locus-tag class description AL539_00010 ENOG4106VK6 Flagellar motor protein AL539_00025 ENOG4108ZF3 Phosphatase AL539_00070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL539_00095 ENOG4107RFY SbcCD D subunit AL539_00100 ENOG4105EYH Exonuclease AL539_00110 ENOG4105QNF Outer membrane lipoprotein AL539_00120 ENOG4105CSX c4-dicarboxylate anaerobic carrier AL539_00130 ENOG4105C5W Aldolase AL539_00140 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) AL539_00145 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AL539_00160 ENOG4105CC0 LysR family Transcriptional regulator AL539_00165 ENOG4105CXG d-lactate dehydrogenase AL539_00180 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL539_00185 ENOG4108NVR Methyl-accepting chemotaxis AL539_00235 ENOG4105DEN Luciferase family AL539_00240 ENOG4105BZU Histidine kinase AL539_00250 ENOG4105BZU Histidine kinase AL539_00260 ENOG4105NXH GreA GreB family elongation factor AL539_00265 ENOG4107QZF nitrite reductase NADPH large subunit AL539_00270 ENOG4105WZK nitrite reductase NADPH small subunit AL539_00275 ENOG4105TMB Formate nitrite transporter AL539_00280 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL539_00295 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL539_00320 ENOG4105KNA -acetyltransferase AL539_00325 ENOG4105VXR cytoplasmic protein AL539_00330 ENOG4108ISG Major Facilitator AL539_00335 ENOG4105K63 Thioredoxin AL539_00340 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL539_00360 ENOG4105EIP mannose-6-phosphate isomerase AL539_00365 ENOG4105CXY transporter AL539_00370 ENOG4105BZU Histidine kinase AL539_00375 ENOG4108KX4 response regulator AL539_00380 ENOG4105CXY transporter AL539_00385 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL539_00390 ENOG4105C5Q Transcriptional regulator AL539_00400 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AL539_00415 ENOG4107TIF Phenazine biosynthesis protein, PhzF family AL539_00455 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AL539_00460 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AL539_00465 ENOG4105UQX Mate efflux family protein AL539_00470 ENOG4108K01 transcriptional regulator AL539_00475 ENOG4105CGF Aromatic amino acid aminotransferase AL539_00480 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL539_00490 ENOG4105WXI Bacterial OB fold (BOF) protein AL539_00495 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AL539_00500 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AL539_00505 ENOG4105E0C molybdate abc transporter AL539_00510 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AL539_00525 ENOG4105BZU Histidine kinase AL539_00555 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL539_00560 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL539_00590 ENOG4108M6U Universal stress protein A AL539_00600 ENOG4105EJC lysr family transcriptional regulator AL539_00620 ENOG4108ZJT translation initiation factor, Sui1 AL539_00630 ENOG4105CPF Cell wall formation (By similarity) AL539_00640 ENOG4105CD5 CoA-binding domain protein AL539_00645 ENOG4105CWB LysR family transcriptional Regulator AL539_00660 ENOG4105CMR udp-glucose 4-epimerase AL539_00665 ENOG4105BZU Histidine kinase AL539_00670 ENOG4105E7W lamb ycsf family protein AL539_00675 ENOG4105P4J Allophanate hydrolase, subunit 1 AL539_00680 ENOG4107R7A Allophanate hydrolase subunit 2 AL539_00690 ENOG4105CV6 ABC transporter, permease AL539_00695 ENOG4108I0Y (ABC) transporter AL539_00705 ENOG4105RKW reductase (By AL539_00710 ENOG4105BZU Histidine kinase AL539_00745 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AL539_00755 ENOG4105KA0 thioesterase Superfamily protein AL539_00770 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL539_00775 ENOG4108M0H Extracellular lipase AL539_00795 ENOG4105DU1 integral membrane protein, terc AL539_00800 ENOG4105CGH 5'-nucleotidase AL539_00805 ENOG4105CPB ATP-dependent endonuclease of the OLD family AL539_00810 ENOG4108UQ5 membrane protein YcdZ AL539_00815 ENOG4105DUM transcriptional regulator, lysR family AL539_00820 ENOG4105TMB Formate nitrite transporter AL539_00825 ENOG4108YYC ycei family AL539_00830 ENOG4105DS1 cytochrome b561 AL539_00850 ENOG4105C1J atp-dependent rna helicase AL539_00855 ENOG4108ZYK Acyl carrier protein phosphodiesterase AL539_00865 ENOG4108N3W hemolysin secretion protein AL539_00875 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL539_00890 ENOG4107RE1 Inosine-guanosine kinase AL539_00895 ENOG4105CKU formyltetrahydrofolate synthetase AL539_00900 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL539_00915 ENOG4105CF7 AraC family transcriptional regulator AL539_00920 ENOG4108I6A alcohol dehydrogenase AL539_00930 ENOG4105CDA abc transporter atp-binding protein AL539_00935 ENOG4105E5Q amino acid AbC transporter AL539_00940 ENOG4106TNF Periplasmic binding protein AL539_00945 ENOG4105DRP amino acid AbC transporter AL539_00950 ENOG4108NJZ Sensory box GGDEF EAL domain protein AL539_00965 ENOG4107B7Y DNA-binding transcriptional regulator FruR AL539_00970 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AL539_00975 ENOG4105DE4 1-phosphofructokinase AL539_00980 ENOG4105DM4 PTS System AL539_01010 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AL539_01020 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL539_01025 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AL539_01030 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AL539_01035 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AL539_01045 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AL539_01050 ENOG4105EJC lysr family transcriptional regulator AL539_01055 ENOG4108IPJ Membrane AL539_01060 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AL539_01090 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AL539_01140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL539_01175 ENOG4105CJW magnesium transporter AL539_01195 ENOG4108UYE Lactoylglutathione lyase AL539_01200 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL539_01210 ENOG4105EXC Acyl-transferase AL539_01225 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AL539_01230 ENOG4105CBC glutamate synthase AL539_01240 ENOG4107RGH Aldehyde dehydrogenase AL539_01255 ENOG4108I0N Transporter, RarD family, DMT superfamily protein AL539_01280 ENOG4105FR1 rard protein AL539_01290 ENOG4108VAU general secretion pathway protein G AL539_01295 ENOG4107R88 Chemotaxis protein (CheV) AL539_01315 ENOG4105BZU Histidine kinase AL539_01320 ENOG4105WH1 Two component transcriptional regulator luxr family AL539_01325 ENOG4105BZU Histidine kinase AL539_01330 ENOG4105BZU Histidine kinase AL539_01335 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AL539_01340 ENOG4107KBT 8-Amino-7-oxononanoate synthase AL539_01345 ENOG4108MGY Histidine kinase AL539_01365 ENOG4105CEE C4-dicarboxylate transporter AL539_01380 ENOG4105F2V VRR-NUC domain-containing protein AL539_01390 ENOG4108YDI single-species biofilm formation on inanimate substrate AL539_01395 ENOG4107TE5 Lipid kinase AL539_01400 ENOG41064T2 transcriptional regulator, lysR family AL539_01405 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL539_01435 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL539_01440 ENOG4105C4X radical SAM domain protein AL539_01445 ENOG41061MV Arylsulfatase AL539_01455 ENOG4105ENH Sulfatase AL539_01460 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL539_01475 ENOG4105BZU Histidine kinase AL539_01480 ENOG4108SV3 Tmao reductase system periplasmic protein tort AL539_01485 ENOG4108Z5K methylglyoxal synthase AL539_01490 ENOG41088T4 Helicase IV AL539_01495 ENOG4105EM2 membrane AL539_01540 ENOG4108Z6Z Transcriptional regulator AL539_01545 ENOG4108IPW abc transporter atp-binding protein AL539_01550 ENOG4105CM4 permease protein AL539_01555 ENOG4105DHS permease protein AL539_01570 ENOG4108I5U Uridine phosphorylase AL539_01575 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AL539_01585 ENOG4105ETE Transcriptional regulator (LacI family AL539_01590 ENOG4108RVA ribokinase AL539_01595 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AL539_01600 ENOG4105CNN ABC, transporter AL539_01605 ENOG4105C2J ABC transporter AL539_01610 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AL539_01615 ENOG4108K0B C-di-gmp phosphodiesterase AL539_01670 ENOG4105D82 Glutamate dehydrogenase AL539_01680 ENOG4105BZU Histidine kinase AL539_01685 ENOG4105CA0 peroxidase AL539_01695 ENOG4107QX8 SPFH domain, Band 7 family protein AL539_01705 ENOG4108RCM Nitroreductase AL539_01710 ENOG4108IJ7 Glycine betaine AL539_01715 ENOG4108HQS Glycine betaine AL539_01725 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AL539_01730 ENOG4105C26 Dehydrogenase AL539_01735 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AL539_01740 ENOG4105BZU Histidine kinase AL539_01750 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL539_01760 ENOG4105E39 Enoyl-CoA hydratase AL539_01765 ENOG4105C1G acyl-Coa dehydrogenase AL539_01770 ENOG4105C26 Dehydrogenase AL539_01775 ENOG4105CHU acetyl-coa acetyltransferase AL539_01785 ENOG4105C1G acyl-Coa dehydrogenase AL539_01790 ENOG4107QX3 carboxylase AL539_01795 ENOG4108IPT Naphthoate synthase AL539_01805 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL539_01815 ENOG4105EGS Mechanosensitive ion channel AL539_01825 ENOG4108UW5 maltose o-acetyltransferase AL539_01830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL539_01835 ENOG4105C4M (Ubiquinol oxidase) subunit I AL539_01840 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL539_01855 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AL539_01865 ENOG4107FQX Alpha-acetolactate decarboxylase AL539_01870 ENOG4105C7K acetolactate synthase AL539_01880 ENOG4105C94 Transporter AL539_01910 ENOG4105FQ6 thiopurine methyltransferase AL539_01915 ENOG4105DZS Phenylacetate-CoA ligase AL539_01920 ENOG4108IV0 ABC, transporter AL539_01940 ENOG4108IQE Amp-dependent synthetase and ligase AL539_01945 ENOG4105C0Z ABC transporter AL539_01955 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL539_01960 ENOG4105BZJ Electron transfer flavoprotein AL539_01965 ENOG4105C10 Electron transfer flavoprotein AL539_01970 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL539_01975 ENOG4105CI1 PTS System AL539_01980 ENOG4105F8D glycoside hydrolase family 4 AL539_01985 ENOG4105FDP GntR family transcriptional regulator AL539_01990 ENOG4105KJM monovalent cation h antiporter subunit g AL539_01995 ENOG41080TA Multiple resistance and ph regulation protein f AL539_02000 ENOG4105SC1 monovalent cation H antiporter subunit E AL539_02005 ENOG4108JPZ Monovalent cation H antiporter subunit D AL539_02010 ENOG4108ZE9 Monovalent cation H antiporter subunit C AL539_02015 ENOG4105D65 subunit l AL539_02025 ENOG4105Q9Y Universal stress protein AL539_02030 ENOG4105EMU Dehydrogenase AL539_02035 ENOG4105HEI LysR family (Transcriptional regulator AL539_02045 ENOG4105C2C drug resistance transporter, Bcr CflA AL539_02055 ENOG4105NVB glycoside hydrolase, family 19 AL539_02100 ENOG4105EW9 transcriptional regulator AsnC family AL539_02135 ENOG4105D9P serine threonine protein kinase AL539_02160 ENOG4105CS6 Rhs element vgr protein AL539_02165 ENOG4108WC9 type VI secretion system effector, hcp1 family AL539_02170 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL539_02175 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_02200 ENOG4105DR5 peptidase AL539_02225 ENOG4105DM4 PTS System AL539_02230 ENOG4108YRF PTS System AL539_02240 ENOG4106R3P AraC family transcriptional regulator AL539_02245 ENOG4105DM4 PTS System AL539_02250 ENOG4105EIP mannose-6-phosphate isomerase AL539_02260 ENOG4105DM4 PTS System AL539_02265 ENOG4105CWX Alpha-1,2-mannosidase AL539_02270 ENOG4105CWX Alpha-1,2-mannosidase AL539_02280 ENOG4105CWX Alpha-1,2-mannosidase AL539_02285 ENOG4105CWX Alpha-1,2-mannosidase AL539_02310 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL539_02315 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AL539_02325 ENOG4108UNF response regulator AL539_02330 ENOG4107RGM aldo keto reductase AL539_02345 ENOG4105CMQ Chloride channel AL539_02355 ENOG4105EUJ GTP cyclohydrolase i AL539_02360 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL539_02365 ENOG4105D06 uba thif-type nad fad binding protein AL539_02380 ENOG4105KHC sulfurtransferase AL539_02400 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL539_02405 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL539_02415 ENOG4105DXI Major Facilitator superfamily AL539_02420 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL539_02430 ENOG4105UYK outer membrane protein a AL539_02435 ENOG4107VXZ Hydrolase AL539_02440 ENOG4108YZN class I peptide chain release factor AL539_02445 ENOG4108N3W hemolysin secretion protein AL539_02460 ENOG4107YWA deoxycytidylate deaminase AL539_02465 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL539_02480 ENOG4105WH1 Two component transcriptional regulator luxr family AL539_02485 ENOG4105BZU Histidine kinase AL539_02500 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL539_02520 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AL539_02530 ENOG4105CHU acetyl-coa acetyltransferase AL539_02550 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL539_02555 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL539_02585 ENOG4105EW9 transcriptional regulator AsnC family AL539_02605 ENOG4105J12 Multidrug resistance protein mdtN AL539_02610 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AL539_02615 ENOG4105BZU Histidine kinase AL539_02620 ENOG4108QGH periplasmic AL539_02630 ENOG41082IR Excinuclease ABC C subunit domain protein AL539_02635 ENOG4108YXG UPF0502 protein AL539_02645 ENOG41090HJ UPF0265 protein AL539_02655 ENOG4105BZU Histidine kinase AL539_02695 ENOG4105DVH amino acid AL539_02710 ENOG4105E0F Histidine kinase AL539_02715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL539_02745 ENOG4105EFX secretion protein, HlyD family AL539_02750 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL539_02755 ENOG4105CJW magnesium transporter AL539_02760 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin AL539_02765 ENOG4105DZC cytosine deaminase AL539_02770 ENOG4105EST Metal Dependent Phosphohydrolase AL539_02785 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL539_02795 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AL539_02815 ENOG4108Z33 Thiol disulfide Interchange Protein AL539_02830 ENOG4107EXC regulatoR AL539_02835 ENOG4105E0F Histidine kinase AL539_02845 ENOG41080IJ Diacylglycerol kinase AL539_02850 ENOG4105DIJ Phosphoethanolamine transferase AL539_02855 ENOG4105EP9 oxidoreductase AL539_02870 ENOG4108NRW Phospholipase, patatin family AL539_02875 ENOG4105EUB pirin domain protein AL539_02880 ENOG4105VEQ Cold shock protein AL539_02895 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL539_02900 ENOG4105EHV domain protein AL539_02910 ENOG4105DZ1 carboxypeptidase AL539_02920 ENOG4105CYM Glutathione S-transferase AL539_02930 ENOG4108HKT sucrose-6-phosphate hydrolase AL539_02935 ENOG4105D7K pfkb domain protein AL539_02940 ENOG4105C5Y PTS System AL539_02965 ENOG4105CHR reductase AL539_02980 ENOG4108P3C AL539_02995 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL539_03000 ENOG4105HEI LysR family (Transcriptional regulator AL539_03005 ENOG410874W AraC family transcriptional regulator AL539_03010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL539_03040 ENOG4105C1J atp-dependent rna helicase AL539_03050 ENOG4107RSM transcriptional regulator AL539_03065 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL539_03070 ENOG4105CPQ Dehydrogenase AL539_03080 ENOG4105CHR reductase AL539_03095 ENOG4105ENR peptidase, M24 AL539_03100 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase AL539_03105 ENOG4108RYR transcriptional regulator AsnC family AL539_03110 ENOG4105C26 Dehydrogenase AL539_03115 ENOG4105C8Y Acetylornithine aminotransferase AL539_03120 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AL539_03140 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL539_03145 ENOG4105HDK L-asparaginase AL539_03150 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AL539_03165 ENOG4105WH1 Two component transcriptional regulator luxr family AL539_03170 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL539_03175 ENOG4107RUE extracellular solute-binding protein family 1 AL539_03225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL539_03245 ENOG4105BZS acriflavin resistance protein AL539_03275 ENOG4107RZC phospholipase d AL539_03300 ENOG4108Z4X TRANSCRIPTIONal AL539_03315 ENOG4105RQF LysR family Transcriptional regulator AL539_03325 ENOG4107S8C mandelate racemase muconate lactonizing AL539_03335 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL539_03360 ENOG4105VYW UPF0251 protein AL539_03370 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component AL539_03375 ENOG4108IJ7 Glycine betaine AL539_03380 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AL539_03385 ENOG4105RW8 MltA-interacting MipA family protein AL539_03400 ENOG4105ETT transcriptional Regulator, LysR family AL539_03425 ENOG4107RH7 Nicotinate phosphoribosyltransferase AL539_03435 ENOG4108RWI nicotinamidase AL539_03450 ENOG4105N2W Transcriptional regulator AL539_03455 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL539_03460 ENOG4105EA8 2-Nitropropane dioxygenase AL539_03465 ENOG4105CUB amino acid AL539_03470 ENOG4107FQ9 ethanolamine ammonia-lyase AL539_03475 ENOG4105CPD ethanolamine ammonia-lyase AL539_03480 ENOG4108K3Z AraC family transcriptional regulator AL539_03485 ENOG4107Z3H Transcriptional regulator, TetR family AL539_03505 ENOG4105N14 lysine exporter protein LysE YggA AL539_03515 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL539_03520 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL539_03525 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL539_03540 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AL539_03560 ENOG4105DTJ flagellar hook-associated protein AL539_03565 ENOG4105E1Q flagellar hook-associated protein AL539_03570 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL539_03575 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL539_03580 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL539_03585 ENOG4105CGA flagellar basal-body rod protein FlgG AL539_03590 ENOG4108KPB Flagellar basal-body rod protein FlgF AL539_03595 ENOG4105BZE flagellar hook protein, FlgE AL539_03600 ENOG4105W00 Flagellar hook capping protein AL539_03605 ENOG4108ZC9 flagellar basal-body rod protein flgc AL539_03610 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL539_03630 ENOG4105E4C Lytic transglycosylase catalytic AL539_03635 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL539_03655 ENOG4105EJQ L-serine dehydratase AL539_03670 ENOG4105ETT transcriptional Regulator, LysR family AL539_03675 ENOG4105UYK outer membrane protein a AL539_03685 ENOG4105CJP fad dependent oxidoreductase AL539_03695 ENOG4108MJ5 VirK protein AL539_03715 ENOG4107RCV ABC transporter, permease AL539_03730 ENOG4107STF Involved in phosphonate degradation (By similarity) AL539_03735 ENOG4108JPW Aminotransferase AL539_03740 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AL539_03750 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AL539_03755 ENOG4105KUU lipolytic protein G-D-S-L family AL539_03760 ENOG4105MKU Transcriptional regulator AL539_03775 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL539_03795 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL539_03805 ENOG4108UUE Transcriptional regulator AL539_03820 ENOG4105PAD Hydrolase AL539_03825 ENOG4105EXG Transcriptional regulator AL539_03860 ENOG4108UW5 maltose o-acetyltransferase AL539_03865 ENOG4108UKZ OsmC family AL539_03870 ENOG4105E0X reductase AL539_03885 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AL539_03890 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL539_03895 ENOG4106TD9 Diguanylate cyclase AL539_03910 ENOG4105BZU Histidine kinase AL539_03925 ENOG4105D9N nucleoside AL539_03945 ENOG4105C0F tryptophanase EC 4.1.99.1 AL539_03950 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL539_03955 ENOG4105C4M (Ubiquinol oxidase) subunit I AL539_03960 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL539_03975 ENOG4105D5U fad dependent oxidoreductase AL539_03995 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL539_04000 ENOG4105BZU Histidine kinase AL539_04005 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_04010 ENOG4105CQZ Histidine kinase AL539_04030 ENOG4105DUM transcriptional regulator, lysR family AL539_04055 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL539_04060 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL539_04070 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AL539_04075 ENOG4105CYW agmatinase AL539_04080 ENOG4105E5M Multidrug resistance protein D AL539_04085 ENOG4105CUG Oligopeptidase b AL539_04100 ENOG4105CC5 ABC transporter AL539_04105 ENOG4105DIK (ABC) transporter AL539_04110 ENOG4105DSE periplasmic solute binding protein AL539_04150 ENOG4109015 Biopolymer transport protein exbD tolR AL539_04175 ENOG410804D Sensor Signal Transduction Histidine Kinase AL539_04180 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL539_04185 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AL539_04195 ENOG4105C5I Dehydrogenase AL539_04200 ENOG4108YYI Protein of unknown function (DUF2810) AL539_04255 ENOG4108TEM pseudouridine methyltransferase AL539_04270 ENOG4105DWF phosphomethylpyrimidine kinase AL539_04275 ENOG4108YI8 ABC transporter AL539_04280 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AL539_04285 ENOG4107Z6I Thiamine biosynthesis protein AL539_04290 ENOG4105ETU transcriptional activator (TenA AL539_04295 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AL539_04300 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AL539_04310 ENOG4107QY8 reductase AL539_04315 ENOG4105CUW cytochrome C-TYPE protein AL539_04320 ENOG41068WN AL539_04325 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL539_04360 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL539_04365 ENOG4105BZW Glycerate kinase AL539_04370 ENOG4105C6Z Gluconate AL539_04375 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AL539_04410 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AL539_04425 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL539_04435 ENOG4105EIF outer membrane protein W AL539_04440 ENOG4107W31 Pentapeptide repeat protein AL539_04460 ENOG4105EW9 transcriptional regulator AsnC family AL539_04470 ENOG4105Q26 Siderophore-interacting protein AL539_04475 ENOG4105CC0 LysR family Transcriptional regulator AL539_04480 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AL539_04490 ENOG4105C4W S-formylglutathione hydrolase AL539_04500 ENOG4108KHX Diguanylate cyclase AL539_04510 ENOG4108HCJ Hydrolase AL539_04515 ENOG4105EJC lysr family transcriptional regulator AL539_04530 ENOG4105D3G Pseudouridine synthase AL539_04535 ENOG4105UQX Mate efflux family protein AL539_04540 ENOG4108K0B C-di-gmp phosphodiesterase AL539_04550 ENOG4105NBK UPF0345 protein AL539_04575 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL539_04590 ENOG4105DN9 Na H antiporter AL539_04610 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AL539_04615 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AL539_04625 ENOG4108VGI doxx family AL539_04630 ENOG4105C2I pirin domain protein AL539_04650 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AL539_04660 ENOG4105D6U Sodium Glutamate Symporter AL539_04665 ENOG4107U9B transcriptional regulator AL539_04670 ENOG4105CZV ABC transporter AL539_04680 ENOG4105D6U Sodium Glutamate Symporter AL539_04700 ENOG4105C8Q Methyl-accepting chemotaxis AL539_04705 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL539_04715 ENOG4108VAC response regulator AL539_04720 ENOG4108HRK Histidine kinase AL539_04750 ENOG4105CNI cell division protein FtsW AL539_04755 ENOG4105CDY transcriptional regulatory protein AL539_04765 ENOG4105BZU Histidine kinase AL539_04790 ENOG4108JQ7 (ABC) transporter AL539_04815 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AL539_04830 ENOG4105EQ2 LysR family Transcriptional regulator AL539_04840 ENOG4105FCK Membrane AL539_04845 ENOG4105C5Y PTS System AL539_04850 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL539_04860 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) AL539_04870 ENOG4108J59 Extracellular solute-binding protein, family 5 AL539_04890 ENOG4108JJA ABC, transporter AL539_04905 ENOG4107QZV Type I secretion membrane fusion protein AL539_04910 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_04915 ENOG4105CQZ Histidine kinase AL539_04920 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AL539_04935 ENOG4105C26 Dehydrogenase AL539_04945 ENOG4105CK7 Sodium proline symporter AL539_04975 ENOG4105EW9 transcriptional regulator AsnC family AL539_04985 ENOG4105BZ1 (ABC) transporter AL539_04995 ENOG4105C1J atp-dependent rna helicase AL539_05000 ENOG4108RPX mosc domain containing protein AL539_05025 ENOG4105ECQ AraC Family Transcriptional Regulator AL539_05055 ENOG4108JU3 Alkyl hydroperoxide reductase AL539_05060 ENOG4105D3R alkyl hydroperoxide reductase AL539_05065 ENOG4105K56 Transcriptional regulator AL539_05070 ENOG4108ZHJ Organic hydroperoxide resistance protein AL539_05120 ENOG4105C19 ABC transporter AL539_05140 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL539_05145 ENOG4105DBM Siderophore biosynthesis protein AL539_05155 ENOG4105DUU IucA IucC family protein AL539_05165 ENOG4105E0K tonB-dependent siderophore receptor AL539_05170 ENOG4105GAV receptor AL539_05175 ENOG4108HUF Transporter AL539_05180 ENOG4105DQ5 transport system permease protein AL539_05185 ENOG4108U1V ABC transporter, permease AL539_05190 ENOG4105E0A ABC, transporter AL539_05195 ENOG4105C8Q Methyl-accepting chemotaxis AL539_05200 ENOG4107RAN Peptidase, M16 AL539_05210 ENOG4105DR5 peptidase AL539_05225 ENOG4105E5M Multidrug resistance protein D AL539_05235 ENOG4105ETE Transcriptional regulator (LacI family AL539_05240 ENOG4107RJ1 sodium solute AL539_05255 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL539_05265 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL539_05270 ENOG4105ETE Transcriptional regulator (LacI family AL539_05275 ENOG4105CNV Aldolase AL539_05280 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AL539_05285 ENOG4105CHR reductase AL539_05310 ENOG4105D2S major facilitator superfamily AL539_05320 ENOG4105EJQ L-serine dehydratase AL539_05330 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AL539_05350 ENOG4108K8S endonuclease I AL539_05370 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AL539_05375 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AL539_05380 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL539_05405 ENOG41061ZR Transcriptional regulator AL539_05410 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AL539_05415 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AL539_05420 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AL539_05425 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AL539_05430 ENOG4107T9C Alpha amylase catalytic region AL539_05445 ENOG41074DU domain protein AL539_05450 ENOG4108P2H Inner membrane protein YjiG AL539_05455 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL539_05475 ENOG4105CK2 sodium dicarboxylate symporter AL539_05485 ENOG4105F04 LysR family Transcriptional regulator AL539_05490 ENOG4105N0V mono-oxygenase ydhR AL539_05520 ENOG4105DAY polysaccharide export protein AL539_05530 ENOG41081FY multiple antibiotic resistance (MarC)-related AL539_05535 ENOG4108NRW Phospholipase, patatin family AL539_05540 ENOG4108M1A Chitin-binding protein AL539_05550 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL539_05560 ENOG4105C72 UPF0176 protein AL539_05570 ENOG4105DZ1 carboxypeptidase AL539_05580 ENOG4108ZX5 transcriptional regulator AL539_05585 ENOG4108RCM Nitroreductase AL539_05595 ENOG4105ETT transcriptional Regulator, LysR family AL539_05600 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL539_05610 ENOG4105DP0 ferredoxin-NADP reductase AL539_05620 ENOG41068P6 UPF0319 protein AL539_05625 ENOG4105IPI Membrane AL539_05665 ENOG4105G2Y Transcriptional regulator AL539_05670 ENOG4105CNH Multidrug resistance protein MdtL AL539_05680 ENOG4105I4A GCN5-related N-acetyltransferase AL539_05690 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL539_05695 ENOG4105EB3 Histidine kinase AL539_05710 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL539_05715 ENOG4105F1A Pyruvate formate-lyase AL539_05720 ENOG4105C6N Formate acetyltransferase AL539_05740 ENOG4105KWG Pfam:DUF1696 AL539_05755 ENOG4105ER2 Ompa motb domain protein AL539_05760 ENOG4107RD7 Flagellar Motor Protein, MotA AL539_05785 ENOG4105MQ3 flagellar protein FliS AL539_05790 ENOG410804A Flagellar hook-associated 2 domain-containing protein AL539_05800 ENOG4105I03 Flagellin AL539_05815 ENOG4105D00 flagellar biosynthetic protein flhB AL539_05820 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL539_05825 ENOG4105VS8 Flagellar biosynthetic protein fliq AL539_05830 ENOG4105CN7 Flagellar biosynthetic protein FliP AL539_05835 ENOG4105DD5 Flagellar motor switch protein AL539_05850 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_05860 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL539_05865 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL539_05875 ENOG4108JIR Flagellum-specific ATP synthase AL539_05905 ENOG4107SSZ Phosphatase AL539_05925 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AL539_05930 ENOG4105EXG Transcriptional regulator AL539_05950 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL539_05960 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL539_05975 ENOG4105BZU Histidine kinase AL539_05980 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL539_05985 ENOG4105CPQ Dehydrogenase AL539_06020 ENOG4105D64 Mechanosensitive ion channel AL539_06030 ENOG4105DMF Dehydrogenase AL539_06035 ENOG4105DAA L-lactate AL539_06040 ENOG410642W LysR family Transcriptional regulator AL539_06050 ENOG4108JQ5 ABC transporter AL539_06060 ENOG4105DAN ATP-dependent protease AL539_06065 ENOG4105C8Q Methyl-accepting chemotaxis AL539_06070 ENOG4107QE9 Inherit from COG: Membrane AL539_06075 ENOG4105YE1 PilZ domain AL539_06090 ENOG4105WCN acetyltransferase AL539_06095 ENOG4108BGM Quinol dehydrogenase periplasmic component AL539_06100 ENOG4105GXZ Ferredoxin-type protein NapH AL539_06120 ENOG4108JJB ABC transporter AL539_06125 ENOG4108V7D UPF0397 protein AL539_06130 ENOG4105EFX secretion protein, HlyD family AL539_06135 ENOG4105KK7 inner membrane protein YiaW AL539_06140 ENOG4106TD9 Diguanylate cyclase AL539_06155 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL539_06160 ENOG4107SEY Conserved Protein AL539_06165 ENOG4108XDN Transcriptional regulator AL539_06170 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL539_06175 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AL539_06185 ENOG4105C1J atp-dependent rna helicase AL539_06190 ENOG4105CUG Oligopeptidase b AL539_06195 ENOG4107ENK receptor AL539_06215 ENOG4108NVR Methyl-accepting chemotaxis AL539_06220 ENOG4107S17 Phosphate-binding protein AL539_06225 ENOG4105C8U phosphate abc transporter AL539_06230 ENOG4105E2Z phosphate ABC transporter (Permease AL539_06235 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL539_06255 ENOG4107QVM von Willebrand factor, type A AL539_06270 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL539_06275 ENOG4105C8Q Methyl-accepting chemotaxis AL539_06285 ENOG41086KC Transcriptional regulator AL539_06290 ENOG41086KC Transcriptional regulator AL539_06300 ENOG4108JJ6 Type I secretion system ATPase AL539_06315 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL539_06320 ENOG4108HUF Transporter AL539_06325 ENOG4105E0A ABC, transporter AL539_06335 ENOG4105BZ1 (ABC) transporter AL539_06355 ENOG4105CZN Potassium uptake protein AL539_06360 ENOG4105ETT transcriptional Regulator, LysR family AL539_06370 ENOG4105DVW rieske (2Fe-2S) AL539_06375 ENOG4105C26 Dehydrogenase AL539_06380 ENOG4107QZF nitrite reductase NADPH large subunit AL539_06385 ENOG4105CJP fad dependent oxidoreductase AL539_06400 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AL539_06430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL539_06435 ENOG4105CH6 catalase AL539_06440 ENOG4108RXX maleylacetoacetate isomerase AL539_06445 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AL539_06450 ENOG4108WUH Transcriptional regulator, TetR family AL539_06455 ENOG4105V0I UPF0267 protein AL539_06495 ENOG4108F2G Chain length determinant protein AL539_06510 ENOG4105D3Q Sugar transferase AL539_06515 ENOG4108IJ9 (ABC) transporter AL539_06520 ENOG4107FKK extracellular solute-binding protein family 1 AL539_06525 ENOG4105D56 permease protein AL539_06530 ENOG4105EG2 ABC transporter, permease AL539_06560 ENOG4108JJ8 (ABC) transporter AL539_06590 ENOG4105CKW Inner membrane protein yedI AL539_06595 ENOG4105EKE dihydroorotase AL539_06610 ENOG4105QVC MOSC domain-containing protein AL539_06610 ENOG4105QVC MOSC domain-containing protein AL539_06615 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AL539_06620 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AL539_06660 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AL539_06665 ENOG4105EHG Permease protein AL539_06675 ENOG4106GFD transport protein AL539_06680 ENOG41090AP transport protein AL539_06685 ENOG4105WQ5 TonB family AL539_06690 ENOG4105D4P Coproporphyrinogen iii oxidase AL539_06695 ENOG41090JE Utilization Protein AL539_06700 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related AL539_06710 ENOG4107R88 Chemotaxis protein (CheV) AL539_06715 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AL539_06720 ENOG4107R73 Mate efflux family protein AL539_06725 ENOG4105C3U ABC transporter AL539_06730 ENOG4108JQ7 (ABC) transporter AL539_06735 ENOG4105DEF Extracellular solute-binding protein, family 5 AL539_06745 ENOG4105MVE transcriptional regulator AL539_06750 ENOG4105ZXK Dehydrogenase AL539_06755 ENOG4105G63 Type III effector Hrp-dependent AL539_06760 ENOG4105FB2 class II Aldolase AL539_06765 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AL539_06770 ENOG4105EXW epimerase dehydratase AL539_06775 ENOG4105C6Z Gluconate AL539_06780 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter AL539_06785 ENOG41061MD high-affinity nickel-transporter AL539_06795 ENOG4105C8Q Methyl-accepting chemotaxis AL539_06800 ENOG4105CR8 Transcriptional regulator AL539_06815 ENOG4105KXC Collagenase AL539_06825 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AL539_06830 ENOG4105VUF Transcriptional regulator AL539_06850 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL539_06855 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL539_06860 ENOG4108M6U Universal stress protein A AL539_06865 ENOG4105C5H ABC transporter AL539_06880 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL539_06890 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL539_06900 ENOG4108HK0 -acetyltransferase AL539_06925 ENOG4108IJF Heavy metal efflux pump, CzcA AL539_06945 ENOG4108IEG Formate dehydrogenase Alpha subunit AL539_06955 ENOG4107QWP ABC-2 type transporter AL539_06960 ENOG4105CJ1 ABC, transporter AL539_06970 ENOG4105JAB phenazine biosynthesis protein, phzf family AL539_06975 ENOG4108V1U phospholipid-binding protein AL539_06985 ENOG4105D6J arsenicaL-resistance protein AL539_07000 ENOG4105KVH Transcriptional regulator AL539_07025 ENOG4105JQN Transcriptional regulator AL539_07030 ENOG4107RGM aldo keto reductase AL539_07055 ENOG4105E0U tyrosine-specific transport protein AL539_07065 ENOG4105C8Q Methyl-accepting chemotaxis AL539_07070 ENOG4105DWD nucleoside recognition domain protein AL539_07095 ENOG4105DR5 peptidase AL539_07105 ENOG4105CR8 Transcriptional regulator AL539_07110 ENOG4105E5M Multidrug resistance protein D AL539_07125 ENOG4105VW4 glutaredoxin 3 AL539_07130 ENOG4108SXK Transporter Drug Metabolite Exporter family AL539_07145 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AL539_07190 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) AL539_07215 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AL539_07220 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL539_07225 ENOG4108V1T peptidylprolyl cis-trans isomerase AL539_07235 ENOG4105CDV Ompa motb domain protein AL539_07255 ENOG4105VEQ Cold shock protein AL539_07260 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system AL539_07265 ENOG4105BZU Histidine kinase AL539_07270 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL539_07280 ENOG4105BZ1 (ABC) transporter AL539_07290 ENOG4105DFG type I secretion outer membrane protein AL539_07295 ENOG4108MGY Histidine kinase AL539_07320 ENOG4108N3W hemolysin secretion protein AL539_07325 ENOG4108RMU ferritin dps family protein AL539_07340 ENOG4105C0A alcohol dehydrogenase AL539_07345 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AL539_07365 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL539_07370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL539_07375 ENOG4105MIR Phenylalanine 4-monooxygenase AL539_07380 ENOG41090A4 Pterin carbinolamine dehydratase AL539_07400 ENOG4105VRT cytoplasmic protein AL539_07440 ENOG4105DZR Type I site-specific deoxyribonuclease AL539_07455 ENOG41082EK Restriction modification system DNA (Specificity AL539_07460 ENOG4105CVR type I restriction-modification system AL539_07500 ENOG4108253 UPF0145 protein AL539_07580 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL539_07590 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL539_07600 ENOG4105VEQ Cold shock protein AL539_07610 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AL539_07620 ENOG4105CKI cobalamin synthesis protein AL539_07625 ENOG4105C1J atp-dependent rna helicase AL539_07645 ENOG4105CXC rtn protein AL539_07650 ENOG4105DKW ABC transporter AL539_07670 ENOG4105CVA phosphate AL539_07685 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) AL539_07690 ENOG4105C1J atp-dependent rna helicase AL539_07705 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL539_07710 ENOG4105EQ2 LysR family Transcriptional regulator AL539_07715 ENOG4105ENX hydrolase AL539_07720 ENOG4105ENX hydrolase AL539_07735 ENOG4105HF0 Membrane AL539_07750 ENOG4105MYN Zinc uptake regulation protein AL539_07765 ENOG4105CKI cobalamin synthesis protein AL539_07775 ENOG4105DR5 peptidase AL539_07785 ENOG4105CKI cobalamin synthesis protein AL539_07795 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AL539_07805 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AL539_07820 ENOG4107SDU Methyl-accepting chemotaxis AL539_07830 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL539_07835 ENOG4105E39 Enoyl-CoA hydratase AL539_07840 ENOG4107QX3 carboxylase AL539_07845 ENOG4105C1G acyl-Coa dehydrogenase AL539_07855 ENOG4105CHU acetyl-coa acetyltransferase AL539_07860 ENOG4105C26 Dehydrogenase AL539_07870 ENOG4105E39 Enoyl-CoA hydratase AL539_07875 ENOG4105E39 Enoyl-CoA hydratase AL539_07880 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL539_07885 ENOG4105CHR reductase AL539_07890 ENOG4105E2S oxidase) subunit II AL539_07895 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL539_07900 ENOG4105CCU oxidase (Subunit III) AL539_07910 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL539_07915 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL539_07930 ENOG4105C26 Dehydrogenase AL539_07970 ENOG4105E5Z arginine transporter ATP-binding subunit AL539_07975 ENOG4106PMH Extracellular solute-binding protein family 3 AL539_07980 ENOG4105GBT ABC transporter AL539_07985 ENOG4105DMR ABC, transporter AL539_07995 ENOG4105DUM transcriptional regulator, lysR family AL539_08010 ENOG4105EXG Transcriptional regulator AL539_08015 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL539_08020 ENOG4105C10 Electron transfer flavoprotein AL539_08025 ENOG4107QSN dihydrolipoamide acetyltransferase AL539_08035 ENOG4107RUY (E1 component), alpha subunit AL539_08050 ENOG4105R8A Heat shock protein AL539_08055 ENOG4106E5D Protein of unknown function (DUF461) AL539_08090 ENOG4105ETX regulatoR AL539_08120 ENOG4105BZU Histidine kinase AL539_08130 ENOG4105C44 Serine transporter AL539_08185 ENOG4105DG7 nitrate ABC transporter AL539_08190 ENOG4105D7T ABC transporter AL539_08195 ENOG4107QZF nitrite reductase NADPH large subunit AL539_08225 ENOG4105F8J Adenylate Guanylate cyclase AL539_08245 ENOG4105D9P serine threonine protein kinase AL539_08275 ENOG4105C3F Signal peptidase i AL539_08300 ENOG4105T95 Thiol disulfide interChange protein AL539_08385 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL539_08465 ENOG4105DAA L-lactate AL539_08470 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AL539_08475 ENOG4107QR9 Iron-sulfur cluster binding protein AL539_08480 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AL539_08485 ENOG4105CC0 LysR family Transcriptional regulator AL539_08555 ENOG4107QJE Chromosome Partitioning Protein AL539_08565 ENOG4105DZR Type I site-specific deoxyribonuclease AL539_08680 ENOG4105CNA YD repeat protein AL539_08690 ENOG4105CNA YD repeat protein AL539_08855 ENOG4105R8V Transcriptional regulator AL539_08980 ENOG4105EQN UPF0261 protein AL539_08990 ENOG4105KT5 UmuD protein AL539_09010 ENOG4105CVR type I restriction-modification system AL539_09015 ENOG4107QTH restriction modification system DNA specificity domain AL539_09025 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AL539_09035 ENOG4105DZR Type I site-specific deoxyribonuclease AL539_09060 ENOG4108UUM single-stranded DNA-binding protein AL539_09075 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AL539_09100 ENOG4108YGG dna repair protein AL539_09135 ENOG4105EQR Transposase IS116 IS110 IS902 AL539_09195 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL539_09275 ENOG4105DK2 UPF0207 protein AL539_09335 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AL539_09370 ENOG4105XPH Ferredoxin AL539_09430 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AL539_09460 ENOG410600T transposase AL539_09485 ENOG4108RNS Exports L-alanine (By similarity) AL539_09495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL539_09500 ENOG4105C4M (Ubiquinol oxidase) subunit I AL539_09515 ENOG4105C8Q Methyl-accepting chemotaxis AL539_09520 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL539_09525 ENOG4105BZS acriflavin resistance protein AL539_09560 ENOG4108NVR Methyl-accepting chemotaxis AL539_09570 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AL539_09660 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AL539_09705 ENOG4107R11 Transcriptional regulator AL539_09715 ENOG4105DCF alanine dehydrogenase AL539_09720 ENOG4105EW9 transcriptional regulator AsnC family AL539_09725 ENOG4105CNU cell division protein FtsK AL539_09730 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AL539_09735 ENOG4105D1H recombination factor protein RarA AL539_09740 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AL539_09755 ENOG4105KSC Transcriptional regulator, TraR DksA family AL539_09765 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AL539_09770 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL539_09780 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AL539_09790 ENOG4105D0M Protease HtpX homolog AL539_09800 ENOG4107FW0 short-chain dehydrogenase reductase AL539_09815 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AL539_09825 ENOG4105RHG AL539_09835 ENOG4107QTF adenylosuccinate lyase AL539_09840 ENOG41075W9 High frequency lysogenization protein HflD homolog AL539_09845 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AL539_09855 ENOG4107RE1 Inosine-guanosine kinase AL539_09860 ENOG4108YX2 DNA-binding protein AL539_09865 ENOG4107S6Z Na H antiporter AL539_09870 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AL539_09875 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AL539_09880 ENOG4105CIH Imidazole acetol-phosphate transaminase AL539_09910 ENOG4105K5B UPF0225 protein AL539_09915 ENOG4105D58 Diguanylate phosphodiesterase AL539_09920 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AL539_09925 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL539_09930 ENOG4105C8N cysteinyl-tRNA synthetase AL539_09935 ENOG4107104 thymidine kinase AL539_09965 ENOG4105TMB Formate nitrite transporter AL539_09975 ENOG4105C4B ABC transporter, permease AL539_09990 ENOG4108J2R molybdopterin oxidoreductase AL539_10005 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AL539_10015 ENOG4108JQ2 peptide transport system atp-binding protein AL539_10020 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AL539_10025 ENOG4108EU3 peptide transport system, permease AL539_10030 ENOG4108I5W peptide transport system, permease protein AL539_10035 ENOG4108J59 Extracellular solute-binding protein, family 5 AL539_10040 ENOG4105E51 psp operon transcriptional activator AL539_10045 ENOG41087YS Phage shock protein A AL539_10050 ENOG4105YYT phage shock protein B AL539_10055 ENOG4105FM1 phage shock protein C AL539_10075 ENOG4108R3E Dna-3-methyladenine glycosylase i AL539_10085 ENOG4107IFA Lipase (EC 3.1.1.3) AL539_10090 ENOG4105C28 cystathionine AL539_10095 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AL539_10100 ENOG4105C8J )-transporter AL539_10105 ENOG4108W1A pseudouridine synthase AL539_10115 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL539_10120 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AL539_10125 ENOG4108JUA Transcriptional regulator AL539_10140 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AL539_10145 ENOG4108VGW abc transporter atp-binding protein AL539_10150 ENOG4105CXZ ABC transporter, permease AL539_10155 ENOG4105VNH ABC transporter solute-binding protein AL539_10165 ENOG4105XZD Fe-S protein AL539_10180 ENOG4105CGH 5'-nucleotidase AL539_10190 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AL539_10195 ENOG4105EB3 Histidine kinase AL539_10200 ENOG4105ETX regulatoR AL539_10210 ENOG4105CFI type iii restriction protein res subunit AL539_10215 ENOG4105I08 Pseudouridine synthase AL539_10225 ENOG4105C2C drug resistance transporter, Bcr CflA AL539_10235 ENOG4105CGD Nad-dependent epimerase dehydratase AL539_10240 ENOG4107QI1 Mate efflux family protein AL539_10260 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AL539_10265 ENOG41067SE Tetr family transcriptional regulator AL539_10270 ENOG4107QPN acyl-Coa dehydrogenase AL539_10275 ENOG4105RKW reductase (By AL539_10280 ENOG4105D0C transport protein AL539_10285 ENOG41090BQ Glutaredoxin AL539_10295 ENOG4106KNT transcriptional regulator AL539_10300 ENOG4105DY8 decarboxylase AL539_10310 ENOG4105DWU Membrane AL539_10345 ENOG4105BZU Histidine kinase AL539_10355 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AL539_10360 ENOG4105BZC d-serine deaminase AL539_10365 ENOG4108JJ8 (ABC) transporter AL539_10370 ENOG4108JJ9 ABC, transporter AL539_10375 ENOG4105C3M thioredoxin reductase AL539_10395 ENOG4105BZU Histidine kinase AL539_10400 ENOG4105C8P )-transporter AL539_10405 ENOG4107GZ4 SanA protein AL539_10410 ENOG4107R1I NAD-dependent malic enzyme AL539_10415 ENOG4105CQ7 ATP-dependent helicase AL539_10430 ENOG4105C8V SAICAR synthetase AL539_10450 ENOG4105CDV Ompa motb domain protein AL539_10465 ENOG4105CQB FAD linked oxidase domain protein AL539_10480 ENOG4105C84 Histidine ammonia-lyase AL539_10490 ENOG41088SP formiminoglutamate hydrolase AL539_10495 ENOG4105CI2 imidazolone-5-propionate hydrolase AL539_10500 ENOG4105CZE histidine utilization repressor AL539_10515 ENOG4105C22 threonyL-tRNA synthetase AL539_10520 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AL539_10525 ENOG41082NX 50s ribosomal protein l35 AL539_10530 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AL539_10535 ENOG4105K8R UPF0145 protein AL539_10570 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AL539_10575 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AL539_10585 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL539_10595 ENOG4105FQ6 thiopurine methyltransferase AL539_10600 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AL539_10605 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) AL539_10610 ENOG41067MG lrgb family AL539_10615 ENOG4105VAW lrga family AL539_10620 ENOG4105CJB Exodeoxyribonuclease I AL539_10625 ENOG4108ETY sodium dicarboxylate symporter AL539_10630 ENOG4105K4T epimerase AL539_10635 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AL539_10640 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AL539_10660 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AL539_10665 ENOG4108IU2 vtamin B12-transporter permease AL539_10670 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AL539_10690 ENOG4105F04 LysR family Transcriptional regulator AL539_10700 ENOG4108VKG metal-dependent hydrolase AL539_10705 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AL539_10735 ENOG4105CTU Proline racemase AL539_10750 ENOG4105CIF Ornithine Cyclodeaminase AL539_10755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL539_10760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL539_10765 ENOG4105F38 ABC transporter, permease AL539_10770 ENOG4105D38 putrescine abc transporter AL539_10780 ENOG4107MM9 BNR Asp-box repeat-containing protein AL539_10790 ENOG4108JQ7 (ABC) transporter AL539_10795 ENOG4105C3U ABC transporter AL539_10800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL539_10805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL539_10810 ENOG4107QSI ABC, transporter AL539_10815 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL539_10820 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AL539_10825 ENOG4105F1J Homogentisate 1,2-dioxygenase AL539_10835 ENOG4108RXX maleylacetoacetate isomerase AL539_11000 ENOG4107S6Z Na H antiporter AL539_11005 ENOG4105CFQ glutamine synthetase AL539_11015 ENOG4108Z86 Glutamine amidotransferase AL539_11020 ENOG4107VRI Transcriptional regulator AL539_11025 ENOG4105C26 Dehydrogenase AL539_11030 ENOG4105CJP fad dependent oxidoreductase AL539_11040 ENOG4105DWY Agmatine deiminase AL539_11045 ENOG4105C26 Dehydrogenase AL539_11050 ENOG4108JPW Aminotransferase AL539_11055 ENOG4105BZU Histidine kinase AL539_11065 ENOG4108ZT1 Transcriptional regulator AL539_11070 ENOG4105MSB protein, conserved in bacteria AL539_11095 ENOG4105BZU Histidine kinase AL539_11100 ENOG4105BZU Histidine kinase AL539_11110 ENOG41090FY type IV pilus biogenesis stability protein PilW AL539_11115 ENOG4105CVG Homoserine O-transsuccinylase AL539_11130 ENOG4105D1S lipid A biosynthesis AL539_11135 ENOG4105CTD carboxy-peptidase AL539_11140 ENOG410829K Lysine exporter protein (Lyse ygga) AL539_11150 ENOG4105BZG amino acid carrier protein AL539_11175 ENOG4105E0M Sulfatase AL539_11180 ENOG4105GIJ Glycine betaine AL539_11185 ENOG4108HQS Glycine betaine AL539_11190 ENOG4108IJ7 Glycine betaine AL539_11205 ENOG4105C94 Transporter AL539_11210 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase AL539_11215 ENOG4108JPW Aminotransferase AL539_11220 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AL539_11225 ENOG4105CZK Aspartate kinase AL539_11230 ENOG4105ENH Sulfatase AL539_11245 ENOG4105C4X radical SAM domain protein AL539_11260 ENOG4105ENH Sulfatase AL539_11265 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AL539_11285 ENOG4105DFG type I secretion outer membrane protein AL539_11300 ENOG4105E98 transcriptional regulator DeoR family AL539_11305 ENOG4105D9R oxidoreductase AL539_11310 ENOG41090KN UPF0303 protein AL539_11315 ENOG4105BZU Histidine kinase AL539_11335 ENOG4105C8P )-transporter AL539_11345 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_11350 ENOG4105BZU Histidine kinase AL539_11355 ENOG4105CPI Metal Dependent Phosphohydrolase AL539_11360 ENOG410829K Lysine exporter protein (Lyse ygga) AL539_11365 ENOG4105G0K glycine radical enzyme YjjI family AL539_11370 ENOG41076CZ activating enzyme AL539_11380 ENOG4105EE5 Membrane protein terC AL539_11390 ENOG4105DHT Metal Dependent Phosphohydrolase AL539_11400 ENOG4105E0U tyrosine-specific transport protein AL539_11405 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AL539_11415 ENOG4105E0A ABC, transporter AL539_11420 ENOG4105J76 Periplasmic binding protein AL539_11425 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL539_11430 ENOG4105E0K tonB-dependent siderophore receptor AL539_11440 ENOG4105BZ1 (ABC) transporter AL539_11445 ENOG4105BZ1 (ABC) transporter AL539_11450 ENOG4108VAU general secretion pathway protein G AL539_11460 ENOG4105CR8 Transcriptional regulator AL539_11485 ENOG4105CFG Acts as a chaperone (By similarity) AL539_11490 ENOG4105CFG Acts as a chaperone (By similarity) AL539_11535 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AL539_11540 ENOG4105CQ7 ATP-dependent helicase AL539_11555 ENOG4105C94 Transporter AL539_11570 ENOG4107R8N Glycosyl transferase, family 2 AL539_11575 ENOG4105CPK Glycosyl transferase (Group 1 AL539_11605 ENOG4107TYR Glycosyl Transferase AL539_11615 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_11630 ENOG4107V1M polysaccharide export protein AL539_11640 ENOG41082AN stage II sporulation protein AL539_11655 ENOG4107QI1 Mate efflux family protein AL539_11660 ENOG4108R6K riboflavin synthase, subunit alpha AL539_11670 ENOG4105FGM Fructosamine kinase AL539_11680 ENOG4105BZU Histidine kinase AL539_11690 ENOG4107TT5 NLP P60 protein AL539_11725 ENOG4106IUH DTW domain containing protein AL539_11730 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AL539_11740 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL539_11745 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AL539_11750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL539_11765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_11770 ENOG4105BZU Histidine kinase AL539_11780 ENOG4105C5H ABC transporter AL539_11785 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL539_11805 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL539_11815 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL539_11820 ENOG4105QAX Iron-sulfur AL539_11960 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AL539_11965 ENOG4107RUE extracellular solute-binding protein family 1 AL539_11970 ENOG4107RUE extracellular solute-binding protein family 1 AL539_11975 ENOG4105D38 putrescine abc transporter AL539_11980 ENOG4105F38 ABC transporter, permease AL539_11985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL539_12005 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AL539_12010 ENOG4105Q9Y Universal stress protein AL539_12015 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL539_12030 ENOG4105C59 p-type ATPase AL539_12040 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) AL539_12055 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AL539_12100 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) AL539_12105 ENOG4105DAN ATP-dependent protease AL539_12110 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AL539_12125 ENOG4105C5H ABC transporter AL539_12135 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AL539_12140 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AL539_12145 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AL539_12150 ENOG4105C7I Dehydrogenase AL539_12160 ENOG4105CD8 aminopeptidase N AL539_12170 ENOG4105CN1 protease AL539_12175 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AL539_12180 ENOG4108ZGC gaf domain protein AL539_12185 ENOG4105BZ1 (ABC) transporter AL539_12190 ENOG4105H2K paraquat-inducible protein a AL539_12195 ENOG4105DY2 Paraquat-inducible protein b AL539_12200 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL539_12220 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL539_12225 ENOG4108VPT UPF0234 protein AL539_12240 ENOG4107QXX ABC transporter AL539_12245 ENOG4105EZ7 amino acid ABC transporter AL539_12250 ENOG4105DRP amino acid AbC transporter AL539_12255 ENOG4105CDA abc transporter atp-binding protein AL539_12260 ENOG4108MN8 Membrane AL539_12270 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AL539_12275 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AL539_12280 ENOG4105C8Q Methyl-accepting chemotaxis AL539_12285 ENOG4105DR4 Methyltransferase AL539_12300 ENOG4105KCK Peptidoglycan-associated lipoprotein AL539_12330 ENOG4105CDV Ompa motb domain protein AL539_12340 ENOG4105BZU Histidine kinase AL539_12345 ENOG4107HP6 Transcriptional regulator AL539_12355 ENOG4105CV8 reductase AL539_12360 ENOG4105HEI LysR family (Transcriptional regulator AL539_12370 ENOG4105HEI LysR family (Transcriptional regulator AL539_12375 ENOG4105F27 Major Facilitator AL539_12390 ENOG41063TF transcriptional regulator (AraC AL539_12395 ENOG4108W2Y isochorismatase AL539_12400 ENOG4106PMH Extracellular solute-binding protein family 3 AL539_12410 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AL539_12415 ENOG4105C3R Methionine synthase AL539_12420 ENOG4105CDA abc transporter atp-binding protein AL539_12425 ENOG4105EAD ABC transporter AL539_12430 ENOG4106PMH Extracellular solute-binding protein family 3 AL539_12445 ENOG4105CC0 LysR family Transcriptional regulator AL539_12460 ENOG4105HEI LysR family (Transcriptional regulator AL539_12470 ENOG41090KR LysR family transcriptional Regulator AL539_12485 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AL539_12490 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AL539_12495 ENOG410667J hydrolase AL539_12505 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AL539_12515 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL539_12520 ENOG4105C7F AcnD-accessory protein PrpF AL539_12525 ENOG4108I0Z Aconitate hydratase AL539_12530 ENOG4105BZN citrate synthase AL539_12535 ENOG4105CR4 methylisocitrate lyase AL539_12570 ENOG4105EJ9 Membrane AL539_12685 ENOG4105E7U AraC family transcriptional regulator AL539_12755 ENOG41066XE Type III export protein AL539_12785 ENOG4108KB1 transcriptional regulator, arac family AL539_12805 ENOG4105C26 Dehydrogenase AL539_12810 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AL539_12825 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AL539_12830 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) AL539_12835 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AL539_12850 ENOG4106YYS transcriptional regulatory protein AL539_12855 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AL539_12870 ENOG4107KET secretion protein, HlyD family AL539_12885 ENOG4105DUM transcriptional regulator, lysR family AL539_12900 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AL539_12905 ENOG4105CEB Aspartate aminotransferase AL539_12910 ENOG4105D0C transport protein AL539_12920 ENOG4105Y49 secretion protein, HlyD family AL539_12940 ENOG4107RZC phospholipase d AL539_12950 ENOG41090VV Protein of unknown function (DUF2846) AL539_12955 ENOG4105N14 lysine exporter protein LysE YggA AL539_12965 ENOG4105KCV RNA signal recognition particle 4.5S RNA AL539_12985 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL539_12990 ENOG41068WN AL539_12995 ENOG4108UW5 maltose o-acetyltransferase AL539_13105 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AL539_13645 ENOG4105K4U addiction module toxin, RelE StbE family AL539_13680 ENOG4105K4U addiction module toxin, RelE StbE family AL539_13690 ENOG4105K4U addiction module toxin, RelE StbE family AL539_13790 ENOG4105D9U N-acetyltransferase AL539_13800 ENOG4106K28 UPF0283 membrane protein AL539_13805 ENOG4105CM6 amino acid regulated cytosolic protein AL539_13825 ENOG4105CRQ synthase (Component I) AL539_13840 ENOG4105P8F nudix hydrolase AL539_13845 ENOG4105C44 Serine transporter AL539_13850 ENOG4105EJQ L-serine dehydratase AL539_13855 ENOG4105BZU Histidine kinase AL539_13865 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AL539_13870 ENOG4105C8Q Methyl-accepting chemotaxis AL539_13875 ENOG4105C5S asparaginyl-tRNA synthetase AL539_13885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL539_13900 ENOG4105CGF Aromatic amino acid aminotransferase AL539_13920 ENOG4105C8Q Methyl-accepting chemotaxis AL539_13925 ENOG4105C94 Transporter AL539_13945 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL539_13955 ENOG4105CH5 extracellular solute-binding protein, family 7 AL539_13970 ENOG4105C5X domain protein AL539_13975 ENOG4105EAQ (twin-arginine translocation) pathway signal AL539_13980 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AL539_14005 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AL539_14015 ENOG4108DMF Cytochrome C biogenesis protein AL539_14020 ENOG4107QX9 Thiol disulfide interChange protein AL539_14025 ENOG4105DA4 cytochrome c-type biogenesis protein AL539_14030 ENOG4105DVI reductase, NrfD AL539_14035 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL539_14045 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AL539_14060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL539_14065 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL539_14075 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL539_14080 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL539_14105 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) AL539_14145 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AL539_14150 ENOG4105WH1 Two component transcriptional regulator luxr family AL539_14155 ENOG4105CQ2 DNA polymerase AL539_14170 ENOG4108W5H UPF0263 protein AL539_14175 ENOG4105FE9 pseudouridine synthase AL539_14185 ENOG4107RTD sua5 ycio yrdc ywlc family protein AL539_14190 ENOG4105DB7 PHP domain protein AL539_14200 ENOG4105CRQ synthase (Component I) AL539_14205 ENOG4105DDQ anthranilate synthase AL539_14210 ENOG4108I0Q anthranilate phosphoribosyltransferase AL539_14215 ENOG4105DK0 Indole-3-glycerol phosphate synthase AL539_14220 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL539_14225 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AL539_14230 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL539_14235 ENOG4105CEY Amp-dependent synthetase and ligase AL539_14245 ENOG4105CK2 sodium dicarboxylate symporter AL539_14255 ENOG4105BZU Histidine kinase AL539_14265 ENOG4107835 probably involved in intracellular septation (By similarity) AL539_14270 ENOG4105NAU thioesterase Superfamily protein AL539_14275 ENOG4105K9H YciI-like protein AL539_14285 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL539_14290 ENOG4105DZ2 Transcriptional regulator AL539_14310 ENOG4105CCT upf0313 protein AL539_14335 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AL539_14345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL539_14350 ENOG41062D9 Histidine kinase AL539_14365 ENOG4105JQN Transcriptional regulator AL539_14370 ENOG4105J12 Multidrug resistance protein mdtN AL539_14380 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL539_14400 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL539_14410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL539_14420 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL539_14440 ENOG4105N6Y Thioredoxin AL539_14445 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL539_14455 ENOG4108ZXC Two component transcriptional regulator, luxr family AL539_14460 ENOG4106AFQ Histidine kinase AL539_14465 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL539_14470 ENOG4106WHD Tetrathionate reductase AL539_14475 ENOG4105DB1 molybdopterin oxidoreductase AL539_14485 ENOG4105NQN cytochrome C AL539_14490 ENOG4105F1S paraquat-inducible protein a AL539_14495 ENOG4105DY2 Paraquat-inducible protein b AL539_14515 ENOG4108J59 Extracellular solute-binding protein, family 5 AL539_14520 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AL539_14525 ENOG4105CFV Tetratricopeptide repeat protein AL539_14530 ENOG4105Q4A inner membrane protein yciS AL539_14535 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL539_14540 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AL539_14545 ENOG4105CAT Cytidine monophosphate kinase AL539_14550 ENOG4105ERU peptidase AL539_14555 ENOG4105UBK short-chain dehydrogenase reductase AL539_14570 ENOG4105C0B DNA polymerase III (alpha subunit) AL539_14575 ENOG4107R88 Chemotaxis protein (CheV) AL539_14580 ENOG4105DAG ROK family AL539_14585 ENOG4105CA9 Pyruvate kinase AL539_14590 ENOG4108NRW Phospholipase, patatin family AL539_14605 ENOG4105C8J )-transporter AL539_14615 ENOG4105CI1 PTS System AL539_14620 ENOG4105F8V Hydrolase, tatD family AL539_14625 ENOG4107QRG dna polymerase iii AL539_14630 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AL539_14635 ENOG4105HHA aminodeoxychorismate lyase AL539_14645 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL539_14650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL539_14655 ENOG4105CHR reductase AL539_14660 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AL539_14665 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL539_14670 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AL539_14675 ENOG4105VGS 50s ribosomal protein l32 AL539_14680 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AL539_14685 ENOG4108UHJ MAF-like protein AL539_14690 ENOG4105EI2 Pseudouridine synthase AL539_14700 ENOG4105C03 ribonuclease AL539_14710 ENOG4105CHH sulfate transporter AL539_14720 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AL539_14730 ENOG4105DBI uridine monophosphokinase AL539_14735 ENOG4105D1F ATP-binding protein AL539_14740 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AL539_14765 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AL539_14775 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AL539_14780 ENOG4106RHG Yeca family AL539_14785 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AL539_14790 ENOG4105BZU Histidine kinase AL539_14795 ENOG4107R28 alpha amylase, catalytic region AL539_14800 ENOG4108JJB ABC transporter AL539_14805 ENOG4105C7J ABC transporter, permease AL539_14815 ENOG4105PQ6 UPF0208 membrane protein AL539_14820 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL539_14825 ENOG4108DNC Involved in acetate metabolism (By similarity) AL539_14835 ENOG4105CHF Glutathione S-transferase AL539_14840 ENOG4108JQ7 (ABC) transporter AL539_14845 ENOG4105C3U ABC transporter AL539_14850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL539_14855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL539_14860 ENOG4107QSI ABC, transporter AL539_14870 ENOG4108ZAF Molybdopterin AL539_14875 ENOG4105M00 molybdopterin converting factor, subunit 1 AL539_14880 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL539_14885 ENOG4108RIR Molybdenum cofactor biosynthesis protein AL539_14890 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL539_14895 ENOG4105CHW UPF0052 protein AL539_14905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_14910 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AL539_14920 ENOG4105C6N Formate acetyltransferase AL539_14925 ENOG4105DGN Electron transport complex AL539_14930 ENOG4108R3D Electron transport complex AL539_14940 ENOG4105D6A Electron transport complex AL539_14945 ENOG4108UQQ Electron transport complex AL539_14950 ENOG4105DZB Electron transport complex AL539_14955 ENOG4105CSM endonuclease III AL539_14960 ENOG4108UYE Lactoylglutathione lyase AL539_14965 ENOG4106WH9 Protein of unknown function (DUF2753) AL539_14970 ENOG4105EIY sodium-type flagellar protein motY AL539_14980 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AL539_14985 ENOG4105D3Y Na H antiporter AL539_15005 ENOG4105M2J Glutaredoxin AL539_15010 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL539_15025 ENOG4108EKI Dehydrogenase AL539_15030 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AL539_15035 ENOG4105EYW Ion transport protein AL539_15040 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL539_15045 ENOG4105DFD Na H antiporter AL539_15060 ENOG4106V8H Nucleoid-associated protein AL539_15065 ENOG4105YDX UPF0352 protein AL539_15070 ENOG4105E68 Sulfatase AL539_15080 ENOG4105DGU Histone deacetylase AL539_15085 ENOG4108RU0 short-chain dehydrogenase reductase AL539_15095 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL539_15100 ENOG41069NU Nitroreductase AL539_15110 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL539_15115 ENOG4105D07 Signal peptide peptidase, SppA AL539_15120 ENOG4105HDK L-asparaginase AL539_15125 ENOG4105VUT cytoplasmic protein AL539_15135 ENOG4105E0X reductase AL539_15140 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL539_15145 ENOG4105DSB aldose 1-epimerase AL539_15150 ENOG4107SDU Methyl-accepting chemotaxis AL539_15155 ENOG4105DHI Methyltransferase AL539_15175 ENOG4105G6Z alkaline phosphatase AL539_15190 ENOG41067V3 Antibiotic biosynthesis monooxygenase AL539_15200 ENOG4108ZZ3 UPF0260 protein AL539_15205 ENOG4105Y3U Transglycosylase-associated protein AL539_15210 ENOG4105KRS Proteinase inhibitor AL539_15215 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL539_15220 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AL539_15225 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AL539_15230 ENOG4107QMP dna polymerase iii subunits gamma and tau AL539_15235 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AL539_15240 ENOG4105WD1 Membrane AL539_15250 ENOG4105I93 response regulator AL539_15255 ENOG4105EJC lysr family transcriptional regulator AL539_15260 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AL539_15265 ENOG4105E96 Colicin v production protein AL539_15270 ENOG4108S3P Sporulation domain protein AL539_15275 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AL539_15280 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AL539_15290 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AL539_15300 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL539_15305 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AL539_15315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL539_15320 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AL539_15325 ENOG4105Q8W reductase AL539_15335 ENOG4105MH2 YfcL protein AL539_15340 ENOG4108BPE -transporting atpase AL539_15350 ENOG4105EN6 Membrane AL539_15355 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AL539_15360 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AL539_15365 ENOG4108DG9 Smr protein MutS2 AL539_15370 ENOG4108BY2 phosphohistidine phosphatase AL539_15375 ENOG4107QXK peptidase AL539_15385 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL539_15390 ENOG4105CHU acetyl-coa acetyltransferase AL539_15410 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL539_15415 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL539_15450 ENOG4105EQN UPF0261 protein AL539_15460 ENOG410903C (LipO)protein AL539_15465 ENOG4105KWW Biogenesis protein AL539_15470 ENOG4108M1T Cytochrome c-type biogenesis protein AL539_15475 ENOG4107QX9 Thiol disulfide interChange protein AL539_15480 ENOG4105DA4 cytochrome c-type biogenesis protein AL539_15485 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AL539_15490 ENOG4105X3C heme exporter protein AL539_15495 ENOG41060IM Heme exporter protein AL539_15500 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AL539_15505 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AL539_15515 ENOG4108V3W Chemotaxis protein, CheW AL539_15525 ENOG4107QJE Chromosome Partitioning Protein AL539_15530 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AL539_15535 ENOG4105CBS Chea signal transduction histidine kinase AL539_15540 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AL539_15545 ENOG4108VYJ response regulator receiver protein AL539_15550 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL539_15555 ENOG4107R21 site-determining protein AL539_15560 ENOG4105FZW flagellar biosynthesis regulator FlhF AL539_15565 ENOG4105D7B Flagellar biosynthesis protein flha AL539_15570 ENOG4105D00 flagellar biosynthetic protein flhB AL539_15575 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL539_15580 ENOG4105VS8 Flagellar biosynthetic protein fliq AL539_15585 ENOG4105CN7 Flagellar biosynthetic protein FliP AL539_15590 ENOG4105VTB flagellar biosynthesis protein fliO AL539_15595 ENOG4105DD5 Flagellar motor switch protein AL539_15600 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL539_15625 ENOG4108JIR Flagellum-specific ATP synthase AL539_15635 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL539_15640 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL539_15645 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AL539_15650 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_15655 ENOG4105BZU Histidine kinase AL539_15660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_15665 ENOG4105MQ3 flagellar protein FliS AL539_15675 ENOG4107BRV flagellar capping protein AL539_15680 ENOG41063QE flagellar protein FlaG AL539_15685 ENOG4105I03 Flagellin AL539_15690 ENOG4105I03 Flagellin AL539_15700 ENOG4105I03 Flagellin AL539_15705 ENOG4105EZR dyp-type peroxidase family protein AL539_15710 ENOG4105QZU Inner membrane protein YfeZ AL539_15730 ENOG4105KUZ arsenate reductase AL539_15735 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL539_15750 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL539_15765 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL539_15780 ENOG4105ERG peptidase m48, ste24p AL539_15785 ENOG4105K89 arsenate reductase AL539_15790 ENOG4105CS1 NAD(P)H quinone oxidoreductase AL539_15805 ENOG4105C2W permease AL539_15815 ENOG4105CXB phosphoribosylaminoimidazole synthetase AL539_15820 ENOG4108V3E phosphoribosylglycinamide formyltransferase AL539_15825 ENOG4105E7A Glutamine amidotransferase AL539_15830 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL539_15835 ENOG4107QPN acyl-Coa dehydrogenase AL539_15865 ENOG4108JDX DNA polymerase iii, epsilon subunit AL539_15870 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL539_15875 ENOG4105D1A Methyltransferase AL539_15880 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AL539_15885 ENOG4105E9H Lytic Murein transglycosylase AL539_15895 ENOG4107NA1 Endonuclease Exonuclease phosphatase AL539_15900 ENOG4108YZA Nitrogen regulatory protein pii AL539_15905 ENOG4105N7H Cytochrome AL539_15910 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AL539_15915 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AL539_15920 ENOG4105C0B DNA polymerase III (alpha subunit) AL539_15925 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL539_15930 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL539_15935 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL539_15940 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL539_15945 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL539_15950 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AL539_15960 ENOG4105DZP Membrane-associated zinc metalloprotease AL539_15965 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AL539_15970 ENOG4105KNE Phosphatidate cytidylyltransferase AL539_15975 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AL539_15980 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AL539_15985 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AL539_15990 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AL539_15995 ENOG4105CE9 30S ribosomal protein S2 AL539_16000 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AL539_16005 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AL539_16010 ENOG4108T8E UPF0325 protein AL539_16015 ENOG4105DR9 pseudouridine synthase AL539_16020 ENOG4105WP7 tRNA pseudouridine synthase C AL539_16050 ENOG4108UPT UPF0178 protein AL539_16055 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL539_16060 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AL539_16085 ENOG4105CFC Transporter AL539_16095 ENOG4105NRA 50s ribosomal protein l31 type b AL539_16100 ENOG4108R96 Methyltransferase, YaeB family AL539_16105 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AL539_16115 ENOG4105W1I UPF0253 protein AL539_16125 ENOG4105C8J )-transporter AL539_16140 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL539_16145 ENOG4105C9U ATP-dependent DNA helicase RecQ AL539_16150 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AL539_16160 ENOG4105BZU Histidine kinase AL539_16170 ENOG4105CJ2 (LipO)protein AL539_16175 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AL539_16180 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL539_16185 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL539_16190 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL539_16195 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL539_16200 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL539_16205 ENOG4105M85 Bola protein AL539_16210 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL539_16215 ENOG4105IEY (LipO)protein AL539_16220 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL539_16235 ENOG4105K6V RNA polymerase AL539_16255 ENOG4105DRB nucleoside-specific channel-forming protein AL539_16260 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AL539_16265 ENOG4107S0N DJ-1 family AL539_16270 ENOG4105C9B Cysteine desulfurase AL539_16275 ENOG4105BZU Histidine kinase AL539_16280 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AL539_16285 ENOG4105CUZ uba thif-type nad fad binding protein AL539_16290 ENOG4105CA3 membrane-bound lytic murein transglycosylase AL539_16305 ENOG4107QZM n-acetylglutamate synthase AL539_16325 ENOG4107QYX exodeoxyribonuclease v alpha AL539_16330 ENOG4107QKA exodeoxyribonuclease V beta AL539_16335 ENOG4105DSY exodeoxyribonuclease V, gamma AL539_16340 ENOG4105E68 Sulfatase AL539_16350 ENOG4105EVZ LysR family transcriptional regulator AL539_16355 ENOG4105X2V dna damage-inducible protein AL539_16370 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AL539_16375 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AL539_16380 ENOG4105CXY transporter AL539_16390 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL539_16395 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AL539_16400 ENOG4105E98 transcriptional regulator DeoR family AL539_16405 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AL539_16410 ENOG4107RX3 Mg2 transporter protein cora family protein AL539_16430 ENOG4105CQ4 Transcriptional regulator AL539_16435 ENOG41064T2 transcriptional regulator, lysR family AL539_16445 ENOG41086KC Transcriptional regulator AL539_16475 ENOG4108IQE Amp-dependent synthetase and ligase AL539_16485 ENOG4105ETT transcriptional Regulator, LysR family AL539_16490 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL539_16495 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AL539_16505 ENOG4105EAC phosphoserine phosphatase AL539_16515 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL539_16520 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AL539_16525 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AL539_16530 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AL539_16535 ENOG4105D9N nucleoside AL539_16540 ENOG4105EYA deoxyribonuclease AL539_16550 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AL539_16570 ENOG4108YYD acetyltransferase AL539_16575 ENOG4105XPQ lipid carrier protein AL539_16585 ENOG4105BZU Histidine kinase AL539_16590 ENOG4105CFP Peptidase U32 AL539_16595 ENOG4106RZ4 Peptidase U32 AL539_16600 ENOG4105C3S Mate efflux family protein AL539_16615 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AL539_16620 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AL539_16625 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AL539_16630 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AL539_16635 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AL539_16640 ENOG4105CHV Transcription elongation factor NusA AL539_16645 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AL539_16670 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AL539_16675 ENOG4105EEI dihydropteroate synthase AL539_16680 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AL539_16685 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AL539_16690 ENOG4105HBR Rna-binding protein AL539_16695 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL539_16700 ENOG4107QE9 Inherit from COG: Membrane AL539_16705 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AL539_16715 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL539_16720 ENOG4105DR5 peptidase AL539_16735 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AL539_16740 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AL539_16745 ENOG4105F4G Membrane AL539_16750 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL539_16755 ENOG4105BZU Histidine kinase AL539_16760 ENOG4107QRA Extracellular solute-binding protein, family 5 AL539_16770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL539_16775 ENOG4105C3U ABC transporter AL539_16780 ENOG4108JQ7 (ABC) transporter AL539_16790 ENOG4105RD7 BadF BadG BcrA BcrD AL539_16795 ENOG4105E2D ec 3.2.1.52 AL539_16810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL539_16830 ENOG4108YZA Nitrogen regulatory protein pii AL539_16835 ENOG4105XTV UPF0231 protein AL539_16840 ENOG4107QIJ Aconitate hydratase 2 AL539_16845 ENOG4105D78 K07001 NTE family protein AL539_16850 ENOG4105BZ4 penicillin-binding protein AL539_16855 ENOG4105CQ7 ATP-dependent helicase AL539_16860 ENOG4105PW4 Sugar fermentation stimulation protein homolog AL539_16865 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AL539_16870 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AL539_16875 ENOG4105DJ0 Poly(A) Polymerase AL539_16880 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL539_16885 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AL539_16890 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AL539_16895 ENOG4105D1S lipid A biosynthesis AL539_16905 ENOG4105E3A (ABC) transporter AL539_16910 ENOG4105DA5 (ABC) transporter AL539_16915 ENOG4105CHH sulfate transporter AL539_16920 ENOG41077A9 carbonic anhydrase AL539_16925 ENOG4108UGV hypoxanthine phosphoribosyltransferase AL539_16930 ENOG410630P Transcriptional regulator AL539_16935 ENOG4107QN2 dihydrolipoyl dehydrogenase AL539_16940 ENOG4107QSN dihydrolipoamide acetyltransferase AL539_16945 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AL539_16950 ENOG41073TP transcriptional regulator AL539_16960 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AL539_16970 ENOG4107QHF type ii secretion system protein e AL539_16975 ENOG4105D7Q type ii secretion system AL539_16980 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AL539_16985 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AL539_16990 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AL539_16995 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AL539_17000 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AL539_17005 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AL539_17010 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AL539_17015 ENOG4105K5M 30s ribosomal protein S16 AL539_17020 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AL539_17025 ENOG4106KVJ cytochrome C assembly protein AL539_17030 ENOG4108JU6 CBS domain protein AL539_17045 ENOG4105D9M gamma-glutamylcysteine synthetase AL539_17055 ENOG4105W39 Membrane AL539_17065 ENOG4105D9Q decarboxylase (Beta subunit) AL539_17070 ENOG4107QSA Oxaloacetate decarboxylase AL539_17130 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AL539_17135 ENOG4105CFH Aspartokinase AL539_17140 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL539_17145 ENOG4105Y3E Modulates RecA activity (By similarity) AL539_17150 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AL539_17155 ENOG4107TH8 cina domain protein AL539_17160 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AL539_17165 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL539_17175 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AL539_17180 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AL539_17185 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AL539_17190 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AL539_17195 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AL539_17200 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL539_17205 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AL539_17210 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AL539_17215 ENOG4105DXN mazG family AL539_17220 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL539_17230 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AL539_17240 ENOG4105BZU Histidine kinase AL539_17245 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AL539_17250 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AL539_17255 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AL539_17260 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AL539_17265 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AL539_17270 ENOG4105C3F Signal peptidase i AL539_17275 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AL539_17295 ENOG4105EMN RNA polymerase sigma factor AL539_17305 ENOG4108IYU L-aspartate oxidase AL539_17315 ENOG4105Y75 tpr repeat protein AL539_17320 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AL539_17335 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL539_17340 ENOG4105D0A hydroxylase AL539_17355 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AL539_17365 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AL539_17370 ENOG4105E66 phosphoriboisomerase A AL539_17375 ENOG4108JQ1 Dehydrogenase AL539_17380 ENOG4105MPN Membrane AL539_17385 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AL539_17400 ENOG4105D64 Mechanosensitive ion channel AL539_17405 ENOG4105D2N Aldolase AL539_17410 ENOG4105BZA Phosphoglycerate kinase AL539_17415 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL539_17420 ENOG4105D05 Receptor AL539_17425 ENOG4108R4R Iron-regulated virulence regulatory protein AL539_17430 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL539_17440 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AL539_17450 ENOG4105GPY SprT protein AL539_17455 ENOG4105RWS endonuclease I AL539_17460 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AL539_17465 ENOG4105D7Z glutathione synthase AL539_17470 ENOG4108UJU UPF0301 protein AL539_17475 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AL539_17480 ENOG4105CZX twitching motility protein AL539_17485 ENOG4105CZX twitching motility protein AL539_17490 ENOG4105DFA alanine racemase domain protein AL539_17495 ENOG4105II7 pyrroline-5-carboxylate reductase AL539_17500 ENOG4108VIA integral membrane protein AL539_17505 ENOG4105VZ9 UPF0235 protein AL539_17515 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL539_17520 ENOG4105CSA Coproporphyrinogen iii oxidase AL539_17525 ENOG4105CSV Glutaminase AL539_17535 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AL539_17540 ENOG4105CEN a g-specific adenine glycosylase AL539_17560 ENOG4105EUZ Beta-lactamase domain protein AL539_17570 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AL539_17580 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AL539_17675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL539_17685 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AL539_17695 ENOG4105CEN a g-specific adenine glycosylase AL539_17715 ENOG4105EUZ Beta-lactamase domain protein AL539_17725 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AL539_17820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL539_17830 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AL539_17845 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AL539_17890 ENOG4105C8Q Methyl-accepting chemotaxis AL539_17925 ENOG4105C26 Dehydrogenase AL539_17970 ENOG4108ESY Metal dependent phosphohydrolase AL539_17975 ENOG4105ETE Transcriptional regulator (LacI family AL539_17980 ENOG410901P UPF0249 protein AL539_17985 ENOG4105F8D glycoside hydrolase family 4 AL539_17990 ENOG4105VCP PTS System AL539_17995 ENOG4105CK1 PTS System AL539_18015 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL539_18020 ENOG4105EXU Membrane AL539_18030 ENOG4108K5H permease YjgP YjgQ family protein AL539_18035 ENOG4108M8S permease YjgP YjgQ family protein AL539_18040 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AL539_18045 ENOG4105MYG DNA polymerase iii, chi subunit AL539_18050 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AL539_18060 ENOG4108MJ3 acetyltransferase AL539_18075 ENOG4105CEU Arginine dihydrolase AL539_18080 ENOG4105DBV ornithine carbamoyltransferase AL539_18090 ENOG4105CXT aspartate transcarbamylase AL539_18095 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AL539_18100 ENOG4105KME endoribonuclease L-psp AL539_18105 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AL539_18110 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AL539_18115 ENOG4105VFK BolA family AL539_18125 ENOG4105E3I toluene tolerance AL539_18130 ENOG4107PE3 Mammalian cell entry related domain protein AL539_18135 ENOG4105CY3 ABC transporter, permease AL539_18140 ENOG4105DHJ ABC, transporter AL539_18150 ENOG4105C2X Arabinose 5-phosphate isomerase AL539_18160 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AL539_18165 ENOG4108IUZ ABC transporter AL539_18170 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL539_18175 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AL539_18180 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AL539_18185 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AL539_18190 ENOG41080Z8 PHOSPHOCARRIER protein AL539_18195 ENOG4105CJW magnesium transporter AL539_18200 ENOG4105CMS peptidase U62, modulator of DNA gyrase AL539_18205 ENOG4105N42 UPF0307 protein AL539_18210 ENOG4105C5I Dehydrogenase AL539_18215 ENOG4105D3G Pseudouridine synthase AL539_18220 ENOG4105K3M )-transporter AL539_18225 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AL539_18230 ENOG4108IAB Phoh family AL539_18235 ENOG4105D1U peptidase U62 modulator of DNA gyrase AL539_18245 ENOG4105QD6 exported protein AL539_18250 ENOG4105C03 ribonuclease AL539_18255 ENOG4108Z03 MAF-like protein AL539_18260 ENOG4105VQ7 Rod shape-determining protein MreD AL539_18265 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AL539_18270 ENOG4105DFF Rod shape-determining protein mreb AL539_18290 ENOG41062P1 Diguanylate cyclase phosphodiesterase AL539_18295 ENOG4108UUM single-stranded DNA-binding protein AL539_18300 ENOG41086KC Transcriptional regulator AL539_18305 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AL539_18310 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AL539_18320 ENOG4105C5R Aminotransferase AL539_18330 ENOG4105CFH Aspartokinase AL539_18335 ENOG4105C3R Methionine synthase AL539_18340 ENOG4105EEQ Na H antiporter AL539_18400 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AL539_18405 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AL539_18410 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AL539_18430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL539_18435 ENOG4105MYN Zinc uptake regulation protein AL539_18445 ENOG4107QP8 phosphohexose isomerase AL539_18450 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AL539_18455 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL539_18460 ENOG4105CDU Replicative dna helicase AL539_18470 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AL539_18475 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AL539_18480 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) AL539_18485 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AL539_18490 ENOG4105DJV ribulose-phosphate 3-epimerase AL539_18495 ENOG4105DFE Dna adenine methylase AL539_18505 ENOG4105D49 3-dehydroquinate synthase AL539_18510 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AL539_18515 ENOG4105E4G Type IV pilus AL539_18540 ENOG4108JQC penicillin-binding protein 1A AL539_18545 ENOG4105C5Q Transcriptional regulator AL539_18550 ENOG4105EHV domain protein AL539_18555 ENOG4107QN2 dihydrolipoyl dehydrogenase AL539_18565 ENOG4105CH7 arginosuccinase AL539_18570 ENOG4105CDH Citrulline--aspartate ligase AL539_18575 ENOG4105CAS nag kinase AL539_18580 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AL539_18585 ENOG4105CWC Acetylornithine deacetylase AL539_18590 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AL539_18600 ENOG4105SYT Methylenetetrahydrofolate reductase AL539_18605 ENOG4105CFH Aspartokinase AL539_18610 ENOG4105C28 cystathionine AL539_18615 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AL539_18620 ENOG4105C6K Malic enzyme AL539_18625 ENOG4108UQY Iron-storage protein AL539_18630 ENOG4105W53 bacterioferritin-associated ferredoxin AL539_18635 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL539_18640 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL539_18645 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AL539_18650 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AL539_18660 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AL539_18665 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AL539_18670 ENOG4105WWK YheO domain protein AL539_18675 ENOG4108V1T peptidylprolyl cis-trans isomerase AL539_18685 ENOG41069P5 Protein slyX homolog AL539_18690 ENOG4105D44 asparaginase AL539_18700 ENOG4108YZY peptidylprolyl cis-trans isomerase AL539_18715 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL539_18720 ENOG4105C5H ABC transporter AL539_18730 ENOG4105DNZ Alpha Beta Hydrolase AL539_18735 ENOG4105YP7 UPF0270 protein AL539_18740 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AL539_18745 ENOG4107RYR Transcriptional regulator, Crp Fnr family AL539_18755 ENOG4105C26 Dehydrogenase AL539_18765 ENOG4105C8Y Acetylornithine aminotransferase AL539_18770 ENOG4105DDQ anthranilate synthase AL539_18775 ENOG41067TZ transcriptional regulator, MarR family AL539_18780 ENOG4108KTG Membrane protein, drug metabolite transporter AL539_18790 ENOG4105CH2 amidohydrolase AL539_18795 ENOG4105CFC Transporter AL539_18800 ENOG4105DND Transcriptional regulator AL539_18815 ENOG4105C31 Tryptophanyl-tRNA synthetase AL539_18820 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL539_18825 ENOG4105C2N RNA methyltransferase TrmH family group 3 AL539_18830 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AL539_18835 ENOG4105KPV Transcriptional regulator AL539_18840 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL539_18845 ENOG4108UV7 flagellar protein motX AL539_18855 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL539_18865 ENOG4105EPW hflc protein AL539_18870 ENOG4107QJR hflk protein AL539_18875 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AL539_18880 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AL539_18885 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AL539_18890 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AL539_18895 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AL539_18900 ENOG4105K8N protein family UPF0079, ATPase AL539_18910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AL539_18975 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AL539_18980 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL539_18985 ENOG4105DJ4 phosphatidylserine decarboxylase AL539_19000 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AL539_19005 ENOG4107YZP Rhodanese domain protein AL539_19010 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AL539_19015 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AL539_19020 ENOG4105D7W serine acetyltransferase AL539_19025 ENOG41063SB peptidase AL539_19035 ENOG41062JF Transcriptional regulator AL539_19045 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AL539_19055 ENOG4105E33 succinate dehydrogenase AL539_19060 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL539_19065 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL539_19075 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AL539_19080 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AL539_19085 ENOG4105KT7 mgtC SapB transporter AL539_19095 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL539_19100 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL539_19105 ENOG4107QI1 Mate efflux family protein AL539_19110 ENOG4105CTQ phosphohexokinase AL539_19115 ENOG41076HS cation diffusion facilitator family transporter AL539_19120 ENOG4108SPG Periplasmic Protein AL539_19125 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL539_19130 ENOG4105E0F Histidine kinase AL539_19140 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AL539_19145 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 AL539_19150 ENOG4108IJ0 Aspartate ammonia-lyase AL539_19155 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL539_19160 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL539_19170 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AL539_19180 ENOG4107QN1 sodium solute AL539_19195 ENOG4105C9Q fumarate hydratase class II AL539_19200 ENOG4105BZU Histidine kinase AL539_19205 ENOG4105D8G Major Facilitator superfamily AL539_19220 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL539_19225 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AL539_19230 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AL539_19235 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AL539_19245 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AL539_19250 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL539_19255 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AL539_19265 ENOG4105C5H ABC transporter AL539_19330 ENOG4105CXN decarboxylase AL539_19335 ENOG4105D5Q Arginine ornithine antiporter AL539_19345 ENOG4108M3R transcriptional activator CadC AL539_19350 ENOG4105W1Y Transcriptional regulator AL539_19360 ENOG4105DC1 bifunctional purine biosynthesis protein purh AL539_19365 ENOG4105C12 Phosphoribosylglycinamide synthetase AL539_19385 ENOG4105R2J Conserved Protein AL539_19390 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AL539_19395 ENOG4108RG0 uracil-dna glycosylase AL539_19400 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AL539_19405 ENOG4105E09 nadh pyrophosphatase AL539_19410 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor AL539_19415 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL539_19420 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL539_19425 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AL539_19430 ENOG4108VZM 50s ribosomal protein L10 AL539_19435 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AL539_19440 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AL539_19445 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AL539_19450 ENOG4105PM1 preprotein translocase subunit SecE AL539_19460 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL539_19485 ENOG4105CS9 pantothenic acid kinase AL539_19490 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AL539_19495 ENOG4105D4A Cell wall formation (By similarity) AL539_19505 ENOG4105JIM Phosphatidylserine synthase AL539_19575 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AL539_19585 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AL539_19590 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AL539_19605 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AL539_19610 ENOG4107R73 Mate efflux family protein AL539_19625 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AL539_19635 ENOG4105E55 glycerol-3-phosphate acyltransferase AL539_19640 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AL539_19645 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AL539_19650 ENOG4105X6C Flagellar basal body-associated protein FliL AL539_19655 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AL539_19660 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL539_19670 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL539_19675 ENOG4105CRP Part of the ABC transporter FtsEX involved in AL539_19680 ENOG4105CAK Cell division ATP-binding protein ftsE AL539_19685 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AL539_19690 ENOG4106H78 methyltransferase AL539_19700 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AL539_19745 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL539_19750 ENOG41082YX Transcriptional regulator, arsr family AL539_19755 ENOG4105D58 Diguanylate phosphodiesterase AL539_19760 ENOG410829K Lysine exporter protein (Lyse ygga) AL539_19765 ENOG4108EUD Lysophospholipase AL539_19770 ENOG4105DQF Hydrolase AL539_19785 ENOG4106IUH DTW domain containing protein AL539_19790 ENOG4105BZU Histidine kinase AL539_19795 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AL539_19800 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL539_19810 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AL539_19815 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL539_19825 ENOG4105XQ6 frataxin-like protein AL539_19830 ENOG4107T0K Adenylate cyclase AL539_19835 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AL539_19840 ENOG41076E6 Uroporphyrinogen-III Synthase AL539_19845 ENOG4105ECF c-methyltransferase AL539_19850 ENOG410601J HemY protein AL539_19890 ENOG4107QK7 reductase AL539_19895 ENOG4108ZIT Ferredoxin, 2FE-2S AL539_19900 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AL539_19910 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AL539_19915 ENOG4105K63 Thioredoxin AL539_19920 ENOG4105C1J atp-dependent rna helicase AL539_19925 ENOG4105C9X ppx gppa phosphatase AL539_19935 ENOG4105EX9 Membrane AL539_19945 ENOG4105C9U ATP-dependent DNA helicase RecQ AL539_19950 ENOG4105FR1 rard protein AL539_19965 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL539_19975 ENOG4105C4R Atp-dependent dna helicase AL539_19985 ENOG4105E18 UPF0276 protein AL539_20015 ENOG4105DC7 peptidase M24 AL539_20015 ENOG4105DC7 peptidase M24 AL539_20020 ENOG4105D41 biosynthesis protein thiH AL539_20025 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AL539_20030 ENOG4105WHD thiamine biosynthesis protein ThiS AL539_20035 ENOG4105D06 uba thif-type nad fad binding protein AL539_20045 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AL539_20050 ENOG4105WMR Protein CrcB homolog AL539_20055 ENOG4105E3B Multicopper oxidase AL539_20185 ENOG4108Z0R Transferase AL539_20190 ENOG4105SG3 Protein of unknown function (DUF1488) AL539_20195 ENOG4105E2X shikimate dehydrogenase AL539_20200 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AL539_20205 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL539_20210 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AL539_20215 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AL539_20220 ENOG4108WI1 Dna topoisomerase AL539_20225 ENOG4108RPN Protein smg homolog AL539_20230 ENOG4105C79 DNA protecting protein DprA AL539_20240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL539_20245 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AL539_20250 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL539_20255 ENOG4105C1A potassium transporter peripheral membrane AL539_20260 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL539_20270 ENOG4108UT2 hemolysin iii AL539_20275 ENOG4108N23 SpoOM-related protein AL539_20285 ENOG4105PC1 Conserved Protein AL539_20295 ENOG4105E27 serine threonine protein kinase AL539_20300 ENOG4108Z33 Thiol disulfide Interchange Protein AL539_20305 ENOG4106HNH Acyl-transferase AL539_20315 ENOG4105C0P Mg chelatase subunit ChlI AL539_20325 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AL539_20330 ENOG4105CM2 brancheD-chain amino acid aminotransferase AL539_20335 ENOG4105C01 Dihydroxy-acid dehydratase AL539_20340 ENOG4105C7B Threonine dehydratase AL539_20345 ENOG4105F52 Transcriptional regulator AL539_20350 ENOG4105CZQ inner membrane transport protein YdhC AL539_20355 ENOG4105F87 Dehydratase AL539_20360 ENOG4105EAD ABC transporter AL539_20365 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AL539_20370 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AL539_20375 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AL539_20380 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AL539_20385 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AL539_20390 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL539_20400 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL539_20405 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AL539_20410 ENOG410684E atp synthase AL539_20415 ENOG4105FA0 parb-like partition protein AL539_20420 ENOG4107QJE Chromosome Partitioning Protein AL539_20425 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AL539_20430 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AL539_20440 ENOG4105QTB Flavodoxin AL539_20445 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AL539_20450 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AL539_20455 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AL539_20460 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AL539_20470 ENOG4105CDA abc transporter atp-binding protein AL539_20475 ENOG4105E5Q amino acid AbC transporter AL539_20480 ENOG4105EAB amino acid AbC transporter AL539_20490 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL539_20495 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AL539_20500 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AL539_20505 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL539_20525 ENOG4108ZNX Heat shock protein AL539_20530 ENOG4105JKW Valine--pyruvate aminotransferase AL539_20535 ENOG4107T9C Alpha amylase catalytic region AL539_20540 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AL539_20545 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AL539_20560 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AL539_20575 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AL539_20580 ENOG4105CHU acetyl-coa acetyltransferase AL539_20585 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL539_20590 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AL539_20595 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL539_20600 ENOG4108RR8 protoporphyrinogen oxidase AL539_20640 ENOG4105EMY transcriptional regulator AL539_20645 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AL539_20650 ENOG4105W0Z cytoplasmic protein AL539_20655 ENOG4105BZS acriflavin resistance protein AL539_20660 ENOG410624X efflux transporter, rnd family, mfp subunit AL539_20665 ENOG41067SE Tetr family transcriptional regulator AL539_20670 ENOG4105C4R Atp-dependent dna helicase AL539_20675 ENOG4105MPD Cytochrome AL539_20715 ENOG4108JQ6 ABC transporter AL539_20720 ENOG4107QSI ABC, transporter AL539_20725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL539_20730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL539_20745 ENOG4105DIQ Transcriptional regulator AL539_20750 ENOG41064T2 transcriptional regulator, lysR family AL539_20755 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AL539_20760 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) AL539_20765 ENOG4105C01 Dihydroxy-acid dehydratase AL539_20770 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AL539_20775 ENOG4105C6Z Gluconate AL539_20780 ENOG4108UHU Aldolase AL539_20785 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AL539_20790 ENOG4107RSM transcriptional regulator AL539_20795 ENOG4105DC8 reductase AL539_20800 ENOG4105D6S protein involved in catabolism of external DNA AL539_20805 ENOG4105DGW oligopeptidase A AL539_20810 ENOG4108VVK transcriptional Regulator, AsnC AL539_20815 ENOG4105BZU Histidine kinase AL539_20820 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AL539_20830 ENOG4105EMK carboxylate amino acid amine transporter AL539_20835 ENOG4108M6U Universal stress protein A AL539_20840 ENOG41090A1 ferritin AL539_20845 ENOG4108V6B universal stress protein B AL539_20850 ENOG4105CBX hi0933 family AL539_20855 ENOG4108JUA Transcriptional regulator AL539_20880 ENOG4107TE5 Lipid kinase AL539_20910 ENOG4105DSF transport protein AL539_20915 ENOG4105BZU Histidine kinase AL539_20925 ENOG4105CGY Dna recombination protein AL539_20930 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AL539_20935 ENOG4105JC1 sterol-binding domain protein AL539_20940 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL539_20945 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AL539_20950 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AL539_20955 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AL539_20970 ENOG4105F8V Hydrolase, tatD family AL539_20980 ENOG4105D52 delta-aminolevulinic acid dehydratase AL539_20985 ENOG4105KD7 acetyltransferase AL539_20995 ENOG4105C2M dna polymerase I AL539_21000 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AL539_21005 ENOG4106RE7 Cytochrome AL539_21020 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AL539_21025 ENOG4105XCT Protein of unknown function (DUF2489) AL539_21030 ENOG4105D4P Coproporphyrinogen iii oxidase AL539_21035 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL539_21040 ENOG4105BZU Histidine kinase AL539_21045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_21050 ENOG4105CUX Signal transduction histidine kinase AL539_21060 ENOG4105C5F glutamine synthetase AL539_21070 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL539_21080 ENOG4107S2Z UPF0761 membrane protein AL539_21085 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AL539_21090 ENOG4105SUU thioesterase domain AL539_21100 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AL539_21105 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AL539_21110 ENOG4105VEJ Heat shock protein AL539_21115 ENOG4108XKW General secretion pathway protein C AL539_21125 ENOG4107QHF type ii secretion system protein e AL539_21130 ENOG4105D7Q type ii secretion system AL539_21135 ENOG4108VAU general secretion pathway protein G AL539_21140 ENOG4105VWV general secretion pathway protein h AL539_21145 ENOG4105X5Z General secretion pathway protein I AL539_21150 ENOG4108WWZ General secretion pathway protein J AL539_21155 ENOG4108RTD type II secretion system protein K AL539_21160 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) AL539_21165 ENOG4105U1E general secretion pathway protein M AL539_21170 ENOG4105PIC general secretion pathway protein N AL539_21180 ENOG4107RK2 ADP-ribose diphosphatase NudE AL539_21185 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AL539_21190 ENOG4105MJ2 Competence protein AL539_21195 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL539_21205 ENOG4105BZM domain protein AL539_21215 ENOG4108RRZ Transcription elongation factor GreB AL539_21225 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL539_21230 ENOG4105E0F Histidine kinase AL539_21235 ENOG4105C2W permease AL539_21240 ENOG4105CB5 ATP-dependent DNA helicase recG AL539_21245 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AL539_21250 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL539_21255 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AL539_21260 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AL539_21280 ENOG4109015 Biopolymer transport protein exbD tolR AL539_21310 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AL539_21315 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AL539_21320 ENOG4107QRA Extracellular solute-binding protein, family 5 AL539_21330 ENOG4108JQ7 (ABC) transporter AL539_21340 ENOG4105DSJ YicC domain protein AL539_21350 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AL539_21355 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AL539_21360 ENOG4105D1S lipid A biosynthesis AL539_21365 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AL539_21370 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AL539_21380 ENOG4105C8Q Methyl-accepting chemotaxis AL539_21385 ENOG4105W5Q DNA repair protein (RadC AL539_21390 ENOG4105KDC 50s ribosomal protein l28 AL539_21405 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AL539_21420 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AL539_21425 ENOG4108JMC lipopolysaccharide core biosynthesis protein AL539_21430 ENOG4105DKP glycosyl transferase, family 9 AL539_21435 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AL539_21440 ENOG41080IJ Diacylglycerol kinase AL539_21445 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) AL539_21450 ENOG4105C1B dTDP-glucose 4-6-dehydratase AL539_21455 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AL539_21465 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AL539_21480 ENOG4108UT6 Transferase hexapeptide repeat containing protein AL539_21490 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AL539_21495 ENOG4105XA0 heptosyltransferase ii AL539_21500 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AL539_21505 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AL539_21510 ENOG4105E3R (LipO)protein AL539_21545 ENOG4105C1B dTDP-glucose 4-6-dehydratase AL539_21550 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AL539_21560 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AL539_21565 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase AL539_21580 ENOG41066H3 AL539_21590 ENOG4108SHN Glycosyl transferase, family 2 AL539_21600 ENOG4105D3Q Sugar transferase AL539_21605 ENOG4105EQK -acetyltransferase AL539_21610 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AL539_21625 ENOG4105CY0 Metallo-Beta-Lactamase AL539_21635 ENOG4105CP7 Triose-phosphate isomerase AL539_21660 ENOG4105CBT Fructose-1,6-bisphosphatase AL539_21665 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AL539_21670 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL539_21675 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AL539_21705 ENOG4108YGG dna repair protein AL539_21715 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AL539_21720 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AL539_21730 ENOG4105ETE Transcriptional regulator (LacI family AL539_21735 ENOG4105C25 Primosomal protein n' AL539_21745 ENOG4105VFB Binds the 23S rRNA (By similarity) AL539_21750 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AL539_21755 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AL539_21760 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AL539_21765 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AL539_21770 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AL539_21775 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AL539_21780 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AL539_21785 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AL539_21790 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AL539_21795 ENOG41083MP 50s ribosomal protein l29 AL539_21800 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AL539_21805 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AL539_21810 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AL539_21815 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AL539_21820 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AL539_21825 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AL539_21830 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AL539_21840 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AL539_21845 ENOG4105VPB 50S ribosomal protein L30 AL539_21850 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AL539_21855 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AL539_21865 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AL539_21870 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AL539_21875 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AL539_21880 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL539_21885 ENOG4108ZT0 50S ribosomal protein l17 AL539_21895 ENOG4108V1T peptidylprolyl cis-trans isomerase AL539_21905 ENOG4107YB6 acetyltransferase, (GNAT) family AL539_21910 ENOG4105C1J atp-dependent rna helicase AL539_21920 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AL539_21925 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL539_21930 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AL539_21935 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AL539_21945 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AL539_21965 ENOG4108I0Y (ABC) transporter AL539_21980 ENOG4108UUE Transcriptional regulator AL539_21985 ENOG41061GZ Protein of unknown function (DUF1107) AL539_21990 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL539_21995 ENOG4105CFU surface antigen AL539_22000 ENOG4105MA0 exported protein AL539_22005 ENOG41066HZ AIG2-like family AL539_22025 ENOG4107RK6 Methyl-accepting chemotaxis AL539_22060 ENOG4105F0N pyrophosphate phospho-hydrolase AL539_22065 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AL539_22075 ENOG4105DFU Cell wall formation (By similarity) AL539_22080 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AL539_22085 ENOG4105DP9 ABC transporter AL539_22090 ENOG4106SMU thiamine transporter membrane protein AL539_22095 ENOG4107T0D ABC, transporter AL539_22100 ENOG4105CC0 LysR family Transcriptional regulator AL539_22105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL539_22135 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AL539_22140 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AL539_22150 ENOG4105EAH synthase AL539_22155 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AL539_22160 ENOG4105K46 50S ribosomal protein l27 AL539_22165 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AL539_22170 ENOG4105DWK Membrane AL539_22175 ENOG4107XM3 UPF0442 protein AL539_22180 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AL539_22185 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AL539_22190 ENOG4105NWN ApaG protein AL539_22195 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AL539_22200 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AL539_22205 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AL539_22210 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AL539_22215 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AL539_22225 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL539_22230 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL539_22235 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AL539_22240 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AL539_22265 ENOG41064T2 transcriptional regulator, lysR family AL539_22270 ENOG4108IQE Amp-dependent synthetase and ligase AL539_22275 ENOG4105C7K acetolactate synthase AL539_22280 ENOG4108ZP8 Acetolactate synthase small subunit AL539_22285 ENOG4105BZU Histidine kinase AL539_22295 ENOG4105CA9 Pyruvate kinase AL539_22300 ENOG410804X Transcriptional regulator AL539_22305 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AL539_22340 ENOG4107QTH restriction modification system DNA specificity domain AL539_22365 ENOG4105CMT Dihydroxyacetone kinase AL539_22370 ENOG4108UTZ Dihydroxyacetone kinase AL539_22385 ENOG4105E61 Mannitol repressor protein AL539_22390 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AL539_22395 ENOG4105CTS PTS system mannitol-specific AL539_22415 ENOG4105D01 (LipO)protein AL539_22435 ENOG4105VEQ Cold shock protein AL539_22460 ENOG4105CAF HipA N-terminal domain protein AL539_22490 ENOG4105ENA helicase AL539_22510 ENOG4105CAF HipA N-terminal domain protein AL539_22525 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL539_22530 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AL539_22535 ENOG4105KTH gatB Yqey AL539_22540 ENOG4105VCC 30S ribosomal protein S21 AL539_22545 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL539_22550 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AL539_22555 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AL539_22560 ENOG4107ZVW dihydroneopterin aldolase AL539_22565 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL539_22570 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AL539_22575 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AL539_22590 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL539_22595 ENOG4106MWK domain protein AL539_22600 ENOG4105CJ3 phosphate transporter AL539_22605 ENOG4107IX6 phosphate transport regulator AL539_22610 ENOG4105I7R Adenylate cyclase AL539_22620 ENOG4105C8Q Methyl-accepting chemotaxis AL539_22625 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AL539_22630 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AL539_22635 ENOG4105DFG type I secretion outer membrane protein AL539_22640 ENOG41087AY ADP-Ribose pyrophosphatase AL539_22645 ENOG4108SX3 cytoplasmic protein AL539_22650 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AL539_22655 ENOG4105IPS esterase AL539_22660 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL539_22665 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL539_22670 ENOG4105C0H protease AL539_22675 ENOG4105C0H protease AL539_22680 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AL539_22690 ENOG4105D6Z AFG1 family ATPase AL539_22700 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AL539_22705 ENOG4108UJD 30S ribosomal protein S9 AL539_22710 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL539_22715 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL539_22720 ENOG4105EIX cytochrome c1 AL539_22725 ENOG4107MKT Stringent starvation protein a AL539_22730 ENOG4105KB2 stringent starvation protein b AL539_22735 ENOG4105W4M Transport-associated protein AL539_22740 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL539_22745 ENOG41082RQ UPF0102 protein AL539_22755 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AL539_22770 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AL539_22775 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL539_22780 ENOG4105CJN penicillin-binding protein AL539_22785 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AL539_22790 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AL539_22795 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AL539_22800 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AL539_22810 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AL539_22815 ENOG4105DFU Cell wall formation (By similarity) AL539_22820 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AL539_22825 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AL539_22830 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AL539_22835 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL539_22845 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL539_22850 ENOG4105M6F mutator MutT protein AL539_22855 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AL539_22860 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AL539_22865 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AL539_22880 ENOG4105EJ9 Membrane AL539_22885 ENOG4105VP0 transcriptional regulator, lysR family AL539_22890 ENOG4105EN6 Membrane AL539_22895 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AL539_22900 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AL539_22905 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AL539_22915 ENOG4105BZ8 glutamate synthase AL539_22920 ENOG4105CBC glutamate synthase AL539_22935 ENOG4105N5T Radical SAM Protein AL539_22945 ENOG4105BZU Histidine kinase AL539_22955 ENOG41065U4 response regulator AL539_22970 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL539_22990 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AL539_22995 ENOG4105D98 threonine synthase AL539_23005 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) AL539_23010 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AL539_23020 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AL539_23035 ENOG4105BZG amino acid carrier protein AL539_23040 ENOG4105D1Q UPF0246 protein AL539_23045 ENOG4105C1J atp-dependent rna helicase AL539_23050 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AL539_23055 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL539_23060 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AL539_23065 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL539_23070 ENOG4105T95 Thiol disulfide interChange protein AL539_23075 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AL539_23085 ENOG4105CRK lysyL-tRNA synthetase AL539_23090 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_23100 ENOG4105CPC Aldo Keto reductase AL539_23110 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) AL539_23115 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AL539_23120 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AL539_23125 ENOG4105HF0 Membrane AL539_23130 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AL539_23135 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AL539_23150 ENOG41063Z6 transcriptional regulator, lysR family AL539_23155 ENOG41080HT Transcriptional regulator, arsr family AL539_23160 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AL539_23165 ENOG4105CJR Integral membrane protein (MviN AL539_23170 ENOG4105DTN riboflavin biosynthesis protein ribF AL539_23175 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL539_23180 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AL539_23185 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AL539_23190 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AL539_23200 ENOG4108NEV two component transcriptional regulator, LytTR family AL539_23205 ENOG4108HRK Histidine kinase AL539_23225 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL539_23230 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AL539_23235 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AL539_23240 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL539_23245 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AL539_23250 ENOG4105DR5 peptidase AL539_23260 ENOG4105C5H ABC transporter AL539_23265 ENOG4107SC1 transglycosylase AL539_23270 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) AL539_23275 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL539_23285 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AL539_23295 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL539_23300 ENOG4105C34 Pseudouridine synthase AL539_23305 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AL539_23310 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL539_23375 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AL539_23380 ENOG4105CFP Peptidase U32 AL539_23385 ENOG4105DH7 May be involved in recombination (By similarity) AL539_23395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL539_23400 ENOG4105BZU Histidine kinase AL539_23410 ENOG4105C9X ppx gppa phosphatase AL539_23415 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AL539_23420 ENOG4105C8U phosphate abc transporter AL539_23425 ENOG4105E2Z phosphate ABC transporter (Permease AL539_23430 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL539_23440 ENOG4105CSR polyphosphate kinase 2 AL539_23445 ENOG4106N3A copper homeostasis protein cutc AL539_23450 ENOG4105D3R alkyl hydroperoxide reductase AL539_23455 ENOG4105C5Q Transcriptional regulator AL539_23460 ENOG4107QP3 malate synthase g AL539_23465 ENOG4108I9X Isocitrate lyase AL539_23470 ENOG4105W87 Cbs domain AL539_23480 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AL539_23485 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AL539_23490 ENOG4105VIE preprotein translocase, subunit YajC AL539_23495 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL539_23500 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL539_23515 ENOG4105ECY inositol monophosphatase AL539_23520 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AL539_23525 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AL539_23530 ENOG4105C3J Cysteine desulfurase AL539_23535 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AL539_23540 ENOG4108Z4V iron-sulfur cluster assembly AL539_23545 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AL539_23550 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AL539_23555 ENOG4108ZIT Ferredoxin, 2FE-2S AL539_23560 ENOG4105WVQ Fe-S assembly protein IscX AL539_23565 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AL539_23570 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AL539_23575 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AL539_23585 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AL539_23590 ENOG4105CUT histidyl-tRNA synthetase AL539_23595 ENOG4105N21 Membrane AL539_23600 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL539_23605 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AL539_23620 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL539_23625 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL539_23630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL539_23635 ENOG4107S6Z Na H antiporter AL539_23645 ENOG4106HK8 GPR1 FUN34 yaaH family protein AL539_23650 ENOG4105BZG amino acid carrier protein AL539_23655 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL539_23665 ENOG4108IQK o-acetylhomoserine AL539_23670 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL539_23690 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AL539_23695 ENOG4105ETT transcriptional Regulator, LysR family AL539_23740 ENOG4105BZU Histidine kinase AL539_23745 ENOG4105BZU Histidine kinase AL539_23775 ENOG4105BZU Histidine kinase AL539_23795 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL539_23815 ENOG4105CAF HipA N-terminal domain protein AL539_23885 ENOG4105DZR Type I site-specific deoxyribonuclease AL539_23890 ENOG4105EKX Restriction modification system DNA (Specificity AL539_23930 ENOG4105DFP Integrase AL539_23940 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AL539_23945 ENOG4108Z1B Cyclase dehydrase AL539_23950 ENOG4105VDB UPF0125 protein AL539_23955 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL539_23965 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AL539_23975 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AL539_23980 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AL539_23985 ENOG4105CK2 sodium dicarboxylate symporter AL539_23990 ENOG4105CFG Acts as a chaperone (By similarity) AL539_23995 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AL539_24025 ENOG4105CFC Transporter AL539_24030 ENOG4108Z6B deaminase AL539_24040 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AL539_24045 ENOG4108ETH Formylglycinamide ribotide synthetase AL539_24060 ENOG4105X58 receptor AL539_24075 ENOG4105CIN aminoacyl-histidine dipeptidase AL539_24080 ENOG4105C7N Xanthine uracil vitamin C permease AL539_24085 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AL539_24090 ENOG4108DJV Fermentation respiration switch protein AL539_24095 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AL539_24100 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AL539_24105 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AL539_24110 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AL539_24115 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL539_24130 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AL539_24135 ENOG4107YIM Involved in the transcription termination process (By similarity) AL539_24140 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AL539_24145 ENOG4108ZAI phosphatidylglycerophosphatase a AL539_24150 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AL539_24155 ENOG4105CTB Polyprenyl synthetase AL539_24160 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL539_24165 ENOG4105E14 MotA TolQ exbB proton channel AL539_24170 ENOG4106VK6 Flagellar motor protein AL539_24175 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AL539_24180 ENOG4105ETT transcriptional Regulator, LysR family AL539_24190 ENOG4105M08 Membrane AL539_24195 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AL539_24200 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease AL539_24205 ENOG4105EWT decarboxylase family AL539_24210 ENOG4105BZU Histidine kinase AL539_24220 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AL539_24225 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AL539_24230 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein AL539_24235 ENOG4105D01 (LipO)protein AL539_24240 ENOG4108UMI ABC transporter, permease AL539_24245 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AL539_24250 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AL539_24255 ENOG4105D4X repressor AL539_24260 ENOG4105C5Y PTS System AL539_24265 ENOG4105CG3 alpha amylase, catalytic region AL539_24280 ENOG4108JYZ YitT family AL539_24285 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL539_24290 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AL539_24295 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AL539_24300 ENOG4108Z43 UPF0250 protein AL539_24305 ENOG4105DZ1 carboxypeptidase AL539_24310 ENOG4105K6T rare lipoprotein A AL539_24315 ENOG4105CNI cell division protein FtsW AL539_24320 ENOG4105CJN penicillin-binding protein AL539_24325 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AL539_24330 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AL539_24335 ENOG4105DJF DNA polymerase III, delta' subunit AL539_24340 ENOG4108U2H Rare lipoprotein B AL539_24345 ENOG4105C8T Leucyl-tRNA synthetase AL539_24350 ENOG4107PAI alpha helical protein AL539_24355 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AL539_24360 ENOG4108JU5 Magnesium and cobalt efflux protein AL539_24365 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AL539_24370 ENOG4105C9A Phoh family AL539_24375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AL539_24385 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL539_24495 ENOG4105C3G gtp-binding protein AL539_24500 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AL539_24505 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AL539_24510 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AL539_24515 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AL539_24520 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AL539_24525 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AL539_24530 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AL539_24535 ENOG4108YY7 Invasion gene expression up-regulator SirB AL539_24540 ENOG41063JG Transcriptional regulator AL539_24545 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AL539_24550 ENOG4105CGH 5'-nucleotidase AL539_24555 ENOG4108Z66 YbaK ebsC protein AL539_24560 ENOG4105FE9 pseudouridine synthase AL539_24565 ENOG4108DG9 Smr protein MutS2 AL539_24590 ENOG4105E2D ec 3.2.1.52 AL539_24605 ENOG4105C59 p-type ATPase AL539_24615 ENOG41081QG Porin Gram-negative type AL539_24625 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AL539_24630 ENOG4105UYK outer membrane protein a AL539_24675 ENOG4107R88 Chemotaxis protein (CheV) AL539_24680 ENOG4105BZU Histidine kinase AL539_24685 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL539_24690 ENOG4108ZC9 flagellar basal-body rod protein flgc AL539_24695 ENOG4105W00 Flagellar hook capping protein AL539_24700 ENOG4105BZE flagellar hook protein, FlgE AL539_24705 ENOG4108KPB Flagellar basal-body rod protein FlgF AL539_24710 ENOG4105CGA flagellar basal-body rod protein FlgG AL539_24715 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL539_24720 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL539_24725 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL539_24735 ENOG4105DTJ flagellar hook-associated protein AL539_24740 ENOG4105I03 Flagellin AL539_24750 ENOG4105I03 Flagellin AL539_24760 ENOG4105C5Y PTS System AL539_24765 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AL539_24770 ENOG4105KZ7 phosphocarrier protein hpr AL539_24780 ENOG4105C6T cysteine synthase AL539_24785 ENOG4105EXN Sulfate transport protein CysZ AL539_24790 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AL539_24795 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AL539_24815 ENOG4107QX8 SPFH domain, Band 7 family protein AL539_24820 ENOG4107QR8 Thioredoxin AL539_24830 ENOG4105E1F short-chain dehydrogenase reductase AL539_24835 ENOG4105ECP epimerase AL539_24865 ENOG4108RE9 Phosphodiesterase AL539_24885 ENOG4108DQ1 activator toxR AL539_24890 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AL539_24895 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AL539_24900 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AL539_24905 ENOG4105DUX Transporter AL539_24910 ENOG4105MDZ Transcriptional activator rfaH AL539_24915 ENOG4105CAQ asparagine synthetase AL539_24920 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL539_24925 ENOG4105E2R ROK family AL539_24930 ENOG4105CE4 GlcNAc 6-P deacetylase AL539_24940 ENOG4105CI1 PTS System AL539_24945 ENOG4105CX6 glutaminyL-tRNA synthetase AL539_24950 ENOG41090R7 Ferric uptake AL539_24960 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AL539_24970 ENOG4105EV9 Alpha Beta Hydrolase AL539_24975 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AL539_24980 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AL539_24990 ENOG4107QNR UPF0135 protein AL539_24995 ENOG4105BZN citrate synthase AL539_25000 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AL539_25005 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AL539_25010 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AL539_25015 ENOG4105E33 succinate dehydrogenase AL539_25020 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AL539_25025 ENOG4105C7S Dehydrogenase AL539_25030 ENOG4105CMV Succinyl-CoA synthetase subunit beta AL539_25035 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AL539_25040 ENOG4105FAV ABC, transporter AL539_25045 ENOG4105FDK ABC transporter AL539_25050 ENOG4105NXV High-affinity zinc uptake system protein AL539_25060 ENOG4105XFK Ferrous iron transport protein A AL539_25085 ENOG4105C75 arginyL-tRNA synthetase AL539_25095 ENOG4106ZCM YecM protein AL539_25100 ENOG4105CIY formyltetrahydrofolate deformylase AL539_25105 ENOG4105DVT helicase AL539_25110 ENOG41072GX Peptidase M22 Glycoprotease AL539_25125 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL539_25130 ENOG4105CEY Amp-dependent synthetase and ligase AL539_25135 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AL539_25140 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AL539_25145 ENOG4107QMS site-determining protein AL539_25150 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AL539_25155 ENOG4105VNG YcgL domain-containing protein AL539_25160 ENOG4105CVE Lytic murein transglycosylase AL539_25170 ENOG4105D9N nucleoside AL539_25175 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AL539_25185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL539_25190 ENOG4105C2D reductase AL539_25195 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL539_25200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL539_25225 ENOG4105C84 Histidine ammonia-lyase AL539_25230 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AL539_25235 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL539_25255 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL539_25290 ENOG4105C1J atp-dependent rna helicase AL539_25295 ENOG4107ZYR domain protein AL539_25315 ENOG4105CNG UPF0061 protein AL539_25320 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL539_25325 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ AL539_25330 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL539_25340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL539_25345 ENOG4105CQZ Histidine kinase AL539_25355 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AL539_25360 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AL539_25365 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AL539_25370 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AL539_25375 ENOG4105K70 DNA-binding protein AL539_25380 ENOG4105EIN peptidylprolyl cis-trans isomerase AL539_25385 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AL539_25400 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AL539_25405 ENOG4105DK2 UPF0207 protein AL539_25410 ENOG4105CHM Aminotransferase AL539_25415 ENOG4105E4F Isochorismate synthase AL539_25420 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AL539_25430 ENOG4108IPT Naphthoate synthase AL539_25435 ENOG4105DNI Converts SHCHC to OSB (By similarity) AL539_25440 ENOG4105CEY Amp-dependent synthetase and ligase AL539_25450 ENOG4105HMI Membrane AL539_25455 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL539_25505 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AL539_25510 ENOG4105BZS acriflavin resistance protein AL539_25525 ENOG4105C6T cysteine synthase AL539_25530 ENOG4108XM1 transcriptional regulator AsnC family AL539_25540 ENOG4105C29 acyl-CoA thioesterase AL539_25545 ENOG4108MNP Glycoprotein polysaccharide metabolism AL539_25560 ENOG4105BZU Histidine kinase AL539_25575 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL539_25585 ENOG4107SXA Phosphorylase AL539_25595 ENOG4108NVR Methyl-accepting chemotaxis AL539_25600 ENOG4105K59 histidine triad (HIT) protein AL539_25625 ENOG4105D0Y UPF0227 protein AL539_25630 ENOG4105CEP NADH dehydrogenase AL539_25645 ENOG4108JA2 transcriptioN-repair coupling factor AL539_25655 ENOG4105D60 lipoprotein releasing system transmembrane protein AL539_25660 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AL539_25665 ENOG4105D60 lipoprotein releasing system transmembrane protein AL539_25675 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AL539_25680 ENOG4105BZ1 (ABC) transporter AL539_25685 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AL539_25690 ENOG4105W49 UPF0434 protein AL539_25695 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AL539_25700 ENOG4105ED1 spovr family AL539_25705 ENOG4106AKX UPF0229 protein AL539_25710 ENOG4105CYN Serine protein kinase AL539_25720 ENOG4105XWI UPF0304 protein AL539_25730 ENOG4105F1A Pyruvate formate-lyase AL539_25740 ENOG4105C6N Formate acetyltransferase AL539_25760 ENOG4108JEH abc transporter atp-binding protein AL539_25765 ENOG4105E89 ABC transporter AL539_25770 ENOG4105DSP amino acid AbC transporter AL539_25785 ENOG4105CGK Exodeoxyribonuclease III AL539_25790 ENOG4106428 Protein of unknown function (DUF2496) AL539_25795 ENOG4108URS primosomal replication protein n'' AL539_25800 ENOG4105EJ9 Membrane AL539_25805 ENOG4105DVT helicase AL539_25810 ENOG4105SDR Outer membrane protein OmpT AL539_25820 ENOG4108R99 pseudouridine synthase AL539_25830 ENOG4105VEQ Cold shock protein AL539_25835 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AL539_25840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL539_25845 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AL539_25850 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AL539_25855 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AL539_25865 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AL539_25870 ENOG4105RKX Protein of unknown function (DUF2498) AL539_25875 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL539_25880 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL539_25885 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AL539_25905 ENOG4105HP8 regulator of competence-specific genes AL539_25910 ENOG4105ETE Transcriptional regulator (LacI family AL539_25915 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL539_25920 ENOG4106WF9 DNA-binding transcriptional regulator TorR AL539_25925 ENOG4107S90 membrAne AL539_25930 ENOG4106371 Methyltransferase AL539_25935 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) AL539_25940 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AL539_25945 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AL539_25965 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL539_25975 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AL539_25980 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AL539_25985 ENOG41081XQ Conserved Protein AL539_25990 ENOG4105C9M aspartyl-trna synthetase AL539_25995 ENOG4105CDY transcriptional regulatory protein AL539_26000 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AL539_26005 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AL539_26010 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AL539_26015 ENOG4105C4M (Ubiquinol oxidase) subunit I AL539_26020 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL539_26035 ENOG4107YD3 Thioesterase AL539_26040 ENOG4105E02 MotA TolQ exbB proton channel AL539_26045 ENOG4105M8F Biopolymer transport protein exbD tolR AL539_26055 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AL539_26060 ENOG4105KCK Peptidoglycan-associated lipoprotein AL539_26065 ENOG4105UFD tol-pal system protein YbgF AL539_26070 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AL539_26080 ENOG4105Z6B inner membrane protein yjfl AL539_26090 ENOG4106032 Glutathionylspermidine synthase