locus-tag class description AL541_00005 ENOG4108HK0 -acetyltransferase AL541_00015 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL541_00025 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL541_00040 ENOG4105C5H ABC transporter AL541_00045 ENOG4108M6U Universal stress protein A AL541_00050 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL541_00055 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL541_00075 ENOG4105VUF Transcriptional regulator AL541_00080 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AL541_00090 ENOG4105KXC Collagenase AL541_00105 ENOG4105CR8 Transcriptional regulator AL541_00110 ENOG4105C8Q Methyl-accepting chemotaxis AL541_00120 ENOG41061MD high-affinity nickel-transporter AL541_00125 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter AL541_00130 ENOG4105C6Z Gluconate AL541_00135 ENOG4105EXW epimerase dehydratase AL541_00140 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AL541_00145 ENOG4105FB2 class II Aldolase AL541_00150 ENOG4105G63 Type III effector Hrp-dependent AL541_00155 ENOG4105ZXK Dehydrogenase AL541_00160 ENOG4105MVE transcriptional regulator AL541_00170 ENOG4105DEF Extracellular solute-binding protein, family 5 AL541_00175 ENOG4108JQ7 (ABC) transporter AL541_00180 ENOG4105C3U ABC transporter AL541_00185 ENOG4107R73 Mate efflux family protein AL541_00190 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AL541_00195 ENOG4107R88 Chemotaxis protein (CheV) AL541_00205 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related AL541_00210 ENOG41090JE Utilization Protein AL541_00215 ENOG4105D4P Coproporphyrinogen iii oxidase AL541_00220 ENOG4105WQ5 TonB family AL541_00225 ENOG41090AP transport protein AL541_00230 ENOG4106GFD transport protein AL541_00240 ENOG4105EHG Permease protein AL541_00245 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AL541_00285 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AL541_00290 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AL541_00295 ENOG4105QVC MOSC domain-containing protein AL541_00295 ENOG4105QVC MOSC domain-containing protein AL541_00310 ENOG4105EKE dihydroorotase AL541_00315 ENOG4105CKW Inner membrane protein yedI AL541_00345 ENOG4108JJ8 (ABC) transporter AL541_00375 ENOG4105EG2 ABC transporter, permease AL541_00380 ENOG4105D56 permease protein AL541_00385 ENOG4107FKK extracellular solute-binding protein family 1 AL541_00390 ENOG4108IJ9 (ABC) transporter AL541_00395 ENOG4105D3Q Sugar transferase AL541_00410 ENOG4108F2G Chain length determinant protein AL541_00450 ENOG4105V0I UPF0267 protein AL541_00455 ENOG4108WUH Transcriptional regulator, TetR family AL541_00460 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AL541_00465 ENOG4108RXX maleylacetoacetate isomerase AL541_00470 ENOG4105CH6 catalase AL541_00475 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL541_00505 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AL541_00520 ENOG4105CJP fad dependent oxidoreductase AL541_00525 ENOG4107QZF nitrite reductase NADPH large subunit AL541_00530 ENOG4105C26 Dehydrogenase AL541_00535 ENOG4105DVW rieske (2Fe-2S) AL541_00545 ENOG4105ETT transcriptional Regulator, LysR family AL541_00550 ENOG4105CZN Potassium uptake protein AL541_00565 ENOG4105BZU Histidine kinase AL541_00570 ENOG4105BZ1 (ABC) transporter AL541_00575 ENOG4105E0K tonB-dependent siderophore receptor AL541_00580 ENOG4105E0A ABC, transporter AL541_00585 ENOG4108HUF Transporter AL541_00590 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL541_00605 ENOG4108JJ6 Type I secretion system ATPase AL541_00615 ENOG41086KC Transcriptional regulator AL541_00620 ENOG41086KC Transcriptional regulator AL541_00630 ENOG4105C8Q Methyl-accepting chemotaxis AL541_00635 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL541_00670 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL541_00675 ENOG4105E2Z phosphate ABC transporter (Permease AL541_00680 ENOG4105C8U phosphate abc transporter AL541_00685 ENOG4107S17 Phosphate-binding protein AL541_00690 ENOG4108NVR Methyl-accepting chemotaxis AL541_00710 ENOG4107ENK receptor AL541_00715 ENOG4105CUG Oligopeptidase b AL541_00720 ENOG4105C1J atp-dependent rna helicase AL541_00730 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AL541_00735 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL541_00740 ENOG4108XDN Transcriptional regulator AL541_00745 ENOG4107SEY Conserved Protein AL541_00750 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL541_00765 ENOG4106TD9 Diguanylate cyclase AL541_00770 ENOG4105KK7 inner membrane protein YiaW AL541_00775 ENOG4105EFX secretion protein, HlyD family AL541_00780 ENOG4108V7D UPF0397 protein AL541_00785 ENOG4108JJB ABC transporter AL541_00805 ENOG4105GXZ Ferredoxin-type protein NapH AL541_00810 ENOG4108BGM Quinol dehydrogenase periplasmic component AL541_00815 ENOG4105WCN acetyltransferase AL541_00830 ENOG4105YE1 PilZ domain AL541_00835 ENOG4107QE9 Inherit from COG: Membrane AL541_00840 ENOG4105C8Q Methyl-accepting chemotaxis AL541_00845 ENOG4105DAN ATP-dependent protease AL541_00855 ENOG4108JQ5 ABC transporter AL541_00865 ENOG410642W LysR family Transcriptional regulator AL541_00870 ENOG4105DAA L-lactate AL541_00875 ENOG4105DMF Dehydrogenase AL541_00885 ENOG4105D64 Mechanosensitive ion channel AL541_00920 ENOG4105CPQ Dehydrogenase AL541_00925 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL541_00930 ENOG4105BZU Histidine kinase AL541_00945 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL541_00955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL541_00975 ENOG4105EXG Transcriptional regulator AL541_00980 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AL541_01000 ENOG4107SSZ Phosphatase AL541_01030 ENOG4108JIR Flagellum-specific ATP synthase AL541_01040 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL541_01045 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL541_01055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_01070 ENOG4105DD5 Flagellar motor switch protein AL541_01075 ENOG4105CN7 Flagellar biosynthetic protein FliP AL541_01080 ENOG4105VS8 Flagellar biosynthetic protein fliq AL541_01085 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL541_01090 ENOG4105D00 flagellar biosynthetic protein flhB AL541_01105 ENOG4105I03 Flagellin AL541_01115 ENOG410804A Flagellar hook-associated 2 domain-containing protein AL541_01120 ENOG4105MQ3 flagellar protein FliS AL541_01145 ENOG4107RD7 Flagellar Motor Protein, MotA AL541_01150 ENOG4105ER2 Ompa motb domain protein AL541_01165 ENOG4105KWG Pfam:DUF1696 AL541_01185 ENOG4105C6N Formate acetyltransferase AL541_01190 ENOG4105F1A Pyruvate formate-lyase AL541_01195 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL541_01215 ENOG4105EB3 Histidine kinase AL541_01220 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL541_01245 ENOG4105CNH Multidrug resistance protein MdtL AL541_01250 ENOG4105G2Y Transcriptional regulator AL541_01290 ENOG4105IPI Membrane AL541_01295 ENOG41068P6 UPF0319 protein AL541_01305 ENOG4105DP0 ferredoxin-NADP reductase AL541_01315 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL541_01320 ENOG4105ETT transcriptional Regulator, LysR family AL541_01330 ENOG4108RCM Nitroreductase AL541_01335 ENOG4108ZX5 transcriptional regulator AL541_01345 ENOG4105DZ1 carboxypeptidase AL541_01355 ENOG4105C72 UPF0176 protein AL541_01365 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL541_01375 ENOG4108M1A Chitin-binding protein AL541_01380 ENOG4108NRW Phospholipase, patatin family AL541_01385 ENOG41081FY multiple antibiotic resistance (MarC)-related AL541_01395 ENOG4105DAY polysaccharide export protein AL541_01405 ENOG4105D75 Capsular exopolysaccharide family AL541_01415 ENOG4105N0V mono-oxygenase ydhR AL541_01420 ENOG4105F04 LysR family Transcriptional regulator AL541_01430 ENOG4105CK2 sodium dicarboxylate symporter AL541_01450 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL541_01455 ENOG4108P2H Inner membrane protein YjiG AL541_01460 ENOG41074DU domain protein AL541_01475 ENOG4107T9C Alpha amylase catalytic region AL541_01480 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AL541_01485 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AL541_01490 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AL541_01495 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AL541_01500 ENOG41061ZR Transcriptional regulator AL541_01525 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL541_01530 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AL541_01535 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AL541_01555 ENOG4108K8S endonuclease I AL541_01575 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AL541_01585 ENOG4105EJQ L-serine dehydratase AL541_01595 ENOG4105D2S major facilitator superfamily AL541_01620 ENOG4105CHR reductase AL541_01625 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AL541_01630 ENOG4105CNV Aldolase AL541_01635 ENOG4105ETE Transcriptional regulator (LacI family AL541_01640 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL541_01650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL541_01665 ENOG4107RJ1 sodium solute AL541_01670 ENOG4105ETE Transcriptional regulator (LacI family AL541_01680 ENOG4105E5M Multidrug resistance protein D AL541_01695 ENOG4105DR5 peptidase AL541_01705 ENOG4107RAN Peptidase, M16 AL541_01710 ENOG4105C8Q Methyl-accepting chemotaxis AL541_01715 ENOG4105E0A ABC, transporter AL541_01720 ENOG4108U1V ABC transporter, permease AL541_01725 ENOG4105DQ5 transport system permease protein AL541_01730 ENOG4108HUF Transporter AL541_01735 ENOG4105GAV receptor AL541_01740 ENOG4105E0K tonB-dependent siderophore receptor AL541_01750 ENOG4105DUU IucA IucC family protein AL541_01760 ENOG4105DBM Siderophore biosynthesis protein AL541_01765 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL541_01770 ENOG4108JP0 extracellular solute-binding protein family 1 AL541_01775 ENOG4105DHQ Histidine kinase AL541_01780 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL541_01790 ENOG4105CI1 PTS System AL541_01810 ENOG4105C19 ABC transporter AL541_01860 ENOG4108ZHJ Organic hydroperoxide resistance protein AL541_01865 ENOG4105K56 Transcriptional regulator AL541_01870 ENOG4105D3R alkyl hydroperoxide reductase AL541_01875 ENOG4108JU3 Alkyl hydroperoxide reductase AL541_01890 ENOG4107RRE RNA-directed DNA polymerase AL541_01915 ENOG4105ECQ AraC Family Transcriptional Regulator AL541_01940 ENOG4108RPX mosc domain containing protein AL541_01945 ENOG4105C1J atp-dependent rna helicase AL541_01955 ENOG4105BZ1 (ABC) transporter AL541_01965 ENOG4105EW9 transcriptional regulator AsnC family AL541_01995 ENOG4105CK7 Sodium proline symporter AL541_02005 ENOG4105C26 Dehydrogenase AL541_02020 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AL541_02025 ENOG4105CQZ Histidine kinase AL541_02030 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_02035 ENOG4107QZV Type I secretion membrane fusion protein AL541_02050 ENOG4108JJA ABC, transporter AL541_02065 ENOG4108J59 Extracellular solute-binding protein, family 5 AL541_02075 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) AL541_02085 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL541_02090 ENOG4105C5Y PTS System AL541_02095 ENOG4105FCK Membrane AL541_02100 ENOG4105EC3 peptidase S51, dipeptidase E AL541_02105 ENOG4105EQ2 LysR family Transcriptional regulator AL541_02120 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AL541_02145 ENOG4108JQ7 (ABC) transporter AL541_02170 ENOG4105BZU Histidine kinase AL541_02180 ENOG4105CDY transcriptional regulatory protein AL541_02185 ENOG4105CNI cell division protein FtsW AL541_02195 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL541_02215 ENOG4108HRK Histidine kinase AL541_02220 ENOG4108VAC response regulator AL541_02225 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL541_02230 ENOG4105C8Q Methyl-accepting chemotaxis AL541_02250 ENOG4105D6U Sodium Glutamate Symporter AL541_02260 ENOG4105CZV ABC transporter AL541_02265 ENOG4107U9B transcriptional regulator AL541_02270 ENOG4105D6U Sodium Glutamate Symporter AL541_02280 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AL541_02300 ENOG4105C2I pirin domain protein AL541_02305 ENOG4108VGI doxx family AL541_02315 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AL541_02320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AL541_02340 ENOG4105DN9 Na H antiporter AL541_02355 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL541_02370 ENOG4105NBK UPF0345 protein AL541_02380 ENOG4108K0B C-di-gmp phosphodiesterase AL541_02385 ENOG4105UQX Mate efflux family protein AL541_02390 ENOG4105D3G Pseudouridine synthase AL541_02405 ENOG4105EJC lysr family transcriptional regulator AL541_02410 ENOG4108HCJ Hydrolase AL541_02420 ENOG4108KHX Diguanylate cyclase AL541_02430 ENOG4105C4W S-formylglutathione hydrolase AL541_02440 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AL541_02445 ENOG4105CC0 LysR family Transcriptional regulator AL541_02450 ENOG4105Q26 Siderophore-interacting protein AL541_02460 ENOG4105EW9 transcriptional regulator AsnC family AL541_02480 ENOG4107W31 Pentapeptide repeat protein AL541_02485 ENOG4105EIF outer membrane protein W AL541_02495 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL541_02510 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AL541_02545 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AL541_02550 ENOG4105C6Z Gluconate AL541_02555 ENOG4105BZW Glycerate kinase AL541_02560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL541_02595 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL541_02600 ENOG41068WN AL541_02605 ENOG4105CUW cytochrome C-TYPE protein AL541_02610 ENOG4107QY8 reductase AL541_02620 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AL541_02625 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AL541_02630 ENOG4105ETU transcriptional activator (TenA AL541_02635 ENOG4107Z6I Thiamine biosynthesis protein AL541_02640 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AL541_02645 ENOG4108YI8 ABC transporter AL541_02650 ENOG4105DWF phosphomethylpyrimidine kinase AL541_02665 ENOG4108TEM pseudouridine methyltransferase AL541_02720 ENOG4108YYI Protein of unknown function (DUF2810) AL541_02725 ENOG4105C5I Dehydrogenase AL541_02735 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AL541_02740 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL541_02745 ENOG410804D Sensor Signal Transduction Histidine Kinase AL541_02770 ENOG4109015 Biopolymer transport protein exbD tolR AL541_02820 ENOG4105DSE periplasmic solute binding protein AL541_02825 ENOG4105DIK (ABC) transporter AL541_02830 ENOG4105CC5 ABC transporter AL541_02845 ENOG4105CUG Oligopeptidase b AL541_02850 ENOG4105E5M Multidrug resistance protein D AL541_02860 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AL541_02870 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL541_02875 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL541_02900 ENOG4105DUM transcriptional regulator, lysR family AL541_02925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_02930 ENOG4105BZU Histidine kinase AL541_02935 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL541_02955 ENOG4105D5U fad dependent oxidoreductase AL541_02960 ENOG4105NVB glycoside hydrolase, family 19 AL541_02980 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL541_02985 ENOG4105C4M (Ubiquinol oxidase) subunit I AL541_02990 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL541_02995 ENOG4105C0F tryptophanase EC 4.1.99.1 AL541_03015 ENOG4105D9N nucleoside AL541_03030 ENOG4105BZU Histidine kinase AL541_03045 ENOG4106TD9 Diguanylate cyclase AL541_03050 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL541_03055 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AL541_03070 ENOG4105E0X reductase AL541_03075 ENOG4108UKZ OsmC family AL541_03080 ENOG4108UW5 maltose o-acetyltransferase AL541_03115 ENOG4105JQN Transcriptional regulator AL541_03120 ENOG4105PAD Hydrolase AL541_03135 ENOG4108UUE Transcriptional regulator AL541_03145 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL541_03155 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL541_03160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL541_03175 ENOG4105MKU Transcriptional regulator AL541_03180 ENOG4105KUU lipolytic protein G-D-S-L family AL541_03185 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AL541_03210 ENOG4105ETE Transcriptional regulator (LacI family AL541_03215 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AL541_03220 ENOG4108JPW Aminotransferase AL541_03225 ENOG4107STF Involved in phosphonate degradation (By similarity) AL541_03240 ENOG4107RCV ABC transporter, permease AL541_03260 ENOG4108MJ5 VirK protein AL541_03270 ENOG4105CJP fad dependent oxidoreductase AL541_03285 ENOG4105ETT transcriptional Regulator, LysR family AL541_03300 ENOG4105EJQ L-serine dehydratase AL541_03320 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL541_03325 ENOG4105E9H Lytic Murein transglycosylase AL541_03345 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL541_03350 ENOG4108ZC9 flagellar basal-body rod protein flgc AL541_03355 ENOG4105W00 Flagellar hook capping protein AL541_03360 ENOG4105BZE flagellar hook protein, FlgE AL541_03365 ENOG4108KPB Flagellar basal-body rod protein FlgF AL541_03370 ENOG4105CGA flagellar basal-body rod protein FlgG AL541_03375 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL541_03380 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL541_03385 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL541_03390 ENOG4105E1Q flagellar hook-associated protein AL541_03395 ENOG4105DTJ flagellar hook-associated protein AL541_03415 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AL541_03430 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL541_03435 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL541_03440 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL541_03450 ENOG4105N14 lysine exporter protein LysE YggA AL541_03470 ENOG4107Z3H Transcriptional regulator, TetR family AL541_03475 ENOG4108K3Z AraC family transcriptional regulator AL541_03480 ENOG4105CPD ethanolamine ammonia-lyase AL541_03485 ENOG4107FQ9 ethanolamine ammonia-lyase AL541_03490 ENOG4105CUB amino acid AL541_03495 ENOG4105EA8 2-Nitropropane dioxygenase AL541_03500 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL541_03505 ENOG4105N2W Transcriptional regulator AL541_03520 ENOG4108RWI nicotinamidase AL541_03530 ENOG4107RH7 Nicotinate phosphoribosyltransferase AL541_03555 ENOG4105ETT transcriptional Regulator, LysR family AL541_03570 ENOG4105RW8 MltA-interacting MipA family protein AL541_03575 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AL541_03580 ENOG4108IJ7 Glycine betaine AL541_03585 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component AL541_03595 ENOG4105VYW UPF0251 protein AL541_03620 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL541_03630 ENOG4107S8C mandelate racemase muconate lactonizing AL541_03640 ENOG4105RQF LysR family Transcriptional regulator AL541_03655 ENOG4108Z4X TRANSCRIPTIONal AL541_03680 ENOG4107RZC phospholipase d AL541_03710 ENOG4105BZS acriflavin resistance protein AL541_03730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL541_03780 ENOG4107RUE extracellular solute-binding protein family 1 AL541_03785 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL541_03790 ENOG4105WH1 Two component transcriptional regulator luxr family AL541_03805 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AL541_03810 ENOG4105HDK L-asparaginase AL541_03815 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL541_03835 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AL541_03840 ENOG4105C8Y Acetylornithine aminotransferase AL541_03845 ENOG4105C26 Dehydrogenase AL541_03850 ENOG4108RYR transcriptional regulator AsnC family AL541_03855 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase AL541_03860 ENOG4105ENR peptidase, M24 AL541_03865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL541_03875 ENOG4105CHR reductase AL541_03885 ENOG4105CPQ Dehydrogenase AL541_03890 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL541_03905 ENOG4107RSM transcriptional regulator AL541_03915 ENOG4105C1J atp-dependent rna helicase AL541_03945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL541_03950 ENOG410874W AraC family transcriptional regulator AL541_03955 ENOG4105HEI LysR family (Transcriptional regulator AL541_03960 ENOG4105E1F short-chain dehydrogenase reductase AL541_03975 ENOG4108P3C AL541_03990 ENOG4105CHR reductase AL541_03995 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AL541_04005 ENOG41064T2 transcriptional regulator, lysR family AL541_04010 ENOG4105D05 Receptor AL541_04030 ENOG4105C5Y PTS System AL541_04035 ENOG4105D7K pfkb domain protein AL541_04040 ENOG4108HKT sucrose-6-phosphate hydrolase AL541_04045 ENOG4105NAE bifunctional deaminase-reductase domain protein AL541_04055 ENOG4105CYM Glutathione S-transferase AL541_04065 ENOG4105DZ1 carboxypeptidase AL541_04080 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL541_04095 ENOG4105VEQ Cold shock protein AL541_04100 ENOG4105EUB pirin domain protein AL541_04105 ENOG4108NRW Phospholipase, patatin family AL541_04120 ENOG4105EP9 oxidoreductase AL541_04125 ENOG4105DIJ Phosphoethanolamine transferase AL541_04130 ENOG41080IJ Diacylglycerol kinase AL541_04140 ENOG4105E0F Histidine kinase AL541_04145 ENOG4107EXC regulatoR AL541_04160 ENOG4108Z33 Thiol disulfide Interchange Protein AL541_04180 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AL541_04190 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL541_04205 ENOG4105EST Metal Dependent Phosphohydrolase AL541_04210 ENOG4105DZC cytosine deaminase AL541_04215 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin AL541_04220 ENOG4105CJW magnesium transporter AL541_04225 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL541_04230 ENOG4105EFX secretion protein, HlyD family AL541_04255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL541_04260 ENOG4105E0F Histidine kinase AL541_04275 ENOG4105DVH amino acid AL541_04290 ENOG4105DUM transcriptional regulator, lysR family AL541_04310 ENOG4105BZU Histidine kinase AL541_04320 ENOG41090HJ UPF0265 protein AL541_04330 ENOG4108YXG UPF0502 protein AL541_04335 ENOG41082IR Excinuclease ABC C subunit domain protein AL541_04345 ENOG4108QGH periplasmic AL541_04350 ENOG4105BZU Histidine kinase AL541_04355 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AL541_04360 ENOG4105J12 Multidrug resistance protein mdtN AL541_04380 ENOG4105EW9 transcriptional regulator AsnC family AL541_04410 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL541_04415 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL541_04435 ENOG4105CHU acetyl-coa acetyltransferase AL541_04445 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AL541_04465 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL541_04480 ENOG4105BZU Histidine kinase AL541_04485 ENOG4105WH1 Two component transcriptional regulator luxr family AL541_04500 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL541_04505 ENOG4107YWA deoxycytidylate deaminase AL541_04520 ENOG4108N3W hemolysin secretion protein AL541_04525 ENOG4108YZN class I peptide chain release factor AL541_04530 ENOG4107VXZ Hydrolase AL541_04535 ENOG4105UYK outer membrane protein a AL541_04545 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL541_04550 ENOG4105DXI Major Facilitator superfamily AL541_04560 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL541_04565 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL541_04585 ENOG4105KHC sulfurtransferase AL541_04600 ENOG4105D06 uba thif-type nad fad binding protein AL541_04605 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL541_04610 ENOG4105EUJ GTP cyclohydrolase i AL541_04620 ENOG4105CMQ Chloride channel AL541_04635 ENOG4107RGM aldo keto reductase AL541_04640 ENOG4108UNF response regulator AL541_04650 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AL541_04655 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL541_04680 ENOG4105CWX Alpha-1,2-mannosidase AL541_04685 ENOG4105CWX Alpha-1,2-mannosidase AL541_04695 ENOG4105CWX Alpha-1,2-mannosidase AL541_04700 ENOG4105CWX Alpha-1,2-mannosidase AL541_04705 ENOG4105DM4 PTS System AL541_04715 ENOG4105EIP mannose-6-phosphate isomerase AL541_04720 ENOG4105DM4 PTS System AL541_04725 ENOG4106R3P AraC family transcriptional regulator AL541_04735 ENOG4108YRF PTS System AL541_04740 ENOG4105DM4 PTS System AL541_04765 ENOG4105DR5 peptidase AL541_04790 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_04795 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL541_04800 ENOG4108WC9 type VI secretion system effector, hcp1 family AL541_04805 ENOG4105CS6 Rhs element vgr protein AL541_04830 ENOG4105D9P serine threonine protein kinase AL541_04865 ENOG4105EW9 transcriptional regulator AsnC family AL541_04930 ENOG4105C2C drug resistance transporter, Bcr CflA AL541_04940 ENOG4105HEI LysR family (Transcriptional regulator AL541_04945 ENOG4105EMU Dehydrogenase AL541_04950 ENOG4105Q9Y Universal stress protein AL541_04960 ENOG4105D65 subunit l AL541_04965 ENOG4105MKQ Monovalent cation H antiporter subunit C AL541_04970 ENOG4108JPZ Monovalent cation H antiporter subunit D AL541_04975 ENOG4105SC1 monovalent cation H antiporter subunit E AL541_04980 ENOG41080TA Multiple resistance and ph regulation protein f AL541_04985 ENOG4105KJM monovalent cation h antiporter subunit g AL541_04990 ENOG4105FDP GntR family transcriptional regulator AL541_04995 ENOG4105F8D glycoside hydrolase family 4 AL541_05000 ENOG4105CI1 PTS System AL541_05005 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL541_05010 ENOG4105C10 Electron transfer flavoprotein AL541_05015 ENOG4105BZJ Electron transfer flavoprotein AL541_05020 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL541_05030 ENOG4105C0Z ABC transporter AL541_05035 ENOG4108IQE Amp-dependent synthetase and ligase AL541_05055 ENOG4108IV0 ABC, transporter AL541_05060 ENOG4105DZS Phenylacetate-CoA ligase AL541_05065 ENOG4105FQ6 thiopurine methyltransferase AL541_05095 ENOG4105C94 Transporter AL541_05100 ENOG4105CHR reductase AL541_05105 ENOG4105C7K acetolactate synthase AL541_05110 ENOG4107FQX Alpha-acetolactate decarboxylase AL541_05120 ENOG4107YBY Hydrolase AL541_05135 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL541_05140 ENOG4105C4M (Ubiquinol oxidase) subunit I AL541_05145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL541_05150 ENOG4108UW5 maltose o-acetyltransferase AL541_05160 ENOG4105EGS Mechanosensitive ion channel AL541_05170 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL541_05180 ENOG4108IPT Naphthoate synthase AL541_05185 ENOG4107QX3 carboxylase AL541_05190 ENOG4105C1G acyl-Coa dehydrogenase AL541_05200 ENOG4105CHU acetyl-coa acetyltransferase AL541_05205 ENOG4105C26 Dehydrogenase AL541_05210 ENOG4105C1G acyl-Coa dehydrogenase AL541_05215 ENOG4105E39 Enoyl-CoA hydratase AL541_05225 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL541_05235 ENOG4105BZU Histidine kinase AL541_05240 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AL541_05245 ENOG4105C26 Dehydrogenase AL541_05250 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AL541_05260 ENOG4108HQS Glycine betaine AL541_05265 ENOG4108IJ7 Glycine betaine AL541_05270 ENOG4108RCM Nitroreductase AL541_05280 ENOG4107QX8 SPFH domain, Band 7 family protein AL541_05290 ENOG4105CA0 peroxidase AL541_05295 ENOG4105BZU Histidine kinase AL541_05305 ENOG4105D82 Glutamate dehydrogenase AL541_05360 ENOG4108K0B C-di-gmp phosphodiesterase AL541_05365 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AL541_05370 ENOG4105C2J ABC transporter AL541_05375 ENOG4105CNN ABC, transporter AL541_05380 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AL541_05385 ENOG4108RVA ribokinase AL541_05390 ENOG4105ETE Transcriptional regulator (LacI family AL541_05400 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AL541_05405 ENOG4108I5U Uridine phosphorylase AL541_05420 ENOG4105DHS permease protein AL541_05425 ENOG4105CM4 permease protein AL541_05430 ENOG4108IPW abc transporter atp-binding protein AL541_05435 ENOG4108Z6Z Transcriptional regulator AL541_05480 ENOG4105EM2 membrane AL541_05485 ENOG41088T4 Helicase IV AL541_05490 ENOG4108Z5K methylglyoxal synthase AL541_05495 ENOG4108SV3 Tmao reductase system periplasmic protein tort AL541_05500 ENOG4105BZU Histidine kinase AL541_05515 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL541_05520 ENOG4105ENH Sulfatase AL541_05530 ENOG41061MV Arylsulfatase AL541_05535 ENOG4105C4X radical SAM domain protein AL541_05540 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL541_05570 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL541_05575 ENOG41064T2 transcriptional regulator, lysR family AL541_05580 ENOG4107TE5 Lipid kinase AL541_05585 ENOG4108YDI single-species biofilm formation on inanimate substrate AL541_05595 ENOG4105F2V VRR-NUC domain-containing protein AL541_05610 ENOG4105CEE C4-dicarboxylate transporter AL541_05630 ENOG4108MGY Histidine kinase AL541_05635 ENOG4107KBT 8-Amino-7-oxononanoate synthase AL541_05640 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AL541_05645 ENOG4105BZU Histidine kinase AL541_05650 ENOG4105BZU Histidine kinase AL541_05655 ENOG4105WH1 Two component transcriptional regulator luxr family AL541_05660 ENOG4105BZU Histidine kinase AL541_05670 ENOG4108WQH regulatoR AL541_05680 ENOG4107R88 Chemotaxis protein (CheV) AL541_05685 ENOG4108VAU general secretion pathway protein G AL541_05695 ENOG4105FR1 rard protein AL541_05720 ENOG4108I0N Transporter, RarD family, DMT superfamily protein AL541_05735 ENOG4107RGH Aldehyde dehydrogenase AL541_05745 ENOG4105CBC glutamate synthase AL541_05750 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AL541_05765 ENOG4105EXC Acyl-transferase AL541_05775 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL541_05780 ENOG4108UYE Lactoylglutathione lyase AL541_05800 ENOG4105CJW magnesium transporter AL541_05835 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL541_05850 ENOG4105HDD phospholipase AL541_05880 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AL541_05935 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AL541_05940 ENOG4108IPJ Membrane AL541_05945 ENOG4105EJC lysr family transcriptional regulator AL541_05950 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AL541_05960 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AL541_05965 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AL541_05970 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AL541_05975 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL541_05985 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AL541_06015 ENOG4105DM4 PTS System AL541_06020 ENOG4105DE4 1-phosphofructokinase AL541_06025 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AL541_06030 ENOG4107B7Y DNA-binding transcriptional regulator FruR AL541_06045 ENOG4108NJZ Sensory box GGDEF EAL domain protein AL541_06050 ENOG4105DRP amino acid AbC transporter AL541_06055 ENOG4106TNF Periplasmic binding protein AL541_06060 ENOG4105E5Q amino acid AbC transporter AL541_06065 ENOG4105CDA abc transporter atp-binding protein AL541_06075 ENOG4108I6A alcohol dehydrogenase AL541_06080 ENOG4105CF7 AraC family transcriptional regulator AL541_06095 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL541_06100 ENOG4105CKU formyltetrahydrofolate synthetase AL541_06105 ENOG4107RE1 Inosine-guanosine kinase AL541_06120 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL541_06130 ENOG4108NVR Methyl-accepting chemotaxis AL541_06140 ENOG4108ZYK Acyl carrier protein phosphodiesterase AL541_06145 ENOG4105C1J atp-dependent rna helicase AL541_06165 ENOG4105DS1 cytochrome b561 AL541_06170 ENOG4108YYC ycei family AL541_06175 ENOG4105TMB Formate nitrite transporter AL541_06180 ENOG4105DUM transcriptional regulator, lysR family AL541_06185 ENOG4108UQ5 membrane protein YcdZ AL541_06190 ENOG4105CPB ATP-dependent endonuclease of the OLD family AL541_06195 ENOG4105CGH 5'-nucleotidase AL541_06200 ENOG4105DU1 integral membrane protein, terc AL541_06220 ENOG4108M0H Extracellular lipase AL541_06225 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL541_06240 ENOG4105KA0 thioesterase Superfamily protein AL541_06250 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AL541_06285 ENOG4105BZU Histidine kinase AL541_06290 ENOG4105RKW reductase (By AL541_06300 ENOG4108I0Y (ABC) transporter AL541_06305 ENOG4105CV6 ABC transporter, permease AL541_06315 ENOG4107R7A Allophanate hydrolase subunit 2 AL541_06320 ENOG4105P4J Allophanate hydrolase, subunit 1 AL541_06325 ENOG4105E7W lamb ycsf family protein AL541_06330 ENOG4105BZU Histidine kinase AL541_06335 ENOG4105CMR udp-glucose 4-epimerase AL541_06350 ENOG4105CWB LysR family transcriptional Regulator AL541_06355 ENOG4105CD5 CoA-binding domain protein AL541_06365 ENOG4105CPF Cell wall formation (By similarity) AL541_06375 ENOG4108ZJT translation initiation factor, Sui1 AL541_06480 ENOG4105VZ1 Replication Protein AL541_06560 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL541_06565 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL541_06580 ENOG4105BZU Histidine kinase AL541_06595 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AL541_06600 ENOG4105E0C molybdate abc transporter AL541_06605 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AL541_06610 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AL541_06615 ENOG4105WXI Bacterial OB fold (BOF) protein AL541_06625 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL541_06630 ENOG4105CGF Aromatic amino acid aminotransferase AL541_06635 ENOG4108K01 transcriptional regulator AL541_06640 ENOG4105UQX Mate efflux family protein AL541_06645 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AL541_06650 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AL541_06690 ENOG4107TIF Phenazine biosynthesis protein, PhzF family AL541_06705 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AL541_06715 ENOG4105C5Q Transcriptional regulator AL541_06720 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL541_06725 ENOG4105CXY transporter AL541_06730 ENOG4108KX4 response regulator AL541_06735 ENOG4105BZU Histidine kinase AL541_06740 ENOG4105CXY transporter AL541_06745 ENOG4105EIP mannose-6-phosphate isomerase AL541_06765 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL541_06770 ENOG4105K63 Thioredoxin AL541_06775 ENOG4108ISG Major Facilitator AL541_06780 ENOG4105VXR cytoplasmic protein AL541_06785 ENOG4105KNA -acetyltransferase AL541_06810 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL541_06825 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL541_06830 ENOG4105TMB Formate nitrite transporter AL541_06835 ENOG4105WZK nitrite reductase NADPH small subunit AL541_06840 ENOG4107QZF nitrite reductase NADPH large subunit AL541_06845 ENOG4105NXH GreA GreB family elongation factor AL541_06855 ENOG4105BZU Histidine kinase AL541_06865 ENOG4105BZU Histidine kinase AL541_06870 ENOG4105DEN Luciferase family AL541_06920 ENOG4108NVR Methyl-accepting chemotaxis AL541_06925 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL541_06940 ENOG4105CXG d-lactate dehydrogenase AL541_06945 ENOG4105CC0 LysR family Transcriptional regulator AL541_06960 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AL541_06965 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) AL541_06975 ENOG4105C5W Aldolase AL541_06985 ENOG4105CSX c4-dicarboxylate anaerobic carrier AL541_06995 ENOG4105QNF Outer membrane lipoprotein AL541_07005 ENOG4105EYH Exonuclease AL541_07010 ENOG4107RFY SbcCD D subunit AL541_07035 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL541_07080 ENOG4108ZF3 Phosphatase AL541_07095 ENOG4106VK6 Flagellar motor protein AL541_07115 ENOG4105D9P serine threonine protein kinase AL541_07135 ENOG4105F8J Adenylate Guanylate cyclase AL541_07165 ENOG4107QZF nitrite reductase NADPH large subunit AL541_07170 ENOG4105D7T ABC transporter AL541_07175 ENOG4105DG7 nitrate ABC transporter AL541_07220 ENOG4105C44 Serine transporter AL541_07230 ENOG4105BZU Histidine kinase AL541_07260 ENOG4105ETX regulatoR AL541_07295 ENOG4106E5D Protein of unknown function (DUF461) AL541_07300 ENOG4105CHR reductase AL541_07305 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AL541_07315 ENOG4108UHU Aldolase AL541_07320 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AL541_07325 ENOG4105M5J Cupin 2, conserved barrel domain protein AL541_07330 ENOG4105EY3 heparinase II III family protein AL541_07335 ENOG4105EY3 heparinase II III family protein AL541_07370 ENOG4107EJG GntR family transcriptional regulator AL541_07375 ENOG4107EJG GntR family transcriptional regulator AL541_07380 ENOG41080XP Cbs domain AL541_07385 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AL541_07390 ENOG4107RJ1 sodium solute AL541_07405 ENOG4107RUY (E1 component), alpha subunit AL541_07415 ENOG4107QSN dihydrolipoamide acetyltransferase AL541_07420 ENOG4105C10 Electron transfer flavoprotein AL541_07425 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL541_07430 ENOG4105EXG Transcriptional regulator AL541_07445 ENOG4105DUM transcriptional regulator, lysR family AL541_07455 ENOG4105DMR ABC, transporter AL541_07460 ENOG4105GBT ABC transporter AL541_07465 ENOG4106PMH Extracellular solute-binding protein family 3 AL541_07470 ENOG4105E5Z arginine transporter ATP-binding subunit AL541_07510 ENOG4105C26 Dehydrogenase AL541_07525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL541_07530 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL541_07540 ENOG4105CCU oxidase (Subunit III) AL541_07545 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL541_07550 ENOG4105E2S oxidase) subunit II AL541_07555 ENOG4105CHR reductase AL541_07560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL541_07565 ENOG4105E39 Enoyl-CoA hydratase AL541_07570 ENOG4105E39 Enoyl-CoA hydratase AL541_07580 ENOG4105C26 Dehydrogenase AL541_07585 ENOG4105CHU acetyl-coa acetyltransferase AL541_07595 ENOG4105C1G acyl-Coa dehydrogenase AL541_07600 ENOG4107QX3 carboxylase AL541_07605 ENOG4105E39 Enoyl-CoA hydratase AL541_07610 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL541_07620 ENOG4107SDU Methyl-accepting chemotaxis AL541_07630 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AL541_07640 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AL541_07650 ENOG4105CKI cobalamin synthesis protein AL541_07660 ENOG4105DR5 peptidase AL541_07670 ENOG4105CKI cobalamin synthesis protein AL541_07685 ENOG4105MYN Zinc uptake regulation protein AL541_07700 ENOG4105HF0 Membrane AL541_07715 ENOG4105ENX hydrolase AL541_07720 ENOG4105ENX hydrolase AL541_07725 ENOG4105EQ2 LysR family Transcriptional regulator AL541_07730 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL541_07745 ENOG4105C1J atp-dependent rna helicase AL541_07750 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) AL541_07765 ENOG4105CVA phosphate AL541_07785 ENOG4105DKW ABC transporter AL541_07790 ENOG4105CXC rtn protein AL541_07810 ENOG4105C1J atp-dependent rna helicase AL541_07815 ENOG4105CKI cobalamin synthesis protein AL541_07825 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AL541_07835 ENOG4105VEQ Cold shock protein AL541_07845 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL541_07855 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL541_07860 ENOG4105C1J atp-dependent rna helicase AL541_07865 ENOG4105CNH Multidrug resistance protein MdtL AL541_07870 ENOG4105G2Y Transcriptional regulator AL541_07880 ENOG4105VRT cytoplasmic protein AL541_07900 ENOG41090A4 Pterin carbinolamine dehydratase AL541_07905 ENOG4105MIR Phenylalanine 4-monooxygenase AL541_07910 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL541_07915 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL541_07935 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AL541_07940 ENOG4105C0A alcohol dehydrogenase AL541_07950 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AL541_07960 ENOG4108RMU ferritin dps family protein AL541_07965 ENOG4105C8Q Methyl-accepting chemotaxis AL541_07990 ENOG4108MGY Histidine kinase AL541_07995 ENOG4105DFG type I secretion outer membrane protein AL541_08005 ENOG4105BZ1 (ABC) transporter AL541_08015 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL541_08020 ENOG4105BZU Histidine kinase AL541_08025 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system AL541_08030 ENOG4105VEQ Cold shock protein AL541_08050 ENOG4105CDV Ompa motb domain protein AL541_08060 ENOG4108V1T peptidylprolyl cis-trans isomerase AL541_08065 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL541_08070 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AL541_08095 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) AL541_08140 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AL541_08155 ENOG4108SXK Transporter Drug Metabolite Exporter family AL541_08160 ENOG4105VW4 glutaredoxin 3 AL541_08175 ENOG4105E5M Multidrug resistance protein D AL541_08180 ENOG4105CR8 Transcriptional regulator AL541_08190 ENOG4105DR5 peptidase AL541_08215 ENOG4105DWD nucleoside recognition domain protein AL541_08220 ENOG4105C8Q Methyl-accepting chemotaxis AL541_08230 ENOG4105E0U tyrosine-specific transport protein AL541_08255 ENOG4107RGM aldo keto reductase AL541_08260 ENOG4105JQN Transcriptional regulator AL541_08280 ENOG4105KVH Transcriptional regulator AL541_08295 ENOG4105D6J arsenicaL-resistance protein AL541_08305 ENOG4108V1U phospholipid-binding protein AL541_08310 ENOG4105JAB phenazine biosynthesis protein, phzf family AL541_08320 ENOG4105CJ1 ABC, transporter AL541_08325 ENOG4107QWP ABC-2 type transporter AL541_08335 ENOG4108IEG Formate dehydrogenase Alpha subunit AL541_08355 ENOG4108IJF Heavy metal efflux pump, CzcA AL541_08405 ENOG4105CBT Fructose-1,6-bisphosphatase AL541_08410 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AL541_08415 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL541_08420 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AL541_08425 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AL541_08430 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AL541_08440 ENOG4105ETE Transcriptional regulator (LacI family AL541_08445 ENOG4105C25 Primosomal protein n' AL541_08455 ENOG4105VFB Binds the 23S rRNA (By similarity) AL541_08460 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AL541_08465 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AL541_08470 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AL541_08475 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AL541_08480 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AL541_08485 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AL541_08490 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AL541_08495 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AL541_08500 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AL541_08505 ENOG41083MP 50s ribosomal protein l29 AL541_08510 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AL541_08515 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AL541_08520 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AL541_08525 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AL541_08530 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AL541_08535 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AL541_08540 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AL541_08550 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AL541_08555 ENOG4105VPB 50S ribosomal protein L30 AL541_08560 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AL541_08565 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AL541_08575 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AL541_08580 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AL541_08585 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AL541_08590 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL541_08595 ENOG4108ZT0 50S ribosomal protein l17 AL541_08605 ENOG4108V1T peptidylprolyl cis-trans isomerase AL541_08615 ENOG4107YB6 acetyltransferase, (GNAT) family AL541_08620 ENOG4105C1J atp-dependent rna helicase AL541_08630 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AL541_08635 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL541_08640 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AL541_08645 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AL541_08655 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AL541_08675 ENOG4108I0Y (ABC) transporter AL541_08690 ENOG4108UUE Transcriptional regulator AL541_08695 ENOG41061GZ Protein of unknown function (DUF1107) AL541_08700 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL541_08705 ENOG4105CFU surface antigen AL541_08710 ENOG4105MA0 exported protein AL541_08715 ENOG41066HZ AIG2-like family AL541_08725 ENOG4105F0N pyrophosphate phospho-hydrolase AL541_08730 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AL541_08740 ENOG4105DFU Cell wall formation (By similarity) AL541_08745 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AL541_08750 ENOG4105DP9 ABC transporter AL541_08755 ENOG4106SMU thiamine transporter membrane protein AL541_08760 ENOG4107T0D ABC, transporter AL541_08765 ENOG4105CC0 LysR family Transcriptional regulator AL541_08770 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL541_08800 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AL541_08805 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AL541_08815 ENOG4105EAH synthase AL541_08820 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AL541_08825 ENOG4105K46 50S ribosomal protein l27 AL541_08830 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AL541_08835 ENOG4105DWK Membrane AL541_08840 ENOG4107XM3 UPF0442 protein AL541_08845 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AL541_08850 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AL541_08855 ENOG4105NWN ApaG protein AL541_08860 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AL541_08865 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AL541_08870 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AL541_08875 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AL541_08880 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AL541_08890 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL541_08895 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL541_08900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AL541_08905 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AL541_08930 ENOG41064T2 transcriptional regulator, lysR family AL541_08935 ENOG4108IQE Amp-dependent synthetase and ligase AL541_08940 ENOG4105C7K acetolactate synthase AL541_08945 ENOG4108ZP8 Acetolactate synthase small subunit AL541_08950 ENOG4105BZU Histidine kinase AL541_08960 ENOG4105CA9 Pyruvate kinase AL541_08965 ENOG410804X Transcriptional regulator AL541_08970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AL541_08980 ENOG4105CMT Dihydroxyacetone kinase AL541_08985 ENOG4108UTZ Dihydroxyacetone kinase AL541_09000 ENOG4105E61 Mannitol repressor protein AL541_09005 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AL541_09010 ENOG4105CTS PTS system mannitol-specific AL541_09030 ENOG4105D01 (LipO)protein AL541_09085 ENOG4105CAF HipA N-terminal domain protein AL541_09110 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL541_09120 ENOG4105CAF HipA N-terminal domain protein AL541_09135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL541_09140 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AL541_09145 ENOG4105KTH gatB Yqey AL541_09150 ENOG4105VCC 30S ribosomal protein S21 AL541_09155 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL541_09160 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AL541_09165 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AL541_09170 ENOG4107ZVW dihydroneopterin aldolase AL541_09175 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL541_09180 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AL541_09185 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AL541_09200 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL541_09205 ENOG4106MWK domain protein AL541_09210 ENOG4105CJ3 phosphate transporter AL541_09215 ENOG4107IX6 phosphate transport regulator AL541_09220 ENOG4105I7R Adenylate cyclase AL541_09230 ENOG4105C8Q Methyl-accepting chemotaxis AL541_09235 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AL541_09240 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AL541_09245 ENOG4105DFG type I secretion outer membrane protein AL541_09250 ENOG41087AY ADP-Ribose pyrophosphatase AL541_09255 ENOG4108SX3 cytoplasmic protein AL541_09260 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AL541_09265 ENOG4105IPS esterase AL541_09270 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL541_09275 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL541_09280 ENOG4105C0H protease AL541_09285 ENOG4105C0H protease AL541_09290 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AL541_09300 ENOG4105D6Z AFG1 family ATPase AL541_09310 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AL541_09315 ENOG4108UJD 30S ribosomal protein S9 AL541_09320 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL541_09325 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL541_09330 ENOG4105EIX cytochrome c1 AL541_09335 ENOG4107MKT Stringent starvation protein a AL541_09340 ENOG4105KB2 stringent starvation protein b AL541_09345 ENOG4105W4M Transport-associated protein AL541_09350 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL541_09355 ENOG41082RQ UPF0102 protein AL541_09365 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AL541_09380 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AL541_09385 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL541_09390 ENOG4105CJN penicillin-binding protein AL541_09395 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AL541_09400 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AL541_09405 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AL541_09410 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AL541_09420 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AL541_09425 ENOG4105DFU Cell wall formation (By similarity) AL541_09430 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AL541_09435 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AL541_09440 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AL541_09445 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL541_09455 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL541_09460 ENOG4105M6F mutator MutT protein AL541_09465 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AL541_09470 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AL541_09475 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AL541_09490 ENOG4105EJ9 Membrane AL541_09495 ENOG4105VP0 transcriptional regulator, lysR family AL541_09500 ENOG4105EN6 Membrane AL541_09505 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AL541_09510 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AL541_09515 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AL541_09525 ENOG4105BZ8 glutamate synthase AL541_09530 ENOG4105CBC glutamate synthase AL541_09545 ENOG4105N5T Radical SAM Protein AL541_09555 ENOG4105BZU Histidine kinase AL541_09565 ENOG41065U4 response regulator AL541_09580 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL541_09600 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AL541_09605 ENOG4105D98 threonine synthase AL541_09615 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) AL541_09620 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AL541_09630 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AL541_09645 ENOG4105BZG amino acid carrier protein AL541_09650 ENOG4105D1Q UPF0246 protein AL541_09655 ENOG4105C1J atp-dependent rna helicase AL541_09660 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AL541_09665 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL541_09670 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AL541_09675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL541_09680 ENOG4105T95 Thiol disulfide interChange protein AL541_09685 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AL541_09695 ENOG4105CRK lysyL-tRNA synthetase AL541_09700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_09710 ENOG4105CPC Aldo Keto reductase AL541_09720 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) AL541_09725 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AL541_09730 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AL541_09735 ENOG4105HF0 Membrane AL541_09740 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AL541_09745 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AL541_09760 ENOG41063Z6 transcriptional regulator, lysR family AL541_09765 ENOG41080HT Transcriptional regulator, arsr family AL541_09770 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AL541_09775 ENOG4105CJR Integral membrane protein (MviN AL541_09780 ENOG4105DTN riboflavin biosynthesis protein ribF AL541_09785 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL541_09790 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AL541_09795 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AL541_09800 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AL541_09810 ENOG4108NEV two component transcriptional regulator, LytTR family AL541_09815 ENOG4108HRK Histidine kinase AL541_09835 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL541_09840 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AL541_09845 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AL541_09850 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL541_09855 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AL541_09860 ENOG4105DR5 peptidase AL541_09870 ENOG4105C5H ABC transporter AL541_09875 ENOG4107SC1 transglycosylase AL541_09880 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) AL541_09885 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL541_09895 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AL541_09905 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL541_09910 ENOG4105C34 Pseudouridine synthase AL541_09915 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AL541_09920 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL541_09985 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AL541_09990 ENOG4105CFP Peptidase U32 AL541_09995 ENOG4105DH7 May be involved in recombination (By similarity) AL541_10005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL541_10010 ENOG4105BZU Histidine kinase AL541_10020 ENOG4105C9X ppx gppa phosphatase AL541_10025 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AL541_10030 ENOG4105C8U phosphate abc transporter AL541_10035 ENOG4105E2Z phosphate ABC transporter (Permease AL541_10040 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL541_10050 ENOG4105CSR polyphosphate kinase 2 AL541_10055 ENOG4106N3A copper homeostasis protein cutc AL541_10060 ENOG4105D3R alkyl hydroperoxide reductase AL541_10065 ENOG4105C5Q Transcriptional regulator AL541_10070 ENOG4107QP3 malate synthase g AL541_10075 ENOG4108I9X Isocitrate lyase AL541_10080 ENOG4105W87 Cbs domain AL541_10090 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AL541_10095 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AL541_10100 ENOG4105VIE preprotein translocase, subunit YajC AL541_10105 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL541_10110 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL541_10125 ENOG4105ECY inositol monophosphatase AL541_10130 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AL541_10135 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AL541_10140 ENOG4105C3J Cysteine desulfurase AL541_10145 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AL541_10150 ENOG4108Z4V iron-sulfur cluster assembly AL541_10155 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AL541_10160 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AL541_10165 ENOG4108ZIT Ferredoxin, 2FE-2S AL541_10170 ENOG4105WVQ Fe-S assembly protein IscX AL541_10175 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AL541_10180 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AL541_10185 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AL541_10195 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AL541_10200 ENOG4105CUT histidyl-tRNA synthetase AL541_10205 ENOG4105N21 Membrane AL541_10210 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL541_10215 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AL541_10230 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL541_10235 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL541_10240 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL541_10245 ENOG4107S6Z Na H antiporter AL541_10255 ENOG4106HK8 GPR1 FUN34 yaaH family protein AL541_10260 ENOG4105BZG amino acid carrier protein AL541_10265 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL541_10275 ENOG4108IQK o-acetylhomoserine AL541_10280 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL541_10300 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AL541_10305 ENOG4105ETT transcriptional Regulator, LysR family AL541_10330 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AL541_10335 ENOG4108Z1B Cyclase dehydrase AL541_10340 ENOG4105VDB UPF0125 protein AL541_10345 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL541_10355 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AL541_10365 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AL541_10370 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AL541_10375 ENOG4105CK2 sodium dicarboxylate symporter AL541_10380 ENOG4105CFG Acts as a chaperone (By similarity) AL541_10385 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AL541_10415 ENOG4105CFC Transporter AL541_10420 ENOG4108Z6B deaminase AL541_10430 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AL541_10435 ENOG4108ETH Formylglycinamide ribotide synthetase AL541_10465 ENOG4105CIN aminoacyl-histidine dipeptidase AL541_10470 ENOG4105C7N Xanthine uracil vitamin C permease AL541_10475 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AL541_10480 ENOG4108DJV Fermentation respiration switch protein AL541_10485 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AL541_10490 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AL541_10495 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AL541_10500 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AL541_10505 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL541_10520 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AL541_10525 ENOG4107YIM Involved in the transcription termination process (By similarity) AL541_10530 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AL541_10535 ENOG4108ZAI phosphatidylglycerophosphatase a AL541_10540 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AL541_10545 ENOG4105CTB Polyprenyl synthetase AL541_10550 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL541_10555 ENOG4105E14 MotA TolQ exbB proton channel AL541_10560 ENOG4106VK6 Flagellar motor protein AL541_10565 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AL541_10570 ENOG4105ETT transcriptional Regulator, LysR family AL541_10580 ENOG4105M08 Membrane AL541_10585 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AL541_10590 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease AL541_10595 ENOG4105EWT decarboxylase family AL541_10600 ENOG4105BZU Histidine kinase AL541_10610 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AL541_10615 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AL541_10620 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein AL541_10625 ENOG4105D01 (LipO)protein AL541_10630 ENOG4108UMI ABC transporter, permease AL541_10635 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AL541_10640 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AL541_10645 ENOG4105D4X repressor AL541_10650 ENOG4105C5Y PTS System AL541_10655 ENOG4105CG3 alpha amylase, catalytic region AL541_10670 ENOG4108JYZ YitT family AL541_10675 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL541_10680 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AL541_10685 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AL541_10690 ENOG4108Z43 UPF0250 protein AL541_10695 ENOG4105DZ1 carboxypeptidase AL541_10700 ENOG4105K6T rare lipoprotein A AL541_10705 ENOG4105CNI cell division protein FtsW AL541_10710 ENOG4105CJN penicillin-binding protein AL541_10715 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AL541_10720 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AL541_10725 ENOG4105DJF DNA polymerase III, delta' subunit AL541_10730 ENOG4108U2H Rare lipoprotein B AL541_10735 ENOG4105C8T Leucyl-tRNA synthetase AL541_10740 ENOG4107PAI alpha helical protein AL541_10745 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AL541_10750 ENOG4108JU5 Magnesium and cobalt efflux protein AL541_10755 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AL541_10760 ENOG4105C9A Phoh family AL541_10765 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AL541_10775 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL541_10885 ENOG4105C3G gtp-binding protein AL541_10890 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AL541_10895 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AL541_10900 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AL541_10905 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AL541_10910 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AL541_10915 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AL541_10920 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AL541_10925 ENOG4108YY7 Invasion gene expression up-regulator SirB AL541_10930 ENOG41063JG Transcriptional regulator AL541_10935 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AL541_10940 ENOG4105CGH 5'-nucleotidase AL541_10945 ENOG4108Z66 YbaK ebsC protein AL541_10950 ENOG4105FE9 pseudouridine synthase AL541_10955 ENOG4108DG9 Smr protein MutS2 AL541_10980 ENOG4105E2D ec 3.2.1.52 AL541_10995 ENOG4105C59 p-type ATPase AL541_11005 ENOG41081QG Porin Gram-negative type AL541_11015 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AL541_11020 ENOG4105UYK outer membrane protein a AL541_11065 ENOG4107R88 Chemotaxis protein (CheV) AL541_11070 ENOG4105BZU Histidine kinase AL541_11075 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL541_11080 ENOG4108ZC9 flagellar basal-body rod protein flgc AL541_11085 ENOG4105W00 Flagellar hook capping protein AL541_11090 ENOG4105BZE flagellar hook protein, FlgE AL541_11095 ENOG4108KPB Flagellar basal-body rod protein FlgF AL541_11100 ENOG4105CGA flagellar basal-body rod protein FlgG AL541_11105 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL541_11110 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL541_11115 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL541_11125 ENOG4105DTJ flagellar hook-associated protein AL541_11130 ENOG4105I03 Flagellin AL541_11140 ENOG4105I03 Flagellin AL541_11155 ENOG4105C5Y PTS System AL541_11160 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AL541_11165 ENOG4105KZ7 phosphocarrier protein hpr AL541_11175 ENOG4105C6T cysteine synthase AL541_11180 ENOG4105EXN Sulfate transport protein CysZ AL541_11185 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AL541_11190 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AL541_11215 ENOG4107QX8 SPFH domain, Band 7 family protein AL541_11220 ENOG4107QR8 Thioredoxin AL541_11230 ENOG4105E1F short-chain dehydrogenase reductase AL541_11235 ENOG4105ECP epimerase AL541_11265 ENOG4108RE9 Phosphodiesterase AL541_11285 ENOG4108DQ1 activator toxR AL541_11290 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AL541_11295 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AL541_11300 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AL541_11305 ENOG4105DUX Transporter AL541_11310 ENOG4105MDZ Transcriptional activator rfaH AL541_11315 ENOG4105CAQ asparagine synthetase AL541_11320 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL541_11325 ENOG4105E2R ROK family AL541_11330 ENOG4105CE4 GlcNAc 6-P deacetylase AL541_11340 ENOG4105CI1 PTS System AL541_11345 ENOG4105CX6 glutaminyL-tRNA synthetase AL541_11350 ENOG41090R7 Ferric uptake AL541_11360 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AL541_11370 ENOG4105EV9 Alpha Beta Hydrolase AL541_11375 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AL541_11380 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AL541_11390 ENOG4107QNR UPF0135 protein AL541_11395 ENOG4105BZN citrate synthase AL541_11400 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AL541_11405 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AL541_11410 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AL541_11415 ENOG4105E33 succinate dehydrogenase AL541_11420 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AL541_11425 ENOG4105C7S Dehydrogenase AL541_11430 ENOG4105CMV Succinyl-CoA synthetase subunit beta AL541_11435 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AL541_11440 ENOG4105FAV ABC, transporter AL541_11445 ENOG4105FDK ABC transporter AL541_11450 ENOG4105NXV High-affinity zinc uptake system protein AL541_11455 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AL541_11460 ENOG4105XFK Ferrous iron transport protein A AL541_11485 ENOG4105C75 arginyL-tRNA synthetase AL541_11495 ENOG4106ZCM YecM protein AL541_11500 ENOG4105CIY formyltetrahydrofolate deformylase AL541_11505 ENOG4105DVT helicase AL541_11510 ENOG41072GX Peptidase M22 Glycoprotease AL541_11520 ENOG4105R8X Outer membrane lipoprotein Slp AL541_11525 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL541_11530 ENOG4105CEY Amp-dependent synthetase and ligase AL541_11535 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AL541_11540 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AL541_11545 ENOG4107QMS site-determining protein AL541_11550 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AL541_11555 ENOG4105VNG YcgL domain-containing protein AL541_11560 ENOG4105CVE Lytic murein transglycosylase AL541_11570 ENOG4105D9N nucleoside AL541_11575 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AL541_11585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL541_11590 ENOG4105C2D reductase AL541_11595 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL541_11600 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL541_11625 ENOG4105C84 Histidine ammonia-lyase AL541_11630 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AL541_11635 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL541_11655 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL541_11690 ENOG4105C1J atp-dependent rna helicase AL541_11695 ENOG4107ZYR domain protein AL541_11715 ENOG4105CNG UPF0061 protein AL541_11720 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL541_11725 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ AL541_11730 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL541_11740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_11745 ENOG4105CQZ Histidine kinase AL541_11755 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AL541_11760 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AL541_11765 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AL541_11770 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AL541_11775 ENOG4105K70 DNA-binding protein AL541_11780 ENOG4105EIN peptidylprolyl cis-trans isomerase AL541_11785 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AL541_11800 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AL541_11805 ENOG4105DK2 UPF0207 protein AL541_11810 ENOG4105CHM Aminotransferase AL541_11815 ENOG4105E4F Isochorismate synthase AL541_11820 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AL541_11830 ENOG4108IPT Naphthoate synthase AL541_11835 ENOG4105DNI Converts SHCHC to OSB (By similarity) AL541_11840 ENOG4105CEY Amp-dependent synthetase and ligase AL541_11850 ENOG4105HMI Membrane AL541_11855 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL541_11900 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AL541_11905 ENOG4105BZS acriflavin resistance protein AL541_11920 ENOG4105C6T cysteine synthase AL541_11925 ENOG4108XM1 transcriptional regulator AsnC family AL541_11935 ENOG4105C29 acyl-CoA thioesterase AL541_11940 ENOG4108MNP Glycoprotein polysaccharide metabolism AL541_11955 ENOG4105BZU Histidine kinase AL541_11970 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL541_11980 ENOG4107SXA Phosphorylase AL541_11990 ENOG4108NVR Methyl-accepting chemotaxis AL541_11995 ENOG4105K59 histidine triad (HIT) protein AL541_12020 ENOG4105D0Y UPF0227 protein AL541_12025 ENOG4105CEP NADH dehydrogenase AL541_12040 ENOG4108JA2 transcriptioN-repair coupling factor AL541_12050 ENOG4105D60 lipoprotein releasing system transmembrane protein AL541_12055 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AL541_12060 ENOG4105D60 lipoprotein releasing system transmembrane protein AL541_12070 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AL541_12080 ENOG4105BZ1 (ABC) transporter AL541_12085 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AL541_12090 ENOG4105W49 UPF0434 protein AL541_12095 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AL541_12100 ENOG4105ED1 spovr family AL541_12105 ENOG4106AKX UPF0229 protein AL541_12110 ENOG4105CYN Serine protein kinase AL541_12120 ENOG4105XWI UPF0304 protein AL541_12130 ENOG4105F1A Pyruvate formate-lyase AL541_12140 ENOG4105C6N Formate acetyltransferase AL541_12160 ENOG4108JEH abc transporter atp-binding protein AL541_12165 ENOG4105E89 ABC transporter AL541_12170 ENOG4105DSP amino acid AbC transporter AL541_12185 ENOG4105CGK Exodeoxyribonuclease III AL541_12190 ENOG4106428 Protein of unknown function (DUF2496) AL541_12195 ENOG4108URS primosomal replication protein n'' AL541_12200 ENOG4105EJ9 Membrane AL541_12205 ENOG4105DVT helicase AL541_12210 ENOG4105SDR Outer membrane protein OmpT AL541_12220 ENOG4108R99 pseudouridine synthase AL541_12230 ENOG4105VEQ Cold shock protein AL541_12235 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AL541_12240 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL541_12245 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AL541_12250 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AL541_12255 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AL541_12265 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AL541_12270 ENOG4105RKX Protein of unknown function (DUF2498) AL541_12275 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL541_12280 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL541_12285 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AL541_12305 ENOG4105HP8 regulator of competence-specific genes AL541_12310 ENOG4105ETE Transcriptional regulator (LacI family AL541_12315 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL541_12320 ENOG4106WF9 DNA-binding transcriptional regulator TorR AL541_12325 ENOG4107S90 membrAne AL541_12330 ENOG4106371 Methyltransferase AL541_12335 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) AL541_12340 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AL541_12345 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AL541_12365 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL541_12375 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AL541_12380 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AL541_12385 ENOG41081XQ Conserved Protein AL541_12390 ENOG4105C9M aspartyl-trna synthetase AL541_12395 ENOG4105CDY transcriptional regulatory protein AL541_12400 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AL541_12405 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AL541_12410 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AL541_12415 ENOG4105C4M (Ubiquinol oxidase) subunit I AL541_12420 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL541_12435 ENOG4107YD3 Thioesterase AL541_12440 ENOG4105E02 MotA TolQ exbB proton channel AL541_12445 ENOG4105M8F Biopolymer transport protein exbD tolR AL541_12455 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AL541_12460 ENOG4105KCK Peptidoglycan-associated lipoprotein AL541_12465 ENOG4105UFD tol-pal system protein YbgF AL541_12470 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AL541_12480 ENOG4105Z6B inner membrane protein yjfl AL541_12490 ENOG4106032 Glutathionylspermidine synthase AL541_12500 ENOG4105BZU Histidine kinase AL541_12505 ENOG4108RNS Exports L-alanine (By similarity) AL541_12515 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL541_12520 ENOG4105C4M (Ubiquinol oxidase) subunit I AL541_12535 ENOG4105C8Q Methyl-accepting chemotaxis AL541_12540 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL541_12545 ENOG4105BZS acriflavin resistance protein AL541_12580 ENOG4108NVR Methyl-accepting chemotaxis AL541_12585 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AL541_12595 ENOG4107R11 Transcriptional regulator AL541_12605 ENOG4105DCF alanine dehydrogenase AL541_12610 ENOG4105EW9 transcriptional regulator AsnC family AL541_12615 ENOG4105CNU cell division protein FtsK AL541_12620 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AL541_12625 ENOG4105D1H recombination factor protein RarA AL541_12630 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AL541_12645 ENOG4105KSC Transcriptional regulator, TraR DksA family AL541_12655 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AL541_12660 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL541_12670 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AL541_12680 ENOG4105D0M Protease HtpX homolog AL541_12690 ENOG4107FW0 short-chain dehydrogenase reductase AL541_12705 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AL541_12715 ENOG4105RHG AL541_12725 ENOG4107QTF adenylosuccinate lyase AL541_12730 ENOG41075W9 High frequency lysogenization protein HflD homolog AL541_12735 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AL541_12745 ENOG4107RE1 Inosine-guanosine kinase AL541_12750 ENOG4108YX2 DNA-binding protein AL541_12755 ENOG4107S6Z Na H antiporter AL541_12760 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AL541_12765 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AL541_12770 ENOG4105CIH Imidazole acetol-phosphate transaminase AL541_12800 ENOG4105K5B UPF0225 protein AL541_12805 ENOG4105D58 Diguanylate phosphodiesterase AL541_12810 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AL541_12815 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL541_12820 ENOG4105C8N cysteinyl-tRNA synthetase AL541_12825 ENOG4107104 thymidine kinase AL541_12830 ENOG4107DB1 DUF218 domain AL541_12855 ENOG4105TMB Formate nitrite transporter AL541_12880 ENOG4108J2R molybdopterin oxidoreductase AL541_12895 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AL541_12905 ENOG4108JQ2 peptide transport system atp-binding protein AL541_12910 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AL541_12915 ENOG4108EU3 peptide transport system, permease AL541_12920 ENOG4108I5W peptide transport system, permease protein AL541_12925 ENOG4108J59 Extracellular solute-binding protein, family 5 AL541_12930 ENOG4105E51 psp operon transcriptional activator AL541_12935 ENOG41087YS Phage shock protein A AL541_12940 ENOG4105YYT phage shock protein B AL541_12945 ENOG4105FM1 phage shock protein C AL541_12965 ENOG4108R3E Dna-3-methyladenine glycosylase i AL541_12975 ENOG4107IFA Lipase (EC 3.1.1.3) AL541_12980 ENOG4105C28 cystathionine AL541_12985 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AL541_12990 ENOG4105C8J )-transporter AL541_12995 ENOG4108W1A pseudouridine synthase AL541_13005 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL541_13010 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AL541_13015 ENOG4108JUA Transcriptional regulator AL541_13030 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AL541_13035 ENOG4108VGW abc transporter atp-binding protein AL541_13040 ENOG4105CXZ ABC transporter, permease AL541_13045 ENOG4105VNH ABC transporter solute-binding protein AL541_13055 ENOG4105XZD Fe-S protein AL541_13070 ENOG4105CGH 5'-nucleotidase AL541_13080 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AL541_13085 ENOG4105EB3 Histidine kinase AL541_13090 ENOG4105ETX regulatoR AL541_13100 ENOG4105CFI type iii restriction protein res subunit AL541_13105 ENOG4105I08 Pseudouridine synthase AL541_13115 ENOG4105C2C drug resistance transporter, Bcr CflA AL541_13125 ENOG4105CGD Nad-dependent epimerase dehydratase AL541_13130 ENOG4107QI1 Mate efflux family protein AL541_13150 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AL541_13160 ENOG41067SE Tetr family transcriptional regulator AL541_13165 ENOG4107QPN acyl-Coa dehydrogenase AL541_13170 ENOG4105RKW reductase (By AL541_13175 ENOG4105D0C transport protein AL541_13180 ENOG41090BQ Glutaredoxin AL541_13190 ENOG4106KNT transcriptional regulator AL541_13195 ENOG4105DY8 decarboxylase AL541_13205 ENOG4105DWU Membrane AL541_13240 ENOG4105BZU Histidine kinase AL541_13250 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AL541_13255 ENOG4105BZC d-serine deaminase AL541_13260 ENOG4108JJ8 (ABC) transporter AL541_13265 ENOG4108JJ9 ABC, transporter AL541_13270 ENOG4105C3M thioredoxin reductase AL541_13290 ENOG4105BZU Histidine kinase AL541_13295 ENOG4105C8P )-transporter AL541_13300 ENOG4107GZ4 SanA protein AL541_13305 ENOG4107R1I NAD-dependent malic enzyme AL541_13310 ENOG4105CQ7 ATP-dependent helicase AL541_13320 ENOG4108RS6 transposase AL541_13330 ENOG4105C8V SAICAR synthetase AL541_13350 ENOG4105CDV Ompa motb domain protein AL541_13365 ENOG4105CQB FAD linked oxidase domain protein AL541_13380 ENOG4105C84 Histidine ammonia-lyase AL541_13390 ENOG41088SP formiminoglutamate hydrolase AL541_13395 ENOG4105CI2 imidazolone-5-propionate hydrolase AL541_13400 ENOG4105CZE histidine utilization repressor AL541_13415 ENOG4105C22 threonyL-tRNA synthetase AL541_13420 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AL541_13425 ENOG41082NX 50s ribosomal protein l35 AL541_13430 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AL541_13435 ENOG4105K8R UPF0145 protein AL541_13470 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AL541_13475 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AL541_13485 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL541_13495 ENOG4105FQ6 thiopurine methyltransferase AL541_13500 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AL541_13505 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) AL541_13510 ENOG41067MG lrgb family AL541_13515 ENOG4105VAW lrga family AL541_13520 ENOG4105CJB Exodeoxyribonuclease I AL541_13525 ENOG4108ETY sodium dicarboxylate symporter AL541_13530 ENOG4105K4T epimerase AL541_13535 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AL541_13540 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AL541_13560 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AL541_13565 ENOG4108IU2 vtamin B12-transporter permease AL541_13570 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AL541_13590 ENOG4105F04 LysR family Transcriptional regulator AL541_13600 ENOG4108VKG metal-dependent hydrolase AL541_13605 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AL541_13635 ENOG4105CTU Proline racemase AL541_13650 ENOG4105CIF Ornithine Cyclodeaminase AL541_13655 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL541_13660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL541_13665 ENOG4105F38 ABC transporter, permease AL541_13670 ENOG4105D38 putrescine abc transporter AL541_13680 ENOG4107MM9 BNR Asp-box repeat-containing protein AL541_13690 ENOG4108JQ7 (ABC) transporter AL541_13695 ENOG4105C3U ABC transporter AL541_13700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL541_13705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL541_13710 ENOG4107QSI ABC, transporter AL541_13715 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL541_13720 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AL541_13725 ENOG4105F1J Homogentisate 1,2-dioxygenase AL541_13735 ENOG4108RXX maleylacetoacetate isomerase AL541_13895 ENOG4105KK4 UPF0060 membrane protein AL541_13910 ENOG4107S6Z Na H antiporter AL541_13915 ENOG4105CFQ glutamine synthetase AL541_13925 ENOG4108Z86 Glutamine amidotransferase AL541_13930 ENOG4107VRI Transcriptional regulator AL541_13935 ENOG4105C26 Dehydrogenase AL541_13940 ENOG4105CJP fad dependent oxidoreductase AL541_13950 ENOG4105DWY Agmatine deiminase AL541_13955 ENOG4105C26 Dehydrogenase AL541_13960 ENOG4108JPW Aminotransferase AL541_13965 ENOG4105BZU Histidine kinase AL541_13975 ENOG4108ZT1 Transcriptional regulator AL541_13980 ENOG4105MSB protein, conserved in bacteria AL541_14005 ENOG4105BZU Histidine kinase AL541_14010 ENOG4105BZU Histidine kinase AL541_14020 ENOG41090FY type IV pilus biogenesis stability protein PilW AL541_14025 ENOG4105CVG Homoserine O-transsuccinylase AL541_14040 ENOG4105D1S lipid A biosynthesis AL541_14045 ENOG4105CTD carboxy-peptidase AL541_14080 ENOG4107TII Recombinase AL541_14120 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AL541_14125 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AL541_14175 ENOG4107NPW Protein of unknown function (DUF1524) AL541_14190 ENOG4107RRE RNA-directed DNA polymerase AL541_14215 ENOG4108KHX Diguanylate cyclase AL541_14260 ENOG4105CTD carboxy-peptidase AL541_14265 ENOG410829K Lysine exporter protein (Lyse ygga) AL541_14275 ENOG4105BZG amino acid carrier protein AL541_14300 ENOG4105E0M Sulfatase AL541_14305 ENOG4105GIJ Glycine betaine AL541_14310 ENOG4108HQS Glycine betaine AL541_14315 ENOG4108IJ7 Glycine betaine AL541_14330 ENOG4105C94 Transporter AL541_14335 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase AL541_14340 ENOG4108JPW Aminotransferase AL541_14345 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AL541_14350 ENOG4105CZK Aspartate kinase AL541_14355 ENOG4105ENH Sulfatase AL541_14370 ENOG4105C4X radical SAM domain protein AL541_14385 ENOG4105ENH Sulfatase AL541_14390 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AL541_14410 ENOG4105DFG type I secretion outer membrane protein AL541_14425 ENOG4105E98 transcriptional regulator DeoR family AL541_14430 ENOG4105D9R oxidoreductase AL541_14435 ENOG41090KN UPF0303 protein AL541_14440 ENOG4105BZU Histidine kinase AL541_14460 ENOG4105C8P )-transporter AL541_14470 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_14475 ENOG4105BZU Histidine kinase AL541_14480 ENOG4105CPI Metal Dependent Phosphohydrolase AL541_14485 ENOG410829K Lysine exporter protein (Lyse ygga) AL541_14490 ENOG4105G0K glycine radical enzyme YjjI family AL541_14495 ENOG41076CZ activating enzyme AL541_14505 ENOG4105EE5 Membrane protein terC AL541_14515 ENOG4105DHT Metal Dependent Phosphohydrolase AL541_14525 ENOG4105E0U tyrosine-specific transport protein AL541_14530 ENOG4105CPI Metal Dependent Phosphohydrolase AL541_14540 ENOG4105E0A ABC, transporter AL541_14545 ENOG4105J76 Periplasmic binding protein AL541_14550 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL541_14555 ENOG4105E0K tonB-dependent siderophore receptor AL541_14565 ENOG4105BZ1 (ABC) transporter AL541_14570 ENOG4105BZ1 (ABC) transporter AL541_14575 ENOG4108VAU general secretion pathway protein G AL541_14585 ENOG4105CR8 Transcriptional regulator AL541_14610 ENOG4105CFG Acts as a chaperone (By similarity) AL541_14615 ENOG4105CFG Acts as a chaperone (By similarity) AL541_14660 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AL541_14665 ENOG4105CQ7 ATP-dependent helicase AL541_14680 ENOG4105C94 Transporter AL541_14695 ENOG4107R8N Glycosyl transferase, family 2 AL541_14700 ENOG4105CPK Glycosyl transferase (Group 1 AL541_14730 ENOG4107TYR Glycosyl Transferase AL541_14740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_14755 ENOG4107V1M polysaccharide export protein AL541_14765 ENOG41082AN stage II sporulation protein AL541_14780 ENOG4107QI1 Mate efflux family protein AL541_14785 ENOG4108R6K riboflavin synthase, subunit alpha AL541_14795 ENOG4105FGM Fructosamine kinase AL541_14805 ENOG4105BZU Histidine kinase AL541_14815 ENOG4107TT5 NLP P60 protein AL541_14845 ENOG4106IUH DTW domain containing protein AL541_14850 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AL541_14860 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL541_14865 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AL541_14870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL541_14885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_14890 ENOG4105BZU Histidine kinase AL541_14900 ENOG4105C5H ABC transporter AL541_14905 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL541_14925 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL541_14935 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL541_14940 ENOG4105QAX Iron-sulfur AL541_15095 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AL541_15100 ENOG4107RUE extracellular solute-binding protein family 1 AL541_15105 ENOG4107RUE extracellular solute-binding protein family 1 AL541_15110 ENOG4105D38 putrescine abc transporter AL541_15115 ENOG4105F38 ABC transporter, permease AL541_15120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL541_15140 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AL541_15145 ENOG4105Q9Y Universal stress protein AL541_15150 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL541_15165 ENOG4105C59 p-type ATPase AL541_15175 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) AL541_15190 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AL541_15230 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) AL541_15235 ENOG4105DAN ATP-dependent protease AL541_15240 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AL541_15255 ENOG4105C5H ABC transporter AL541_15265 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AL541_15270 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AL541_15275 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AL541_15280 ENOG4105C7I Dehydrogenase AL541_15290 ENOG4105CD8 aminopeptidase N AL541_15300 ENOG4105CN1 protease AL541_15305 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AL541_15310 ENOG4108ZGC gaf domain protein AL541_15315 ENOG4105BZ1 (ABC) transporter AL541_15320 ENOG4105H2K paraquat-inducible protein a AL541_15325 ENOG4105DY2 Paraquat-inducible protein b AL541_15330 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL541_15350 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL541_15355 ENOG4108VPT UPF0234 protein AL541_15370 ENOG4107QXX ABC transporter AL541_15375 ENOG4105EZ7 amino acid ABC transporter AL541_15380 ENOG4105DRP amino acid AbC transporter AL541_15385 ENOG4105CDA abc transporter atp-binding protein AL541_15390 ENOG4108MN8 Membrane AL541_15400 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AL541_15405 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AL541_15410 ENOG4105C8Q Methyl-accepting chemotaxis AL541_15415 ENOG4105DR4 Methyltransferase AL541_15430 ENOG4105KCK Peptidoglycan-associated lipoprotein AL541_15455 ENOG4105CDV Ompa motb domain protein AL541_15465 ENOG410620I Diguanylate cyclase AL541_15470 ENOG4107HP6 Transcriptional regulator AL541_15480 ENOG4105CV8 reductase AL541_15485 ENOG4105HEI LysR family (Transcriptional regulator AL541_15495 ENOG4105HEI LysR family (Transcriptional regulator AL541_15500 ENOG4105F27 Major Facilitator AL541_15515 ENOG41063TF transcriptional regulator (AraC AL541_15520 ENOG4108W2Y isochorismatase AL541_15525 ENOG4106PMH Extracellular solute-binding protein family 3 AL541_15535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AL541_15540 ENOG4105C3R Methionine synthase AL541_15545 ENOG4105CDA abc transporter atp-binding protein AL541_15550 ENOG4105EAD ABC transporter AL541_15555 ENOG4106PMH Extracellular solute-binding protein family 3 AL541_15570 ENOG4105CC0 LysR family Transcriptional regulator AL541_15585 ENOG4105HEI LysR family (Transcriptional regulator AL541_15595 ENOG41090KR LysR family transcriptional Regulator AL541_15610 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AL541_15615 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AL541_15620 ENOG410667J hydrolase AL541_15630 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AL541_15640 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL541_15645 ENOG4105C7F AcnD-accessory protein PrpF AL541_15650 ENOG4108I0Z Aconitate hydratase AL541_15655 ENOG4105BZN citrate synthase AL541_15660 ENOG4105CR4 methylisocitrate lyase AL541_15695 ENOG4105EJ9 Membrane AL541_15810 ENOG4105E7U AraC family transcriptional regulator AL541_15880 ENOG41066XE Type III export protein AL541_15910 ENOG4108KB1 transcriptional regulator, arac family AL541_15930 ENOG4105C26 Dehydrogenase AL541_15935 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AL541_15950 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AL541_15955 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) AL541_15960 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AL541_15975 ENOG4106YYS transcriptional regulatory protein AL541_15980 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AL541_15995 ENOG4107KET secretion protein, HlyD family AL541_16010 ENOG4105DUM transcriptional regulator, lysR family AL541_16030 ENOG4105CEB Aspartate aminotransferase AL541_16035 ENOG4105D0C transport protein AL541_16045 ENOG4105Y49 secretion protein, HlyD family AL541_16060 ENOG4105EBR Carboxylesterase AL541_16065 ENOG4107RZC phospholipase d AL541_16070 ENOG4105CFU surface antigen AL541_16075 ENOG41090VV Protein of unknown function (DUF2846) AL541_16080 ENOG4105N14 lysine exporter protein LysE YggA AL541_16090 ENOG4105KCV RNA signal recognition particle 4.5S RNA AL541_16110 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL541_16115 ENOG41068WN AL541_16120 ENOG4108UW5 maltose o-acetyltransferase AL541_16230 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AL541_16715 ENOG4105D3W isochorismatase AL541_16845 ENOG4105N14 lysine exporter protein LysE YggA AL541_16915 ENOG4105YGK Pfam:UPF0157 AL541_17010 ENOG4105WDY DNA (cytosine-5-)-methyltransferase AL541_17100 ENOG410822N TonB family AL541_17185 ENOG4105K4H Nlp p60 protein AL541_17215 ENOG4105K4U addiction module toxin, RelE StbE family AL541_17275 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AL541_17325 ENOG4108TSE Transferase AL541_17335 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL541_17340 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AL541_17345 ENOG4105E4F Isochorismate synthase AL541_17350 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AL541_17355 ENOG4105WQI isochorismatase AL541_17360 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein AL541_17370 ENOG4105DQ5 transport system permease protein AL541_17375 ENOG4105TVJ transport system, permease AL541_17380 ENOG4105E0A ABC, transporter AL541_17395 ENOG4105E93 esterase AL541_17400 ENOG4107RBR Receptor AL541_17420 ENOG4105IJJ transcriptional regulator, crp fnr family AL541_17435 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL541_17530 ENOG4105D3W isochorismatase AL541_17765 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL541_17920 ENOG4105D9U N-acetyltransferase AL541_17930 ENOG4106K28 UPF0283 membrane protein AL541_17935 ENOG4105CM6 amino acid regulated cytosolic protein AL541_17955 ENOG4105CRQ synthase (Component I) AL541_17970 ENOG4105P8F nudix hydrolase AL541_17975 ENOG4105C44 Serine transporter AL541_17980 ENOG4105EJQ L-serine dehydratase AL541_17985 ENOG4105BZU Histidine kinase AL541_17995 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AL541_18000 ENOG4105C8Q Methyl-accepting chemotaxis AL541_18005 ENOG4105C5S asparaginyl-tRNA synthetase AL541_18015 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL541_18030 ENOG4105CGF Aromatic amino acid aminotransferase AL541_18050 ENOG4105C8Q Methyl-accepting chemotaxis AL541_18055 ENOG4105C94 Transporter AL541_18075 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL541_18085 ENOG4105CH5 extracellular solute-binding protein, family 7 AL541_18100 ENOG4105C5X domain protein AL541_18105 ENOG4105EAQ (twin-arginine translocation) pathway signal AL541_18110 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AL541_18135 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AL541_18145 ENOG4108DMF Cytochrome C biogenesis protein AL541_18150 ENOG4107QX9 Thiol disulfide interChange protein AL541_18155 ENOG4105DA4 cytochrome c-type biogenesis protein AL541_18160 ENOG4105DVI reductase, NrfD AL541_18165 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL541_18175 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AL541_18190 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL541_18195 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL541_18205 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL541_18210 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL541_18235 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) AL541_18275 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AL541_18280 ENOG4105WH1 Two component transcriptional regulator luxr family AL541_18285 ENOG4105CQ2 DNA polymerase AL541_18300 ENOG4108W5H UPF0263 protein AL541_18305 ENOG4105FE9 pseudouridine synthase AL541_18315 ENOG4107RTD sua5 ycio yrdc ywlc family protein AL541_18320 ENOG4105DB7 PHP domain protein AL541_18330 ENOG4105CRQ synthase (Component I) AL541_18335 ENOG4105DDQ anthranilate synthase AL541_18340 ENOG4108I0Q anthranilate phosphoribosyltransferase AL541_18345 ENOG4105DK0 Indole-3-glycerol phosphate synthase AL541_18350 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL541_18355 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AL541_18360 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL541_18365 ENOG4105CEY Amp-dependent synthetase and ligase AL541_18375 ENOG4105CK2 sodium dicarboxylate symporter AL541_18385 ENOG4105BZU Histidine kinase AL541_18395 ENOG4107835 probably involved in intracellular septation (By similarity) AL541_18400 ENOG4105NAU thioesterase Superfamily protein AL541_18405 ENOG4105K9H YciI-like protein AL541_18415 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL541_18420 ENOG4105DZ2 Transcriptional regulator AL541_18440 ENOG4105CCT upf0313 protein AL541_18460 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AL541_18470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL541_18475 ENOG41062D9 Histidine kinase AL541_18495 ENOG4105JQN Transcriptional regulator AL541_18500 ENOG4105J12 Multidrug resistance protein mdtN AL541_18510 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL541_18530 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL541_18540 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL541_18550 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL541_18570 ENOG4105N6Y Thioredoxin AL541_18575 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL541_18585 ENOG4108ZXC Two component transcriptional regulator, luxr family AL541_18590 ENOG4106AFQ Histidine kinase AL541_18595 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL541_18600 ENOG4106WHD Tetrathionate reductase AL541_18605 ENOG4105DB1 molybdopterin oxidoreductase AL541_18615 ENOG4105NQN cytochrome C AL541_18620 ENOG4105F1S paraquat-inducible protein a AL541_18625 ENOG4105DY2 Paraquat-inducible protein b AL541_18645 ENOG4108J59 Extracellular solute-binding protein, family 5 AL541_18650 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AL541_18655 ENOG4105CFV Tetratricopeptide repeat protein AL541_18660 ENOG4105Q4A inner membrane protein yciS AL541_18665 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL541_18670 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AL541_18675 ENOG4105CAT Cytidine monophosphate kinase AL541_18680 ENOG4105ERU peptidase AL541_18685 ENOG4105UBK short-chain dehydrogenase reductase AL541_18700 ENOG4105C0B DNA polymerase III (alpha subunit) AL541_18705 ENOG4107R88 Chemotaxis protein (CheV) AL541_18710 ENOG4105DAG ROK family AL541_18715 ENOG4105CA9 Pyruvate kinase AL541_18720 ENOG4108NRW Phospholipase, patatin family AL541_18735 ENOG4105C8J )-transporter AL541_18745 ENOG4105CI1 PTS System AL541_18750 ENOG4105F8V Hydrolase, tatD family AL541_18755 ENOG4107QRG dna polymerase iii AL541_18760 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AL541_18765 ENOG4105HHA aminodeoxychorismate lyase AL541_18775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL541_18780 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL541_18785 ENOG4105CHR reductase AL541_18790 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AL541_18795 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL541_18800 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AL541_18805 ENOG4105VGS 50s ribosomal protein l32 AL541_18810 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AL541_18815 ENOG4108UHJ MAF-like protein AL541_18820 ENOG4105EI2 Pseudouridine synthase AL541_18830 ENOG4105C03 ribonuclease AL541_18840 ENOG4105CHH sulfate transporter AL541_18850 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AL541_18860 ENOG4105DBI uridine monophosphokinase AL541_18865 ENOG4105D1F ATP-binding protein AL541_18870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AL541_18890 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AL541_18900 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AL541_18905 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL541_18910 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AL541_18915 ENOG4105BZU Histidine kinase AL541_18920 ENOG4107R28 alpha amylase, catalytic region AL541_18925 ENOG4108JJB ABC transporter AL541_18930 ENOG4105C7J ABC transporter, permease AL541_18940 ENOG4105PQ6 UPF0208 membrane protein AL541_18945 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL541_18950 ENOG4108DNC Involved in acetate metabolism (By similarity) AL541_18960 ENOG4105CHF Glutathione S-transferase AL541_18965 ENOG4108JQ7 (ABC) transporter AL541_18970 ENOG4105C3U ABC transporter AL541_18975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL541_18980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL541_18985 ENOG4107QSI ABC, transporter AL541_18990 ENOG4108ZAF Molybdopterin AL541_18995 ENOG4105M00 molybdopterin converting factor, subunit 1 AL541_19000 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL541_19005 ENOG4108RIR Molybdenum cofactor biosynthesis protein AL541_19010 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL541_19015 ENOG4105CHW UPF0052 protein AL541_19025 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_19030 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AL541_19040 ENOG4105C6N Formate acetyltransferase AL541_19045 ENOG4105DGN Electron transport complex AL541_19050 ENOG4108R3D Electron transport complex AL541_19060 ENOG4105D6A Electron transport complex AL541_19065 ENOG4108UQQ Electron transport complex AL541_19070 ENOG4105DZB Electron transport complex AL541_19075 ENOG4105CSM endonuclease III AL541_19080 ENOG4108UYE Lactoylglutathione lyase AL541_19085 ENOG4106WH9 Protein of unknown function (DUF2753) AL541_19090 ENOG4105EIY sodium-type flagellar protein motY AL541_19100 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AL541_19105 ENOG4105D3Y Na H antiporter AL541_19125 ENOG4105M2J Glutaredoxin AL541_19130 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL541_19150 ENOG4108EKI Dehydrogenase AL541_19155 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AL541_19160 ENOG4105EYW Ion transport protein AL541_19165 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL541_19170 ENOG4105DFD Na H antiporter AL541_19185 ENOG4106V8H Nucleoid-associated protein AL541_19190 ENOG4105YDX UPF0352 protein AL541_19195 ENOG4105E68 Sulfatase AL541_19205 ENOG4105DGU Histone deacetylase AL541_19210 ENOG4108RU0 short-chain dehydrogenase reductase AL541_19220 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL541_19225 ENOG41069NU Nitroreductase AL541_19235 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL541_19240 ENOG4105D07 Signal peptide peptidase, SppA AL541_19245 ENOG4105HDK L-asparaginase AL541_19250 ENOG4105VUT cytoplasmic protein AL541_19260 ENOG4105E0X reductase AL541_19265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL541_19270 ENOG4105DSB aldose 1-epimerase AL541_19275 ENOG4107SDU Methyl-accepting chemotaxis AL541_19280 ENOG4105DHI Methyltransferase AL541_19300 ENOG4105G6Z alkaline phosphatase AL541_19315 ENOG41067V3 Antibiotic biosynthesis monooxygenase AL541_19325 ENOG4108ZZ3 UPF0260 protein AL541_19330 ENOG4105Y3U Transglycosylase-associated protein AL541_19335 ENOG4105KRS Proteinase inhibitor AL541_19340 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL541_19345 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AL541_19350 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AL541_19355 ENOG4107QMP dna polymerase iii subunits gamma and tau AL541_19360 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AL541_19365 ENOG4105WD1 Membrane AL541_19375 ENOG4105I93 response regulator AL541_19380 ENOG4105EJC lysr family transcriptional regulator AL541_19385 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AL541_19390 ENOG4105E96 Colicin v production protein AL541_19395 ENOG4108S3P Sporulation domain protein AL541_19400 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AL541_19405 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AL541_19415 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AL541_19425 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL541_19430 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AL541_19440 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL541_19445 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AL541_19450 ENOG4105Q8W reductase AL541_19460 ENOG4105MH2 YfcL protein AL541_19465 ENOG4108BPE -transporting atpase AL541_19475 ENOG4105EN6 Membrane AL541_19480 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AL541_19485 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AL541_19490 ENOG4108DG9 Smr protein MutS2 AL541_19495 ENOG4108BY2 phosphohistidine phosphatase AL541_19500 ENOG4107QXK peptidase AL541_19510 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL541_19515 ENOG4105CHU acetyl-coa acetyltransferase AL541_19535 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL541_19540 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL541_19545 ENOG410903C (LipO)protein AL541_19550 ENOG4105KWW Biogenesis protein AL541_19555 ENOG4108M1T Cytochrome c-type biogenesis protein AL541_19560 ENOG4107QX9 Thiol disulfide interChange protein AL541_19565 ENOG4105DA4 cytochrome c-type biogenesis protein AL541_19570 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AL541_19575 ENOG4105X3C heme exporter protein AL541_19580 ENOG41060IM Heme exporter protein AL541_19585 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AL541_19590 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AL541_19600 ENOG4108V3W Chemotaxis protein, CheW AL541_19610 ENOG4107QJE Chromosome Partitioning Protein AL541_19615 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AL541_19620 ENOG4105CBS Chea signal transduction histidine kinase AL541_19625 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AL541_19630 ENOG4108VYJ response regulator receiver protein AL541_19635 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL541_19640 ENOG4107R21 site-determining protein AL541_19645 ENOG4105FZW flagellar biosynthesis regulator FlhF AL541_19650 ENOG4105D7B Flagellar biosynthesis protein flha AL541_19655 ENOG4105D00 flagellar biosynthetic protein flhB AL541_19660 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL541_19665 ENOG4105VS8 Flagellar biosynthetic protein fliq AL541_19670 ENOG4105CN7 Flagellar biosynthetic protein FliP AL541_19675 ENOG4105VTB flagellar biosynthesis protein fliO AL541_19680 ENOG4105DD5 Flagellar motor switch protein AL541_19685 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL541_19710 ENOG4108JIR Flagellum-specific ATP synthase AL541_19720 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL541_19725 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL541_19730 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AL541_19735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_19740 ENOG4105BZU Histidine kinase AL541_19745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_19750 ENOG4105MQ3 flagellar protein FliS AL541_19760 ENOG4107BRV flagellar capping protein AL541_19765 ENOG41063QE flagellar protein FlaG AL541_19770 ENOG4105I03 Flagellin AL541_19775 ENOG4105I03 Flagellin AL541_19785 ENOG4105I03 Flagellin AL541_19790 ENOG4105EZR dyp-type peroxidase family protein AL541_19795 ENOG4105QZU Inner membrane protein YfeZ AL541_19815 ENOG4105KUZ arsenate reductase AL541_19820 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL541_19835 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL541_19850 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL541_19865 ENOG4105ERG peptidase m48, ste24p AL541_19870 ENOG4105K89 arsenate reductase AL541_19875 ENOG4105CS1 NAD(P)H quinone oxidoreductase AL541_19890 ENOG4105C2W permease AL541_19900 ENOG4105CXB phosphoribosylaminoimidazole synthetase AL541_19905 ENOG4108V3E phosphoribosylglycinamide formyltransferase AL541_19910 ENOG4105E7A Glutamine amidotransferase AL541_19915 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL541_19920 ENOG4107QPN acyl-Coa dehydrogenase AL541_19950 ENOG4108JDX DNA polymerase iii, epsilon subunit AL541_19955 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL541_19960 ENOG4105D1A Methyltransferase AL541_19965 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AL541_19970 ENOG4105E9H Lytic Murein transglycosylase AL541_19980 ENOG4107NA1 Endonuclease Exonuclease phosphatase AL541_19985 ENOG4108YZA Nitrogen regulatory protein pii AL541_19990 ENOG4105N7H Cytochrome AL541_19995 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AL541_20000 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AL541_20005 ENOG4105C0B DNA polymerase III (alpha subunit) AL541_20010 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL541_20015 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL541_20020 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL541_20025 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL541_20030 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL541_20035 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AL541_20045 ENOG4105DZP Membrane-associated zinc metalloprotease AL541_20050 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AL541_20055 ENOG4105KNE Phosphatidate cytidylyltransferase AL541_20060 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AL541_20065 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AL541_20070 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AL541_20075 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AL541_20080 ENOG4105CE9 30S ribosomal protein S2 AL541_20085 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AL541_20090 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AL541_20095 ENOG4108T8E UPF0325 protein AL541_20100 ENOG4105DR9 pseudouridine synthase AL541_20105 ENOG4105WP7 tRNA pseudouridine synthase C AL541_20135 ENOG4108UPT UPF0178 protein AL541_20140 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL541_20145 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AL541_20170 ENOG4105CFC Transporter AL541_20180 ENOG4105NRA 50s ribosomal protein l31 type b AL541_20185 ENOG4108R96 Methyltransferase, YaeB family AL541_20190 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AL541_20200 ENOG4105W1I UPF0253 protein AL541_20210 ENOG4105C8J )-transporter AL541_20225 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL541_20230 ENOG4105C9U ATP-dependent DNA helicase RecQ AL541_20235 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AL541_20245 ENOG4105BZU Histidine kinase AL541_20255 ENOG4105CJ2 (LipO)protein AL541_20260 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AL541_20265 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL541_20270 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL541_20275 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL541_20280 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL541_20285 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL541_20295 ENOG4105M85 Bola protein AL541_20300 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL541_20305 ENOG4105IEY (LipO)protein AL541_20310 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL541_20325 ENOG4105K6V RNA polymerase AL541_20350 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AL541_20355 ENOG4107S0N DJ-1 family AL541_20360 ENOG4105C9B Cysteine desulfurase AL541_20365 ENOG4105BZU Histidine kinase AL541_20370 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AL541_20375 ENOG4105CUZ uba thif-type nad fad binding protein AL541_20380 ENOG4105CA3 membrane-bound lytic murein transglycosylase AL541_20395 ENOG4107QZM n-acetylglutamate synthase AL541_20415 ENOG4107QYX exodeoxyribonuclease v alpha AL541_20420 ENOG4107QKA exodeoxyribonuclease V beta AL541_20430 ENOG4105DSY exodeoxyribonuclease V, gamma AL541_20435 ENOG4105E68 Sulfatase AL541_20445 ENOG4105EVZ LysR family transcriptional regulator AL541_20450 ENOG4105X2V dna damage-inducible protein AL541_20465 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AL541_20470 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AL541_20475 ENOG4105CXY transporter AL541_20485 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL541_20490 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AL541_20495 ENOG4105E98 transcriptional regulator DeoR family AL541_20500 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AL541_20505 ENOG4107RX3 Mg2 transporter protein cora family protein AL541_20525 ENOG4105CQ4 Transcriptional regulator AL541_20530 ENOG41064T2 transcriptional regulator, lysR family AL541_20540 ENOG41086KC Transcriptional regulator AL541_20570 ENOG4108IQE Amp-dependent synthetase and ligase AL541_20580 ENOG4105ETT transcriptional Regulator, LysR family AL541_20585 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL541_20590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AL541_20600 ENOG4105EAC phosphoserine phosphatase AL541_20610 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL541_20615 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AL541_20620 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AL541_20625 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AL541_20630 ENOG4105D9N nucleoside AL541_20635 ENOG4105EYA deoxyribonuclease AL541_20645 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AL541_20665 ENOG4108YYD acetyltransferase AL541_20670 ENOG4105XPQ lipid carrier protein AL541_20680 ENOG4105BZU Histidine kinase AL541_20685 ENOG4105CFP Peptidase U32 AL541_20690 ENOG4106RZ4 Peptidase U32 AL541_20695 ENOG4105C3S Mate efflux family protein AL541_20710 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AL541_20715 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AL541_20720 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AL541_20725 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AL541_20730 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AL541_20735 ENOG4105CHV Transcription elongation factor NusA AL541_20740 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AL541_20765 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AL541_20770 ENOG4105EEI dihydropteroate synthase AL541_20775 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AL541_20780 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AL541_20785 ENOG4105HBR Rna-binding protein AL541_20790 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL541_20795 ENOG4107QE9 Inherit from COG: Membrane AL541_20800 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AL541_20810 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL541_20815 ENOG4105DR5 peptidase AL541_20830 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AL541_20835 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AL541_20840 ENOG4105F4G Membrane AL541_20845 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL541_20850 ENOG4105BZU Histidine kinase AL541_20855 ENOG4107QRA Extracellular solute-binding protein, family 5 AL541_20865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL541_20870 ENOG4105C3U ABC transporter AL541_20875 ENOG4108JQ7 (ABC) transporter AL541_20885 ENOG4105RD7 BadF BadG BcrA BcrD AL541_20890 ENOG4105E2D ec 3.2.1.52 AL541_20905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL541_20925 ENOG4108YZA Nitrogen regulatory protein pii AL541_20930 ENOG4105XTV UPF0231 protein AL541_20935 ENOG4107QIJ Aconitate hydratase 2 AL541_20940 ENOG4105D78 K07001 NTE family protein AL541_20945 ENOG4105BZ4 penicillin-binding protein AL541_20950 ENOG4105CQ7 ATP-dependent helicase AL541_20955 ENOG4105PW4 Sugar fermentation stimulation protein homolog AL541_20960 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AL541_20965 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AL541_20970 ENOG4105DJ0 Poly(A) Polymerase AL541_20975 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL541_20980 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AL541_20985 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AL541_20990 ENOG4105D1S lipid A biosynthesis AL541_21000 ENOG4105E3A (ABC) transporter AL541_21005 ENOG4105DA5 (ABC) transporter AL541_21010 ENOG4105CHH sulfate transporter AL541_21015 ENOG41077A9 carbonic anhydrase AL541_21020 ENOG4108UGV hypoxanthine phosphoribosyltransferase AL541_21025 ENOG410630P Transcriptional regulator AL541_21030 ENOG4107QN2 dihydrolipoyl dehydrogenase AL541_21035 ENOG4107QSN dihydrolipoamide acetyltransferase AL541_21040 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AL541_21045 ENOG41073TP transcriptional regulator AL541_21055 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AL541_21065 ENOG4107QHF type ii secretion system protein e AL541_21070 ENOG4105D7Q type ii secretion system AL541_21075 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AL541_21080 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AL541_21085 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AL541_21090 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AL541_21095 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AL541_21100 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AL541_21105 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AL541_21110 ENOG4105K5M 30s ribosomal protein S16 AL541_21115 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AL541_21120 ENOG4106KVJ cytochrome C assembly protein AL541_21125 ENOG4108JU6 CBS domain protein AL541_21140 ENOG4105D9M gamma-glutamylcysteine synthetase AL541_21150 ENOG4105W39 Membrane AL541_21160 ENOG4105D9Q decarboxylase (Beta subunit) AL541_21165 ENOG4107QSA Oxaloacetate decarboxylase AL541_21225 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AL541_21230 ENOG4105CFH Aspartokinase AL541_21235 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL541_21240 ENOG4105Y3E Modulates RecA activity (By similarity) AL541_21245 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AL541_21250 ENOG4107TH8 cina domain protein AL541_21255 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AL541_21260 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL541_21270 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AL541_21275 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AL541_21280 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AL541_21285 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AL541_21290 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AL541_21295 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL541_21300 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AL541_21305 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AL541_21310 ENOG4105DXN mazG family AL541_21315 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL541_21325 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AL541_21335 ENOG4105BZU Histidine kinase AL541_21340 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AL541_21345 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AL541_21350 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AL541_21355 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AL541_21360 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AL541_21365 ENOG4105C3F Signal peptidase i AL541_21370 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AL541_21390 ENOG4105EMN RNA polymerase sigma factor AL541_21400 ENOG4108IYU L-aspartate oxidase AL541_21410 ENOG4105Y75 tpr repeat protein AL541_21415 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AL541_21430 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL541_21435 ENOG4105D0A hydroxylase AL541_21450 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AL541_21460 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AL541_21465 ENOG4105E66 phosphoriboisomerase A AL541_21470 ENOG4108JQ1 Dehydrogenase AL541_21475 ENOG4105MPN Membrane AL541_21480 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AL541_21495 ENOG4105D64 Mechanosensitive ion channel AL541_21500 ENOG4105D2N Aldolase AL541_21505 ENOG4105BZA Phosphoglycerate kinase AL541_21510 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL541_21515 ENOG4105D05 Receptor AL541_21520 ENOG4108R4R Iron-regulated virulence regulatory protein AL541_21525 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL541_21535 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AL541_21545 ENOG4105GPY SprT protein AL541_21550 ENOG4105RWS endonuclease I AL541_21555 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AL541_21560 ENOG4105D7Z glutathione synthase AL541_21565 ENOG4108UJU UPF0301 protein AL541_21570 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AL541_21575 ENOG4105CZX twitching motility protein AL541_21580 ENOG4105CZX twitching motility protein AL541_21585 ENOG4105DFA alanine racemase domain protein AL541_21590 ENOG4105II7 pyrroline-5-carboxylate reductase AL541_21595 ENOG4108VIA integral membrane protein AL541_21600 ENOG4105VZ9 UPF0235 protein AL541_21610 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL541_21615 ENOG4105CSA Coproporphyrinogen iii oxidase AL541_21620 ENOG4105CSV Glutaminase AL541_21630 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AL541_21635 ENOG4105CEN a g-specific adenine glycosylase AL541_21640 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AL541_21685 ENOG4105C8Q Methyl-accepting chemotaxis AL541_21765 ENOG4108ESY Metal dependent phosphohydrolase AL541_21770 ENOG4105ETE Transcriptional regulator (LacI family AL541_21775 ENOG410901P UPF0249 protein AL541_21780 ENOG4105F8D glycoside hydrolase family 4 AL541_21785 ENOG4105VCP PTS System AL541_21790 ENOG4105CK1 PTS System AL541_21895 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL541_21900 ENOG4105EXU Membrane AL541_21910 ENOG4108K5H permease YjgP YjgQ family protein AL541_21915 ENOG4108M8S permease YjgP YjgQ family protein AL541_21920 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AL541_21925 ENOG4105MYG DNA polymerase iii, chi subunit AL541_21930 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AL541_21940 ENOG4108MJ3 acetyltransferase AL541_21955 ENOG4105CEU Arginine dihydrolase AL541_21960 ENOG4105DBV ornithine carbamoyltransferase AL541_21970 ENOG4105CXT aspartate transcarbamylase AL541_21975 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AL541_21980 ENOG4105KME endoribonuclease L-psp AL541_21985 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AL541_21990 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AL541_21995 ENOG4105VFK BolA family AL541_22005 ENOG4105E3I toluene tolerance AL541_22010 ENOG4107PE3 Mammalian cell entry related domain protein AL541_22015 ENOG4105CY3 ABC transporter, permease AL541_22020 ENOG4105DHJ ABC, transporter AL541_22030 ENOG4105C2X Arabinose 5-phosphate isomerase AL541_22040 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AL541_22045 ENOG4108IUZ ABC transporter AL541_22050 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL541_22055 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AL541_22060 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AL541_22065 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AL541_22070 ENOG41080Z8 PHOSPHOCARRIER protein AL541_22075 ENOG4105CJW magnesium transporter AL541_22080 ENOG4105CMS peptidase U62, modulator of DNA gyrase AL541_22085 ENOG4105N42 UPF0307 protein AL541_22090 ENOG4105C5I Dehydrogenase AL541_22095 ENOG4105D3G Pseudouridine synthase AL541_22100 ENOG4105K3M )-transporter AL541_22105 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AL541_22110 ENOG4108IAB Phoh family AL541_22115 ENOG4105D1U peptidase U62 modulator of DNA gyrase AL541_22125 ENOG4105QD6 exported protein AL541_22130 ENOG4105C03 ribonuclease AL541_22135 ENOG4108Z03 MAF-like protein AL541_22140 ENOG4105VQ7 Rod shape-determining protein MreD AL541_22145 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AL541_22150 ENOG4105DFF Rod shape-determining protein mreb AL541_22195 ENOG4105D7Q type ii secretion system AL541_22200 ENOG4107QHF type ii secretion system protein e AL541_22235 ENOG41062P1 Diguanylate cyclase phosphodiesterase AL541_22240 ENOG4108UUM single-stranded DNA-binding protein AL541_22245 ENOG41086KC Transcriptional regulator AL541_22250 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AL541_22255 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AL541_22265 ENOG4105C5R Aminotransferase AL541_22275 ENOG4105CFH Aspartokinase AL541_22280 ENOG4105C3R Methionine synthase AL541_22285 ENOG4105EEQ Na H antiporter AL541_22345 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AL541_22350 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AL541_22355 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AL541_22375 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL541_22380 ENOG4105MYN Zinc uptake regulation protein AL541_22390 ENOG4107QP8 phosphohexose isomerase AL541_22395 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AL541_22400 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL541_22405 ENOG4105CDU Replicative dna helicase AL541_22415 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AL541_22420 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AL541_22425 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) AL541_22430 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AL541_22435 ENOG4105DJV ribulose-phosphate 3-epimerase AL541_22440 ENOG4105DFE Dna adenine methylase AL541_22450 ENOG4105D49 3-dehydroquinate synthase AL541_22455 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AL541_22460 ENOG4105E4G Type IV pilus AL541_22485 ENOG4108JQC penicillin-binding protein 1A AL541_22490 ENOG4105C5Q Transcriptional regulator AL541_22495 ENOG4105EHV domain protein AL541_22500 ENOG4107QN2 dihydrolipoyl dehydrogenase AL541_22510 ENOG4105CH7 arginosuccinase AL541_22515 ENOG4105CDH Citrulline--aspartate ligase AL541_22520 ENOG4105CAS nag kinase AL541_22525 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AL541_22530 ENOG4105CWC Acetylornithine deacetylase AL541_22535 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AL541_22545 ENOG4105SYT Methylenetetrahydrofolate reductase AL541_22550 ENOG4105CFH Aspartokinase AL541_22555 ENOG4105C28 cystathionine AL541_22560 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AL541_22565 ENOG4105C6K Malic enzyme AL541_22570 ENOG4108UQY Iron-storage protein AL541_22575 ENOG4105W53 bacterioferritin-associated ferredoxin AL541_22580 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL541_22585 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL541_22590 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AL541_22595 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AL541_22605 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AL541_22610 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AL541_22615 ENOG4105WWK YheO domain protein AL541_22620 ENOG4108V1T peptidylprolyl cis-trans isomerase AL541_22630 ENOG41069P5 Protein slyX homolog AL541_22635 ENOG4105D44 asparaginase AL541_22645 ENOG4108YZY peptidylprolyl cis-trans isomerase AL541_22660 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL541_22665 ENOG4105C5H ABC transporter AL541_22675 ENOG4105DNZ Alpha Beta Hydrolase AL541_22680 ENOG4105YP7 UPF0270 protein AL541_22685 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AL541_22690 ENOG4107RYR Transcriptional regulator, Crp Fnr family AL541_22700 ENOG4105C26 Dehydrogenase AL541_22710 ENOG4105C8Y Acetylornithine aminotransferase AL541_22715 ENOG4105DDQ anthranilate synthase AL541_22730 ENOG4105C31 Tryptophanyl-tRNA synthetase AL541_22735 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL541_22740 ENOG4105C2N RNA methyltransferase TrmH family group 3 AL541_22745 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AL541_22750 ENOG4105KPV Transcriptional regulator AL541_22755 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL541_22760 ENOG4108UV7 flagellar protein motX AL541_22770 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL541_22780 ENOG4105EPW hflc protein AL541_22785 ENOG4107QJR hflk protein AL541_22790 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AL541_22795 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AL541_22800 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AL541_22805 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AL541_22810 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AL541_22815 ENOG4105K8N protein family UPF0079, ATPase AL541_22825 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AL541_22890 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AL541_22895 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL541_22900 ENOG4105DJ4 phosphatidylserine decarboxylase AL541_22905 ENOG4105C8P )-transporter AL541_22915 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AL541_22920 ENOG4107YZP Rhodanese domain protein AL541_22925 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AL541_22930 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AL541_22935 ENOG4105D7W serine acetyltransferase AL541_22940 ENOG41063SB peptidase AL541_22950 ENOG41062JF Transcriptional regulator AL541_22960 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AL541_22970 ENOG4105E33 succinate dehydrogenase AL541_22975 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL541_22980 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL541_22990 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AL541_22995 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AL541_23000 ENOG4105KT7 mgtC SapB transporter AL541_23010 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL541_23015 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL541_23020 ENOG4107QI1 Mate efflux family protein AL541_23025 ENOG4105CTQ phosphohexokinase AL541_23030 ENOG41076HS cation diffusion facilitator family transporter AL541_23035 ENOG4108SPG Periplasmic Protein AL541_23040 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL541_23045 ENOG4105E0F Histidine kinase AL541_23055 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AL541_23060 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 AL541_23065 ENOG4108IJ0 Aspartate ammonia-lyase AL541_23070 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL541_23075 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL541_23085 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AL541_23095 ENOG4107QN1 sodium solute AL541_23110 ENOG4105C9Q fumarate hydratase class II AL541_23115 ENOG4105BZU Histidine kinase AL541_23120 ENOG4105D8G Major Facilitator superfamily AL541_23135 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL541_23140 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AL541_23145 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AL541_23150 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AL541_23160 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AL541_23165 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL541_23170 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AL541_23180 ENOG4105C5H ABC transporter AL541_23235 ENOG4105CXN decarboxylase AL541_23240 ENOG4105D5Q Arginine ornithine antiporter AL541_23250 ENOG4108M3R transcriptional activator CadC AL541_23255 ENOG4105W1Y Transcriptional regulator AL541_23265 ENOG4105DC1 bifunctional purine biosynthesis protein purh AL541_23270 ENOG4105C12 Phosphoribosylglycinamide synthetase AL541_23290 ENOG4105R2J Conserved Protein AL541_23295 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AL541_23300 ENOG4108RG0 uracil-dna glycosylase AL541_23305 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AL541_23310 ENOG4105E09 nadh pyrophosphatase AL541_23315 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor AL541_23320 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL541_23325 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL541_23330 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AL541_23335 ENOG4108VZM 50s ribosomal protein L10 AL541_23340 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AL541_23345 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AL541_23350 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AL541_23355 ENOG4105PM1 preprotein translocase subunit SecE AL541_23365 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL541_23395 ENOG4105CS9 pantothenic acid kinase AL541_23400 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AL541_23405 ENOG4105D4A Cell wall formation (By similarity) AL541_23415 ENOG4105JIM Phosphatidylserine synthase AL541_23480 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AL541_23490 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AL541_23495 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AL541_23510 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AL541_23515 ENOG4107R73 Mate efflux family protein AL541_23530 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AL541_23540 ENOG4105E55 glycerol-3-phosphate acyltransferase AL541_23545 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AL541_23550 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AL541_23555 ENOG4105X6C Flagellar basal body-associated protein FliL AL541_23560 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AL541_23565 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL541_23575 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL541_23580 ENOG4105CRP Part of the ABC transporter FtsEX involved in AL541_23585 ENOG4105CAK Cell division ATP-binding protein ftsE AL541_23590 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AL541_23595 ENOG4106H78 methyltransferase AL541_23605 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AL541_23650 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL541_23655 ENOG41082YX Transcriptional regulator, arsr family AL541_23660 ENOG4105D58 Diguanylate phosphodiesterase AL541_23665 ENOG410829K Lysine exporter protein (Lyse ygga) AL541_23670 ENOG4108EUD Lysophospholipase AL541_23675 ENOG4105DQF Hydrolase AL541_23690 ENOG4106IUH DTW domain containing protein AL541_23695 ENOG4105BZU Histidine kinase AL541_23700 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AL541_23705 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL541_23715 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AL541_23720 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL541_23730 ENOG4105XQ6 frataxin-like protein AL541_23735 ENOG4107T0K Adenylate cyclase AL541_23740 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AL541_23745 ENOG41076E6 Uroporphyrinogen-III Synthase AL541_23750 ENOG4105ECF c-methyltransferase AL541_23755 ENOG410601J HemY protein AL541_23795 ENOG4107QK7 reductase AL541_23800 ENOG4108ZIT Ferredoxin, 2FE-2S AL541_23805 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AL541_23815 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AL541_23820 ENOG4105K63 Thioredoxin AL541_23825 ENOG4105C1J atp-dependent rna helicase AL541_23830 ENOG4105C9X ppx gppa phosphatase AL541_23840 ENOG4105EX9 Membrane AL541_23855 ENOG4105C9U ATP-dependent DNA helicase RecQ AL541_23860 ENOG4105FR1 rard protein AL541_23875 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL541_23885 ENOG4105C4R Atp-dependent dna helicase AL541_23895 ENOG4105E18 UPF0276 protein AL541_23925 ENOG4105DC7 peptidase M24 AL541_23925 ENOG4105DC7 peptidase M24 AL541_23930 ENOG4105D41 biosynthesis protein thiH AL541_23935 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AL541_23945 ENOG4105D06 uba thif-type nad fad binding protein AL541_23955 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AL541_23960 ENOG4105WMR Protein CrcB homolog AL541_23965 ENOG4105E3B Multicopper oxidase AL541_24010 ENOG4108Z0R Transferase AL541_24015 ENOG4105SG3 Protein of unknown function (DUF1488) AL541_24020 ENOG4105E2X shikimate dehydrogenase AL541_24025 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AL541_24030 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL541_24035 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AL541_24040 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AL541_24045 ENOG4108WI1 Dna topoisomerase AL541_24055 ENOG4108RPN Protein smg homolog AL541_24060 ENOG4105C79 DNA protecting protein DprA AL541_24070 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL541_24075 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AL541_24080 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL541_24085 ENOG4105C1A potassium transporter peripheral membrane AL541_24090 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL541_24100 ENOG4108UT2 hemolysin iii AL541_24105 ENOG4108N23 SpoOM-related protein AL541_24115 ENOG4105PC1 Conserved Protein AL541_24125 ENOG4105E27 serine threonine protein kinase AL541_24130 ENOG4108Z33 Thiol disulfide Interchange Protein AL541_24135 ENOG4106HNH Acyl-transferase AL541_24145 ENOG4105C0P Mg chelatase subunit ChlI AL541_24155 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AL541_24160 ENOG4105CM2 brancheD-chain amino acid aminotransferase AL541_24165 ENOG4105C01 Dihydroxy-acid dehydratase AL541_24170 ENOG4105C7B Threonine dehydratase AL541_24175 ENOG4105F52 Transcriptional regulator AL541_24180 ENOG4105CZQ inner membrane transport protein YdhC AL541_24190 ENOG4105EAD ABC transporter AL541_24195 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AL541_24200 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AL541_24205 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AL541_24210 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AL541_24215 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AL541_24220 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL541_24230 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL541_24235 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AL541_24240 ENOG410684E atp synthase AL541_24245 ENOG4105FA0 parb-like partition protein AL541_24250 ENOG4107QJE Chromosome Partitioning Protein AL541_24255 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AL541_24260 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AL541_24265 ENOG4105QTB Flavodoxin AL541_24270 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AL541_24275 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AL541_24280 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AL541_24285 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AL541_24295 ENOG4105CDA abc transporter atp-binding protein AL541_24300 ENOG4105E5Q amino acid AbC transporter AL541_24305 ENOG4105EAB amino acid AbC transporter AL541_24315 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL541_24320 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AL541_24325 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AL541_24330 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL541_24350 ENOG4108ZNX Heat shock protein AL541_24355 ENOG4105JKW Valine--pyruvate aminotransferase AL541_24360 ENOG4107T9C Alpha amylase catalytic region AL541_24365 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AL541_24370 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AL541_24385 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AL541_24400 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AL541_24405 ENOG4105CHU acetyl-coa acetyltransferase AL541_24410 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL541_24415 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AL541_24420 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL541_24425 ENOG4108RR8 protoporphyrinogen oxidase AL541_24465 ENOG4105EMY transcriptional regulator AL541_24470 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AL541_24475 ENOG4105W0Z cytoplasmic protein AL541_24480 ENOG4105BZS acriflavin resistance protein AL541_24485 ENOG410624X efflux transporter, rnd family, mfp subunit AL541_24490 ENOG41067SE Tetr family transcriptional regulator AL541_24495 ENOG4105C4R Atp-dependent dna helicase AL541_24500 ENOG4105MPD Cytochrome AL541_24540 ENOG4108JQ6 ABC transporter AL541_24545 ENOG4107QSI ABC, transporter AL541_24550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL541_24555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL541_24595 ENOG4105DIQ Transcriptional regulator AL541_24600 ENOG41064T2 transcriptional regulator, lysR family AL541_24605 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AL541_24610 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) AL541_24615 ENOG4105C01 Dihydroxy-acid dehydratase AL541_24620 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AL541_24625 ENOG4105C6Z Gluconate AL541_24630 ENOG4108UHU Aldolase AL541_24635 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AL541_24640 ENOG4107RSM transcriptional regulator AL541_24645 ENOG4105DC8 reductase AL541_24650 ENOG4105D6S protein involved in catabolism of external DNA AL541_24655 ENOG4105DGW oligopeptidase A AL541_24660 ENOG4108VVK transcriptional Regulator, AsnC AL541_24665 ENOG4105BZU Histidine kinase AL541_24670 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AL541_24680 ENOG4105EMK carboxylate amino acid amine transporter AL541_24685 ENOG4108M6U Universal stress protein A AL541_24690 ENOG41090A1 ferritin AL541_24695 ENOG4108V6B universal stress protein B AL541_24700 ENOG4105CBX hi0933 family AL541_24705 ENOG4108JUA Transcriptional regulator AL541_24730 ENOG4107TE5 Lipid kinase AL541_24760 ENOG4105DSF transport protein AL541_24765 ENOG4105BZU Histidine kinase AL541_24775 ENOG4105CGY Dna recombination protein AL541_24780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AL541_24785 ENOG4105JC1 sterol-binding domain protein AL541_24790 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL541_24795 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AL541_24800 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AL541_24805 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AL541_24815 ENOG4105F8V Hydrolase, tatD family AL541_24825 ENOG4105D52 delta-aminolevulinic acid dehydratase AL541_24830 ENOG4105KD7 acetyltransferase AL541_24840 ENOG4105C2M dna polymerase I AL541_24845 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AL541_24850 ENOG4106RE7 Cytochrome AL541_24865 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AL541_24870 ENOG4105XCT Protein of unknown function (DUF2489) AL541_24875 ENOG4105D4P Coproporphyrinogen iii oxidase AL541_24880 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL541_24885 ENOG4105BZU Histidine kinase AL541_24890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL541_24895 ENOG4105CUX Signal transduction histidine kinase AL541_24905 ENOG4105C5F glutamine synthetase AL541_24915 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL541_24925 ENOG4107S2Z UPF0761 membrane protein AL541_24930 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AL541_24935 ENOG4105SUU thioesterase domain AL541_24945 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AL541_24950 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AL541_24955 ENOG4105VEJ Heat shock protein AL541_24960 ENOG4108XKW General secretion pathway protein C AL541_24970 ENOG4107QHF type ii secretion system protein e AL541_24975 ENOG4105D7Q type ii secretion system AL541_24980 ENOG4108VAU general secretion pathway protein G AL541_24985 ENOG4105VWV general secretion pathway protein h AL541_24990 ENOG4105X5Z General secretion pathway protein I AL541_24995 ENOG4108WWZ General secretion pathway protein J AL541_25000 ENOG4108RTD type II secretion system protein K AL541_25005 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) AL541_25010 ENOG4105U1E general secretion pathway protein M AL541_25015 ENOG4105PIC general secretion pathway protein N AL541_25025 ENOG4107RK2 ADP-ribose diphosphatase NudE AL541_25030 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AL541_25035 ENOG4105MJ2 Competence protein AL541_25040 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL541_25050 ENOG4105BZM domain protein AL541_25060 ENOG4108RRZ Transcription elongation factor GreB AL541_25070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL541_25075 ENOG4105E0F Histidine kinase AL541_25080 ENOG4105C2W permease AL541_25085 ENOG4105CB5 ATP-dependent DNA helicase recG AL541_25090 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AL541_25095 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL541_25100 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AL541_25105 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AL541_25125 ENOG4109015 Biopolymer transport protein exbD tolR AL541_25155 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AL541_25160 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AL541_25165 ENOG4107QRA Extracellular solute-binding protein, family 5 AL541_25175 ENOG4108JQ7 (ABC) transporter AL541_25185 ENOG4105DSJ YicC domain protein AL541_25195 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AL541_25200 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AL541_25205 ENOG4105D1S lipid A biosynthesis AL541_25210 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AL541_25215 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AL541_25225 ENOG4105C8Q Methyl-accepting chemotaxis AL541_25230 ENOG4105W5Q DNA repair protein (RadC AL541_25235 ENOG4105KDC 50s ribosomal protein l28 AL541_25250 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AL541_25255 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AL541_25260 ENOG4108JMC lipopolysaccharide core biosynthesis protein AL541_25270 ENOG4106WTF Glycosyl transferase, family 2 AL541_25275 ENOG4105DKP glycosyl transferase, family 9 AL541_25280 ENOG41080IJ Diacylglycerol kinase AL541_25285 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) AL541_25290 ENOG4105C1B dTDP-glucose 4-6-dehydratase AL541_25295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AL541_25315 ENOG4108P1X synthase AL541_25325 ENOG4105CHR reductase AL541_25330 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AL541_25345 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AL541_25350 ENOG4105XA0 heptosyltransferase ii AL541_25360 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AL541_25365 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AL541_25370 ENOG4105E3R (LipO)protein AL541_25440 ENOG4105C0K Gdp-mannose 4,6-dehydratase AL541_25445 ENOG4105C30 Nad-dependent epimerase dehydratase AL541_25450 ENOG4105FGF GDP-mannose mannosyl hydrolase AL541_25455 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AL541_25460 ENOG4106ECQ phosphomannomutase AL541_25465 ENOG4105EIP mannose-6-phosphate isomerase AL541_25480 ENOG4105D3Q Sugar transferase AL541_25495 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AL541_25500 ENOG4105CY0 Metallo-Beta-Lactamase AL541_25505 ENOG4105CP7 Triose-phosphate isomerase