locus-tag	class	description
AL539_00025	COG0631	protein serine/threonine phosphatase activity
AL539_00080	COG3501	Rhs element vgr protein
AL539_00095	COG0420	3'-5' exonuclease activity
AL539_00100	COG0419	ATPase involved in DNA repair
AL539_00110	COG3040	lipid binding
AL539_00120	COG1288	antiporter activity
AL539_00130	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL539_00145	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL539_00160	COG0583	DNA-binding transcription factor activity
AL539_00165	COG0277	FAD linked oxidase domain protein
AL539_00180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL539_00235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL539_00260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_00265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_00270	COG2146	nitrite reductase [NAD(P)H] activity
AL539_00275	COG2116	formate transmembrane transporter activity
AL539_00295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL539_00330	COG2814	Major facilitator Superfamily
AL539_00335	COG3118	belongs to the thioredoxin family
AL539_00340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL539_00365	COG2271	Major facilitator Superfamily
AL539_00370	COG3851	Histidine kinase
AL539_00375	COG2197	response regulator
AL539_00385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL539_00390	COG0583	DNA-binding transcription factor activity
AL539_00400	COG0243	molybdopterin cofactor binding
AL539_00415	COG0384	phenazine biosynthesis protein PhzF
AL539_00420	COG1794	racemase activity, acting on amino acids and derivatives
AL539_00455	COG1328	CTP reductase activity
AL539_00460	COG0602	queuosine metabolic process
AL539_00465	COG0534	Mate efflux family protein
AL539_00470	COG2207	Transcriptional regulator
AL539_00480	COG4067	protein conserved in archaea
AL539_00480	COG0189	ligase activity
AL539_00490	COG3111	PFAM Bacterial OB fold (BOF) protein
AL539_00500	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL539_00505	COG4149	molybdate abc transporter
AL539_00510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL539_00520	COG4251	negative regulation of phosphorylation
AL539_00520	COG2203	Gaf domain
AL539_00520	COG5001	Diguanylate cyclase
AL539_00520	COG3706	GGDEF domain
AL539_00525	COG0745	RESPONSE REGULATOR receiver
AL539_00525	COG3706	GGDEF domain
AL539_00555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL539_00560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL539_00585	COG3140	Belongs to the UPF0181 family
AL539_00600	COG0583	DNA-binding transcription factor activity
AL539_00620	COG0023	Translation Initiation Factor
AL539_00630	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL539_00640	COG0045	succinate-CoA ligase (ADP-forming) activity
AL539_00640	COG1042	CoA-binding domain protein
AL539_00640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_00645	COG0583	DNA-binding transcription factor activity
AL539_00665	COG5002	protein histidine kinase activity
AL539_00665	COG3447	MASE1 domain protein
AL539_00665	COG5001	Diguanylate cyclase
AL539_00670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL539_00675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL539_00680	COG1984	allophanate hydrolase subunit 2
AL539_00690	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL539_00695	COG4181	ATPase activity
AL539_00705	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL539_00710	COG5001	Diguanylate cyclase
AL539_00710	COG3300	MHYT domain
AL539_00745	COG4533	DNA binding
AL539_00755	COG2050	protein possibly involved in aromatic compounds catabolism
AL539_00770	COG2067	long-chain fatty acid transport protein
AL539_00775	COG2267	carboxylic ester hydrolase activity
AL539_00795	COG0861	Integral membrane protein TerC family
AL539_00800	COG0737	Belongs to the 5'-nucleotidase family
AL539_00805	COG3593	DNA synthesis involved in DNA repair
AL539_00815	COG0583	DNA-binding transcription factor activity
AL539_00820	COG2116	formate transmembrane transporter activity
AL539_00825	COG2353	YceI-like domain
AL539_00830	COG3038	cytochrome b561
AL539_00850	COG0513	Belongs to the DEAD box helicase family
AL539_00855	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL539_00865	COG0840	transmembrane signaling receptor activity
AL539_00875	COG0546	phosphoglycolate phosphatase activity
AL539_00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_00895	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL539_00900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL539_00915	COG2207	Transcriptional regulator
AL539_00920	COG1979	alcohol dehydrogenase
AL539_00930	COG1126	abc transporter atp-binding protein
AL539_00935	COG0765	amino acid transport
AL539_00940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_00945	COG0765	amino acid transport
AL539_00950	COG2203	Gaf domain
AL539_00950	COG2200	EAL domain
AL539_00950	COG2199	diguanylate cyclase activity
AL539_00965	COG1609	Transcriptional regulator
AL539_00970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_00970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_00975	COG1105	Belongs to the carbohydrate kinase PfkB family
AL539_00980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_00980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL539_00980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL539_01020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL539_01025	COG0509	glycine decarboxylation via glycine cleavage system
AL539_01035	COG0346	lactoylglutathione lyase activity
AL539_01045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL539_01050	COG0583	DNA-binding transcription factor activity
AL539_01055	COG0697	spore germination
AL539_01060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL539_01090	COG2176	DNA-directed DNA polymerase activity
AL539_01140	COG0242	peptide deformylase activity
AL539_01175	COG2239	Acts as a magnesium transporter
AL539_01195	COG0346	lactoylglutathione lyase activity
AL539_01200	COG1902	pentaerythritol trinitrate reductase activity
AL539_01210	COG2755	lipolytic protein G-D-S-L family
AL539_01210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AL539_01225	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL539_01230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL539_01230	COG0069	glutamate synthase activity
AL539_01260	COG2076	Multidrug Resistance protein
AL539_01280	COG2962	Rard protein
AL539_01295	COG0784	Response regulator, receiver
AL539_01295	COG0835	chemotaxis
AL539_01305	COG0745	RESPONSE REGULATOR receiver
AL539_01315	COG3706	GGDEF domain
AL539_01320	COG2197	response regulator
AL539_01325	COG3300	MHYT domain
AL539_01325	COG5001	Diguanylate cyclase
AL539_01330	COG0784	Response regulator, receiver
AL539_01330	COG2205	protein histidine kinase activity
AL539_01335	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL539_01355	COG0456	acetyltransferase
AL539_01355	COG1214	PFAM Peptidase M22, glycoprotease
AL539_01365	COG3069	C4-dicarboxylate transmembrane transporter activity
AL539_01390	COG3111	PFAM Bacterial OB fold (BOF) protein
AL539_01395	COG1597	lipid kinase activity
AL539_01400	COG0583	DNA-binding transcription factor activity
AL539_01405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL539_01435	COG0714	Associated with various cellular activities
AL539_01440	COG0641	radical SAM
AL539_01445	COG3119	arylsulfatase activity
AL539_01455	COG3119	arylsulfatase activity
AL539_01460	COG0745	RESPONSE REGULATOR receiver
AL539_01475	COG2198	Histidine kinase
AL539_01475	COG2205	protein histidine kinase activity
AL539_01475	COG0784	Response regulator, receiver
AL539_01480	COG1879	ABC-type sugar transport system periplasmic component
AL539_01485	COG1803	Methylglyoxal synthase
AL539_01490	COG0210	DNA helicase
AL539_01495	COG1289	transmembrane transporter activity
AL539_01530	COG4771	TonB-dependent receptor
AL539_01530	COG1629	transport
AL539_01540	COG0789	Transcriptional regulator
AL539_01545	COG4604	ABC transporter, ATP-binding protein
AL539_01550	COG4605	iron ion homeostasis
AL539_01555	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_01560	COG4607	ABC-type enterochelin transport system periplasmic component
AL539_01570	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL539_01585	COG1609	Transcriptional regulator
AL539_01590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_01595	COG1879	ABC-type sugar transport system periplasmic component
AL539_01600	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL539_01605	COG1129	ABC transporter
AL539_01610	COG1869	D-ribose catabolic process
AL539_01615	COG5001	Diguanylate cyclase
AL539_01670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL539_01680	COG2205	protein histidine kinase activity
AL539_01680	COG0784	Response regulator, receiver
AL539_01695	COG0330	HflC and HflK could
AL539_01710	COG4175	Glycine betaine
AL539_01710	COG0517	IMP dehydrogenase activity
AL539_01715	COG4176	ABC-type proline glycine betaine transport system permease component
AL539_01730	COG1012	belongs to the aldehyde dehydrogenase family
AL539_01735	COG1309	transcriptional regulator
AL539_01740	COG3706	GGDEF domain
AL539_01740	COG0745	RESPONSE REGULATOR receiver
AL539_01745	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_01760	COG1024	Enoyl-CoA hydratase
AL539_01765	COG1960	acyl-CoA dehydrogenase activity
AL539_01775	COG0183	Belongs to the thiolase family
AL539_01785	COG1960	acyl-CoA dehydrogenase activity
AL539_01790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL539_01815	COG3264	Mechanosensitive ion channel
AL539_01815	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL539_01825	COG0110	maltose O-acetyltransferase activity
AL539_01830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_01835	COG1271	oxidase subunit
AL539_01840	COG1294	oxidase, subunit
AL539_01855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL539_01865	COG3527	Alpha-acetolactate decarboxylase
AL539_01875	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_01880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_01910	COG0500	methyltransferase
AL539_01940	COG1022	Amp-dependent synthetase and ligase
AL539_01970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL539_01975	COG1263	PTS System
AL539_01975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_01980	COG1486	melibiose metabolic process
AL539_01985	COG2188	Transcriptional regulator
AL539_01990	COG1320	monovalent cation:proton antiporter activity
AL539_01995	COG2212	antiporter activity
AL539_02010	COG1006	Multisubunit Na H antiporter MnhC subunit
AL539_02015	COG2111	Na H antiporter
AL539_02015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL539_02025	COG0589	response to stress
AL539_02030	COG4221	oxidoreductase activity
AL539_02035	COG0583	DNA-binding transcription factor activity
AL539_02045	COG2814	Major facilitator Superfamily
AL539_02055	COG3179	chitinase
AL539_02100	COG1522	sequence-specific DNA binding
AL539_02135	COG0515	serine threonine protein kinase
AL539_02160	COG3501	Rhs element vgr protein
AL539_02200	COG0739	heme binding
AL539_02225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_02230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_02240	COG2207	Transcriptional regulator
AL539_02245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_02245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_02245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_02260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_02265	COG3537	Alpha-1,2-mannosidase
AL539_02270	COG3537	Alpha-1,2-mannosidase
AL539_02280	COG3537	Alpha-1,2-mannosidase
AL539_02285	COG3537	Alpha-1,2-mannosidase
AL539_02315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL539_02315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL539_02330	COG4989	oxidoreductase activity
AL539_02345	COG0038	chloride channel
AL539_02365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL539_02380	COG2897	thiosulfate sulfurtransferase activity
AL539_02400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL539_02405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL539_02415	COG2814	Major facilitator Superfamily
AL539_02420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL539_02435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL539_02445	COG0840	transmembrane signaling receptor activity
AL539_02465	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL539_02480	COG2197	response regulator
AL539_02485	COG3850	Histidine kinase
AL539_02490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL539_02500	COG0243	molybdopterin cofactor binding
AL539_02510	COG3005	denitrification pathway
AL539_02520	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL539_02530	COG0183	Belongs to the thiolase family
AL539_02540	COG1280	lysine exporter protein (LysE YggA)
AL539_02550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_02555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_02610	COG1846	Transcriptional regulator
AL539_02615	COG2205	protein histidine kinase activity
AL539_02615	COG0784	Response regulator, receiver
AL539_02620	COG1879	ABC-type sugar transport system periplasmic component
AL539_02630	COG2827	Endonuclease containing a URI domain
AL539_02635	COG3132	Protein of unknown function, DUF480
AL539_02655	COG0784	Response regulator, receiver
AL539_02655	COG2205	protein histidine kinase activity
AL539_02655	COG5002	protein histidine kinase activity
AL539_02695	COG0531	amino acid
AL539_02710	COG2205	protein histidine kinase activity
AL539_02715	COG0745	RESPONSE REGULATOR receiver
AL539_02745	COG1566	PFAM secretion protein HlyD family protein
AL539_02750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL539_02755	COG2239	Acts as a magnesium transporter
AL539_02760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL539_02765	COG0402	S-adenosylhomocysteine deaminase activity
AL539_02770	COG1418	mRNA catabolic process
AL539_02785	COG2814	Major facilitator Superfamily
AL539_02795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL539_02815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_02830	COG0745	RESPONSE REGULATOR receiver
AL539_02835	COG2205	protein histidine kinase activity
AL539_02845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL539_02850	COG2194	sulfuric ester hydrolase activity
AL539_02870	COG4667	esterase of the alpha-beta hydrolase superfamily
AL539_02875	COG1741	Belongs to the pirin family
AL539_02880	COG1278	Cold shock
AL539_02895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL539_02900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL539_02900	COG0678	peroxiredoxin activity
AL539_02910	COG1686	Belongs to the peptidase S11 family
AL539_02920	COG0625	glutathione transferase activity
AL539_02930	COG1621	beta-fructofuranosidase activity
AL539_02935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_02940	COG1263	PTS System
AL539_02940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_02965	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_02980	COG3746	phosphate-selective porin O and P
AL539_02995	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_03000	COG0583	DNA-binding transcription factor activity
AL539_03005	COG2207	Transcriptional regulator
AL539_03005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL539_03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_03040	COG0513	Belongs to the DEAD box helicase family
AL539_03050	COG0583	DNA-binding transcription factor activity
AL539_03065	COG1902	pentaerythritol trinitrate reductase activity
AL539_03070	COG1063	alcohol dehydrogenase
AL539_03080	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_03095	COG0006	proline dipeptidase activity
AL539_03100	COG3608	succinylglutamate desuccinylase aspartoacylase
AL539_03105	COG1522	sequence-specific DNA binding
AL539_03110	COG1012	belongs to the aldehyde dehydrogenase family
AL539_03115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL539_03120	COG3122	Protein conserved in bacteria
AL539_03135	COG0583	DNA-binding transcription factor activity
AL539_03145	COG0252	asparaginase activity
AL539_03150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL539_03165	COG2197	response regulator
AL539_03170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL539_03175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL539_03195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_03225	COG3842	ATPase activity
AL539_03245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_03275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL539_03280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL539_03315	COG0583	DNA-binding transcription factor activity
AL539_03325	COG4948	Mandelate Racemase Muconate Lactonizing
AL539_03335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL539_03360	COG1342	Belongs to the UPF0251 family
AL539_03370	COG4176	ABC-type proline glycine betaine transport system permease component
AL539_03375	COG3448	diguanylate cyclase activity
AL539_03375	COG4175	Glycine betaine
AL539_03380	COG3015	lipoprotein NlpE involved in copper resistance
AL539_03385	COG3713	MltA-interacting MipA family protein
AL539_03400	COG0583	DNA-binding transcription factor activity
AL539_03425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL539_03435	COG1335	isochorismatase
AL539_03450	COG1349	DNA-binding transcription factor activity
AL539_03455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_03455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_03460	COG2070	2-Nitropropane dioxygenase
AL539_03465	COG0531	amino acid
AL539_03470	COG4302	ethanolamine ammonia-lyase activity
AL539_03475	COG4303	Ethanolamine ammonia lyase large subunit
AL539_03485	COG1309	transcriptional regulator
AL539_03505	COG1280	lysine exporter protein (LysE YggA)
AL539_03515	COG0459	protein refolding
AL539_03520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL539_03525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_03540	COG1304	FMN binding
AL539_03565	COG4786	Flagellar basal body rod
AL539_03565	COG1256	bacterial-type flagellum assembly
AL539_03575	COG1706	bacterial-type flagellum-dependent cell motility
AL539_03580	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL539_03585	COG4786	Flagellar basal body rod
AL539_03590	COG4787	bacterial-type flagellum-dependent cell motility
AL539_03595	COG1749	Flagellar hook protein flgE
AL539_03600	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL539_03605	COG1558	bacterial-type flagellum-dependent cell motility
AL539_03610	COG1815	bacterial-type flagellum-dependent cell motility
AL539_03630	COG0741	lytic transglycosylase activity
AL539_03635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL539_03655	COG1760	l-serine dehydratase
AL539_03670	COG0583	DNA-binding transcription factor activity
AL539_03680	COG2866	Carboxypeptidase
AL539_03685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_03695	COG2990	Protein conserved in bacteria
AL539_03720	COG3842	ATPase activity
AL539_03725	COG1840	ABC-type Fe3 transport system, periplasmic component
AL539_03755	COG3240	lipase activity
AL539_03760	COG1309	transcriptional regulator
AL539_03775	COG1136	(ABC) transporter
AL539_03775	COG0577	efflux transmembrane transporter activity
AL539_03795	COG2067	long-chain fatty acid transport protein
AL539_03805	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL539_03820	COG1011	Hydrolase
AL539_03860	COG0110	maltose O-acetyltransferase activity
AL539_03865	COG1765	OsmC-like protein
AL539_03870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_03870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_03885	COG3046	protein related to deoxyribodipyrimidine photolyase
AL539_03890	COG0415	Belongs to the DNA photolyase family
AL539_03895	COG3706	GGDEF domain
AL539_03925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL539_03945	COG3033	Beta-eliminating lyase
AL539_03955	COG1271	oxidase subunit
AL539_03960	COG1294	oxidase, subunit
AL539_03975	COG0579	oxidoreductase
AL539_04000	COG3706	GGDEF domain
AL539_04030	COG0583	DNA-binding transcription factor activity
AL539_04055	COG0189	ligase activity
AL539_04060	COG0189	ligase activity
AL539_04060	COG4067	protein conserved in archaea
AL539_04070	COG1166	arginine decarboxylase activity
AL539_04075	COG0010	Belongs to the arginase family
AL539_04080	COG2814	Major facilitator Superfamily
AL539_04085	COG1770	oligopeptidase
AL539_04100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL539_04105	COG1121	(ABC) transporter
AL539_04110	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL539_04150	COG0848	biopolymer transport protein
AL539_04155	COG0811	peptide transport
AL539_04160	COG0811	peptide transport
AL539_04180	COG0745	RESPONSE REGULATOR receiver
AL539_04185	COG0584	glycerophosphoryl diester phosphodiesterase
AL539_04195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL539_04255	COG1901	pseudouridine methyltransferase
AL539_04260	COG0312	modulator of DNA gyrase
AL539_04265	COG0312	modulator of DNA gyrase
AL539_04270	COG0351	phosphomethylpyrimidine kinase
AL539_04275	COG1116	anion transmembrane transporter activity
AL539_04280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL539_04285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL539_04290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL539_04310	COG0243	molybdopterin cofactor binding
AL539_04315	COG3005	denitrification pathway
AL539_04320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_04325	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_04340	COG0456	acetyltransferase
AL539_04360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_04365	COG1929	Belongs to the glycerate kinase type-1 family
AL539_04370	COG2610	gluconate transmembrane transporter activity
AL539_04375	COG3835	regulator
AL539_04435	COG3047	cAMP biosynthetic process
AL539_04440	COG1357	PFAM Pentapeptide repeats (8 copies)
AL539_04470	COG2375	cellular response to nickel ion
AL539_04475	COG0583	DNA-binding transcription factor activity
AL539_04480	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL539_04485	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL539_04500	COG2199	diguanylate cyclase activity
AL539_04510	COG0561	phosphatase activity
AL539_04515	COG0583	DNA-binding transcription factor activity
AL539_04530	COG0564	pseudouridine synthase activity
AL539_04535	COG0534	Mate efflux family protein
AL539_04540	COG5001	Diguanylate cyclase
AL539_04550	COG3123	guanosine phosphorylase activity
AL539_04575	COG0596	Alpha beta hydrolase
AL539_04600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL539_04610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL539_04615	COG2169	Transcriptional regulator
AL539_04615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL539_04625	COG2259	Doxx family
AL539_04630	COG1741	Belongs to the pirin family
AL539_04650	COG0363	glucosamine-6-phosphate deaminase activity
AL539_04660	COG0786	glutamate:sodium symporter activity
AL539_04665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_04670	COG1131	(ABC) transporter
AL539_04680	COG0786	glutamate:sodium symporter activity
AL539_04705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL539_04715	COG3279	Response regulator of the LytR AlgR family
AL539_04720	COG3275	phosphorelay sensor kinase activity
AL539_04750	COG0772	Belongs to the SEDS family
AL539_04775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL539_04775	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AL539_04785	COG0444	Belongs to the ABC transporter superfamily
AL539_04790	COG4608	Belongs to the ABC transporter superfamily
AL539_04815	COG1444	tRNA N-acetyltransferase activity
AL539_04840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_04845	COG1263	PTS System
AL539_04845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_04850	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL539_04870	COG4166	transmembrane transport
AL539_04920	COG0259	pyridoxamine-phosphate oxidase activity
AL539_04945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL539_04985	COG1132	(ABC) transporter
AL539_04995	COG0513	Belongs to the DEAD box helicase family
AL539_05000	COG2258	MOSC domain
AL539_05055	COG3634	alkyl hydroperoxide reductase activity
AL539_05060	COG0450	alkyl hydroperoxide reductase
AL539_05065	COG1846	Transcriptional regulator
AL539_05070	COG1764	response to oxidative stress
AL539_05120	COG1136	(ABC) transporter
AL539_05140	COG0019	diaminopimelate decarboxylase activity
AL539_05145	COG4264	IucA IucC family
AL539_05170	COG4772	TonB-dependent receptor
AL539_05175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL539_05180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_05185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_05190	COG1120	ATPase activity
AL539_05195	COG0840	transmembrane signaling receptor activity
AL539_05200	COG0612	Peptidase, M16
AL539_05210	COG0739	heme binding
AL539_05225	COG2814	Major facilitator Superfamily
AL539_05235	COG1609	Transcriptional regulator
AL539_05240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL539_05265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL539_05270	COG1609	Transcriptional regulator
AL539_05320	COG1760	l-serine dehydratase
AL539_05330	COG4580	involved in the transport of maltose and maltodextrins
AL539_05350	COG2356	endonuclease I
AL539_05370	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL539_05375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL539_05380	COG1162	GTPase activity
AL539_05385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_05385	COG1263	PTS System
AL539_05390	COG1999	signal sequence binding
AL539_05405	COG2909	trisaccharide binding
AL539_05410	COG0058	SHG alpha-glucan phosphorylase activity
AL539_05415	COG1640	4-alpha-glucanotransferase
AL539_05420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL539_05425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL539_05430	COG0366	Alpha amylase catalytic
AL539_05445	COG3366	ferrous iron transmembrane transporter activity
AL539_05450	COG0700	Nucleoside recognition
AL539_05455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL539_05460	COG3339	Conserved Protein
AL539_05475	COG1301	dicarboxylic acid transport
AL539_05485	COG0583	DNA-binding transcription factor activity
AL539_05530	COG2095	MarC family integral membrane protein
AL539_05535	COG4667	esterase of the alpha-beta hydrolase superfamily
AL539_05540	COG3397	chitin binding
AL539_05545	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AL539_05550	COG0415	Belongs to the DNA photolyase family
AL539_05570	COG1686	Belongs to the peptidase S11 family
AL539_05595	COG0583	DNA-binding transcription factor activity
AL539_05600	COG4628	conserved protein (DUF2132)
AL539_05620	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL539_05625	COG0628	permease
AL539_05670	COG2814	Major facilitator Superfamily
AL539_05680	COG0454	-acetyltransferase
AL539_05690	COG0745	RESPONSE REGULATOR receiver
AL539_05695	COG2205	protein histidine kinase activity
AL539_05710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL539_05715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL539_05755	COG1360	Flagellar Motor Protein
AL539_05760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL539_05765	COG1191	sigma factor activity
AL539_05770	COG1580	Controls the rotational direction of flagella during chemotaxis
AL539_05785	COG1516	flagellar protein fliS
AL539_05790	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL539_05800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_05815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL539_05825	COG1987	bacterial-type flagellum assembly
AL539_05850	COG2204	response regulator
AL539_05865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL539_05925	COG0346	lactoylglutathione lyase activity
AL539_05950	COG0745	RESPONSE REGULATOR receiver
AL539_05975	COG3300	MHYT domain
AL539_05975	COG5001	Diguanylate cyclase
AL539_05980	COG0156	8-amino-7-oxononanoate synthase activity
AL539_05985	COG1063	alcohol dehydrogenase
AL539_06020	COG0668	transmembrane transport
AL539_06030	COG1304	FMN binding
AL539_06035	COG1620	l-lactate permease
AL539_06040	COG0583	DNA-binding transcription factor activity
AL539_06045	COG1505	serine-type exopeptidase activity
AL539_06050	COG4172	Belongs to the ABC transporter superfamily
AL539_06060	COG1067	ATP-dependent peptidase activity
AL539_06065	COG0840	transmembrane signaling receptor activity
AL539_06070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_06090	COG1247	-acetyltransferase
AL539_06095	COG0437	4 iron, 4 sulfur cluster binding
AL539_06100	COG0348	domain, Protein
AL539_06120	COG1122	ATPase activity
AL539_06125	COG4720	Psort location CytoplasmicMembrane, score
AL539_06130	COG1566	PFAM secretion protein HlyD family protein
AL539_06140	COG3706	GGDEF domain
AL539_06155	COG0813	purine-nucleoside phosphorylase activity
AL539_06160	COG3272	Protein of unknown function (DUF1722)
AL539_06165	COG0789	Transcriptional regulator
AL539_06170	COG0415	Belongs to the DNA photolyase family
AL539_06175	COG1376	ErfK ybiS ycfS ynhG family protein
AL539_06175	COG1388	LysM domain
AL539_06185	COG0513	Belongs to the DEAD box helicase family
AL539_06190	COG1770	oligopeptidase
AL539_06195	COG4771	TonB-dependent receptor
AL539_06220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL539_06225	COG0573	inorganic phosphate transmembrane transporter activity
AL539_06230	COG0581	inorganic phosphate transmembrane transporter activity
AL539_06235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL539_06250	COG2304	oxidoreductase activity
AL539_06255	COG2304	oxidoreductase activity
AL539_06270	COG0714	Associated with various cellular activities
AL539_06285	COG2197	response regulator
AL539_06320	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL539_06325	COG1120	ATPase activity
AL539_06335	COG1132	(ABC) transporter
AL539_06350	COG0569	domain protein
AL539_06355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_06360	COG0583	DNA-binding transcription factor activity
AL539_06380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_06385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_06395	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL539_06400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL539_06430	COG2084	Dehydrogenase
AL539_06435	COG0753	catalase activity
AL539_06445	COG2130	NADP-dependent
AL539_06450	COG1309	transcriptional regulator
AL539_06495	COG0489	protein tyrosine kinase activity
AL539_06495	COG3206	protein involved in exopolysaccharide biosynthesis
AL539_06510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL539_06515	COG3842	ATPase activity
AL539_06525	COG1175	transmembrane transport
AL539_06530	COG3833	ABC-type maltose transport systems, permease component
AL539_06560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL539_06565	COG4774	siderophore transport
AL539_06570	COG4607	ABC-type enterochelin transport system periplasmic component
AL539_06575	COG4605	iron ion homeostasis
AL539_06580	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_06590	COG2354	Protein conserved in bacteria
AL539_06595	COG0418	dihydroorotase activity
AL539_06605	COG0401	homolog of Blt101
AL539_06610	COG0633	Ferredoxin
AL539_06610	COG3217	Mosc domain protein beta barrel domain protein
AL539_06610	COG3217	Mosc domain protein beta barrel domain protein
AL539_06610	COG0633	Ferredoxin
AL539_06620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL539_06660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL539_06665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_06675	COG0848	biopolymer transport protein
AL539_06680	COG0811	peptide transport
AL539_06685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL539_06695	COG3721	Heme iron utilization protein
AL539_06700	COG0748	coenzyme F420 binding
AL539_06710	COG0784	Response regulator, receiver
AL539_06710	COG0835	chemotaxis
AL539_06715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL539_06720	COG0534	Mate efflux family protein
AL539_06725	COG0444	Belongs to the ABC transporter superfamily
AL539_06730	COG4608	Belongs to the ABC transporter superfamily
AL539_06735	COG0747	negative chemotaxis
AL539_06745	COG1349	DNA-binding transcription factor activity
AL539_06750	COG2084	Dehydrogenase
AL539_06755	COG3395	kinase activity
AL539_06760	COG0235	Class ii aldolase
AL539_06765	COG3622	Belongs to the hyi family
AL539_06770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL539_06775	COG2610	gluconate transmembrane transporter activity
AL539_06800	COG0583	DNA-binding transcription factor activity
AL539_06805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL539_06815	COG4934	collagen metabolic process
AL539_06825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL539_06830	COG0789	Transcriptional regulator
AL539_06835	COG0366	Alpha amylase catalytic
AL539_06855	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL539_06860	COG0589	response to stress
AL539_06865	COG0488	(ABC) transporter
AL539_06870	COG1505	serine-type exopeptidase activity
AL539_06880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_06890	COG2067	long-chain fatty acid transport protein
AL539_06900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_06925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_06945	COG3383	formate dehydrogenase (NAD+) activity
AL539_06955	COG0842	Transport permease protein
AL539_06960	COG1131	(ABC) transporter
AL539_06975	COG1881	PFAM PEBP family protein
AL539_06985	COG0798	PFAM Bile acid sodium symporter
AL539_07000	COG1733	regulation of RNA biosynthetic process
AL539_07030	COG4989	oxidoreductase activity
AL539_07055	COG0814	amino acid
AL539_07095	COG0739	heme binding
AL539_07100	COG5001	Diguanylate cyclase
AL539_07105	COG0583	DNA-binding transcription factor activity
AL539_07110	COG2814	Major facilitator Superfamily
AL539_07130	COG0697	spore germination
AL539_07145	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL539_07165	COG1280	lysine exporter protein (LysE YggA)
AL539_07175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL539_07180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL539_07190	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL539_07195	COG1845	cytochrome c oxidase, subunit III
AL539_07215	COG1612	heme a metabolic process
AL539_07225	COG0545	Peptidyl-prolyl cis-trans isomerase
AL539_07255	COG1278	Cold shock
AL539_07260	COG3036	rescue of stalled ribosome
AL539_07265	COG2199	diguanylate cyclase activity
AL539_07280	COG1132	(ABC) transporter
AL539_07290	COG1538	Outer membrane efflux protein
AL539_07295	COG2205	protein histidine kinase activity
AL539_07295	COG0784	Response regulator, receiver
AL539_07320	COG0840	transmembrane signaling receptor activity
AL539_07325	COG0783	Belongs to the Dps family
AL539_07335	COG2133	pyrroloquinoline quinone binding
AL539_07340	COG1454	alcohol dehydrogenase
AL539_07345	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL539_07365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL539_07370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL539_07375	COG3186	Phenylalanine-4-hydroxylase
AL539_07400	COG3530	Putative quorum-sensing-regulated virulence factor
AL539_07440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_07455	COG0732	type I restriction modification DNA specificity domain
AL539_07460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL539_07580	COG4628	conserved protein (DUF2132)
AL539_07590	COG0133	tryptophan synthase activity
AL539_07600	COG1278	Cold shock
AL539_07610	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL539_07620	COG0523	cobalamin synthesis protein
AL539_07625	COG0513	Belongs to the DEAD box helicase family
AL539_07645	COG2200	EAL domain
AL539_07650	COG1119	ATPase activity
AL539_07670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL539_07685	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL539_07690	COG0513	Belongs to the DEAD box helicase family
AL539_07705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL539_07715	COG1073	alpha beta
AL539_07720	COG1073	alpha beta
AL539_07735	COG0730	response to heat
AL539_07750	COG0735	belongs to the Fur family
AL539_07755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL539_07765	COG0523	cobalamin synthesis protein
AL539_07770	COG2988	succinylglutamate desuccinylase activity
AL539_07775	COG0739	heme binding
AL539_07785	COG0523	cobalamin synthesis protein
AL539_07795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL539_07805	COG2095	MarC family integral membrane protein
AL539_07835	COG1024	Enoyl-CoA hydratase
AL539_07840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL539_07845	COG1960	acyl-CoA dehydrogenase activity
AL539_07855	COG0183	Belongs to the thiolase family
AL539_07870	COG1024	Enoyl-CoA hydratase
AL539_07875	COG1024	Enoyl-CoA hydratase
AL539_07885	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_07890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL539_07895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL539_07900	COG1845	cytochrome c oxidase, subunit III
AL539_07905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL539_07910	COG0109	protoheme IX farnesyltransferase activity
AL539_07915	COG1902	pentaerythritol trinitrate reductase activity
AL539_07915	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL539_07930	COG1012	belongs to the aldehyde dehydrogenase family
AL539_07940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_07970	COG1126	abc transporter atp-binding protein
AL539_07975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_07980	COG4215	(ABC) transporter
AL539_07985	COG4160	amino acid transport
AL539_08050	COG0443	Heat shock 70 kDa protein
AL539_08055	COG2847	Copper chaperone PCu(A)C
AL539_08120	COG3706	GGDEF domain
AL539_08130	COG0814	amino acid
AL539_08140	COG0243	molybdopterin cofactor binding
AL539_08170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL539_08170	COG1116	anion transmembrane transporter activity
AL539_08185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL539_08190	COG1116	anion transmembrane transporter activity
AL539_08195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_08195	COG2146	nitrite reductase [NAD(P)H] activity
AL539_08245	COG0515	serine threonine protein kinase
AL539_08245	COG2815	serine threonine protein kinase
AL539_08275	COG0681	Belongs to the peptidase S26 family
AL539_08300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_08385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL539_08465	COG1620	l-lactate permease
AL539_08470	COG0247	lactate metabolic process
AL539_08475	COG1139	Iron-sulfur cluster binding protein
AL539_08480	COG1556	Lactate utilization protein
AL539_08485	COG0583	DNA-binding transcription factor activity
AL539_08555	COG1192	Involved in chromosome partitioning
AL539_08565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_08680	COG3209	COG3209 Rhs family protein
AL539_08690	COG3209	COG3209 Rhs family protein
AL539_08855	COG3423	Transcriptional regulator
AL539_08925	COG2433	Pfam Transposase IS66
AL539_08975	COG5564	TIM-barrel signal transduction protein
AL539_08980	COG5441	Belongs to the UPF0261 family
AL539_08990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL539_09010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL539_09015	COG0732	type I restriction modification DNA specificity domain
AL539_09025	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL539_09035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_09060	COG0629	single-stranded DNA binding
AL539_09075	COG0714	Associated with various cellular activities
AL539_09100	COG2003	Belongs to the UPF0758 family
AL539_09275	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL539_09370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL539_09430	COG0714	Associated with various cellular activities
AL539_09460	COG5433	transposase activity
AL539_09495	COG1294	oxidase, subunit
AL539_09500	COG1271	oxidase subunit
AL539_09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_09525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_09550	COG3568	Endonuclease Exonuclease Phosphatase
AL539_09705	COG0583	DNA-binding transcription factor activity
AL539_09715	COG0686	Belongs to the AlaDH PNT family
AL539_09725	COG1674	ftsk spoiiie
AL539_09735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL539_09755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL539_09780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL539_09800	COG0300	oxidoreductase activity
AL539_09815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL539_09825	COG2268	Band 7 protein
AL539_09835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL539_09840	COG2915	High frequency lysogenization protein hflD homolog
AL539_09855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_09865	COG1757	Na H antiporter
AL539_09875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL539_09885	COG0131	Imidazoleglycerol-phosphate dehydratase
AL539_09885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL539_09890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL539_09895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL539_09900	COG0107	imidazoleglycerol-phosphate synthase activity
AL539_09905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL539_09905	COG0140	phosphoribosyl-ATP diphosphatase activity
AL539_09910	COG3012	SEC-C Motif Domain Protein
AL539_09915	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL539_09920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_09925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL539_09930	COG0215	cysteine-tRNA ligase activity
AL539_09935	COG1435	thymidine kinase activity
AL539_09965	COG2116	formate transmembrane transporter activity
AL539_09975	COG0390	transport system, permease component
AL539_09980	COG4459	periplasmic nitrate reductase
AL539_09985	COG3005	denitrification pathway
AL539_09990	COG0243	molybdopterin cofactor binding
AL539_10005	COG1227	inorganic diphosphatase activity
AL539_10015	COG4172	Belongs to the ABC transporter superfamily
AL539_10025	COG4171	peptide transport system, permease
AL539_10030	COG4168	peptide transport system, permease
AL539_10040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL539_10045	COG1842	Phage shock protein A
AL539_10055	COG1983	PspC domain protein
AL539_10075	COG2818	Glycosylase
AL539_10080	COG5380	lipid catabolic process
AL539_10085	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL539_10090	COG0626	cystathionine gamma-synthase activity
AL539_10100	COG0733	neurotransmitter:sodium symporter activity
AL539_10105	COG0564	pseudouridine synthase activity
AL539_10115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL539_10120	COG1151	hydroxylamine reductase activity
AL539_10125	COG3604	Transcriptional regulator
AL539_10140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL539_10145	COG4136	ATPase activity
AL539_10150	COG4135	transport system, permease component
AL539_10155	COG4134	Bacterial extracellular solute-binding protein
AL539_10165	COG3313	Fe-S protein
AL539_10190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL539_10195	COG2205	protein histidine kinase activity
AL539_10200	COG0745	RESPONSE REGULATOR receiver
AL539_10210	COG1061	Type III restriction enzyme res subunit
AL539_10215	COG1187	pseudouridine synthase activity
AL539_10225	COG2814	Major facilitator Superfamily
AL539_10235	COG0702	epimerase
AL539_10240	COG0534	Mate efflux family protein
AL539_10260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL539_10270	COG1960	acyl-CoA dehydrogenase activity
AL539_10275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL539_10280	COG3273	potassium ion transport
AL539_10280	COG2985	domain, Protein
AL539_10285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL539_10295	COG1737	Transcriptional regulator
AL539_10300	COG0076	glutamate decarboxylase activity
AL539_10310	COG2431	L-lysine efflux transmembrane transporter activity
AL539_10330	COG3070	regulator of competence-specific genes
AL539_10345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_10345	COG4191	Histidine kinase
AL539_10355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL539_10365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL539_10370	COG4988	ABC transporter
AL539_10375	COG0492	ferredoxin-NADP+ reductase activity
AL539_10395	COG0745	RESPONSE REGULATOR receiver
AL539_10395	COG3706	GGDEF domain
AL539_10400	COG0471	metal ion transport
AL539_10405	COG2949	membrane
AL539_10410	COG0281	malic enzyme
AL539_10415	COG1643	Atp-dependent helicase
AL539_10430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL539_10465	COG0277	FAD linked oxidase domain protein
AL539_10465	COG0247	lactate metabolic process
AL539_10480	COG2986	histidine ammonia-lyase
AL539_10485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL539_10490	COG0010	Belongs to the arginase family
AL539_10495	COG1228	amidohydrolase
AL539_10515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL539_10525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL539_10535	COG0393	Putative heavy-metal-binding
AL539_10570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL539_10575	COG0072	phenylalanine-tRNA ligase activity
AL539_10575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL539_10585	COG0776	regulation of translation
AL539_10595	COG0500	methyltransferase
AL539_10600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL539_10605	COG0295	cytidine deaminase activity
AL539_10610	COG1346	cytolysis
AL539_10615	COG1380	Effector of murein hydrolase LrgA
AL539_10620	COG2925	Exonuclease
AL539_10630	COG0702	epimerase
AL539_10635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL539_10640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL539_10660	COG2988	succinylglutamate desuccinylase activity
AL539_10665	COG4139	cobalamin transport
AL539_10670	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL539_10690	COG0583	DNA-binding transcription factor activity
AL539_10700	COG1451	nucleotide metabolic process
AL539_10735	COG3938	Belongs to the proline racemase family
AL539_10750	COG2423	ornithine cyclodeaminase activity
AL539_10755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL539_10760	COG3842	ATPase activity
AL539_10765	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL539_10770	COG1177	transmembrane transport
AL539_10780	COG3291	Pkd domain containing protein
AL539_10795	COG0444	Belongs to the ABC transporter superfamily
AL539_10800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_10805	COG0601	transmembrane transport
AL539_10815	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL539_10825	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL539_10835	COG0625	glutathione transferase activity
AL539_11000	COG1757	Na H antiporter
AL539_11005	COG0174	glutamine synthetase
AL539_11015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL539_11020	COG1917	Cupin 2, conserved barrel domain protein
AL539_11020	COG1396	sequence-specific DNA binding
AL539_11025	COG1012	belongs to the aldehyde dehydrogenase family
AL539_11030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_11040	COG2957	Belongs to the agmatine deiminase family
AL539_11045	COG1012	belongs to the aldehyde dehydrogenase family
AL539_11050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL539_11055	COG2200	EAL domain
AL539_11065	COG1846	Transcriptional regulator
AL539_11070	COG2315	Protein conserved in bacteria
AL539_11110	COG3063	Type IV pilus biogenesis stability protein PilW
AL539_11115	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL539_11130	COG1560	Kdo2-lipid A biosynthetic process
AL539_11135	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL539_11140	COG1280	lysine exporter protein (LysE YggA)
AL539_11150	COG1115	amino acid carrier protein
AL539_11175	COG1368	sulfuric ester hydrolase activity
AL539_11180	COG2113	Glycine betaine
AL539_11185	COG4176	ABC-type proline glycine betaine transport system permease component
AL539_11190	COG4175	Glycine betaine
AL539_11205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_11210	COG0456	acetyltransferase
AL539_11215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL539_11220	COG0662	Cupin 2, conserved barrel domain protein
AL539_11225	COG0527	aspartate kinase activity
AL539_11230	COG3119	arylsulfatase activity
AL539_11245	COG0641	radical SAM
AL539_11260	COG3119	arylsulfatase activity
AL539_11285	COG1538	Outer membrane efflux protein
AL539_11300	COG1349	DNA-binding transcription factor activity
AL539_11305	COG0673	inositol 2-dehydrogenase activity
AL539_11310	COG4702	Belongs to the UPF0303 family
AL539_11315	COG3706	GGDEF domain
AL539_11315	COG0745	RESPONSE REGULATOR receiver
AL539_11335	COG0471	metal ion transport
AL539_11350	COG3300	MHYT domain
AL539_11350	COG5001	Diguanylate cyclase
AL539_11365	COG1328	CTP reductase activity
AL539_11370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL539_11380	COG0861	Integral membrane protein TerC family
AL539_11390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL539_11400	COG0814	amino acid
AL539_11415	COG1120	ATPase activity
AL539_11420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL539_11430	COG4774	siderophore transport
AL539_11440	COG1132	(ABC) transporter
AL539_11445	COG1132	(ABC) transporter
AL539_11460	COG0583	DNA-binding transcription factor activity
AL539_11485	COG0443	Heat shock 70 kDa protein
AL539_11490	COG0443	Heat shock 70 kDa protein
AL539_11535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL539_11540	COG1643	Atp-dependent helicase
AL539_11555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_11565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL539_11570	COG1215	transferase activity, transferring glycosyl groups
AL539_11575	COG0438	transferase activity, transferring glycosyl groups
AL539_11605	COG0438	transferase activity, transferring glycosyl groups
AL539_11615	COG2204	response regulator
AL539_11645	COG1793	dna ligase
AL539_11655	COG0534	Mate efflux family protein
AL539_11660	COG0307	riboflavin synthase, alpha
AL539_11680	COG3706	GGDEF domain
AL539_11690	COG0791	NLP P60 protein
AL539_11730	COG1940	carbohydrate kinase activity
AL539_11740	COG0303	'Molybdopterin
AL539_11745	COG0746	molybdenum cofactor guanylyltransferase activity
AL539_11750	COG3842	ATPase activity
AL539_11765	COG2204	response regulator
AL539_11770	COG4191	Histidine kinase
AL539_11780	COG0488	(ABC) transporter
AL539_11785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL539_11805	COG3381	protein complex oligomerization
AL539_11815	COG0243	molybdopterin cofactor binding
AL539_11815	COG3383	formate dehydrogenase (NAD+) activity
AL539_11820	COG0437	4 iron, 4 sulfur cluster binding
AL539_11955	COG0004	ammonium transporteR
AL539_11960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL539_11965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL539_11970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL539_11975	COG1177	transmembrane transport
AL539_11980	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL539_11985	COG3842	ATPase activity
AL539_12010	COG0589	response to stress
AL539_12015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_12030	COG2217	Heavy metal translocating P-type atpase
AL539_12040	COG2010	Cytochrome c
AL539_12055	COG3278	Belongs to the heme-copper respiratory oxidase family
AL539_12070	COG2205	protein histidine kinase activity
AL539_12070	COG0784	Response regulator, receiver
AL539_12100	COG3120	sequence-specific DNA binding
AL539_12105	COG1067	ATP-dependent peptidase activity
AL539_12110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL539_12135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL539_12135	COG0116	Belongs to the methyltransferase superfamily
AL539_12145	COG0167	dihydroorotate dehydrogenase activity
AL539_12150	COG2902	Dehydrogenase
AL539_12160	COG0308	aminopeptidase N
AL539_12175	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL539_12180	COG1956	GAF domain-containing protein
AL539_12185	COG1132	(ABC) transporter
AL539_12190	COG2995	paraquat-inducible protein a
AL539_12195	COG3008	intermembrane lipid transfer
AL539_12220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL539_12225	COG1666	GTP binding
AL539_12240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_12245	COG4597	amino acid ABC transporter
AL539_12250	COG0765	amino acid transport
AL539_12255	COG1126	abc transporter atp-binding protein
AL539_12260	COG0670	Belongs to the BI1 family
AL539_12270	COG2920	part of a sulfur-relay system
AL539_12275	COG1254	Belongs to the acylphosphatase family
AL539_12300	COG2885	chlorophyll binding
AL539_12340	COG2203	Gaf domain
AL539_12340	COG2199	diguanylate cyclase activity
AL539_12345	COG1414	Transcriptional regulator
AL539_12355	COG0656	L-ascorbic acid biosynthetic process
AL539_12360	COG0583	DNA-binding transcription factor activity
AL539_12370	COG0583	DNA-binding transcription factor activity
AL539_12375	COG2814	Major facilitator Superfamily
AL539_12395	COG1335	isochorismatase
AL539_12400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_12415	COG1410	methionine synthase
AL539_12415	COG0646	methionine synthase
AL539_12420	COG1126	abc transporter atp-binding protein
AL539_12425	COG0765	amino acid transport
AL539_12430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_12445	COG0583	DNA-binding transcription factor activity
AL539_12460	COG0583	DNA-binding transcription factor activity
AL539_12470	COG0583	DNA-binding transcription factor activity
AL539_12485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL539_12490	COG0602	queuosine metabolic process
AL539_12495	COG0561	phosphatase activity
AL539_12520	COG2828	Protein conserved in bacteria
AL539_12530	COG0372	Belongs to the citrate synthase family
AL539_12535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL539_12570	COG0730	response to heat
AL539_12595	COG0457	Tetratricopeptide repeat
AL539_12660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL539_12665	COG4790	Type iii secretion
AL539_12670	COG4794	Type iii secretion
AL539_12675	COG4791	protein targeting
AL539_12680	COG4792	protein secretion
AL539_12685	COG2207	Transcriptional regulator
AL539_12715	COG3177	Filamentation induced by cAMP protein fic
AL539_12735	COG4669	(LipO)protein
AL539_12805	COG1012	belongs to the aldehyde dehydrogenase family
AL539_12810	COG3284	Transcriptional regulator
AL539_12825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL539_12830	COG0363	glucosamine-6-phosphate deaminase activity
AL539_12835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL539_12840	COG2207	Transcriptional regulator
AL539_12850	COG4565	transcriptional regulatory protein
AL539_12855	COG3290	protein histidine kinase activity
AL539_12870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_12900	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL539_12910	COG2985	domain, Protein
AL539_12940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL539_12955	COG1280	lysine exporter protein (LysE YggA)
AL539_12960	COG1280	lysine exporter protein (LysE YggA)
AL539_12965	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL539_12985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL539_12990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_12995	COG0110	maltose O-acetyltransferase activity
AL539_13105	COG2824	Alkylphosphonate utilization operon protein PhnA
AL539_13200	COG2801	Transposase and inactivated derivatives
AL539_13645	COG2026	Addiction module toxin, RelE StbE family
AL539_13680	COG2026	Addiction module toxin, RelE StbE family
AL539_13690	COG2026	Addiction module toxin, RelE StbE family
AL539_13790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_13800	COG3768	UPF0283 membrane protein
AL539_13805	COG3106	COG3106 Predicted ATPase
AL539_13825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL539_13830	COG2205	protein histidine kinase activity
AL539_13830	COG0784	Response regulator, receiver
AL539_13840	COG0494	nUDIX hydrolase
AL539_13845	COG0814	amino acid
AL539_13850	COG1760	l-serine dehydratase
AL539_13855	COG2200	EAL domain
AL539_13865	COG0720	synthase
AL539_13870	COG0840	transmembrane signaling receptor activity
AL539_13875	COG0017	Asparaginyl-tRNA synthetase
AL539_13885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_13900	COG1448	Aminotransferase
AL539_13920	COG0840	transmembrane signaling receptor activity
AL539_13925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_13955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL539_13970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL539_13975	COG3108	Peptidase M15
AL539_13980	COG2989	Protein conserved in bacteria
AL539_14005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL539_14015	COG4235	cytochrome complex assembly
AL539_14015	COG3088	subunit of a heme lyase
AL539_14025	COG1138	Cytochrome C-type biogenesis protein
AL539_14030	COG3301	Polysulphide reductase, NrfD
AL539_14035	COG0437	4 iron, 4 sulfur cluster binding
AL539_14045	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL539_14065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL539_14075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL539_14080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL539_14105	COG0019	diaminopimelate decarboxylase activity
AL539_14145	COG0322	excinuclease ABC activity
AL539_14150	COG2197	response regulator
AL539_14155	COG0417	DNA replication proofreading
AL539_14175	COG1187	pseudouridine synthase activity
AL539_14185	COG0009	L-threonylcarbamoyladenylate synthase
AL539_14190	COG0613	PHP domain protein
AL539_14200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL539_14205	COG0512	Glutamine amidotransferase of anthranilate synthase
AL539_14215	COG0134	indole-3-glycerol-phosphate synthase activity
AL539_14215	COG0135	phosphoribosylanthranilate isomerase activity
AL539_14225	COG0159	tryptophan synthase activity
AL539_14230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_14235	COG0318	PFAM AMP-dependent synthetase and ligase
AL539_14245	COG1301	dicarboxylic acid transport
AL539_14265	COG2917	probably involved in intracellular septation
AL539_14270	COG1607	acyl-coa hydrolase
AL539_14275	COG2350	Protein conserved in bacteria
AL539_14285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL539_14290	COG0583	DNA-binding transcription factor activity
AL539_14305	COG5001	Diguanylate cyclase
AL539_14310	COG1032	radical SAM domain protein
AL539_14335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL539_14340	COG0463	Glycosyl transferase, family 2
AL539_14345	COG0745	RESPONSE REGULATOR receiver
AL539_14350	COG3850	Histidine kinase
AL539_14350	COG5002	protein histidine kinase activity
AL539_14380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL539_14400	COG0577	efflux transmembrane transporter activity
AL539_14400	COG1136	(ABC) transporter
AL539_14410	COG0577	efflux transmembrane transporter activity
AL539_14410	COG1136	(ABC) transporter
AL539_14420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_14440	COG3118	belongs to the thioredoxin family
AL539_14445	COG4232	protein-disulfide reductase activity
AL539_14480	COG2863	cytochrome
AL539_14485	COG3258	Cytochrome c
AL539_14490	COG2995	paraquat-inducible protein a
AL539_14495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL539_14495	COG3008	intermembrane lipid transfer
AL539_14515	COG4166	transmembrane transport
AL539_14525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL539_14530	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL539_14540	COG0539	negative regulation of cytoplasmic translation
AL539_14545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL539_14550	COG0616	signal peptide processing
AL539_14555	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_14570	COG0587	DNA-directed DNA polymerase activity
AL539_14575	COG0784	Response regulator, receiver
AL539_14575	COG0835	chemotaxis
AL539_14580	COG1940	carbohydrate kinase activity
AL539_14585	COG0469	pyruvate kinase activity
AL539_14590	COG4667	esterase of the alpha-beta hydrolase superfamily
AL539_14605	COG0733	neurotransmitter:sodium symporter activity
AL539_14615	COG1263	PTS System
AL539_14615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_14620	COG0084	hydrolase, TatD family'
AL539_14625	COG0470	DNA polymerase III
AL539_14630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL539_14635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL539_14665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL539_14670	COG0416	fatty acid biosynthetic process
AL539_14680	COG1399	metal-binding, possibly nucleic acid-binding protein
AL539_14685	COG0424	maF-like protein
AL539_14690	COG0564	pseudouridine synthase activity
AL539_14700	COG1530	ribonuclease E activity
AL539_14710	COG0659	secondary active sulfate transmembrane transporter activity
AL539_14715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL539_14720	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL539_14730	COG0572	uridine kinase
AL539_14735	COG0489	protein tyrosine kinase activity
AL539_14740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL539_14740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL539_14765	COG2186	Transcriptional regulator
AL539_14770	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL539_14775	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL539_14780	COG3318	Belongs to the UPF0149 family
AL539_14780	COG3012	SEC-C Motif Domain Protein
AL539_14785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL539_14790	COG3706	GGDEF domain
AL539_14795	COG0366	Alpha amylase catalytic
AL539_14800	COG1122	ATPase activity
AL539_14805	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL539_14815	COG3092	negative regulation of chromosome organization
AL539_14820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL539_14825	COG0280	phosphate acetyltransferase
AL539_14825	COG0857	belongs to the CobB CobQ family
AL539_14835	COG0435	Glutathione S-transferase
AL539_14845	COG0444	Belongs to the ABC transporter superfamily
AL539_14850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_14855	COG0601	transmembrane transport
AL539_14870	COG0314	molybdopterin synthase activity
AL539_14875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL539_14880	COG0315	cyclic pyranopterin monophosphate synthase activity
AL539_14885	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL539_14890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL539_14895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL539_14900	COG2198	Histidine kinase
AL539_14905	COG2204	response regulator
AL539_14910	COG0556	nucleotide-excision repair
AL539_14920	COG1882	Formate acetyltransferase
AL539_14925	COG4657	Part of a membrane complex involved in electron transport
AL539_14930	COG2878	Part of a membrane complex involved in electron transport
AL539_14935	COG4656	Part of a membrane complex involved in electron transport
AL539_14940	COG4658	electron transport chain
AL539_14945	COG4659	FMN binding
AL539_14950	COG4660	Part of a membrane complex involved in electron transport
AL539_14955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL539_14960	COG0346	lactoylglutathione lyase activity
AL539_14970	COG2885	chlorophyll binding
AL539_14980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL539_14985	COG2056	Na+-H+ antiporter family
AL539_15005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL539_15025	COG1454	alcohol dehydrogenase
AL539_15025	COG1012	belongs to the aldehyde dehydrogenase family
AL539_15030	COG2095	MarC family integral membrane protein
AL539_15035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_15040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL539_15045	COG1757	Na H antiporter
AL539_15060	COG3081	Nucleoid-associated protein
AL539_15065	COG3082	Protein of unknown function (DUF1414)
AL539_15070	COG3083	sulfuric ester hydrolase activity
AL539_15080	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL539_15095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL539_15100	COG0778	Nitroreductase
AL539_15110	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL539_15110	COG1902	pentaerythritol trinitrate reductase activity
AL539_15115	COG0616	signal peptide processing
AL539_15120	COG0252	asparaginase activity
AL539_15125	COG3139	Protein of unknown function (DUF1315)
AL539_15135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_15140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL539_15155	COG2226	methyltransferase
AL539_15175	COG1785	Belongs to the alkaline phosphatase family
AL539_15185	COG0346	lactoylglutathione lyase activity
AL539_15190	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL539_15195	COG0668	transmembrane transport
AL539_15200	COG2983	Belongs to the UPF0260 family
AL539_15205	COG2261	transglycosylase associated protein
AL539_15215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL539_15220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL539_15225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL539_15235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL539_15240	COG2832	Protein of unknown function (DUF454)
AL539_15250	COG0745	RESPONSE REGULATOR receiver
AL539_15255	COG0583	DNA-binding transcription factor activity
AL539_15260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL539_15265	COG1286	toxin biosynthetic process
AL539_15270	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL539_15275	COG0285	dihydrofolate synthase activity
AL539_15280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL539_15290	COG0101	tRNA pseudouridine synthase activity
AL539_15300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL539_15305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL539_15315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL539_15320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL539_15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_15325	COG0431	NADPH-dependent FMN reductase
AL539_15340	COG3101	peptidyl-lysine hydroxylation
AL539_15350	COG2860	membrane
AL539_15355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL539_15360	COG2890	protein-(glutamine-N5) methyltransferase activity
AL539_15365	COG2840	Smr protein MutS2
AL539_15370	COG2062	phosphohistidine phosphatase, SixA
AL539_15385	COG1024	Enoyl-CoA hydratase
AL539_15385	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL539_15390	COG0183	Belongs to the thiolase family
AL539_15415	COG2067	long-chain fatty acid transport protein
AL539_15445	COG5564	TIM-barrel signal transduction protein
AL539_15450	COG5441	Belongs to the UPF0261 family
AL539_15465	COG3088	subunit of a heme lyase
AL539_15465	COG4235	cytochrome complex assembly
AL539_15475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL539_15480	COG1138	Cytochrome C-type biogenesis protein
AL539_15485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL539_15490	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL539_15495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL539_15500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL539_15505	COG4133	protoheme IX ABC transporter activity
AL539_15515	COG0835	chemotaxis
AL539_15525	COG1192	Involved in chromosome partitioning
AL539_15530	COG2201	protein-glutamate methylesterase activity
AL539_15535	COG0643	Histidine kinase
AL539_15535	COG2198	Histidine kinase
AL539_15540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL539_15555	COG0455	bacterial-type flagellum organization
AL539_15575	COG1684	flagellar biosynthetic protein fliR
AL539_15580	COG1987	bacterial-type flagellum assembly
AL539_15635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL539_15645	COG1677	Flagellar hook-basal body complex protein FliE
AL539_15650	COG2204	response regulator
AL539_15655	COG4191	Histidine kinase
AL539_15660	COG2204	response regulator
AL539_15665	COG1516	flagellar protein fliS
AL539_15675	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL539_15680	COG1334	flagellar protein FlaG
AL539_15685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_15690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_15700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_15705	COG2837	iron assimilation
AL539_15730	COG1393	Belongs to the ArsC family
AL539_15735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL539_15755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL539_15765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL539_15780	COG4783	chaperone-mediated protein folding
AL539_15785	COG1393	Belongs to the ArsC family
AL539_15805	COG2233	PERMEase
AL539_15810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL539_15815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL539_15820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL539_15825	COG0121	glutamine amidotransferase
AL539_15830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL539_15835	COG1960	acyl-CoA dehydrogenase activity
AL539_15865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL539_15870	COG0328	RNA-DNA hybrid ribonuclease activity
AL539_15875	COG2226	methyltransferase
AL539_15880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL539_15885	COG1388	LysM domain
AL539_15885	COG0741	lytic transglycosylase activity
AL539_15895	COG3021	interspecies interaction between organisms
AL539_15900	COG0347	Belongs to the P(II) protein family
AL539_15915	COG0825	malonyl-CoA metabolic process
AL539_15920	COG0587	DNA-directed DNA polymerase activity
AL539_15930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_15935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_15945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_15950	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL539_15960	COG0750	zinc metalloprotease
AL539_15965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL539_15970	COG0575	Belongs to the CDS family
AL539_15975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL539_15980	COG0233	cytoplasmic translational termination
AL539_15985	COG0528	UMP kinase activity
AL539_15990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL539_15995	COG0052	Belongs to the universal ribosomal protein uS2 family
AL539_16000	COG0024	Methionine aminopeptidase
AL539_16005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL539_16015	COG0564	pseudouridine synthase activity
AL539_16020	COG3098	single-species biofilm formation
AL539_16055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL539_16060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL539_16085	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL539_16095	COG0254	rRNA binding
AL539_16100	COG1720	tRNA m6t6A37 methyltransferase activity
AL539_16105	COG0442	prolyl-tRNA aminoacylation
AL539_16125	COG0733	neurotransmitter:sodium symporter activity
AL539_16140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_16145	COG0514	ATP-dependent DNA helicase (RecQ)
AL539_16150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL539_16160	COG3706	GGDEF domain
AL539_16160	COG0745	RESPONSE REGULATOR receiver
AL539_16170	COG1477	protein flavinylation
AL539_16175	COG2871	sodium ion transport
AL539_16180	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_16185	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_16190	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_16195	COG1805	sodium ion transport
AL539_16200	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_16205	COG0271	Belongs to the BolA IbaG family
AL539_16210	COG2813	Specifically methylates the guanine in position
AL539_16215	COG3056	Lipoprotein
AL539_16235	COG1595	DNA-templated transcription, initiation
AL539_16255	COG3248	Nucleoside-binding outer membrane protein
AL539_16260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL539_16265	COG0693	protein deglycase activity
AL539_16270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL539_16275	COG3706	GGDEF domain
AL539_16280	COG2166	iron-sulfur cluster assembly
AL539_16285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL539_16290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL539_16305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL539_16305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL539_16325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL539_16330	COG1074	ATP-dependent DNA helicase activity
AL539_16335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL539_16355	COG3141	response to X-ray
AL539_16370	COG2171	N-acyltransferase activity
AL539_16375	COG0584	glycerophosphoryl diester phosphodiesterase
AL539_16380	COG2271	Major facilitator Superfamily
AL539_16390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL539_16395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL539_16400	COG1349	DNA-binding transcription factor activity
AL539_16405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL539_16410	COG0598	Magnesium transport protein CorA
AL539_16430	COG1609	Transcriptional regulator
AL539_16435	COG0583	DNA-binding transcription factor activity
AL539_16475	COG1022	Amp-dependent synthetase and ligase
AL539_16485	COG0583	DNA-binding transcription factor activity
AL539_16490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL539_16495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL539_16505	COG0560	Phosphoserine phosphatase
AL539_16515	COG0813	purine-nucleoside phosphorylase activity
AL539_16520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL539_16525	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL539_16530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL539_16535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL539_16540	COG0084	hydrolase, TatD family'
AL539_16570	COG3153	acetyltransferase
AL539_16600	COG0534	Mate efflux family protein
AL539_16615	COG1185	polyribonucleotide nucleotidyltransferase activity
AL539_16620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL539_16625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL539_16630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL539_16635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL539_16640	COG0195	Participates in both transcription termination and antitermination
AL539_16645	COG0779	Required for maturation of 30S ribosomal subunits
AL539_16660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL539_16670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL539_16675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL539_16680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL539_16685	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL539_16690	COG1534	Rna-binding protein
AL539_16695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_16700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_16705	COG2027	D-alanyl-D-alanine carboxypeptidase
AL539_16715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL539_16720	COG0739	heme binding
AL539_16745	COG0628	permease
AL539_16760	COG0747	negative chemotaxis
AL539_16770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_16775	COG0444	Belongs to the ABC transporter superfamily
AL539_16780	COG4608	Belongs to the ABC transporter superfamily
AL539_16790	COG2971	BadF BadG BcrA BcrD
AL539_16805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL539_16810	COG3842	ATPase activity
AL539_16820	COG1840	ABC-type Fe3 transport system, periplasmic component
AL539_16825	COG0004	ammonium transporteR
AL539_16835	COG3112	Uncharacterised protein family (UPF0231)
AL539_16840	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL539_16845	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL539_16850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL539_16855	COG1643	Atp-dependent helicase
AL539_16860	COG1489	DNA binding
AL539_16865	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL539_16870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL539_16880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL539_16885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL539_16890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL539_16895	COG1560	Kdo2-lipid A biosynthetic process
AL539_16905	COG0842	Transport permease protein
AL539_16910	COG1131	(ABC) transporter
AL539_16915	COG0659	secondary active sulfate transmembrane transporter activity
AL539_16920	COG0288	reversible hydration of carbon dioxide
AL539_16935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_16940	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL539_16945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL539_16950	COG2186	Transcriptional regulator
AL539_16960	COG0157	Belongs to the NadC ModD family
AL539_16970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL539_16975	COG1459	type II secretion system
AL539_16985	COG0237	dephospho-CoA kinase activity
AL539_16990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL539_16995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL539_17010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL539_17015	COG0228	four-way junction DNA binding
AL539_17020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL539_17025	COG4137	Cytochrome C assembly protein
AL539_17030	COG4536	flavin adenine dinucleotide binding
AL539_17035	COG1854	S-ribosylhomocysteine lyase activity
AL539_17050	COG0612	Peptidase, M16
AL539_17055	COG1238	metal cluster binding
AL539_17065	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL539_17070	COG5016	pyruvate
AL539_17070	COG0511	ligase activity, forming carbon-carbon bonds
AL539_17135	COG0527	aspartate kinase activity
AL539_17140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL539_17145	COG2137	regulation of response to DNA damage stimulus
AL539_17150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL539_17155	COG1546	Belongs to the CinA family
AL539_17160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL539_17165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL539_17175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL539_17180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL539_17190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL539_17195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL539_17200	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL539_17205	COG0148	phosphopyruvate hydratase activity
AL539_17210	COG0504	CTP synthase activity
AL539_17215	COG3956	TIGRFAM MazG family protein
AL539_17220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL539_17230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL539_17245	COG0736	holo-[acyl-carrier-protein] synthase activity
AL539_17250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL539_17255	COG1381	Involved in DNA repair and RecF pathway recombination
AL539_17260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL539_17270	COG0681	Belongs to the peptidase S26 family
AL539_17275	COG0481	GTPase activity
AL539_17280	COG3086	response to oxidative stress
AL539_17295	COG1595	DNA-templated transcription, initiation
AL539_17305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL539_17315	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL539_17320	COG0354	folic acid binding
AL539_17335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL539_17340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL539_17345	COG3079	Belongs to the UPF0149 family
AL539_17355	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL539_17365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL539_17370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL539_17375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL539_17385	COG0583	DNA-binding transcription factor activity
AL539_17400	COG0668	transmembrane transport
AL539_17405	COG0191	fructose-bisphosphate aldolase activity
AL539_17420	COG4771	TonB-dependent receptor
AL539_17425	COG0583	DNA-binding transcription factor activity
AL539_17430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL539_17440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL539_17455	COG2356	endonuclease I
AL539_17460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL539_17465	COG0189	ligase activity
AL539_17470	COG1678	Uncharacterized ACR, COG1678
AL539_17475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL539_17490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL539_17495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL539_17500	COG0762	integral membrane protein
AL539_17505	COG1872	DUF167
AL539_17515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL539_17520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL539_17525	COG2066	Belongs to the glutaminase family
AL539_17535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL539_17540	COG1194	a g-specific adenine glycosylase
AL539_17560	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL539_17570	COG0154	amidase activity
AL539_17580	COG1074	ATP-dependent DNA helicase activity
AL539_17675	COG4974	Belongs to the 'phage' integrase family
AL539_17685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL539_17695	COG1194	a g-specific adenine glycosylase
AL539_17715	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL539_17725	COG0154	amidase activity
AL539_17820	COG4974	Belongs to the 'phage' integrase family
AL539_17830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL539_17845	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL539_17890	COG0840	transmembrane signaling receptor activity
AL539_17970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL539_17980	COG3394	polysaccharide catabolic process
AL539_17985	COG1486	melibiose metabolic process
AL539_17990	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL539_17995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL539_18005	COG0726	polysaccharide deacetylase
AL539_18015	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_18020	COG4325	translation initiation factor activity
AL539_18030	COG0795	lipopolysaccharide-transporting ATPase activity
AL539_18035	COG0795	lipopolysaccharide-transporting ATPase activity
AL539_18040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL539_18045	COG2927	DNA polymerase III (CHI subunit)
AL539_18050	COG0525	valine-tRNA ligase activity
AL539_18060	COG0456	acetyltransferase
AL539_18090	COG0540	Belongs to the ATCase OTCase family
AL539_18095	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL539_18100	COG0251	oxidation-reduction process
AL539_18105	COG0204	Acyl-transferase
AL539_18110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL539_18115	COG5007	Belongs to the BolA IbaG family
AL539_18125	COG2854	intermembrane phospholipid transfer
AL539_18130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL539_18135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL539_18140	COG1127	ABC transporter
AL539_18150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL539_18150	COG0517	IMP dehydrogenase activity
AL539_18160	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL539_18165	COG1137	ATPase activity
AL539_18175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL539_18180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_18185	COG1660	Displays ATPase and GTPase activities
AL539_18190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_18195	COG2239	Acts as a magnesium transporter
AL539_18200	COG0312	modulator of DNA gyrase
AL539_18205	COG3028	Belongs to the UPF0307 family
AL539_18210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL539_18215	COG0564	pseudouridine synthase activity
AL539_18225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL539_18230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL539_18235	COG0312	modulator of DNA gyrase
AL539_18240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL539_18245	COG3164	Protein of unknown function
AL539_18250	COG1530	ribonuclease E activity
AL539_18255	COG0424	maF-like protein
AL539_18260	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL539_18265	COG1792	Involved in formation and maintenance of cell shape
AL539_18270	COG1077	Cell shape determining protein MreB Mrl
AL539_18290	COG2200	EAL domain
AL539_18290	COG2199	diguanylate cyclase activity
AL539_18295	COG0629	single-stranded DNA binding
AL539_18310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL539_18320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL539_18330	COG0527	aspartate kinase activity
AL539_18335	COG0646	methionine synthase
AL539_18335	COG1410	methionine synthase
AL539_18400	COG0175	sulfate reduction
AL539_18405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_18410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL539_18430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL539_18435	COG0735	belongs to the Fur family
AL539_18445	COG0166	Belongs to the GPI family
AL539_18450	COG0432	Pfam Uncharacterised protein family UPF0047
AL539_18455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL539_18460	COG0305	Participates in initiation and elongation during chromosome replication
AL539_18480	COG2965	DNA replication, synthesis of RNA primer
AL539_18485	COG0360	Binds together with S18 to 16S ribosomal RNA
AL539_18490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL539_18495	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL539_18505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL539_18510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL539_18540	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL539_18550	COG0678	peroxiredoxin activity
AL539_18550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL539_18555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_18565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL539_18565	COG0165	Argininosuccinate lyase
AL539_18570	COG0137	argininosuccinate synthase activity
AL539_18580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL539_18590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL539_18600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL539_18605	COG0527	aspartate kinase activity
AL539_18605	COG0460	homoserine dehydrogenase
AL539_18610	COG0626	cystathionine gamma-synthase activity
AL539_18620	COG0281	malic enzyme
AL539_18630	COG2906	2 iron, 2 sulfur cluster binding
AL539_18635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL539_18640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL539_18660	COG2923	Belongs to the DsrF TusC family
AL539_18665	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL539_18670	COG2964	Protein conserved in bacteria
AL539_18675	COG0545	Peptidyl-prolyl cis-trans isomerase
AL539_18690	COG1446	asparaginase
AL539_18700	COG1047	Peptidyl-prolyl cis-trans
AL539_18715	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL539_18720	COG0488	(ABC) transporter
AL539_18730	COG0429	hydrolase of the alpha beta-hydrolase fold
AL539_18740	COG3954	Phosphoribulokinase
AL539_18745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_18765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL539_18770	COG0512	Glutamine amidotransferase of anthranilate synthase
AL539_18775	COG1846	Transcriptional regulator
AL539_18780	COG0697	spore germination
AL539_18790	COG1473	amidohydrolase
AL539_18795	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL539_18800	COG0583	DNA-binding transcription factor activity
AL539_18815	COG0180	Tryptophanyl-tRNA synthetase
AL539_18820	COG0546	phosphoglycolate phosphatase activity
AL539_18825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL539_18830	COG0557	exoribonuclease II activity
AL539_18835	COG1959	2 iron, 2 sulfur cluster binding
AL539_18840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL539_18840	COG1017	nitric oxide dioxygenase activity
AL539_18845	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL539_18855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL539_18860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL539_18865	COG0330	HflC and HflK could
AL539_18870	COG0330	HflC and HflK could
AL539_18875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL539_18885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL539_18890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL539_18900	COG0802	atpase or kinase
AL539_18910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL539_18975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL539_18980	COG1162	GTPase activity
AL539_18985	COG0688	phosphatidylethanolamine metabolic process
AL539_18990	COG0471	metal ion transport
AL539_18990	COG3273	potassium ion transport
AL539_19000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL539_19005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_19010	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL539_19015	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL539_19020	COG1045	serine acetyltransferase
AL539_19025	COG4942	peptidase
AL539_19045	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL539_19050	COG1053	succinate dehydrogenase
AL539_19055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL539_19060	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL539_19065	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL539_19080	COG1509	lysine 2,3-aminomutase activity
AL539_19085	COG1285	pathogenesis
AL539_19095	COG0459	protein refolding
AL539_19100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL539_19105	COG0534	Mate efflux family protein
AL539_19110	COG0205	6-phosphofructokinase activity
AL539_19120	COG3678	ATP-independent chaperone mediated protein folding
AL539_19125	COG0745	RESPONSE REGULATOR receiver
AL539_19130	COG2205	protein histidine kinase activity
AL539_19140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL539_19145	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL539_19150	COG1027	Aspartate ammonia-lyase
AL539_19155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL539_19160	COG4232	protein-disulfide reductase activity
AL539_19170	COG3263	regulation of cellular component size
AL539_19180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL539_19205	COG2814	Major facilitator Superfamily
AL539_19220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL539_19225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL539_19230	COG0511	ligase activity, forming carbon-carbon bonds
AL539_19235	COG0439	Biotin carboxylase
AL539_19245	COG2264	protein methyltransferase activity
AL539_19250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL539_19255	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL539_19265	COG0488	(ABC) transporter
AL539_19330	COG1982	Orn Lys Arg decarboxylase major
AL539_19335	COG0531	amino acid
AL539_19345	COG3710	Transcriptional regulator
AL539_19350	COG0789	Transcriptional regulator
AL539_19365	COG0151	Belongs to the GarS family
AL539_19380	COG1253	flavin adenine dinucleotide binding
AL539_19385	COG3068	Protein conserved in bacteria
AL539_19395	COG1573	uracil-dna glycosylase
AL539_19400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL539_19405	COG2816	NAD+ diphosphatase activity
AL539_19410	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL539_19415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL539_19420	COG0085	RNA polymerase activity
AL539_19425	COG0222	ribosome binding
AL539_19430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL539_19445	COG0250	Participates in transcription elongation, termination and antitermination
AL539_19450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL539_19460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL539_19490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL539_19490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL539_19495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL539_19505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL539_19585	COG4206	TonB-dependent receptor
AL539_19605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_19610	COG0534	Mate efflux family protein
AL539_19615	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL539_19625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL539_19635	COG2937	Belongs to the GPAT DAPAT family
AL539_19640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL539_19645	COG3161	chorismate lyase activity
AL539_19650	COG1580	Controls the rotational direction of flagella during chemotaxis
AL539_19655	COG0705	Rhomboid family
AL539_19660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_19675	COG2177	Part of the ABC transporter FtsEX involved in
AL539_19680	COG2884	Cell division ATP-binding protein ftsE
AL539_19685	COG0552	protein localization to endoplasmic reticulum
AL539_19690	COG0742	ribosomal rna small subunit methyltransferase
AL539_19700	COG2095	MarC family integral membrane protein
AL539_19745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL539_19750	COG0640	Transcriptional regulator
AL539_19755	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL539_19760	COG1280	lysine exporter protein (LysE YggA)
AL539_19765	COG2267	carboxylic ester hydrolase activity
AL539_19770	COG0561	phosphatase activity
AL539_19790	COG2200	EAL domain
AL539_19790	COG2199	diguanylate cyclase activity
AL539_19790	COG3287	FIST C domain
AL539_19795	COG1011	Hydrolase
AL539_19800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL539_19815	COG0019	diaminopimelate decarboxylase activity
AL539_19825	COG1965	Belongs to the frataxin family
AL539_19830	COG3072	Adenylate cyclase
AL539_19835	COG0181	hydroxymethylbilane synthase activity
AL539_19840	COG1587	Uroporphyrinogen-III synthase
AL539_19845	COG2959	enzyme of heme biosynthesis
AL539_19850	COG3071	HemY protein
AL539_19895	COG0633	Ferredoxin
AL539_19900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL539_19910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL539_19915	COG3118	belongs to the thioredoxin family
AL539_19920	COG0513	Belongs to the DEAD box helicase family
AL539_19925	COG0248	Ppx GppA phosphatase
AL539_19935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL539_19945	COG0514	ATP-dependent DNA helicase (RecQ)
AL539_19950	COG2962	Rard protein
AL539_19960	COG1280	lysine exporter protein (LysE YggA)
AL539_19965	COG0405	Gamma-glutamyltransferase
AL539_19975	COG0210	DNA helicase
AL539_19985	COG3220	belongs to the UPF0276 family
AL539_20015	COG0006	proline dipeptidase activity
AL539_20015	COG0006	proline dipeptidase activity
AL539_20030	COG2104	thiamine diphosphate biosynthetic process
AL539_20035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL539_20055	COG2132	Multicopper oxidase
AL539_20185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL539_20200	COG0408	coproporphyrinogen oxidase activity
AL539_20205	COG0009	L-threonylcarbamoyladenylate synthase
AL539_20210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL539_20215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL539_20220	COG0551	DNA topoisomerase type I activity
AL539_20225	COG2922	Belongs to the Smg family
AL539_20230	COG0758	DNA mediated transformation
AL539_20240	COG0242	peptide deformylase activity
AL539_20245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL539_20250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL539_20250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL539_20255	COG0569	domain protein
AL539_20260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_20270	COG1272	protein, Hemolysin III
AL539_20275	COG4326	sporulation control protein
AL539_20285	COG3084	Protein conserved in bacteria
AL539_20295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL539_20300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_20305	COG0204	Acyl-transferase
AL539_20315	COG0606	chelatase, subunit chli
AL539_20325	COG3978	acetolactate synthase activity
AL539_20330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL539_20335	COG0129	dihydroxy-acid dehydratase activity
AL539_20345	COG0583	DNA-binding transcription factor activity
AL539_20350	COG2814	Major facilitator Superfamily
AL539_20360	COG0765	amino acid transport
AL539_20370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL539_20375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL539_20380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL539_20385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL539_20390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL539_20395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL539_20405	COG0356	it plays a direct role in the translocation of protons across the membrane
AL539_20410	COG3312	ion transport
AL539_20415	COG1475	DNA binding
AL539_20420	COG1192	Involved in chromosome partitioning
AL539_20425	COG0357	Ribosomal RNA small subunit methyltransferase G
AL539_20430	COG0445	tRNA wobble uridine modification
AL539_20440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL539_20450	COG0706	membrane insertase activity
AL539_20455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL539_20460	COG0594	ribonuclease P activity
AL539_20470	COG1126	abc transporter atp-binding protein
AL539_20490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL539_20495	COG0592	DNA-directed DNA polymerase activity
AL539_20505	COG0187	DNA topoisomerase II activity
AL539_20525	COG0071	Belongs to the small heat shock protein (HSP20) family
AL539_20530	COG3977	Valine--pyruvate aminotransferase
AL539_20535	COG0366	Alpha amylase catalytic
AL539_20550	COG2119	membrane
AL539_20560	COG0425	Belongs to the sulfur carrier protein TusA family
AL539_20575	COG0604	alcohol dehydrogenase
AL539_20580	COG0183	Belongs to the thiolase family
AL539_20590	COG1739	Uncharacterized protein family UPF0029
AL539_20595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_20640	COG0583	DNA-binding transcription factor activity
AL539_20645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL539_20650	COG2960	long-chain fatty acid transporting porin activity
AL539_20655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_20660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_20715	COG4172	Belongs to the ABC transporter superfamily
AL539_20720	COG4166	transmembrane transport
AL539_20730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_20745	COG1609	Transcriptional regulator
AL539_20750	COG0583	DNA-binding transcription factor activity
AL539_20760	COG2076	Multidrug Resistance protein
AL539_20765	COG0129	dihydroxy-acid dehydratase activity
AL539_20770	COG3265	gluconokinase activity
AL539_20775	COG2610	gluconate transmembrane transporter activity
AL539_20780	COG0800	Aldolase
AL539_20785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL539_20790	COG0583	DNA-binding transcription factor activity
AL539_20795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_20800	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL539_20810	COG1522	sequence-specific DNA binding
AL539_20815	COG5002	protein histidine kinase activity
AL539_20815	COG5001	Diguanylate cyclase
AL539_20830	COG0697	spore germination
AL539_20835	COG0589	response to stress
AL539_20840	COG1528	Iron-storage protein
AL539_20850	COG2081	HI0933 family
AL539_20880	COG1597	lipid kinase activity
AL539_20910	COG0628	permease
AL539_20925	COG1322	Protein conserved in bacteria
AL539_20930	COG2226	methyltransferase
AL539_20935	COG3165	ubiquinone biosynthetic process from chorismate
AL539_20940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL539_20955	COG0805	protein transport
AL539_20970	COG0084	hydrolase, TatD family'
AL539_20985	COG0456	acetyltransferase
AL539_20995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL539_20995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL539_21000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL539_21030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL539_21035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL539_21045	COG2204	response regulator
AL539_21050	COG3852	Histidine kinase
AL539_21060	COG0174	glutamine synthetase
AL539_21070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL539_21080	COG1295	ribonuclease BN
AL539_21085	COG1490	D-aminoacyl-tRNA deacylase activity
AL539_21090	COG0456	acetyltransferase
AL539_21100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL539_21105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL539_21110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL539_21115	COG3031	protein transport across the cell outer membrane
AL539_21125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL539_21130	COG1459	type II secretion system
AL539_21135	COG2165	general secretion pathway protein
AL539_21140	COG2165	general secretion pathway protein
AL539_21145	COG2165	general secretion pathway protein
AL539_21150	COG4795	General secretion pathway protein
AL539_21155	COG3156	type II secretion system protein K
AL539_21160	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL539_21165	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL539_21175	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL539_21180	COG0494	nUDIX hydrolase
AL539_21190	COG1040	competence protein
AL539_21205	COG2183	response to ionizing radiation
AL539_21215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_21225	COG0745	RESPONSE REGULATOR receiver
AL539_21235	COG2233	PERMEase
AL539_21240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL539_21245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL539_21250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL539_21255	COG1758	RNA polymerase activity
AL539_21260	COG0194	GDP metabolic process
AL539_21280	COG0848	biopolymer transport protein
AL539_21285	COG0811	peptide transport
AL539_21310	COG4174	ABC transporter (Permease)
AL539_21315	COG4239	(ABC) transporter, permease
AL539_21320	COG0747	negative chemotaxis
AL539_21325	COG0444	Belongs to the ABC transporter superfamily
AL539_21330	COG4608	Belongs to the ABC transporter superfamily
AL539_21340	COG1561	YicC-like family, N-terminal region
AL539_21350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL539_21360	COG1560	Kdo2-lipid A biosynthetic process
AL539_21365	COG1309	transcriptional regulator
AL539_21370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL539_21385	COG2003	Belongs to the UPF0758 family
AL539_21430	COG0859	PFAM glycosyl transferase family 9
AL539_21435	COG0438	transferase activity, transferring glycosyl groups
AL539_21440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL539_21445	COG3642	lipopolysaccharide core region biosynthetic process
AL539_21490	COG1519	Transferase
AL539_21495	COG0859	PFAM glycosyl transferase family 9
AL539_21500	COG1560	Kdo2-lipid A biosynthetic process
AL539_21510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_21565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL539_21590	COG1215	transferase activity, transferring glycosyl groups
AL539_21600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL539_21605	COG0110	maltose O-acetyltransferase activity
AL539_21610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL539_21625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL539_21635	COG0149	triose-phosphate isomerase activity
AL539_21660	COG1494	fructose-1,6-bisphosphatase
AL539_21670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL539_21675	COG1575	Belongs to the MenA family. Type 1 subfamily
AL539_21705	COG2003	Belongs to the UPF0758 family
AL539_21715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL539_21720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL539_21730	COG1609	Transcriptional regulator
AL539_21735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL539_21745	COG0254	rRNA binding
AL539_21755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL539_21760	COG0088	Forms part of the polypeptide exit tunnel
AL539_21770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL539_21775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL539_21780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL539_21785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL539_21795	COG0255	Belongs to the universal ribosomal protein uL29 family
AL539_21800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL539_21810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL539_21815	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL539_21825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL539_21830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL539_21845	COG1841	ribosomal large subunit assembly
AL539_21855	COG0201	protein transport
AL539_21865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL539_21870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL539_21880	COG0202	RNA polymerase activity
AL539_21885	COG0203	ribosomal protein L17
AL539_21895	COG0545	Peptidyl-prolyl cis-trans isomerase
AL539_21905	COG2153	protein acetylation
AL539_21910	COG0513	Belongs to the DEAD box helicase family
AL539_21925	COG1648	precorrin-2 dehydrogenase activity
AL539_21925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL539_21930	COG0175	sulfate reduction
AL539_21935	COG2895	sulfate adenylyltransferase (ATP) activity
AL539_21940	COG0471	metal ion transport
AL539_21940	COG3273	potassium ion transport
AL539_21945	COG0529	Catalyzes the synthesis of activated sulfate
AL539_21965	COG4181	ATPase activity
AL539_21980	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL539_21990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_21995	COG0729	surface antigen
AL539_22000	COG2911	Protein conserved in bacteria
AL539_22005	COG2105	PFAM AIG2 family protein
AL539_22025	COG0840	transmembrane signaling receptor activity
AL539_22060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL539_22065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL539_22075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL539_22080	COG0163	prenyltransferase activity
AL539_22085	COG4143	(ABC) transporter
AL539_22090	COG1178	ABC-type Fe3 transport system permease component
AL539_22095	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL539_22100	COG0583	DNA-binding transcription factor activity
AL539_22105	COG1902	pentaerythritol trinitrate reductase activity
AL539_22150	COG0142	geranyltranstransferase activity
AL539_22155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL539_22165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL539_22170	COG2966	Psort location CytoplasmicMembrane, score
AL539_22185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL539_22190	COG2967	ApaG domain
AL539_22195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL539_22200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL539_22205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL539_22210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL539_22215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL539_22235	COG0473	3-isopropylmalate dehydrogenase activity
AL539_22240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL539_22265	COG0583	DNA-binding transcription factor activity
AL539_22270	COG1022	Amp-dependent synthetase and ligase
AL539_22275	COG0028	Belongs to the TPP enzyme family
AL539_22280	COG0440	acetolactate synthase activity
AL539_22285	COG3706	GGDEF domain
AL539_22295	COG0469	pyruvate kinase activity
AL539_22300	COG1349	DNA-binding transcription factor activity
AL539_22305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL539_22340	COG0732	type I restriction modification DNA specificity domain
AL539_22365	COG2376	Dihydroxyacetone kinase
AL539_22370	COG1461	Dihydroxyacetone kinase
AL539_22385	COG3722	fumarate hydratase activity
AL539_22395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_22395	COG2213	PTS system mannitol-specific
AL539_22435	COG1278	Cold shock
AL539_22450	COG1278	Cold shock
AL539_22460	COG3550	peptidyl-serine autophosphorylation
AL539_22490	COG0210	DNA helicase
AL539_22510	COG3550	peptidyl-serine autophosphorylation
AL539_22525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL539_22530	COG0358	DNA primase activity
AL539_22535	COG1610	YqeY-like protein
AL539_22540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL539_22545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL539_22550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL539_22555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL539_22560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL539_22565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL539_22570	COG1968	undecaprenyl-diphosphatase activity
AL539_22580	COG3267	Type II secretory pathway component ExeA
AL539_22580	COG3409	Peptidoglycan-binding domain 1 protein
AL539_22590	COG0405	Gamma-glutamyltransferase
AL539_22595	COG4991	sh3 domain protein
AL539_22600	COG0306	phosphate transporter
AL539_22605	COG1392	Phosphate transport regulator
AL539_22610	COG3025	triphosphatase activity
AL539_22625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL539_22630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL539_22630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL539_22635	COG1538	Outer membrane efflux protein
AL539_22640	COG0494	nUDIX hydrolase
AL539_22645	COG3151	Protein conserved in bacteria
AL539_22655	COG3150	esterase
AL539_22660	COG0187	DNA topoisomerase II activity
AL539_22665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL539_22670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL539_22680	COG3105	Protein conserved in bacteria
AL539_22690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL539_22705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL539_22710	COG0723	plastoquinol--plastocyanin reductase activity
AL539_22715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL539_22720	COG2857	Cytochrome c1
AL539_22725	COG0625	glutathione transferase activity
AL539_22730	COG2969	positive regulation of protein catabolic process
AL539_22735	COG2823	Periplasmic or secreted lipoprotein
AL539_22740	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL539_22755	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL539_22775	COG3116	cell division
AL539_22780	COG0768	penicillin binding
AL539_22785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL539_22790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL539_22795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL539_22800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL539_22805	COG0772	Belongs to the SEDS family
AL539_22820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL539_22825	COG0849	cell division
AL539_22830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL539_22835	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL539_22845	COG0653	protein targeting
AL539_22850	COG0494	nUDIX hydrolase
AL539_22860	COG0505	Belongs to the CarA family
AL539_22865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL539_22880	COG0730	response to heat
AL539_22885	COG0583	DNA-binding transcription factor activity
AL539_22890	COG2860	membrane
AL539_22905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL539_22915	COG0493	'glutamate synthase
AL539_22920	COG0067	glutamate synthase
AL539_22920	COG0069	glutamate synthase activity
AL539_22920	COG0070	glutamate synthase
AL539_22930	COG0067	glutamate synthase
AL539_22930	COG0070	glutamate synthase
AL539_22930	COG0069	glutamate synthase activity
AL539_22935	COG1242	4 iron, 4 sulfur cluster binding
AL539_22940	COG3706	GGDEF domain
AL539_22940	COG4251	negative regulation of phosphorylation
AL539_22940	COG5001	Diguanylate cyclase
AL539_22940	COG2203	Gaf domain
AL539_22945	COG0784	Response regulator, receiver
AL539_22945	COG2198	Histidine kinase
AL539_22945	COG5002	protein histidine kinase activity
AL539_22955	COG0745	RESPONSE REGULATOR receiver
AL539_22970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL539_22990	COG0083	homoserine kinase activity
AL539_22995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL539_23005	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL539_23010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL539_23020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL539_23035	COG1115	amino acid carrier protein
AL539_23040	COG3022	response to hydroperoxide
AL539_23045	COG0513	Belongs to the DEAD box helicase family
AL539_23050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL539_23060	COG0716	FMN binding
AL539_23070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_23075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL539_23090	COG2204	response regulator
AL539_23100	COG0667	Aldo Keto reductase
AL539_23125	COG0730	response to heat
AL539_23135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL539_23145	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL539_23150	COG0583	DNA-binding transcription factor activity
AL539_23155	COG0640	Transcriptional regulator
AL539_23160	COG0268	Binds directly to 16S ribosomal RNA
AL539_23165	COG0728	peptidoglycan biosynthetic process
AL539_23170	COG0196	riboflavin kinase activity
AL539_23185	COG1047	Peptidyl-prolyl cis-trans
AL539_23190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL539_23200	COG3279	Response regulator of the LytR AlgR family
AL539_23205	COG3275	phosphorelay sensor kinase activity
AL539_23210	COG1966	Carbon starvation protein
AL539_23230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL539_23235	COG1472	Belongs to the glycosyl hydrolase 3 family
AL539_23240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL539_23245	COG0287	Prephenate dehydrogenase
AL539_23245	COG1605	Chorismate mutase
AL539_23250	COG0739	heme binding
AL539_23260	COG0488	(ABC) transporter
AL539_23270	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL539_23275	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL539_23280	COG0077	Prephenate dehydratase
AL539_23280	COG1605	Chorismate mutase
AL539_23285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL539_23295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_23300	COG0564	pseudouridine synthase activity
AL539_23310	COG0542	response to heat
AL539_23375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL539_23385	COG2974	May be involved in recombination
AL539_23395	COG0745	RESPONSE REGULATOR receiver
AL539_23400	COG5002	protein histidine kinase activity
AL539_23410	COG0248	Ppx GppA phosphatase
AL539_23415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL539_23420	COG0573	inorganic phosphate transmembrane transporter activity
AL539_23425	COG0581	inorganic phosphate transmembrane transporter activity
AL539_23430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL539_23435	COG0704	Plays a role in the regulation of phosphate uptake
AL539_23445	COG3142	Participates in the control of copper homeostasis
AL539_23450	COG0450	alkyl hydroperoxide reductase
AL539_23455	COG0583	DNA-binding transcription factor activity
AL539_23460	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL539_23470	COG0517	IMP dehydrogenase activity
AL539_23480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL539_23490	COG1862	Preprotein translocase
AL539_23495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_23500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_23515	COG0483	inositol monophosphate 1-phosphatase activity
AL539_23520	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL539_23530	COG1104	cysteine desulfurase activity
AL539_23535	COG0822	iron-sulfur transferase activity
AL539_23550	COG0443	Heat shock 70 kDa protein
AL539_23555	COG0633	Ferredoxin
AL539_23560	COG2975	iron-sulfur cluster assembly
AL539_23570	COG0105	UTP biosynthetic process
AL539_23585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL539_23590	COG0124	histidyl-tRNA synthetase
AL539_23595	COG2976	Protein conserved in bacteria
AL539_23600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_23605	COG1160	GTP binding
AL539_23625	COG0517	IMP dehydrogenase activity
AL539_23625	COG0516	GMP reductase activity
AL539_23630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL539_23630	COG0519	Catalyzes the synthesis of GMP from XMP
AL539_23635	COG1757	Na H antiporter
AL539_23645	COG1584	GPR1 FUN34 yaaH family protein
AL539_23650	COG1115	amino acid carrier protein
AL539_23665	COG2873	o-acetylhomoserine
AL539_23670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL539_23690	COG3153	acetyltransferase
AL539_23690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL539_23695	COG0583	DNA-binding transcription factor activity
AL539_23740	COG3287	FIST C domain
AL539_23740	COG2199	diguanylate cyclase activity
AL539_23740	COG2200	EAL domain
AL539_23745	COG3300	MHYT domain
AL539_23745	COG5001	Diguanylate cyclase
AL539_23770	COG2801	Transposase and inactivated derivatives
AL539_23775	COG3706	GGDEF domain
AL539_23795	COG4974	Belongs to the 'phage' integrase family
AL539_23815	COG3550	peptidyl-serine autophosphorylation
AL539_23885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_23890	COG0732	type I restriction modification DNA specificity domain
AL539_23930	COG0582	viral genome integration into host DNA
AL539_23940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL539_23945	COG2867	negative regulation of translational initiation
AL539_23950	COG2914	Belongs to the UPF0125 (RnfH) family
AL539_23955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_23965	COG0497	DNA recombination
AL539_23975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL539_23980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL539_23985	COG1301	dicarboxylic acid transport
AL539_23995	COG0484	heat shock protein binding
AL539_24025	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL539_24030	COG0590	tRNA wobble adenosine to inosine editing
AL539_24040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL539_24045	COG0047	phosphoribosylformylglycinamidine synthase activity
AL539_24045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL539_24060	COG1629	transport
AL539_24075	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL539_24080	COG2252	PERMEase
AL539_24085	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL539_24100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL539_24105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL539_24110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL539_24115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL539_24115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL539_24140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL539_24145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL539_24155	COG0142	geranyltranstransferase activity
AL539_24160	COG1722	exodeoxyribonuclease VII activity
AL539_24165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL539_24175	COG0301	tRNA thio-modification
AL539_24175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_24180	COG0583	DNA-binding transcription factor activity
AL539_24190	COG2363	Small membrane protein
AL539_24200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL539_24205	COG1611	Belongs to the LOG family
AL539_24210	COG0745	RESPONSE REGULATOR receiver
AL539_24210	COG3706	GGDEF domain
AL539_24220	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL539_24220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL539_24230	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL539_24235	COG1464	Belongs to the NlpA lipoprotein family
AL539_24240	COG2011	ABC-type metal ion transport system permease component
AL539_24245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL539_24250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL539_24260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_24260	COG1263	PTS System
AL539_24265	COG0366	Alpha amylase catalytic
AL539_24280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL539_24285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL539_24290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL539_24295	COG0321	lipoyl(octanoyl) transferase activity
AL539_24305	COG1686	Belongs to the peptidase S11 family
AL539_24310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL539_24315	COG0772	Belongs to the SEDS family
AL539_24320	COG0768	penicillin binding
AL539_24325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL539_24330	COG0799	negative regulation of ribosome biogenesis
AL539_24335	COG1466	dna polymerase III delta subunit
AL539_24340	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL539_24345	COG0495	leucyl-tRNA aminoacylation
AL539_24350	COG2888	peptidyl-tyrosine sulfation
AL539_24355	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL539_24360	COG4535	Mg2 and Co2 transporter CorC
AL539_24365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL539_24370	COG1702	phosphate starvation-inducible protein PhoH
AL539_24375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL539_24385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL539_24495	COG0012	GTP binding
AL539_24500	COG0193	aminoacyl-tRNA hydrolase activity
AL539_24505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL539_24510	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL539_24515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL539_24520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL539_24530	COG2890	protein-(glutamine-N5) methyltransferase activity
AL539_24535	COG3094	Invasion gene expression up-regulator, SirB
AL539_24540	COG2912	Transglutaminase-like superfamily
AL539_24545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL539_24550	COG0737	Belongs to the 5'-nucleotidase family
AL539_24555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL539_24560	COG1187	pseudouridine synthase activity
AL539_24565	COG2840	Smr protein MutS2
AL539_24605	COG2608	mercury ion transmembrane transporter activity
AL539_24605	COG2217	Heavy metal translocating P-type atpase
AL539_24620	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL539_24675	COG0784	Response regulator, receiver
AL539_24675	COG0835	chemotaxis
AL539_24680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL539_24685	COG1815	bacterial-type flagellum-dependent cell motility
AL539_24690	COG1558	bacterial-type flagellum-dependent cell motility
AL539_24695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL539_24700	COG1749	Flagellar hook protein flgE
AL539_24705	COG4787	bacterial-type flagellum-dependent cell motility
AL539_24710	COG4786	Flagellar basal body rod
AL539_24715	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL539_24720	COG1706	bacterial-type flagellum-dependent cell motility
AL539_24725	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL539_24725	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL539_24735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_24740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_24750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_24755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_24760	COG2190	(PTS) system
AL539_24765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL539_24770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_24780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL539_24785	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL539_24790	COG3115	cell septum assembly
AL539_24795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL539_24815	COG0330	HflC and HflK could
AL539_24820	COG3118	belongs to the thioredoxin family
AL539_24830	COG0300	oxidoreductase activity
AL539_24835	COG1090	epimerase
AL539_24865	COG0622	Phosphoesterase
AL539_24885	COG3710	Transcriptional regulator
AL539_24890	COG0326	Molecular chaperone. Has ATPase activity
AL539_24900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL539_24905	COG3104	oligopeptide transport
AL539_24910	COG0250	Participates in transcription elongation, termination and antitermination
AL539_24915	COG0367	asparagine synthase
AL539_24920	COG4651	solute:proton antiporter activity
AL539_24920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL539_24925	COG1940	carbohydrate kinase activity
AL539_24925	COG1846	Transcriptional regulator
AL539_24930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL539_24940	COG2190	(PTS) system
AL539_24940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_24940	COG1263	PTS System
AL539_24945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL539_24950	COG0735	belongs to the Fur family
AL539_24960	COG0716	FMN binding
AL539_24970	COG0596	Alpha beta hydrolase
AL539_24975	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL539_24980	COG0033	Phosphoglucomutase
AL539_24990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL539_25000	COG2009	succinate dehydrogenase
AL539_25005	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL539_25010	COG1053	succinate dehydrogenase
AL539_25015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL539_25020	COG0567	Dehydrogenase, E1 component
AL539_25025	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL539_25030	COG0045	succinate-CoA ligase (ADP-forming) activity
AL539_25040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL539_25045	COG1121	(ABC) transporter
AL539_25050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL539_25060	COG1918	ferrous iron import across plasma membrane
AL539_25085	COG0018	arginyl-trna synthetase
AL539_25095	COG3102	Protein conserved in bacteria
AL539_25100	COG0788	formyltetrahydrofolate deformylase activity
AL539_25105	COG1199	ATP-dependent helicase activity
AL539_25110	COG1214	PFAM Peptidase M22, glycoprotease
AL539_25125	COG2267	carboxylic ester hydrolase activity
AL539_25130	COG0318	PFAM AMP-dependent synthetase and ligase
AL539_25135	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL539_25145	COG2894	cell division
AL539_25150	COG0850	regulation of cytokinetic process
AL539_25155	COG3100	YcgL domain-containing protein
AL539_25160	COG2951	lytic endotransglycosylase activity
AL539_25170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL539_25175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL539_25190	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_25195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL539_25200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL539_25225	COG2986	histidine ammonia-lyase
AL539_25230	COG1216	Glycosyl transferase, family 2
AL539_25235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL539_25250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL539_25255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL539_25290	COG0513	Belongs to the DEAD box helicase family
AL539_25295	COG0569	domain protein
AL539_25300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_25315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL539_25320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL539_25325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL539_25330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL539_25355	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL539_25365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL539_25370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL539_25375	COG0776	regulation of translation
AL539_25380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL539_25385	COG1555	photosystem II stabilization
AL539_25400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL539_25405	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL539_25410	COG0436	Aminotransferase
AL539_25415	COG1169	isochorismate synthase
AL539_25420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL539_25430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL539_25435	COG1441	menaquinone biosynthetic process
AL539_25450	COG2855	membrane
AL539_25455	COG0477	Major facilitator Superfamily
AL539_25505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_25510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_25525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL539_25530	COG1522	sequence-specific DNA binding
AL539_25540	COG1946	Acyl-CoA thioesterase
AL539_25545	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL539_25560	COG3706	GGDEF domain
AL539_25570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL539_25575	COG0517	IMP dehydrogenase activity
AL539_25575	COG0516	GMP reductase activity
AL539_25600	COG0537	adenosine 5'-monophosphoramidase activity
AL539_25625	COG3150	esterase
AL539_25630	COG1252	NADH dehydrogenase
AL539_25645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL539_25655	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL539_25660	COG1136	(ABC) transporter
AL539_25665	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL539_25675	COG0658	competence protein
AL539_25675	COG2333	competence protein COMEC
AL539_25680	COG1132	(ABC) transporter
AL539_25700	COG2719	SpoVR family
AL539_25705	COG2718	Belongs to the UPF0229 family
AL539_25710	COG2766	serine protein kinase
AL539_25720	COG3013	Belongs to the UPF0304 family
AL539_25730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL539_25740	COG1882	Formate acetyltransferase
AL539_25770	COG4215	(ABC) transporter
AL539_25785	COG0708	Exodeoxyribonuclease III
AL539_25795	COG3923	Primosomal replication protein n
AL539_25800	COG0730	response to heat
AL539_25805	COG1199	ATP-dependent helicase activity
AL539_25810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_25815	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL539_25820	COG1187	pseudouridine synthase activity
AL539_25830	COG1278	Cold shock
AL539_25835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL539_25840	COG0542	response to heat
AL539_25845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL539_25850	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL539_25855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL539_25875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL539_25880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL539_25885	COG0297	glycogen (starch) synthase activity
AL539_25905	COG3070	regulator of competence-specific genes
AL539_25910	COG1609	Transcriptional regulator
AL539_25915	COG3381	protein complex oligomerization
AL539_25920	COG0745	RESPONSE REGULATOR receiver
AL539_25925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL539_25930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL539_25935	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL539_25940	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL539_25945	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL539_25965	COG0189	ligase activity
AL539_25965	COG4067	protein conserved in archaea
AL539_25975	COG0500	methyltransferase
AL539_25985	COG1801	Protein of unknown function DUF72
AL539_25995	COG0217	transcriptional regulatory protein
AL539_26000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL539_26005	COG0632	four-way junction helicase activity
AL539_26010	COG2255	four-way junction helicase activity
AL539_26015	COG1271	oxidase subunit
AL539_26020	COG1294	oxidase, subunit
AL539_26025	COG4890	Cyd operon protein YbgT
AL539_26035	COG0824	Thioesterase
AL539_26040	COG0811	peptide transport
AL539_26055	COG0823	Involved in the tonB-independent uptake of proteins
AL539_26060	COG2885	chlorophyll binding
AL539_26065	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL539_26070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL539_26080	COG3766	membrane
AL539_26090	COG0754	glutathionylspermidine amidase activity