response to X-ray
D1115_03610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D1115_03615	COG1074	ATP-dependent DNA helicase activity
D1115_03620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1115_03700	COG0784	Response regulator, receiver
D1115_03700	COG2205	protein histidine kinase activity
D1115_03705	COG2205	protein histidine kinase activity
D1115_03705	COG0784	Response regulator, receiver
D1115_03715	COG2204	response regulator
D1115_03720	COG5002	protein histidine kinase activity
D1115_03720	COG5001	Diguanylate cyclase
D1115_03795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1115_03800	COG2166	iron-sulfur cluster assembly
D1115_03805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1115_03810	COG0693	protein deglycase activity
D1115_03815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1115_03820	COG3248	Nucleoside-binding outer membrane protein
D1115_03840	COG1595	DNA-templated transcription, initiation
D1115_03865	COG2813	Specifically methylates the guanine in position
D1115_03870	COG0271	Belongs to the BolA IbaG family
D1115_03895	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1115_03905	COG1477	protein flavinylation
D1115_03920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1115_03925	COG0514	ATP-dependent DNA helicase (RecQ)
D1115_03930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1115_03940	COG0733	neurotransmitter:sodium symporter activity
D1115_03965	COG1720	tRNA m6t6A37 methyltransferase activity
D1115_03970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D1115_04000	COG3098	single-species biofilm formation
D1115_04005	COG0564	pseudouridine synthase activity
D1115_04020	COG0024	Methionine aminopeptidase
D1115_04030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1115_04045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1115_04050	COG0575	Belongs to the CDS family
D1115_04060	COG0750	zinc metalloprotease
D1115_04070	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D1115_04075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1115_04100	COG0587	DNA-directed DNA polymerase activity
D1115_04120	COG0347	Belongs to the P(II) protein family
D1115_04135	COG1388	LysM domain
D1115_04135	COG0741	lytic transglycosylase activity
D1115_04145	COG2226	methyltransferase
D1115_04155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1115_04170	COG1960	acyl-CoA dehydrogenase activity
D1115_04175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1115_04180	COG0121	glutamine amidotransferase
D1115_04185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1115_04190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1115_04195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1115_04200	COG2233	PERMEase
D1115_04220	COG1393	Belongs to the ArsC family
D1115_04225	COG4783	chaperone-mediated protein folding
D1115_04240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1115_04245	COG2716	regulation of RNA biosynthetic process
D1115_04250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1115_04275	COG1393	Belongs to the ArsC family
D1115_04300	COG2837	iron assimilation
D1115_04315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_04320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_04325	COG1334	flagellar protein FlaG
D1115_04330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D1115_04340	COG1516	flagellar protein fliS
D1115_04355	COG4191	Histidine kinase
D1115_04360	COG2204	response regulator
D1115_04365	COG1677	Flagellar hook-basal body complex protein FliE
D1115_04375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D1115_04420	COG1987	bacterial-type flagellum assembly
D1115_04425	COG1684	flagellar biosynthetic protein fliR
D1115_04445	COG0455	bacterial-type flagellum organization
D1115_04460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D1115_04465	COG2198	Histidine kinase
D1115_04465	COG0643	Histidine kinase
D1115_04470	COG2201	protein-glutamate methylesterase activity
D1115_04475	COG1192	Involved in chromosome partitioning
D1115_04485	COG0835	chemotaxis
D1115_04495	COG4133	protoheme IX ABC transporter activity
D1115_04500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1115_04520	COG1138	Cytochrome C-type biogenesis protein
D1115_04525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1115_04535	COG4235	cytochrome complex assembly
D1115_04535	COG3088	subunit of a heme lyase
D1115_04540	COG2853	Lipoprotein
D1115_04545	COG2067	long-chain fatty acid transport protein
D1115_04550	COG2067	long-chain fatty acid transport protein
D1115_04575	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1115_04575	COG1024	Enoyl-CoA hydratase
D1115_04590	COG2062	phosphohistidine phosphatase, SixA
D1115_04600	COG2890	protein-(glutamine-N5) methyltransferase activity
D1115_04605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1115_04610	COG2860	membrane
D1115_04615	COG3101	peptidyl-lysine hydroxylation
D1115_04635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1115_04645	COG0583	DNA-binding transcription factor activity
D1115_04650	COG4771	TonB-dependent receptor
D1115_04670	COG1263	PTS System
D1115_04670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_04675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_04680	COG1621	beta-fructofuranosidase activity
D1115_04685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1115_04690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1115_04710	COG0285	dihydrofolate synthase activity
D1115_04720	COG1286	toxin biosynthetic process
D1115_04725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1115_04730	COG0583	DNA-binding transcription factor activity
D1115_04735	COG0745	RESPONSE REGULATOR receiver
D1115_04740	COG2832	Protein of unknown function (DUF454)
D1115_04750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1115_04755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1115_04760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1115_04765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1115_04775	COG2983	Belongs to the UPF0260 family
D1115_04780	COG2261	transglycosylase associated protein
D1115_04785	COG2985	domain, Protein
D1115_04790	COG0076	glutamate decarboxylase activity
D1115_04795	COG0668	transmembrane transport
D1115_04810	COG1522	sequence-specific DNA binding
D1115_04815	COG1946	Acyl-CoA thioesterase
D1115_04820	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D1115_04835	COG3706	GGDEF domain
D1115_04845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1115_04850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D1115_04860	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1115_04865	COG0517	IMP dehydrogenase activity
D1115_04865	COG0516	GMP reductase activity
D1115_04895	COG0537	adenosine 5'-monophosphoramidase activity
D1115_04915	COG0510	thiamine kinase activity
D1115_04925	COG1252	NADH dehydrogenase
D1115_04940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1115_04950	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1115_04955	COG1136	(ABC) transporter
D1115_04960	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1115_04975	COG1132	(ABC) transporter
D1115_04995	COG2719	SpoVR family
D1115_05005	COG2766	serine protein kinase
D1115_05020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1115_05030	COG1882	Formate acetyltransferase
D1115_05055	COG4215	(ABC) transporter
D1115_05065	COG0708	Exodeoxyribonuclease III
D1115_05070	COG3923	Primosomal replication protein n
D1115_05075	COG0730	response to heat
D1115_05080	COG1199	ATP-dependent helicase activity
D1115_05090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D1115_05095	COG1187	pseudouridine synthase activity
D1115_05105	COG1278	Cold shock
D1115_05115	COG0542	response to heat
D1115_05120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1115_05125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D1115_05150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1115_05160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1115_05165	COG0297	glycogen (starch) synthase activity
D1115_05185	COG3070	regulator of competence-specific genes
D1115_05195	COG3381	protein complex oligomerization
D1115_05200	COG0745	RESPONSE REGULATOR receiver
D1115_05205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1115_05215	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D1115_05220	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D1115_05225	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1115_05250	COG0500	methyltransferase
D1115_05255	COG4106	trans-aconitate 2-methyltransferase activity
D1115_05260	COG1801	Protein of unknown function DUF72
D1115_05265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1115_05270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1115_05275	COG0632	four-way junction helicase activity
D1115_05285	COG1271	oxidase subunit
D1115_05290	COG1294	oxidase, subunit
D1115_05295	COG4890	Cyd operon protein YbgT
D1115_05305	COG0824	Thioesterase
D1115_05310	COG0811	peptide transport
D1115_05325	COG0823	Involved in the tonB-independent uptake of proteins
D1115_05330	COG2885	chlorophyll binding
D1115_05335	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D1115_05340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1115_05355	COG0784	Response regulator, receiver
D1115_05355	COG5002	protein histidine kinase activity
D1115_05370	COG4584	PFAM Integrase catalytic
D1115_05375	COG1484	DNA-dependent DNA replication
D1115_05380	COG2020	methyltransferase activity
D1115_05410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_05435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_05455	COG2176	DNA-directed DNA polymerase activity
D1115_05460	COG0517	IMP dehydrogenase activity
D1115_05465	COG2186	Transcriptional regulator
D1115_05470	COG2186	Transcriptional regulator
D1115_05475	COG0534	Mate efflux family protein
D1115_05480	COG2731	YhcH YjgK YiaL family protein
D1115_05495	COG1917	Cupin 2, conserved barrel domain protein
D1115_05500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_05505	COG0800	Aldolase
D1115_05520	COG2084	Dehydrogenase
D1115_05535	COG0583	DNA-binding transcription factor activity
D1115_05545	COG0686	Belongs to the AlaDH PNT family
D1115_05560	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D1115_05565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1115_05575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1115_05580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1115_05645	COG2268	Band 7 protein
D1115_05655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1115_05665	COG0482	sulfurtransferase activity
D1115_05675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_05685	COG1757	Na H antiporter
D1115_05695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1115_05705	COG0131	Imidazoleglycerol-phosphate dehydratase
D1115_05705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1115_05710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1115_05715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1115_05720	COG0107	imidazoleglycerol-phosphate synthase activity
D1115_05725	COG0140	phosphoribosyl-ATP diphosphatase activity
D1115_05725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1115_05735	COG3012	SEC-C Motif Domain Protein
D1115_05745	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1115_05750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1115_05755	COG0215	cysteine-tRNA ligase activity
D1115_05760	COG1435	thymidine kinase activity
D1115_05765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1115_05790	COG2116	formate transmembrane transporter activity
D1115_05795	COG0390	transport system, permease component
D1115_05800	COG4459	periplasmic nitrate reductase
D1115_05805	COG3005	denitrification pathway
D1115_05810	COG0243	molybdopterin cofactor binding
D1115_05825	COG1227	inorganic diphosphatase activity
D1115_05835	COG4172	Belongs to the ABC transporter superfamily
D1115_05845	COG4171	peptide transport system, permease
D1115_05850	COG4168	peptide transport system, permease
D1115_05860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D1115_05865	COG1842	Phage shock protein A
D1115_05885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_05895	COG2818	Glycosylase
D1115_05900	COG0626	cystathionine gamma-synthase activity
D1115_05910	COG0733	neurotransmitter:sodium symporter activity
D1115_05920	COG0564	pseudouridine synthase activity
D1115_05930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1115_05935	COG1151	hydroxylamine reductase activity
D1115_05940	COG3604	Transcriptional regulator
D1115_05950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1115_05955	COG4136	ATPase activity
D1115_05960	COG4135	transport system, permease component
D1115_05965	COG4134	Bacterial extracellular solute-binding protein
D1115_05970	COG0398	Pfam SNARE associated Golgi protein
D1115_05980	COG0493	'glutamate synthase
D1115_06005	COG3313	Fe-S protein
D1115_06025	COG2205	protein histidine kinase activity
D1115_06030	COG0745	RESPONSE REGULATOR receiver
D1115_06045	COG1187	pseudouridine synthase activity
D1115_06050	COG2814	Major facilitator Superfamily
D1115_06060	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_06070	COG1609	Transcriptional regulator
D1115_06080	COG0534	Mate efflux family protein
D1115_06085	COG4181	ATPase activity
D1115_06110	COG1960	acyl-CoA dehydrogenase activity
D1115_06115	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1115_06125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_06135	COG1737	Transcriptional regulator
D1115_06140	COG0076	glutamate decarboxylase activity
D1115_06150	COG2431	L-lysine efflux transmembrane transporter activity
D1115_06160	COG3070	regulator of competence-specific genes
D1115_06165	COG2801	Transposase and inactivated derivatives
D1115_06170	COG2963	transposase activity
D1115_06185	COG4191	Histidine kinase
D1115_06185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_06195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1115_06215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D1115_06220	COG4988	ABC transporter
D1115_06225	COG0492	ferredoxin-NADP+ reductase activity
D1115_06245	COG3706	GGDEF domain
D1115_06250	COG0471	metal ion transport
D1115_06275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1115_06310	COG0277	FAD linked oxidase domain protein
D1115_06310	COG0247	lactate metabolic process
D1115_06325	COG2986	histidine ammonia-lyase
D1115_06330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1115_06360	COG1960	acyl-CoA dehydrogenase activity
D1115_06375	COG3706	GGDEF domain
D1115_06405	COG4245	von Willebrand factor, type A
D1115_06415	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D1115_06605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1115_06615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1115_06630	COG0393	Putative heavy-metal-binding
D1115_06645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1115_06645	COG0072	phenylalanine-tRNA ligase activity
D1115_06675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1115_06680	COG1643	Atp-dependent helicase
D1115_06690	COG0534	Mate efflux family protein
D1115_06695	COG2113	Glycine betaine
D1115_06700	COG4176	ABC-type proline glycine betaine transport system permease component
D1115_06720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_06725	COG0456	acetyltransferase
D1115_06730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1115_06735	COG0662	Cupin 2, conserved barrel domain protein
D1115_06745	COG0583	DNA-binding transcription factor activity
D1115_06750	COG0702	epimerase
D1115_06780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1115_06785	COG0363	glucosamine-6-phosphate deaminase activity
D1115_06790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1115_06880	COG3284	Transcriptional regulator
D1115_06885	COG1012	belongs to the aldehyde dehydrogenase family
D1115_06900	COG0730	response to heat
D1115_06905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1115_06910	COG2186	Transcriptional regulator
D1115_06915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1115_06920	COG0372	Belongs to the citrate synthase family
D1115_06930	COG2828	Protein conserved in bacteria
D1115_06950	COG0561	phosphatase activity
D1115_06955	COG0602	queuosine metabolic process
D1115_07005	COG0840	transmembrane signaling receptor activity
D1115_07010	COG1254	Belongs to the acylphosphatase family
D1115_07015	COG2920	part of a sulfur-relay system
D1115_07020	COG0670	Belongs to the BI1 family
D1115_07025	COG1126	abc transporter atp-binding protein
D1115_07030	COG0765	amino acid transport
D1115_07035	COG4597	amino acid ABC transporter
D1115_07040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_07055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1115_07095	COG1132	(ABC) transporter
D1115_07105	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D1115_07120	COG0308	aminopeptidase N
D1115_07135	COG0167	dihydroorotate dehydrogenase activity
D1115_07155	COG0488	(ABC) transporter
D1115_07175	COG1067	ATP-dependent peptidase activity
D1115_07180	COG3120	sequence-specific DNA binding
D1115_07230	COG3278	Belongs to the heme-copper respiratory oxidase family
D1115_07250	COG2217	Heavy metal translocating P-type atpase
D1115_07265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1115_07270	COG0589	response to stress
D1115_07295	COG3842	ATPase activity
D1115_07300	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1115_07305	COG1177	transmembrane transport
D1115_07310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1115_07315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1115_07320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1115_07340	COG0437	4 iron, 4 sulfur cluster binding
D1115_07345	COG0243	molybdopterin cofactor binding
D1115_07345	COG3383	formate dehydrogenase (NAD+) activity
D1115_07375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1115_07400	COG4191	Histidine kinase
D1115_07405	COG2204	response regulator
D1115_07420	COG3842	ATPase activity
D1115_07430	COG0303	'Molybdopterin
D1115_07475	COG2201	protein-glutamate methylesterase activity
D1115_07490	COG0307	riboflavin synthase, alpha
D1115_07495	COG0534	Mate efflux family protein
D1115_07515	COG3064	Membrane
D1115_07540	COG3247	response to pH
D1115_07550	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D1115_07630	COG0110	maltose O-acetyltransferase activity
D1115_07635	COG0438	transferase activity, transferring glycosyl groups
D1115_07655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1115_07680	COG0625	glutathione transferase activity
D1115_07690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1115_07740	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1115_07770	COG0583	DNA-binding transcription factor activity
D1115_07775	COG2814	Major facilitator Superfamily
D1115_07785	COG0583	DNA-binding transcription factor activity
D1115_07850	COG0813	purine-nucleoside phosphorylase activity
D1115_07855	COG1177	transmembrane transport
D1115_07860	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1115_07865	COG3842	ATPase activity
D1115_07870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1115_07875	COG2423	ornithine cyclodeaminase activity
D1115_07885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1115_07890	COG3938	Belongs to the proline racemase family
D1115_07915	COG2205	protein histidine kinase activity
D1115_07915	COG0784	Response regulator, receiver
D1115_07930	COG1451	nucleotide metabolic process
D1115_07940	COG0583	DNA-binding transcription factor activity
D1115_07975	COG1115	amino acid carrier protein
D1115_07980	COG1280	lysine exporter protein (LysE YggA)
D1115_07985	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D1115_07990	COG1560	Kdo2-lipid A biosynthetic process
D1115_07995	COG1280	lysine exporter protein (LysE YggA)
D1115_08000	COG0531	amino acid
D1115_08010	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D1115_08015	COG3063	Type IV pilus biogenesis stability protein PilW
D1115_08025	COG4139	cobalamin transport
D1115_08050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1115_08065	COG0702	epimerase
D1115_08075	COG2188	Transcriptional regulator
D1115_08080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_08080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_08080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_08085	COG0383	alpha-mannosidase activity
D1115_08090	COG1482	cell wall glycoprotein biosynthetic process
D1115_08120	COG0295	cytidine deaminase activity
D1115_08140	COG0776	regulation of translation
D1115_08150	COG2199	diguanylate cyclase activity
D1115_08160	COG0443	Heat shock 70 kDa protein
D1115_08165	COG0443	Heat shock 70 kDa protein
D1115_08180	COG1132	(ABC) transporter
D1115_08185	COG1132	(ABC) transporter
D1115_08200	COG3437	response regulator, receiver
D1115_08205	COG0814	amino acid
D1115_08220	COG0861	Integral membrane protein TerC family
D1115_08230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1115_08235	COG1328	CTP reductase activity
D1115_08250	COG5001	Diguanylate cyclase
D1115_08260	COG4191	Histidine kinase
D1115_08260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_08285	COG2944	sequence-specific DNA binding
D1115_08290	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D1115_08295	COG0346	lactoylglutathione lyase activity
D1115_08645	COG3340	Belongs to the peptidase S51 family
D1115_08870	COG0546	phosphoglycolate phosphatase activity
D1115_08890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D1115_08925	COG2026	Addiction module toxin, RelE StbE family
D1115_08945	COG0494	nUDIX hydrolase
D1115_09140	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_09290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1115_09305	COG3106	COG3106 Predicted ATPase
D1115_09320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1115_09330	COG0814	amino acid
D1115_09335	COG1760	l-serine dehydratase
D1115_09345	COG0720	synthase
D1115_09350	COG0017	Asparaginyl-tRNA synthetase
D1115_09385	COG0840	transmembrane signaling receptor activity
D1115_09390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_09420	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1115_09435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1115_09440	COG3108	Peptidase M15
D1115_09450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1115_09470	COG2801	Transposase and inactivated derivatives
D1115_09475	COG2801	Transposase and inactivated derivatives
D1115_09480	COG2963	transposase activity
D1115_09490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1115_09500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1115_09505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1115_09525	COG0287	Prephenate dehydrogenase
D1115_09530	COG0019	diaminopimelate decarboxylase activity
D1115_09575	COG0322	excinuclease ABC activity
D1115_09580	COG2197	response regulator
D1115_09585	COG0417	DNA replication proofreading
D1115_09600	COG3099	Belongs to the UPF0263 family
D1115_09605	COG1187	pseudouridine synthase activity
D1115_09610	COG0009	L-threonylcarbamoyladenylate synthase
D1115_09615	COG0613	PHP domain protein
D1115_09625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1115_09630	COG0512	Glutamine amidotransferase of anthranilate synthase
D1115_09640	COG0134	indole-3-glycerol-phosphate synthase activity
D1115_09640	COG0135	phosphoribosylanthranilate isomerase activity
D1115_09650	COG0159	tryptophan synthase activity
D1115_09655	COG1301	dicarboxylic acid transport
D1115_09665	COG1607	acyl-coa hydrolase
D1115_09670	COG2350	Protein conserved in bacteria
D1115_09680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1115_09685	COG0583	DNA-binding transcription factor activity
D1115_09705	COG1032	radical SAM domain protein
D1115_09710	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1115_09725	COG2964	Protein conserved in bacteria
D1115_09730	COG0840	transmembrane signaling receptor activity
D1115_09740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1115_09745	COG0463	Glycosyl transferase, family 2
D1115_09755	COG3850	Histidine kinase
D1115_09755	COG5002	protein histidine kinase activity
D1115_09825	COG3118	belongs to the thioredoxin family
D1115_09830	COG4232	protein-disulfide reductase activity
D1115_09840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1115_09845	COG2211	Major facilitator Superfamily
D1115_09865	COG3250	beta-galactosidase activity
D1115_09870	COG1609	Transcriptional regulator
D1115_09880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1115_09880	COG3008	intermembrane lipid transfer
D1115_09885	COG3009	Protein conserved in bacteria
D1115_09900	COG4166	transmembrane transport
D1115_09925	COG0539	negative regulation of cytoplasmic translation
D1115_09930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1115_09935	COG0616	signal peptide processing
D1115_09940	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_09960	COG0835	chemotaxis
D1115_09960	COG0784	Response regulator, receiver
D1115_09965	COG1940	carbohydrate kinase activity
D1115_09995	COG1263	PTS System
D1115_09995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_10000	COG0084	hydrolase, TatD family'
D1115_10015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1115_10045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1115_10060	COG1399	metal-binding, possibly nucleic acid-binding protein
D1115_10070	COG0564	pseudouridine synthase activity
D1115_10075	COG1530	ribonuclease E activity
D1115_10080	COG0659	secondary active sulfate transmembrane transporter activity
D1115_10085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1115_10090	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D1115_10095	COG2982	Protein involved in outer membrane biogenesis
D1115_10100	COG0572	uridine kinase
D1115_10120	COG2186	Transcriptional regulator
D1115_10130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1115_10135	COG0653	protein targeting
D1115_10140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1115_10155	COG1122	ATPase activity
D1115_10160	COG4120	Belongs to the binding-protein-dependent transport system permease family
D1115_10180	COG0857	belongs to the CobB CobQ family
D1115_10180	COG0280	phosphate acetyltransferase
D1115_10185	COG3174	membrane
D1115_10190	COG0435	Glutathione S-transferase
D1115_10200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1115_10210	COG0444	Belongs to the ABC transporter superfamily
D1115_10215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1115_10220	COG0601	transmembrane transport
D1115_10230	COG0314	molybdopterin synthase activity
D1115_10235	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D1115_10245	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1115_10250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1115_10255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1115_10260	COG2198	Histidine kinase
D1115_10265	COG2204	response regulator
D1115_10270	COG0556	nucleotide-excision repair
D1115_10280	COG1882	Formate acetyltransferase
D1115_10285	COG4657	Part of a membrane complex involved in electron transport
D1115_10295	COG4656	Part of a membrane complex involved in electron transport
D1115_10300	COG4658	electron transport chain
D1115_10310	COG4660	Part of a membrane complex involved in electron transport
D1115_10315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1115_10320	COG0346	lactoylglutathione lyase activity
D1115_10330	COG2885	chlorophyll binding
D1115_10340	COG2056	Na+-H+ antiporter family
D1115_10350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1115_10375	COG2095	MarC family integral membrane protein
D1115_10380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1115_10390	COG1757	Na H antiporter
D1115_10430	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1115_10435	COG4948	Mandelate Racemase Muconate Lactonizing
D1115_10445	COG2721	sulfolactate sulfo-lyase activity
D1115_10470	COG0778	Nitroreductase
D1115_10475	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1115_10475	COG1902	pentaerythritol trinitrate reductase activity
D1115_10480	COG0616	signal peptide processing
D1115_10485	COG0252	asparaginase activity
D1115_10490	COG3139	Protein of unknown function (DUF1315)
D1115_10500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_10505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1115_10515	COG2226	methyltransferase
D1115_10535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_10540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_10595	COG2855	membrane
D1115_10610	COG1441	menaquinone biosynthetic process
D1115_10615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1115_10620	COG0596	Alpha beta hydrolase
D1115_10630	COG1169	isochorismate synthase
D1115_10635	COG0436	Aminotransferase
D1115_10660	COG1555	photosystem II stabilization
D1115_10665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1115_10670	COG0776	regulation of translation
D1115_10675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1115_10680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1115_10715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1115_10720	COG0569	domain protein
D1115_10725	COG0513	Belongs to the DEAD box helicase family
D1115_10745	COG0840	transmembrane signaling receptor activity
D1115_10750	COG0582	viral genome integration into host DNA
D1115_10865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_10875	COG2951	lytic endotransglycosylase activity
D1115_10890	COG2894	cell division
D1115_10895	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D1115_10905	COG0318	PFAM AMP-dependent synthetase and ligase
D1115_10910	COG0596	Alpha beta hydrolase
D1115_10925	COG1214	PFAM Peptidase M22, glycoprotease
D1115_10930	COG1199	ATP-dependent helicase activity
D1115_10935	COG0788	formyltetrahydrofolate deformylase activity
D1115_10940	COG3102	Protein conserved in bacteria
D1115_10965	COG1918	ferrous iron import across plasma membrane
D1115_10975	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D1115_10985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1115_11000	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1115_11005	COG0567	Dehydrogenase, E1 component
D1115_11010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1115_11015	COG1053	succinate dehydrogenase
D1115_11020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D1115_11025	COG2009	succinate dehydrogenase
D1115_11035	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1115_11045	COG0033	Phosphoglucomutase
D1115_11050	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D1115_11065	COG0716	FMN binding
D1115_11075	COG0735	belongs to the Fur family
D1115_11085	COG1263	PTS System
D1115_11085	COG2190	(PTS) system
D1115_11085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_11095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1115_11105	COG4651	solute:proton antiporter activity
D1115_11105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1115_11110	COG0367	asparagine synthase
D1115_11120	COG3104	oligopeptide transport
D1115_11125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1115_11140	COG3710	Transcriptional regulator
D1115_11160	COG0622	Phosphoesterase
D1115_11170	COG1090	epimerase
D1115_11175	COG0300	oxidoreductase activity
D1115_11185	COG3118	belongs to the thioredoxin family
D1115_11190	COG0330	HflC and HflK could
D1115_11195	COG1585	Membrane protein implicated in regulation of membrane protease activity
D1115_11225	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D1115_11230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1115_11240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_11245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1115_11250	COG2190	(PTS) system
D1115_11255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_11260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_11275	COG1705	Flagellar rod assembly protein muramidase FlgJ
D1115_11275	COG3951	Flagellar rod assembly protein muramidase FlgJ
D1115_11280	COG1706	bacterial-type flagellum-dependent cell motility
D1115_11285	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D1115_11290	COG4786	Flagellar basal body rod
D1115_11295	COG4787	bacterial-type flagellum-dependent cell motility
D1115_11300	COG1749	Flagellar hook protein flgE
D1115_11305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D1115_11310	COG1558	bacterial-type flagellum-dependent cell motility
D1115_11315	COG1815	bacterial-type flagellum-dependent cell motility
D1115_11320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D1115_11325	COG0835	chemotaxis
D1115_11325	COG0784	Response regulator, receiver
D1115_11375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1115_11420	COG2840	Smr protein MutS2
D1115_11425	COG1187	pseudouridine synthase activity
D1115_11430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1115_11435	COG0737	Belongs to the 5'-nucleotidase family
D1115_11445	COG2912	Transglutaminase-like superfamily
D1115_11450	COG3094	Invasion gene expression up-regulator, SirB
D1115_11455	COG2890	protein-(glutamine-N5) methyltransferase activity
D1115_11475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1115_11480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1115_11600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1115_11610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1115_11615	COG1702	phosphate starvation-inducible protein PhoH
D1115_11625	COG4535	Mg2 and Co2 transporter CorC
D1115_11630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1115_11635	COG2888	peptidyl-tyrosine sulfation
D1115_11640	COG0495	leucyl-tRNA aminoacylation
D1115_11645	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D1115_11655	COG0799	negative regulation of ribosome biogenesis
D1115_11660	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1115_11665	COG0768	penicillin binding
D1115_11670	COG0772	Belongs to the SEDS family
D1115_11675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1115_11680	COG1686	Belongs to the peptidase S11 family
D1115_11700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1115_11705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1115_11710	COG0366	Alpha amylase catalytic
D1115_11715	COG1263	PTS System
D1115_11715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_11725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1115_11730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1115_11735	COG2011	ABC-type metal ion transport system permease component
D1115_11740	COG1464	Belongs to the NlpA lipoprotein family
D1115_11745	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D1115_11765	COG3706	GGDEF domain
D1115_11765	COG0745	RESPONSE REGULATOR receiver
D1115_11770	COG1611	Belongs to the LOG family
D1115_11775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1115_11785	COG2363	Small membrane protein
D1115_11800	COG0301	tRNA thio-modification
D1115_11800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1115_11810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D1115_11820	COG0142	geranyltranstransferase activity
D1115_11830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D1115_11835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1115_11860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1115_11860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1115_11865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1115_11870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1115_11890	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1115_11900	COG2252	PERMEase
D1115_11905	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1115_11925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1115_11925	COG0047	phosphoribosylformylglycinamidine synthase activity
D1115_11945	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D1115_11975	COG0484	heat shock protein binding
D1115_11985	COG1301	dicarboxylic acid transport
D1115_11990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1115_12000	COG0497	DNA recombination
D1115_12005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1115_12010	COG2914	Belongs to the UPF0125 (RnfH) family
D1115_12015	COG2867	negative regulation of translational initiation
D1115_12030	COG0582	viral genome integration into host DNA
D1115_12065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1115_12210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1115_12215	COG2873	o-acetylhomoserine
D1115_12220	COG0583	DNA-binding transcription factor activity
D1115_12235	COG1115	amino acid carrier protein
D1115_12240	COG1584	GPR1 FUN34 yaaH family protein
D1115_12250	COG0517	IMP dehydrogenase activity
D1115_12250	COG0516	GMP reductase activity
D1115_12275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1115_12280	COG2976	Protein conserved in bacteria
D1115_12315	COG2975	iron-sulfur cluster assembly
D1115_12320	COG0633	Ferredoxin
D1115_12335	COG0316	Belongs to the HesB IscA family
D1115_12340	COG0822	iron-sulfur transferase activity
D1115_12355	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1115_12360	COG0483	inositol monophosphate 1-phosphatase activity
D1115_12365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_12370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_12375	COG1862	Preprotein translocase
D1115_12380	COG0343	queuine tRNA-ribosyltransferase activity
D1115_12385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1115_12395	COG0517	IMP dehydrogenase activity
D1115_12405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1115_12410	COG0583	DNA-binding transcription factor activity
D1115_12415	COG0450	alkyl hydroperoxide reductase
D1115_12445	COG0704	Plays a role in the regulation of phosphate uptake
D1115_12450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1115_12455	COG0581	inorganic phosphate transmembrane transporter activity
D1115_12470	COG0248	Ppx GppA phosphatase
D1115_12480	COG5002	protein histidine kinase activity
D1115_12485	COG0745	RESPONSE REGULATOR receiver
D1115_12495	COG2974	May be involved in recombination
D1115_12505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1115_12565	COG0542	response to heat
D1115_12575	COG0564	pseudouridine synthase activity
D1115_12580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1115_12590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1115_12595	COG1605	Chorismate mutase
D1115_12595	COG0077	Prephenate dehydratase
D1115_12600	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D1115_12615	COG0488	(ABC) transporter
D1115_12630	COG1605	Chorismate mutase
D1115_12630	COG0287	Prephenate dehydrogenase
D1115_12635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1115_12640	COG1472	Belongs to the glycosyl hydrolase 3 family
D1115_12645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1115_12665	COG1966	Carbon starvation protein
D1115_12670	COG3275	phosphorelay sensor kinase activity
D1115_12675	COG3279	Response regulator of the LytR AlgR family
D1115_12680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1115_12685	COG1047	Peptidyl-prolyl cis-trans
D1115_12700	COG0196	riboflavin kinase activity
D1115_12705	COG0728	peptidoglycan biosynthetic process
D1115_12710	COG0268	Binds directly to 16S ribosomal RNA
D1115_12715	COG0640	Transcriptional regulator
D1115_12720	COG0583	DNA-binding transcription factor activity
D1115_12725	COG1283	sodium-dependent phosphate transmembrane transporter activity
D1115_12740	COG0730	response to heat
D1115_12760	COG3066	DNA modification
D1115_12770	COG0667	Aldo Keto reductase
D1115_12800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1115_12805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1115_12815	COG0716	FMN binding
D1115_12830	COG0513	Belongs to the DEAD box helicase family
D1115_12835	COG3022	response to hydroperoxide
D1115_12840	COG1115	amino acid carrier protein
D1115_12855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1115_12875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1115_12880	COG0083	homoserine kinase activity
D1115_12895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1115_12920	COG0784	Response regulator, receiver
D1115_12920	COG5002	protein histidine kinase activity
D1115_12920	COG2198	Histidine kinase
D1115_12925	COG1242	4 iron, 4 sulfur cluster binding
D1115_12930	COG0067	glutamate synthase
D1115_12930	COG0069	glutamate synthase activity
D1115_12930	COG0070	glutamate synthase
D1115_12940	COG0067	glutamate synthase
D1115_12940	COG0070	glutamate synthase
D1115_12940	COG0069	glutamate synthase activity
D1115_12945	COG0493	'glutamate synthase
D1115_12970	COG2860	membrane
D1115_12975	COG0583	DNA-binding transcription factor activity
D1115_12980	COG0730	response to heat
D1115_12985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1115_12990	COG0505	Belongs to the CarA family
D1115_13000	COG0494	nUDIX hydrolase
D1115_13015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D1115_13020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1115_13025	COG0849	cell division
D1115_13030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1115_13045	COG0772	Belongs to the SEDS family
D1115_13055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1115_13060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1115_13065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1115_13070	COG0768	penicillin binding
D1115_13075	COG3116	cell division
D1115_13095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1115_13110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1115_13115	COG2823	Periplasmic or secreted lipoprotein
D1115_13120	COG2969	positive regulation of protein catabolic process
D1115_13125	COG0625	glutathione transferase activity
D1115_13130	COG2857	Cytochrome c1
D1115_13135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1115_13140	COG0723	plastoquinol--plastocyanin reductase activity
D1115_13160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1115_13165	COG3105	Protein conserved in bacteria
D1115_13180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1115_13185	COG0187	DNA topoisomerase II activity
D1115_13190	COG3150	esterase
D1115_13200	COG3151	Protein conserved in bacteria
D1115_13205	COG0494	nUDIX hydrolase
D1115_13210	COG1538	Outer membrane efflux protein
D1115_13220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1115_13230	COG3025	triphosphatase activity
D1115_13235	COG1392	Phosphate transport regulator
D1115_13240	COG0306	phosphate transporter
D1115_13245	COG4991	sh3 domain protein
D1115_13255	COG3267	Type II secretory pathway component ExeA
D1115_13255	COG3409	Peptidoglycan-binding domain 1 protein
D1115_13270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1115_13275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1115_13280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1115_13285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1115_13290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1115_13295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1115_13300	COG1610	YqeY-like protein
D1115_13310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1115_13330	COG0730	response to heat
D1115_13365	COG3833	ABC-type maltose transport systems, permease component
D1115_13370	COG1175	transmembrane transport
D1115_13375	COG2182	Extracellular solute-binding protein
D1115_13385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1115_13390	COG3842	ATPase activity
D1115_13400	COG0641	radical SAM
D1115_13410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1115_13415	COG1349	DNA-binding transcription factor activity
D1115_13420	COG0469	pyruvate kinase activity
D1115_13440	COG0028	Belongs to the TPP enzyme family
D1115_13450	COG0583	DNA-binding transcription factor activity
D1115_13475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1115_13480	COG0473	3-isopropylmalate dehydrogenase activity
D1115_13500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1115_13505	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1115_13510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1115_13525	COG2967	ApaG domain
D1115_13535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1115_13540	COG3610	response to peptide
D1115_13545	COG2966	Psort location CytoplasmicMembrane, score
D1115_13550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1115_13560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1115_13565	COG0142	geranyltranstransferase activity
D1115_13605	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D1115_13610	COG1178	ABC-type Fe3 transport system permease component
D1115_13615	COG4143	(ABC) transporter
D1115_13620	COG0163	prenyltransferase activity
D1115_13625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1115_13630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D1115_13635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1115_13640	COG2105	PFAM AIG2 family protein
D1115_13650	COG0729	surface antigen
D1115_13655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_13665	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D1115_13680	COG4181	ATPase activity
D1115_13700	COG0529	Catalyzes the synthesis of activated sulfate
D1115_13705	COG3273	potassium ion transport
D1115_13705	COG0471	metal ion transport
D1115_13720	COG1648	precorrin-2 dehydrogenase activity
D1115_13720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1115_13725	COG0737	Belongs to the 5'-nucleotidase family
D1115_13735	COG0513	Belongs to the DEAD box helicase family
D1115_13740	COG2153	protein acetylation
D1115_13750	COG0545	Peptidyl-prolyl cis-trans isomerase
D1115_13760	COG0203	ribosomal protein L17
D1115_13775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1115_13780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1115_13790	COG0201	protein transport
D1115_13800	COG1841	ribosomal large subunit assembly
D1115_13815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1115_13825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1115_13830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1115_13840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1115_13845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1115_13875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1115_13885	COG0088	Forms part of the polypeptide exit tunnel
D1115_13900	COG0254	rRNA binding
D1115_13905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1115_13910	COG1609	Transcriptional regulator
D1115_13935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1115_13945	COG1494	fructose-1,6-bisphosphatase
D1115_13975	COG0149	triose-phosphate isomerase activity
D1115_13995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1115_14050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1115_14070	COG0438	transferase activity, transferring glycosyl groups
D1115_14085	COG1216	Glycosyl transferase, family 2
D1115_14120	COG0438	transferase activity, transferring glycosyl groups
D1115_14235	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_14245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1115_14270	COG3642	lipopolysaccharide core region biosynthetic process
D1115_14275	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1115_14280	COG0859	PFAM glycosyl transferase family 9
D1115_14285	COG0463	Glycosyl transferase, family 2
D1115_14315	COG2194	sulfuric ester hydrolase activity
D1115_14325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1115_14335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1115_14355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1115_14360	COG1561	YicC-like family, N-terminal region
D1115_14385	COG4608	Belongs to the ABC transporter superfamily
D1115_14390	COG0444	Belongs to the ABC transporter superfamily
D1115_14395	COG0747	negative chemotaxis
D1115_14400	COG4239	(ABC) transporter, permease
D1115_14405	COG4174	ABC transporter (Permease)
D1115_14425	COG0811	peptide transport
D1115_14430	COG0848	biopolymer transport protein
D1115_14445	COG0194	GDP metabolic process
D1115_14450	COG1758	RNA polymerase activity
D1115_14455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1115_14460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1115_14465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1115_14470	COG4946	Tricorn protease homolog
D1115_14470	COG1506	peptidase
D1115_14470	COG0823	Involved in the tonB-independent uptake of proteins
D1115_14475	COG2233	PERMEase
D1115_14485	COG0745	RESPONSE REGULATOR receiver
D1115_14500	COG2183	response to ionizing radiation
D1115_14515	COG1040	competence protein
D1115_14530	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1115_14540	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D1115_14545	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D1115_14550	COG3156	type II secretion system protein K
D1115_14555	COG4795	General secretion pathway protein
D1115_14570	COG2165	general secretion pathway protein
D1115_14575	COG1459	type II secretion system
D1115_14580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1115_14595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1115_14615	COG0456	acetyltransferase
D1115_14620	COG1490	D-aminoacyl-tRNA deacylase activity
D1115_14645	COG0174	glutamine synthetase
D1115_14655	COG3852	Histidine kinase
D1115_14660	COG2204	response regulator
D1115_14670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1115_14675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1115_14705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1115_14715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1115_14715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1115_14735	COG0084	hydrolase, TatD family'
D1115_14740	COG0805	protein transport
D1115_14745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1115_14760	COG3165	ubiquinone biosynthetic process from chorismate
D1115_14770	COG1322	Protein conserved in bacteria
D1115_14780	COG5001	Diguanylate cyclase
D1115_14780	COG3300	MHYT domain
D1115_14785	COG2081	HI0933 family
D1115_14795	COG1528	Iron-storage protein
D1115_14805	COG0697	spore germination
D1115_14820	COG1522	sequence-specific DNA binding
D1115_14825	COG0339	signal peptide processing
D1115_14830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1115_14835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1115_14840	COG0800	Aldolase
D1115_14845	COG2610	gluconate transmembrane transporter activity
D1115_14850	COG3265	gluconokinase activity
D1115_14855	COG0129	dihydroxy-acid dehydratase activity
D1115_14865	COG2076	Multidrug Resistance protein
D1115_14870	COG0583	DNA-binding transcription factor activity
D1115_14875	COG1609	Transcriptional regulator
D1115_14910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1115_14920	COG0747	negative chemotaxis
D1115_14925	COG4172	Belongs to the ABC transporter superfamily
D1115_14975	COG1309	transcriptional regulator
D1115_14980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_14985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_14995	COG2960	long-chain fatty acid transporting porin activity
D1115_15000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1115_15075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1115_15115	COG0569	domain protein
D1115_15130	COG1272	protein, Hemolysin III
D1115_15145	COG3084	Protein conserved in bacteria
D1115_15175	COG0606	chelatase, subunit chli
D1115_15185	COG3978	acetolactate synthase activity
D1115_15190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1115_15195	COG0129	dihydroxy-acid dehydratase activity
D1115_15210	COG2814	Major facilitator Superfamily
D1115_15220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1115_15225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1115_15230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1115_15235	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1115_15245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1115_15260	COG3312	ion transport
D1115_15265	COG1475	DNA binding
D1115_15270	COG1192	Involved in chromosome partitioning
D1115_15280	COG0445	tRNA wobble uridine modification
D1115_15310	COG0772	Belongs to the SEDS family
D1115_15320	COG1566	PFAM secretion protein HlyD family protein
D1115_15325	COG0583	DNA-binding transcription factor activity
D1115_15335	COG1136	(ABC) transporter
D1115_15355	COG3275	phosphorelay sensor kinase activity
D1115_15360	COG3279	Response regulator of the LytR AlgR family
D1115_15370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1115_15390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1115_15395	COG1999	signal sequence binding
D1115_15435	COG0786	glutamate:sodium symporter activity
D1115_15445	COG1131	(ABC) transporter
D1115_15450	COG0786	glutamate:sodium symporter activity
D1115_15475	COG3119	arylsulfatase activity
D1115_15485	COG0191	fructose-bisphosphate aldolase activity
D1115_15490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_15495	COG0800	Aldolase
D1115_15525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_15540	COG1566	PFAM secretion protein HlyD family protein
D1115_15600	COG3119	arylsulfatase activity
D1115_15605	COG1349	DNA-binding transcription factor activity
D1115_15620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_15625	COG3715	PTS system
D1115_15630	COG3716	PTS system mannose fructose sorbose family IID component
D1115_15635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_15650	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_15695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D1115_15700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1115_15710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1115_15740	COG3123	guanosine phosphorylase activity
D1115_15755	COG4932	domain protein
D1115_15755	COG4886	Leucine-rich repeat (LRR) protein
D1115_15770	COG2211	Major facilitator Superfamily
D1115_15810	COG0747	negative chemotaxis
D1115_15820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1115_15825	COG0444	Belongs to the ABC transporter superfamily
D1115_15830	COG4608	Belongs to the ABC transporter superfamily
D1115_15840	COG1609	Transcriptional regulator
D1115_15850	COG1609	Transcriptional regulator
D1115_15860	COG1472	Belongs to the glycosyl hydrolase 3 family
D1115_15865	COG0534	Mate efflux family protein
D1115_15870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1115_15875	COG0564	pseudouridine synthase activity
D1115_15880	COG0561	phosphatase activity
D1115_15890	COG2199	diguanylate cyclase activity
D1115_15900	COG3152	Membrane
D1115_15910	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1115_15915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D1115_15920	COG0583	DNA-binding transcription factor activity
D1115_15945	COG2076	Multidrug Resistance protein
D1115_15975	COG2814	Major facilitator Superfamily
D1115_16045	COG3005	denitrification pathway
D1115_16050	COG0243	molybdopterin cofactor binding
D1115_16070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1115_16075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1115_16080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1115_16085	COG1116	anion transmembrane transporter activity
D1115_16090	COG0351	phosphomethylpyrimidine kinase
D1115_16095	COG0312	modulator of DNA gyrase
D1115_16100	COG0312	modulator of DNA gyrase
D1115_16165	COG4974	Belongs to the 'phage' integrase family
D1115_16260	COG0584	glycerophosphoryl diester phosphodiesterase
D1115_16265	COG0745	RESPONSE REGULATOR receiver
D1115_16285	COG0811	peptide transport
D1115_16290	COG0811	peptide transport
D1115_16295	COG0848	biopolymer transport protein
D1115_16320	COG1770	oligopeptidase
D1115_16325	COG2814	Major facilitator Superfamily
D1115_16330	COG0010	Belongs to the arginase family
D1115_16335	COG1166	arginine decarboxylase activity
D1115_16345	COG4067	protein conserved in archaea
D1115_16345	COG0189	ligase activity
D1115_16350	COG0189	ligase activity
D1115_16355	COG0583	DNA-binding transcription factor activity
D1115_16380	COG2204	response regulator
D1115_16390	COG1114	Component of the transport system for branched-chain amino acids
D1115_16405	COG0579	oxidoreductase
D1115_16420	COG3033	Beta-eliminating lyase
D1115_16440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_16470	COG3706	GGDEF domain
D1115_16475	COG0415	Belongs to the DNA photolyase family
D1115_16480	COG3046	protein related to deoxyribodipyrimidine photolyase
D1115_16495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_16495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_16500	COG1765	OsmC-like protein
D1115_16505	COG2171	N-acyltransferase activity
D1115_16515	COG1011	Hydrolase
D1115_16535	COG3264	Mechanosensitive ion channel
D1115_16535	COG1511	domain protein
D1115_16540	COG2866	Carboxypeptidase
D1115_16565	COG1760	l-serine dehydratase
D1115_16590	COG0741	lytic transglycosylase activity
D1115_16590	COG1388	LysM domain
D1115_16610	COG1815	bacterial-type flagellum-dependent cell motility
D1115_16615	COG1558	bacterial-type flagellum-dependent cell motility
D1115_16620	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D1115_16625	COG1749	Flagellar hook protein flgE
D1115_16635	COG4786	Flagellar basal body rod
D1115_16640	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D1115_16645	COG1706	bacterial-type flagellum-dependent cell motility
D1115_16655	COG1256	bacterial-type flagellum assembly
D1115_16655	COG4786	Flagellar basal body rod
D1115_16725	COG1360	Flagellar Motor Protein
D1115_16730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D1115_16735	COG1191	sigma factor activity
D1115_16740	COG1580	Controls the rotational direction of flagella during chemotaxis
D1115_16760	COG1516	flagellar protein fliS
D1115_16765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D1115_16780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_16805	COG1987	bacterial-type flagellum assembly
D1115_16830	COG2204	response regulator
D1115_16835	COG1677	Flagellar hook-basal body complex protein FliE
D1115_16845	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D1115_16925	COG0156	8-amino-7-oxononanoate synthase activity
D1115_16930	COG1063	alcohol dehydrogenase
D1115_16935	COG0582	viral genome integration into host DNA
D1115_16990	COG3335	DDE superfamily endonuclease
D1115_17010	COG1349	DNA-binding transcription factor activity
D1115_17015	COG2084	Dehydrogenase
D1115_17020	COG3395	kinase activity
D1115_17025	COG0235	Class ii aldolase
D1115_17030	COG3622	Belongs to the hyi family
D1115_17035	COG2610	gluconate transmembrane transporter activity
D1115_17045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1115_17050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1115_17055	COG2356	endonuclease I
D1115_17090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D1115_17130	COG0668	transmembrane transport
D1115_17140	COG1304	FMN binding
D1115_17145	COG0583	DNA-binding transcription factor activity
D1115_17155	COG1067	ATP-dependent peptidase activity
D1115_17175	COG0437	4 iron, 4 sulfur cluster binding
D1115_17180	COG0348	domain, Protein
D1115_17185	COG0640	Transcriptional regulator
D1115_17210	COG1566	PFAM secretion protein HlyD family protein
D1115_17240	COG0813	purine-nucleoside phosphorylase activity
D1115_17245	COG3272	Protein of unknown function (DUF1722)
D1115_17255	COG0415	Belongs to the DNA photolyase family
D1115_17260	COG1376	ErfK ybiS ycfS ynhG family protein
D1115_17260	COG1388	LysM domain
D1115_17270	COG0513	Belongs to the DEAD box helicase family
D1115_17275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D1115_17280	COG0573	inorganic phosphate transmembrane transporter activity
D1115_17285	COG0581	inorganic phosphate transmembrane transporter activity
D1115_17295	COG3706	GGDEF domain
D1115_17325	COG0714	Associated with various cellular activities
D1115_17330	COG0840	transmembrane signaling receptor activity
D1115_17345	COG0110	maltose O-acetyltransferase activity
D1115_17350	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_17355	COG2203	Gaf domain
D1115_17355	COG3706	GGDEF domain
D1115_17355	COG4251	negative regulation of phosphorylation
D1115_17355	COG5001	Diguanylate cyclase
D1115_17380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D1115_17385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D1115_17390	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D1115_17405	COG1252	NADH dehydrogenase
D1115_17410	COG1301	dicarboxylic acid transport
D1115_17415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1115_17420	COG2706	6-phosphogluconolactonase activity
D1115_17425	COG1881	PFAM PEBP family protein
D1115_17435	COG0798	PFAM Bile acid sodium symporter
D1115_17445	COG0814	amino acid
D1115_17480	COG0739	heme binding
D1115_17490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_17495	COG0697	spore germination
D1115_17510	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1115_17515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1115_17520	COG1280	lysine exporter protein (LysE YggA)
D1115_17525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1115_17540	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D1115_17545	COG1845	cytochrome c oxidase, subunit III
D1115_17565	COG1612	heme a metabolic process
D1115_17585	COG0840	transmembrane signaling receptor activity
D1115_17590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1115_17615	COG2897	thiosulfate sulfurtransferase activity
D1115_17640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1115_17645	COG0303	'Molybdopterin
D1115_17655	COG1914	H( )-stimulated, divalent metal cation uptake system
D1115_17680	COG4989	oxidoreductase activity
D1115_17695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1115_17695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1115_17705	COG1247	-acetyltransferase
D1115_17720	COG1566	PFAM secretion protein HlyD family protein
D1115_17730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1115_17735	COG0076	glutamate decarboxylase activity
D1115_17765	COG4176	ABC-type proline glycine betaine transport system permease component
D1115_17770	COG4175	Glycine betaine
D1115_17770	COG0517	IMP dehydrogenase activity
D1115_17795	COG5001	Diguanylate cyclase
D1115_17795	COG3300	MHYT domain
D1115_17910	COG1045	serine acetyltransferase
D1115_17925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1115_17985	COG1794	racemase activity, acting on amino acids and derivatives
D1115_17990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1115_18005	COG0738	Major facilitator superfamily
D1115_18015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_18030	COG0789	Transcriptional regulator
D1115_18055	COG1289	transmembrane transporter activity
D1115_18070	COG1879	ABC-type sugar transport system periplasmic component
D1115_18075	COG2198	Histidine kinase
D1115_18075	COG2205	protein histidine kinase activity
D1115_18075	COG0784	Response regulator, receiver
D1115_18090	COG3119	arylsulfatase activity
D1115_18095	COG3119	arylsulfatase activity
D1115_18100	COG3063	Type IV pilus biogenesis stability protein PilW
D1115_18105	COG0714	Associated with various cellular activities
D1115_18140	COG0583	DNA-binding transcription factor activity
D1115_18145	COG3111	PFAM Bacterial OB fold (BOF) protein
D1115_18165	COG0641	radical SAM
D1115_18190	COG3069	C4-dicarboxylate transmembrane transporter activity
D1115_18210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1115_18275	COG0778	Nitroreductase
D1115_18280	COG0835	chemotaxis
D1115_18280	COG0784	Response regulator, receiver
D1115_18300	COG2962	Rard protein
D1115_18315	COG0671	phosphoesterase, PA-phosphatase related
D1115_18320	COG2076	Multidrug Resistance protein
D1115_18345	COG1902	pentaerythritol trinitrate reductase activity
D1115_18350	COG0346	lactoylglutathione lyase activity
D1115_18360	COG0420	3'-5' exonuclease activity
D1115_18365	COG0419	ATPase involved in DNA repair
D1115_18375	COG3469	chitinase activity
D1115_18395	COG3040	lipid binding
D1115_18420	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_18480	COG0509	glycine decarboxylation via glycine cleavage system
D1115_18485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1115_18525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_18525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_18525	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D1115_18530	COG1105	Belongs to the carbohydrate kinase PfkB family
D1115_18535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_18535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_18540	COG1609	Transcriptional regulator
D1115_18555	COG0765	amino acid transport
D1115_18560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_18565	COG0765	amino acid transport
D1115_18570	COG1126	abc transporter atp-binding protein
D1115_18575	COG1979	alcohol dehydrogenase
D1115_18580	COG2207	Transcriptional regulator
D1115_18595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_18625	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D1115_18630	COG0513	Belongs to the DEAD box helicase family
D1115_18645	COG3038	cytochrome b561
D1115_18655	COG2116	formate transmembrane transporter activity
D1115_18660	COG0583	DNA-binding transcription factor activity
D1115_18670	COG3593	DNA synthesis involved in DNA repair
D1115_18675	COG0737	Belongs to the 5'-nucleotidase family
D1115_18680	COG0861	Integral membrane protein TerC family
D1115_18700	COG2267	carboxylic ester hydrolase activity
D1115_18705	COG2067	long-chain fatty acid transport protein
D1115_18720	COG2050	protein possibly involved in aromatic compounds catabolism
D1115_18730	COG4533	DNA binding
D1115_18755	COG0484	heat shock protein binding
D1115_18770	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1115_18785	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D1115_18795	COG1984	allophanate hydrolase subunit 2
D1115_18800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1115_18810	COG5001	Diguanylate cyclase
D1115_18810	COG3447	MASE1 domain protein
D1115_18810	COG5002	protein histidine kinase activity
D1115_18830	COG0583	DNA-binding transcription factor activity
D1115_18835	COG0045	succinate-CoA ligase (ADP-forming) activity
D1115_18835	COG1042	CoA-binding domain protein
D1115_18835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1115_18855	COG0023	Translation Initiation Factor
D1115_18865	COG3140	Belongs to the UPF0181 family
D1115_18890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1115_18895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1115_18910	COG3706	GGDEF domain
D1115_18910	COG0745	RESPONSE REGULATOR receiver
D1115_18920	COG5001	Diguanylate cyclase
D1115_18920	COG4251	negative regulation of phosphorylation
D1115_18920	COG2203	Gaf domain
D1115_18920	COG3706	GGDEF domain
D1115_18930	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1115_18935	COG4149	molybdate abc transporter
D1115_18940	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1115_18950	COG3111	PFAM Bacterial OB fold (BOF) protein
D1115_18975	COG0534	Mate efflux family protein
D1115_18980	COG0602	queuosine metabolic process
D1115_18985	COG1328	CTP reductase activity
D1115_19060	COG0628	permease
D1115_19070	COG1566	PFAM secretion protein HlyD family protein
D1115_19085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1115_19090	COG3118	belongs to the thioredoxin family
D1115_19095	COG2814	Major facilitator Superfamily
D1115_19130	COG2116	formate transmembrane transporter activity
D1115_19135	COG2146	nitrite reductase [NAD(P)H] activity
D1115_19140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1115_19145	COG3706	GGDEF domain
D1115_19195	COG0277	FAD linked oxidase domain protein
D1115_19205	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D1115_19220	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D1115_19230	COG1288	antiporter activity
D1115_19285	COG2826	transposase and inactivated derivatives, IS30 family
D1115_19340	COG1132	(ABC) transporter
D1115_19375	COG0318	PFAM AMP-dependent synthetase and ligase
D1115_19385	COG4771	TonB-dependent receptor
D1115_19410	COG0628	permease
D1115_19450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1115_19450	COG2146	nitrite reductase [NAD(P)H] activity
D1115_19455	COG1116	anion transmembrane transporter activity
D1115_19460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1115_19465	COG1116	anion transmembrane transporter activity
D1115_19465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1115_19475	COG3707	response regulator
D1115_19490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1115_19490	COG1648	precorrin-2 dehydrogenase activity
D1115_19495	COG0243	molybdopterin cofactor binding
D1115_19505	COG0814	amino acid
D1115_19530	COG1785	Belongs to the alkaline phosphatase family
D1115_19535	COG5002	protein histidine kinase activity
D1115_19540	COG0745	RESPONSE REGULATOR receiver
D1115_19560	COG0443	Heat shock 70 kDa protein
D1115_19575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1115_19610	COG3976	FMN-binding domain protein
D1115_19610	COG1053	succinate dehydrogenase
D1115_19610	COG0431	NADPH-dependent FMN reductase
D1115_19615	COG0625	glutathione transferase activity
D1115_19635	COG4160	amino acid transport
D1115_19640	COG4215	(ABC) transporter
D1115_19645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_19650	COG1126	abc transporter atp-binding protein
D1115_19665	COG1902	pentaerythritol trinitrate reductase activity
D1115_19665	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1115_19680	COG1024	Enoyl-CoA hydratase
D1115_19685	COG1024	Enoyl-CoA hydratase
D1115_19690	COG1960	acyl-CoA dehydrogenase activity
D1115_19705	COG1960	acyl-CoA dehydrogenase activity
D1115_19710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1115_19715	COG1024	Enoyl-CoA hydratase
D1115_19735	COG3278	Belongs to the heme-copper respiratory oxidase family
D1115_19825	COG0444	Belongs to the ABC transporter superfamily
D1115_19845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1115_19870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D1115_19915	COG3706	GGDEF domain
D1115_19920	COG2252	PERMEase
D1115_19925	COG1119	ATPase activity
D1115_19945	COG0513	Belongs to the DEAD box helicase family
D1115_19985	COG3416	Protein conserved in bacteria
D1115_20000	COG3530	Putative quorum-sensing-regulated virulence factor
D1115_20030	COG3186	Phenylalanine-4-hydroxylase
D1115_20035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1115_20040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1115_20060	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D1115_20065	COG1454	alcohol dehydrogenase
D1115_20070	COG2133	pyrroloquinoline quinone binding
D1115_20080	COG0783	Belongs to the Dps family
D1115_20090	COG0840	transmembrane signaling receptor activity
D1115_20100	COG0577	efflux transmembrane transporter activity
D1115_20100	COG1136	(ABC) transporter
D1115_20105	COG1136	(ABC) transporter
D1115_20105	COG0577	efflux transmembrane transporter activity
D1115_20120	COG1278	Cold shock
D1115_20150	COG0545	Peptidyl-prolyl cis-trans isomerase
D1115_20175	COG2197	response regulator
D1115_20180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1115_20190	COG0840	transmembrane signaling receptor activity
D1115_20210	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1115_20225	COG2197	response regulator
D1115_20230	COG3850	Histidine kinase
D1115_20235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1115_20255	COG3005	denitrification pathway
D1115_20275	COG0183	Belongs to the thiolase family
D1115_20285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_20290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_20335	COG2827	Endonuclease containing a URI domain
D1115_20380	COG0583	DNA-binding transcription factor activity
D1115_20415	COG1566	PFAM secretion protein HlyD family protein
D1115_20420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1115_20425	COG2239	Acts as a magnesium transporter
D1115_20430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D1115_20435	COG0402	S-adenosylhomocysteine deaminase activity
D1115_20450	COG1418	mRNA catabolic process
D1115_20460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1115_20475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1115_20490	COG4221	oxidoreductase activity
D1115_20495	COG0745	RESPONSE REGULATOR receiver
D1115_20500	COG2205	protein histidine kinase activity
D1115_20510	COG2194	sulfuric ester hydrolase activity
D1115_20525	COG2814	Major facilitator Superfamily
D1115_20540	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_20555	COG0583	DNA-binding transcription factor activity
D1115_20580	COG0366	Alpha amylase catalytic
D1115_20585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1115_20590	COG2205	protein histidine kinase activity
D1115_20590	COG0784	Response regulator, receiver
D1115_20600	COG0748	coenzyme F420 binding
D1115_20620	COG0811	peptide transport
D1115_20625	COG0848	biopolymer transport protein
D1115_20635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1115_20640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D1115_20680	COG2186	Transcriptional regulator
D1115_20700	COG0633	Ferredoxin
D1115_20700	COG3217	Mosc domain protein beta barrel domain protein
D1115_20700	COG0633	Ferredoxin
D1115_20700	COG3217	Mosc domain protein beta barrel domain protein
D1115_20705	COG0401	homolog of Blt101
D1115_20720	COG2354	Protein conserved in bacteria
D1115_20800	COG0741	lytic transglycosylase activity
D1115_20845	COG3833	ABC-type maltose transport systems, permease component
D1115_20850	COG1175	transmembrane transport
D1115_20865	COG3842	ATPase activity
D1115_20875	COG1309	transcriptional regulator
D1115_20880	COG2130	NADP-dependent
D1115_20890	COG0753	catalase activity
D1115_20895	COG2084	Dehydrogenase
D1115_20905	COG0583	DNA-binding transcription factor activity
D1115_20910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_20915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_20925	COG2207	Transcriptional regulator
D1115_20930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_20930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_20930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_20935	COG1482	cell wall glycoprotein biosynthetic process
D1115_20950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D1115_20960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_20965	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_20975	COG0402	S-adenosylhomocysteine deaminase activity
D1115_20990	COG3383	formate dehydrogenase (NAD+) activity
D1115_21010	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_21040	COG0456	acetyltransferase
D1115_21050	COG0494	nUDIX hydrolase
D1115_21055	COG1505	serine-type exopeptidase activity
D1115_21065	COG0589	response to stress
D1115_21105	COG4667	esterase of the alpha-beta hydrolase superfamily
D1115_21110	COG1741	Belongs to the pirin family
D1115_21115	COG1278	Cold shock
D1115_21130	COG0678	peroxiredoxin activity
D1115_21130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_21140	COG1686	Belongs to the peptidase S11 family
D1115_21145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_21150	COG0625	glutathione transferase activity
D1115_21160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1115_21165	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_21180	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_21190	COG0583	DNA-binding transcription factor activity
D1115_21195	COG2207	Transcriptional regulator
D1115_21195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1115_21200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1115_21225	COG0513	Belongs to the DEAD box helicase family
D1115_21245	COG0589	response to stress
D1115_21250	COG3122	Protein conserved in bacteria
D1115_21265	COG0583	DNA-binding transcription factor activity
D1115_21275	COG1335	isochorismatase
D1115_21280	COG1881	PFAM PEBP family protein
D1115_21300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D1115_21305	COG0574	Belongs to the PEP-utilizing enzyme family
D1115_21305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1115_21315	COG3302	dmso reductase anchor subunit
D1115_21320	COG0437	4 iron, 4 sulfur cluster binding
D1115_21325	COG0243	molybdopterin cofactor binding
D1115_21330	COG3381	protein complex oligomerization
D1115_21345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1115_21360	COG0786	glutamate:sodium symporter activity
D1115_21375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_21415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1115_21450	COG3710	Transcriptional regulator
D1115_21460	COG3710	Transcriptional regulator
D1115_21480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1115_21500	COG1342	Belongs to the UPF0251 family
D1115_21510	COG4176	ABC-type proline glycine betaine transport system permease component
D1115_21515	COG3448	diguanylate cyclase activity
D1115_21515	COG4175	Glycine betaine
D1115_21520	COG3015	lipoprotein NlpE involved in copper resistance
D1115_21525	COG0583	DNA-binding transcription factor activity
D1115_21585	COG0346	lactoylglutathione lyase activity
D1115_21600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_21605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1115_21610	COG0583	DNA-binding transcription factor activity
D1115_21630	COG4628	conserved protein (DUF2132)
D1115_21635	COG0488	(ABC) transporter
D1115_21670	COG0628	permease
D1115_21675	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D1115_21685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1115_21700	COG4628	conserved protein (DUF2132)
D1115_21705	COG0583	DNA-binding transcription factor activity
D1115_21715	COG0583	DNA-binding transcription factor activity
D1115_21725	COG1234	tRNA 3'-trailer cleavage
D1115_21740	COG1686	Belongs to the peptidase S11 family
D1115_21755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1115_21765	COG3397	chitin binding
D1115_21780	COG0840	transmembrane signaling receptor activity
D1115_21785	COG4667	esterase of the alpha-beta hydrolase superfamily
D1115_21790	COG2095	MarC family integral membrane protein
D1115_21795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1115_21840	COG1301	dicarboxylic acid transport
D1115_21845	COG3339	Conserved Protein
D1115_21850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1115_21855	COG0700	Nucleoside recognition
D1115_21860	COG3366	ferrous iron transmembrane transporter activity
D1115_21865	COG0366	Alpha amylase catalytic
D1115_21870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1115_21875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1115_21880	COG1640	4-alpha-glucanotransferase
D1115_21885	COG0058	SHG alpha-glucan phosphorylase activity
D1115_21920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_21920	COG1263	PTS System
D1115_21925	COG1162	GTPase activity
D1115_21930	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D1115_21945	COG0531	amino acid
D1115_21950	COG1982	Orn Lys Arg decarboxylase major
D1115_21970	COG0366	Alpha amylase catalytic
D1115_21985	COG4580	involved in the transport of maltose and maltodextrins
D1115_21995	COG3706	GGDEF domain
D1115_22015	COG4771	TonB-dependent receptor
D1115_22020	COG0583	DNA-binding transcription factor activity
D1115_22025	COG4607	ABC-type enterochelin transport system periplasmic component
D1115_22030	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1115_22035	COG4605	iron ion homeostasis
D1115_22040	COG4604	ABC transporter, ATP-binding protein
D1115_22075	COG0583	DNA-binding transcription factor activity
D1115_22080	COG0583	DNA-binding transcription factor activity
D1115_22085	COG0657	acetylesterase activity
D1115_22110	COG1136	(ABC) transporter
D1115_22140	COG0450	alkyl hydroperoxide reductase
D1115_22145	COG3634	alkyl hydroperoxide reductase activity
D1115_22150	COG1278	Cold shock
D1115_22155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1115_22160	COG1522	sequence-specific DNA binding
D1115_22165	COG0006	proline dipeptidase activity
D1115_22195	COG0596	Alpha beta hydrolase
D1115_22200	COG0596	Alpha beta hydrolase
D1115_22205	COG0513	Belongs to the DEAD box helicase family
D1115_22220	COG0583	DNA-binding transcription factor activity
D1115_22225	COG1312	Catalyzes the dehydration of D-mannonate
D1115_22230	COG0246	Mannitol dehydrogenase
D1115_22235	COG1904	glucuronate isomerase
D1115_22240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_22245	COG0800	Aldolase
D1115_22265	COG3250	beta-galactosidase activity
D1115_22275	COG2186	Transcriptional regulator
D1115_22330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_22410	COG1444	tRNA N-acetyltransferase activity
D1115_22425	COG1192	Involved in chromosome partitioning
D1115_22435	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_22440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1115_22455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1115_22555	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D1115_22565	COG2111	Na H antiporter
D1115_22565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1115_22595	COG1320	monovalent cation:proton antiporter activity
D1115_22630	COG2188	Transcriptional regulator
D1115_22670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D1115_22675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1115_22685	COG1024	Enoyl-CoA hydratase
D1115_22690	COG1960	acyl-CoA dehydrogenase activity
D1115_22695	COG1960	acyl-CoA dehydrogenase activity
D1115_22700	COG0183	Belongs to the thiolase family
D1115_22705	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_22715	COG2161	toxin-antitoxin pair type II binding
D1115_22720	COG4115	mRNA cleavage
D1115_22725	COG0653	protein targeting
D1115_22760	COG1960	acyl-CoA dehydrogenase activity
D1115_22775	COG2086	electron transfer activity
D1115_22795	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_22820	COG1960	acyl-CoA dehydrogenase activity
D1115_22825	COG1960	acyl-CoA dehydrogenase activity
D1115_22845	COG0471	metal ion transport
D1115_22845	COG3273	potassium ion transport
D1115_22860	COG0574	Belongs to the PEP-utilizing enzyme family
D1115_22860	COG3848	Pyruvate phosphate dikinase
D1115_22865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1115_22880	COG2176	DNA-directed DNA polymerase activity
D1115_22895	COG0438	transferase activity, transferring glycosyl groups
D1115_22900	COG0438	transferase activity, transferring glycosyl groups
D1115_22905	COG0297	glycogen (starch) synthase activity
D1115_22910	COG0367	asparagine synthase
D1115_22985	COG2076	Multidrug Resistance protein
D1115_22990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1115_22990	COG0546	phosphoglycolate phosphatase activity
D1115_23020	COG0438	transferase activity, transferring glycosyl groups
D1115_23035	COG4974	Belongs to the 'phage' integrase family
D1115_23050	COG2204	response regulator
D1115_23090	COG1215	transferase activity, transferring glycosyl groups
D1115_23130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1115_23155	COG2963	transposase activity
D1115_23160	COG2801	Transposase and inactivated derivatives
D1115_23165	COG2801	Transposase and inactivated derivatives
D1115_23175	COG3706	GGDEF domain
D1115_23185	COG1024	Enoyl-CoA hydratase
D1115_23190	COG0183	Belongs to the thiolase family
D1115_23220	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_23225	COG1902	pentaerythritol trinitrate reductase activity
D1115_23230	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_23255	COG2814	Major facilitator Superfamily