locus-tag	class	description
HLBS07_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLBS07_00020	COG0592	DNA-directed DNA polymerase activity
HLBS07_00040	COG0187	DNA topoisomerase II activity
HLBS07_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
HLBS07_00080	COG3977	Valine--pyruvate aminotransferase
HLBS07_00090	COG0366	Alpha amylase catalytic
HLBS07_00120	COG2119	membrane
HLBS07_00140	COG0425	Belongs to the sulfur carrier protein TusA family
HLBS07_00170	COG0604	alcohol dehydrogenase
HLBS07_00180	COG0183	Belongs to the thiolase family
HLBS07_00200	COG1739	Uncharacterized protein family UPF0029
HLBS07_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLBS07_00230	COG0583	DNA-binding transcription factor activity
HLBS07_00240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLBS07_00250	COG2960	long-chain fatty acid transporting porin activity
HLBS07_00260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLBS07_00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_00330	COG4166	transmembrane transport
HLBS07_00340	COG0601	transmembrane transport
HLBS07_00350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLBS07_00430	COG1609	Transcriptional regulator
HLBS07_00440	COG0583	DNA-binding transcription factor activity
HLBS07_00470	COG0129	dihydroxy-acid dehydratase activity
HLBS07_00480	COG3265	gluconokinase activity
HLBS07_00490	COG2610	gluconate transmembrane transporter activity
HLBS07_00500	COG0800	Aldolase
HLBS07_00510	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HLBS07_00520	COG0583	DNA-binding transcription factor activity
HLBS07_00530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLBS07_00540	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HLBS07_00560	COG1522	sequence-specific DNA binding
HLBS07_00570	COG5002	protein histidine kinase activity
HLBS07_00570	COG5001	Diguanylate cyclase
HLBS07_00580	COG0742	ribosomal rna small subunit methyltransferase
HLBS07_00610	COG0589	response to stress
HLBS07_00620	COG1528	Iron-storage protein
HLBS07_00640	COG2081	HI0933 family
HLBS07_00710	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLBS07_00720	COG0732	type I restriction modification DNA specificity domain
HLBS07_00730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLBS07_00800	COG1597	lipid kinase activity
HLBS07_00860	COG0628	permease
HLBS07_00890	COG1322	Protein conserved in bacteria
HLBS07_00900	COG2226	methyltransferase
HLBS07_00910	COG2226	methyltransferase
HLBS07_00920	COG3165	ubiquinone biosynthetic process from chorismate
HLBS07_00930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLBS07_00950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLBS07_00960	COG0805	protein transport
HLBS07_00970	COG0084	hydrolase, TatD family'
HLBS07_00990	COG0456	acetyltransferase
HLBS07_01000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLBS07_01000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLBS07_01010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HLBS07_01070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLBS07_01090	COG2204	response regulator
HLBS07_01100	COG3852	Histidine kinase
HLBS07_01120	COG0174	glutamine synthetase
HLBS07_01130	COG1217	gtp-binding protein TYPA
HLBS07_01140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLBS07_01160	COG1295	ribonuclease BN
HLBS07_01170	COG1490	D-aminoacyl-tRNA deacylase activity
HLBS07_01180	COG0456	acetyltransferase
HLBS07_01200	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HLBS07_01210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLBS07_01220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLBS07_01230	COG3031	protein transport across the cell outer membrane
HLBS07_01250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLBS07_01260	COG1459	type II secretion system
HLBS07_01270	COG2165	general secretion pathway protein
HLBS07_01280	COG2165	general secretion pathway protein
HLBS07_01290	COG2165	general secretion pathway protein
HLBS07_01300	COG4795	General secretion pathway protein
HLBS07_01310	COG3156	type II secretion system protein K
HLBS07_01320	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HLBS07_01330	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HLBS07_01350	COG1218	3'(2'),5'-bisphosphate nucleotidase
HLBS07_01360	COG0494	nUDIX hydrolase
HLBS07_01380	COG1040	competence protein
HLBS07_01410	COG2183	response to ionizing radiation
HLBS07_01440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLBS07_01490	COG2233	PERMEase
HLBS07_01500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLBS07_01510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLBS07_01520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLBS07_01530	COG1758	RNA polymerase activity
HLBS07_01540	COG0194	GDP metabolic process
HLBS07_01570	COG0848	biopolymer transport protein
HLBS07_01580	COG0811	peptide transport
HLBS07_01630	COG4174	ABC transporter (Permease)
HLBS07_01640	COG4239	(ABC) transporter, permease
HLBS07_01650	COG0747	negative chemotaxis
HLBS07_01660	COG0444	Belongs to the ABC transporter superfamily
HLBS07_01670	COG4608	Belongs to the ABC transporter superfamily
HLBS07_01690	COG1561	YicC-like family, N-terminal region
HLBS07_01700	COG1561	YicC-like family, N-terminal region
HLBS07_01710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLBS07_01720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLBS07_01730	COG1560	Kdo2-lipid A biosynthetic process
HLBS07_01740	COG1309	transcriptional regulator
HLBS07_01750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLBS07_01770	COG2003	Belongs to the UPF0758 family
HLBS07_01820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLBS07_01860	COG0463	Glycosyl transferase, family 2
HLBS07_01870	COG0859	PFAM glycosyl transferase family 9
HLBS07_01880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLBS07_01890	COG3642	lipopolysaccharide core region biosynthetic process
HLBS07_01950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLBS07_01970	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_01980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLBS07_02010	COG1519	Transferase
HLBS07_02020	COG0859	PFAM glycosyl transferase family 9
HLBS07_02040	COG1560	Kdo2-lipid A biosynthetic process
HLBS07_02060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLBS07_02130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLBS07_02200	COG1216	Glycosyl transferase, family 2
HLBS07_02210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLBS07_02260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLBS07_02270	COG0149	triose-phosphate isomerase activity
HLBS07_02320	COG1494	fructose-1,6-bisphosphatase
HLBS07_02330	COG1494	fructose-1,6-bisphosphatase
HLBS07_02350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLBS07_02360	COG1575	Belongs to the MenA family. Type 1 subfamily
HLBS07_02380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HLBS07_02390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HLBS07_02410	COG1609	Transcriptional regulator
HLBS07_02420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLBS07_02430	COG0254	rRNA binding
HLBS07_02450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLBS07_02460	COG0088	Forms part of the polypeptide exit tunnel
HLBS07_02480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLBS07_02490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLBS07_02500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLBS07_02510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLBS07_02530	COG0255	Belongs to the universal ribosomal protein uL29 family
HLBS07_02540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HLBS07_02560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HLBS07_02570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLBS07_02590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLBS07_02600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLBS07_02630	COG1841	ribosomal large subunit assembly
HLBS07_02640	COG0200	Binds to the 23S rRNA
HLBS07_02650	COG0201	protein transport
HLBS07_02660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLBS07_02670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HLBS07_02690	COG0202	RNA polymerase activity
HLBS07_02700	COG0203	ribosomal protein L17
HLBS07_02730	COG0545	Peptidyl-prolyl cis-trans isomerase
HLBS07_02750	COG2153	protein acetylation
HLBS07_02760	COG0513	Belongs to the DEAD box helicase family
HLBS07_02790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLBS07_02790	COG1648	precorrin-2 dehydrogenase activity
HLBS07_02800	COG0175	sulfate reduction
HLBS07_02810	COG2895	sulfate adenylyltransferase (ATP) activity
HLBS07_02820	COG0471	metal ion transport
HLBS07_02820	COG3273	potassium ion transport
HLBS07_02830	COG0529	Catalyzes the synthesis of activated sulfate
HLBS07_02870	COG4181	ATPase activity
HLBS07_02890	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HLBS07_02910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLBS07_02920	COG0729	surface antigen
HLBS07_02930	COG2911	Protein conserved in bacteria
HLBS07_02940	COG2105	PFAM AIG2 family protein
HLBS07_02960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLBS07_02970	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HLBS07_02980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLBS07_02990	COG0163	prenyltransferase activity
HLBS07_03000	COG4143	(ABC) transporter
HLBS07_03010	COG1178	ABC-type Fe3 transport system permease component
HLBS07_03020	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HLBS07_03030	COG0583	DNA-binding transcription factor activity
HLBS07_03040	COG1902	pentaerythritol trinitrate reductase activity
HLBS07_03070	COG2358	TRAP transporter, solute receptor (TAXI family
HLBS07_03110	COG0142	geranyltranstransferase activity
HLBS07_03120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLBS07_03140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLBS07_03150	COG2966	Psort location CytoplasmicMembrane, score
HLBS07_03170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLBS07_03180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLBS07_03190	COG2967	ApaG domain
HLBS07_03200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLBS07_03210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLBS07_03220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLBS07_03230	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HLBS07_03240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HLBS07_03280	COG0473	3-isopropylmalate dehydrogenase activity
HLBS07_03290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLBS07_03330	COG0583	DNA-binding transcription factor activity
HLBS07_03340	COG1022	Amp-dependent synthetase and ligase
HLBS07_03350	COG0028	Belongs to the TPP enzyme family
HLBS07_03360	COG0440	acetolactate synthase activity
HLBS07_03390	COG0469	pyruvate kinase activity
HLBS07_03400	COG1349	DNA-binding transcription factor activity
HLBS07_03410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLBS07_03430	COG2376	Dihydroxyacetone kinase
HLBS07_03440	COG1461	Dihydroxyacetone kinase
HLBS07_03460	COG3284	Transcriptional regulator
HLBS07_03480	COG3722	fumarate hydratase activity
HLBS07_03500	COG2213	PTS system mannitol-specific
HLBS07_03500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLBS07_03550	COG0582	viral genome integration into host DNA
HLBS07_03700	COG0358	DNA primase activity
HLBS07_03710	COG1610	YqeY-like protein
HLBS07_03720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLBS07_03730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HLBS07_03740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLBS07_03750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLBS07_03760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLBS07_03770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLBS07_03780	COG1968	undecaprenyl-diphosphatase activity
HLBS07_03800	COG3267	Type II secretory pathway component ExeA
HLBS07_03800	COG3409	Peptidoglycan-binding domain 1 protein
HLBS07_03820	COG0405	Gamma-glutamyltransferase
HLBS07_03830	COG4991	sh3 domain protein
HLBS07_03840	COG0306	phosphate transporter
HLBS07_03850	COG1392	Phosphate transport regulator
HLBS07_03860	COG3025	triphosphatase activity
HLBS07_03890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLBS07_03900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLBS07_03900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLBS07_03910	COG1538	Outer membrane efflux protein
HLBS07_03920	COG0494	nUDIX hydrolase
HLBS07_03930	COG3151	Protein conserved in bacteria
HLBS07_03950	COG3150	esterase
HLBS07_03970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLBS07_03980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLBS07_04000	COG3105	Protein conserved in bacteria
HLBS07_04010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLBS07_04030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLBS07_04040	COG0723	plastoquinol--plastocyanin reductase activity
HLBS07_04050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLBS07_04060	COG2857	Cytochrome c1
HLBS07_04070	COG0625	glutathione transferase activity
HLBS07_04080	COG2969	positive regulation of protein catabolic process
HLBS07_04090	COG2823	Periplasmic or secreted lipoprotein
HLBS07_04100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HLBS07_04130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLBS07_04150	COG3116	cell division
HLBS07_04160	COG0768	penicillin binding
HLBS07_04170	COG0768	penicillin binding
HLBS07_04180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLBS07_04190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLBS07_04200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLBS07_04210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLBS07_04220	COG0772	Belongs to the SEDS family
HLBS07_04250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLBS07_04260	COG0849	cell division
HLBS07_04270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLBS07_04280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HLBS07_04300	COG0653	protein targeting
HLBS07_04310	COG0494	nUDIX hydrolase
HLBS07_04330	COG0505	Belongs to the CarA family
HLBS07_04340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLBS07_04370	COG0730	response to heat
HLBS07_04380	COG0583	DNA-binding transcription factor activity
HLBS07_04390	COG2860	membrane
HLBS07_04420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLBS07_04440	COG0493	'glutamate synthase
HLBS07_04450	COG0067	glutamate synthase
HLBS07_04450	COG0069	glutamate synthase activity
HLBS07_04450	COG0070	glutamate synthase
HLBS07_04470	COG0067	glutamate synthase
HLBS07_04470	COG0069	glutamate synthase activity
HLBS07_04470	COG0070	glutamate synthase
HLBS07_04480	COG1242	4 iron, 4 sulfur cluster binding
HLBS07_04490	COG3706	GGDEF domain
HLBS07_04490	COG2203	Gaf domain
HLBS07_04490	COG5001	Diguanylate cyclase
HLBS07_04490	COG4251	negative regulation of phosphorylation
HLBS07_04500	COG0784	Response regulator, receiver
HLBS07_04500	COG2198	Histidine kinase
HLBS07_04500	COG5002	protein histidine kinase activity
HLBS07_04520	COG0745	RESPONSE REGULATOR receiver
HLBS07_04530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLBS07_04560	COG0083	homoserine kinase activity
HLBS07_04570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLBS07_04590	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HLBS07_04600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HLBS07_04610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLBS07_04640	COG1115	amino acid carrier protein
HLBS07_04650	COG3022	response to hydroperoxide
HLBS07_04660	COG0513	Belongs to the DEAD box helicase family
HLBS07_04670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLBS07_04690	COG0716	FMN binding
HLBS07_04700	COG4974	Belongs to the 'phage' integrase family
HLBS07_04710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLBS07_04720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLBS07_04730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HLBS07_04750	COG2204	response regulator
HLBS07_04770	COG0667	Aldo Keto reductase
HLBS07_04820	COG0730	response to heat
HLBS07_04830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLBS07_04840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLBS07_04940	COG1278	Cold shock
HLBS07_04980	COG1278	Cold shock
HLBS07_05040	COG3550	peptidyl-serine autophosphorylation
HLBS07_05110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLBS07_05120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLBS07_05140	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLBS07_05150	COG0583	DNA-binding transcription factor activity
HLBS07_05160	COG0640	Transcriptional regulator
HLBS07_05170	COG0268	Binds directly to 16S ribosomal RNA
HLBS07_05180	COG0728	peptidoglycan biosynthetic process
HLBS07_05190	COG0728	peptidoglycan biosynthetic process
HLBS07_05200	COG0728	peptidoglycan biosynthetic process
HLBS07_05210	COG0196	riboflavin kinase activity
HLBS07_05240	COG1047	Peptidyl-prolyl cis-trans
HLBS07_05250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLBS07_05270	COG3279	Response regulator of the LytR AlgR family
HLBS07_05280	COG3275	phosphorelay sensor kinase activity
HLBS07_05300	COG1966	Carbon starvation protein
HLBS07_05340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HLBS07_05350	COG1472	Belongs to the glycosyl hydrolase 3 family
HLBS07_05360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLBS07_05370	COG1605	Chorismate mutase
HLBS07_05370	COG0287	Prephenate dehydrogenase
HLBS07_05380	COG0739	heme binding
HLBS07_05400	COG0488	(ABC) transporter
HLBS07_05420	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HLBS07_05430	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLBS07_05440	COG1605	Chorismate mutase
HLBS07_05440	COG0077	Prephenate dehydratase
HLBS07_05450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLBS07_05470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLBS07_05480	COG0564	pseudouridine synthase activity
HLBS07_05500	COG0542	response to heat
HLBS07_05540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLBS07_05550	COG0826	peptidase U32
HLBS07_05560	COG2974	May be involved in recombination
HLBS07_05570	COG0745	RESPONSE REGULATOR receiver
HLBS07_05580	COG5002	protein histidine kinase activity
HLBS07_05600	COG0248	Ppx GppA phosphatase
HLBS07_05610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLBS07_05620	COG0573	inorganic phosphate transmembrane transporter activity
HLBS07_05630	COG0581	inorganic phosphate transmembrane transporter activity
HLBS07_05640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLBS07_05650	COG0704	Plays a role in the regulation of phosphate uptake
HLBS07_05670	COG3142	Participates in the control of copper homeostasis
HLBS07_05690	COG0450	alkyl hydroperoxide reductase
HLBS07_05700	COG0583	DNA-binding transcription factor activity
HLBS07_05710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLBS07_05730	COG0517	IMP dehydrogenase activity
HLBS07_05750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLBS07_05770	COG1862	Preprotein translocase
HLBS07_05780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLBS07_05790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLBS07_05820	COG0483	inositol monophosphate 1-phosphatase activity
HLBS07_05830	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HLBS07_05850	COG1104	cysteine desulfurase activity
HLBS07_05860	COG0822	iron-sulfur transferase activity
HLBS07_05890	COG0443	Heat shock 70 kDa protein
HLBS07_05900	COG0633	Ferredoxin
HLBS07_05910	COG2975	iron-sulfur cluster assembly
HLBS07_05930	COG0105	UTP biosynthetic process
HLBS07_05960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLBS07_05970	COG0124	histidyl-tRNA synthetase
HLBS07_05980	COG2976	Protein conserved in bacteria
HLBS07_05990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLBS07_06000	COG1160	GTP binding
HLBS07_06040	COG0517	IMP dehydrogenase activity
HLBS07_06040	COG0516	GMP reductase activity
HLBS07_06060	COG1757	Na H antiporter
HLBS07_06080	COG1584	GPR1 FUN34 yaaH family protein
HLBS07_06090	COG1115	amino acid carrier protein
HLBS07_06120	COG2873	o-acetylhomoserine
HLBS07_06130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLBS07_06170	COG3153	acetyltransferase
HLBS07_06170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLBS07_06180	COG0583	DNA-binding transcription factor activity
HLBS07_06220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLBS07_06230	COG2867	negative regulation of translational initiation
HLBS07_06240	COG2914	Belongs to the UPF0125 (RnfH) family
HLBS07_06250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLBS07_06270	COG0497	DNA recombination
HLBS07_06290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLBS07_06300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLBS07_06310	COG1301	dicarboxylic acid transport
HLBS07_06320	COG0443	Heat shock 70 kDa protein
HLBS07_06340	COG0484	heat shock protein binding
HLBS07_06400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HLBS07_06430	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HLBS07_06440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLBS07_06440	COG0047	phosphoribosylformylglycinamidine synthase activity
HLBS07_06500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLBS07_06520	COG2252	PERMEase
HLBS07_06530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HLBS07_06540	COG1073	alpha beta
HLBS07_06560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HLBS07_06570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HLBS07_06580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLBS07_06590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLBS07_06590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLBS07_06620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HLBS07_06640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HLBS07_06650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLBS07_06660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLBS07_06670	COG0142	geranyltranstransferase activity
HLBS07_06680	COG1722	exodeoxyribonuclease VII activity
HLBS07_06690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLBS07_06710	COG0301	tRNA thio-modification
HLBS07_06710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLBS07_06720	COG0583	DNA-binding transcription factor activity
HLBS07_06740	COG2363	Small membrane protein
HLBS07_06760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLBS07_06770	COG1611	Belongs to the LOG family
HLBS07_06800	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLBS07_06800	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLBS07_06820	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HLBS07_06830	COG1464	Belongs to the NlpA lipoprotein family
HLBS07_06840	COG2011	ABC-type metal ion transport system permease component
HLBS07_06850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLBS07_06870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLBS07_06890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_06890	COG1263	PTS System
HLBS07_06900	COG0366	Alpha amylase catalytic
HLBS07_06930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLBS07_06940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLBS07_06950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLBS07_06960	COG0321	lipoyl(octanoyl) transferase activity
HLBS07_06980	COG1686	Belongs to the peptidase S11 family
HLBS07_06990	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLBS07_07000	COG0772	Belongs to the SEDS family
HLBS07_07010	COG0768	penicillin binding
HLBS07_07020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HLBS07_07030	COG0799	negative regulation of ribosome biogenesis
HLBS07_07040	COG1466	dna polymerase III delta subunit
HLBS07_07050	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HLBS07_07060	COG0495	leucyl-tRNA aminoacylation
HLBS07_07070	COG2888	peptidyl-tyrosine sulfation
HLBS07_07080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HLBS07_07090	COG4535	Mg2 and Co2 transporter CorC
HLBS07_07100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLBS07_07110	COG1702	phosphate starvation-inducible protein PhoH
HLBS07_07120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLBS07_07130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLBS07_07140	COG0012	GTP binding
HLBS07_07150	COG0193	aminoacyl-tRNA hydrolase activity
HLBS07_07160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLBS07_07170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLBS07_07180	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HLBS07_07190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HLBS07_07210	COG2890	protein-(glutamine-N5) methyltransferase activity
HLBS07_07220	COG3094	Invasion gene expression up-regulator, SirB
HLBS07_07230	COG2912	Transglutaminase-like superfamily
HLBS07_07240	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HLBS07_07250	COG0737	Belongs to the 5'-nucleotidase family
HLBS07_07260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLBS07_07270	COG1187	pseudouridine synthase activity
HLBS07_07280	COG2840	Smr protein MutS2
HLBS07_07340	COG2608	mercury ion transmembrane transporter activity
HLBS07_07340	COG2217	Heavy metal translocating P-type atpase
HLBS07_07360	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HLBS07_07460	COG0784	Response regulator, receiver
HLBS07_07460	COG0835	chemotaxis
HLBS07_07470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLBS07_07480	COG1815	bacterial-type flagellum-dependent cell motility
HLBS07_07490	COG1558	bacterial-type flagellum-dependent cell motility
HLBS07_07510	COG1749	Flagellar hook protein flgE
HLBS07_07520	COG4787	bacterial-type flagellum-dependent cell motility
HLBS07_07540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HLBS07_07550	COG1706	bacterial-type flagellum-dependent cell motility
HLBS07_07560	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLBS07_07560	COG3951	Flagellar rod assembly protein muramidase FlgJ
HLBS07_07580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_07590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_07600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_07610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_07620	COG2190	(PTS) system
HLBS07_07630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLBS07_07640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLBS07_07650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLBS07_07660	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HLBS07_07670	COG3115	cell septum assembly
HLBS07_07680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLBS07_07730	COG0330	HflC and HflK could
HLBS07_07740	COG3118	belongs to the thioredoxin family
HLBS07_07750	COG0300	oxidoreductase activity
HLBS07_07760	COG1090	epimerase
HLBS07_07810	COG0622	Phosphoesterase
HLBS07_07850	COG3710	Transcriptional regulator
HLBS07_07860	COG0326	Molecular chaperone. Has ATPase activity
HLBS07_07880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HLBS07_07890	COG3104	oligopeptide transport
HLBS07_07900	COG0250	Participates in transcription elongation, termination and antitermination
HLBS07_07910	COG0367	asparagine synthase
HLBS07_07920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLBS07_07920	COG4651	solute:proton antiporter activity
HLBS07_07930	COG1846	Transcriptional regulator
HLBS07_07930	COG1940	carbohydrate kinase activity
HLBS07_07940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLBS07_07950	COG1263	PTS System
HLBS07_07950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_07950	COG2190	(PTS) system
HLBS07_07960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLBS07_07970	COG0735	belongs to the Fur family
HLBS07_07990	COG0716	FMN binding
HLBS07_08010	COG0596	Alpha beta hydrolase
HLBS07_08020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HLBS07_08030	COG0033	Phosphoglucomutase
HLBS07_08050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLBS07_08080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HLBS07_08090	COG1053	succinate dehydrogenase
HLBS07_08100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLBS07_08110	COG0567	Dehydrogenase, E1 component
HLBS07_08120	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLBS07_08130	COG0045	succinate-CoA ligase (ADP-forming) activity
HLBS07_08150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLBS07_08160	COG1121	(ABC) transporter
HLBS07_08170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HLBS07_08190	COG4977	sequence-specific DNA binding
HLBS07_08200	COG1918	ferrous iron import across plasma membrane
HLBS07_08250	COG0018	arginyl-trna synthetase
HLBS07_08260	COG3102	Protein conserved in bacteria
HLBS07_08270	COG0788	formyltetrahydrofolate deformylase activity
HLBS07_08290	COG1199	ATP-dependent helicase activity
HLBS07_08300	COG1214	PFAM Peptidase M22, glycoprotease
HLBS07_08320	COG3065	identical protein binding
HLBS07_08330	COG2267	carboxylic ester hydrolase activity
HLBS07_08340	COG0318	PFAM AMP-dependent synthetase and ligase
HLBS07_08350	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HLBS07_08360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HLBS07_08370	COG2894	cell division
HLBS07_08380	COG0850	regulation of cytokinetic process
HLBS07_08390	COG3100	YcgL domain-containing protein
HLBS07_08400	COG2951	lytic endotransglycosylase activity
HLBS07_08420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLBS07_08430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLBS07_08450	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_08470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLBS07_08520	COG2986	histidine ammonia-lyase
HLBS07_08530	COG1216	Glycosyl transferase, family 2
HLBS07_08540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLBS07_08570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLBS07_08580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLBS07_08650	COG0513	Belongs to the DEAD box helicase family
HLBS07_08660	COG0569	domain protein
HLBS07_08670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLBS07_08700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLBS07_08710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLBS07_08720	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLBS07_08730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLBS07_08780	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLBS07_08800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLBS07_08810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLBS07_08820	COG0776	regulation of translation
HLBS07_08830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLBS07_08840	COG1555	photosystem II stabilization
HLBS07_08870	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HLBS07_08890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HLBS07_08900	COG0436	Aminotransferase
HLBS07_08920	COG1169	isochorismate synthase
HLBS07_08930	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HLBS07_08950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLBS07_08990	COG2855	membrane
HLBS07_09000	COG0477	Major facilitator Superfamily
HLBS07_09030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_09040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLBS07_09070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLBS07_09080	COG1522	sequence-specific DNA binding
HLBS07_09110	COG1946	Acyl-CoA thioesterase
HLBS07_09120	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HLBS07_09350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_09410	COG4251	negative regulation of phosphorylation
HLBS07_09430	COG2203	Gaf domain
HLBS07_09430	COG2200	EAL domain
HLBS07_09430	COG2199	diguanylate cyclase activity
HLBS07_09440	COG2204	response regulator
HLBS07_09450	COG2204	response regulator
HLBS07_09540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLBS07_09550	COG0251	oxidation-reduction process
HLBS07_09560	COG0006	proline dipeptidase activity
HLBS07_09600	COG2964	Protein conserved in bacteria
HLBS07_09610	COG0006	proline dipeptidase activity
HLBS07_09630	COG1473	amidohydrolase
HLBS07_09670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLBS07_09680	COG0516	GMP reductase activity
HLBS07_09680	COG0517	IMP dehydrogenase activity
HLBS07_09730	COG0537	adenosine 5'-monophosphoramidase activity
HLBS07_09780	COG3150	esterase
HLBS07_09790	COG1252	NADH dehydrogenase
HLBS07_09820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLBS07_09840	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLBS07_09850	COG1136	(ABC) transporter
HLBS07_09860	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLBS07_09870	COG0658	competence protein
HLBS07_09870	COG2333	competence protein COMEC
HLBS07_09890	COG1132	(ABC) transporter
HLBS07_09930	COG2719	SpoVR family
HLBS07_09940	COG2718	Belongs to the UPF0229 family
HLBS07_09950	COG2766	serine protein kinase
HLBS07_09960	COG3013	Belongs to the UPF0304 family
HLBS07_09980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLBS07_10000	COG1882	Formate acetyltransferase
HLBS07_10080	COG0708	Exodeoxyribonuclease III
HLBS07_10100	COG3923	Primosomal replication protein n
HLBS07_10110	COG0730	response to heat
HLBS07_10120	COG1199	ATP-dependent helicase activity
HLBS07_10130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLBS07_10140	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HLBS07_10150	COG1187	pseudouridine synthase activity
HLBS07_10170	COG1278	Cold shock
HLBS07_10190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLBS07_10200	COG0542	response to heat
HLBS07_10210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLBS07_10220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HLBS07_10230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HLBS07_10270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLBS07_10280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLBS07_10290	COG0297	glycogen (starch) synthase activity
HLBS07_10330	COG3070	regulator of competence-specific genes
HLBS07_10340	COG1609	Transcriptional regulator
HLBS07_10350	COG3381	protein complex oligomerization
HLBS07_10360	COG0745	RESPONSE REGULATOR receiver
HLBS07_10370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HLBS07_10380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLBS07_10390	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HLBS07_10400	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HLBS07_10410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HLBS07_10450	COG4067	protein conserved in archaea
HLBS07_10450	COG0189	ligase activity
HLBS07_10480	COG1801	Protein of unknown function DUF72
HLBS07_10500	COG0217	transcriptional regulatory protein
HLBS07_10510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HLBS07_10520	COG0632	four-way junction helicase activity
HLBS07_10530	COG2255	four-way junction helicase activity
HLBS07_10540	COG1271	oxidase subunit
HLBS07_10550	COG1294	oxidase, subunit
HLBS07_10570	COG0824	Thioesterase
HLBS07_10580	COG0811	peptide transport
HLBS07_10610	COG0823	Involved in the tonB-independent uptake of proteins
HLBS07_10620	COG2885	chlorophyll binding
HLBS07_10630	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HLBS07_10640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HLBS07_10660	COG3766	membrane
HLBS07_10680	COG0754	glutathionylspermidine amidase activity
HLBS07_10700	COG5002	protein histidine kinase activity
HLBS07_10700	COG0784	Response regulator, receiver
HLBS07_10720	COG1294	oxidase, subunit
HLBS07_10770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_10780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLBS07_10830	COG3568	Endonuclease Exonuclease Phosphatase
HLBS07_10880	COG0583	DNA-binding transcription factor activity
HLBS07_10900	COG0686	Belongs to the AlaDH PNT family
HLBS07_10920	COG1674	ftsk spoiiie
HLBS07_10940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLBS07_10980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLBS07_11000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HLBS07_11030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HLBS07_11070	COG0300	oxidoreductase activity
HLBS07_11100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLBS07_11120	COG2268	Band 7 protein
HLBS07_11140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLBS07_11150	COG2915	High frequency lysogenization protein hflD homolog
HLBS07_11180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLBS07_11200	COG1757	Na H antiporter
HLBS07_11220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLBS07_11240	COG0131	Imidazoleglycerol-phosphate dehydratase
HLBS07_11240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLBS07_11250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLBS07_11260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLBS07_11280	COG0140	phosphoribosyl-ATP diphosphatase activity
HLBS07_11280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLBS07_11290	COG3012	SEC-C Motif Domain Protein
HLBS07_11300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HLBS07_11310	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLBS07_11320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLBS07_11330	COG0215	cysteine-tRNA ligase activity
HLBS07_11340	COG1435	thymidine kinase activity
HLBS07_11350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HLBS07_11400	COG2116	formate transmembrane transporter activity
HLBS07_11420	COG0390	transport system, permease component
HLBS07_11430	COG4459	periplasmic nitrate reductase
HLBS07_11440	COG3005	denitrification pathway
HLBS07_11450	COG0243	molybdopterin cofactor binding
HLBS07_11480	COG1227	inorganic diphosphatase activity
HLBS07_11500	COG4172	Belongs to the ABC transporter superfamily
HLBS07_11520	COG4171	peptide transport system, permease
HLBS07_11550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HLBS07_11560	COG1842	Phage shock protein A
HLBS07_11580	COG1983	PspC domain protein
HLBS07_11610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLBS07_11630	COG2818	Glycosylase
HLBS07_11640	COG5380	lipid catabolic process
HLBS07_11650	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HLBS07_11660	COG0626	cystathionine gamma-synthase activity
HLBS07_11680	COG0733	neurotransmitter:sodium symporter activity
HLBS07_11690	COG0564	pseudouridine synthase activity
HLBS07_11700	COG0564	pseudouridine synthase activity
HLBS07_11720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLBS07_11730	COG1151	hydroxylamine reductase activity
HLBS07_11740	COG3604	Transcriptional regulator
HLBS07_11760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLBS07_11770	COG4136	ATPase activity
HLBS07_11780	COG4135	transport system, permease component
HLBS07_11790	COG4134	Bacterial extracellular solute-binding protein
HLBS07_11840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HLBS07_11880	COG1061	Type III restriction enzyme res subunit
HLBS07_11890	COG1187	pseudouridine synthase activity
HLBS07_11910	COG2814	Major facilitator Superfamily
HLBS07_11930	COG0702	epimerase
HLBS07_11940	COG0534	Mate efflux family protein
HLBS07_11980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLBS07_12000	COG1960	acyl-CoA dehydrogenase activity
HLBS07_12010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLBS07_12020	COG2985	domain, Protein
HLBS07_12020	COG3273	potassium ion transport
HLBS07_12030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLBS07_12060	COG1737	Transcriptional regulator
HLBS07_12070	COG0076	glutamate decarboxylase activity
HLBS07_12090	COG2431	L-lysine efflux transmembrane transporter activity
HLBS07_12110	COG3070	regulator of competence-specific genes
HLBS07_12140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLBS07_12140	COG4191	Histidine kinase
HLBS07_12160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HLBS07_12180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLBS07_12190	COG4988	ABC transporter
HLBS07_12200	COG0492	ferredoxin-NADP+ reductase activity
HLBS07_12250	COG0471	metal ion transport
HLBS07_12260	COG2949	membrane
HLBS07_12270	COG0281	malic enzyme
HLBS07_12280	COG1643	Atp-dependent helicase
HLBS07_12310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLBS07_12380	COG0247	lactate metabolic process
HLBS07_12380	COG0277	FAD linked oxidase domain protein
HLBS07_12410	COG2986	histidine ammonia-lyase
HLBS07_12420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HLBS07_12430	COG0010	Belongs to the arginase family
HLBS07_12440	COG1228	amidohydrolase
HLBS07_12480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLBS07_12500	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLBS07_12520	COG0393	Putative heavy-metal-binding
HLBS07_12590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLBS07_12600	COG0072	phenylalanine-tRNA ligase activity
HLBS07_12600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLBS07_12620	COG0776	regulation of translation
HLBS07_12640	COG0500	methyltransferase
HLBS07_12650	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HLBS07_12660	COG0295	cytidine deaminase activity
HLBS07_12670	COG1346	cytolysis
HLBS07_12680	COG1380	Effector of murein hydrolase LrgA
HLBS07_12690	COG2925	Exonuclease
HLBS07_12700	COG1823	symporter activity
HLBS07_12710	COG0702	epimerase
HLBS07_12720	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLBS07_12730	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLBS07_12770	COG2988	succinylglutamate desuccinylase activity
HLBS07_12780	COG4139	cobalamin transport
HLBS07_12790	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HLBS07_12840	COG0583	DNA-binding transcription factor activity
HLBS07_12860	COG1451	nucleotide metabolic process
HLBS07_12930	COG3938	Belongs to the proline racemase family
HLBS07_12960	COG2423	ornithine cyclodeaminase activity
HLBS07_12970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLBS07_12980	COG3842	ATPase activity
HLBS07_13000	COG1177	transmembrane transport
HLBS07_13020	COG3291	Pkd domain containing protein
HLBS07_13060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLBS07_13070	COG0601	transmembrane transport
HLBS07_13100	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLBS07_13120	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HLBS07_13140	COG0625	glutathione transferase activity
HLBS07_13370	COG1484	DNA-dependent DNA replication
HLBS07_13430	COG1742	UPF0060 membrane protein
HLBS07_13460	COG1757	Na H antiporter
HLBS07_13470	COG0174	glutamine synthetase
HLBS07_13480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLBS07_13490	COG1396	sequence-specific DNA binding
HLBS07_13490	COG1917	Cupin 2, conserved barrel domain protein
HLBS07_13500	COG1012	belongs to the aldehyde dehydrogenase family
HLBS07_13510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLBS07_13530	COG2957	Belongs to the agmatine deiminase family
HLBS07_13540	COG1012	belongs to the aldehyde dehydrogenase family
HLBS07_13550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLBS07_13560	COG2200	EAL domain
HLBS07_13580	COG1846	Transcriptional regulator
HLBS07_13590	COG2315	Protein conserved in bacteria
HLBS07_13640	COG0745	RESPONSE REGULATOR receiver
HLBS07_13650	COG3850	Histidine kinase
HLBS07_13650	COG2205	protein histidine kinase activity
HLBS07_13650	COG3437	response regulator, receiver
HLBS07_13650	COG4999	Histidine kinase
HLBS07_13680	COG3063	Type IV pilus biogenesis stability protein PilW
HLBS07_13690	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HLBS07_13720	COG1560	Kdo2-lipid A biosynthetic process
HLBS07_13840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLBS07_13930	COG1160	GTP binding
HLBS07_13940	COG1160	GTP binding
HLBS07_13970	COG2916	Histone family protein nucleoid-structuring protein H-NS
HLBS07_14020	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HLBS07_14060	COG1479	Protein of unknown function DUF262
HLBS07_14140	COG2199	diguanylate cyclase activity
HLBS07_14230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLBS07_14240	COG1280	lysine exporter protein (LysE YggA)
HLBS07_14260	COG1115	amino acid carrier protein
HLBS07_14310	COG1368	sulfuric ester hydrolase activity
HLBS07_14320	COG2113	Glycine betaine
HLBS07_14330	COG4176	ABC-type proline glycine betaine transport system permease component
HLBS07_14340	COG4175	Glycine betaine
HLBS07_14370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLBS07_14380	COG0456	acetyltransferase
HLBS07_14390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLBS07_14400	COG0662	Cupin 2, conserved barrel domain protein
HLBS07_14410	COG0527	aspartate kinase activity
HLBS07_14420	COG3119	arylsulfatase activity
HLBS07_14460	COG0641	radical SAM
HLBS07_14490	COG3119	arylsulfatase activity
HLBS07_14560	COG1538	Outer membrane efflux protein
HLBS07_14590	COG1349	DNA-binding transcription factor activity
HLBS07_14600	COG0673	inositol 2-dehydrogenase activity
HLBS07_14610	COG4702	Belongs to the UPF0303 family
HLBS07_14620	COG3706	GGDEF domain
HLBS07_14660	COG0471	metal ion transport
HLBS07_14690	COG5001	Diguanylate cyclase
HLBS07_14690	COG3300	MHYT domain
HLBS07_14720	COG1328	CTP reductase activity
HLBS07_14730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLBS07_14750	COG0861	Integral membrane protein TerC family
HLBS07_14770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLBS07_14790	COG0814	amino acid
HLBS07_14820	COG1120	ATPase activity
HLBS07_14830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLBS07_14850	COG4774	siderophore transport
HLBS07_14870	COG1132	(ABC) transporter
HLBS07_14880	COG1132	(ABC) transporter
HLBS07_14910	COG0583	DNA-binding transcription factor activity
HLBS07_14970	COG0443	Heat shock 70 kDa protein
HLBS07_14980	COG0443	Heat shock 70 kDa protein
HLBS07_15070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLBS07_15080	COG1643	Atp-dependent helicase
HLBS07_15110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLBS07_15130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLBS07_15140	COG1215	transferase activity, transferring glycosyl groups
HLBS07_15150	COG0438	transferase activity, transferring glycosyl groups
HLBS07_15230	COG0438	transferase activity, transferring glycosyl groups
HLBS07_15240	COG0438	transferase activity, transferring glycosyl groups
HLBS07_15250	COG2204	response regulator
HLBS07_15320	COG1793	dna ligase
HLBS07_15340	COG0534	Mate efflux family protein
HLBS07_15350	COG0307	riboflavin synthase, alpha
HLBS07_15370	COG3001	Fructosamine kinase
HLBS07_15380	COG3001	Fructosamine kinase
HLBS07_15400	COG3706	GGDEF domain
HLBS07_15420	COG0791	NLP P60 protein
HLBS07_15490	COG3148	PFAM DTW domain containing protein
HLBS07_15500	COG1940	carbohydrate kinase activity
HLBS07_15520	COG0303	'Molybdopterin
HLBS07_15530	COG0746	molybdenum cofactor guanylyltransferase activity
HLBS07_15540	COG3842	ATPase activity
HLBS07_15570	COG2204	response regulator
HLBS07_15580	COG4191	Histidine kinase
HLBS07_15590	COG0488	(ABC) transporter
HLBS07_15600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLBS07_15660	COG0243	molybdopterin cofactor binding
HLBS07_15660	COG3383	formate dehydrogenase (NAD+) activity
HLBS07_15670	COG0437	4 iron, 4 sulfur cluster binding
HLBS07_15930	COG0004	ammonium transporteR
HLBS07_15950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLBS07_15960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLBS07_15980	COG1177	transmembrane transport
HLBS07_16000	COG3842	ATPase activity
HLBS07_16050	COG0589	response to stress
HLBS07_16060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLBS07_16090	COG2217	Heavy metal translocating P-type atpase
HLBS07_16110	COG2010	Cytochrome c
HLBS07_16140	COG3278	Belongs to the heme-copper respiratory oxidase family
HLBS07_16170	COG0784	Response regulator, receiver
HLBS07_16170	COG2205	protein histidine kinase activity
HLBS07_16220	COG3120	sequence-specific DNA binding
HLBS07_16230	COG1067	ATP-dependent peptidase activity
HLBS07_16240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLBS07_16270	COG0488	(ABC) transporter
HLBS07_16290	COG0116	Belongs to the methyltransferase superfamily
HLBS07_16290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLBS07_16310	COG0167	dihydroorotate dehydrogenase activity
HLBS07_16320	COG2902	Dehydrogenase
HLBS07_16330	COG0308	aminopeptidase N
HLBS07_16360	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HLBS07_16370	COG1956	GAF domain-containing protein
HLBS07_16380	COG1132	(ABC) transporter
HLBS07_16390	COG2995	paraquat-inducible protein a
HLBS07_16400	COG3008	intermembrane lipid transfer
HLBS07_16450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLBS07_16460	COG1666	GTP binding
HLBS07_16480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLBS07_16490	COG4597	amino acid ABC transporter
HLBS07_16500	COG4597	amino acid ABC transporter
HLBS07_16510	COG0765	amino acid transport
HLBS07_16520	COG1126	abc transporter atp-binding protein
HLBS07_16530	COG0670	Belongs to the BI1 family
HLBS07_16550	COG2920	part of a sulfur-relay system
HLBS07_16560	COG1254	Belongs to the acylphosphatase family
HLBS07_16610	COG2885	chlorophyll binding
HLBS07_16660	COG2203	Gaf domain
HLBS07_16660	COG2199	diguanylate cyclase activity
HLBS07_16670	COG1414	Transcriptional regulator
HLBS07_16690	COG0656	L-ascorbic acid biosynthetic process
HLBS07_16700	COG0583	DNA-binding transcription factor activity
HLBS07_16720	COG0583	DNA-binding transcription factor activity
HLBS07_16730	COG2814	Major facilitator Superfamily
HLBS07_16770	COG1335	isochorismatase
HLBS07_16780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLBS07_16810	COG1410	methionine synthase
HLBS07_16810	COG0646	methionine synthase
HLBS07_16820	COG1126	abc transporter atp-binding protein
HLBS07_16830	COG0765	amino acid transport
HLBS07_16840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLBS07_16870	COG0583	DNA-binding transcription factor activity
HLBS07_16910	COG0583	DNA-binding transcription factor activity
HLBS07_16930	COG0583	DNA-binding transcription factor activity
HLBS07_16960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLBS07_16970	COG0602	queuosine metabolic process
HLBS07_16980	COG0561	phosphatase activity
HLBS07_17030	COG2828	Protein conserved in bacteria
HLBS07_17050	COG0372	Belongs to the citrate synthase family
HLBS07_17060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HLBS07_17140	COG0730	response to heat
HLBS07_17150	COG2358	TRAP transporter, solute receptor (TAXI family
HLBS07_17190	COG0457	Tetratricopeptide repeat
HLBS07_17340	COG4790	Type iii secretion
HLBS07_17350	COG4794	Type iii secretion
HLBS07_17360	COG4791	protein targeting
HLBS07_17370	COG4792	protein secretion
HLBS07_17380	COG2207	Transcriptional regulator
HLBS07_17440	COG3177	Filamentation induced by cAMP protein fic
HLBS07_17480	COG4669	(LipO)protein
HLBS07_17620	COG1012	belongs to the aldehyde dehydrogenase family
HLBS07_17630	COG3284	Transcriptional regulator
HLBS07_17670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLBS07_17680	COG0363	glucosamine-6-phosphate deaminase activity
HLBS07_17690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLBS07_17700	COG2207	Transcriptional regulator
HLBS07_17720	COG4565	transcriptional regulatory protein
HLBS07_17730	COG3290	protein histidine kinase activity
HLBS07_17760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_17820	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HLBS07_17840	COG2985	domain, Protein
HLBS07_17900	COG2272	Belongs to the type-B carboxylesterase lipase family
HLBS07_17910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLBS07_17920	COG0729	surface antigen
HLBS07_17940	COG1280	lysine exporter protein (LysE YggA)
HLBS07_17950	COG1280	lysine exporter protein (LysE YggA)
HLBS07_17960	COG5507	3-demethylubiquinone-9 3-methyltransferase
HLBS07_18000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLBS07_18010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLBS07_18020	COG0110	maltose O-acetyltransferase activity
HLBS07_18210	COG2824	Alkylphosphonate utilization operon protein PhnA
HLBS07_18900	COG1280	lysine exporter protein (LysE YggA)
HLBS07_18980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLBS07_19110	COG2852	Protein conserved in bacteria
HLBS07_19270	COG0791	NLP P60 protein
HLBS07_19400	COG2732	(Barnase) inhibitor
HLBS07_19760	COG2732	(Barnase) inhibitor
HLBS07_19940	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLBS07_19990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLBS07_20010	COG3768	UPF0283 membrane protein
HLBS07_20020	COG3106	COG3106 Predicted ATPase
HLBS07_20050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLBS07_20060	COG2205	protein histidine kinase activity
HLBS07_20060	COG0784	Response regulator, receiver
HLBS07_20080	COG0494	nUDIX hydrolase
HLBS07_20090	COG0814	amino acid
HLBS07_20100	COG1760	l-serine dehydratase
HLBS07_20110	COG2200	EAL domain
HLBS07_20130	COG0720	synthase
HLBS07_20140	COG0840	transmembrane signaling receptor activity
HLBS07_20150	COG0017	Asparaginyl-tRNA synthetase
HLBS07_20170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLBS07_20210	COG1448	Aminotransferase
HLBS07_20250	COG0840	transmembrane signaling receptor activity
HLBS07_20260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLBS07_20330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HLBS07_20360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLBS07_20370	COG3108	Peptidase M15
HLBS07_20380	COG2989	Protein conserved in bacteria
HLBS07_20440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLBS07_20460	COG4235	cytochrome complex assembly
HLBS07_20460	COG3088	subunit of a heme lyase
HLBS07_20480	COG1138	Cytochrome C-type biogenesis protein
HLBS07_20490	COG3301	Polysulphide reductase, NrfD
HLBS07_20500	COG0437	4 iron, 4 sulfur cluster binding
HLBS07_20520	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HLBS07_20570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLBS07_20580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLBS07_20640	COG0019	diaminopimelate decarboxylase activity
HLBS07_20670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLBS07_20700	COG0322	excinuclease ABC activity
HLBS07_20710	COG2197	response regulator
HLBS07_20720	COG0417	DNA replication proofreading
HLBS07_20760	COG1187	pseudouridine synthase activity
HLBS07_20780	COG0009	L-threonylcarbamoyladenylate synthase
HLBS07_20790	COG0613	PHP domain protein
HLBS07_20800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLBS07_20810	COG0512	Glutamine amidotransferase of anthranilate synthase
HLBS07_20830	COG0134	indole-3-glycerol-phosphate synthase activity
HLBS07_20830	COG0135	phosphoribosylanthranilate isomerase activity
HLBS07_20850	COG0159	tryptophan synthase activity
HLBS07_20860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLBS07_20870	COG0318	PFAM AMP-dependent synthetase and ligase
HLBS07_20880	COG1301	dicarboxylic acid transport
HLBS07_20920	COG2917	probably involved in intracellular septation
HLBS07_20940	COG2350	Protein conserved in bacteria
HLBS07_20960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLBS07_20970	COG0583	DNA-binding transcription factor activity
HLBS07_21000	COG5001	Diguanylate cyclase
HLBS07_21010	COG1032	radical SAM domain protein
HLBS07_21060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HLBS07_21070	COG0463	Glycosyl transferase, family 2
HLBS07_21080	COG0745	RESPONSE REGULATOR receiver
HLBS07_21090	COG5002	protein histidine kinase activity
HLBS07_21090	COG3850	Histidine kinase
HLBS07_21200	COG0577	efflux transmembrane transporter activity
HLBS07_21200	COG1136	(ABC) transporter
HLBS07_21210	COG0577	efflux transmembrane transporter activity
HLBS07_21230	COG1136	(ABC) transporter
HLBS07_21230	COG0577	efflux transmembrane transporter activity
HLBS07_21250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_21290	COG3118	belongs to the thioredoxin family
HLBS07_21300	COG4232	protein-disulfide reductase activity
HLBS07_21380	COG2863	cytochrome
HLBS07_21390	COG3258	Cytochrome c
HLBS07_21400	COG2995	paraquat-inducible protein a
HLBS07_21410	COG3008	intermembrane lipid transfer
HLBS07_21410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLBS07_21420	COG3008	intermembrane lipid transfer
HLBS07_21420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLBS07_21460	COG4166	transmembrane transport
HLBS07_21480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HLBS07_21490	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HLBS07_21510	COG0539	negative regulation of cytoplasmic translation
HLBS07_21520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLBS07_21530	COG0616	signal peptide processing
HLBS07_21540	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_21570	COG0587	DNA-directed DNA polymerase activity
HLBS07_21580	COG0784	Response regulator, receiver
HLBS07_21580	COG0835	chemotaxis
HLBS07_21590	COG1940	carbohydrate kinase activity
HLBS07_21600	COG0469	pyruvate kinase activity
HLBS07_21610	COG4667	esterase of the alpha-beta hydrolase superfamily
HLBS07_21630	COG0733	neurotransmitter:sodium symporter activity
HLBS07_21650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_21650	COG1263	PTS System
HLBS07_21660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_21660	COG1263	PTS System
HLBS07_21670	COG0084	hydrolase, TatD family'
HLBS07_21680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLBS07_21690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLBS07_21700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLBS07_21760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLBS07_21770	COG0416	fatty acid biosynthetic process
HLBS07_21790	COG1399	metal-binding, possibly nucleic acid-binding protein
HLBS07_21800	COG0424	maF-like protein
HLBS07_21810	COG0564	pseudouridine synthase activity
HLBS07_21820	COG1530	ribonuclease E activity
HLBS07_21830	COG0659	secondary active sulfate transmembrane transporter activity
HLBS07_21840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLBS07_21850	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HLBS07_21870	COG0572	uridine kinase
HLBS07_21940	COG2186	Transcriptional regulator
HLBS07_21950	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLBS07_21960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLBS07_21970	COG0653	protein targeting
HLBS07_21980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLBS07_21990	COG3706	GGDEF domain
HLBS07_22000	COG0366	Alpha amylase catalytic
HLBS07_22010	COG1122	ATPase activity
HLBS07_22020	COG4120	Belongs to the binding-protein-dependent transport system permease family
HLBS07_22040	COG3092	negative regulation of chromosome organization
HLBS07_22050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLBS07_22060	COG0857	belongs to the CobB CobQ family
HLBS07_22060	COG0280	phosphate acetyltransferase
HLBS07_22080	COG0435	Glutathione S-transferase
HLBS07_22100	COG0444	Belongs to the ABC transporter superfamily
HLBS07_22110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLBS07_22120	COG0601	transmembrane transport
HLBS07_22140	COG0314	molybdopterin synthase activity
HLBS07_22150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HLBS07_22160	COG0315	cyclic pyranopterin monophosphate synthase activity
HLBS07_22170	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLBS07_22180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLBS07_22190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLBS07_22200	COG2198	Histidine kinase
HLBS07_22210	COG2204	response regulator
HLBS07_22220	COG0556	nucleotide-excision repair
HLBS07_22230	COG1882	Formate acetyltransferase
HLBS07_22240	COG4657	Part of a membrane complex involved in electron transport
HLBS07_22250	COG2878	Part of a membrane complex involved in electron transport
HLBS07_22260	COG4656	Part of a membrane complex involved in electron transport
HLBS07_22270	COG4656	Part of a membrane complex involved in electron transport
HLBS07_22280	COG4658	electron transport chain
HLBS07_22290	COG4659	FMN binding
HLBS07_22300	COG4660	Part of a membrane complex involved in electron transport
HLBS07_22310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLBS07_22320	COG0346	lactoylglutathione lyase activity
HLBS07_22340	COG2885	chlorophyll binding
HLBS07_22350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLBS07_22360	COG2056	Na+-H+ antiporter family
HLBS07_22400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLBS07_22440	COG1454	alcohol dehydrogenase
HLBS07_22440	COG1012	belongs to the aldehyde dehydrogenase family
HLBS07_22450	COG2095	MarC family integral membrane protein
HLBS07_22460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLBS07_22470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLBS07_22480	COG1757	Na H antiporter
HLBS07_22510	COG3081	Nucleoid-associated protein
HLBS07_22520	COG3082	Protein of unknown function (DUF1414)
HLBS07_22530	COG3083	sulfuric ester hydrolase activity
HLBS07_22540	COG0123	including yeast histone deacetylase and acetoin utilization protein
HLBS07_22570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLBS07_22580	COG0778	Nitroreductase
HLBS07_22600	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLBS07_22600	COG1902	pentaerythritol trinitrate reductase activity
HLBS07_22610	COG0616	signal peptide processing
HLBS07_22620	COG0252	asparaginase activity
HLBS07_22630	COG3139	Protein of unknown function (DUF1315)
HLBS07_22650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLBS07_22660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLBS07_22670	COG0676	glucose-6-phosphate 1-epimerase activity
HLBS07_22690	COG2226	methyltransferase
HLBS07_22720	COG1785	Belongs to the alkaline phosphatase family
HLBS07_22740	COG0346	lactoylglutathione lyase activity
HLBS07_22750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HLBS07_22760	COG0668	transmembrane transport
HLBS07_22770	COG2983	Belongs to the UPF0260 family
HLBS07_22780	COG2261	transglycosylase associated protein
HLBS07_22800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLBS07_22810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLBS07_22840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLBS07_22870	COG0745	RESPONSE REGULATOR receiver
HLBS07_22880	COG0583	DNA-binding transcription factor activity
HLBS07_22890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLBS07_22900	COG1286	toxin biosynthetic process
HLBS07_22910	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HLBS07_22920	COG0285	dihydrofolate synthase activity
HLBS07_22930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLBS07_22940	COG0101	tRNA pseudouridine synthase activity
HLBS07_22960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLBS07_22970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLBS07_22980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLBS07_22990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLBS07_22990	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HLBS07_23000	COG0431	NADPH-dependent FMN reductase
HLBS07_23020	COG3101	peptidyl-lysine hydroxylation
HLBS07_23040	COG2860	membrane
HLBS07_23050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLBS07_23060	COG2890	protein-(glutamine-N5) methyltransferase activity
HLBS07_23080	COG2062	phosphohistidine phosphatase, SixA
HLBS07_23110	COG1024	Enoyl-CoA hydratase
HLBS07_23110	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLBS07_23120	COG0183	Belongs to the thiolase family
HLBS07_23170	COG2067	long-chain fatty acid transport protein
HLBS07_23190	COG3088	subunit of a heme lyase
HLBS07_23190	COG4235	cytochrome complex assembly
HLBS07_23210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLBS07_23220	COG1138	Cytochrome C-type biogenesis protein
HLBS07_23230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HLBS07_23240	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLBS07_23250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLBS07_23260	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLBS07_23270	COG4133	protoheme IX ABC transporter activity
HLBS07_23290	COG0835	chemotaxis
HLBS07_23310	COG1192	Involved in chromosome partitioning
HLBS07_23320	COG2201	protein-glutamate methylesterase activity
HLBS07_23330	COG0784	Response regulator, receiver
HLBS07_23330	COG2198	Histidine kinase
HLBS07_23330	COG0643	Histidine kinase
HLBS07_23340	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HLBS07_23420	COG1987	bacterial-type flagellum assembly
HLBS07_23530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLBS07_23550	COG1677	Flagellar hook-basal body complex protein FliE
HLBS07_23590	COG1516	flagellar protein fliS
HLBS07_23610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HLBS07_23620	COG1334	flagellar protein FlaG
HLBS07_23630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_23640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_23650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_23660	COG2837	iron assimilation
HLBS07_23710	COG1393	Belongs to the ArsC family
HLBS07_23720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLBS07_23750	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HLBS07_23760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLBS07_23780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLBS07_23810	COG4783	chaperone-mediated protein folding
HLBS07_23820	COG1393	Belongs to the ArsC family
HLBS07_23860	COG2233	PERMEase
HLBS07_23870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLBS07_23880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLBS07_23890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLBS07_23900	COG0121	glutamine amidotransferase
HLBS07_23910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HLBS07_23920	COG1960	acyl-CoA dehydrogenase activity
HLBS07_23990	COG0328	RNA-DNA hybrid ribonuclease activity
HLBS07_24000	COG2226	methyltransferase
HLBS07_24010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLBS07_24020	COG0741	lytic transglycosylase activity
HLBS07_24020	COG1388	LysM domain
HLBS07_24040	COG3021	interspecies interaction between organisms
HLBS07_24050	COG0347	Belongs to the P(II) protein family
HLBS07_24080	COG0825	malonyl-CoA metabolic process
HLBS07_24090	COG0587	DNA-directed DNA polymerase activity
HLBS07_24110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLBS07_24120	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLBS07_24140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLBS07_24150	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HLBS07_24170	COG0750	zinc metalloprotease
HLBS07_24180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLBS07_24190	COG0575	Belongs to the CDS family
HLBS07_24200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLBS07_24210	COG0233	cytoplasmic translational termination
HLBS07_24220	COG0528	UMP kinase activity
HLBS07_24230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLBS07_24240	COG0052	Belongs to the universal ribosomal protein uS2 family
HLBS07_24250	COG0024	Methionine aminopeptidase
HLBS07_24260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HLBS07_24280	COG0564	pseudouridine synthase activity
HLBS07_24340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLBS07_24350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLBS07_24400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HLBS07_24410	COG0254	rRNA binding
HLBS07_24420	COG1720	tRNA m6t6A37 methyltransferase activity
HLBS07_24430	COG0442	prolyl-tRNA aminoacylation
HLBS07_24470	COG0733	neurotransmitter:sodium symporter activity
HLBS07_24500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLBS07_24510	COG0514	ATP-dependent DNA helicase (RecQ)
HLBS07_24520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLBS07_24560	COG1477	protein flavinylation
HLBS07_24570	COG2871	sodium ion transport
HLBS07_24580	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HLBS07_24590	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HLBS07_24600	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HLBS07_24610	COG1805	sodium ion transport
HLBS07_24620	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HLBS07_24630	COG0271	Belongs to the BolA IbaG family
HLBS07_24640	COG2813	Specifically methylates the guanine in position
HLBS07_24650	COG3056	Lipoprotein
HLBS07_24690	COG1595	DNA-templated transcription, initiation
HLBS07_24720	COG3248	Nucleoside-binding outer membrane protein
HLBS07_24730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLBS07_24740	COG0693	protein deglycase activity
HLBS07_24750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLBS07_24760	COG3706	GGDEF domain
HLBS07_24770	COG2166	iron-sulfur cluster assembly
HLBS07_24780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLBS07_24790	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HLBS07_24800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HLBS07_24820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLBS07_24820	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLBS07_24860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLBS07_24870	COG1074	ATP-dependent DNA helicase activity
HLBS07_24880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HLBS07_24920	COG3141	response to X-ray
HLBS07_24950	COG2171	N-acyltransferase activity
HLBS07_24960	COG0584	glycerophosphoryl diester phosphodiesterase
HLBS07_24970	COG2271	Major facilitator Superfamily
HLBS07_24980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLBS07_24990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLBS07_25000	COG1349	DNA-binding transcription factor activity
HLBS07_25010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLBS07_25020	COG0598	Magnesium transport protein CorA
HLBS07_25060	COG1609	Transcriptional regulator
HLBS07_25070	COG0583	DNA-binding transcription factor activity
HLBS07_25150	COG1022	Amp-dependent synthetase and ligase
HLBS07_25170	COG0583	DNA-binding transcription factor activity
HLBS07_25180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLBS07_25190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLBS07_25210	COG0560	Phosphoserine phosphatase
HLBS07_25230	COG0813	purine-nucleoside phosphorylase activity
HLBS07_25240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HLBS07_25250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HLBS07_25260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLBS07_25280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLBS07_25290	COG0084	hydrolase, TatD family'
HLBS07_25350	COG3153	acetyltransferase
HLBS07_25360	COG3154	lipid carrier protein
HLBS07_25380	COG0826	peptidase U32
HLBS07_25390	COG0826	peptidase U32
HLBS07_25400	COG0534	Mate efflux family protein
HLBS07_25430	COG1185	polyribonucleotide nucleotidyltransferase activity
HLBS07_25440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLBS07_25450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLBS07_25460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLBS07_25470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLBS07_25480	COG0195	Participates in both transcription termination and antitermination
HLBS07_25490	COG0779	Required for maturation of 30S ribosomal subunits
HLBS07_25500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLBS07_25520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLBS07_25530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLBS07_25540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLBS07_25550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HLBS07_25560	COG1534	Rna-binding protein
HLBS07_25570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLBS07_25580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLBS07_25590	COG2027	D-alanyl-D-alanine carboxypeptidase
HLBS07_25610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLBS07_25620	COG0739	heme binding
HLBS07_25670	COG0628	permease
HLBS07_25690	COG0784	Response regulator, receiver
HLBS07_25690	COG2205	protein histidine kinase activity
HLBS07_25700	COG0747	negative chemotaxis
HLBS07_25720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLBS07_25730	COG0444	Belongs to the ABC transporter superfamily
HLBS07_25740	COG4608	Belongs to the ABC transporter superfamily
HLBS07_25760	COG2971	BadF BadG BcrA BcrD
HLBS07_25790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLBS07_25800	COG3842	ATPase activity
HLBS07_25820	COG1840	ABC-type Fe3 transport system, periplasmic component
HLBS07_25830	COG0004	ammonium transporteR
HLBS07_25850	COG3112	Uncharacterised protein family (UPF0231)
HLBS07_25860	COG1049	propionate catabolic process, 2-methylcitrate cycle
HLBS07_25870	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLBS07_25880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLBS07_25890	COG1643	Atp-dependent helicase
HLBS07_25900	COG1489	DNA binding
HLBS07_25920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLBS07_25940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLBS07_25950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HLBS07_25960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLBS07_25970	COG1560	Kdo2-lipid A biosynthetic process
HLBS07_25980	COG0842	Transport permease protein
HLBS07_25990	COG1131	(ABC) transporter
HLBS07_26000	COG0659	secondary active sulfate transmembrane transporter activity
HLBS07_26010	COG0659	secondary active sulfate transmembrane transporter activity
HLBS07_26020	COG0288	reversible hydration of carbon dioxide
HLBS07_26050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLBS07_26060	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLBS07_26070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HLBS07_26080	COG2186	Transcriptional regulator
HLBS07_26100	COG0157	Belongs to the NadC ModD family
HLBS07_26120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLBS07_26130	COG1459	type II secretion system
HLBS07_26140	COG1459	type II secretion system
HLBS07_26160	COG0237	dephospho-CoA kinase activity
HLBS07_26170	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HLBS07_26180	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HLBS07_26210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLBS07_26220	COG0228	four-way junction DNA binding
HLBS07_26230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLBS07_26240	COG4137	Cytochrome C assembly protein
HLBS07_26250	COG4536	flavin adenine dinucleotide binding
HLBS07_26260	COG1854	S-ribosylhomocysteine lyase activity
HLBS07_26290	COG0612	Peptidase, M16
HLBS07_26300	COG1238	metal cluster binding
HLBS07_26330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HLBS07_26340	COG0511	ligase activity, forming carbon-carbon bonds
HLBS07_26340	COG5016	pyruvate
HLBS07_26350	COG3630	sodium ion export across plasma membrane
HLBS07_26370	COG0527	aspartate kinase activity
HLBS07_26380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLBS07_26390	COG2137	regulation of response to DNA damage stimulus
HLBS07_26400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLBS07_26410	COG1546	Belongs to the CinA family
HLBS07_26420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLBS07_26430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLBS07_26450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HLBS07_26460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLBS07_26480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLBS07_26490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLBS07_26500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HLBS07_26510	COG0148	phosphopyruvate hydratase activity
HLBS07_26520	COG0504	CTP synthase activity
HLBS07_26530	COG3956	TIGRFAM MazG family protein
HLBS07_26540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLBS07_26550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLBS07_26570	COG0736	holo-[acyl-carrier-protein] synthase activity
HLBS07_26580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HLBS07_26590	COG1381	Involved in DNA repair and RecF pathway recombination
HLBS07_26600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLBS07_26620	COG0681	Belongs to the peptidase S26 family
HLBS07_26630	COG0481	GTPase activity
HLBS07_26640	COG3086	response to oxidative stress
HLBS07_26670	COG1595	DNA-templated transcription, initiation
HLBS07_26680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HLBS07_26690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HLBS07_26730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLBS07_26740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLBS07_26750	COG3079	Belongs to the UPF0149 family
HLBS07_26760	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HLBS07_26770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLBS07_26780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLBS07_26790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLBS07_26810	COG0583	DNA-binding transcription factor activity
HLBS07_26840	COG0668	transmembrane transport
HLBS07_26850	COG0191	fructose-bisphosphate aldolase activity
HLBS07_26880	COG4771	TonB-dependent receptor
HLBS07_26890	COG0583	DNA-binding transcription factor activity
HLBS07_26900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLBS07_26910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLBS07_26930	COG3091	SprT-like family
HLBS07_26950	COG2356	endonuclease I
HLBS07_26960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLBS07_26970	COG0189	ligase activity
HLBS07_26980	COG1678	Uncharacterized ACR, COG1678
HLBS07_26990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLBS07_27020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLBS07_27030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLBS07_27040	COG0762	integral membrane protein
HLBS07_27050	COG1872	DUF167
HLBS07_27070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HLBS07_27080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLBS07_27090	COG2066	Belongs to the glutaminase family
HLBS07_27110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLBS07_27130	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HLBS07_27150	COG0840	transmembrane signaling receptor activity
HLBS07_27170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLBS07_27180	COG1609	Transcriptional regulator
HLBS07_27190	COG3394	polysaccharide catabolic process
HLBS07_27200	COG1486	melibiose metabolic process
HLBS07_27210	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLBS07_27220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLBS07_27240	COG0726	polysaccharide deacetylase
HLBS07_27470	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_27510	COG0795	lipopolysaccharide-transporting ATPase activity
HLBS07_27520	COG0795	lipopolysaccharide-transporting ATPase activity
HLBS07_27530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLBS07_27540	COG2927	DNA polymerase III (CHI subunit)
HLBS07_27550	COG0525	valine-tRNA ligase activity
HLBS07_27570	COG0456	acetyltransferase
HLBS07_27620	COG0540	Belongs to the ATCase OTCase family
HLBS07_27630	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HLBS07_27640	COG0251	oxidation-reduction process
HLBS07_27650	COG0204	Acyl-transferase
HLBS07_27660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLBS07_27670	COG5007	Belongs to the BolA IbaG family
HLBS07_27690	COG2854	intermembrane phospholipid transfer
HLBS07_27700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLBS07_27710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLBS07_27720	COG1127	ABC transporter
HLBS07_27740	COG0517	IMP dehydrogenase activity
HLBS07_27740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLBS07_27760	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HLBS07_27770	COG1137	ATPase activity
HLBS07_27790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLBS07_27800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLBS07_27810	COG1660	Displays ATPase and GTPase activities
HLBS07_27820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLBS07_27830	COG2239	Acts as a magnesium transporter
HLBS07_27840	COG0312	modulator of DNA gyrase
HLBS07_27850	COG3028	Belongs to the UPF0307 family
HLBS07_27860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLBS07_27870	COG0564	pseudouridine synthase activity
HLBS07_27880	COG0564	pseudouridine synthase activity
HLBS07_27900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLBS07_27910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HLBS07_27920	COG0312	modulator of DNA gyrase
HLBS07_27930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLBS07_27940	COG3164	Protein of unknown function
HLBS07_27960	COG0424	maF-like protein
HLBS07_27970	COG0424	maF-like protein
HLBS07_27980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HLBS07_27990	COG1792	Involved in formation and maintenance of cell shape
HLBS07_28000	COG1077	Cell shape determining protein MreB Mrl
HLBS07_28070	COG2165	general secretion pathway protein
HLBS07_28090	COG1459	type II secretion system
HLBS07_28100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLBS07_28120	COG3267	Type II secretory pathway component ExeA
HLBS07_28120	COG3409	Peptidoglycan-binding domain 1 protein
HLBS07_28130	COG1450	Type ii and iii secretion system protein
HLBS07_28170	COG2200	EAL domain
HLBS07_28170	COG2199	diguanylate cyclase activity
HLBS07_28180	COG0629	single-stranded DNA binding
HLBS07_28210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLBS07_28230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLBS07_28240	COG0527	aspartate kinase activity
HLBS07_28250	COG0646	methionine synthase
HLBS07_28250	COG1410	methionine synthase
HLBS07_28280	COG0175	sulfate reduction
HLBS07_28290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLBS07_28300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLBS07_28340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLBS07_28350	COG0735	belongs to the Fur family
HLBS07_28370	COG0166	Belongs to the GPI family
HLBS07_28380	COG0432	Pfam Uncharacterised protein family UPF0047
HLBS07_28390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLBS07_28440	COG2965	DNA replication, synthesis of RNA primer
HLBS07_28450	COG0360	Binds together with S18 to 16S ribosomal RNA
HLBS07_28460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLBS07_28470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HLBS07_28490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLBS07_28500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLBS07_28560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HLBS07_28580	COG0678	peroxiredoxin activity
HLBS07_28580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLBS07_28590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLBS07_28600	COG0165	Argininosuccinate lyase
HLBS07_28600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLBS07_28610	COG0137	argininosuccinate synthase activity
HLBS07_28630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLBS07_28650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HLBS07_28670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLBS07_28680	COG0527	aspartate kinase activity
HLBS07_28680	COG0460	homoserine dehydrogenase
HLBS07_28690	COG0626	cystathionine gamma-synthase activity
HLBS07_28700	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HLBS07_28710	COG0281	malic enzyme
HLBS07_28730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLBS07_28740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLBS07_28780	COG2923	Belongs to the DsrF TusC family
HLBS07_28790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HLBS07_28800	COG2964	Protein conserved in bacteria
HLBS07_28810	COG0545	Peptidyl-prolyl cis-trans isomerase
HLBS07_28840	COG1446	asparaginase
HLBS07_28850	COG1047	Peptidyl-prolyl cis-trans
HLBS07_28880	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLBS07_28890	COG0488	(ABC) transporter
HLBS07_28910	COG0429	hydrolase of the alpha beta-hydrolase fold
HLBS07_28930	COG3954	Phosphoribulokinase
HLBS07_28940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLBS07_28980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLBS07_28990	COG0512	Glutamine amidotransferase of anthranilate synthase
HLBS07_29020	COG0180	Tryptophanyl-tRNA synthetase
HLBS07_29030	COG0546	phosphoglycolate phosphatase activity
HLBS07_29040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLBS07_29050	COG0557	exoribonuclease II activity
HLBS07_29060	COG1959	2 iron, 2 sulfur cluster binding
HLBS07_29070	COG1017	nitric oxide dioxygenase activity
HLBS07_29070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLBS07_29080	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HLBS07_29090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLBS07_29100	COG0330	HflC and HflK could
HLBS07_29110	COG0330	HflC and HflK could
HLBS07_29120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLBS07_29140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLBS07_29150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLBS07_29170	COG0802	atpase or kinase
HLBS07_29180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLBS07_29190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLBS07_29200	COG1162	GTPase activity
HLBS07_29210	COG0688	phosphatidylethanolamine metabolic process
HLBS07_29220	COG3273	potassium ion transport
HLBS07_29220	COG0471	metal ion transport
HLBS07_29240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLBS07_29250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLBS07_29260	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HLBS07_29270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLBS07_29280	COG1045	serine acetyltransferase
HLBS07_29290	COG4942	peptidase
HLBS07_29330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HLBS07_29340	COG1053	succinate dehydrogenase
HLBS07_29350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLBS07_29360	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HLBS07_29370	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HLBS07_29400	COG1509	lysine 2,3-aminomutase activity
HLBS07_29410	COG1285	pathogenesis
HLBS07_29430	COG0459	protein refolding
HLBS07_29450	COG0534	Mate efflux family protein
HLBS07_29460	COG0205	6-phosphofructokinase activity
HLBS07_29470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLBS07_29480	COG3678	ATP-independent chaperone mediated protein folding
HLBS07_29490	COG0745	RESPONSE REGULATOR receiver
HLBS07_29510	COG2205	protein histidine kinase activity
HLBS07_29530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLBS07_29540	COG3030	protein affecting phage T7 exclusion by the F plasmid
HLBS07_29550	COG1027	Aspartate ammonia-lyase
HLBS07_29560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLBS07_29570	COG4232	protein-disulfide reductase activity
HLBS07_29590	COG3263	regulation of cellular component size
HLBS07_29600	COG3263	regulation of cellular component size
HLBS07_29620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLBS07_29670	COG2814	Major facilitator Superfamily
HLBS07_29700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLBS07_29710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLBS07_29720	COG0511	ligase activity, forming carbon-carbon bonds
HLBS07_29730	COG0439	Biotin carboxylase
HLBS07_29740	COG2264	protein methyltransferase activity
HLBS07_29750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLBS07_29760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HLBS07_29780	COG0488	(ABC) transporter
HLBS07_29790	COG1982	Orn Lys Arg decarboxylase major
HLBS07_29800	COG0531	amino acid
HLBS07_29810	COG3710	Transcriptional regulator
HLBS07_29820	COG0789	Transcriptional regulator
HLBS07_29830	COG0138	bifunctional purine biosynthesis protein purh
HLBS07_29850	COG0151	Belongs to the GarS family
HLBS07_29880	COG1253	flavin adenine dinucleotide binding
HLBS07_29890	COG3068	Protein conserved in bacteria
HLBS07_29910	COG1573	uracil-dna glycosylase
HLBS07_29920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HLBS07_29930	COG2816	NAD+ diphosphatase activity
HLBS07_29940	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HLBS07_29950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLBS07_29960	COG0085	RNA polymerase activity
HLBS07_29970	COG0222	ribosome binding
HLBS07_29980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLBS07_30010	COG0250	Participates in transcription elongation, termination and antitermination
HLBS07_30020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLBS07_30030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLBS07_30050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HLBS07_30050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HLBS07_30060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLBS07_30080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLBS07_30120	COG4206	TonB-dependent receptor
HLBS07_30220	COG3339	Conserved Protein
HLBS07_30260	COG2003	Belongs to the UPF0758 family
HLBS07_30390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLBS07_30400	COG0534	Mate efflux family protein
HLBS07_30410	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLBS07_30420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLBS07_30430	COG2937	Belongs to the GPAT DAPAT family
HLBS07_30440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLBS07_30450	COG3161	chorismate lyase activity
HLBS07_30460	COG1580	Controls the rotational direction of flagella during chemotaxis
HLBS07_30470	COG0705	Rhomboid family
HLBS07_30480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLBS07_30500	COG2177	Part of the ABC transporter FtsEX involved in
HLBS07_30510	COG2884	Cell division ATP-binding protein ftsE
HLBS07_30520	COG0552	protein localization to endoplasmic reticulum
HLBS07_30530	COG0742	ribosomal rna small subunit methyltransferase
HLBS07_30550	COG2095	MarC family integral membrane protein
HLBS07_30630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLBS07_30640	COG0640	Transcriptional regulator
HLBS07_30650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HLBS07_30660	COG1280	lysine exporter protein (LysE YggA)
HLBS07_30670	COG1280	lysine exporter protein (LysE YggA)
HLBS07_30680	COG2267	carboxylic ester hydrolase activity
HLBS07_30690	COG0561	phosphatase activity
HLBS07_30720	COG3148	PFAM DTW domain containing protein
HLBS07_30730	COG2199	diguanylate cyclase activity
HLBS07_30730	COG2200	EAL domain
HLBS07_30730	COG3287	FIST C domain
HLBS07_30740	COG2199	diguanylate cyclase activity
HLBS07_30740	COG2200	EAL domain
HLBS07_30740	COG3287	FIST C domain
HLBS07_30750	COG1011	Hydrolase
HLBS07_30760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLBS07_30790	COG0019	diaminopimelate decarboxylase activity
HLBS07_30800	COG0019	diaminopimelate decarboxylase activity
HLBS07_30810	COG1965	Belongs to the frataxin family
HLBS07_30830	COG3072	Adenylate cyclase
HLBS07_30840	COG0181	hydroxymethylbilane synthase activity
HLBS07_30850	COG1587	Uroporphyrinogen-III synthase
HLBS07_30870	COG2959	enzyme of heme biosynthesis
HLBS07_30880	COG3071	HemY protein
HLBS07_30900	COG0633	Ferredoxin
HLBS07_30910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLBS07_30940	COG3118	belongs to the thioredoxin family
HLBS07_30950	COG0513	Belongs to the DEAD box helicase family
HLBS07_30960	COG0248	Ppx GppA phosphatase
HLBS07_30980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HLBS07_31000	COG0514	ATP-dependent DNA helicase (RecQ)
HLBS07_31010	COG2962	Rard protein
HLBS07_31030	COG1280	lysine exporter protein (LysE YggA)
HLBS07_31040	COG0405	Gamma-glutamyltransferase
HLBS07_31050	COG0210	DNA helicase
HLBS07_31070	COG3220	belongs to the UPF0276 family
HLBS07_31130	COG0006	proline dipeptidase activity
HLBS07_31130	COG0006	proline dipeptidase activity
HLBS07_31170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLBS07_31210	COG2132	Multicopper oxidase
HLBS07_31220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLBS07_31260	COG0009	L-threonylcarbamoyladenylate synthase
HLBS07_31270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLBS07_31280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLBS07_31290	COG0551	DNA topoisomerase type I activity
HLBS07_31300	COG2922	Belongs to the Smg family
HLBS07_31310	COG0758	DNA mediated transformation
HLBS07_31330	COG0242	peptide deformylase activity
HLBS07_31340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLBS07_31350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLBS07_31350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLBS07_31360	COG0569	domain protein
HLBS07_31370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLBS07_31390	COG1272	protein, Hemolysin III
HLBS07_31400	COG4326	sporulation control protein
HLBS07_31410	COG3084	Protein conserved in bacteria
HLBS07_31430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLBS07_31440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLBS07_31450	COG0204	Acyl-transferase
HLBS07_31480	COG0606	chelatase, subunit chli
HLBS07_31500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLBS07_31510	COG0758	DNA mediated transformation
HLBS07_31600	COG0606	chelatase, subunit chli
HLBS07_31620	COG3978	acetolactate synthase activity
HLBS07_31630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLBS07_31640	COG0129	dihydroxy-acid dehydratase activity
HLBS07_31660	COG0583	DNA-binding transcription factor activity
HLBS07_31670	COG2814	Major facilitator Superfamily
HLBS07_31680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLBS07_31690	COG0765	amino acid transport
HLBS07_31710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HLBS07_31720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLBS07_31730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLBS07_31740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLBS07_31750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLBS07_31760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLBS07_31780	COG0356	it plays a direct role in the translocation of protons across the membrane
HLBS07_31790	COG3312	ion transport
HLBS07_31800	COG1475	DNA binding
HLBS07_31810	COG1192	Involved in chromosome partitioning
HLBS07_31820	COG0357	Ribosomal RNA small subunit methyltransferase G
HLBS07_31830	COG0445	tRNA wobble uridine modification
HLBS07_31840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLBS07_31860	COG0706	membrane insertase activity
HLBS07_31870	COG0594	ribonuclease P activity
HLBS07_31890	COG1126	abc transporter atp-binding protein
HLBS07_31920	COG1902	pentaerythritol trinitrate reductase activity
HLBS07_31920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLBS07_31930	COG0109	protoheme IX farnesyltransferase activity
HLBS07_31940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HLBS07_31950	COG1845	cytochrome c oxidase, subunit III
HLBS07_31960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLBS07_31970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLBS07_31980	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_32000	COG1024	Enoyl-CoA hydratase
HLBS07_32010	COG1024	Enoyl-CoA hydratase
HLBS07_32050	COG0183	Belongs to the thiolase family
HLBS07_32060	COG0183	Belongs to the thiolase family
HLBS07_32090	COG1960	acyl-CoA dehydrogenase activity
HLBS07_32100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLBS07_32110	COG1024	Enoyl-CoA hydratase
HLBS07_32160	COG2095	MarC family integral membrane protein
HLBS07_32200	COG0523	cobalamin synthesis protein
HLBS07_32220	COG0739	heme binding
HLBS07_32230	COG2988	succinylglutamate desuccinylase activity
HLBS07_32240	COG0523	cobalamin synthesis protein
HLBS07_32260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLBS07_32290	COG0730	response to heat
HLBS07_32330	COG1073	alpha beta
HLBS07_32340	COG1073	alpha beta
HLBS07_32360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLBS07_32380	COG2200	EAL domain
HLBS07_32380	COG2203	Gaf domain
HLBS07_32380	COG2199	diguanylate cyclase activity
HLBS07_32390	COG0513	Belongs to the DEAD box helicase family
HLBS07_32400	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HLBS07_32460	COG1119	ATPase activity
HLBS07_32470	COG2200	EAL domain
HLBS07_32510	COG0513	Belongs to the DEAD box helicase family
HLBS07_32520	COG0523	cobalamin synthesis protein
HLBS07_32540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HLBS07_32560	COG1278	Cold shock
HLBS07_32580	COG0133	tryptophan synthase activity
HLBS07_32600	COG4628	conserved protein (DUF2132)
HLBS07_32610	COG0513	Belongs to the DEAD box helicase family
HLBS07_32620	COG2814	Major facilitator Superfamily
HLBS07_32650	COG3530	Putative quorum-sensing-regulated virulence factor
HLBS07_32700	COG3186	Phenylalanine-4-hydroxylase
HLBS07_32720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLBS07_32730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLBS07_32780	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HLBS07_32790	COG1454	alcohol dehydrogenase
HLBS07_32800	COG2133	pyrroloquinoline quinone binding
HLBS07_32820	COG0783	Belongs to the Dps family
HLBS07_32830	COG0840	transmembrane signaling receptor activity
HLBS07_32910	COG0784	Response regulator, receiver
HLBS07_32910	COG2205	protein histidine kinase activity
HLBS07_32920	COG1538	Outer membrane efflux protein
HLBS07_32940	COG1132	(ABC) transporter
HLBS07_32970	COG2199	diguanylate cyclase activity
HLBS07_32980	COG3036	rescue of stalled ribosome
HLBS07_32990	COG1278	Cold shock
HLBS07_33050	COG0545	Peptidyl-prolyl cis-trans isomerase
HLBS07_33060	COG0109	protoheme IX farnesyltransferase activity
HLBS07_33070	COG1612	heme a metabolic process
HLBS07_33110	COG1845	cytochrome c oxidase, subunit III
HLBS07_33120	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HLBS07_33130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLBS07_33140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLBS07_33150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLBS07_33170	COG1280	lysine exporter protein (LysE YggA)
HLBS07_33210	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLBS07_33250	COG0697	spore germination
HLBS07_33290	COG2814	Major facilitator Superfamily
HLBS07_33300	COG0583	DNA-binding transcription factor activity
HLBS07_33320	COG5001	Diguanylate cyclase
HLBS07_33330	COG0739	heme binding
HLBS07_33360	COG3314	Sporulation integral membrane protein YlbJ
HLBS07_33390	COG0814	amino acid
HLBS07_33440	COG4989	oxidoreductase activity
HLBS07_33500	COG1733	regulation of RNA biosynthetic process
HLBS07_33530	COG0798	PFAM Bile acid sodium symporter
HLBS07_33550	COG1881	PFAM PEBP family protein
HLBS07_33580	COG1131	(ABC) transporter
HLBS07_33590	COG0842	Transport permease protein
HLBS07_33610	COG3383	formate dehydrogenase (NAD+) activity
HLBS07_33650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLBS07_33700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLBS07_33720	COG2067	long-chain fatty acid transport protein
HLBS07_33740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_33760	COG1505	serine-type exopeptidase activity
HLBS07_33770	COG0488	(ABC) transporter
HLBS07_33780	COG0589	response to stress
HLBS07_33790	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLBS07_33840	COG0366	Alpha amylase catalytic
HLBS07_33850	COG0789	Transcriptional regulator
HLBS07_33860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLBS07_33880	COG4934	collagen metabolic process
HLBS07_33900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLBS07_33910	COG0583	DNA-binding transcription factor activity
HLBS07_33950	COG2610	gluconate transmembrane transporter activity
HLBS07_33960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLBS07_33970	COG3622	Belongs to the hyi family
HLBS07_33980	COG0235	Class ii aldolase
HLBS07_33990	COG3395	kinase activity
HLBS07_34000	COG2084	Dehydrogenase
HLBS07_34010	COG1349	DNA-binding transcription factor activity
HLBS07_34030	COG0747	negative chemotaxis
HLBS07_34040	COG4608	Belongs to the ABC transporter superfamily
HLBS07_34050	COG0444	Belongs to the ABC transporter superfamily
HLBS07_34060	COG0534	Mate efflux family protein
HLBS07_34070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLBS07_34080	COG0835	chemotaxis
HLBS07_34080	COG0784	Response regulator, receiver
HLBS07_34100	COG0748	coenzyme F420 binding
HLBS07_34110	COG3721	Heme iron utilization protein
HLBS07_34130	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HLBS07_34140	COG0811	peptide transport
HLBS07_34150	COG0848	biopolymer transport protein
HLBS07_34170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLBS07_34180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLBS07_34270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLBS07_34290	COG3217	Mosc domain protein beta barrel domain protein
HLBS07_34290	COG0633	Ferredoxin
HLBS07_34290	COG0633	Ferredoxin
HLBS07_34290	COG3217	Mosc domain protein beta barrel domain protein
HLBS07_34300	COG0401	homolog of Blt101
HLBS07_34310	COG0418	dihydroorotase activity
HLBS07_34320	COG2354	Protein conserved in bacteria
HLBS07_34340	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLBS07_34350	COG4605	iron ion homeostasis
HLBS07_34360	COG4607	ABC-type enterochelin transport system periplasmic component
HLBS07_34370	COG4774	siderophore transport
HLBS07_34380	COG2375	cellular response to nickel ion
HLBS07_34380	COG1132	(ABC) transporter
HLBS07_34440	COG3833	ABC-type maltose transport systems, permease component
HLBS07_34450	COG1175	transmembrane transport
HLBS07_34470	COG3842	ATPase activity
HLBS07_34480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLBS07_34510	COG0489	protein tyrosine kinase activity
HLBS07_34510	COG3206	protein involved in exopolysaccharide biosynthesis
HLBS07_34540	COG0438	transferase activity, transferring glycosyl groups
HLBS07_34590	COG3097	Belongs to the UPF0267 family
HLBS07_34600	COG1309	transcriptional regulator
HLBS07_34610	COG2130	NADP-dependent
HLBS07_34630	COG0753	catalase activity
HLBS07_34640	COG2084	Dehydrogenase
HLBS07_34700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLBS07_34710	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HLBS07_34730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLBS07_34740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLBS07_34750	COG1012	belongs to the aldehyde dehydrogenase family
HLBS07_34770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLBS07_34780	COG0583	DNA-binding transcription factor activity
HLBS07_34790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLBS07_34800	COG0569	domain protein
HLBS07_34820	COG2205	protein histidine kinase activity
HLBS07_34820	COG2205	protein histidine kinase activity
HLBS07_34830	COG1132	(ABC) transporter
HLBS07_34840	COG4774	siderophore transport
HLBS07_34850	COG1120	ATPase activity
HLBS07_34860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLBS07_34930	COG2197	response regulator
HLBS07_34960	COG0714	Associated with various cellular activities
HLBS07_34990	COG2304	oxidoreductase activity
HLBS07_35020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLBS07_35030	COG0581	inorganic phosphate transmembrane transporter activity
HLBS07_35040	COG0573	inorganic phosphate transmembrane transporter activity
HLBS07_35100	COG4771	TonB-dependent receptor
HLBS07_35110	COG1770	oligopeptidase
HLBS07_35120	COG0513	Belongs to the DEAD box helicase family
HLBS07_35140	COG1376	ErfK ybiS ycfS ynhG family protein
HLBS07_35140	COG1388	LysM domain
HLBS07_35150	COG0415	Belongs to the DNA photolyase family
HLBS07_35160	COG0789	Transcriptional regulator
HLBS07_35170	COG3272	Protein of unknown function (DUF1722)
HLBS07_35180	COG0813	purine-nucleoside phosphorylase activity
HLBS07_35250	COG1566	PFAM secretion protein HlyD family protein
HLBS07_35260	COG4720	Psort location CytoplasmicMembrane, score
HLBS07_35270	COG1122	ATPase activity
HLBS07_35310	COG0348	domain, Protein
HLBS07_35320	COG0437	4 iron, 4 sulfur cluster binding
HLBS07_35330	COG1247	-acetyltransferase
HLBS07_35380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLBS07_35400	COG1067	ATP-dependent peptidase activity
HLBS07_35420	COG4172	Belongs to the ABC transporter superfamily
HLBS07_35430	COG1505	serine-type exopeptidase activity
HLBS07_35440	COG1505	serine-type exopeptidase activity
HLBS07_35450	COG0583	DNA-binding transcription factor activity
HLBS07_35460	COG1620	l-lactate permease
HLBS07_35470	COG1304	FMN binding
HLBS07_35490	COG0668	transmembrane transport
HLBS07_35570	COG1063	alcohol dehydrogenase
HLBS07_35580	COG0156	8-amino-7-oxononanoate synthase activity
HLBS07_35590	COG3300	MHYT domain
HLBS07_35590	COG5001	Diguanylate cyclase
HLBS07_35640	COG0745	RESPONSE REGULATOR receiver
HLBS07_35690	COG0346	lactoylglutathione lyase activity
HLBS07_35790	COG1157	protein secretion by the type III secretion system
HLBS07_35810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLBS07_35890	COG1987	bacterial-type flagellum assembly
HLBS07_35900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLBS07_35930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLBS07_35950	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HLBS07_35960	COG1516	flagellar protein fliS
HLBS07_35990	COG1580	Controls the rotational direction of flagella during chemotaxis
HLBS07_36000	COG1191	sigma factor activity
HLBS07_36010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLBS07_36020	COG1360	Flagellar Motor Protein
HLBS07_36080	COG1882	Formate acetyltransferase
HLBS07_36090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLBS07_36100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLBS07_36130	COG2205	protein histidine kinase activity
HLBS07_36140	COG0745	RESPONSE REGULATOR receiver
HLBS07_36160	COG0454	-acetyltransferase
HLBS07_36180	COG2814	Major facilitator Superfamily
HLBS07_36270	COG0628	permease
HLBS07_36280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HLBS07_36320	COG4628	conserved protein (DUF2132)
HLBS07_36330	COG0583	DNA-binding transcription factor activity
HLBS07_36390	COG1686	Belongs to the peptidase S11 family
HLBS07_36410	COG1054	Belongs to the UPF0176 family
HLBS07_36430	COG0415	Belongs to the DNA photolyase family
HLBS07_36440	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HLBS07_36450	COG3397	chitin binding
HLBS07_36460	COG4667	esterase of the alpha-beta hydrolase superfamily
HLBS07_36470	COG2095	MarC family integral membrane protein
HLBS07_36510	COG0489	protein tyrosine kinase activity
HLBS07_36510	COG3206	protein involved in exopolysaccharide biosynthesis
HLBS07_36540	COG0583	DNA-binding transcription factor activity
HLBS07_36560	COG1301	dicarboxylic acid transport
HLBS07_36590	COG3339	Conserved Protein
HLBS07_36600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLBS07_36610	COG0700	Nucleoside recognition
HLBS07_36620	COG3366	ferrous iron transmembrane transporter activity
HLBS07_36640	COG0366	Alpha amylase catalytic
HLBS07_36650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLBS07_36660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLBS07_36670	COG1640	4-alpha-glucanotransferase
HLBS07_36680	COG0058	SHG alpha-glucan phosphorylase activity
HLBS07_36690	COG2909	trisaccharide binding
HLBS07_36720	COG1999	signal sequence binding
HLBS07_36730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_36730	COG1263	PTS System
HLBS07_36740	COG1162	GTPase activity
HLBS07_36750	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HLBS07_36760	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HLBS07_36800	COG2356	endonuclease I
HLBS07_36850	COG4580	involved in the transport of maltose and maltodextrins
HLBS07_36870	COG1760	l-serine dehydratase
HLBS07_36960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLBS07_36980	COG1609	Transcriptional regulator
HLBS07_36990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLBS07_37010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLBS07_37010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLBS07_37040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLBS07_37050	COG1609	Transcriptional regulator
HLBS07_37070	COG2814	Major facilitator Superfamily
HLBS07_37110	COG0739	heme binding
HLBS07_37130	COG0612	Peptidase, M16
HLBS07_37140	COG0840	transmembrane signaling receptor activity
HLBS07_37150	COG1120	ATPase activity
HLBS07_37160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLBS07_37170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLBS07_37180	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLBS07_37190	COG4772	TonB-dependent receptor
HLBS07_37240	COG4264	IucA IucC family
HLBS07_37250	COG0019	diaminopimelate decarboxylase activity
HLBS07_37260	COG1653	transport
HLBS07_37310	COG0826	peptidase U32
HLBS07_37330	COG1136	(ABC) transporter
HLBS07_37340	COG0577	efflux transmembrane transporter activity
HLBS07_37430	COG1764	response to oxidative stress
HLBS07_37440	COG1846	Transcriptional regulator
HLBS07_37460	COG3634	alkyl hydroperoxide reductase activity
HLBS07_37570	COG2258	MOSC domain
HLBS07_37580	COG0513	Belongs to the DEAD box helicase family
HLBS07_37600	COG1132	(ABC) transporter
HLBS07_37690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLBS07_37700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLBS07_37750	COG0259	pyridoxamine-phosphate oxidase activity
HLBS07_37840	COG4166	transmembrane transport
HLBS07_37870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HLBS07_37880	COG1263	PTS System
HLBS07_37880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_37890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLBS07_37930	COG1444	tRNA N-acetyltransferase activity
HLBS07_37940	COG1444	tRNA N-acetyltransferase activity
HLBS07_37990	COG4608	Belongs to the ABC transporter superfamily
HLBS07_38000	COG0444	Belongs to the ABC transporter superfamily
HLBS07_38020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLBS07_38020	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HLBS07_38070	COG0772	Belongs to the SEDS family
HLBS07_38090	COG1136	(ABC) transporter
HLBS07_38130	COG3275	phosphorelay sensor kinase activity
HLBS07_38140	COG3279	Response regulator of the LytR AlgR family
HLBS07_38150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLBS07_38190	COG0786	glutamate:sodium symporter activity
HLBS07_38210	COG1131	(ABC) transporter
HLBS07_38220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLBS07_38230	COG0786	glutamate:sodium symporter activity
HLBS07_38250	COG0363	glucosamine-6-phosphate deaminase activity
HLBS07_38290	COG1741	Belongs to the pirin family
HLBS07_38300	COG2259	Doxx family
HLBS07_38320	COG2169	Transcriptional regulator
HLBS07_38320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLBS07_38330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLBS07_38350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLBS07_38400	COG0596	Alpha beta hydrolase
HLBS07_38430	COG3123	guanosine phosphorylase activity
HLBS07_38450	COG5001	Diguanylate cyclase
HLBS07_38470	COG0534	Mate efflux family protein
HLBS07_38480	COG0564	pseudouridine synthase activity
HLBS07_38510	COG0583	DNA-binding transcription factor activity
HLBS07_38520	COG0561	phosphatase activity
HLBS07_38540	COG2199	diguanylate cyclase activity
HLBS07_38570	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HLBS07_38580	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HLBS07_38590	COG0583	DNA-binding transcription factor activity
HLBS07_38600	COG2375	cellular response to nickel ion
HLBS07_38660	COG1357	PFAM Pentapeptide repeats (8 copies)
HLBS07_38670	COG3047	cAMP biosynthetic process
HLBS07_38790	COG3835	regulator
HLBS07_38800	COG2610	gluconate transmembrane transporter activity
HLBS07_38810	COG1929	Belongs to the glycerate kinase type-1 family
HLBS07_38820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLBS07_38860	COG0456	acetyltransferase
HLBS07_38890	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_38900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLBS07_38910	COG3005	denitrification pathway
HLBS07_38920	COG0243	molybdopterin cofactor binding
HLBS07_38960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLBS07_38970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLBS07_38980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLBS07_38990	COG1116	anion transmembrane transporter activity
HLBS07_39000	COG0351	phosphomethylpyrimidine kinase
HLBS07_39020	COG0312	modulator of DNA gyrase
HLBS07_39030	COG0312	modulator of DNA gyrase
HLBS07_39040	COG1901	pseudouridine methyltransferase
HLBS07_39090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLBS07_39110	COG0584	glycerophosphoryl diester phosphodiesterase
HLBS07_39120	COG0745	RESPONSE REGULATOR receiver
HLBS07_39160	COG0811	peptide transport
HLBS07_39170	COG0811	peptide transport
HLBS07_39180	COG0848	biopolymer transport protein
HLBS07_39280	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLBS07_39290	COG1121	(ABC) transporter
HLBS07_39300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLBS07_39330	COG1770	oligopeptidase
HLBS07_39340	COG2814	Major facilitator Superfamily
HLBS07_39350	COG0010	Belongs to the arginase family
HLBS07_39360	COG1166	arginine decarboxylase activity
HLBS07_39380	COG0189	ligase activity
HLBS07_39380	COG4067	protein conserved in archaea
HLBS07_39390	COG0189	ligase activity
HLBS07_39430	COG0583	DNA-binding transcription factor activity
HLBS07_39460	COG2723	6-phospho-beta-galactosidase activity
HLBS07_39470	COG4191	Histidine kinase
HLBS07_39490	COG3706	GGDEF domain
HLBS07_39530	COG0579	oxidoreductase
HLBS07_39540	COG3179	chitinase
HLBS07_39570	COG1294	oxidase, subunit
HLBS07_39580	COG1271	oxidase subunit
HLBS07_39600	COG3033	Beta-eliminating lyase
HLBS07_39620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLBS07_39650	COG3706	GGDEF domain
HLBS07_39680	COG3706	GGDEF domain
HLBS07_39690	COG0415	Belongs to the DNA photolyase family
HLBS07_39700	COG3046	protein related to deoxyribodipyrimidine photolyase
HLBS07_39720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLBS07_39720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLBS07_39730	COG1765	OsmC-like protein
HLBS07_39740	COG0110	maltose O-acetyltransferase activity
HLBS07_39810	COG1011	Hydrolase
HLBS07_39840	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HLBS07_39860	COG2067	long-chain fatty acid transport protein
HLBS07_39870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLBS07_39880	COG0577	efflux transmembrane transporter activity
HLBS07_39880	COG1136	(ABC) transporter
HLBS07_39890	COG0577	efflux transmembrane transporter activity
HLBS07_39890	COG1136	(ABC) transporter
HLBS07_39900	COG1538	Outer membrane efflux protein
HLBS07_39930	COG1309	transcriptional regulator
HLBS07_39940	COG3240	lipase activity
HLBS07_40000	COG1609	Transcriptional regulator
HLBS07_40020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLBS07_40040	COG1840	ABC-type Fe3 transport system, periplasmic component
HLBS07_40050	COG3842	ATPase activity
HLBS07_40110	COG2990	Protein conserved in bacteria
HLBS07_40150	COG2866	Carboxypeptidase
HLBS07_40180	COG0583	DNA-binding transcription factor activity
HLBS07_40210	COG1760	l-serine dehydratase
HLBS07_40220	COG1760	l-serine dehydratase
HLBS07_40260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLBS07_40270	COG0741	lytic transglycosylase activity
HLBS07_40310	COG1815	bacterial-type flagellum-dependent cell motility
HLBS07_40320	COG1558	bacterial-type flagellum-dependent cell motility
HLBS07_40350	COG4787	bacterial-type flagellum-dependent cell motility
HLBS07_40360	COG4786	Flagellar basal body rod
HLBS07_40370	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HLBS07_40380	COG1706	bacterial-type flagellum-dependent cell motility
HLBS07_40400	COG1256	bacterial-type flagellum assembly
HLBS07_40400	COG4786	Flagellar basal body rod
HLBS07_40450	COG1304	FMN binding
HLBS07_40480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLBS07_40490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLBS07_40500	COG0459	protein refolding
HLBS07_40520	COG1280	lysine exporter protein (LysE YggA)
HLBS07_40560	COG1309	transcriptional regulator
HLBS07_40580	COG4303	Ethanolamine ammonia lyase large subunit
HLBS07_40590	COG4302	ethanolamine ammonia-lyase activity
HLBS07_40610	COG0531	amino acid
HLBS07_40620	COG2070	2-Nitropropane dioxygenase
HLBS07_40640	COG1349	DNA-binding transcription factor activity
HLBS07_40670	COG1335	isochorismatase
HLBS07_40690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLBS07_40740	COG0583	DNA-binding transcription factor activity
HLBS07_40770	COG3713	MltA-interacting MipA family protein
HLBS07_40780	COG3015	lipoprotein NlpE involved in copper resistance
HLBS07_40790	COG3448	diguanylate cyclase activity
HLBS07_40790	COG4175	Glycine betaine
HLBS07_40800	COG4176	ABC-type proline glycine betaine transport system permease component
HLBS07_40810	COG1342	Belongs to the UPF0251 family
HLBS07_40870	COG4948	Mandelate Racemase Muconate Lactonizing
HLBS07_40890	COG0583	DNA-binding transcription factor activity
HLBS07_40960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLBS07_41060	COG3842	ATPase activity
HLBS07_41120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLBS07_41170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLBS07_41180	COG2197	response regulator
HLBS07_41210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HLBS07_41220	COG0252	asparaginase activity
HLBS07_41230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLBS07_41240	COG0583	DNA-binding transcription factor activity
HLBS07_41270	COG3122	Protein conserved in bacteria
HLBS07_41280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLBS07_41290	COG1012	belongs to the aldehyde dehydrogenase family
HLBS07_41300	COG1522	sequence-specific DNA binding
HLBS07_41310	COG3608	succinylglutamate desuccinylase aspartoacylase
HLBS07_41320	COG0006	proline dipeptidase activity
HLBS07_41330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLBS07_41350	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_41370	COG1063	alcohol dehydrogenase
HLBS07_41380	COG1902	pentaerythritol trinitrate reductase activity
HLBS07_41410	COG0583	DNA-binding transcription factor activity
HLBS07_41430	COG0513	Belongs to the DEAD box helicase family
HLBS07_41510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLBS07_41520	COG2207	Transcriptional regulator
HLBS07_41520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLBS07_41530	COG0583	DNA-binding transcription factor activity
HLBS07_41540	COG0300	oxidoreductase activity
HLBS07_41570	COG3746	phosphate-selective porin O and P
HLBS07_41600	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_41650	COG1263	PTS System
HLBS07_41650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_41660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLBS07_41670	COG1621	beta-fructofuranosidase activity
HLBS07_41680	COG0625	glutathione transferase activity
HLBS07_41700	COG1686	Belongs to the peptidase S11 family
HLBS07_41720	COG0678	peroxiredoxin activity
HLBS07_41720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLBS07_41730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLBS07_41760	COG1278	Cold shock
HLBS07_41770	COG1741	Belongs to the pirin family
HLBS07_41780	COG4667	esterase of the alpha-beta hydrolase superfamily
HLBS07_41820	COG2194	sulfuric ester hydrolase activity
HLBS07_41830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLBS07_41840	COG2205	protein histidine kinase activity
HLBS07_41850	COG0745	RESPONSE REGULATOR receiver
HLBS07_41880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLBS07_41920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLBS07_41940	COG2814	Major facilitator Superfamily
HLBS07_41960	COG1418	mRNA catabolic process
HLBS07_41970	COG0402	S-adenosylhomocysteine deaminase activity
HLBS07_41980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLBS07_41990	COG2239	Acts as a magnesium transporter
HLBS07_42000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLBS07_42010	COG1566	PFAM secretion protein HlyD family protein
HLBS07_42080	COG0745	RESPONSE REGULATOR receiver
HLBS07_42090	COG2205	protein histidine kinase activity
HLBS07_42120	COG0531	amino acid
HLBS07_42140	COG0583	DNA-binding transcription factor activity
HLBS07_42200	COG5002	protein histidine kinase activity
HLBS07_42200	COG0784	Response regulator, receiver
HLBS07_42200	COG2205	protein histidine kinase activity
HLBS07_42240	COG3132	Protein of unknown function, DUF480
HLBS07_42250	COG2827	Endonuclease containing a URI domain
HLBS07_42260	COG1879	ABC-type sugar transport system periplasmic component
HLBS07_42270	COG2205	protein histidine kinase activity
HLBS07_42270	COG0784	Response regulator, receiver
HLBS07_42280	COG1846	Transcriptional regulator
HLBS07_42390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLBS07_42400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLBS07_42420	COG1280	lysine exporter protein (LysE YggA)
HLBS07_42440	COG0183	Belongs to the thiolase family
HLBS07_42460	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLBS07_42480	COG3005	denitrification pathway
HLBS07_42500	COG0243	molybdopterin cofactor binding
HLBS07_42520	COG3850	Histidine kinase
HLBS07_42530	COG2197	response regulator
HLBS07_42560	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLBS07_42600	COG0840	transmembrane signaling receptor activity
HLBS07_42620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLBS07_42650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLBS07_42660	COG2814	Major facilitator Superfamily
HLBS07_42670	COG0840	transmembrane signaling receptor activity
HLBS07_42680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLBS07_42690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLBS07_42720	COG2897	thiosulfate sulfurtransferase activity
HLBS07_42790	COG0038	chloride channel
HLBS07_42820	COG4989	oxidoreductase activity
HLBS07_42850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLBS07_42850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLBS07_42880	COG3537	Alpha-1,2-mannosidase
HLBS07_42890	COG3537	Alpha-1,2-mannosidase
HLBS07_42910	COG3537	Alpha-1,2-mannosidase
HLBS07_42920	COG3537	Alpha-1,2-mannosidase
HLBS07_42930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLBS07_42960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLBS07_42960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLBS07_42960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLBS07_42970	COG2207	Transcriptional regulator
HLBS07_42990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLBS07_43000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLBS07_43050	COG0668	transmembrane transport
HLBS07_43080	COG0739	heme binding
HLBS07_43200	COG3501	Rhs element vgr protein
HLBS07_43260	COG0515	serine threonine protein kinase
HLBS07_43330	COG1522	sequence-specific DNA binding
HLBS07_43480	COG2814	Major facilitator Superfamily
HLBS07_43500	COG0583	DNA-binding transcription factor activity
HLBS07_43510	COG4221	oxidoreductase activity
HLBS07_43520	COG0589	response to stress
HLBS07_43540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLBS07_43540	COG2111	Na H antiporter
HLBS07_43550	COG1006	Multisubunit Na H antiporter MnhC subunit
HLBS07_43560	COG0651	ATP synthesis coupled electron transport
HLBS07_43570	COG1863	multisubunit Na H antiporter MnhE subunit
HLBS07_43580	COG2212	antiporter activity
HLBS07_43590	COG1320	monovalent cation:proton antiporter activity
HLBS07_43600	COG2188	Transcriptional regulator
HLBS07_43610	COG1486	melibiose metabolic process
HLBS07_43620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLBS07_43620	COG1263	PTS System
HLBS07_43630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLBS07_43680	COG1022	Amp-dependent synthetase and ligase
HLBS07_43740	COG0500	methyltransferase
HLBS07_43780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLBS07_43810	COG3527	Alpha-acetolactate decarboxylase
HLBS07_43830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLBS07_43850	COG1294	oxidase, subunit
HLBS07_43860	COG1271	oxidase subunit
HLBS07_43870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLBS07_43890	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HLBS07_43890	COG3264	Mechanosensitive ion channel
HLBS07_43930	COG4770	biotin carboxylase activity
HLBS07_43950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLBS07_43960	COG1960	acyl-CoA dehydrogenase activity
HLBS07_43980	COG0183	Belongs to the thiolase family
HLBS07_44000	COG1960	acyl-CoA dehydrogenase activity
HLBS07_44010	COG1024	Enoyl-CoA hydratase
HLBS07_44040	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_44060	COG1309	transcriptional regulator
HLBS07_44070	COG1012	belongs to the aldehyde dehydrogenase family
HLBS07_44100	COG4176	ABC-type proline glycine betaine transport system permease component
HLBS07_44110	COG0517	IMP dehydrogenase activity
HLBS07_44110	COG4175	Glycine betaine
HLBS07_44140	COG0330	HflC and HflK could
HLBS07_44170	COG0784	Response regulator, receiver
HLBS07_44170	COG2205	protein histidine kinase activity
HLBS07_44190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLBS07_44200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLBS07_44290	COG5001	Diguanylate cyclase
HLBS07_44300	COG1869	D-ribose catabolic process
HLBS07_44310	COG1129	ABC transporter
HLBS07_44320	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLBS07_44330	COG1879	ABC-type sugar transport system periplasmic component
HLBS07_44340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLBS07_44350	COG1609	Transcriptional regulator
HLBS07_44370	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HLBS07_44380	COG0813	purine-nucleoside phosphorylase activity
HLBS07_44400	COG4607	ABC-type enterochelin transport system periplasmic component
HLBS07_44410	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLBS07_44420	COG4605	iron ion homeostasis
HLBS07_44430	COG4604	ABC transporter, ATP-binding protein
HLBS07_44440	COG0789	Transcriptional regulator
HLBS07_44460	COG4771	TonB-dependent receptor
HLBS07_44460	COG1629	transport
HLBS07_44520	COG1289	transmembrane transporter activity
HLBS07_44530	COG0210	DNA helicase
HLBS07_44540	COG1803	Methylglyoxal synthase
HLBS07_44550	COG1879	ABC-type sugar transport system periplasmic component
HLBS07_44570	COG2205	protein histidine kinase activity
HLBS07_44570	COG2198	Histidine kinase
HLBS07_44570	COG0784	Response regulator, receiver
HLBS07_44600	COG3119	arylsulfatase activity
HLBS07_44620	COG3119	arylsulfatase activity
HLBS07_44630	COG0641	radical SAM
HLBS07_44640	COG0714	Associated with various cellular activities
HLBS07_44710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLBS07_44720	COG0583	DNA-binding transcription factor activity
HLBS07_44730	COG1597	lipid kinase activity
HLBS07_44740	COG3111	PFAM Bacterial OB fold (BOF) protein
HLBS07_44790	COG3069	C4-dicarboxylate transmembrane transporter activity
HLBS07_44810	COG1214	PFAM Peptidase M22, glycoprotease
HLBS07_44810	COG0456	acetyltransferase
HLBS07_44860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLBS07_44870	COG2205	protein histidine kinase activity
HLBS07_44870	COG0784	Response regulator, receiver
HLBS07_44880	COG3300	MHYT domain
HLBS07_44880	COG5001	Diguanylate cyclase
HLBS07_44890	COG2197	response regulator
HLBS07_44900	COG3706	GGDEF domain
HLBS07_44920	COG2197	response regulator
HLBS07_44930	COG0784	Response regulator, receiver
HLBS07_44930	COG0835	chemotaxis
HLBS07_44960	COG2962	Rard protein
HLBS07_45010	COG2076	Multidrug Resistance protein
HLBS07_45080	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HLBS07_45090	COG5642	Protein of unknown function (DUF2384)
HLBS07_45130	COG1902	pentaerythritol trinitrate reductase activity
HLBS07_45140	COG0346	lactoylglutathione lyase activity
HLBS07_45180	COG2239	Acts as a magnesium transporter
HLBS07_45250	COG0242	peptide deformylase activity
HLBS07_45340	COG2176	DNA-directed DNA polymerase activity
HLBS07_45430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLBS07_45440	COG0697	spore germination
HLBS07_45460	COG0583	DNA-binding transcription factor activity
HLBS07_45470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLBS07_45480	COG0346	lactoylglutathione lyase activity
HLBS07_45500	COG0509	glycine decarboxylation via glycine cleavage system
HLBS07_45510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLBS07_45530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLBS07_45590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLBS07_45590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLBS07_45590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLBS07_45600	COG1105	Belongs to the carbohydrate kinase PfkB family
HLBS07_45610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLBS07_45610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLBS07_45620	COG1609	Transcriptional regulator
HLBS07_45650	COG2203	Gaf domain
HLBS07_45650	COG2200	EAL domain
HLBS07_45650	COG2199	diguanylate cyclase activity
HLBS07_45660	COG0765	amino acid transport
HLBS07_45670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLBS07_45680	COG0765	amino acid transport
HLBS07_45690	COG1126	abc transporter atp-binding protein
HLBS07_45700	COG1979	alcohol dehydrogenase
HLBS07_45710	COG2207	Transcriptional regulator
HLBS07_45730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLBS07_45740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HLBS07_45750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HLBS07_45760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLBS07_45790	COG0546	phosphoglycolate phosphatase activity
HLBS07_45800	COG0840	transmembrane signaling receptor activity
HLBS07_45820	COG0513	Belongs to the DEAD box helicase family
HLBS07_45870	COG3038	cytochrome b561
HLBS07_45880	COG2353	YceI-like domain
HLBS07_45890	COG2116	formate transmembrane transporter activity
HLBS07_45910	COG0583	DNA-binding transcription factor activity
HLBS07_45930	COG3593	DNA synthesis involved in DNA repair
HLBS07_45940	COG0737	Belongs to the 5'-nucleotidase family
HLBS07_45990	COG2267	carboxylic ester hydrolase activity
HLBS07_46000	COG2067	long-chain fatty acid transport protein
HLBS07_46030	COG2050	protein possibly involved in aromatic compounds catabolism
HLBS07_46050	COG4533	DNA binding
HLBS07_46120	COG3300	MHYT domain
HLBS07_46120	COG5001	Diguanylate cyclase
HLBS07_46130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLBS07_46150	COG4181	ATPase activity
HLBS07_46160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HLBS07_46280	COG3617	BRO family, N-terminal domain
HLBS07_46370	COG4974	Belongs to the 'phage' integrase family
HLBS07_46390	COG1984	allophanate hydrolase subunit 2
HLBS07_46400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLBS07_46410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HLBS07_46430	COG3447	MASE1 domain protein
HLBS07_46430	COG5002	protein histidine kinase activity
HLBS07_46430	COG5001	Diguanylate cyclase
HLBS07_46460	COG0583	DNA-binding transcription factor activity
HLBS07_46470	COG0045	succinate-CoA ligase (ADP-forming) activity
HLBS07_46470	COG1042	CoA-binding domain protein
HLBS07_46470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLBS07_46500	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLBS07_46520	COG0023	Translation Initiation Factor
HLBS07_46670	COG0583	DNA-binding transcription factor activity
HLBS07_46700	COG3140	Belongs to the UPF0181 family
HLBS07_46750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HLBS07_46760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HLBS07_46800	COG5001	Diguanylate cyclase
HLBS07_46800	COG2203	Gaf domain
HLBS07_46800	COG3706	GGDEF domain
HLBS07_46800	COG4251	negative regulation of phosphorylation
HLBS07_46820	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HLBS07_46830	COG4149	molybdate abc transporter
HLBS07_46840	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLBS07_46860	COG3111	PFAM Bacterial OB fold (BOF) protein
HLBS07_46880	COG4067	protein conserved in archaea
HLBS07_46880	COG0189	ligase activity
HLBS07_46900	COG2207	Transcriptional regulator
HLBS07_46910	COG0534	Mate efflux family protein
HLBS07_46920	COG0602	queuosine metabolic process
HLBS07_46930	COG1328	CTP reductase activity
HLBS07_46990	COG1794	racemase activity, acting on amino acids and derivatives
HLBS07_47000	COG0384	phenazine biosynthesis protein PhzF
HLBS07_47030	COG0243	molybdopterin cofactor binding
HLBS07_47040	COG0583	DNA-binding transcription factor activity
HLBS07_47050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLBS07_47070	COG2197	response regulator
HLBS07_47080	COG3851	Histidine kinase
HLBS07_47090	COG2271	Major facilitator Superfamily
HLBS07_47140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLBS07_47150	COG3118	belongs to the thioredoxin family
HLBS07_47220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLBS07_47260	COG2116	formate transmembrane transporter activity
HLBS07_47280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLBS07_47290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLBS07_47310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLBS07_47350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLBS07_47400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLBS07_47430	COG0277	FAD linked oxidase domain protein
HLBS07_47440	COG0583	DNA-binding transcription factor activity
HLBS07_47460	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HLBS07_47490	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HLBS07_47510	COG1288	antiporter activity
HLBS07_47530	COG3040	lipid binding
HLBS07_47550	COG0419	ATPase involved in DNA repair
HLBS07_47560	COG0420	3'-5' exonuclease activity
HLBS07_47720	COG0631	protein serine/threonine phosphatase activity
HLBS07_47790	COG0515	serine threonine protein kinase
HLBS07_47790	COG2815	serine threonine protein kinase
HLBS07_47830	COG0745	RESPONSE REGULATOR receiver
HLBS07_47890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLBS07_47890	COG2146	nitrite reductase [NAD(P)H] activity
HLBS07_47900	COG1116	anion transmembrane transporter activity
HLBS07_47910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLBS07_47920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLBS07_47920	COG1116	anion transmembrane transporter activity
HLBS07_47930	COG3707	response regulator
HLBS07_47960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLBS07_47960	COG1648	precorrin-2 dehydrogenase activity
HLBS07_47970	COG0243	molybdopterin cofactor binding
HLBS07_47990	COG0814	amino acid
HLBS07_48110	COG2847	Copper chaperone PCu(A)C
HLBS07_48120	COG1028	Short-chain dehydrogenase reductase Sdr
HLBS07_48130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLBS07_48160	COG0800	Aldolase
HLBS07_48170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLBS07_48180	COG1917	Cupin 2, conserved barrel domain protein
HLBS07_48280	COG2186	Transcriptional regulator
HLBS07_48290	COG2186	Transcriptional regulator
HLBS07_48300	COG0517	IMP dehydrogenase activity
HLBS07_48310	COG2176	DNA-directed DNA polymerase activity
HLBS07_48320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLBS07_48440	COG4160	amino acid transport
HLBS07_48450	COG4215	(ABC) transporter
HLBS07_48460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLBS07_48470	COG1126	abc transporter atp-binding protein
HLBS07_48530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLBS07_48550	COG1012	belongs to the aldehyde dehydrogenase family