locus-tag	class	description
K6748_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6748_00010	COG0592	DNA-directed DNA polymerase activity
K6748_00020	COG0187	DNA topoisomerase II activity
K6748_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
K6748_00035	COG3977	Valine--pyruvate aminotransferase
K6748_00040	COG0366	Alpha amylase catalytic
K6748_00055	COG2119	membrane
K6748_00065	COG0425	Belongs to the sulfur carrier protein TusA family
K6748_00080	COG0604	alcohol dehydrogenase
K6748_00085	COG0183	Belongs to the thiolase family
K6748_00095	COG1739	Uncharacterized protein family UPF0029
K6748_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6748_00150	COG2132	Multicopper oxidase
K6748_00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6748_00175	COG2104	thiamine diphosphate biosynthetic process
K6748_00190	COG0006	proline dipeptidase activity
K6748_00190	COG0006	proline dipeptidase activity
K6748_00220	COG3220	belongs to the UPF0276 family
K6748_00230	COG0210	DNA helicase
K6748_00235	COG0405	Gamma-glutamyltransferase
K6748_00240	COG1280	lysine exporter protein (LysE YggA)
K6748_00250	COG2962	Rard protein
K6748_00255	COG0514	ATP-dependent DNA helicase (RecQ)
K6748_00265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6748_00275	COG0248	Ppx GppA phosphatase
K6748_00280	COG0513	Belongs to the DEAD box helicase family
K6748_00285	COG3118	belongs to the thioredoxin family
K6748_00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6748_00305	COG0633	Ferredoxin
K6748_00345	COG3071	HemY protein
K6748_00350	COG2959	enzyme of heme biosynthesis
K6748_00355	COG1587	Uroporphyrinogen-III synthase
K6748_00360	COG0181	hydroxymethylbilane synthase activity
K6748_00365	COG3072	Adenylate cyclase
K6748_00370	COG1965	Belongs to the frataxin family
K6748_00380	COG0019	diaminopimelate decarboxylase activity
K6748_00395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6748_00400	COG1011	Hydrolase
K6748_00405	COG2199	diguanylate cyclase activity
K6748_00405	COG2200	EAL domain
K6748_00405	COG3287	FIST C domain
K6748_00425	COG0561	phosphatase activity
K6748_00430	COG2267	carboxylic ester hydrolase activity
K6748_00435	COG1280	lysine exporter protein (LysE YggA)
K6748_00440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6748_00445	COG0640	Transcriptional regulator
K6748_00450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6748_00490	COG2095	MarC family integral membrane protein
K6748_00500	COG0742	ribosomal rna small subunit methyltransferase
K6748_00505	COG0552	protein localization to endoplasmic reticulum
K6748_00510	COG2884	Cell division ATP-binding protein ftsE
K6748_00515	COG2177	Part of the ABC transporter FtsEX involved in
K6748_00525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6748_00530	COG0705	Rhomboid family
K6748_00535	COG1580	Controls the rotational direction of flagella during chemotaxis
K6748_00540	COG3161	chorismate lyase activity
K6748_00545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6748_00550	COG2937	Belongs to the GPAT DAPAT family
K6748_00555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6748_00560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6748_00565	COG0534	Mate efflux family protein
K6748_00570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6748_00590	COG4206	TonB-dependent receptor
K6748_00670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6748_00680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6748_00685	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6748_00685	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6748_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6748_00720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6748_00725	COG0250	Participates in transcription elongation, termination and antitermination
K6748_00740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6748_00745	COG0222	ribosome binding
K6748_00750	COG0085	RNA polymerase activity
K6748_00755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6748_00760	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6748_00765	COG2816	NAD+ diphosphatase activity
K6748_00770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6748_00775	COG1573	uracil-dna glycosylase
K6748_00785	COG3068	Protein conserved in bacteria
K6748_00790	COG1253	flavin adenine dinucleotide binding
K6748_00805	COG0151	Belongs to the GarS family
K6748_00815	COG0789	Transcriptional regulator
K6748_00820	COG3710	Transcriptional regulator
K6748_00825	COG0531	amino acid
K6748_00830	COG1982	Orn Lys Arg decarboxylase major
K6748_00880	COG0488	(ABC) transporter
K6748_00890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6748_00895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6748_00900	COG2264	protein methyltransferase activity
K6748_00905	COG0439	Biotin carboxylase
K6748_00910	COG0511	ligase activity, forming carbon-carbon bonds
K6748_00915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6748_00920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6748_00935	COG2814	Major facilitator Superfamily
K6748_00960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6748_00970	COG3263	regulation of cellular component size
K6748_00980	COG4232	protein-disulfide reductase activity
K6748_00985	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6748_00990	COG1027	Aspartate ammonia-lyase
K6748_00995	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6748_01000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6748_01010	COG2205	protein histidine kinase activity
K6748_01015	COG0745	RESPONSE REGULATOR receiver
K6748_01020	COG3678	ATP-independent chaperone mediated protein folding
K6748_01030	COG0205	6-phosphofructokinase activity
K6748_01035	COG0534	Mate efflux family protein
K6748_01045	COG0459	protein refolding
K6748_01055	COG1285	pathogenesis
K6748_01060	COG1509	lysine 2,3-aminomutase activity
K6748_01075	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6748_01080	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6748_01085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6748_01090	COG1053	succinate dehydrogenase
K6748_01095	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6748_01115	COG4942	peptidase
K6748_01120	COG1045	serine acetyltransferase
K6748_01125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6748_01130	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6748_01135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6748_01140	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6748_01150	COG0471	metal ion transport
K6748_01155	COG0688	phosphatidylethanolamine metabolic process
K6748_01160	COG1162	GTPase activity
K6748_01165	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6748_01230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6748_01235	COG0802	atpase or kinase
K6748_01245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6748_01250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6748_01260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6748_01265	COG0330	HflC and HflK could
K6748_01270	COG0330	HflC and HflK could
K6748_01280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6748_01285	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K6748_01290	COG1017	nitric oxide dioxygenase activity
K6748_01290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6748_01295	COG1959	2 iron, 2 sulfur cluster binding
K6748_01300	COG0557	exoribonuclease II activity
K6748_01305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6748_01310	COG0546	phosphoglycolate phosphatase activity
K6748_01315	COG0180	Tryptophanyl-tRNA synthetase
K6748_01330	COG0512	Glutamine amidotransferase of anthranilate synthase
K6748_01335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6748_01355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6748_01360	COG3954	Phosphoribulokinase
K6748_01370	COG0429	hydrolase of the alpha beta-hydrolase fold
K6748_01380	COG0488	(ABC) transporter
K6748_01385	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6748_01400	COG1047	Peptidyl-prolyl cis-trans
K6748_01405	COG1446	asparaginase
K6748_01420	COG0545	Peptidyl-prolyl cis-trans isomerase
K6748_01425	COG2964	Protein conserved in bacteria
K6748_01430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6748_01435	COG2923	Belongs to the DsrF TusC family
K6748_01455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6748_01460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6748_01475	COG0281	malic enzyme
K6748_01480	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6748_01485	COG0626	cystathionine gamma-synthase activity
K6748_01490	COG0460	homoserine dehydrogenase
K6748_01490	COG0527	aspartate kinase activity
K6748_01495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6748_01505	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6748_01515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6748_01525	COG0137	argininosuccinate synthase activity
K6748_01530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6748_01530	COG0165	Argininosuccinate lyase
K6748_01540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6748_01545	COG0678	peroxiredoxin activity
K6748_01545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6748_01555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6748_01585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6748_01590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6748_01600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6748_01605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6748_01610	COG0360	Binds together with S18 to 16S ribosomal RNA
K6748_01615	COG2965	DNA replication, synthesis of RNA primer
K6748_01640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6748_01645	COG0432	Pfam Uncharacterised protein family UPF0047
K6748_01650	COG0166	Belongs to the GPI family
K6748_01660	COG0735	belongs to the Fur family
K6748_01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6748_01685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6748_01690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6748_01695	COG0175	sulfate reduction
K6748_01755	COG1410	methionine synthase
K6748_01755	COG0646	methionine synthase
K6748_01760	COG0527	aspartate kinase activity
K6748_01765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6748_01775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6748_01790	COG0629	single-stranded DNA binding
K6748_01795	COG2199	diguanylate cyclase activity
K6748_01795	COG2200	EAL domain
K6748_01815	COG1450	Type ii and iii secretion system protein
K6748_01820	COG3267	Type II secretory pathway component ExeA
K6748_01820	COG3409	Peptidoglycan-binding domain 1 protein
K6748_01830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6748_01835	COG1459	type II secretion system
K6748_01845	COG2165	general secretion pathway protein
K6748_01880	COG1077	Cell shape determining protein MreB Mrl
K6748_01885	COG1792	Involved in formation and maintenance of cell shape
K6748_01890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6748_01895	COG0424	maF-like protein
K6748_01905	COG3164	Protein of unknown function
K6748_01910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6748_01915	COG0312	modulator of DNA gyrase
K6748_01920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6748_01925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6748_01935	COG0564	pseudouridine synthase activity
K6748_01940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6748_01945	COG3028	Belongs to the UPF0307 family
K6748_01950	COG0312	modulator of DNA gyrase
K6748_01955	COG2239	Acts as a magnesium transporter
K6748_01960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6748_01965	COG1660	Displays ATPase and GTPase activities
K6748_01970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6748_01975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6748_01985	COG1137	ATPase activity
K6748_01990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6748_02000	COG0517	IMP dehydrogenase activity
K6748_02000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6748_02010	COG1127	ABC transporter
K6748_02015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6748_02020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6748_02025	COG2854	intermembrane phospholipid transfer
K6748_02035	COG5007	Belongs to the BolA IbaG family
K6748_02040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6748_02045	COG0204	Acyl-transferase
K6748_02050	COG0251	oxidation-reduction process
K6748_02055	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6748_02060	COG0540	Belongs to the ATCase OTCase family
K6748_02090	COG0456	acetyltransferase
K6748_02100	COG0525	valine-tRNA ligase activity
K6748_02105	COG2927	DNA polymerase III (CHI subunit)
K6748_02110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6748_02115	COG0795	lipopolysaccharide-transporting ATPase activity
K6748_02120	COG0795	lipopolysaccharide-transporting ATPase activity
K6748_02135	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_02145	COG0726	polysaccharide deacetylase
K6748_02150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6748_02155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6748_02160	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6748_02165	COG1486	melibiose metabolic process
K6748_02170	COG3394	polysaccharide catabolic process
K6748_02175	COG1609	Transcriptional regulator
K6748_02180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6748_02255	COG0840	transmembrane signaling receptor activity
K6748_02300	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K6748_02310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6748_02320	COG2066	Belongs to the glutaminase family
K6748_02325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6748_02330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6748_02340	COG1872	DUF167
K6748_02345	COG0762	integral membrane protein
K6748_02350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6748_02355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6748_02370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6748_02375	COG1678	Uncharacterized ACR, COG1678
K6748_02380	COG0189	ligase activity
K6748_02385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6748_02390	COG2356	endonuclease I
K6748_02395	COG3091	SprT-like family
K6748_02405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6748_02410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6748_02415	COG0583	DNA-binding transcription factor activity
K6748_02420	COG4771	TonB-dependent receptor
K6748_02435	COG0191	fructose-bisphosphate aldolase activity
K6748_02440	COG0668	transmembrane transport
K6748_02455	COG0583	DNA-binding transcription factor activity
K6748_02465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6748_02470	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6748_02475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6748_02485	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6748_02490	COG3079	Belongs to the UPF0149 family
K6748_02495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6748_02500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6748_02520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6748_02530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6748_02535	COG1595	DNA-templated transcription, initiation
K6748_02550	COG3086	response to oxidative stress
K6748_02555	COG0481	GTPase activity
K6748_02560	COG0681	Belongs to the peptidase S26 family
K6748_02570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6748_02575	COG1381	Involved in DNA repair and RecF pathway recombination
K6748_02580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6748_02585	COG0736	holo-[acyl-carrier-protein] synthase activity
K6748_02595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6748_02600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6748_02605	COG3956	TIGRFAM MazG family protein
K6748_02610	COG0504	CTP synthase activity
K6748_02615	COG0148	phosphopyruvate hydratase activity
K6748_02620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6748_02625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6748_02630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6748_02640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6748_02645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6748_02660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6748_02665	COG1546	Belongs to the CinA family
K6748_02670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6748_02675	COG2137	regulation of response to DNA damage stimulus
K6748_02680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6748_02685	COG0527	aspartate kinase activity
K6748_02745	COG3630	sodium ion export across plasma membrane
K6748_02750	COG0511	ligase activity, forming carbon-carbon bonds
K6748_02750	COG5016	pyruvate
K6748_02755	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6748_02765	COG1238	metal cluster binding
K6748_02770	COG0612	Peptidase, M16
K6748_02775	COG2918	glutathione biosynthetic process
K6748_02785	COG1854	S-ribosylhomocysteine lyase activity
K6748_02790	COG4536	flavin adenine dinucleotide binding
K6748_02795	COG4137	Cytochrome C assembly protein
K6748_02800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6748_02805	COG0228	four-way junction DNA binding
K6748_02810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6748_02825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K6748_02830	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6748_02835	COG0237	dephospho-CoA kinase activity
K6748_02845	COG1459	type II secretion system
K6748_02850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6748_02860	COG0157	Belongs to the NadC ModD family
K6748_02870	COG2186	Transcriptional regulator
K6748_02875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6748_02880	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6748_02885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6748_02900	COG0288	reversible hydration of carbon dioxide
K6748_02905	COG0659	secondary active sulfate transmembrane transporter activity
K6748_02910	COG1131	(ABC) transporter
K6748_02915	COG0842	Transport permease protein
K6748_02920	COG1560	Kdo2-lipid A biosynthetic process
K6748_02925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6748_02930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6748_02935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6748_02945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6748_02955	COG1489	DNA binding
K6748_02960	COG1643	Atp-dependent helicase
K6748_02965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6748_02970	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6748_02975	COG1049	propionate catabolic process, 2-methylcitrate cycle
K6748_02980	COG3112	Uncharacterised protein family (UPF0231)
K6748_02990	COG0004	ammonium transporteR
K6748_02995	COG1840	ABC-type Fe3 transport system, periplasmic component
K6748_03005	COG3842	ATPase activity
K6748_03010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6748_03025	COG2971	BadF BadG BcrA BcrD
K6748_03035	COG4608	Belongs to the ABC transporter superfamily
K6748_03040	COG0444	Belongs to the ABC transporter superfamily
K6748_03045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6748_03055	COG0747	negative chemotaxis
K6748_03060	COG0784	Response regulator, receiver
K6748_03060	COG2205	protein histidine kinase activity
K6748_03070	COG0628	permease
K6748_03095	COG0739	heme binding
K6748_03100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6748_03110	COG2027	D-alanyl-D-alanine carboxypeptidase
K6748_03115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6748_03120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6748_03125	COG1534	Rna-binding protein
K6748_03130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6748_03135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6748_03140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6748_03145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6748_03150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6748_03165	COG0779	Required for maturation of 30S ribosomal subunits
K6748_03170	COG0195	Participates in both transcription termination and antitermination
K6748_03175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6748_03180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6748_03185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6748_03190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6748_03195	COG1185	polyribonucleotide nucleotidyltransferase activity
K6748_03210	COG0534	Mate efflux family protein
K6748_03215	COG0826	peptidase U32
K6748_03220	COG0826	peptidase U32
K6748_03230	COG3154	lipid carrier protein
K6748_03235	COG3153	acetyltransferase
K6748_03265	COG0084	hydrolase, TatD family'
K6748_03270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6748_03275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6748_03280	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6748_03285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6748_03290	COG0813	purine-nucleoside phosphorylase activity
K6748_03300	COG0560	Phosphoserine phosphatase
K6748_03310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6748_03315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6748_03320	COG0583	DNA-binding transcription factor activity
K6748_03330	COG1022	Amp-dependent synthetase and ligase
K6748_03370	COG0583	DNA-binding transcription factor activity
K6748_03375	COG1609	Transcriptional regulator
K6748_03395	COG0598	Magnesium transport protein CorA
K6748_03400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6748_03405	COG1349	DNA-binding transcription factor activity
K6748_03410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6748_03415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6748_03420	COG2271	Major facilitator Superfamily
K6748_03425	COG0584	glycerophosphoryl diester phosphodiesterase
K6748_03430	COG2171	N-acyltransferase activity
K6748_03445	COG3141	response to X-ray
K6748_03465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6748_03470	COG1074	ATP-dependent DNA helicase activity
K6748_03475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6748_03485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6748_03485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6748_03495	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6748_03500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6748_03505	COG2166	iron-sulfur cluster assembly
K6748_03510	COG3706	GGDEF domain
K6748_03515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6748_03520	COG0693	protein deglycase activity
K6748_03525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6748_03545	COG1595	DNA-templated transcription, initiation
K6748_03565	COG3056	Lipoprotein
K6748_03570	COG2813	Specifically methylates the guanine in position
K6748_03575	COG0271	Belongs to the BolA IbaG family
K6748_03580	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6748_03585	COG1805	sodium ion transport
K6748_03590	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6748_03595	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6748_03600	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6748_03605	COG2871	sodium ion transport
K6748_03610	COG1477	protein flavinylation
K6748_03630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6748_03635	COG0514	ATP-dependent DNA helicase (RecQ)
K6748_03640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6748_03655	COG0733	neurotransmitter:sodium symporter activity
K6748_03675	COG0442	prolyl-tRNA aminoacylation
K6748_03680	COG1720	tRNA m6t6A37 methyltransferase activity
K6748_03685	COG0254	rRNA binding
K6748_03695	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6748_03720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6748_03725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6748_03755	COG3098	single-species biofilm formation
K6748_03760	COG0564	pseudouridine synthase activity
K6748_03770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6748_03775	COG0024	Methionine aminopeptidase
K6748_03780	COG0052	Belongs to the universal ribosomal protein uS2 family
K6748_03785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6748_03790	COG0528	UMP kinase activity
K6748_03795	COG0233	cytoplasmic translational termination
K6748_03800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6748_03805	COG0575	Belongs to the CDS family
K6748_03810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6748_03815	COG0750	zinc metalloprotease
K6748_03825	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6748_03830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6748_03840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6748_03845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6748_03855	COG0587	DNA-directed DNA polymerase activity
K6748_03860	COG0825	malonyl-CoA metabolic process
K6748_03875	COG0347	Belongs to the P(II) protein family
K6748_03880	COG3021	interspecies interaction between organisms
K6748_03890	COG1388	LysM domain
K6748_03890	COG0741	lytic transglycosylase activity
K6748_03895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6748_03900	COG2226	methyltransferase
K6748_03905	COG0328	RNA-DNA hybrid ribonuclease activity
K6748_03940	COG1960	acyl-CoA dehydrogenase activity
K6748_03945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6748_03950	COG0121	glutamine amidotransferase
K6748_03955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6748_03960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6748_03965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6748_03970	COG2233	PERMEase
K6748_03990	COG1393	Belongs to the ArsC family
K6748_03995	COG4783	chaperone-mediated protein folding
K6748_04010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6748_04020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6748_04025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6748_04040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6748_04045	COG1393	Belongs to the ArsC family
K6748_04070	COG2837	iron assimilation
K6748_04075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_04080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_04085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_04090	COG1334	flagellar protein FlaG
K6748_04095	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6748_04105	COG1516	flagellar protein fliS
K6748_04125	COG1677	Flagellar hook-basal body complex protein FliE
K6748_04135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6748_04195	COG1987	bacterial-type flagellum assembly
K6748_04200	COG1684	flagellar biosynthetic protein fliR
K6748_04235	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K6748_04240	COG0784	Response regulator, receiver
K6748_04240	COG2198	Histidine kinase
K6748_04240	COG0643	Histidine kinase
K6748_04245	COG2201	protein-glutamate methylesterase activity
K6748_04250	COG1192	Involved in chromosome partitioning
K6748_04260	COG0835	chemotaxis
K6748_04270	COG4133	protoheme IX ABC transporter activity
K6748_04275	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6748_04280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6748_04285	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6748_04290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K6748_04295	COG1138	Cytochrome C-type biogenesis protein
K6748_04300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6748_04310	COG3088	subunit of a heme lyase
K6748_04310	COG4235	cytochrome complex assembly
K6748_04320	COG2067	long-chain fatty acid transport protein
K6748_04340	COG0183	Belongs to the thiolase family
K6748_04345	COG1024	Enoyl-CoA hydratase
K6748_04345	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6748_04360	COG2062	phosphohistidine phosphatase, SixA
K6748_04365	COG2840	Smr protein MutS2
K6748_04370	COG2890	protein-(glutamine-N5) methyltransferase activity
K6748_04375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6748_04380	COG2860	membrane
K6748_04385	COG3101	peptidyl-lysine hydroxylation
K6748_04395	COG0431	NADPH-dependent FMN reductase
K6748_04400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6748_04400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6748_04405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6748_04410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6748_04415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6748_04425	COG0101	tRNA pseudouridine synthase activity
K6748_04430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6748_04435	COG0285	dihydrofolate synthase activity
K6748_04440	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6748_04445	COG1286	toxin biosynthetic process
K6748_04450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6748_04455	COG0583	DNA-binding transcription factor activity
K6748_04460	COG0745	RESPONSE REGULATOR receiver
K6748_04465	COG2832	Protein of unknown function (DUF454)
K6748_04470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6748_04485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6748_04490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6748_04500	COG2261	transglycosylase associated protein
K6748_04505	COG2983	Belongs to the UPF0260 family
K6748_04510	COG0668	transmembrane transport
K6748_04515	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6748_04520	COG0346	lactoylglutathione lyase activity
K6748_04530	COG1785	Belongs to the alkaline phosphatase family
K6748_04545	COG2226	methyltransferase
K6748_04560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6748_04565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6748_04575	COG3139	Protein of unknown function (DUF1315)
K6748_04580	COG0252	asparaginase activity
K6748_04585	COG0616	signal peptide processing
K6748_04590	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6748_04590	COG1902	pentaerythritol trinitrate reductase activity
K6748_04600	COG0778	Nitroreductase
K6748_04605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6748_04620	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6748_04635	COG3082	Protein of unknown function (DUF1414)
K6748_04640	COG3081	Nucleoid-associated protein
K6748_04655	COG1757	Na H antiporter
K6748_04660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6748_04665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6748_04670	COG2095	MarC family integral membrane protein
K6748_04675	COG1454	alcohol dehydrogenase
K6748_04675	COG1012	belongs to the aldehyde dehydrogenase family
K6748_04695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6748_04705	COG2056	Na+-H+ antiporter family
K6748_04710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6748_04715	COG2885	chlorophyll binding
K6748_04725	COG0346	lactoylglutathione lyase activity
K6748_04730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6748_04735	COG4660	Part of a membrane complex involved in electron transport
K6748_04740	COG4659	FMN binding
K6748_04745	COG4658	electron transport chain
K6748_04750	COG4656	Part of a membrane complex involved in electron transport
K6748_04755	COG2878	Part of a membrane complex involved in electron transport
K6748_04760	COG4657	Part of a membrane complex involved in electron transport
K6748_04765	COG1882	Formate acetyltransferase
K6748_04775	COG0556	nucleotide-excision repair
K6748_04780	COG2204	response regulator
K6748_04785	COG2198	Histidine kinase
K6748_04790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6748_04795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6748_04800	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6748_04805	COG0315	cyclic pyranopterin monophosphate synthase activity
K6748_04810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6748_04815	COG0314	molybdopterin synthase activity
K6748_04825	COG0601	transmembrane transport
K6748_04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6748_04835	COG0444	Belongs to the ABC transporter superfamily
K6748_04845	COG0435	Glutathione S-transferase
K6748_04855	COG0280	phosphate acetyltransferase
K6748_04855	COG0857	belongs to the CobB CobQ family
K6748_04860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6748_04865	COG3092	negative regulation of chromosome organization
K6748_04875	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6748_04880	COG1122	ATPase activity
K6748_04885	COG0366	Alpha amylase catalytic
K6748_04890	COG3706	GGDEF domain
K6748_04895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6748_04900	COG3012	SEC-C Motif Domain Protein
K6748_04900	COG3318	Belongs to the UPF0149 family
K6748_04905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6748_04910	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6748_04915	COG2186	Transcriptional regulator
K6748_04925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6748_04925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6748_04935	COG0572	uridine kinase
K6748_04945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6748_04950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6748_04955	COG0659	secondary active sulfate transmembrane transporter activity
K6748_04960	COG1530	ribonuclease E activity
K6748_04965	COG0564	pseudouridine synthase activity
K6748_04970	COG0424	maF-like protein
K6748_04975	COG1399	metal-binding, possibly nucleic acid-binding protein
K6748_04985	COG0416	fatty acid biosynthetic process
K6748_04990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6748_05020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6748_05025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6748_05030	COG0470	DNA polymerase III
K6748_05035	COG0084	hydrolase, TatD family'
K6748_05040	COG1263	PTS System
K6748_05040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6748_05055	COG0733	neurotransmitter:sodium symporter activity
K6748_05070	COG4667	esterase of the alpha-beta hydrolase superfamily
K6748_05075	COG0469	pyruvate kinase activity
K6748_05080	COG1940	carbohydrate kinase activity
K6748_05085	COG0784	Response regulator, receiver
K6748_05085	COG0835	chemotaxis
K6748_05090	COG0587	DNA-directed DNA polymerase activity
K6748_05105	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_05110	COG0616	signal peptide processing
K6748_05115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6748_05120	COG0539	negative regulation of cytoplasmic translation
K6748_05130	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6748_05135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6748_05145	COG4166	transmembrane transport
K6748_05165	COG3008	intermembrane lipid transfer
K6748_05165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6748_05170	COG2995	paraquat-inducible protein a
K6748_05175	COG3258	Cytochrome c
K6748_05180	COG2863	cytochrome
K6748_05215	COG4232	protein-disulfide reductase activity
K6748_05220	COG3118	belongs to the thioredoxin family
K6748_05245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6748_05255	COG0577	efflux transmembrane transporter activity
K6748_05255	COG1136	(ABC) transporter
K6748_05265	COG0577	efflux transmembrane transporter activity
K6748_05265	COG1136	(ABC) transporter
K6748_05315	COG3850	Histidine kinase
K6748_05315	COG5002	protein histidine kinase activity
K6748_05320	COG0745	RESPONSE REGULATOR receiver
K6748_05325	COG0463	Glycosyl transferase, family 2
K6748_05330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6748_05350	COG1032	radical SAM domain protein
K6748_05355	COG5001	Diguanylate cyclase
K6748_05370	COG0583	DNA-binding transcription factor activity
K6748_05375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6748_05385	COG2350	Protein conserved in bacteria
K6748_05395	COG2917	probably involved in intracellular septation
K6748_05415	COG1301	dicarboxylic acid transport
K6748_05420	COG0318	PFAM AMP-dependent synthetase and ligase
K6748_05425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6748_05430	COG0159	tryptophan synthase activity
K6748_05440	COG0135	phosphoribosylanthranilate isomerase activity
K6748_05440	COG0134	indole-3-glycerol-phosphate synthase activity
K6748_05450	COG0512	Glutamine amidotransferase of anthranilate synthase
K6748_05455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6748_05465	COG0613	PHP domain protein
K6748_05470	COG0009	L-threonylcarbamoyladenylate synthase
K6748_05480	COG1187	pseudouridine synthase activity
K6748_05500	COG0417	DNA replication proofreading
K6748_05505	COG2197	response regulator
K6748_05510	COG0322	excinuclease ABC activity
K6748_05550	COG0019	diaminopimelate decarboxylase activity
K6748_05580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6748_05585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6748_05605	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6748_05615	COG0437	4 iron, 4 sulfur cluster binding
K6748_05620	COG3301	Polysulphide reductase, NrfD
K6748_05625	COG1138	Cytochrome C-type biogenesis protein
K6748_05635	COG4235	cytochrome complex assembly
K6748_05635	COG3088	subunit of a heme lyase
K6748_05645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6748_05670	COG2989	Protein conserved in bacteria
K6748_05675	COG3108	Peptidase M15
K6748_05680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6748_05695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6748_05725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6748_05730	COG0840	transmembrane signaling receptor activity
K6748_05750	COG1448	Aminotransferase
K6748_05765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6748_05775	COG0017	Asparaginyl-tRNA synthetase
K6748_05780	COG0840	transmembrane signaling receptor activity
K6748_05785	COG3300	MHYT domain
K6748_05785	COG5001	Diguanylate cyclase
K6748_05800	COG0720	synthase
K6748_05810	COG2200	EAL domain
K6748_05815	COG1760	l-serine dehydratase
K6748_05820	COG0814	amino acid
K6748_05825	COG0494	nUDIX hydrolase
K6748_05835	COG0784	Response regulator, receiver
K6748_05835	COG2205	protein histidine kinase activity
K6748_05840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6748_05855	COG3106	COG3106 Predicted ATPase
K6748_05860	COG3768	UPF0283 membrane protein
K6748_05870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6748_05990	COG0653	protein targeting
K6748_06120	COG0791	NLP P60 protein
K6748_06215	COG2314	TM2 domain
K6748_06230	COG0454	-acetyltransferase
K6748_06365	COG3313	Fe-S protein
K6748_06565	COG0110	maltose O-acetyltransferase activity
K6748_06570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6748_06575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6748_06595	COG5507	3-demethylubiquinone-9 3-methyltransferase
K6748_06600	COG1280	lysine exporter protein (LysE YggA)
K6748_06605	COG1280	lysine exporter protein (LysE YggA)
K6748_06615	COG0729	surface antigen
K6748_06620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6748_06625	COG2272	Belongs to the type-B carboxylesterase lipase family
K6748_06650	COG2985	domain, Protein
K6748_06660	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6748_06690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6748_06705	COG3290	protein histidine kinase activity
K6748_06710	COG4565	transcriptional regulatory protein
K6748_06720	COG2207	Transcriptional regulator
K6748_06725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6748_06730	COG0363	glucosamine-6-phosphate deaminase activity
K6748_06735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6748_06755	COG3284	Transcriptional regulator
K6748_06760	COG1012	belongs to the aldehyde dehydrogenase family
K6748_06830	COG4669	(LipO)protein
K6748_06850	COG3177	Filamentation induced by cAMP protein fic
K6748_06880	COG2207	Transcriptional regulator
K6748_06885	COG4792	protein secretion
K6748_06890	COG4791	protein targeting
K6748_06895	COG4794	Type iii secretion
K6748_06900	COG4790	Type iii secretion
K6748_06970	COG0457	Tetratricopeptide repeat
K6748_06985	COG2358	TRAP transporter, solute receptor (TAXI family
K6748_06990	COG0730	response to heat
K6748_07025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6748_07030	COG0372	Belongs to the citrate synthase family
K6748_07040	COG2828	Protein conserved in bacteria
K6748_07065	COG0561	phosphatase activity
K6748_07070	COG0602	queuosine metabolic process
K6748_07075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6748_07090	COG0583	DNA-binding transcription factor activity
K6748_07095	COG0583	DNA-binding transcription factor activity
K6748_07110	COG0583	DNA-binding transcription factor activity
K6748_07125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6748_07130	COG0765	amino acid transport
K6748_07135	COG1126	abc transporter atp-binding protein
K6748_07140	COG0646	methionine synthase
K6748_07140	COG1410	methionine synthase
K6748_07160	COG1335	isochorismatase
K6748_07180	COG2814	Major facilitator Superfamily
K6748_07185	COG0583	DNA-binding transcription factor activity
K6748_07195	COG0583	DNA-binding transcription factor activity
K6748_07200	COG0656	L-ascorbic acid biosynthetic process
K6748_07210	COG1414	Transcriptional regulator
K6748_07215	COG3706	GGDEF domain
K6748_07240	COG2885	chlorophyll binding
K6748_07260	COG0840	transmembrane signaling receptor activity
K6748_07265	COG1254	Belongs to the acylphosphatase family
K6748_07270	COG2920	part of a sulfur-relay system
K6748_07280	COG0670	Belongs to the BI1 family
K6748_07285	COG1126	abc transporter atp-binding protein
K6748_07290	COG0765	amino acid transport
K6748_07295	COG4597	amino acid ABC transporter
K6748_07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6748_07310	COG1666	GTP binding
K6748_07315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6748_07340	COG3008	intermembrane lipid transfer
K6748_07345	COG2995	paraquat-inducible protein a
K6748_07350	COG1132	(ABC) transporter
K6748_07355	COG1956	GAF domain-containing protein
K6748_07360	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6748_07375	COG0308	aminopeptidase N
K6748_07385	COG2902	Dehydrogenase
K6748_07390	COG0167	dihydroorotate dehydrogenase activity
K6748_07400	COG0116	Belongs to the methyltransferase superfamily
K6748_07400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6748_07410	COG0488	(ABC) transporter
K6748_07425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6748_07430	COG1067	ATP-dependent peptidase activity
K6748_07435	COG3120	sequence-specific DNA binding
K6748_07450	COG2205	protein histidine kinase activity
K6748_07450	COG0784	Response regulator, receiver
K6748_07465	COG3278	Belongs to the heme-copper respiratory oxidase family
K6748_07480	COG2010	Cytochrome c
K6748_07490	COG2217	Heavy metal translocating P-type atpase
K6748_07505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6748_07510	COG0589	response to stress
K6748_07535	COG3842	ATPase activity
K6748_07545	COG1177	transmembrane transport
K6748_07555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6748_07560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6748_07570	COG0004	ammonium transporteR
K6748_07595	COG0437	4 iron, 4 sulfur cluster binding
K6748_07600	COG0243	molybdopterin cofactor binding
K6748_07600	COG3383	formate dehydrogenase (NAD+) activity
K6748_07610	COG3381	protein complex oligomerization
K6748_07630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6748_07635	COG0488	(ABC) transporter
K6748_07640	COG4191	Histidine kinase
K6748_07645	COG2204	response regulator
K6748_07660	COG3842	ATPase activity
K6748_07665	COG0746	molybdenum cofactor guanylyltransferase activity
K6748_07670	COG0303	'Molybdopterin
K6748_07680	COG1940	carbohydrate kinase activity
K6748_07685	COG3148	PFAM DTW domain containing protein
K6748_07715	COG0791	NLP P60 protein
K6748_07725	COG3706	GGDEF domain
K6748_07735	COG3001	Fructosamine kinase
K6748_07745	COG0307	riboflavin synthase, alpha
K6748_07750	COG0534	Mate efflux family protein
K6748_07760	COG1793	dna ligase
K6748_07790	COG2204	response regulator
K6748_07795	COG0297	glycogen (starch) synthase activity
K6748_07800	COG0438	transferase activity, transferring glycosyl groups
K6748_07830	COG0438	transferase activity, transferring glycosyl groups
K6748_07835	COG1215	transferase activity, transferring glycosyl groups
K6748_07840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6748_07850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6748_07865	COG1643	Atp-dependent helicase
K6748_07870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6748_07915	COG0443	Heat shock 70 kDa protein
K6748_07920	COG0443	Heat shock 70 kDa protein
K6748_07940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6748_07945	COG0583	DNA-binding transcription factor activity
K6748_07965	COG1132	(ABC) transporter
K6748_07970	COG1132	(ABC) transporter
K6748_07980	COG4774	siderophore transport
K6748_07990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6748_07995	COG1120	ATPase activity
K6748_08010	COG0814	amino acid
K6748_08020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6748_08030	COG0861	Integral membrane protein TerC family
K6748_08040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6748_08045	COG1328	CTP reductase activity
K6748_08060	COG5001	Diguanylate cyclase
K6748_08060	COG3300	MHYT domain
K6748_08075	COG0471	metal ion transport
K6748_08100	COG4702	Belongs to the UPF0303 family
K6748_08105	COG0673	inositol 2-dehydrogenase activity
K6748_08110	COG1349	DNA-binding transcription factor activity
K6748_08125	COG1538	Outer membrane efflux protein
K6748_08165	COG0641	radical SAM
K6748_08180	COG3119	arylsulfatase activity
K6748_08185	COG0527	aspartate kinase activity
K6748_08190	COG0662	Cupin 2, conserved barrel domain protein
K6748_08195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6748_08200	COG0456	acetyltransferase
K6748_08205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6748_08220	COG4175	Glycine betaine
K6748_08225	COG4176	ABC-type proline glycine betaine transport system permease component
K6748_08230	COG2113	Glycine betaine
K6748_08235	COG1368	sulfuric ester hydrolase activity
K6748_08260	COG1115	amino acid carrier protein
K6748_08270	COG1280	lysine exporter protein (LysE YggA)
K6748_08275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6748_08280	COG1560	Kdo2-lipid A biosynthetic process
K6748_08295	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6748_08300	COG3063	Type IV pilus biogenesis stability protein PilW
K6748_08340	COG2315	Protein conserved in bacteria
K6748_08345	COG1846	Transcriptional regulator
K6748_08355	COG2200	EAL domain
K6748_08360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6748_08365	COG1012	belongs to the aldehyde dehydrogenase family
K6748_08370	COG2957	Belongs to the agmatine deiminase family
K6748_08380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6748_08385	COG1012	belongs to the aldehyde dehydrogenase family
K6748_08390	COG1396	sequence-specific DNA binding
K6748_08390	COG1917	Cupin 2, conserved barrel domain protein
K6748_08395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6748_08400	COG0174	glutamine synthetase
K6748_08405	COG1757	Na H antiporter
K6748_08420	COG1742	UPF0060 membrane protein
K6748_08445	COG3755	Protein conserved in bacteria
K6748_08490	COG0625	glutathione transferase activity
K6748_08500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K6748_08510	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6748_08520	COG0601	transmembrane transport
K6748_08525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6748_08545	COG3291	Pkd domain containing protein
K6748_08555	COG1177	transmembrane transport
K6748_08560	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6748_08565	COG3842	ATPase activity
K6748_08570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6748_08575	COG2423	ornithine cyclodeaminase activity
K6748_08590	COG3938	Belongs to the proline racemase family
K6748_08625	COG1451	nucleotide metabolic process
K6748_08635	COG0583	DNA-binding transcription factor activity
K6748_08655	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K6748_08660	COG4139	cobalamin transport
K6748_08665	COG2988	succinylglutamate desuccinylase activity
K6748_08685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6748_08690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6748_08695	COG0702	epimerase
K6748_08700	COG1823	symporter activity
K6748_08845	COG1484	DNA-dependent DNA replication
K6748_08865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6748_08905	COG2925	Exonuclease
K6748_08910	COG1380	Effector of murein hydrolase LrgA
K6748_08915	COG1346	cytolysis
K6748_08920	COG0295	cytidine deaminase activity
K6748_08925	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6748_08930	COG0500	methyltransferase
K6748_08940	COG0776	regulation of translation
K6748_08950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6748_08950	COG0072	phenylalanine-tRNA ligase activity
K6748_08955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6748_08990	COG0393	Putative heavy-metal-binding
K6748_09000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6748_09010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6748_09025	COG2188	Transcriptional regulator
K6748_09030	COG1228	amidohydrolase
K6748_09035	COG0010	Belongs to the arginase family
K6748_09040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6748_09045	COG2986	histidine ammonia-lyase
K6748_09060	COG0247	lactate metabolic process
K6748_09060	COG0277	FAD linked oxidase domain protein
K6748_09095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6748_09110	COG1643	Atp-dependent helicase
K6748_09115	COG0281	malic enzyme
K6748_09120	COG2949	membrane
K6748_09125	COG0471	metal ion transport
K6748_09150	COG0492	ferredoxin-NADP+ reductase activity
K6748_09155	COG4988	ABC transporter
K6748_09160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6748_09170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6748_09180	COG4191	Histidine kinase
K6748_09180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6748_09195	COG3070	regulator of competence-specific genes
K6748_09205	COG2431	L-lysine efflux transmembrane transporter activity
K6748_09215	COG0076	glutamate decarboxylase activity
K6748_09220	COG1737	Transcriptional regulator
K6748_09230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6748_09235	COG2985	domain, Protein
K6748_09235	COG3273	potassium ion transport
K6748_09240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6748_09245	COG1960	acyl-CoA dehydrogenase activity
K6748_09255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6748_09275	COG0534	Mate efflux family protein
K6748_09280	COG0702	epimerase
K6748_09290	COG2814	Major facilitator Superfamily
K6748_09295	COG1187	pseudouridine synthase activity
K6748_09300	COG1061	Type III restriction enzyme res subunit
K6748_09320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6748_09340	COG3313	Fe-S protein
K6748_09350	COG4134	Bacterial extracellular solute-binding protein
K6748_09355	COG4135	transport system, permease component
K6748_09360	COG4136	ATPase activity
K6748_09365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6748_09375	COG3604	Transcriptional regulator
K6748_09380	COG1151	hydroxylamine reductase activity
K6748_09385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6748_09395	COG0564	pseudouridine synthase activity
K6748_09400	COG0733	neurotransmitter:sodium symporter activity
K6748_09410	COG0626	cystathionine gamma-synthase activity
K6748_09415	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6748_09420	COG5380	lipid catabolic process
K6748_09425	COG2818	Glycosylase
K6748_09445	COG1983	PspC domain protein
K6748_09455	COG1842	Phage shock protein A
K6748_09460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6748_09475	COG4171	peptide transport system, permease
K6748_09485	COG4172	Belongs to the ABC transporter superfamily
K6748_09495	COG1227	inorganic diphosphatase activity
K6748_09510	COG0243	molybdopterin cofactor binding
K6748_09515	COG3005	denitrification pathway
K6748_09520	COG4459	periplasmic nitrate reductase
K6748_09525	COG0390	transport system, permease component
K6748_09535	COG2116	formate transmembrane transporter activity
K6748_09560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6748_09565	COG1435	thymidine kinase activity
K6748_09570	COG0215	cysteine-tRNA ligase activity
K6748_09575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6748_09580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6748_09585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6748_09590	COG3012	SEC-C Motif Domain Protein
K6748_09595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6748_09595	COG0140	phosphoribosyl-ATP diphosphatase activity
K6748_09605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6748_09610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6748_09615	COG0131	Imidazoleglycerol-phosphate dehydratase
K6748_09615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6748_09625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6748_09635	COG1757	Na H antiporter
K6748_09645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6748_09660	COG2915	High frequency lysogenization protein hflD homolog
K6748_09665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6748_09675	COG2268	Band 7 protein
K6748_09685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6748_09700	COG0300	oxidoreductase activity
K6748_09720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6748_09745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6748_09765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6748_09775	COG1674	ftsk spoiiie
K6748_09785	COG0686	Belongs to the AlaDH PNT family
K6748_09795	COG0583	DNA-binding transcription factor activity
K6748_09820	COG3568	Endonuclease Exonuclease Phosphatase
K6748_09845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6748_09850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6748_09870	COG1271	oxidase subunit
K6748_09875	COG1294	oxidase, subunit
K6748_09890	COG0784	Response regulator, receiver
K6748_09890	COG5002	protein histidine kinase activity
K6748_09900	COG0754	glutathionylspermidine amidase activity
K6748_09910	COG3766	membrane
K6748_09920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6748_09925	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K6748_09930	COG2885	chlorophyll binding
K6748_09935	COG0823	Involved in the tonB-independent uptake of proteins
K6748_09950	COG0811	peptide transport
K6748_09955	COG0824	Thioesterase
K6748_09965	COG4890	Cyd operon protein YbgT
K6748_09970	COG1294	oxidase, subunit
K6748_09975	COG1271	oxidase subunit
K6748_09980	COG2255	four-way junction helicase activity
K6748_09985	COG0632	four-way junction helicase activity
K6748_09990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6748_09995	COG0217	transcriptional regulatory protein
K6748_10005	COG1801	Protein of unknown function DUF72
K6748_10015	COG0500	methyltransferase
K6748_10020	COG0189	ligase activity
K6748_10020	COG4067	protein conserved in archaea
K6748_10040	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6748_10045	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6748_10050	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K6748_10055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6748_10060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6748_10065	COG0745	RESPONSE REGULATOR receiver
K6748_10070	COG3381	protein complex oligomerization
K6748_10075	COG1609	Transcriptional regulator
K6748_10080	COG3070	regulator of competence-specific genes
K6748_10100	COG0297	glycogen (starch) synthase activity
K6748_10105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6748_10110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6748_10130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6748_10135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K6748_10140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6748_10145	COG0542	response to heat
K6748_10150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6748_10155	COG1278	Cold shock
K6748_10165	COG1187	pseudouridine synthase activity
K6748_10170	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6748_10175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6748_10180	COG1199	ATP-dependent helicase activity
K6748_10185	COG0730	response to heat
K6748_10190	COG3923	Primosomal replication protein n
K6748_10200	COG0708	Exodeoxyribonuclease III
K6748_10240	COG1882	Formate acetyltransferase
K6748_10250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6748_10260	COG3013	Belongs to the UPF0304 family
K6748_10265	COG2766	serine protein kinase
K6748_10270	COG2718	Belongs to the UPF0229 family
K6748_10275	COG2719	SpoVR family
K6748_10295	COG1132	(ABC) transporter
K6748_10300	COG2333	competence protein COMEC
K6748_10300	COG0658	competence protein
K6748_10310	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6748_10315	COG1136	(ABC) transporter
K6748_10320	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6748_10330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6748_10345	COG1252	NADH dehydrogenase
K6748_10350	COG3150	esterase
K6748_10375	COG0537	adenosine 5'-monophosphoramidase activity
K6748_10400	COG0517	IMP dehydrogenase activity
K6748_10400	COG0516	GMP reductase activity
K6748_10405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6748_10430	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K6748_10435	COG1946	Acyl-CoA thioesterase
K6748_10445	COG1522	sequence-specific DNA binding
K6748_10450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6748_10465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6748_10470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6748_10515	COG0477	Major facilitator Superfamily
K6748_10520	COG2855	membrane
K6748_10540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6748_10550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6748_10555	COG1169	isochorismate synthase
K6748_10560	COG0436	Aminotransferase
K6748_10565	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6748_10570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6748_10585	COG1555	photosystem II stabilization
K6748_10590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6748_10595	COG0776	regulation of translation
K6748_10600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6748_10605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6748_10615	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6748_10630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6748_10635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6748_10640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6748_10645	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6748_10660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6748_10665	COG0569	domain protein
K6748_10670	COG0513	Belongs to the DEAD box helicase family
K6748_10705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6748_10710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6748_10725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6748_10730	COG1216	Glycosyl transferase, family 2
K6748_10735	COG2986	histidine ammonia-lyase
K6748_10760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6748_10770	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_10780	COG2226	methyltransferase
K6748_10790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6748_10795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6748_10805	COG2951	lytic endotransglycosylase activity
K6748_10810	COG3100	YcgL domain-containing protein
K6748_10815	COG0850	regulation of cytokinetic process
K6748_10820	COG2894	cell division
K6748_10825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6748_10830	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6748_10835	COG0318	PFAM AMP-dependent synthetase and ligase
K6748_10840	COG2267	carboxylic ester hydrolase activity
K6748_10845	COG3065	identical protein binding
K6748_10855	COG1214	PFAM Peptidase M22, glycoprotease
K6748_10860	COG1199	ATP-dependent helicase activity
K6748_10865	COG0788	formyltetrahydrofolate deformylase activity
K6748_10870	COG3102	Protein conserved in bacteria
K6748_10875	COG0018	arginyl-trna synthetase
K6748_10900	COG1918	ferrous iron import across plasma membrane
K6748_10910	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K6748_10915	COG1121	(ABC) transporter
K6748_10920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6748_10930	COG0045	succinate-CoA ligase (ADP-forming) activity
K6748_10935	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6748_10940	COG0567	Dehydrogenase, E1 component
K6748_10945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6748_10950	COG1053	succinate dehydrogenase
K6748_10955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6748_10970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6748_10980	COG0033	Phosphoglucomutase
K6748_10985	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6748_10990	COG0596	Alpha beta hydrolase
K6748_11000	COG0716	FMN binding
K6748_11010	COG0735	belongs to the Fur family
K6748_11015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6748_11020	COG2190	(PTS) system
K6748_11020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6748_11020	COG1263	PTS System
K6748_11025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6748_11030	COG1846	Transcriptional regulator
K6748_11030	COG1940	carbohydrate kinase activity
K6748_11035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6748_11035	COG4651	solute:proton antiporter activity
K6748_11040	COG0367	asparagine synthase
K6748_11045	COG0250	Participates in transcription elongation, termination and antitermination
K6748_11050	COG3104	oligopeptide transport
K6748_11055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6748_11065	COG0326	Molecular chaperone. Has ATPase activity
K6748_11070	COG3710	Transcriptional regulator
K6748_11090	COG0622	Phosphoesterase
K6748_11115	COG1090	epimerase
K6748_11120	COG0300	oxidoreductase activity
K6748_11125	COG3118	belongs to the thioredoxin family
K6748_11130	COG0457	Tetratricopeptide repeat
K6748_11130	COG3118	belongs to the thioredoxin family
K6748_11135	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6748_11145	COG1215	transferase activity, transferring glycosyl groups
K6748_11150	COG1192	Involved in chromosome partitioning
K6748_11170	COG2194	sulfuric ester hydrolase activity
K6748_11175	COG0330	HflC and HflK could
K6748_11190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6748_11195	COG3115	cell septum assembly
K6748_11200	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6748_11205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6748_11210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6748_11215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6748_11220	COG2190	(PTS) system
K6748_11225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_11230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_11235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_11240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_11250	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6748_11250	COG3951	Flagellar rod assembly protein muramidase FlgJ
K6748_11255	COG1706	bacterial-type flagellum-dependent cell motility
K6748_11260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6748_11270	COG4787	bacterial-type flagellum-dependent cell motility
K6748_11275	COG1749	Flagellar hook protein flgE
K6748_11285	COG1558	bacterial-type flagellum-dependent cell motility
K6748_11290	COG1815	bacterial-type flagellum-dependent cell motility
K6748_11295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6748_11300	COG0784	Response regulator, receiver
K6748_11300	COG0835	chemotaxis
K6748_11355	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6748_11365	COG2217	Heavy metal translocating P-type atpase
K6748_11365	COG2608	mercury ion transmembrane transporter activity
K6748_11405	COG2840	Smr protein MutS2
K6748_11410	COG1187	pseudouridine synthase activity
K6748_11415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6748_11420	COG0737	Belongs to the 5'-nucleotidase family
K6748_11425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6748_11430	COG2912	Transglutaminase-like superfamily
K6748_11435	COG3094	Invasion gene expression up-regulator, SirB
K6748_11440	COG2890	protein-(glutamine-N5) methyltransferase activity
K6748_11450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6748_11455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6748_11460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6748_11465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6748_11470	COG0193	aminoacyl-tRNA hydrolase activity
K6748_11475	COG0012	GTP binding
K6748_11580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6748_11585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6748_11590	COG1702	phosphate starvation-inducible protein PhoH
K6748_11595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6748_11600	COG4535	Mg2 and Co2 transporter CorC
K6748_11605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6748_11610	COG2888	peptidyl-tyrosine sulfation
K6748_11615	COG0495	leucyl-tRNA aminoacylation
K6748_11620	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6748_11625	COG1466	dna polymerase III delta subunit
K6748_11630	COG0799	negative regulation of ribosome biogenesis
K6748_11635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6748_11640	COG0768	penicillin binding
K6748_11645	COG0772	Belongs to the SEDS family
K6748_11650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6748_11655	COG1686	Belongs to the peptidase S11 family
K6748_11665	COG0321	lipoyl(octanoyl) transferase activity
K6748_11670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6748_11675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6748_11680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6748_11695	COG0366	Alpha amylase catalytic
K6748_11700	COG1263	PTS System
K6748_11700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6748_11710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6748_11715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6748_11720	COG2011	ABC-type metal ion transport system permease component
K6748_11725	COG1464	Belongs to the NlpA lipoprotein family
K6748_11730	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K6748_11740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6748_11740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6748_11755	COG1611	Belongs to the LOG family
K6748_11760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6748_11770	COG2363	Small membrane protein
K6748_11780	COG0583	DNA-binding transcription factor activity
K6748_11785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6748_11785	COG0301	tRNA thio-modification
K6748_11795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6748_11800	COG1722	exodeoxyribonuclease VII activity
K6748_11805	COG0142	geranyltranstransferase activity
K6748_11810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6748_11815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6748_11820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6748_11830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6748_11845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6748_11845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6748_11850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6748_11855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6748_11860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6748_11870	COG1073	alpha beta
K6748_11875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6748_11880	COG2252	PERMEase
K6748_11885	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6748_11915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6748_11915	COG0047	phosphoribosylformylglycinamidine synthase activity
K6748_11920	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6748_11930	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6748_11960	COG0484	heat shock protein binding
K6748_11970	COG1301	dicarboxylic acid transport
K6748_11975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6748_11980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6748_11990	COG0497	DNA recombination
K6748_12000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6748_12005	COG2914	Belongs to the UPF0125 (RnfH) family
K6748_12010	COG2867	negative regulation of translational initiation
K6748_12015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6748_12025	COG0582	viral genome integration into host DNA
K6748_12030	COG0210	DNA helicase
K6748_12065	COG3311	Transcriptional regulator
K6748_12090	COG0583	DNA-binding transcription factor activity
K6748_12095	COG3153	acetyltransferase
K6748_12095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6748_12115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6748_12120	COG2873	o-acetylhomoserine
K6748_12135	COG1115	amino acid carrier protein
K6748_12140	COG1584	GPR1 FUN34 yaaH family protein
K6748_12150	COG1757	Na H antiporter
K6748_12155	COG0519	Catalyzes the synthesis of GMP from XMP
K6748_12155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6748_12160	COG0516	GMP reductase activity
K6748_12160	COG0517	IMP dehydrogenase activity
K6748_12180	COG1160	GTP binding
K6748_12185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6748_12190	COG2976	Protein conserved in bacteria
K6748_12195	COG0124	histidyl-tRNA synthetase
K6748_12200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6748_12215	COG0105	UTP biosynthetic process
K6748_12225	COG2975	iron-sulfur cluster assembly
K6748_12230	COG0633	Ferredoxin
K6748_12235	COG0443	Heat shock 70 kDa protein
K6748_12250	COG0822	iron-sulfur transferase activity
K6748_12255	COG1104	cysteine desulfurase activity
K6748_12265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K6748_12270	COG0483	inositol monophosphate 1-phosphatase activity
K6748_12275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6748_12280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6748_12285	COG1862	Preprotein translocase
K6748_12295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6748_12305	COG0517	IMP dehydrogenase activity
K6748_12315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6748_12320	COG0583	DNA-binding transcription factor activity
K6748_12325	COG0450	alkyl hydroperoxide reductase
K6748_12330	COG3142	Participates in the control of copper homeostasis
K6748_12340	COG0704	Plays a role in the regulation of phosphate uptake
K6748_12345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6748_12350	COG0581	inorganic phosphate transmembrane transporter activity
K6748_12355	COG0573	inorganic phosphate transmembrane transporter activity
K6748_12360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6748_12365	COG0248	Ppx GppA phosphatase
K6748_12375	COG5002	protein histidine kinase activity
K6748_12380	COG0745	RESPONSE REGULATOR receiver
K6748_12385	COG2974	May be involved in recombination
K6748_12390	COG0826	peptidase U32
K6748_12395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6748_12450	COG0542	response to heat
K6748_12460	COG0564	pseudouridine synthase activity
K6748_12465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6748_12475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6748_12480	COG1605	Chorismate mutase
K6748_12480	COG0077	Prephenate dehydratase
K6748_12485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K6748_12490	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6748_12500	COG0488	(ABC) transporter
K6748_12510	COG0739	heme binding
K6748_12515	COG1605	Chorismate mutase
K6748_12515	COG0287	Prephenate dehydrogenase
K6748_12520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6748_12525	COG1472	Belongs to the glycosyl hydrolase 3 family
K6748_12530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6748_12550	COG1966	Carbon starvation protein
K6748_12555	COG3275	phosphorelay sensor kinase activity
K6748_12560	COG3279	Response regulator of the LytR AlgR family
K6748_12570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6748_12575	COG1047	Peptidyl-prolyl cis-trans
K6748_12590	COG0196	riboflavin kinase activity
K6748_12595	COG0728	peptidoglycan biosynthetic process
K6748_12600	COG0268	Binds directly to 16S ribosomal RNA
K6748_12605	COG0640	Transcriptional regulator
K6748_12610	COG0583	DNA-binding transcription factor activity
K6748_12615	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6748_12625	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6748_12630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6748_12635	COG0730	response to heat
K6748_12660	COG0667	Aldo Keto reductase
K6748_12670	COG2204	response regulator
K6748_12685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6748_12690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6748_12695	COG4974	Belongs to the 'phage' integrase family
K6748_12700	COG0716	FMN binding
K6748_12710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6748_12715	COG0513	Belongs to the DEAD box helicase family
K6748_12720	COG3022	response to hydroperoxide
K6748_12725	COG1115	amino acid carrier protein
K6748_12740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6748_12745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6748_12750	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6748_12755	COG0431	NADPH-dependent FMN reductase
K6748_12760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6748_12765	COG0083	homoserine kinase activity
K6748_12785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6748_12795	COG0745	RESPONSE REGULATOR receiver
K6748_12805	COG5002	protein histidine kinase activity
K6748_12805	COG2198	Histidine kinase
K6748_12805	COG0784	Response regulator, receiver
K6748_12810	COG2203	Gaf domain
K6748_12810	COG3706	GGDEF domain
K6748_12810	COG4251	negative regulation of phosphorylation
K6748_12810	COG5001	Diguanylate cyclase
K6748_12815	COG1242	4 iron, 4 sulfur cluster binding
K6748_12820	COG0070	glutamate synthase
K6748_12820	COG0067	glutamate synthase
K6748_12820	COG0069	glutamate synthase activity
K6748_12830	COG0067	glutamate synthase
K6748_12830	COG0069	glutamate synthase activity
K6748_12830	COG0070	glutamate synthase
K6748_12835	COG0493	'glutamate synthase
K6748_12845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6748_12860	COG2860	membrane
K6748_12865	COG0583	DNA-binding transcription factor activity
K6748_12870	COG0730	response to heat
K6748_12885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6748_12890	COG0505	Belongs to the CarA family
K6748_12900	COG0494	nUDIX hydrolase
K6748_12905	COG0653	protein targeting
K6748_12915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6748_12920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6748_12925	COG0849	cell division
K6748_12930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6748_12945	COG0772	Belongs to the SEDS family
K6748_12950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6748_12955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6748_12960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6748_12965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6748_12970	COG0768	penicillin binding
K6748_12975	COG3116	cell division
K6748_12990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6748_13005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6748_13010	COG2823	Periplasmic or secreted lipoprotein
K6748_13015	COG2969	positive regulation of protein catabolic process
K6748_13020	COG0625	glutathione transferase activity
K6748_13025	COG2857	Cytochrome c1
K6748_13030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6748_13035	COG0723	plastoquinol--plastocyanin reductase activity
K6748_13040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6748_13050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6748_13055	COG3105	Protein conserved in bacteria
K6748_13065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6748_13070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6748_13080	COG3150	esterase
K6748_13090	COG3151	Protein conserved in bacteria
K6748_13095	COG0494	nUDIX hydrolase
K6748_13100	COG1538	Outer membrane efflux protein
K6748_13105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6748_13105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6748_13110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6748_13125	COG3025	triphosphatase activity
K6748_13130	COG1392	Phosphate transport regulator
K6748_13135	COG0306	phosphate transporter
K6748_13140	COG4991	sh3 domain protein
K6748_13145	COG0405	Gamma-glutamyltransferase
K6748_13155	COG3267	Type II secretory pathway component ExeA
K6748_13155	COG3409	Peptidoglycan-binding domain 1 protein
K6748_13165	COG1968	undecaprenyl-diphosphatase activity
K6748_13170	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6748_13175	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6748_13180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6748_13185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6748_13190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6748_13195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6748_13200	COG1610	YqeY-like protein
K6748_13205	COG0358	DNA primase activity
K6748_13240	COG2213	PTS system mannitol-specific
K6748_13240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6748_13250	COG3722	fumarate hydratase activity
K6748_13265	COG1461	Dihydroxyacetone kinase
K6748_13270	COG2376	Dihydroxyacetone kinase
K6748_13280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6748_13285	COG1349	DNA-binding transcription factor activity
K6748_13290	COG0469	pyruvate kinase activity
K6748_13305	COG0440	acetolactate synthase activity
K6748_13310	COG0028	Belongs to the TPP enzyme family
K6748_13315	COG1022	Amp-dependent synthetase and ligase
K6748_13320	COG0583	DNA-binding transcription factor activity
K6748_13340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6748_13345	COG0473	3-isopropylmalate dehydrogenase activity
K6748_13365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6748_13370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6748_13375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6748_13380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6748_13385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6748_13390	COG2967	ApaG domain
K6748_13395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6748_13400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6748_13410	COG2966	Psort location CytoplasmicMembrane, score
K6748_13415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6748_13425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6748_13430	COG0142	geranyltranstransferase activity
K6748_13450	COG2358	TRAP transporter, solute receptor (TAXI family
K6748_13465	COG1902	pentaerythritol trinitrate reductase activity
K6748_13470	COG0583	DNA-binding transcription factor activity
K6748_13475	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6748_13480	COG1178	ABC-type Fe3 transport system permease component
K6748_13490	COG0163	prenyltransferase activity
K6748_13495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6748_13500	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K6748_13505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6748_13515	COG2105	PFAM AIG2 family protein
K6748_13520	COG2911	Protein conserved in bacteria
K6748_13525	COG0729	surface antigen
K6748_13530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6748_13540	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6748_13555	COG4181	ATPase activity
K6748_13575	COG0529	Catalyzes the synthesis of activated sulfate
K6748_13580	COG0471	metal ion transport
K6748_13580	COG3273	potassium ion transport
K6748_13585	COG2895	sulfate adenylyltransferase (ATP) activity
K6748_13590	COG0175	sulfate reduction
K6748_13595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6748_13595	COG1648	precorrin-2 dehydrogenase activity
K6748_13610	COG0513	Belongs to the DEAD box helicase family
K6748_13615	COG2153	protein acetylation
K6748_13625	COG0545	Peptidyl-prolyl cis-trans isomerase
K6748_13635	COG0203	ribosomal protein L17
K6748_13640	COG0202	RNA polymerase activity
K6748_13650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6748_13655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6748_13660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6748_13665	COG0201	protein transport
K6748_13670	COG0200	Binds to the 23S rRNA
K6748_13675	COG1841	ribosomal large subunit assembly
K6748_13690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6748_13695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6748_13705	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6748_13710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6748_13720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6748_13725	COG0255	Belongs to the universal ribosomal protein uL29 family
K6748_13735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6748_13740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6748_13745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6748_13750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6748_13760	COG0088	Forms part of the polypeptide exit tunnel
K6748_13765	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6748_13775	COG0254	rRNA binding
K6748_13780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6748_13785	COG1609	Transcriptional regulator
K6748_13800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6748_13805	COG1575	Belongs to the MenA family. Type 1 subfamily
K6748_13810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6748_13820	COG1494	fructose-1,6-bisphosphatase
K6748_13850	COG0149	triose-phosphate isomerase activity
K6748_13890	COG0438	transferase activity, transferring glycosyl groups
K6748_13910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6748_13915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K6748_13920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6748_13925	COG1215	transferase activity, transferring glycosyl groups
K6748_13940	COG1216	Glycosyl transferase, family 2
K6748_13940	COG0463	Glycosyl transferase, family 2
K6748_13990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6748_14000	COG1560	Kdo2-lipid A biosynthetic process
K6748_14010	COG0859	PFAM glycosyl transferase family 9
K6748_14015	COG1519	Transferase
K6748_14020	COG0471	metal ion transport
K6748_14020	COG3273	potassium ion transport
K6748_14025	COG0175	sulfate reduction
K6748_14030	COG0529	Catalyzes the synthesis of activated sulfate
K6748_14035	COG2895	sulfate adenylyltransferase (ATP) activity
K6748_14060	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6748_14070	COG3642	lipopolysaccharide core region biosynthetic process
K6748_14075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6748_14080	COG0859	PFAM glycosyl transferase family 9
K6748_14085	COG0463	Glycosyl transferase, family 2
K6748_14100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6748_14125	COG2003	Belongs to the UPF0758 family
K6748_14135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6748_14140	COG1309	transcriptional regulator
K6748_14145	COG1560	Kdo2-lipid A biosynthetic process
K6748_14150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6748_14155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6748_14160	COG1561	YicC-like family, N-terminal region
K6748_14170	COG4608	Belongs to the ABC transporter superfamily
K6748_14175	COG0444	Belongs to the ABC transporter superfamily
K6748_14180	COG0747	negative chemotaxis
K6748_14185	COG4239	(ABC) transporter, permease
K6748_14190	COG4174	ABC transporter (Permease)
K6748_14210	COG0811	peptide transport
K6748_14215	COG0848	biopolymer transport protein
K6748_14230	COG0194	GDP metabolic process
K6748_14235	COG1758	RNA polymerase activity
K6748_14240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6748_14245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6748_14250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6748_14255	COG2233	PERMEase
K6748_14275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6748_14285	COG2183	response to ionizing radiation
K6748_14300	COG1040	competence protein
K6748_14310	COG0494	nUDIX hydrolase
K6748_14315	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6748_14325	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6748_14330	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6748_14335	COG3156	type II secretion system protein K
K6748_14340	COG4795	General secretion pathway protein
K6748_14345	COG2165	general secretion pathway protein
K6748_14350	COG2165	general secretion pathway protein
K6748_14355	COG2165	general secretion pathway protein
K6748_14360	COG1459	type II secretion system
K6748_14365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6748_14375	COG3031	protein transport across the cell outer membrane
K6748_14380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6748_14385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6748_14390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6748_14400	COG0456	acetyltransferase
K6748_14405	COG1490	D-aminoacyl-tRNA deacylase activity
K6748_14410	COG1295	ribonuclease BN
K6748_14420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6748_14425	COG1217	gtp-binding protein TYPA
K6748_14430	COG0174	glutamine synthetase
K6748_14440	COG3852	Histidine kinase
K6748_14445	COG2204	response regulator
K6748_14455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6748_14485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6748_14490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6748_14490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6748_14495	COG0456	acetyltransferase
K6748_14505	COG0084	hydrolase, TatD family'
K6748_14510	COG0805	protein transport
K6748_14515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6748_14525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6748_14530	COG3165	ubiquinone biosynthetic process from chorismate
K6748_14535	COG2226	methyltransferase
K6748_14540	COG1322	Protein conserved in bacteria
K6748_14555	COG0628	permease
K6748_14585	COG1597	lipid kinase activity
K6748_14615	COG2081	HI0933 family
K6748_14625	COG1528	Iron-storage protein
K6748_14630	COG0589	response to stress
K6748_14650	COG5002	protein histidine kinase activity
K6748_14650	COG5001	Diguanylate cyclase
K6748_14655	COG1522	sequence-specific DNA binding
K6748_14665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6748_14670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6748_14675	COG0583	DNA-binding transcription factor activity
K6748_14680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6748_14685	COG0800	Aldolase
K6748_14690	COG2610	gluconate transmembrane transporter activity
K6748_14695	COG3265	gluconokinase activity
K6748_14700	COG0129	dihydroxy-acid dehydratase activity
K6748_14715	COG0583	DNA-binding transcription factor activity
K6748_14720	COG1609	Transcriptional regulator
K6748_14760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6748_14765	COG0601	transmembrane transport
K6748_14770	COG4166	transmembrane transport
K6748_14825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6748_14830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6748_14835	COG2960	long-chain fatty acid transporting porin activity
K6748_14840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6748_14845	COG0583	DNA-binding transcription factor activity
K6748_14880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6748_14895	COG0408	coproporphyrinogen oxidase activity
K6748_14900	COG0009	L-threonylcarbamoyladenylate synthase
K6748_14905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6748_14910	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6748_14915	COG0551	DNA topoisomerase type I activity
K6748_14920	COG2922	Belongs to the Smg family
K6748_14925	COG0758	DNA mediated transformation
K6748_14935	COG0242	peptide deformylase activity
K6748_14940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6748_14945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6748_14945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6748_14950	COG0569	domain protein
K6748_14955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6748_14965	COG1272	protein, Hemolysin III
K6748_14970	COG4326	sporulation control protein
K6748_14980	COG3084	Protein conserved in bacteria
K6748_14990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6748_14995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6748_15000	COG0204	Acyl-transferase
K6748_15010	COG0606	chelatase, subunit chli
K6748_15020	COG3978	acetolactate synthase activity
K6748_15025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6748_15030	COG0129	dihydroxy-acid dehydratase activity
K6748_15040	COG0583	DNA-binding transcription factor activity
K6748_15045	COG2814	Major facilitator Superfamily
K6748_15050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6748_15055	COG0765	amino acid transport
K6748_15065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6748_15070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6748_15075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6748_15080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6748_15085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6748_15090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6748_15100	COG0356	it plays a direct role in the translocation of protons across the membrane
K6748_15105	COG3312	ion transport
K6748_15110	COG1475	DNA binding
K6748_15115	COG1192	Involved in chromosome partitioning
K6748_15120	COG0357	Ribosomal RNA small subunit methyltransferase G
K6748_15125	COG0445	tRNA wobble uridine modification
K6748_15130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6748_15140	COG0706	membrane insertase activity
K6748_15150	COG0594	ribonuclease P activity
K6748_15160	COG1126	abc transporter atp-binding protein
K6748_15190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6748_15220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6748_15225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6748_15255	COG0583	DNA-binding transcription factor activity
K6748_15265	COG4948	Mandelate Racemase Muconate Lactonizing
K6748_15295	COG1342	Belongs to the UPF0251 family
K6748_15300	COG4176	ABC-type proline glycine betaine transport system permease component
K6748_15305	COG3448	diguanylate cyclase activity
K6748_15305	COG4175	Glycine betaine
K6748_15310	COG3015	lipoprotein NlpE involved in copper resistance
K6748_15315	COG3713	MltA-interacting MipA family protein
K6748_15330	COG0583	DNA-binding transcription factor activity
K6748_15355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6748_15365	COG1335	isochorismatase
K6748_15380	COG1349	DNA-binding transcription factor activity
K6748_15390	COG2070	2-Nitropropane dioxygenase
K6748_15395	COG0531	amino acid
K6748_15400	COG4302	ethanolamine ammonia-lyase activity
K6748_15405	COG4303	Ethanolamine ammonia lyase large subunit
K6748_15415	COG1309	transcriptional regulator
K6748_15435	COG1280	lysine exporter protein (LysE YggA)
K6748_15445	COG0459	protein refolding
K6748_15450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6748_15455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6748_15470	COG1304	FMN binding
K6748_15495	COG1256	bacterial-type flagellum assembly
K6748_15495	COG4786	Flagellar basal body rod
K6748_15505	COG1706	bacterial-type flagellum-dependent cell motility
K6748_15510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6748_15515	COG4786	Flagellar basal body rod
K6748_15520	COG4787	bacterial-type flagellum-dependent cell motility
K6748_15535	COG1558	bacterial-type flagellum-dependent cell motility
K6748_15540	COG1815	bacterial-type flagellum-dependent cell motility
K6748_15560	COG0741	lytic transglycosylase activity
K6748_15565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6748_15585	COG1760	l-serine dehydratase
K6748_15600	COG0583	DNA-binding transcription factor activity
K6748_15610	COG2866	Carboxypeptidase
K6748_15615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6748_15625	COG2990	Protein conserved in bacteria
K6748_15655	COG3842	ATPase activity
K6748_15660	COG1840	ABC-type Fe3 transport system, periplasmic component
K6748_15670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6748_15680	COG1609	Transcriptional regulator
K6748_15710	COG3240	lipase activity
K6748_15715	COG1309	transcriptional regulator
K6748_15730	COG0577	efflux transmembrane transporter activity
K6748_15730	COG1136	(ABC) transporter
K6748_15735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6748_15740	COG2067	long-chain fatty acid transport protein
K6748_15750	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6748_15765	COG1011	Hydrolase
K6748_15805	COG0110	maltose O-acetyltransferase activity
K6748_15810	COG1765	OsmC-like protein
K6748_15815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6748_15815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6748_15830	COG3046	protein related to deoxyribodipyrimidine photolyase
K6748_15835	COG0415	Belongs to the DNA photolyase family
K6748_15840	COG3706	GGDEF domain
K6748_15855	COG3706	GGDEF domain
K6748_15870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6748_15885	COG3033	Beta-eliminating lyase
K6748_15895	COG1271	oxidase subunit
K6748_15900	COG1294	oxidase, subunit
K6748_15915	COG3179	chitinase
K6748_15920	COG0579	oxidoreductase
K6748_15940	COG3706	GGDEF domain
K6748_15970	COG0583	DNA-binding transcription factor activity
K6748_15990	COG0189	ligase activity
K6748_15995	COG0189	ligase activity
K6748_15995	COG4067	protein conserved in archaea
K6748_16005	COG1166	arginine decarboxylase activity
K6748_16010	COG0010	Belongs to the arginase family
K6748_16015	COG2814	Major facilitator Superfamily
K6748_16020	COG1770	oligopeptidase
K6748_16035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6748_16040	COG1121	(ABC) transporter
K6748_16045	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6748_16090	COG0848	biopolymer transport protein
K6748_16095	COG0811	peptide transport
K6748_16100	COG0811	peptide transport
K6748_16120	COG0745	RESPONSE REGULATOR receiver
K6748_16125	COG0584	glycerophosphoryl diester phosphodiesterase
K6748_16135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6748_16195	COG1901	pseudouridine methyltransferase
K6748_16200	COG0312	modulator of DNA gyrase
K6748_16205	COG0312	modulator of DNA gyrase
K6748_16210	COG0351	phosphomethylpyrimidine kinase
K6748_16215	COG1116	anion transmembrane transporter activity
K6748_16220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6748_16225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6748_16230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6748_16250	COG0243	molybdopterin cofactor binding
K6748_16255	COG3005	denitrification pathway
K6748_16260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6748_16265	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_16280	COG0456	acetyltransferase
K6748_16300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6748_16305	COG1929	Belongs to the glycerate kinase type-1 family
K6748_16310	COG2610	gluconate transmembrane transporter activity
K6748_16315	COG3835	regulator
K6748_16375	COG3047	cAMP biosynthetic process
K6748_16380	COG1357	PFAM Pentapeptide repeats (8 copies)
K6748_16410	COG2375	cellular response to nickel ion
K6748_16415	COG0583	DNA-binding transcription factor activity
K6748_16420	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6748_16425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K6748_16440	COG2199	diguanylate cyclase activity
K6748_16450	COG0561	phosphatase activity
K6748_16455	COG0583	DNA-binding transcription factor activity
K6748_16470	COG0564	pseudouridine synthase activity
K6748_16475	COG0534	Mate efflux family protein
K6748_16490	COG3123	guanosine phosphorylase activity
K6748_16505	COG0596	Alpha beta hydrolase
K6748_16530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6748_16540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6748_16545	COG2169	Transcriptional regulator
K6748_16545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6748_16555	COG2259	Doxx family
K6748_16560	COG1741	Belongs to the pirin family
K6748_16580	COG0363	glucosamine-6-phosphate deaminase activity
K6748_16590	COG0786	glutamate:sodium symporter activity
K6748_16595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6748_16600	COG1131	(ABC) transporter
K6748_16610	COG0786	glutamate:sodium symporter activity
K6748_16630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6748_16640	COG3279	Response regulator of the LytR AlgR family
K6748_16645	COG3275	phosphorelay sensor kinase activity
K6748_16675	COG0772	Belongs to the SEDS family
K6748_16700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6748_16700	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K6748_16710	COG0444	Belongs to the ABC transporter superfamily
K6748_16715	COG4608	Belongs to the ABC transporter superfamily
K6748_16740	COG1444	tRNA N-acetyltransferase activity
K6748_16760	COG3340	Belongs to the peptidase S51 family
K6748_16765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6748_16770	COG1263	PTS System
K6748_16770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6748_16775	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6748_16790	COG4166	transmembrane transport
K6748_16835	COG0259	pyridoxamine-phosphate oxidase activity
K6748_16860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6748_16895	COG1132	(ABC) transporter
K6748_16905	COG0513	Belongs to the DEAD box helicase family
K6748_16910	COG2258	MOSC domain
K6748_16955	COG3634	alkyl hydroperoxide reductase activity
K6748_16965	COG1846	Transcriptional regulator
K6748_16970	COG1764	response to oxidative stress
K6748_17005	COG0577	efflux transmembrane transporter activity
K6748_17010	COG1136	(ABC) transporter
K6748_17020	COG0826	peptidase U32
K6748_17045	COG1653	transport
K6748_17050	COG0019	diaminopimelate decarboxylase activity
K6748_17055	COG4264	IucA IucC family
K6748_17080	COG4772	TonB-dependent receptor
K6748_17085	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6748_17090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6748_17095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6748_17100	COG1120	ATPase activity
K6748_17105	COG0840	transmembrane signaling receptor activity
K6748_17110	COG0612	Peptidase, M16
K6748_17120	COG0739	heme binding
K6748_17135	COG2814	Major facilitator Superfamily
K6748_17145	COG1609	Transcriptional regulator
K6748_17150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6748_17165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6748_17165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6748_17175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6748_17180	COG1609	Transcriptional regulator
K6748_17190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6748_17230	COG1760	l-serine dehydratase
K6748_17240	COG4580	involved in the transport of maltose and maltodextrins
K6748_17255	COG0366	Alpha amylase catalytic
K6748_17260	COG2356	endonuclease I
K6748_17280	COG1982	Orn Lys Arg decarboxylase major
K6748_17285	COG0531	amino acid
K6748_17295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6748_17300	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6748_17305	COG1162	GTPase activity
K6748_17310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6748_17310	COG1263	PTS System
K6748_17315	COG1999	signal sequence binding
K6748_17330	COG2909	trisaccharide binding
K6748_17335	COG0058	SHG alpha-glucan phosphorylase activity
K6748_17340	COG1640	4-alpha-glucanotransferase
K6748_17345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6748_17350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6748_17355	COG0366	Alpha amylase catalytic
K6748_17370	COG3366	ferrous iron transmembrane transporter activity
K6748_17375	COG0700	Nucleoside recognition
K6748_17380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6748_17385	COG3339	Conserved Protein
K6748_17400	COG1301	dicarboxylic acid transport
K6748_17410	COG0583	DNA-binding transcription factor activity
K6748_17430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6748_17435	COG1596	polysaccharide export
K6748_17450	COG2095	MarC family integral membrane protein
K6748_17455	COG4667	esterase of the alpha-beta hydrolase superfamily
K6748_17460	COG3397	chitin binding
K6748_17465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K6748_17470	COG0415	Belongs to the DNA photolyase family
K6748_17480	COG1054	Belongs to the UPF0176 family
K6748_17490	COG1686	Belongs to the peptidase S11 family
K6748_17515	COG0583	DNA-binding transcription factor activity
K6748_17520	COG4628	conserved protein (DUF2132)
K6748_17540	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6748_17545	COG0628	permease
K6748_17585	COG2814	Major facilitator Superfamily
K6748_17595	COG0454	-acetyltransferase
K6748_17605	COG0745	RESPONSE REGULATOR receiver
K6748_17610	COG2205	protein histidine kinase activity
K6748_17625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6748_17630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6748_17635	COG1882	Formate acetyltransferase
K6748_17665	COG1360	Flagellar Motor Protein
K6748_17670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6748_17675	COG1191	sigma factor activity
K6748_17680	COG1580	Controls the rotational direction of flagella during chemotaxis
K6748_17695	COG1516	flagellar protein fliS
K6748_17700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6748_17710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6748_17725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6748_17735	COG1987	bacterial-type flagellum assembly
K6748_17775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6748_17835	COG0346	lactoylglutathione lyase activity
K6748_17860	COG0745	RESPONSE REGULATOR receiver
K6748_17885	COG5001	Diguanylate cyclase
K6748_17885	COG3300	MHYT domain
K6748_17890	COG0156	8-amino-7-oxononanoate synthase activity
K6748_17895	COG1063	alcohol dehydrogenase
K6748_17930	COG0668	transmembrane transport
K6748_17940	COG1304	FMN binding
K6748_17945	COG1620	l-lactate permease
K6748_17950	COG0583	DNA-binding transcription factor activity
K6748_17955	COG1505	serine-type exopeptidase activity
K6748_17960	COG4172	Belongs to the ABC transporter superfamily
K6748_17970	COG1067	ATP-dependent peptidase activity
K6748_17980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6748_18000	COG1247	-acetyltransferase
K6748_18005	COG0437	4 iron, 4 sulfur cluster binding
K6748_18010	COG0348	domain, Protein
K6748_18030	COG1122	ATPase activity
K6748_18035	COG4720	Psort location CytoplasmicMembrane, score
K6748_18040	COG1566	PFAM secretion protein HlyD family protein
K6748_18065	COG0813	purine-nucleoside phosphorylase activity
K6748_18070	COG3272	Protein of unknown function (DUF1722)
K6748_18075	COG0789	Transcriptional regulator
K6748_18080	COG0415	Belongs to the DNA photolyase family
K6748_18085	COG1388	LysM domain
K6748_18085	COG1376	ErfK ybiS ycfS ynhG family protein
K6748_18095	COG0513	Belongs to the DEAD box helicase family
K6748_18100	COG1770	oligopeptidase
K6748_18105	COG4771	TonB-dependent receptor
K6748_18135	COG0573	inorganic phosphate transmembrane transporter activity
K6748_18140	COG0581	inorganic phosphate transmembrane transporter activity
K6748_18145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6748_18160	COG2304	oxidoreductase activity
K6748_18180	COG0714	Associated with various cellular activities
K6748_18195	COG2197	response regulator
K6748_18230	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6748_18235	COG1120	ATPase activity
K6748_18240	COG4774	siderophore transport
K6748_18245	COG1132	(ABC) transporter
K6748_18250	COG2205	protein histidine kinase activity
K6748_18250	COG2205	protein histidine kinase activity
K6748_18260	COG0569	domain protein
K6748_18265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6748_18270	COG0583	DNA-binding transcription factor activity
K6748_18285	COG1012	belongs to the aldehyde dehydrogenase family
K6748_18290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6748_18295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6748_18305	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K6748_18310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6748_18340	COG2084	Dehydrogenase
K6748_18345	COG0753	catalase activity
K6748_18355	COG2130	NADP-dependent
K6748_18360	COG1309	transcriptional regulator
K6748_18405	COG0489	protein tyrosine kinase activity
K6748_18405	COG3206	protein involved in exopolysaccharide biosynthesis
K6748_18420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6748_18425	COG3842	ATPase activity
K6748_18435	COG1175	transmembrane transport
K6748_18440	COG3833	ABC-type maltose transport systems, permease component
K6748_18470	COG2354	Protein conserved in bacteria
K6748_18475	COG0418	dihydroorotase activity
K6748_18480	COG0401	homolog of Blt101
K6748_18485	COG3217	Mosc domain protein beta barrel domain protein
K6748_18485	COG0633	Ferredoxin
K6748_18485	COG0633	Ferredoxin
K6748_18485	COG3217	Mosc domain protein beta barrel domain protein
K6748_18495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6748_18535	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6748_18540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6748_18550	COG0848	biopolymer transport protein
K6748_18555	COG0811	peptide transport
K6748_18560	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6748_18570	COG3721	Heme iron utilization protein
K6748_18575	COG0748	coenzyme F420 binding
K6748_18585	COG0784	Response regulator, receiver
K6748_18585	COG0835	chemotaxis
K6748_18590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6748_18595	COG0534	Mate efflux family protein
K6748_18600	COG0444	Belongs to the ABC transporter superfamily
K6748_18605	COG4608	Belongs to the ABC transporter superfamily
K6748_18610	COG0747	negative chemotaxis
K6748_18620	COG1349	DNA-binding transcription factor activity
K6748_18625	COG2084	Dehydrogenase
K6748_18630	COG3395	kinase activity
K6748_18635	COG0235	Class ii aldolase
K6748_18640	COG3622	Belongs to the hyi family
K6748_18645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6748_18670	COG0583	DNA-binding transcription factor activity
K6748_18675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6748_18685	COG4934	collagen metabolic process
K6748_18695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6748_18700	COG0789	Transcriptional regulator
K6748_18705	COG0366	Alpha amylase catalytic
K6748_18725	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6748_18730	COG0589	response to stress
K6748_18735	COG0488	(ABC) transporter
K6748_18740	COG1505	serine-type exopeptidase activity
K6748_18750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6748_18770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6748_18795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6748_18815	COG3383	formate dehydrogenase (NAD+) activity
K6748_18825	COG0842	Transport permease protein
K6748_18830	COG1131	(ABC) transporter
K6748_18845	COG1881	PFAM PEBP family protein
K6748_18855	COG0798	PFAM Bile acid sodium symporter
K6748_18870	COG1733	regulation of RNA biosynthetic process
K6748_18895	COG4989	oxidoreductase activity
K6748_18920	COG0814	amino acid
K6748_18935	COG3314	Sporulation integral membrane protein YlbJ
K6748_18955	COG0739	heme binding
K6748_18960	COG5001	Diguanylate cyclase
K6748_18965	COG0583	DNA-binding transcription factor activity
K6748_18970	COG2814	Major facilitator Superfamily
K6748_18985	COG0697	spore germination
K6748_18990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6748_19000	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6748_19020	COG1280	lysine exporter protein (LysE YggA)
K6748_19030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6748_19035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6748_19040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6748_19045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K6748_19050	COG1845	cytochrome c oxidase, subunit III
K6748_19070	COG1612	heme a metabolic process
K6748_19075	COG0109	protoheme IX farnesyltransferase activity
K6748_19080	COG0545	Peptidyl-prolyl cis-trans isomerase
K6748_19110	COG1278	Cold shock
K6748_19115	COG3036	rescue of stalled ribosome
K6748_19120	COG2199	diguanylate cyclase activity
K6748_19135	COG1132	(ABC) transporter
K6748_19145	COG1538	Outer membrane efflux protein
K6748_19150	COG0784	Response regulator, receiver
K6748_19150	COG2205	protein histidine kinase activity
K6748_19175	COG0840	transmembrane signaling receptor activity
K6748_19180	COG0783	Belongs to the Dps family
K6748_19190	COG2133	pyrroloquinoline quinone binding
K6748_19195	COG1454	alcohol dehydrogenase
K6748_19200	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6748_19225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6748_19230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6748_19235	COG3186	Phenylalanine-4-hydroxylase
K6748_19260	COG3530	Putative quorum-sensing-regulated virulence factor
K6748_19275	COG2186	Transcriptional regulator
K6748_19290	COG1279	arginine transmembrane transporter activity
K6748_19310	COG0513	Belongs to the DEAD box helicase family
K6748_19315	COG4628	conserved protein (DUF2132)
K6748_19325	COG0133	tryptophan synthase activity
K6748_19330	COG1278	Cold shock
K6748_19340	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6748_19350	COG0523	cobalamin synthesis protein
K6748_19355	COG0513	Belongs to the DEAD box helicase family
K6748_19375	COG2200	EAL domain
K6748_19380	COG1119	ATPase activity
K6748_19415	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K6748_19420	COG0513	Belongs to the DEAD box helicase family
K6748_19430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6748_19440	COG1073	alpha beta
K6748_19445	COG1073	alpha beta
K6748_19460	COG0730	response to heat
K6748_19475	COG0735	belongs to the Fur family
K6748_19480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6748_19490	COG0523	cobalamin synthesis protein
K6748_19495	COG2988	succinylglutamate desuccinylase activity
K6748_19500	COG0739	heme binding
K6748_19505	COG0523	cobalamin synthesis protein
K6748_19520	COG2095	MarC family integral membrane protein
K6748_19545	COG1024	Enoyl-CoA hydratase
K6748_19550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6748_19555	COG1960	acyl-CoA dehydrogenase activity
K6748_19565	COG0183	Belongs to the thiolase family
K6748_19580	COG1024	Enoyl-CoA hydratase
K6748_19585	COG1024	Enoyl-CoA hydratase
K6748_19595	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_19600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6748_19605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6748_19610	COG1845	cytochrome c oxidase, subunit III
K6748_19615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6748_19620	COG0109	protoheme IX farnesyltransferase activity
K6748_19625	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6748_19625	COG1902	pentaerythritol trinitrate reductase activity
K6748_19640	COG1012	belongs to the aldehyde dehydrogenase family
K6748_19650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6748_19680	COG1126	abc transporter atp-binding protein
K6748_19685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6748_19690	COG4215	(ABC) transporter
K6748_19695	COG4160	amino acid transport
K6748_19765	COG0443	Heat shock 70 kDa protein
K6748_19770	COG2847	Copper chaperone PCu(A)C
K6748_19830	COG0814	amino acid
K6748_19840	COG0243	molybdopterin cofactor binding
K6748_19845	COG1648	precorrin-2 dehydrogenase activity
K6748_19845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6748_19865	COG1116	anion transmembrane transporter activity
K6748_19865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6748_19870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6748_19875	COG1116	anion transmembrane transporter activity
K6748_19880	COG2146	nitrite reductase [NAD(P)H] activity
K6748_19880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6748_19930	COG0515	serine threonine protein kinase
K6748_19930	COG2815	serine threonine protein kinase
K6748_19965	COG0631	protein serine/threonine phosphatase activity
K6748_20035	COG0420	3'-5' exonuclease activity
K6748_20040	COG0419	ATPase involved in DNA repair
K6748_20050	COG3040	lipid binding
K6748_20060	COG1288	antiporter activity
K6748_20070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K6748_20085	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6748_20100	COG0583	DNA-binding transcription factor activity
K6748_20105	COG0277	FAD linked oxidase domain protein
K6748_20120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6748_20305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6748_20325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6748_20330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6748_20340	COG2116	formate transmembrane transporter activity
K6748_20360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6748_20395	COG3118	belongs to the thioredoxin family
K6748_20400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6748_20425	COG2271	Major facilitator Superfamily
K6748_20430	COG3851	Histidine kinase
K6748_20435	COG2197	response regulator
K6748_20445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6748_20450	COG0583	DNA-binding transcription factor activity
K6748_20455	COG0243	molybdopterin cofactor binding
K6748_20470	COG0384	phenazine biosynthesis protein PhzF
K6748_20475	COG1794	racemase activity, acting on amino acids and derivatives
K6748_20505	COG1328	CTP reductase activity
K6748_20510	COG0602	queuosine metabolic process
K6748_20515	COG0534	Mate efflux family protein
K6748_20520	COG2207	Transcriptional regulator
K6748_20530	COG0189	ligase activity
K6748_20530	COG4067	protein conserved in archaea
K6748_20540	COG3111	PFAM Bacterial OB fold (BOF) protein
K6748_20550	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6748_20555	COG4149	molybdate abc transporter
K6748_20560	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6748_20570	COG5001	Diguanylate cyclase
K6748_20570	COG4251	negative regulation of phosphorylation
K6748_20570	COG2203	Gaf domain
K6748_20570	COG3706	GGDEF domain
K6748_20590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6748_20595	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6748_20620	COG3140	Belongs to the UPF0181 family
K6748_20670	COG4128	Pfam Zonular occludens toxin
K6748_20705	COG0023	Translation Initiation Factor
K6748_20715	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6748_20725	COG0045	succinate-CoA ligase (ADP-forming) activity
K6748_20725	COG1042	CoA-binding domain protein
K6748_20725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6748_20730	COG0583	DNA-binding transcription factor activity
K6748_20745	COG5001	Diguanylate cyclase
K6748_20745	COG5002	protein histidine kinase activity
K6748_20745	COG3447	MASE1 domain protein
K6748_20750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6748_20755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6748_20760	COG1984	allophanate hydrolase subunit 2
K6748_20770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6748_20775	COG4181	ATPase activity
K6748_20785	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6748_20790	COG3300	MHYT domain
K6748_20790	COG5001	Diguanylate cyclase
K6748_20825	COG4533	DNA binding
K6748_20835	COG2050	protein possibly involved in aromatic compounds catabolism
K6748_20850	COG2067	long-chain fatty acid transport protein
K6748_20855	COG2267	carboxylic ester hydrolase activity
K6748_20875	COG0861	Integral membrane protein TerC family
K6748_20880	COG0737	Belongs to the 5'-nucleotidase family
K6748_20885	COG3593	DNA synthesis involved in DNA repair
K6748_20895	COG0583	DNA-binding transcription factor activity
K6748_20900	COG2116	formate transmembrane transporter activity
K6748_20905	COG2353	YceI-like domain
K6748_20910	COG3038	cytochrome b561
K6748_20930	COG0513	Belongs to the DEAD box helicase family
K6748_20935	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K6748_20945	COG0840	transmembrane signaling receptor activity
K6748_20950	COG0546	phosphoglycolate phosphatase activity
K6748_20965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6748_20970	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6748_20975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6748_20985	COG2207	Transcriptional regulator
K6748_20990	COG1979	alcohol dehydrogenase
K6748_21000	COG1126	abc transporter atp-binding protein
K6748_21005	COG0765	amino acid transport
K6748_21010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6748_21015	COG0765	amino acid transport
K6748_21020	COG2200	EAL domain
K6748_21020	COG2203	Gaf domain
K6748_21020	COG2199	diguanylate cyclase activity
K6748_21035	COG1609	Transcriptional regulator
K6748_21040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6748_21040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6748_21045	COG1105	Belongs to the carbohydrate kinase PfkB family
K6748_21050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6748_21050	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K6748_21050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6748_21080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6748_21090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6748_21095	COG0509	glycine decarboxylation via glycine cleavage system
K6748_21105	COG0346	lactoylglutathione lyase activity
K6748_21110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6748_21115	COG0583	DNA-binding transcription factor activity
K6748_21120	COG0697	spore germination
K6748_21125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6748_21160	COG2176	DNA-directed DNA polymerase activity
K6748_21200	COG0242	peptide deformylase activity
K6748_21230	COG2239	Acts as a magnesium transporter
K6748_21250	COG0346	lactoylglutathione lyase activity
K6748_21255	COG1902	pentaerythritol trinitrate reductase activity
K6748_21275	COG5642	Protein of unknown function (DUF2384)
K6748_21280	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K6748_21315	COG2076	Multidrug Resistance protein
K6748_21335	COG2962	Rard protein
K6748_21350	COG0835	chemotaxis
K6748_21350	COG0784	Response regulator, receiver
K6748_21355	COG2197	response regulator
K6748_21365	COG3706	GGDEF domain
K6748_21370	COG2197	response regulator
K6748_21375	COG5001	Diguanylate cyclase
K6748_21375	COG3300	MHYT domain
K6748_21385	COG0582	viral genome integration into host DNA
K6748_21395	COG1134	teichoic acid transport
K6748_21440	COG2003	Belongs to the UPF0758 family
K6748_21480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6748_21500	COG1214	PFAM Peptidase M22, glycoprotease
K6748_21500	COG0456	acetyltransferase
K6748_21510	COG3069	C4-dicarboxylate transmembrane transporter activity
K6748_21535	COG3111	PFAM Bacterial OB fold (BOF) protein
K6748_21540	COG1597	lipid kinase activity
K6748_21545	COG0583	DNA-binding transcription factor activity
K6748_21550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6748_21580	COG0714	Associated with various cellular activities
K6748_21585	COG0641	radical SAM
K6748_21590	COG3119	arylsulfatase activity
K6748_21600	COG3119	arylsulfatase activity
K6748_21605	COG0745	RESPONSE REGULATOR receiver
K6748_21620	COG0784	Response regulator, receiver
K6748_21620	COG2198	Histidine kinase
K6748_21620	COG2205	protein histidine kinase activity
K6748_21625	COG1879	ABC-type sugar transport system periplasmic component
K6748_21630	COG1803	Methylglyoxal synthase
K6748_21635	COG0210	DNA helicase
K6748_21640	COG1289	transmembrane transporter activity
K6748_21670	COG1629	transport
K6748_21670	COG4771	TonB-dependent receptor
K6748_21680	COG0789	Transcriptional regulator
K6748_21685	COG4604	ABC transporter, ATP-binding protein
K6748_21690	COG4605	iron ion homeostasis
K6748_21695	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6748_21700	COG4607	ABC-type enterochelin transport system periplasmic component
K6748_21710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6748_21720	COG1609	Transcriptional regulator
K6748_21725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6748_21730	COG1879	ABC-type sugar transport system periplasmic component
K6748_21735	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6748_21740	COG1129	ABC transporter
K6748_21745	COG1869	D-ribose catabolic process
K6748_21750	COG5001	Diguanylate cyclase
K6748_21805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6748_21815	COG0784	Response regulator, receiver
K6748_21815	COG2205	protein histidine kinase activity
K6748_21830	COG0330	HflC and HflK could
K6748_21845	COG0517	IMP dehydrogenase activity
K6748_21845	COG4175	Glycine betaine
K6748_21850	COG4176	ABC-type proline glycine betaine transport system permease component
K6748_21865	COG1012	belongs to the aldehyde dehydrogenase family
K6748_21870	COG1309	transcriptional regulator
K6748_21880	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_21895	COG1024	Enoyl-CoA hydratase
K6748_21900	COG1960	acyl-CoA dehydrogenase activity
K6748_21910	COG0183	Belongs to the thiolase family
K6748_21920	COG1960	acyl-CoA dehydrogenase activity
K6748_21925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6748_21935	COG4770	biotin carboxylase activity
K6748_21950	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6748_21950	COG3264	Mechanosensitive ion channel
K6748_21955	COG0110	maltose O-acetyltransferase activity
K6748_21960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6748_21965	COG1271	oxidase subunit
K6748_21970	COG1294	oxidase, subunit
K6748_21985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6748_21995	COG3527	Alpha-acetolactate decarboxylase
K6748_22010	COG0500	methyltransferase
K6748_22040	COG1022	Amp-dependent synthetase and ligase
K6748_22065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6748_22070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6748_22070	COG1263	PTS System
K6748_22075	COG1486	melibiose metabolic process
K6748_22080	COG2188	Transcriptional regulator
K6748_22085	COG1320	monovalent cation:proton antiporter activity
K6748_22090	COG2212	antiporter activity
K6748_22095	COG1863	multisubunit Na H antiporter MnhE subunit
K6748_22100	COG0651	ATP synthesis coupled electron transport
K6748_22105	COG1006	Multisubunit Na H antiporter MnhC subunit
K6748_22110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6748_22110	COG2111	Na H antiporter
K6748_22120	COG0589	response to stress
K6748_22125	COG4221	oxidoreductase activity
K6748_22130	COG0583	DNA-binding transcription factor activity
K6748_22140	COG2814	Major facilitator Superfamily
K6748_22195	COG1522	sequence-specific DNA binding
K6748_22230	COG0515	serine threonine protein kinase
K6748_22255	COG3501	Rhs element vgr protein
K6748_22295	COG0739	heme binding
K6748_22310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6748_22355	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K6748_22365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6748_22365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6748_22380	COG4989	oxidoreductase activity
K6748_22395	COG0038	chloride channel
K6748_22430	COG2897	thiosulfate sulfurtransferase activity
K6748_22440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6748_22445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6748_22455	COG2814	Major facilitator Superfamily
K6748_22460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6748_22470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6748_22480	COG0840	transmembrane signaling receptor activity
K6748_22500	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6748_22515	COG2197	response regulator
K6748_22520	COG3850	Histidine kinase
K6748_22525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6748_22535	COG0243	molybdopterin cofactor binding
K6748_22545	COG3005	denitrification pathway
K6748_22555	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6748_22565	COG0183	Belongs to the thiolase family
K6748_22575	COG1280	lysine exporter protein (LysE YggA)
K6748_22585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6748_22590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6748_22640	COG1846	Transcriptional regulator
K6748_22645	COG2205	protein histidine kinase activity
K6748_22645	COG0784	Response regulator, receiver
K6748_22650	COG1879	ABC-type sugar transport system periplasmic component
K6748_22655	COG2827	Endonuclease containing a URI domain
K6748_22660	COG3132	Protein of unknown function, DUF480
K6748_22680	COG0784	Response regulator, receiver
K6748_22680	COG2205	protein histidine kinase activity
K6748_22680	COG5002	protein histidine kinase activity
K6748_22705	COG0583	DNA-binding transcription factor activity
K6748_22715	COG0531	amino acid
K6748_22730	COG2205	protein histidine kinase activity
K6748_22735	COG0745	RESPONSE REGULATOR receiver
K6748_22760	COG1566	PFAM secretion protein HlyD family protein
K6748_22765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6748_22770	COG2239	Acts as a magnesium transporter
K6748_22775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6748_22780	COG0402	S-adenosylhomocysteine deaminase activity
K6748_22785	COG1418	mRNA catabolic process
K6748_22795	COG2814	Major facilitator Superfamily
K6748_22805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6748_22825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6748_22840	COG0745	RESPONSE REGULATOR receiver
K6748_22845	COG2205	protein histidine kinase activity
K6748_22855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6748_22860	COG2194	sulfuric ester hydrolase activity
K6748_22880	COG4667	esterase of the alpha-beta hydrolase superfamily
K6748_22885	COG1741	Belongs to the pirin family
K6748_22890	COG1278	Cold shock
K6748_22905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6748_22910	COG0678	peroxiredoxin activity
K6748_22910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6748_22920	COG1686	Belongs to the peptidase S11 family
K6748_22925	COG0625	glutathione transferase activity
K6748_22930	COG1621	beta-fructofuranosidase activity
K6748_22935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6748_22940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6748_22940	COG1263	PTS System
K6748_22960	COG4771	TonB-dependent receptor
K6748_22965	COG0583	DNA-binding transcription factor activity
K6748_22975	COG1404	Belongs to the peptidase S8 family
K6748_22980	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_22995	COG3746	phosphate-selective porin O and P
K6748_23010	COG0300	oxidoreductase activity
K6748_23015	COG0583	DNA-binding transcription factor activity
K6748_23020	COG2207	Transcriptional regulator
K6748_23020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6748_23025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6748_23045	COG0513	Belongs to the DEAD box helicase family
K6748_23055	COG0583	DNA-binding transcription factor activity
K6748_23070	COG1902	pentaerythritol trinitrate reductase activity
K6748_23075	COG1063	alcohol dehydrogenase
K6748_23085	COG1028	Short-chain dehydrogenase reductase Sdr
K6748_23095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6748_23100	COG0006	proline dipeptidase activity
K6748_23105	COG3608	succinylglutamate desuccinylase aspartoacylase
K6748_23110	COG1522	sequence-specific DNA binding
K6748_23115	COG1012	belongs to the aldehyde dehydrogenase family
K6748_23120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6748_23125	COG3122	Protein conserved in bacteria
K6748_23140	COG0583	DNA-binding transcription factor activity
K6748_23145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6748_23150	COG0252	asparaginase activity
K6748_23155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6748_23170	COG2197	response regulator
K6748_23175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6748_23200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6748_23230	COG3842	ATPase activity
K6748_23260	COG4680	protein conserved in bacteria
K6748_23265	COG5499	transcription regulator containing HTH domain
K6748_23375	COG4974	Belongs to the 'phage' integrase family
K6748_23465	COG0776	regulation of translation
K6748_23495	COG0629	single-stranded DNA binding
K6748_23580	COG1462	curli production assembly transport component CsgG
K6748_23700	COG0202	RNA polymerase activity